Application of combination of 3-indoleacetic acid and temozolomide in resisting brain glioma

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By combining 3-indoleacetic acid with temozolomide, the problem of poor efficacy and drug resistance in treating brain gliomas was solved, and significant anti-brain glioma effects and reduced toxic and side effects were achieved, providing a new method for the treatment of brain gliomas.

CN119970724APending Publication Date: 2025-05-13JIANGHAN UNIVERSITY

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Patent Information

Application Number: CN202510332228.9
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2025-03-20
Publication Date: 2025-05-13

Application Information

Patent Timeline

20 Mar 2025

Application

CN202510332228.9

13 May 2025

Publication

CN119970724A

IPC: A61K31/4188; A61K31/405; A61P35/00; A61P25/00

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Application Domain

Organic active ingredients Nervous disorder

Technology Topics

Indole acetic acid Pharmaceutical drug

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AI Technical Summary

Technical Problem

In the prior art, temozolomide is used to treat brain gliomas with poor efficacy and serious drug resistance, and lacks effective means to overcome drug resistance and improve efficacy.

Method used

Using 3-indoleacetic acid with temozolomide, experiments show that it can synergistically resist brain glioma, significantly inhibit the proliferation and apoptosis induction of brain glioma cells, and reduce the toxic side effects of temozolomide.

Benefits of technology

The combined use of 3-indoleacetic acid and temozolomide significantly improved the inhibitory effect on brain glioma cells and reduced the toxic side effects in temozolomide treatment, providing new ideas for the treatment of brain glioma.

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Abstract

The invention provides application of 3-indoleacetic acid combined with temozolomide in resisting brain glioma, and belongs to the field of biological medicine. Wherein the 3-indoleacetic acid can significantly enhance the inhibition effect of temozolomide on brain glioma cells in a short period and a long period, and can significantly enhance the apoptosis induction effect of temozolomide on the brain glioma cells, and after the 3-indoleacetic acid and temozolomide are applied to a brain glioma animal model, the 3-indoleacetic acid and temozolomide are combined, so that the inhibition effect of temozolomide on brain glioma cells is obviously improved. The 3-indoleacetic acid and temozolomide can obviously inhibit the development of brain glioma and relieve weight loss caused by temozolomide administration, so that the 3-indoleacetic acid and temozolomide have the potential of being developed into the anti-brain glioma medicine.

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