Bromfenac prodrug preparation as well as preparation method and application thereof
By forming bromfenac glycerol ester through ester bonds, bromfenac prodrug preparations were prepared and applied in the form of emulsions, the problem of eye sting caused by bromfenac sodium drops was solved, and the effect of reducing sting and exerting anti-inflammatory effects was achieved.
CN120093935AInactive Publication Date: 2025-06-06JIANGSU YUANHENG PHARMA +1
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Patent Information
- Application Number
- CN202510283834.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-11
- Publication Date
- 2025-06-06
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
Bromfenac sodium eye drops may cause tingling, redness or itching of the eyes during use, reducing the patient's medication compliance.
Method used
A bromfenac prodrug preparation is prepared by forming bromfenac glycerol ester through an ester bond with glycerol, and prepared in emulsion form to reduce the extent of eye sting.
Benefits of technology
Bromfenac prodrug preparations significantly reduce the degree of sting in the eyes. At the same time, hydrolyzed at the inflammatory site by phospholipase, releasing the bromfenac sodium prototype, exerting a strong anti-inflammatory effect and effectively reducing the occurrence of local adverse reactions.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a bromfenac prodrug preparation as well as a preparation method and application thereof. The preparation method comprises the step of forming bromfenac glycerol ester from bromfenac sodium and glycerol through an ester bond. Compared with bromfenac sodium eye drops, the bromfenac prodrug preparation obviously reduces the degree of eye stabbing. Meanwhile, in an inflammation part, the bromfenac prodrug preparation is hydrolyzed under the action of phospholipase, a bromfenac sodium prototype is released, and a powerful anti-inflammatory effect is exerted, so that the bromfenac sodium eye drops effectively solve the symptoms of eye stabbing pain, redness and the like in the use process, and effectively reduce local adverse reactions.
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