Preparation method and application of bletilla striata polysaccharide modified nanocrystal-loaded microneedle
Through the preparation method of nanocrystalline microneedle modified with Bletilla polysaccharide, the problem of microneedle administration destroying skin integrity and increasing the risk of allergic infection is solved, and the effect of improving transdermal absorption and reducing the risk of allergic infection is achieved.
CN120168389APending Publication Date: 2025-06-20JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information
- Application Number
- CN202510152821.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-12
- Publication Date
- 2025-06-20
AI Technical Summary
Technical Problem
The existing microneedle administration methods destroy the integrity of the skin and increase the risk of skin allergies and infections.
Method used
The preparation method of nanocrystalline microneedle modified with Bletilla polysaccharide is used to mix the punctyl lactone nanocrystalline with Bletilla polysaccharide to form a needle solution, and the matrix solution is placed in the mold to form a microneedle.
Benefits of technology
It improves transdermal absorption, reduces the risk of skin allergies and infections, and promotes the healing of holes caused by puncture.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides a preparation method and application of a bletilla striata polysaccharide modified nanocrystal-loaded microneedle, and the preparation method comprises the following steps: preparing andrographolide, first polyvinylpyrrolidone, polyvinyl alcohol and a first bearing liquid into a concentrated crystal suspension, and uniformly suspending andrographolide nanocrystals in the concentrated crystal suspension; mixing the concentrated and crystallized suspension and bletilla striata polysaccharide to obtain a needle solution; mixing second polyvinylpyrrolidone, glycerol and a second bearing solution to obtain a substrate solution; and putting the needle head solution and the matrix solution into a mold to form the bletilla striata polysaccharide modified nanocrystal-loaded microneedle. Experiments show that by adding the bletilla striata polysaccharide to form the needle solution, the healing rate of holes caused by puncture is effectively improved, and the risks of skin allergy and infection are avoided.
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