Processing method of granules for treating common cold due to wind-cold

Abstract

The invention discloses a processing method of granules for treating common cold due to wind-cold. The processing method comprises the following steps: step 1, obtaining an ingredient A and an ingredient B according to a weight ratio; 2, soaking the ingredient A and extracting volatile oil to obtain the volatile oil and medicine residues; 3, combining the medicine residues with the ingredient B, and decocting to obtain extract; 4, adding the volatile oil into the extract to obtain a mixed solution; step five, adding the mixed solution, cane sugar and dextrin into granulation equipment according to a weight ratio for granulation, and then drying and uniformly mixing to obtain finished product granules; step 6, sub-packaging, boxing and boxing the finished product particles according to required specifications; clathrating the volatile oil in the step 4 with beta-cyclodextrin to prepare a volatile oil clathrate liquid, and then adding the volatile oil clathrate liquid into the extract; according to the invention, the treatment and addition mode of the volatile oil is changed, and later direct injection and mixing with granular medicines are changed into inclusion with beta-cyclodextrin, then extract is added, and granulation is carried out, so that the smell of the volatile oil is effectively covered, administration of patients is facilitated, and the stability of the volatile oil can be ensured.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical preparation, and particularly relates to a processing method for wind-cold cold granules. Background Art

[0002] Wind-cold cold granules are mainly used for the treatment of symptoms such as wind-cold cold, fever, headache, aversion to cold, no sweating, cough, nasal congestion, and runny nose with clear discharge. In the existing processing methods for wind-cold cold granules, the volatile oil of the medicine is often mixed into the medicine granules by a direct spraying method during the pre-preparation. Although the production is simple, there are disadvantages such as a strong odor in the finished product, poor palatability for patients, and difficulty in maintaining the properties of the volatile oil, and there is a certain room for improvement. Summary of the Invention

[0003] Aiming at the problems existing in the background art, the purpose of the present invention is to provide a processing method for wind-cold cold granules, which effectively solves the problems existing in the background art.

[0004] To achieve the above purpose, the present invention adopts the following technical solutions:

[0005] The processing method for wind-cold cold granules includes the following steps:

[0006] Step 1: Weigh and mix some types of raw materials according to the weight ratio to obtain ingredient A, and mix the remaining types of raw materials to obtain ingredient B;

[0007] Step 2: Soak and extract the volatile oil from the ingredient A to obtain the volatile oil and medicinal residues;

[0008] Step 3: Combine the medicinal residues with ingredient B to decoct the liquid, then filter, concentrate, and collect the extract to obtain the extract paste;

[0009] Step 4: Add the volatile oil to the extract paste to obtain a mixed liquid;

[0010] Step 5: Add the mixed liquid, sucrose, and dextrin to the granulating equipment according to the weight ratio for granulation. The granulation method adopts spray granulation, and then the finished product granules are obtained through the drying and mixing processes;

[0011] Step 6: Sub-pack, box, and case the finished product granules according to the required specifications;

[0012] The volatile oil in Step 4 is prepared into a volatile oil inclusion complex solution by β-cyclodextrin inclusion and then added to the extract paste.

[0013] Further, the preparation method of the volatile oil inclusion liquid is as follows: Dilute the volatile oil with anhydrous ethanol with a volume 1-2 times that of the volatile oil to obtain a volatile oil dilution. Then, dissolve beta-cyclodextrin in pure water with a weight 8-12.5 times that of beta-cyclodextrin by heating and stirring to obtain a beta-cyclodextrin dilution and cool it. After cooling the beta-cyclodextrin dilution, place it on an inclusion device and keep it at a constant temperature, and slowly add the volatile oil dilution. After the addition is completed, continue to stir and include at a constant temperature to obtain the volatile oil inclusion liquid.

[0014] Further, the ingredient A includes Saposhnikovia divaricata, Perilla frutescens leaves, and Angelica dahurica; the ingredient B includes Ephedra sinica, Pueraria lobata, Cinnamomum cassia, Platycodon grandiflorum, Armeniaca vulgaris var. ansu, Citrus reticulata Blanco, Zingiber officinale Rosc., and Glycyrrhiza uralensis Fisch.

[0015] Further, in step two, ingredient A is soaked in pure water with a weight 6-10 times that of ingredient A for 0.3-0.7 h and then distilled for 3-7 h to extract the volatile oil.

[0016] Further, in step three, the medicinal residues and ingredient B are decocted three times with pure water with a weight 8-12 times that of the medicinal residues and ingredient B, and the decoction time for the three times decreases.

[0017] Further, in step three, the relative density of the extract is 1.20-1.25, and the temperature is 55-60 °C.

[0018] The present invention has the following beneficial technical effects:

[0019] The present invention changes the addition method of the volatile oil treatment. It is changed from directly spraying it into the mixture with the granular medicine in the later stage to adding it to the extract after being included by beta-cyclodextrin and then granulating. In this way, it not only effectively masks the smell of the volatile oil, which is beneficial for patients to take, but also can ensure the stability of the volatile oil; while having the above advantages, the efficacy of the finished product of the wind-cold cold granules will not be affected. Description of the Drawings

[0020] Figure 1 It is a process schematic diagram of an embodiment of the present invention; Detailed Embodiments

[0021] The following further describes in detail the embodiments of the present invention in conjunction with the drawings. The following embodiments are used to illustrate the present invention, but cannot be used to limit the scope of the present invention.

[0022] In the description of the present invention, unless otherwise specified, "a plurality of" means two or more; the orientation or positional relationship indicated by terms such as "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation on the present invention. In the description of the present invention, it should be noted that unless otherwise clearly specified and defined, the terms "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0023] Example 1

[0024] As Figure 1 shown, the processing method of the wind-cold cold granules described in this embodiment includes the following steps:

[0025] Step 1: Weigh some types of raw materials according to the weight ratio and mix them to obtain ingredient A, and mix the remaining types of raw materials to obtain ingredient B. Specifically, ingredient A includes 1.5 parts by weight of Saposhnikovia divaricata, 1.5 parts by weight of Perilla frutescens leaves, and 1 part by weight of Angelica dahurica; ingredient B includes 1 part by weight of Ephedra sinica, 1.5 parts by weight of Pueraria lobata, 1 part by weight of Cinnamomum cassia, 1 part by weight of Platycodon grandiflorum, 1.5 parts by weight of Prunus armeniaca var. ansu, 1 part by weight of Citrus reticulata Blanco, 1 part by weight of Zingiber officinale Rosc., and 1 part by weight of Glycyrrhiza uralensis Fisch.

[0026] Step 2: Soak ingredient A and extract volatile oil to obtain volatile oil and medicinal residues. Specifically, ingredient A is soaked in 6 times the weight of pure water for 0.3 h and then distilled for 3 h to extract volatile oil;

[0027] Step 3: Combine the medicinal residues with ingredient B, decoct the liquid, filter, concentrate, and collect the extract to obtain an extract. Specifically, the medicinal residues and ingredient B are added to 8 times the weight of pure water and decocted three times, and the decoction time for the three times decreases. The first time is 3 h, the second time is 2 h, and the third time is 1 h; finally, the relative density of the obtained extract is controlled at 1.20 - 1.25, and the temperature is controlled at 55 - 60 °C.

[0028] Step 4: Add the volatile oil to the extract to obtain a mixed liquid;

[0029] Step 5: Add the mixed liquid, sucrose, and dextrin according to the weight ratio to a granulation device for granulation. The granulation method uses spray granulation, and then through drying and mixing processes, finished granules are obtained;

[0030] Step Six: Subpackage the finished granules according to the required specifications, pack them into boxes, and then into cases;

[0031] The volatile oil in Step Four is included by beta-cyclodextrin to obtain a volatile oil inclusion liquid and then added to the extract. The specific method is as follows: Dilute the volatile oil with anhydrous ethanol with a volume of 1 time to obtain a volatile oil dilution liquid. Then, dissolve beta-cyclodextrin with pure water with a weight of 8 times by heating and stirring to obtain a beta-cyclodextrin dilution liquid. The heating temperature is 60°C. After cooling the beta-cyclodextrin dilution liquid to 50°C, place it on the inclusion equipment to keep it at a constant temperature and slowly add the volatile oil dilution liquid. After the addition is completed, continue to stir and include at a constant temperature for 4 hours to obtain the volatile oil inclusion liquid; the above inclusion equipment is an electric heating stirring heat preservation tank.

[0032] This embodiment changes the addition method of the volatile oil treatment. Compared with the prior art, the volatile oil is changed from direct spraying in the later stage to being added after being included by beta-cyclodextrin. This not only effectively masks the smell of the volatile oil, is beneficial to the patient's taking, but also improves the stability of the volatile oil; while having the above advantages, the efficacy of the finished cold granules for wind-cold type will not be affected.

[0033] Example Two

[0034] The processing method of the cold granules for wind-cold type in this embodiment includes the following steps:

[0035] Step One: Weigh and mix some types of raw materials according to the weight ratio to obtain ingredient A, and mix the remaining types of raw materials to obtain ingredient B. Specifically, ingredient A includes 1.5 parts by weight of Saposhnikovia divaricata, 1.5 parts by weight of Perilla leaf, and 1 part by weight of Angelica dahurica; ingredient B includes 1 part by weight of Ephedra sinica, 1.5 parts by weight of Pueraria lobata, 1 part by weight of Cinnamomum cassia, 1 part by weight of Platycodon grandiflorum, 1.5 parts by weight of Prunus armeniaca var. ansu, 1 part by weight of Citrus reticulata Blanco, 1 part by weight of Zingiber officinale Rosc., and 1 part by weight of Glycyrrhiza uralensis Fisch.

[0036] Step Two: Soak and extract the volatile oil from ingredient A to obtain the volatile oil and medicinal residues. Specifically, ingredient A is soaked in pure water with a weight of 8 times for 0.5 hours and then distilled for 5 hours to extract the volatile oil;

[0037] Step Three: Combine the medicinal residues with ingredient B to decoct the liquid, then filter, concentrate, and collect the extract. Specifically, the medicinal residues and ingredient B are added to pure water with a weight of 10 times and decocted three times. The decoction time for the three times decreases. The first time is 3 hours, the second time is 2 hours, and the third time is 1 hour; finally, the relative density of the obtained extract is controlled at 1.20 - 1.25, and the temperature is controlled at 55 - 60°C.

[0038] Step Four: Add the volatile oil to the extract to obtain a mixed liquid;

[0039] Step Five: Add the mixed liquid, sucrose, and dextrin according to the weight ratio to the granulating equipment for granulation. The granulation method uses spray granulation, and then obtain the finished granules through the drying and mixing processes;

[0040] Step Six: Sub-pack the finished granules according to the required specifications, pack them into boxes, and then into cases;

[0041] The volatile oil in Step Four is included by beta-cyclodextrin to obtain a volatile oil inclusion liquid, which is then added to the extract. The specific method is as follows: Dilute the volatile oil with 1.5 times its volume of absolute ethanol to obtain a volatile oil dilution. Then, dissolve beta-cyclodextrin by heating and stirring with 10 times its weight of pure water to obtain a beta-cyclodextrin dilution. The heating temperature is 60°C. After cooling the beta-cyclodextrin dilution to 50°C, place it on an inclusion device and keep it at a constant temperature, and slowly add the volatile oil dilution. After the addition is completed, continue to stir and include at a constant temperature for 4 hours to obtain the volatile oil inclusion liquid; the above inclusion device is an electrically heated stirring and heat-preserving tank.

[0042] Example Three

[0043] The processing method of the wind-cold cold granules described in this example includes the following steps:

[0044] Step One: Weigh and mix some types of raw materials according to the weight ratio to obtain ingredient A, and mix the remaining types of raw materials to obtain ingredient B. Specifically, ingredient A includes 1.5 parts by weight of Saposhnikovia divaricata, 1.5 parts by weight of Perilla frutescens leaves, and 1 part by weight of Angelica dahurica; ingredient B includes 1 part by weight of Ephedra sinica, 1.5 parts by weight of Pueraria lobata, 1 part by weight of Cinnamomum cassia, 1 part by weight of Platycodon grandiflorum, 1.5 parts by weight of Prunus armeniaca var. ansu, 1 part by weight of Citrus reticulata Blanco, 1 part by weight of Zingiber officinale Rosc., and 1 part by weight of Glycyrrhiza uralensis Fisch.

[0045] Step Two: Soak and extract the volatile oil from ingredient A to obtain the volatile oil and medicinal residues. Specifically, ingredient A is soaked in 10 times its weight of pure water for 0.7 hours and then distilled for 7 hours to extract the volatile oil;

[0046] Step Three: Combine the medicinal residues with ingredient B to decoct the liquid, then filter, concentrate, and collect the extract. Specifically, the medicinal residues and ingredient B are added with 12 times their weight of pure water and decocted three times. The decoction time for the three times decreases. The first time is 3 hours, the second time is 2 hours, and the third time is 1 hour; finally, the relative density of the obtained extract is controlled at 1.20 - 1.25, and the temperature is controlled at 55 - 60°C.

[0047] Step Four: Add the volatile oil to the extract to obtain a mixed liquid;

[0048] Step Five: Add the mixed liquid, sucrose, and dextrin according to the weight ratio to a granulating device for granulation. The granulation method uses spray granulation, and then obtain the finished granules through the drying and mixing processes;

[0049] Step Six: Sub-pack the finished granules according to the required specifications, pack them into boxes, and then into cases;

[0050] The volatile oil in Step 4 is prepared into a volatile oil inclusion liquid by β-cyclodextrin inclusion and then added to the extract. The specific method is as follows: The volatile oil is diluted with 2 volumes of absolute ethanol to obtain a volatile oil dilution, and then β-cyclodextrin is dissolved by heating and stirring with 12.5 times its weight of pure water to obtain a β-cyclodextrin dilution. The heating temperature is 60 °C. After cooling the β-cyclodextrin dilution to 50 °C, it is placed on an inclusion device for constant temperature and the volatile oil dilution is slowly added. After the addition is completed, continue to stir and include at a constant temperature for 4 h to obtain the volatile oil inclusion liquid; the above inclusion device is an electric heating stirring insulation tank.

[0051] The embodiments of the present invention are given for purposes of illustration and description, and are not intended to be exhaustive or to limit the invention to the disclosed form. Many modifications and variations are obvious to those of ordinary skill in the art. The embodiments are chosen and described in order to best explain the principles of the invention and its practical application, and to enable those of ordinary skill in the art to understand the invention and design various embodiments with various modifications suitable for a particular purpose.

Claims

1. A method for processing cold granules, characterized in that: The following steps are involved: Step 1: Weigh some types of raw materials according to the weight ratio and mix them to obtain ingredient A, and mix the remaining types of raw materials to obtain ingredient B; Step 2: soaking the ingredient A and extracting volatile oil to obtain volatile oil and medicinal residues; Step 3: combining the medicinal residue with ingredient B to make a decoction, filtering and concentrating the mixture to obtain an extract; Step 4: adding the volatile oil to the extract to obtain a mixed solution; Step 5: adding the mixed solution, sucrose and dextrin according to the weight ratio into a granulation device for granulation, and then drying and mixing to obtain finished granules; Step 6: Pack the finished particles into packages, boxes and cartons according to the required specifications; The volatile oil in step 4 is included in beta-cyclodextrin to obtain a volatile oil inclusion liquid, which is then added to the extract.

2. The method for processing cold granules according to claim 1, characterized in that: The method for preparing the volatile oil inclusion liquid is as follows: diluting the volatile oil with 1-2 times the volume of anhydrous ethanol to obtain the volatile oil dilution liquid, then heating and stirring beta-cyclodextrin with 8-12.5 times the weight of pure water to dissolve the beta-cyclodextrin to obtain the beta-cyclodextrin dilution liquid and cooling it, placing the beta-cyclodextrin dilution liquid on an inclusion device for constant temperature after cooling and slowly adding the volatile oil dilution liquid, and continuing to stir and include at a constant temperature after the addition is completed to obtain the volatile oil inclusion liquid.

3. The method for processing cold granules according to claim 1, characterized in that: The ingredient A comprises fangfeng, perilla leaf and angelica dahurica; the ingredient B comprises ephedra, kudzu root, cassia twig, platycodon grandiflorum, bitter almond, tangerine peel, dried ginger and liquorice.

4. The method for processing cold granules according to claim 1, characterized in that: In the step 2, ingredient A is soaked in 6-10 times the weight of pure water for 0.3-0.7 hours and then distilled for 3-7 hours to extract volatile oil.

5. The method for processing cold granules according to claim 1, characterized in that: In the step 3, the Chinese medicinal residue and ingredient B are added with 8-12 times the weight of pure water and decocted three times, with the decocting time decreasing gradually.

6. The method for processing cold granules according to claim 5, characterized in that: The relative density of the extract in step 3 is 1.20-1.25, and the temperature is 55-60°C.

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