Ceftazidime for injection and preparation method thereof

Abstract

The invention belongs to the technical field of medicines, and particularly relates to ceftazidime for injection and a preparation method thereof. The method comprises the following steps: sequentially carrying out ultrasonic treatment on a ceftazidime crude product, dissolving the ceftazidime crude product in water, adjusting the pH value of a mixed solution to 1.8-2.0 at 3-4 DEG C, carrying out ultrasonic decoloration by using a compound decolorizing agent, adjusting the pH value to 6.5-6.8, carrying out solid substance precipitation by using a tert-butyl alcohol solution, adjusting the pH value to 3.8-4.2, crystallizing, filtering and the like. The purity of the ceftazidime is greatly improved, the prepared ceftazidime for injection has the advantages of being high in purity, few in impurity and high in stability, and the scheme is simple, easy to implement and high in efficiency.

Description

Technical Field

[0001] The present invention belongs to the technical field of medicine, and particularly relates to ceftazidime for injection and a preparation method thereof. Background Art

[0002] Ceftazidime is a semi-synthetic third-generation cephalosporin antibiotic, also known as cefotaxime, ceftazidime, cefotaxime, cefotaxime, cefotaxime, etc. It mainly exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls, resulting in the death of bacteria, and has a wide range of clinical applications.

[0003] However, during the preparation of ceftazidime, it is easily affected by pH value and temperature. During storage, not only chemical reactions will occur, but also impurities such as ceftazidime polymers will be generated, which is not conducive to clinical use. Although some methods for purifying ceftazidime have been disclosed at home and abroad, these methods still have the characteristics of low purity after purification, complex operation and low efficiency. Summary of the Invention

[0004] The purpose of the present invention is to provide ceftazidime for injection and a preparation method thereof, which have the advantages of simple operation and high efficiency.

[0005] The present invention provides a preparation method of ceftazidime for injection, comprising the following steps:

[0006] Performing a first ultrasonic treatment on the crude ceftazidime to obtain the treated crude product;

[0007] Mixing the treated crude product with water at 3-4 °C to obtain a mixed solution;

[0008] Adjusting the pH of the mixed solution to 1.8-2.0 to obtain an acidic solution;

[0009] Adding a decolorizing agent to the acidic solution, and sequentially performing a second ultrasonic treatment and filtration to obtain filtrate 1;

[0010] Adjusting the pH of filtrate 1 to 6.5-6.8 and then standing to obtain filtrate 2;

[0011] Mixing filtrate 2 with a tert-butanol solution at 3-4 °C to obtain filtrate 3;

[0012] Adjusting the pH of filtrate 3 to 3.8-4.2, and then performing crystallization and filtration to obtain ceftazidime for injection.

[0013] Preferably, the parameters of the first ultrasonic treatment are: temperature is 12-14 °C, time is 10-15 min, and power is 100-120 w;

[0014] The parameters of the second ultrasonic treatment are as follows: the temperature is 12 - 14°C, the time is 25 - 35 min, and the power is 50 - 60 w.

[0015] Preferably, the decolorizing agent includes coconut shell activated carbon and alumina;

[0016] The mass ratio of the coconut shell activated carbon to the alumina is 1:1 - 1.25.

[0017] Preferably, the volume - mass ratio of the acidic solution to the decolorizing agent is 100 mL:1.5 - 1.6 g.

[0018] Preferably, the concentration of the mixed solution is 350 - 450 mg / mL.

[0019] Preferably, the pH of the mixed solution is adjusted to 1.8 - 2.0 with concentrated sulfuric acid.

[0020] Preferably, the pH of the filtrate 1 is adjusted to 6.5 - 6.8 with sodium hydroxide solution and then left to stand; the parameters of the standing include: the time is 3 - 5 min, and the temperature is 12 - 14°C.

[0021] Preferably, when adding tert - butanol solution dropwise to the filtrate 2 for mixing, the addition of tert - butanol solution is stopped when solid substances precipitate in the filtrate 2;

[0022] Stirring is accompanied during the mixing; the speed of the stirring is 50 - 70 rpm, and the time is 8 - 10 h.

[0023] Preferably, the pH of the filtrate 3 is adjusted to 3.8 - 4.2 with hydrochloric acid.

[0024] Preferably, the parameters during the crystallization treatment include: the time is 10 - 18 h, and the temperature is 12 - 15°C.

[0025] Beneficial effects:

[0026] The present invention provides a preparation method of ceftazidime for injection, which comprises the following steps: performing a first ultrasonic treatment on the crude ceftazidime to obtain the treated crude product; mixing the treated crude product with water at 3 - 4 °C to obtain a mixed solution; adjusting the pH of the mixed solution to 1.8 - 2.0 to obtain an acidic solution; adding a decolorizing agent to the acidic solution, and successively performing a second ultrasonic treatment and filtration to obtain filtrate 1; adjusting the pH of filtrate 1 to 6.5 - 6.8 and then standing to obtain filtrate 2; mixing filtrate 2 with a tert-butanol solution at 3 - 4 °C to obtain filtrate 3; adjusting the pH of filtrate 3 to 3.8 - 4.2, and then performing crystallization and filtration to obtain ceftazidime for injection. By performing multiple ultrasonic treatments on the crude ceftazidime and using tert-butanol to precipitate solid substances, the present invention greatly improves the purity of ceftazidime, has strong stability, is convenient for long-term storage and use. At the same time, the solution of the present invention is simple and easy to implement, and has high efficiency. Detailed implementation mode

[0027] In the present invention, unless otherwise specified, the raw materials, methods and equipment used are all conventional selections.

[0028] In order to further illustrate the present invention, the following describes in detail the solution provided by the present invention in combination with embodiments, but they cannot be understood as limiting the protection scope of the present invention.

[0029] Example 1

[0030] A preparation method of ceftazidime for injection, the steps are as follows:

[0031] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0032] At 3 °C, mix the treated crude product with 100 mL of water evenly to obtain a mixed solution with a concentration of 380 mg / mL;

[0033] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.82 to obtain an acidic solution;

[0034] Add 1.6 g of decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 28 min, power is 50 w). After ultrasonic treatment, perform filtration to obtain filtrate 1;

[0035] Adjust the pH of filtrate 1 to 6.56 with sodium hydroxide solution, and then stand at 12 °C for 5 min to obtain filtrate 2;

[0036] At 3°C, a tert-butanol solution was added dropwise with stirring to filtrate 2, and the addition of the tert-butanol solution was stopped when a fixed substance precipitated from filtrate 2. The stirring speed was 50 rpm and the stirring time was 8 h to obtain filtrate 3;

[0037] After adjusting the pH of filtrate 3 to 3.85 with hydrochloric acid, crystallization was carried out at 15°C for 10 h. The precipitated crystals were collected, washed, and vacuum dried to obtain ceftazidime for injection.

[0038] Example 2

[0039] A preparation method of ceftazidime for injection, the steps are as follows:

[0040] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12°C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0041] At 3°C, the treated crude product was mixed evenly with 100 mL of water to obtain a mixed solution with a concentration of 420 mg / mL;

[0042] Concentrated sulfuric acid was added to adjust the pH of the mixed solution to 1.80 to obtain an acidic solution;

[0043] 1.6 g of a decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1.25) was added to the acidic solution, and then ultrasonic treatment was carried out (ultrasonic treatment parameters: temperature is 12°C, time is 28 min, power is 50 w). After ultrasonic treatment, filtration was carried out to obtain filtrate 1;

[0044] The pH of filtrate 1 was adjusted to 6.51 with sodium hydroxide solution, and it was left standing at 12°C for 5 min to obtain filtrate 2;

[0045] At 3°C, a tert-butanol solution was added dropwise with stirring to filtrate 2, and the addition of the tert-butanol solution was stopped when a fixed substance precipitated from filtrate 2. The stirring speed was 50 rpm and the stirring time was 8 h to obtain filtrate 3;

[0046] After adjusting the pH of filtrate 3 to 3.82 with hydrochloric acid, crystallization was carried out at 15°C for 10 h. The precipitated crystals were collected, washed, and vacuum dried to obtain ceftazidime for injection.

[0047] Comparative Example 1

[0048] A preparation method of ceftazidime for injection, the steps are as follows:

[0049] Weigh 50 g of the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 20°C, time is 10 min, power is 200 w) to obtain the treated crude product;

[0050] At 3°C, after uniformly mixing the treated crude product with 100 mL of water, a mixed solution with a concentration of 380 mg / mL was obtained;

[0051] Concentrated sulfuric acid was added to adjust the pH of the mixed solution to 1.83 to obtain an acidic solution;

[0052] 1.6 g of a decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1) was added to the acidic solution, and then ultrasonic treatment was carried out (ultrasonic treatment parameters: temperature 12°C, time 28 min, power 50 w). After ultrasonic treatment, filtration was carried out to obtain filtrate 1;

[0053] After adjusting the pH of filtrate 1 to 6.55 with sodium hydroxide solution, it was left standing at 12°C for 5 min to obtain filtrate 2;

[0054] At 3°C, a tert-butanol solution was added dropwise with stirring to filtrate 2, and the addition of the tert-butanol solution was stopped when a solid substance precipitated from filtrate 2. The stirring speed was 50 rpm and the stirring time was 8 h to obtain filtrate 3;

[0055] After adjusting the pH of filtrate 3 to 3.84 with hydrochloric acid, crystallization was carried out at 15°C for 10 h. The crystallized product was collected, washed, and vacuum dried to obtain ceftazidime for injection.

[0056] Comparative Example 2

[0057] A preparation method of ceftazidime for injection, the steps are as follows:

[0058] At 3°C, a ceftazidime crude product was weighed and uniformly mixed with 100 mL of water to obtain a mixed solution with a concentration of 380 mg / mL;

[0059] Concentrated sulfuric acid was added to adjust the pH of the mixed solution to 1.90 to obtain an acidic solution;

[0060] 1.6 g of a decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1) was added to the acidic solution, and then ultrasonic treatment was carried out (ultrasonic treatment parameters: temperature 12°C, time 28 min, power 50 w). After ultrasonic treatment, filtration was carried out to obtain filtrate 1;

[0061] After adjusting the pH of filtrate 1 to 6.61 with sodium hydroxide solution, it was left standing at 12°C for 5 min to obtain filtrate 2;

[0062] At 3°C, a tert-butanol solution was added dropwise with stirring to filtrate 2, and the addition of the tert-butanol solution was stopped when a solid substance precipitated from filtrate 2. The stirring speed was 50 rpm and the stirring time was 8 h to obtain filtrate 3;

[0063] After adjusting the pH of filtrate 3 to 3.92 with hydrochloric acid, crystallization is carried out at 15 °C for 10 h. The crystallized product is collected, washed and dried under vacuum to obtain ceftazidime for injection.

[0064] Comparative Example 3

[0065] A preparation method of ceftazidime for injection, the steps are as follows:

[0066] Weigh the crude ceftazidime and carry out ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0067] At 3 °C, after mixing the treated crude product with 100 mL of water evenly, a mixed solution with a concentration of 350 mg / mL is obtained;

[0068] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.92 to obtain an acidic solution;

[0069] Add 1.6 g of decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 3:1) to the acidic solution for decolorization and filtration to obtain filtrate 1;

[0070] Adjust the pH of filtrate 1 to 6.56 with sodium hydroxide solution and let it stand at 12 °C for 5 min to obtain filtrate 2;

[0071] At 3 °C, dropwise add tert-butanol solution to filtrate 2 with stirring and stop adding the tert-butanol solution when a fixed substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0072] After adjusting the pH of filtrate 3 to 4.01 with hydrochloric acid, crystallization is carried out at 15 °C for 10 h. The crystallized product is collected, washed and dried under vacuum to obtain ceftazidime for injection.

[0073] Comparative Example 4

[0074] A preparation method of ceftazidime for injection, the steps are as follows:

[0075] Weigh the crude ceftazidime and carry out ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0076] At 3 °C, after mixing the treated crude product with 100 mL of water evenly, a mixed solution with a concentration of 380 mg / mL is obtained;

[0077] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.95 to obtain an acidic solution;

[0078] Add 1.6 g of decolorizer (the decolorizer is activated carbon) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 30 min, power is 80 w). After ultrasonic treatment, filter to obtain filtrate 1;

[0079] Adjust the pH of filtrate 1 to 6.52 with sodium hydroxide solution, and then let it stand at 12 °C for 5 min to obtain filtrate 2;

[0080] At 3 °C, stir and dropwise add tert-butanol solution to filtrate 2, and stop adding tert-butanol solution when a fixed substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0081] Adjust the pH of filtrate 3 to 3.97 with hydrochloric acid, and then crystallize at 15 °C for 10 h. Collect the crystallized product, wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0082] Comparative Example 5

[0083] A preparation method of ceftazidime for injection, the steps are as follows:

[0084] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0085] At 3 °C, mix the treated crude product with 100 mL of water evenly to obtain a mixed solution with a concentration of 380 mg / mL;

[0086] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.80 to obtain an acidic solution;

[0087] Add 2 g of decolorizer (the decolorizer is alumina) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 28 min, power is 50 w). After ultrasonic treatment, filter to obtain filtrate 1;

[0088] Adjust the pH of filtrate 1 to 6.64 with sodium hydroxide solution, and then let it stand at 12 °C for 5 min to obtain filtrate 2;

[0089] At 3 °C, stir and dropwise add tert-butanol solution to filtrate 2, and stop adding tert-butanol solution when a fixed substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0090] Adjust the pH of filtrate 3 to 3.92 with hydrochloric acid, and then crystallize at 15 °C for 10 h. Collect the crystallized product, wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0091] Comparative Example 6

[0092] A preparation method of ceftazidime for injection, the steps are as follows:

[0093] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0094] At 3 °C, mix the treated crude product evenly with 100 mL of water to obtain a mixed solution with a concentration of 380 mg / mL;

[0095] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.54 to obtain an acidic solution;

[0096] Add 1.6 g of decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 28 min, power is 50 w). After ultrasonic treatment, filter to obtain filtrate 1;

[0097] Adjust the pH of filtrate 1 to 6.21 with sodium hydroxide solution, and then let it stand at 12 °C for 5 min to obtain filtrate 2;

[0098] At 3 °C, stir and dropwise add tert-butanol solution to filtrate 2, and stop adding tert-butanol solution when a fixed substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0099] Adjust the pH of filtrate 3 to 4.51 with hydrochloric acid, then crystallize at 15 °C for 10 h, collect the crystallized product, and wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0100] Comparative Example 7

[0101] A preparation method of ceftazidime for injection, the steps are as follows:

[0102] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0103] At 5 °C, mix the treated crude product evenly with 100 mL of water to obtain a mixed solution with a concentration of 380 mg / mL;

[0104] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.81 to obtain an acidic solution;

[0105] Add 1.6 g of decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:1) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 28 min, power is 50 w). After ultrasonic treatment, filter to obtain filtrate 1;

[0106] Adjust the pH of filtrate 1 to 6.74 with sodium hydroxide solution, and then let it stand at 8 °C for 5 min to obtain filtrate 2;

[0107] At 5 °C, stir and dropwise add tert-butanol solution to filtrate 2, and stop adding tert-butanol solution when a solid substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0108] Adjust the pH of filtrate 3 to 3.82 with hydrochloric acid, and then crystallize at 10 °C for 10 h. Collect the crystallized product, wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0109] Comparative Example 8

[0110] A preparation method of ceftazidime for injection, the steps are as follows:

[0111] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 20 °C, time is 10 min, power is 50 w) to obtain the treated crude product;

[0112] At 3 °C, mix the treated crude product with 100 mL of water evenly to obtain a mixed solution with a concentration of 380 mg / mL;

[0113] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.95 to obtain an acidic solution;

[0114] Add 1.6 g of decolorizing agent (the decolorizing agent is composed of coconut shell activated carbon and alumina in a mass ratio of 1:3) to the acidic solution, and then perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12 °C, time is 28 min, power is 50 w). After ultrasonic treatment, filter to obtain filtrate 1;

[0115] Adjust the pH of filtrate 1 to 6.32 with sodium hydroxide solution, and then let it stand at 12 °C for 5 min to obtain filtrate 2;

[0116] At 3 °C, stir and dropwise add tert-butanol solution to filtrate 2, and stop adding tert-butanol solution when a solid substance precipitates in filtrate 2. The stirring speed is 50 rpm and the stirring time is 8 h to obtain filtrate 3;

[0117] Adjust the pH of filtrate 3 to 3.85 with hydrochloric acid, and then crystallize at 15 °C for 10 h. Collect the crystallized product, wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0118] Comparative Example 9

[0119] A preparation method of ceftazidime for injection, the steps are as follows:

[0120] Weigh the crude ceftazidime and perform ultrasonic treatment (ultrasonic treatment parameters: temperature is 12°C, time is 10 min, power is 100 w) to obtain the treated crude product;

[0121] At 3°C, mix the treated crude product with 100 mL of water evenly to obtain a mixed solution with a concentration of 380 mg / mL;

[0122] Add concentrated sulfuric acid to adjust the pH of the mixed solution to 1.91 to obtain an acidic solution;

[0123] Add 1.6 g of decolorizing agent to the acidic solution for decolorization and filtration to obtain filtrate 1;

[0124] Adjust the pH of filtrate 1 to 6.71 with sodium hydroxide solution, and then let it stand at 12°C for 5 min to obtain filtrate 2;

[0125] At 3°C, stir and dropwise add methanol solution to filtrate 2, stop adding methanol solution when a fixed substance precipitates in filtrate 2, the stirring speed is 50 rpm, and the stirring time is 8 h to obtain filtrate 3;

[0126] Adjust the pH of filtrate 3 to 3.83 with concentrated sulfuric acid, then crystallize at 15°C for 10 h, collect the crystallized product, and wash and vacuum dry the crystallized product to obtain ceftazidime for injection.

[0127] Application Example 1

[0128] According to the standards of the 2015 edition of the Chinese Pharmacopoeia, the injection ceftazidime prepared in Examples 1-2 and Comparative Examples 1-9 was tested for indicators such as loss on drying, content, acidity, polymers, etc., and the results are shown in Table 1.

[0129] Table 1 Detection results in different treatments

[0130]

[0131] Combined with the data in Table 1, it can be seen that compared with Comparative Examples 2-9, the injection ceftazidime obtained by the preparation methods in Examples 1-2 has stable quality and the corresponding indicators more meet the relevant standards of the Chinese Pharmacopoeia; in addition, although the injection ceftazidime prepared in Comparative Example 1 also meets the relevant standards of the Chinese Pharmacopoeia, its content is only 96.5%, which is lower than that in Examples 1 and 2. Thus, it can be seen that the preparation method of the technical solution provided by the present invention is simpler and has good reproducibility.

[0132] Application Example 2

[0133] According to the detection results in Application Example 1, the ceftazidime for injection prepared in Examples 1 and 2 and Comparative Example 1 was stored to determine the stability of each product, and the corresponding indexes of ceftazidime for injection in each treatment were respectively counted at 15d, 30d, 45d and 60d of storage. The results are shown in Table 2.

[0134] Table 2 Detection Results in Different Treatments

[0135]

[0136] Combined with the data in Table 2, it can be seen that compared with Comparative Example 1, the ceftazidime for injection prepared by the technical solutions in Examples 1 and 2 still maintained a content of more than 98.9% after 60d of storage, was more stable and had better quality.

[0137] In summary, in the present invention, the crude ceftazidime is successively subjected to ultrasonic treatment, dissolved in water, the pH of the mixed solution is adjusted to 1.8 - 2.0 at 3 - 4°C, ultrasonic decolorization is carried out using a compound decolorizing agent, then the pH is adjusted to 6.5 - 6.8, solid substances are precipitated using a tert-butanol solution, the pH is adjusted to 3.8 - 4.2 and then crystallization and filtration are carried out. These operation steps greatly improve the purity of ceftazidime. The ceftazidime for injection prepared thereby has the characteristics of high purity, few impurities and strong stability, and the solution of the present invention is simple, feasible and efficient.

[0138] Although the above embodiments have described the present invention in detail, they are only a part of the embodiments of the present invention, not all embodiments. People can also obtain other embodiments based on these embodiments without creative efforts, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A method for preparing ceftazidime for injection, characterized in that: The steps include: The crude ceftazidime product is subjected to a first ultrasonic treatment to obtain a treated crude product; Mixing the treated crude product with water at 3-4° C. to obtain a mixed solution; The pH of the mixed solution is adjusted to 1.8-2.0 to obtain an acidic solution; Adding a decolorizing agent to the acidic solution, and performing a second ultrasonic treatment and filtering in sequence to obtain a filtrate 1; The pH of the filtrate 1 is adjusted to 6.5-6.8 and then allowed to stand to obtain a filtrate 2; At 3-4° C., mixing the filtrate 2 with a tert-butyl alcohol solution to obtain a filtrate 3; After adjusting the pH of the filtrate 3 to 3.8-4.2, ceftazidime for injection is obtained through crystallization and filtration.

2. The preparation method according to claim 1, characterized in that: The parameters of the first ultrasonic treatment are: temperature 12-14°C, time 10-15min, power 100-120w; The parameters of the second ultrasonic treatment are: temperature of 12-14°C, time of 25-35min, power of 50-60w.

3. The preparation method according to claim 1, characterized in that: The decolorizing agent includes coconut shell activated carbon and aluminum oxide; The mass ratio of the coconut shell activated carbon to alumina is 1:1-1.

25.

4. The preparation method according to claim 1 or 3, characterized in that: The volume mass ratio of the acidic solution to the decolorizing agent is 100 mL: 1.5-1.6 g.

5. The preparation method according to claim 1, characterized in that: The concentration of the mixed solution is 350-450 mg / mL.

6. The preparation method according to claim 1 or 5, characterized in that: The pH of the mixed solution was adjusted to 1.8-2.0 with concentrated sulfuric acid.

7. The preparation method according to claim 1, characterized in that: The pH of the filtrate 1 is adjusted to 6.5-6.8 with sodium hydroxide solution and then allowed to stand; the parameters of the standing state include: time of 3-5 minutes and temperature of 12-14°C.

8. The preparation method according to claim 1, characterized in that: When the tert-butanol solution is added dropwise to the filtrate 2 for mixing, the addition of the tert-butanol solution is stopped when a fixed substance is precipitated in the filtrate 2; The mixing is accompanied by stirring; the stirring speed is 50-70 rpm and the time is 8-10 hours.

9. The preparation method according to claim 1, characterized in that: The pH of the filtrate 3 is adjusted to 3.8-4.2 with hydrochloric acid.

10. The preparation method according to claim 1, characterized in that: The parameters for the crystallization treatment include: time of 10-18 hours and temperature of 12-15°C.

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