Tibetan medicine composition as well as preparation method and application thereof

Abstract

The invention relates to a Tibetan medicine composition which is characterized by comprising the following raw material medicines in parts by weight: 180-220 parts of lamiophlomis rotata, 100-140 parts of pseudo-ginseng, 80-120 parts of dragon's blood, 8-12 parts of artificial musk, 80-120 parts of catechu and 100-140 parts of carthamus tinctorius. The invention also provides application of the composition in treatment of soft tissue injury.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly to a Tibetan medicine composition and its applications. Background Art

[0002] Soft tissue injury refers to the mechanical injury of non-bony tissues such as human skin, muscles, tendons, ligaments, fascia, synovium, blood vessels, nerves, etc. It is usually caused by external forces or overuse, and can lead to symptoms such as local pain, swelling, and functional impairment. Common types of injuries include: Acute injuries: such as contusions, strains, sprains, lacerations (such as muscle strains, ankle sprains); Chronic injuries: such as tendinitis, bursitis, overuse injuries (caused by long-term repetitive movements).

[0003] The main causes of soft tissue injury are as follows:

[0004] 1. Traumatic factors, such as, direct violence: impact, compression (such as contusions caused by falls, car accidents); indirect violence: excessive stretching or torsion (such as muscle strains and joint sprains during exercise); sharp instrument injuries: cuts, stabs (such as knife wounds, glass cuts).

[0005] 2. Overuse or chronic strain, such as, repetitive movements: long-term typing causing carpal tunnel syndrome, medial tibial stress syndrome in runners; poor posture: lumbar muscle strain and neck and shoulder fascia pain caused by long-term sitting.

[0006] 3. Biomechanical abnormalities, such as joint instability: ligament laxity leading to repeated sprains (such as habitual ankle sprains); muscle imbalance: weakness of the core muscles causing compensatory back injuries.

[0007] 4. Environmental and external force factors, for example, low temperature: cold environments are likely to induce muscle stiffness and strains; insufficient warm-up: failure to fully stretch before exercise, increasing the risk of muscle tears, etc.

[0008] Soft tissue injury may directly trigger or coexist with the following diseases:

[0009] 1. Inflammatory diseases, such as, tendinitis / tenosynovitis: such as tennis elbow (lateral epicondylitis), mommy's thumb (stenosing tenosynovitis of the radial styloid process); bursitis: subacromial bursitis, prepatellar bursitis.

[0010] 2. Degenerative diseases, such as, osteoarthritis: chronic soft tissue injury leads to a decrease in joint stability, accelerating cartilage wear; intervertebral disc herniation: lumbar muscle strain increases the pressure on the intervertebral disc, inducing herniation.

[0011] 3. Nerve entrapment syndromes, such as, carpal tunnel syndrome: wrist tendinitis compresses the median nerve; piriformis syndrome: hip muscle injury stimulates the sciatic nerve.

[0012] 4. Chronic pain syndromes, such as myofascial pain syndrome: trigger point formation leads to widespread pain; fibromyalgia: may be related to central sensitization after long-term soft tissue injury.

[0013] 5. Other related diseases, such as hematoma or infection: local hematoma organization after severe contusion, or secondary infection after open injury; traumatic arthritis: repeated soft tissue injury around the joint leads to joint degeneration.

[0014] In traditional medicine, soft tissue injuries are considered "tendon injuries" (or "tendon injuries"), which are closely related to "qi stagnation and blood stasis." "All tendons belong to joints" ("Inner Canon"). Tendon injuries often occur in large joints of the limbs and parts of the limbs with greater mobility. Symptoms of blood stasis and qi stagnation, swelling and pain may occur due to new injuries, old injuries, and strain, or blood stasis may not disperse and coagulate, or adhesions may occur between tissues, or tendons may contract and atrophy, becoming chronic tendon injuries that are difficult to heal, affecting limb function, and even becoming phlegm. Among them, arthritis: the invasion of wind, cold and dampness aggravates local swelling and pain (such as chronic periarthritis of the shoulder). Atrophy: long-term tendon injury and malnutrition lead to muscle atrophy (such as after peripheral nerve injury).

[0015] Tibetan medicine is a unique medical system formed through long-term practice based on the extensive absorption and integration of theories of traditional Chinese medicine, Indian medicine and Dashi medicine. It has a history of thousands of years and is one of the more complete and influential ethnic medicines in my country. Tibetan medicine focuses on the synergy of multiple drugs in the treatment of soft tissue injuries. Commonly used compound prescriptions include: 25-flavor coral pills, composed of coral, pearl, saffron, musk, etc. (some ingredients overlap with traditional Chinese medicine), efficacy: dredging collaterals and relieving pain, repairing nerve damage, suitable for chronic strain or post-traumatic nerve compression; 70-flavor pearl pills, composed of pearl, sandalwood, agarwood, bezoar, etc., efficacy: regulating qi and blood, anti-inflammatory and analgesic, often used for old soft tissue injuries with qi and blood stasis. Ruyi Treasure Pills, composed of Tibetan calamus, terminalia chebula, rhizoma jasminoides, safflower, etc., function: clearing heat and reducing swelling, promoting blood circulation and dredging collaterals, and has a significant effect on heat toxicity and blood stasis after acute sprain.

[0016] However, Tibetan medicine compound prescriptions generally have more Chinese medicinal flavors, and the drugs used often contain precious medicinal materials, and the overall cost is relatively high. There are also many famous prescriptions for treating injuries from falls in traditional Chinese medicine, such as Qilin Powder. In Qilin Powder, Xuejie is the main drug, and it is used heavily; frankincense, myrrh, etc. are used as secondary drugs; cinnabar is used as an adjuvant. However, the cost of Xuejie is relatively high; frankincense and myrrh often cause gastrointestinal discomfort; cinnabar contains mercury, which poses a safety hazard. Summary of the invention

[0017] The present invention intends to provide a new Tibetan medicine composition which has simpler drug compatibility, low cost, high drug safety and good therapeutic effect on soft tissue injuries.

[0018] Lamiophlomis rotata has good effects of promoting blood circulation to remove blood stasis, detumescence and pain relief, and hemostasis. However, if Lamiophlomis rotata is used alone, it may have adverse effects on the health of patients. The reported adverse reactions currently include symptoms such as gastrointestinal discomfort and allergic reactions. In order to ensure the efficacy of Lamiophlomis rotata and reduce the toxic and side effects on patients, the present invention is formulated with other medicinal flavors and provides a compound Tibetan medicine composition, which comprises the following raw materials in parts by weight:

[0019] 180-220 parts of Lamiophlomis rotata, 100-140 parts of Panax notoginseng, 80-120 parts of dragon's blood, 8-12 parts of artificial musk, 80-120 parts of acacia catechu, 100-140 parts of Carthamus tinctorius.

[0020] Furthermore, it comprises the following raw materials in parts by weight:

[0021] 200 parts of Lamiophlomis rotata, 120 parts of Panax notoginseng, 100 parts of dragon's blood, 10 parts of artificial musk, 100 parts of acacia catechu, 120 parts of Carthamus tinctorius.

[0022] Even further, it further comprises 80-120 parts of borneol, 18-22 parts of menthol ice, 70-110 parts of camphor.

[0023] Even further, 100 parts of borneol, 20 parts of menthol ice, 90 parts of camphor.

[0024] The formula rationale is as follows:

[0025] Lamiophlomis rotata is the monarch drug. According to the records in Tibetan medical literatures such as "Yuewang Pharmaceutical Canon", "Four Medical Tantras", "Pinzhu Materia Medica", and "Tara Materia Medica", it is transliterated as "Daba, Dabulba", etc., and has the effects of promoting blood circulation to remove blood stasis, detumescence and pain relief, and hemostasis. It is mainly used for treating traumatic injuries, external bleeding, rheumatic pain, scrofuloderma, etc. The ministers are Panax notoginseng, Carthamus tinctorius, dragon's blood, and acacia catechu to enhance the effects of promoting blood circulation to remove blood stasis, detumescence and pain relief. The assistants are borneol, camphor, and menthol ice, which are pungent, fragrant, and spreading, with the functions of aromatic resuscitation, dispelling wind, relieving itching and pain. The above medicines have greatly increased effects through wine soaking, and have the effects of promoting blood circulation, sterilizing and anti-inflammatory, relieving pain, detumescence, pain relief and itching.

[0026] Lamiophlomis rotata, the whole herb or root of the plant Lamiophlomis rotata (Benth.) Kudo of Labiatae, has the effects of hemostasis, pain relief, and granulation promotion, and is used for fractures, external bleeding, and rheumatic pain.

[0027] Panax notoginseng, the root and rhizome of the plant Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow of Araliaceae. The efficacy is promoting blood circulation to remove blood stasis and hemostasis, and it is used for traumatic injuries and internal bleeding.

[0028] Dragon's blood resin, which is the resin secreted by the fruits of Daemonorops draco (a plant of the Palmae family) (domestic dragon's blood resin is mostly the resin of Dracaena cochinchinensis of the Liliaceae family). Efficacy: Promote blood circulation and remove blood stasis, used for gynecological blood stasis, traumatic swelling and pain.

[0029] Musk, which is the secretion of the mature male musk gland of Moschus berezovskii, Moschus chrysogaster or Moschus moschiferus of the Cervidae family. Efficacy: Induce resuscitation and stimulate the meridian, used for stroke coma, febrile coma. In this invention, artificial musk is used. As a substitute for the endangered animal medicine musk, artificial musk is used in the same formula as natural musk.

[0030] Catechu, which is the extract of the peeled branches of Acacia catechu (a plant of the Leguminosae family). Efficacy: Astringe to stop bleeding, used for diarrhea, ulcers.

[0031] Sichuan safflower, which is the tubular flower of Carthamus tinctorius (a plant of the Compositae family). Efficacy: Promote blood circulation to dredge the meridian, used for amenorrhea, blood stasis abdominal pain.

[0032] Borneol, natural borneol: the volatile oil crystal of Cinnamomum camphora (a plant of the Lauraceae family) (dextrorotatory borneol);

[0033] Synthetic borneol: chemically synthesized from camphor. Efficacy: Clear heat and relieve pain, used for red and swollen eyes, throat inflammation.

[0034] Menthol (i.e., peppermint camphor), which is the extract or crystal of the volatile oil of Mentha haplocalyx (a plant of the Labiatae family), and is a saturated cyclic alcohol obtained from peppermint oil. Efficacy: Dispel wind and heat, used for headache, wind-heat cold.

[0035] Camphor, which is the extract or crystal of the volatile oil of Cinnamomum camphora (a plant of the Lauraceae family). Efficacy: Expel insects and relieve itching, externally used for skin itching, scabies.

[0036] Furthermore, it further includes wine. Wine is hot in nature, pungent, bitter and sweet in taste, and belongs to the heart, liver, stomach and lung meridians, and has the effects of dredging the meridians, warming yang and dispelling cold, guiding the medicinal properties, etc.

[0037] This invention also provides a Tibetan medicine preparation, which includes the above-mentioned Tibetan medicine composition and pharmaceutically acceptable excipients.

[0038] Furthermore, the preparation includes external preparations and oral preparations.

[0039] Even further, the external preparations include ointments, plasters, powders, tinctures, lotions, gels, cataplasms, pastes.

[0040] The present invention also provides a preparation method of a Tibetan medicine preparation, which includes the following:

[0041] (1) Take the pharmaceutical composition as described above;

[0042] (2) Extract with ethanol having a content of 30-75%, and thus obtain.

[0043] The present invention also provides the use of the Tibetan medicine composition as described above or the Tibetan medicine preparation as described above in the preparation of a medicament for treating acute or chronic soft tissue injuries.

[0044] The present invention also provides the use of the Tibetan medicine composition as described above or the Tibetan medicine preparation as described above in the preparation of a medicament for treating traumatic injuries, sprains, falls, cervical and lumbar hyperosteogeny, scapulohumeral periarthritis, and rheumatic arthritis.

[0045] During the use of the present invention, it was also unexpectedly found that the Tibetan medicine composition as described above or the Tibetan medicine preparation as described above has a therapeutic effect on acne, acute or chronic urticaria, skin pruritus, herpes zoster, furuncle, mosquito bites, chickenpox, and bedsore. Furthermore, the present invention also provides:

[0046] The use of the Tibetan medicine composition as described above or the Tibetan medicine preparation as described above in the preparation of a medicament for treating acne, acute or chronic urticaria, skin pruritus, herpes zoster, furuncle, mosquito bites, chickenpox, and bedsore.

[0047] Beneficial effects:

[0048] (1) The Tibetan medicine composition of the present invention can promote blood circulation, sterilize and reduce inflammation, relieve pain, reduce swelling and relieve pain, is convenient to use, has a wide range of diseases to be treated, and has definite curative effects.

[0049] (2) In the present invention, by using Panax notoginseng, dragon's blood and other medicinal flavors in combination with Lamiophlomis rotata, the dosage of Lamiophlomis rotata is reduced. Not only the toxic and side effects caused by large doses of Lamiophlomis rotata are avoided, but also good therapeutic effects are brought, and the scope of medical uses is expanded, and other various diseases can be treated.

[0050] (3) Compared with the traditional Tibetan medicine composition, the number of medicinal flavors of the composition of the present invention is controlled within 10 flavors, and the compatibility and production are more convenient, and the cost is also lower.

[0051] (4) Compared with traditional Chinese medicine prescriptions such as Qili Powder, in the composition of the present invention, dragon's blood is no longer the monarch drug, the usage amount of dragon's blood is reduced, and the monarch drug uses Lamiophlomis rotata with a lower price, effectively reducing the medication cost of patients; at the same time, the composition of the present invention avoids using frankincense and myrrh, thereby effectively avoiding the side effects brought by these drugs; avoiding using cinnabar also makes the product safer. Detailed implementation manners

[0052] The technical solutions of the present invention will be described clearly and completely below. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0053] The term "treatment" refers to prophylactic (e.g., prophylactic medication), curative or palliative treatment. Specifically, treatment herein refers to the administration or dosing of the pharmaceutical composition or formulation described in the present invention to an individual who may have a medical disorder, symptoms associated with the disorder, secondary diseases or abnormalities of the disorder, or who is predisposed to the above-mentioned disorder, in order to partially or completely alleviate, improve, relieve one or more symptoms or characteristics of a particular abnormality and / or disease condition, or to delay its occurrence, impede its progression, reduce its severity and / or reduce its incidence. Treatment may also be carried out on individuals who have not yet shown signs of a disease, abnormality and / or disease condition and / or individuals who have shown early signs, in order to reduce the risk of developing pathological changes associated with the disease, abnormality and / or disease condition.

[0054] In the present invention, an "individual" refers to a mammal, including a human, who can receive the pharmaceutical composition or formulation described in the present invention. Unless otherwise specified, the terms "administration" and "dosing" are used interchangeably herein, and refer to providing the pharmaceutical composition or formulation described in the present invention to an individual in need of treatment.

[0055] In the present invention, an "effective dose" is an amount of the pharmaceutical composition sufficient to elicit the desired therapeutic response. The effective dose of the agent does not have to be able to cure the disease or disorder, but can delay, impede or prevent the occurrence of the disease or disorder, or can alleviate the symptoms associated with the disease or disorder. The therapeutically effective dose can be divided into one, two or more doses and administered one, two or more times at appropriate intervals in a suitable dosage form. The specific therapeutically effective dose or sufficient dose depends on various factors, such as the specific condition to be treated, the physiological condition of the individual (e.g., the weight, age or sex of the individual), the type of mammal or animal being treated, the duration of treatment, the nature of concurrent treatments (if any), and the specific formulation and structure of the active ingredient used. The effective amount can be expressed in any suitable manner, for example, it can be expressed as the total weight of the pharmaceutical composition (e.g., in grams, milligrams or micrograms) or as the ratio of the pharmaceutical composition to body weight (e.g., expressed as milligrams per kilogram of body weight (mg / kg)).

[0056] Ointment. Characteristics: A semi-solid topical preparation with appropriate viscosity, easy to spread and absorb. Preparation method: (1) Fusion method: Heat and melt the matrix (such as petrolatum, beeswax), add fine powder or extract of the drug, stir evenly, and cool to form. (2) Levigation method: Grind the fine powder of the drug evenly with a small amount of liquid matrix (such as glycerol), and then gradually add the remaining matrix and mix. Commonly used excipients: Matrix: Petrolatum, lanolin, beeswax, liquid paraffin, glycerol.

[0057] Plaster (black plaster, white plaster). Characteristics: A patch type with long-lasting drug effect, mostly used for joint pain and traumatic injury. Preparation method of black plaster: (1) Frying the ingredients: Fry the medicinal materials with vegetable oil (such as sesame oil) until they turn brown and remove the residue by filtration; (2) Refining the oil: Continue to heat until the oil drops form beads (about 300 °C). (3) Adding lead dioxide: Add lead dioxide (Pb 3 O 4 )), stir until the saponification reaction is completed to form a black paste. (4) Removing the fire poison: Immerse the plaster in cold water or leave it for several days to remove irritation. (5) Spreading: Spread it on a cloth or paper substrate. Conventional excipients: Vegetable oil (sesame oil), lead dioxide.

[0058] Preparation method of white plaster: Using vegetable oil and lead soap (such as lead stearate) as the matrix, add the drug extract, mix and spread. Conventional excipients: Vegetable oil, lead soap, drug extract.

[0059] Powder (topical powder). Characteristics: In powder form, can be directly sprinkled or applied to the affected area after mixing. Preparation method: Crush the medicinal materials and sieve (80 - 100 mesh), mix evenly; sterilize (by ultraviolet or dry heat sterilization). Conventional excipients: Diluent: Talc powder, calcined gypsum; Absorption promoter: Borneol, menthol (a small amount).

[0060] Tincture. Characteristics: A liquid preparation in which the drug is dissolved in ethanol or vinegar, with strong permeability. Preparation method: (1) Maceration method: Crush the medicinal materials and soak them in ethanol or vinegar for 7 - 14 days, filter to obtain the liquid. (2) Percolation method: Pack the medicinal materials in a column, and the solvent slowly percolates for extraction. Conventional excipients: Ethanol (concentration 50% - 75%), vinegar.

[0061] Lotion (liniment, lotion for fumigation and washing). Characteristics: Liquid or semi-fluid, used for cleaning or wet compress. Preparation method: (1) Decoct and concentrate the medicinal materials, or directly dissolve them in the solvent. (2) Add solubilizer (such as Tween - 80) or preservative (such as sodium benzoate). Conventional excipients: Solvent: Water, ethanol, glycerol; Thickening agent: Carboxymethyl cellulose sodium (CMC - Na).

[0062] Gel. Characteristics: Transparent or semi - transparent jelly - like, suitable for mucous membranes or skin. Preparation method: After swelling the water - soluble matrix (such as carbomer), add the drug and neutralizing agent (such as triethanolamine) to form a gel. Conventional excipients: Carbomer, glycerol, propylene glycol, hydroxypropyl methylcellulose (HPMC).

[0063] Patch (cataplasm, rubber plaster), characteristics: convenient for application, slow release of drug efficacy. Preparation method of cataplasm:

[0064] Mix the drug with a hydrophilic matrix (such as gelatin, sodium polyacrylate); coat it on non-woven fabric or elastic fabric, and cover with a release liner. Conventional excipients: gelatin, glycerin, kaolin, sodium polyacrylate. Preparation method of rubber plaster: Mix the rubber matrix (natural rubber) with the drug, and add a tackifier (rosin); coat it on the backing material, and cover with a release liner. Conventional excipients: natural rubber, zinc oxide, rosin.

[0065] Paste, characteristics: a mixture of high-concentration powder and matrix, with a higher viscosity than ointment. Preparation method: (1) Mix fine powder of the drug (25% - 50%) with vaseline, liquid paraffin, etc.; (2) Stir until evenly pasty. Conventional excipients: vaseline, liquid paraffin, zinc oxide.

[0066] "Ethanol with a content of 30 - 75%", its concentration includes but is not limited to 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%. The "ethanol with a content of 30 - 75%" described in the present invention can be directly used as edible wine, or can be prepared using medical ethanol.

[0067] For the edible wine described in the present invention, the alcohol content can be selected from the common alcohol contents on the market, such as 28 degrees, 33 degrees, 35 degrees, 38 degrees, 39 degrees, 40 degrees, 42 degrees, 43 degrees, 45 degrees, 48 degrees, 50 degrees, 52 degrees, 53 degrees, 56 degrees, 60 degrees, and 68 degrees.

[0068] In the present invention, for the extraction of the active pharmaceutical ingredient, conventional extraction methods include but are not limited to:

[0069] 1. Decoction method

[0070] Soak the medicinal materials in water, then boil, keep slightly boiling for a certain time, filter to obtain the medicinal liquid, repeat decocting 1 - 3 times, and combine the filtrates.

[0071] 2. Maceration method

[0072] Crush the medicinal materials and soak them in a solvent, let stand for several days to several weeks (cold maceration or warm maceration), stir regularly, and filter to obtain the liquid.

[0073] Solvent: water, ethanol, or ethanol - water mixture.

[0074] Advantages: Simple equipment, suitable for heat-sensitive components (such as volatile oils).

[0075] 3. Percolation method

[0076] The medicinal materials are loaded into a column, and the solvent slowly percolates through the medicinal material layer from top to bottom, and the percolate is collected dynamically.

[0077] Solvents: Ethanol, acidic / alkaline aqueous solutions.

[0078] Advantages: Continuous dynamic extraction, higher efficiency than the maceration method, suitable for lipophilic components (such as alkaloids).

[0079] 4. Reflux extraction method

[0080] The medicinal materials and the solvent are heated to boiling in a round-bottom flask, and the solvent vapor is condensed and refluxed to the flask for cyclic extraction.

[0081] Solvents: Organic solvents such as ethanol, methanol, and chloroform.

[0082] Advantages: High extraction efficiency, suitable for heat-stable components (such as flavonoids, terpenoids).

[0083] 5. Soxhlet extraction (continuous reflux extraction)

[0084] Using a Soxhlet extractor, the solvent is repeatedly distilled and condensed to extract the medicinal materials cyclically.

[0085] Low-boiling organic solvents such as ether and petroleum ether.

[0086] Advantages: Solvent recycling, suitable for a small amount of lipophilic components (such as oils and volatile oils).

[0087] 6. Ultrasonic-assisted extraction

[0088] After the medicinal materials and the solvent are mixed, the cell walls are broken by ultrasonic cavitation to accelerate the dissolution of the components.

[0089] Solvents: Water, ethanol, etc.

[0090] Advantages: Fast (dozens of minutes), efficient, energy-saving, suitable for heat-sensitive components.

[0091] 7. Supercritical fluid extraction (SFE)

[0092] Using supercritical CO 2 dissolves the components of the medicinal materials under high pressure, and CO 2 vaporizes and separates after decompression.

[0093] Solvent: Supercritical CO 2 (Entrainers such as ethanol can be added).

[0094] Advantages: No solvent residue, environmentally friendly, suitable for high-value-added components (such as essential oils, terpenoids).

[0095] 8. Microwave-assisted extraction

[0096] The medicinal materials and the solvent are heated by microwave, and the temperature inside the cells rises rapidly and ruptures, releasing the components.

[0097] Solvent: Polar solvents such as water and ethanol.

[0098] Advantages: Fast (within a few minutes), highly selective, energy-saving.

[0099] 9. Enzymatic hydrolysis method

[0100] Using cellulase, pectinase, etc. to decompose the cell wall and release the intracellular components.

[0101] Solvent: Water or buffer solution.

[0102] Advantages: Mild conditions, improving the extraction rate of polysaccharides and proteins.

[0103] Example 1 Preparation of the liniment of the present invention

[0104] Prescription composition: 200 g of Lamiophlomis rotata, 120 g of Panax notoginseng, 100 g of Dragon's blood, 10 g of Artificial musk, 100 g of Catechu, 120 g of Safflower carthamus, 100 g of Borneol, 20 g of Menthol ice, 90 g of Camphor

[0105] Preparation method:

[0106] Soak the above components in 53% white liquor, soak and extract at room temperature, and take the clarified liquid to obtain.

[0107] Appearance: This product is a tea-yellow smear liquid.

[0108] Example 2 Preparation of the liniment of the present invention

[0109] Prescription composition: 220 g of Lamiophlomis rotata, 100 g of Panax notoginseng, 80 g of Dragon's blood, 8 g of Artificial musk, 80 g of Catechu, 100 g of Safflower carthamus, 80 g of Borneol, 18 g of Menthol ice, 80 g of Camphor

[0110] Preparation method:

[0111] Soak the drugs separately in 52% white liquor, soak and extract at room temperature, and take the clarified liquid to obtain.

[0112] Appearance: This product is a tea-yellow smear liquid.

[0113] Example 3 Preparation of the liniment of the present invention

[0114] Composition of the prescription: 180 g of Herba Lamiophlomis Rotata, 140 g of Radix Notoginseng, 120 g of Sanguis Draxonis, 12 g of Moschus Artificialis, 120 g of Catechu, 140 g of Flos Carthami, 120 g of Borneolum Syntheticum, 22 g of Mentholum Crystallinum, 110 g of Camphora

[0115] Preparation method:

[0116] Soak the above components in 42% white liquor, extract by soaking at room temperature, and take the clarified liquid to obtain.

[0117] Appearance: This product is a tea-yellow smear liquid.

[0118] Example 4 Preparation of the liniment of the present invention

[0119] Composition of the prescription: 190 g of Herba Lamiophlomis Rotata, 110 g of Radix Notoginseng, 110 g of Sanguis Draxonis, 12 g of Moschus Artificialis, 110 g of Catechu, 110 g of Flos Carthami, 110 g of Borneolum Syntheticum, 20 g of Mentholum Crystallinum, 80 g of Camphora

[0120] Preparation method:

[0121] Soak the above components in 38% white liquor, extract by soaking at room temperature, and take the clarified liquid to obtain.

[0122] Appearance: This product is a tea-yellow smear liquid.

[0123] Example 5 Preparation of the liniment of the present invention

[0124] Composition of the prescription: 200 g of Herba Lamiophlomis Rotata, 120 g of Radix Notoginseng, 100 g of Sanguis Draxonis, 10 g of Moschus Artificialis, 100 g of Catechu, 120 g of Flos Carthami, 100 g of Borneolum Syntheticum, 20 g of Mentholum Crystallinum, 90 g of Camphora

[0125] Preparation method:

[0126] Soak the above components in 28% white liquor, extract by soaking at room temperature, and take the clarified liquid to obtain.

[0127] Appearance: This product is a tea-yellow smear liquid.

[0128] Example 6

[0129] Since 1992, the inventor has used the self-made liniment (prepared in Example 1) to treat soft tissue injuries and the relatively satisfactory results are reported as follows.

[0130] 1. Statistical data of part of the cases:

[0131] Among 226 cases, there are 160 males and 66 females, aged 19 - 54 years old; the longest course of disease is 3 years and the shortest is 1 day, among which there are 180 cases of acute soft tissue injuries and 46 cases of chronic soft tissue injuries.

[0132] 2. Treatment method

[0133] Apply the liniment prepared in Example 1 externally by rubbing it on the affected area of the patient several times a day, and perform local massage for 5 - 8 minutes for various pains.

[0134] 3. Treatment Results

[0135] Among 226 cases, 151 cases were cured (symptoms and signs completely disappeared, and functions returned to normal), accounting for 67%; 70 cases showed improvement (symptoms and signs basically disappeared, but there were still some limitations in functions), accounting for 31%; 5 cases were ineffective (symptoms, signs, and functions showed no obvious improvement), accounting for 2%. The total effective rate was 97%. No patient reported side effects such as gastrointestinal discomfort or allergic reactions.

[0136] 4. Data Statistics

[0137] Cured Improved Invalid Total effective rate Number of patients 151 cases 70 cases 5 cases Proportion 67％ 31％ 2％ 98％

[0138] 5. Typical Cases

[0139] (1) Wang, female, 46 years old. First diagnosis on March 10, 1992. She had soreness and pain in the right elbow and weakness in the right forearm for 3 years. The patient suffered an elbow injury 3 years ago. In the past 3 years, there has been soreness, pain, and weakness in the outer side of the right elbow and forearm. The pain is obvious when the forearm makes stretching, pronation, and supination movements. The right hand cannot bear weight. She has taken traditional Chinese medicine, received physiotherapy, and applied plasters externally, but all were ineffective. Examination: There was obvious tenderness at the lateral epicondyle of the right humerus. The pain was aggravated when the wrist joint flexed and extended and the forearm rotated. There was obvious tenderness along the course of the extensor carpi radialis muscle, and it felt dull and thick when touched. Diagnosis: Old soft tissue injury of the right elbow. The liniment of the present invention was used for treatment with the techniques of separating tendons, regulating tendons, massaging, kneading, and rubbing. After one course of treatment, the symptoms disappeared, the joint activity of the right elbow was normal, and there has been no recurrence so far.

[0140] (2) Luo, male, 45 years old. First diagnosis on October 20, 1998. He had a sprained right ankle joint, with swelling, pain, and inability to walk for 3 days. 3 days ago, he accidentally sprained his right foot when going down the stairs. Immediately afterwards, he felt swelling and pain in the ankle joint, with skin ecchymosis and functional impairment. No fracture was seen on the X-ray film of the ankle joint. Diagnosis: Acute soft tissue injury of the right ankle joint. The liniment of the present invention was used for treatment with the techniques of pushing, grasping, pressing, and kneading, once every other day. After 3 treatments, he was cured.

[0141] (3) Guo, male, 56 years old, first visit on June 6, 2002, with difficulty sitting, lying, and walking due to low back pain for 1 day. When the patient leaned forward and reached out his left hand to pick up a pen in the office, he suddenly felt a sharp stabbing pain in the waist, and then assumed a forced position. He could not move his waist freely and was supported by others to go home and lie in bed. He had difficulty turning over. After applying hot compress, there was a slight improvement. The next day, he could not sit up and needed to be supported. The lower back was weak and could not support his body. He came to the clinic by car. Supported by two people, he could not stand up by himself. The waist was tender and rigid to the touch. No other abnormalities were found. Diagnosis: Acute lumbar sprain. The liniment of the present invention was used with pushing, kneading, pressing, rubbing, and tendon-stroking techniques. After 15 minutes, the patient felt comfortable, could sit up by himself, and walked out of the diagnosis room on foot. He was very happy. Then, the treatment was given once every other day. After 3 treatments, the patient was cured.

[0142] Example 7: Mosquito bites

[0143] Xia, female, 24 years old, visited on June 3, 2003. After being bitten by a mosquito on the right forearm, there was swelling, itching, and discomfort. Scratches could be seen on the forearm. After applying Yicaling several times externally, the swelling and itching disappeared two days later.

[0144] Example 8: Acute and chronic urticaria

[0145] Wang, male, 14 years old, on July 6, 2003

[0146] Description: For four years, the whole body has often had recurrent wheals. In the past three days, it has flared up again, being more severe in the morning and evening. Examination: On the trunk and limbs, there were pink wheal-like flat rashes of different sizes and shapes, with a surrounding red halo, slightly hard to the touch, and some rashes merged into large patches. Scratches and blood scabs could be seen. Diagnosis: Chronic urticaria, acute attack. Came to our clinic for treatment. Instructed to apply Yicaling externally several times a day. After three days, the wheals gradually disappeared and there was no more itching. It was basically cured.

[0147] Example 9: Acne

[0148] Hu, male, 31 years old, visited on February 12, 2004. He reported that there were papules on both cheeks, the head, and the back of the face, with white tops. After squeezing, there was white secretion. It recurred repeatedly. Diagnosis: Acne vulgaris. After applying Yicaling externally for four weeks and taking oral traditional Chinese medicine to nourish yin and clear heat and detoxify, the papules on the face disappeared.

[0149] Example 10: Chickenpox

[0150] Fan, male, 10 years old, visited on March 11, 2004. After having a fever for one day and the body temperature returning to normal after antipyretic treatment, multiple chickenpox appeared on the limbs and trunk, with itching and discomfort. Diagnosed with chickenpox. After applying Yicaling externally for treatment, the chickenpox disappeared and the patient was cured after one week.

[0151] Example 11: Herpes zoster

[0152] Li, male, 23 years old, visited the doctor on May 11, 2004. There were blisters on the right lower chest accompanied by severe pain for five days. Initially, there was pain in the right lower chest, and then erythema and blisters appeared successively, presenting in patches and spreading from the front chest to the back chest. The pain was severe and made it impossible to sleep at night. Physical examination showed scattered and densely clustered blisters of different sizes between the 7th, 8th, and 9th intercostal spaces on the right chest. The base was a purplish-red erythema, congested, with a slightly red infiltration around it. There was no ulceration or erosion surface. The diagnosis was herpes zoster, with damp-heat in the liver and gallbladder. He was given internal medications to clear and remove damp-heat in the liver and gallbladder, and externally applied Yicaling several times a day. After one week of treatment, the pain was significantly relieved and he could sleep. The local herpes had dried, crusted, and fallen off. Subsequently, the treatment method was to promote diuresis, strengthen the spleen, and clear heat, with external application of Yicaling several times a day. After the follow-up visit, other symptoms disappeared, with only surface pigmentation, and no recurrence was seen.

[0153] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Tibetan medicine composition, characterized in that: The raw materials include the following parts by weight: 180-220 parts of Radix Angelicae Pubescentis, 100-140 parts of Radix Notoginseng, 80-120 parts of Sanguisorba Officinalis, 8-12 parts of artificial musk, 80-120 parts of catechu, and 100-140 parts of safflower.

2. The Tibetan medicine composition according to claim 1, characterized in that: The raw materials include the following parts by weight: 200 parts of Radix Angelicae Pubescentis, 120 parts of Radix Notoginseng, 100 parts of Sanguisorba Officinalis, 10 parts of artificial musk, 100 parts of catechu, and 120 parts of safflower.

3. The Tibetan medicine composition according to claim 1 or 2, characterized in that: It also includes 80-120 parts of borneol, 18-22 parts of menthol ice, and 70-110 parts of camphor.

4. The Tibetan medicine composition according to claim 3, characterized in that: 100 parts of borneol, 20 parts of mint ice, 90 parts of camphor.

5. The Tibetan medicine composition according to any one of claims 1 to 4, characterized in that: Wine is also included.

6. A Tibetan medicine preparation, characterized in that: It comprises the Tibetan medicine composition according to any one of claims 1 to 5 and pharmaceutically acceptable adjuvants; further, the preparation comprises an external preparation and an oral preparation; further, the external preparation comprises an ointment, a plaster, a powder, a tincture, a lotion, a liniment, a gel, a plaster and a paste.

7. A method for preparing a Tibetan medicine preparation, characterized in that: It includes the following: (1) The pharmaceutical composition according to any one of claims 1 to 5; (2) Extract with 30-75% ethanol to obtain the product.

8. Use of the Tibetan medicine composition according to any one of claims 1 to 5 or the Tibetan medicine preparation according to any one of claims 6 to 8 in the preparation of a medicament for treating acute or chronic soft tissue injuries.

9. Use of the Tibetan medicine composition according to any one of claims 1 to 5 or the Tibetan medicine preparation according to any one of claims 6 to 8 in the preparation of medicines for treating traumatic injuries, sprains, falls, cervical and lumbar vertebrae hyperosteogeny, scapulohumeral periarthritis, and rheumatoid arthritis.

10. Use of the Tibetan medicine composition according to any one of claims 1 to 5 or the Tibetan medicine preparation according to any one of claims 6 to 8 in the preparation of medicines for treating acne, acute or chronic urticaria, skin itching, herpes zoster, furuncle, insect bites, chickenpox, and bedsores.