Sanitary pest control concentrated composition and application thereof

Abstract

The invention relates to the technical field of sanitary pest killing, in particular to a sanitary pest control concentrated composition and application thereof. The sanitary pest control concentrated composition is prepared from the following components in percentage by mass: 10-50% of an active component A and an active component B, 10-40% of a feeding accelerant, 5-15% of a macromolecular humectant, 5-15% of a macromolecular thickener and other auxiliary materials, the active component A is selected from one or more of clothianidin, dinotefuran and sulfoxaflor; and the active component B is selected from one or more of chlorfenapyr, chlorfenapyr bisamide, metafluzamide and tetrachlorantraniliprole. According to the sanitary pest control concentrated composition, through reasonable compounding of the active components and performance combination of the preferable feeding accelerant, the preferable high-molecular humectant and the preferable high-molecular thickening agent, increase of effective components retained on the surface and improvement of surface moisture retention and palatability are achieved, the quick-acting and long-term persistent effect of the product is obviously improved, and the sanitary pest control concentrated composition is suitable for being applied to the field of agricultural products. The killing effect of the effective components on target pests is fully exerted.

Description

Technical Field

[0001] This application relates to the technical field of hygienic insecticides, and particularly relates to a concentrated composition for controlling hygienic pests and its application. Background Art

[0002] For a long time, the dosage forms and components for controlling hygienic pests have been relatively single, mainly including emulsifiable concentrates, emulsions, microemulsions of the space spraying type, wettable powders, suspensions, water dispersible granules of the residual spraying type, etc.; the active ingredients mainly include pyrethroid insecticides, organophosphorus insecticides, neonicotinoid insecticides, carbamate insecticides. The long-term repeated use of conventional dosage forms and active ingredients has greatly enhanced the pest resistance, especially the resistance development of mosquitoes and flies is very rapid. There is an urgent need for new active ingredients and formulation types for controlling resistant hygienic pests.

[0003] The agents of the space spraying type require the active ingredients to have excellent contact or fumigation properties, and the agents of the residual spraying type require the active ingredients to have excellent contact properties. This limits the excellent residual and long-lasting insecticidal properties of stomach poison active ingredients through spraying.

[0004] During the research process, we found that clothianidin, dinotefuran, sulfoxaflor have excellent rapid stomach poison knockdown effects on resistant hygienic pests, and chlorfenapyr, broflanilide, thiazolezolylamide, tetrachlorantraniliprole have excellent stomach poison lethal effects on resistant hygienic pests. The above components can exhibit obvious activity on non-absorbent surfaces, but the activity is not ideal on absorbent surfaces.

[0005] There is an urgent need in this field to break through the limitations of the performance of active ingredients by conventional dosage forms such as emulsifiable concentrates, emulsions, microemulsions, suspensions, wettable powders, water dispersible granules, baits, etc., so that the active ingredients that are difficult to exert excellent hygienic pest control effects can be effectively and efficiently applied, achieving excellent control effects on hygienic pests, especially resistant pests. Summary of the Invention

[0006] The purpose of the present invention is to overcome the problems existing in the prior art, and provide a concentrated composition for controlling hygienic pests. Through the synergistic effect of reasonable combination of active ingredients, and the performance combination of feeding promoters, high molecular weight humectants, and high molecular weight thickeners, excellent control effects on hygienic pests, especially resistant pests, are achieved. It can effectively control hygienic pests such as mosquitoes, flies, cockroaches, termites, ants, fleas, bedbugs, especially resistant mosquitoes and flies.

[0007] This application provides a concentrated composition for controlling hygienic pests. The components of the concentrated composition and their mass percentages are as follows:

[0008]

[0009]

[0010] The mass ratio of the active ingredient A and the active ingredient B is 1:9 - 9:1;

[0011] The active ingredient A is selected from one or more of clothianidin, dinotefuran, and sulfoxaflor;

[0012] The active ingredient B is selected from one or more of chlorfenapyr, broflanilide, flubendiamide, and tetrachlorantraniliprole;

[0013] The feeding promoter is selected from the compound of protein components and sugar components;

[0014] The high molecular weight humectant is selected from one or more of polyethylene glycol, polyglycerol, chitin hydrochloride, chitosan quaternary ammonium salt, and hyaluronic acid;

[0015] The high molecular weight thickener is selected from one or more of sodium carboxymethyl cellulose, sodium carboxymethyl starch, xanthan gum, locust bean gum, and konjac gum.

[0016] In this application, through the compound synergism of two groups of active ingredients A and B, and then assisted by the performance combination of a specific feeding promoter with excellent palatability, a high molecular weight humectant, and a high molecular weight thickener, the efficient exertion of the activity of the above-mentioned active ingredients on the absorption surface can be achieved. Among them, the high molecular weight thickener can make the preparation have a certain viscosity after dilution, and can greatly improve the surface retention amount after being sprayed on the absorbent surface; among them, the high molecular weight humectant, on the one hand, enhances the stomach toxicity activity through the attraction of water to the target, and on the other hand, can fully exert the contact toxicity activity of active ingredients such as chlorfenapyr, broflanilide, flubendiamide, and tetrachlorantraniliprole that have both stomach toxicity and contact toxicity through the slightly wet surface state; among them, the feeding promoter further exerts the stomach toxicity activity of the active ingredients through the surface retention of the high molecular weight thickener and the high molecular weight humectant.

[0017] Furthermore, the mass percentage of the active ingredient A and the active ingredient B is 20 - 40%; preferably 30%. The active ingredient A is clothianidin, and the active ingredient B is broflanilide. The mass ratio of the active ingredient A and the active ingredient B is 1:1 - 5:1, preferably 2:1 - 3:1.

[0018] Further, the mass percentage of the feeding promoter is 20 - 35%, preferably 35%. The feeding promoter is selected from the compound of protein components such as soy protein isolate, yeast extract, tryptone or beef peptone, and carbohydrate components such as glucose, fructose, lactose, sucrose or maltose. Preferably, it is the compound of protein components such as soy protein isolate, yeast extract, and carbohydrate components such as glucose, sucrose. More preferably, it is the compound of soy protein isolate and sucrose. The mass ratio of the protein component to the carbohydrate component in the feeding promoter is 1:1 - 1:3, preferably 2:5.

[0019] Further, the mass percentage of the high - molecular humectant is 8 - 10%; preferably 10%. The high - molecular humectant is a compound of polyglycerol and quaternary ammonium salt of chitosan. The mass ratio of polyglycerol to quaternary ammonium salt of chitosan is 2:1 - 1:2, preferably 1:1.

[0020] Further, the mass percentage of the high - molecular thickener is 8 - 10%; preferably 8%. The high - molecular thickener is a compound of sodium carboxymethyl cellulose and xanthan gum. The mass ratio of sodium carboxymethyl cellulose to xanthan gum is 2:1 - 1:2, preferably 1:1.

[0021] Further, the other excipients are selected from surfactants and fillers, and optionally acid - base regulators, defoamers. The mass fraction of the surfactant is 5 - 15%, preferably 9 - 10%. The surfactant is selected from one or more of alkyl sulfonates, alkyl benzene sulfonates, alkyl naphthalene sulfonates, alkyl sulfosuccinates, polycarboxylates, alkyl sulfonates, lignin sulfonates, naphthalene sulfonate formaldehyde condensates, alkylphenol polyoxyethylene ethers, sorbitan fatty acid esters and their ethylene oxide adducts, styrylphenol polyoxyethylene ethers, ethylene oxide - propylene oxide block copolymers, fatty alcohol polyoxyethylene ethers, castor oil polyoxyethylene ethers, polyether phosphate salts, polyether sulfate salts. The surfactant is preferably alkyl benzene sulfonate and naphthalene sulfonate formaldehyde condensate. The mass ratio of the alkyl benzene sulfonate to the naphthalene sulfonate formaldehyde condensate is 1:1 - 1:2.

[0022] The filler is selected from one or more of silica white, kaolin, acid clay, bentonite, talc powder, calcium carbonate, diatomaceous earth, ammonium chloride, ammonium sulfate, sodium sulfate, potassium sulfate, urea, etc. The filler is preferably silica white. The other excipients also include necessary acid - base regulators such as citric acid, benzoic acid, oxalic acid, and necessary defoamers such as silicone defoamers, polyether defoamers, fatty acid and its ester defoamers, etc.

[0023] The concentrated composition for controlling resistant sanitary pests described in the present application is a powder.

[0024] The present invention also provides a preparation method of a concentrated composition for controlling resistant sanitary pests, comprising the following steps:

[0025] (1) Mix the active ingredient A, active ingredient B, and other excipients evenly, and obtain the mother powder by air jet milling.

[0026] (2) Mix the mother powder, feeding promoter, high molecular humectant, and high molecular thickener again and stir evenly, and obtain the insecticidal product by high-speed milling or air jet milling.

[0027] The present application also provides the use of the concentrated composition for controlling sanitary pests, which is used for controlling sanitary pests; the sanitary pests are preferably mosquitoes, flies, cockroaches, termites, ants, fleas, bed bugs, especially resistant mosquitoes and flies.

[0028] The concentrated composition for controlling sanitary pests described in the present application controls sanitary pests by spraying and residual spraying; preferably, the concentrated composition for controlling sanitary pests is diluted with water before use. The concentrated composition can be diluted 1000 times with water for spraying at a dose of 25 mg / m 2 or the concentrated composition can be sprayed on the surfaces of objects such as walls, doors, windows, ceilings, and furniture at a dose of 100 mg / m 2 after being diluted 500 times, so that the sanitary insecticide remains on the surfaces of the above-mentioned objects, achieving the effects of knocking down and killing sanitary pests.

[0029] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0030] (1) Compared with conventional pesticide formulations such as emulsifiable concentrates, suspensions, wettable powders, water-dispersible granules, etc., it has a more excellent surface retention effect of the active ingredient, and can give full play to the contact killing and stomach toxicity effects of the active ingredient.

[0031] (2) Through the synergistic effect of the reasonable combination of active ingredients, the product can more effectively achieve the effective control of sanitary pests, especially resistant target pests.

[0032] (3) Using a high molecular thickener increases the retention amount of the active ingredient on the treated surface after dilution, improves the utilization rate of the active ingredient, and enhances the killing effect of the active ingredient.

[0033] (4) Assisted by a high molecular humectant, it overcomes the defect that it is difficult to exert the contact killing activity of the active ingredient after the thickener dries into a film.

[0034] (5) Assisted by a feeding promoter, it further enhances the stomach toxicity killing performance of the surface-retained active ingredient.

[0035] (6) It adds a new compound composition and formulation design method to the domestic sanitary insecticide field, with significant drug effects and can be widely promoted and applied. Detailed implementation mode

[0036] The present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited to these specific embodiments. Those skilled in the art should recognize that the present invention covers all alternative solutions, improvement solutions, and equivalent solutions that may be included within the scope of the claims.

[0037] I. Formulation Examples

[0038] Formulation Example 1:

[0039] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D - 425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0040] Formulation Example 2:

[0041] 22.5 g of clothianidin, 7.5 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D - 425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0042] Formulation Example 3:

[0043] 25 g of clothianidin, 5 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D - 425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0044] Formulation Example 4:

[0045] 27 g of clothianidin, 3 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D - 425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0046] Formulation Example 5:

[0047] 15 g of clothianidin, 15 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air jet milling to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0048] Formulation Example 6:

[0049] 10 g of clothianidin, 20 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air jet milling to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0050] Formulation Example 7:

[0051] 5 g of clothianidin, 25 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air jet milling to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0052] Formulation Example 8:

[0053] 3 g of clothianidin, 27 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air jet milling to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0054] Formulation Example 9:

[0055] 30 g of clothianidin, 10 g of chlorfenapyr, 3 g of sodium dodecylbenzenesulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 15 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air jet milling to obtain a 40% clothianidin·chlorfenapyr concentrated preparation product.

[0056] Formulation Example 10:

[0057] Take 20 g of clothianidin, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white. After airflow pulverization, a 30% clothianidin·chlorfenapyr concentrated preparation product is obtained.

[0058] Formulation Example 11:

[0059] Take 20 g of clothianidin, 10 g of thiazolezolamide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white. After airflow pulverization, a 30% clothianidin·thiazolezolamide concentrated preparation product is obtained.

[0060] Formulation Example 12:

[0061] Take 20 g of clothianidin, 10 g of tetrachlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white. After airflow pulverization, a 30% clothianidin·tetrachlorantraniliprole concentrated preparation product is obtained.

[0062] Formulation Example 13:

[0063] Take 20 g of dinotefuran, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white. After airflow pulverization, a 30% dinotefuran·broflanilide concentrated preparation product is obtained.

[0064] Formulation Example 14:

[0065] Take 20 g of dinotefuran, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white. After airflow pulverization, a 30% dinotefuran·chlorfenapyr concentrated preparation product is obtained.

[0066] Formulation Example 15:

[0067] 10 g of dinotefuran, 20 g of cyantraniliprole, 3 g of dodecyl sulfonate, 6 g of sodium lignosulfonate, 8 g of soy protein isolate, 20 g of sucrose, 6 g of decaglycerol, 4 g of quaternary ammonium salt of chitosan, 5 g of sodium carboxymethyl cellulose, 5 g of xanthan gum, and 13 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·cyantraniliprole concentrated preparation product.

[0068] Formulation Example 16:

[0069] 20 g of dinotefuran, 10 g of cyantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·cyantraniliprole concentrated preparation product.

[0070] Formulation Example 17:

[0071] 20 g of dinotefuran, 10 g of chlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·chlorantraniliprole concentrated preparation product.

[0072] Formulation Example 18:

[0073] 20 g of sulfoxaflor, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% sulfoxaflor·broflanilide concentrated preparation product.

[0074] Formulation Example 19:

[0075] 15 g of sulfoxaflor, 20 g of chlorfenapyr, 4 g of alkylnaphthalene sulfonate, 5 g of calcium lignosulfonate, 8 g of soy protein isolate, 24 g of sucrose, 6 g of decaglycerol, 4 g of quaternary ammonium salt of chitosan, 3 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 7 g of white carbon black are subjected to air flow pulverization to obtain a 35% sulfoxaflor·chlorfenapyr concentrated preparation product.

[0076] Formulation Example 20:

[0077] 20 g of sulfoxaflor, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·chlorfenapyr concentrated preparation product.

[0078] Formulation Example 21:

[0079] 20 g of sulfoxaflor, 10 g of flupyradifurone, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·flupyradifurone concentrated preparation product.

[0080] Formulation Example 22:

[0081] 20 g of sulfoxaflor, 10 g of chlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·chlorantraniliprole concentrated preparation product.

[0082] Comparative Example 1:

[0083] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 35 g of sucrose, 5 g of decaglycerol, 5 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0084] Comparative Example 2:

[0085] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 10 g of quaternary ammonium salt of chitosan, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0086] Comparative Example 3:

[0087] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, 10 g of kaolin, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0088] Comparative Example 4:

[0089] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 8 g of xanthan gum, 10 g of kaolin, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0090] Comparative Example 5:

[0091] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 18 g of kaolin, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0092] Comparative Example 6:

[0093] 20 g of clothianidin, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% clothianidin·broflanilide concentrated preparation product.

[0094] Comparative Example 7:

[0095] 30 g of beta-cypermethrin, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 10 g of soy protein isolate, 25 g of sucrose, 5 g of decaglycerol, 5 g of chitosan quaternary ammonium salt, 4 g of sodium carboxymethyl cellulose, 4 g of xanthan gum, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% beta-cypermethrin concentrated preparation product.

[0096] Comparative Example 8:

[0097] 20 g of clothianidin, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air-flow pulverization to obtain a 30% clothianidin·chlorfenapyr concentrated preparation product.

[0098] Comparative Example 9:

[0099] 20 g of clothianidin, 10 g of flubendiamide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% clothianidin·flubendiamide concentrated preparation product.

[0100] Comparative Example 10:

[0101] 20 g of clothianidin, 10 g of tetrachlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% clothianidin·tetrachlorantraniliprole concentrated preparation product.

[0102] Comparative Example 11:

[0103] 20 g of dinotefuran, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·broflanilide concentrated preparation product.

[0104] Comparative Example 12:

[0105] 20 g of dinotefuran, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·chlorfenapyr concentrated preparation product.

[0106] Comparative Example 13:

[0107] 20 g of dinotefuran, 10 g of flubendiamide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·flubendiamide concentrated preparation product.

[0108] Comparative Example 14(:

[0109] 20 g of dinotefuran, 10 g of tetrachlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of white carbon black are subjected to air flow pulverization to obtain a 30% dinotefuran·tetrachlorantraniliprole concentrated preparation product.

[0110] Comparative Example 15:

[0111] 20 g of sulfoxaflor, 10 g of broflanilide, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·broflanilide concentrated preparation product.

[0112] Comparative Example 16:

[0113] 20 g of sulfoxaflor, 10 g of chlorfenapyr, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·chlorfenapyr concentrated preparation product.

[0114] Comparative Example 17:

[0115] 20 g of sulfoxaflor, 10 g of flupyradifurone, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·flupyradifurone concentrated preparation product.

[0116] Comparative Example 18:

[0117] 20 g of sulfoxaflor, 10 g of tetrachlorantraniliprole, 3 g of dodecyl sulfonate, 6 g of naphthalene sulfonate formaldehyde condensate (morwet D-425), 53 g of kaolin, and 8 g of silica white are subjected to air flow pulverization to obtain a 30% sulfoxaflor·tetrachlorantraniliprole concentrated preparation product.

[0118] II. Application Examples

[0119] Application Example 1: Indoor efficacy test for controlling houseflies (spray test)

[0120] Test method: Refer to GB / T13919.1-2009 Indoor Efficacy Test and Evaluation of Hygienic Insecticides for Pesticide Registration, spray test.

[0121] Experimental treatment: The formulation examples 1-8 and comparative examples 1-6 are all diluted 1000 times with water and used at a dosage of 25 mg / ㎡ of the formulation.

[0122] Test targets: Susceptible houseflies (reared indoors), resistant houseflies (collected from farms using pesticides all year round).

[0123] The test results are as follows:

[0124] Table - 1 Indoor Efficacy Test Results of Houseflies (Spray Method / Susceptible)

[0125]

[0126] The above results show that in the spray experiment, the quick-acting property and lethal performance have been significantly improved after adding feeding stimulants, especially compound feeding stimulants, while the high molecular humectant and high molecular thickener have no significant effect on the quick-acting property and lethal performance during the spray experiment.

[0127] Table - 2 Indoor efficacy test results of houseflies (spray method / sensitive)

[0128]

[0129]

[0130] The above results show that when the ratio of clothianidin and broflanilide is 2:1 - 3:1, it has the best quick-acting property and lethality.

[0131] Table - 3 Indoor efficacy test results of houseflies (spray method / resistant)

[0132]

[0133] The above test results show that the 30% clothianidin·broflanilide concentrated preparation product still has excellent quick-acting property and lethal performance against resistant houseflies, and the effect is significantly better than that of the 30% beta-cypermethrin concentrated preparation product, and it is very suitable for the control of resistant pests.

[0134] Application Example 2: Indoor efficacy test for controlling houseflies (residual spraying)

[0135] Test method: Residual spraying test. According to the residual spraying test in GBT 13917.1 - 2009 Pesticide registration - Indoor efficacy test and evaluation of hygienic insecticides - Part 1: Aerosols, the knockdown time KT 50 and mortality rate were determined 30 days after coating on the absorption surface.

[0136] Experimental treatment: Dilute the preparation of Example 1 and the preparations of Comparative Examples 1 - 6 with water by 500 times, coat the white ash board according to the preparation dosage of 100 mg / ㎡, and determine the knockdown time KT 50 and mortality rate 30 days after coating.

[0137] Table - 4 Indoor efficacy test results of houseflies (residual spraying / sensitive)

[0138]

[0139]

[0140] The above test results show that after the 30% clothianidin·broflanilide concentrated preparation product is compounded with an optimized feeding promoter, a high-molecular humectant, and a high-molecular thickener, the long-term sustained effect is significantly improved by increasing the surface retention amount, surface moisture retention, and surface palatability of the active ingredients. Changing any one of the auxiliary components will have a relatively obvious impact on the effect. The compounded products of other component A and component B also have a similar long-term sustained effect after being paired with an optimized feeding promoter, a high-molecular humectant, and a high-molecular thickener.

[0141] A concentrated composition for controlling sanitary pests, its preparation method and application of the present invention have been described through specific examples. Those skilled in the art can draw on the content of the present invention and appropriately change links such as raw materials, process conditions, compound combinations or ratios of active ingredients to achieve corresponding other purposes. All relevant changes do not depart from the content of the present invention. All similar substitutions and modifications are obvious to those skilled in the art and are considered to be included within the scope of the present invention.

[0142] In the description of this specification, the description with reference to terms such as "a specific embodiment", "some embodiments", "examples", "specific examples", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0143] The protection scope of the present application is not limited to the above embodiments. Obviously, those skilled in the art can make various changes and deformations to the present application without departing from the scope and spirit of the present invention. If these changes and deformations fall within the scope of the claims of the present application and their equivalent technologies, the intention of the present application also includes these changes and deformations.

Claims

1. A concentrated composition for controlling sanitary pests, characterized in that, The components and their mass percentages are as follows: The mass ratio of the active component A to the active component B is 1:9 - 9:1; The active component A is selected from one or more of clothianidin, dinotefuran, and sulfoxaflor; The active component B is selected from one or more of chlorfenapyr, broflanilide, flubendiamide, and tetrachlorantraniliprole; The feeding promoter is selected from the compounding of protein components and sugar components; The high molecular weight humectant is selected from one or more of polyethylene glycol, polyglycerol, chitin hydrochloride, chitosan quaternary ammonium salt, and hyaluronic acid; The high molecular weight thickener is selected from one or more of sodium carboxymethyl cellulose, sodium carboxymethyl starch, xanthan gum, locust bean gum, and konjac gum; 2. The concentrated composition for controlling sanitary pests according to claim 1, wherein The mass percentages of the active component A and the active component B are 20 - 40%; preferably 30%.

3. The concentrated composition for controlling sanitary pests according to claim 1 or 2, characterized in that, The active component A is clothianidin and the active component B is broflanilide.

4. The concentrated composition for controlling sanitary pests according to claim 3, wherein, The mass ratio of the active component A to the active component B is 1:1 - 5:1, preferably 2:1 - 3:

1.

5. The concentrated composition for controlling sanitary pests according to claim 1, characterized in that The mass percentage of the feeding promoter is 20 - 35%; preferably 35%.

6. The concentrated composition for controlling sanitary pests according to claim 1 or 5, characterized in that, The feeding promoter is selected from the compounding of protein components such as soy protein isolate, yeast extract, tryptone, or beef peptone, and sugar components such as glucose, fructose, lactose, sucrose, or maltose. Preferably, it is the compounding of protein components soy protein isolate, yeast extract, and sugar components glucose, sucrose. More preferably, it is the compounding of soy protein isolate and sucrose.

7. The concentrated composition for controlling sanitary pests according to claim 6, characterized in that, The mass ratio of the protein component to the sugar component in the feeding promoter is 1:1 - 1:3, preferably 2:

5.

8. The concentrated composition for controlling sanitary pests according to claim 1, characterized in that, The mass percentage of the high molecular weight humectant is 8 - 10%; preferably 10%.

9. The concentrated composition for controlling sanitary pests according to claim 1 or 8, characterized in that, The high molecular weight humectant is a compounding of polyglycerol and chitosan quaternary ammonium salt.

10. The concentrated composition for controlling sanitary pests according to claim 9, wherein The mass ratio of polyglycerol to chitosan quaternary ammonium salt is 2:1 - 1:2, preferably 1:

1.

11. The concentrated composition for controlling sanitary pests according to claim 1, characterized in that, The mass percentage of the high molecular weight thickener is 8 - 10%; preferably 8%.

12. The concentrated composition for controlling sanitary pests according to claim 1 or 11, characterized in that, The high molecular weight thickener is a compounding of sodium carboxymethyl cellulose and xanthan gum.

13. The concentrated composition for controlling sanitary pests according to claim 12, characterized in that, The mass ratio of sodium carboxymethyl cellulose to xanthan gum is 2:1 - 1:2, preferably 1:

1.

14. The concentrated composition for controlling sanitary pests according to claim 1, characterized in that, The other excipients are selected from surfactants and fillers, and optionally acid-base regulators and defoamers.

15. The concentrated composition for controlling sanitary pests according to claim 14, characterized in that, The mass fraction of the surfactant is 5 - 15%, preferably 9 - 10%.

16. The concentrated composition for controlling sanitary pests according to claim 14 or 15, characterized in that, The surfactant is alkylbenzene sulfonate and naphthalene sulfonate formaldehyde condensate.

17. The concentrated composition for controlling sanitary pests according to claim 16, wherein, The mass ratio of alkylbenzene sulfonate to naphthalene sulfonate formaldehyde condensate is 1:1 - 1:

2.

18. The concentrated composition for controlling sanitary pests according to claim 1, wherein The concentrated composition is a powder.

19. Use of the concentrated composition for controlling hygienic pests according to any one of claims 1-18, characterized in that, For controlling sanitary pests, the sanitary pests are preferably mosquitoes, flies, cockroaches, termites, ants, fleas, bedbugs, especially resistant mosquitoes and flies.

20. The use according to claim 19, characterized in that, The concentrated composition for controlling sanitary pests controls sanitary pests by spraying or residual spraying; preferably, the concentrated composition for controlling sanitary pests is diluted with water before use.

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