Anti-hair loss composition, preparation method thereof and anti-hair loss product

Abstract

The invention provides an anti-hair loss composition, a preparation method thereof and an anti-hair loss product. The composition is prepared from the following components in parts by mass: 8 to 25 parts of cacumen biotae extract, 0.1 to 10 parts of radix polygoni multiflori extract, 0.1 to 3 parts of flos carthami extract, 0.1 to 3 parts of fructus ligustri lucidi extract, 0.1 to 3 parts of cordyceps sinensis extract, 0.1 to 3 parts of ganoderma atrum extract, 0.1 to 3 parts of rhizoma chuanxiong extract, 0.1 to 2 parts of radix angelicae sinensis extract, 0.1 to 1 part of radix ginseng extract and 5 to 8 parts of fructus rosae roxburghii extract. The traditional Chinese medicine composition comprises the following components in parts by weight: 2-8 parts of a purslane extract, 6-12 parts of an oriental cherry flower extract, 0.01-1 part of ginsenoside, 1-3 parts of a bifidus yeast fermentation filtrate and 4-12 parts of recombinant III-type collagen. The composition can enable hair follicles to keep a good metabolic environment, and when the composition is applied to head hair follicle care products such as shampoo, hair conditioners and hair masks, the products can have a good anti-hair loss effect.

Description

Technical Field

[0001] The present invention relates to the technical field of anti - hair loss, and in particular to an anti - hair loss composition, a preparation method thereof, and an anti - hair loss product. Background Art

[0002] With the acceleration of the modern life rhythm, the increase of pressure, and the influence of environmental pollution and other factors, the problem of hair loss has become increasingly common, plaguing a large number of people. Hair loss not only affects personal image but also may bring psychological pressure to patients and reduce the quality of life. There are many existing anti - hair loss products on the market, but most of them have unsatisfactory effects and are difficult to fundamentally solve the problem of hair follicle health, unable to meet the urgent needs of consumers for effective anti - hair loss solutions.

[0003] Therefore, it is necessary to provide a product with good anti - hair loss effect. Summary of the Invention

[0004] Based on the above problems, the present invention provides an anti - hair loss composition. This composition can keep the hair follicles in a good metabolic environment. When this composition is used in hair follicle care products for the head such as shampoo, hair conditioner, and hair mask, it can endow these products with good anti - hair loss effects.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] An anti - hair loss composition, comprising the following components in parts by weight: 8 - 25 parts of Platycladus orientalis leaf extract, 0.1 - 10 parts of Polygonum multiflorum root extract, 0.1 - 3 parts of Carthamus tinctorius flower extract, 0.1 - 3 parts of Ligustrum lucidum fruit extract, 0.1 - 3 parts of Cordyceps sinensis extract, 0.1 - 3 parts of Ganoderma atrum extract, 0.1 - 3 parts of Ligusticum chuanxiong root extract, 0.1 - 2 parts of Angelica sinensis root extract, 0.1 - 1 part of Panax ginseng root extract, 5 - 8 parts of Rosa roxburghii fruit extract, 2 - 8 parts of Portulaca oleracea extract, 6 - 12 parts of Cerasus serrulata var. lannesiana extract, 0.01 - 1 part of ginsenoside, 1 - 3 parts of bifidobacterium ferment filtrate, 4 - 12 parts of recombinant type III collagen.

[0007] Optionally, the anti - hair loss composition comprises the following components in parts by weight: 10 - 20 parts of Platycladus orientalis leaf extract, 2 - 8 parts of Polygonum multiflorum root extract, 0.5 - 2 parts of Carthamus tinctorius flower extract, 0.5 - 2 parts of Ligustrum lucidum fruit extract, 0.5 - 2 parts of Cordyceps sinensis extract, 0.5 - 2 parts of Ganoderma atrum extract, 0.5 - 2 parts of Ligusticum chuanxiong root extract, 0.5 - 1.5 parts of Angelica sinensis root extract, 0.2 - 0.8 part of Panax ginseng root extract, 6 - 7 parts of Rosa roxburghii fruit extract, 3 - 6 parts of Portulaca oleracea extract, 8 - 10 parts of Cerasus serrulata var. lannesiana extract, 0.05 - 0.5 part of ginsenoside, 1.5 - 2.5 parts of bifidobacterium ferment filtrate, 5 - 10 parts of recombinant type III collagen.

[0008] Optionally, the anti - hair - loss composition comprises the following components in parts by weight: 15 parts of Platycladus orientalis leaf extract, 5 parts of Polygonum multiflorum root extract, 1.5 parts of Carthamus tinctorius flower extract, 1.5 parts of Ligustrum lucidum fruit extract, 1.5 parts of Cordyceps sinensis extract, 1.5 parts of Ganoderma atrum extract, 1.5 parts of Ligusticum chuanxiong root extract, 1 part of Angelica sinensis root extract, 0.5 part of Panax ginseng root extract, 6.5 parts of Rosa roxburghii fruit extract, 5 parts of Portulaca oleracea extract, 9 parts of Cerasus serrulata var. lannesiana extract, 0.1 part of ginsenoside, 2 parts of bifidobacterium ferment filtrate, and 8 parts of recombinant type III collagen.

[0009] A preparation method of the anti - hair - loss composition comprises the following steps:

[0010] Powderize the solid components in the composition respectively to obtain the corresponding powder components;

[0011] Mix the Cordyceps sinensis extract and Ganoderma atrum extract with a solvent and conduct the first stirring to obtain a suspension;

[0012] Sequentially add the Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Carthamus tinctorius flower extract, Ligustrum lucidum fruit extract, Ligusticum chuanxiong root extract, Angelica sinensis root extract, Panax ginseng root extract, Rosa roxburghii fruit extract, Portulaca oleracea extract, Cerasus serrulata var. lannesiana extract, ginsenoside, bifidobacterium ferment filtrate, and recombinant type III collagen into the suspension and conduct the second stirring to obtain a mixture;

[0013] Conduct desolvation treatment on the mixture to remove the solvent in the mixture and obtain a concentrated solution;

[0014] Conduct filtration treatment on the concentrated solution.

[0015] Optionally, the stirring speed of the first stirring is 800 - 1000 rpm; the stirring time of the first stirring is 15 - 20 min; the stirring speed of the second stirring is 500 - 600 rpm; the stirring time of the second stirring is 30 - 45 min.

[0016] Optionally, the particle size of the powder components obtained by the powderizing treatment is 80 - 100 mesh; the filtration treatment is carried out using a microporous filter membrane with a pore size of 0.22 - 0.45 μm.

[0017] Optionally, the solvent is anhydrous ethanol; the desolvation treatment is carried out by vacuum distillation, the temperature of the vacuum distillation is 40 - 50 °C, and the pressure of the vacuum distillation is 0.08 - 0.1 MPa.

[0018] An anti - hair - loss product comprises the anti - hair - loss composition.

[0019] Optionally, the mass percentage of the anti - hair - loss composition in the anti - hair - loss product is 5% - 20%.

[0020] Optionally, the anti - hair - loss product includes shampoo, hair conditioner or hair mask.

[0021] Beneficial effects

[0022] The anti - hair - loss composition of the present invention can maintain a good metabolic environment for hair follicles, promote the proliferation of hair follicle cells, reduce the production of scalp oil, and thus is beneficial to reducing the risk of hair loss through the synergistic cooperation of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Carthamus tinctorius flower extract, Ligustrum lucidum fruit extract, Cordyceps sinensis extract, Ganoderma atrum extract, Ligusticum chuanxiong root extract, Angelica sinensis root extract, Panax ginseng root extract, Rosa roxburghii fruit extract, Portulaca oleracea extract, Cerasus serrulata var. lannesiana extract, ginsenoside, bifidobacterium ferment filtrate, and recombinant type III collagen. When this composition is used in hair follicle care products for the head such as shampoo, hair conditioner, and hair mask, the product can have a good anti - hair - loss effect. Specific embodiments

[0023] An embodiment of the present invention provides an anti - hair - loss composition, which includes the following components in parts by weight: 8 - 25 parts of Platycladus orientalis leaf extract, 0.1 - 10 parts of Polygonum multiflorum root extract, 0.1 - 3 parts of Carthamus tinctorius flower extract, 0.1 - 3 parts of Ligustrum lucidum fruit extract, 0.1 - 3 parts of Cordyceps sinensis extract, 0.1 - 3 parts of Ganoderma atrum extract, 0.1 - 3 parts of Ligusticum chuanxiong root extract, 0.1 - 2 parts of Angelica sinensis root extract, 0.1 - 1 part of Panax ginseng root extract, 5 - 8 parts of Rosa roxburghii fruit extract, 2 - 8 parts of Portulaca oleracea extract, 6 - 12 parts of Cerasus serrulata var. lannesiana extract, 0.01 - 1 part of ginsenoside, 1 - 3 parts of bifidobacterium ferment filtrate, and 4 - 12 parts of recombinant type III collagen. In this embodiment, through the synergy of each component, a good metabolic environment for hair follicles can be maintained, the proliferation of hair follicle cells can be promoted, the production of scalp oil can be reduced, and thus it is beneficial to reducing the risk of hair loss.

[0024] Among them, Platycladus orientalis leaf extract: rich in various active ingredients such as flavonoids and terpenoids, can effectively dilate the scalp blood vessels, improve the blood circulation of hair follicles, ensure that hair follicle cells can obtain oxygen and nutrients in a timely and sufficient manner, and lay a solid foundation for anti - hair - loss.

[0025] Polygonum multiflorum root extract: can accurately act on hair follicle stem cells, regulate the endocrine signaling pathway, help the hair follicles smoothly transition from the resting phase to the growth phase, effectively stabilize hair growth, and reduce the probability of shedding.

[0026] Carthamus tinctorius flower extract: contains powerful blood - activating and stasis - removing ingredients such as safflower yellow pigment, can quickly eliminate the accumulation of blood stasis around hair follicles, reduce the inflammatory response, and return the micro - environment of hair follicles to a healthy state, further reducing the risk of hair loss.

[0027] Ligustrum lucidum fruit extract: Rich in antioxidants, it can efficiently scavenge free radicals in hair follicle cells, defend the integrity of cell membranes, resist the damage of oxidative stress to hair follicle cells, ensure the normal physiological functions of hair follicles are not disturbed, and further consolidate the anti - hair - loss effect of the composition.

[0028] Cordyceps sinensis extract: Containing a variety of rare nutritional components such as cordycepin and cordycep polysaccharide, it has excellent immune - regulating ability, can strengthen the local immune defense line of hair follicles, effectively resist the invasion of bacteria and fungi caused by low immunity, and prevent adverse conditions such as hair follicle infection and atrophy.

[0029] Ganoderma atrum extract: Abundant in active ingredients such as ganoderma polysaccharide and triterpenoids, it can deeply participate in the regulation of the signal transduction network of hair follicle cells, stimulate the potential of cell proliferation and differentiation, repair and reshape the damaged hair follicle structure, effectively stabilize the hair follicle environment, and avoid hair loss.

[0030] Ligusticum chuanxiong root extract: Relying on the unique combination of volatile oil and alkaloids, it exerts the effect of promoting blood circulation and qi movement, synergistically optimizes the qi and blood circulation of the scalp, and cooperates with other components to continuously transport nutrients to hair follicles, ensuring the smooth metabolism of hair follicles, keeping hair follicles in a healthy state, and reducing hair - loss problems.

[0031] Angelica sinensis root extract: As an important herb for enriching blood, the extract of its root can both enrich blood and promote blood circulation, accurately provide the necessary nutritional elements for the growth of hair follicles, promote the healthy growth of hair, and inject continuous power into the battle against hair loss.

[0032] Panax ginseng root extract: Overall, it can enhance the vitality of hair follicle cells, improve their efficiency of nutrient uptake and utilization, and also buffer the negative impact of external pressure on hair follicles, comprehensively protecting the health of hair follicles.

[0033] Rosa roxburghii fruit extract: With extremely high - content antioxidant components such as vitamin C and flavonoids, it penetrates deep into hair follicles, eliminates free radicals, reduces oxidative damage, and at the same time nourishes hair follicles with rich nutrients, providing a solid backing for the healthy growth of hair.

[0034] Portulaca oleracea extract: Possessing excellent antibacterial and anti - inflammatory abilities, it can accurately identify and inhibit the growth and reproduction of harmful bacteria on the scalp, quickly reduce hair follicle inflammation, create a clean environment for the growth of hair, and cooperate with other components to avoid hair loss.

[0035] Cerasus serrulata var. lannesiana extract: It can skillfully regulate the sebum secretion of the scalp, avoid the blockage of hair follicles caused by excessive sebum secretion, ensure that hair follicles can breathe freely and metabolize normally, promote the hair follicles to maintain a harmonious environment, and reduce the risk of hair loss.

[0036] Ginsenoside: Directly participates in regulating the proliferation and differentiation rhythm of hair follicle cells, optimizes the cell metabolism process, and promotes the growth and stability of hair.

[0037] Saccharomyces bisporus fermentation filtrate: Abundant in various vitamins, minerals, amino acids and other nutrients, it can deeply nourish hair follicles, activate the self-repair and regeneration potential of hair follicle cells, enhance the comprehensive ability of cells to cope with internal and external challenges, stabilize the hair follicle environment and prevent hair loss.

[0038] Recombinant type III collagen: Precisely supplement the collagen lost around hair follicles, reinforce the supporting structure of hair follicles, make hair follicles as stable as Mount Tai, and greatly reduce the risk of hair loss caused by loose and atrophied hair follicles.

[0039] Optionally, the anti-hair loss composition comprises the following components in parts by weight: 10-20 parts of Platycladus orientalis leaf extract, 2-8 parts of Polygonum multiflorum root extract, 0.5-2 parts of Carthamus tinctorius flower extract, 0.5-2 parts of Ligustrum lucidum fruit extract, 0.5-2 parts of Cordyceps sinensis extract, 0.5-2 parts of Ganoderma atrum extract, 0.5-2 parts of Ligusticum chuanxiong root extract, 0.5-1.5 parts of Angelica sinensis root extract, 0.2-0.8 parts of Panax ginseng root extract, 6-7 parts of Rosa roxburghii fruit extract, 3-6 parts of Portulaca oleracea extract, 8-10 parts of Cerasus serrulata var. lannesiana extract, 0.05-0.5 parts of ginsenoside, 1.5-2.5 parts of Saccharomyces bisporus fermentation filtrate, 5-10 parts of recombinant type III collagen.

[0040] Optionally, the anti-hair loss composition comprises the following components in parts by weight: 15 parts of Platycladus orientalis leaf extract, 5 parts of Polygonum multiflorum root extract, 1.5 parts of Carthamus tinctorius flower extract, 1.5 parts of Ligustrum lucidum fruit extract, 1.5 parts of Cordyceps sinensis extract, 1.5 parts of Ganoderma atrum extract, 1.5 parts of Ligusticum chuanxiong root extract, 1 part of Angelica sinensis root extract, 0.5 part of Panax ginseng root extract, 6.5 parts of Rosa roxburghii fruit extract, 5 parts of Portulaca oleracea extract, 9 parts of Cerasus serrulata var. lannesiana extract, 0.1 part of ginsenoside, 2 parts of Saccharomyces bisporus fermentation filtrate, 8 parts of recombinant type III collagen.

[0041] As some optional embodiments of the components in the composition, a brief description is given below.

[0042] In the composition, the parts by weight of Platycladus orientalis leaf extract can be 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, etc.

[0043] The parts by weight of Polygonum multiflorum root extract can be 0.1 part, 0.5 part, 1 part, 5 parts, 10 parts, etc.

[0044] The parts by weight of Carthamus tinctorius flower extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 part, 2 part, 2.5 part, 3 parts, etc.

[0045] The parts by weight of Ligustrum lucidum fruit extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 part, 2 part, 2.5 part, 3 parts, etc.

[0046] The parts by mass of the Cordyceps sinensis extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc.

[0047] The parts by mass of the Ganoderma atrum extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc.

[0048] The parts by mass of the Ligusticum chuanxiong root extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc.

[0049] The parts by mass of the Angelica sinensis root extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, 1.5 parts, 2 parts, etc.

[0050] The parts by mass of the Panax ginseng root extract can be 0.1 part, 0.3 part, 0.5 part, 0.8 part, 1 part, etc.

[0051] The parts by mass of the Rosa roxburghii fruit extract can be 5 parts, 5.3 parts, 5.5 parts, 6 parts, 6.3 parts, 6.5 parts, 7 parts, 7.3 parts, 7.5 parts, 8 parts, etc.

[0052] The parts by mass of the Portulaca oleracea extract can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, etc.

[0053] The parts by mass of the Cerasus serrulata var. lannesiana extract can be 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, etc.

[0054] The parts by mass of the ginsenoside can be 0.01 part, 0.03 part, 0.05 part, 0.08 part, 1 part, etc.

[0055] The parts by mass of the bifidobacterium ferment filtrate can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc.

[0056] The parts by mass of the recombinant type III collagen can be 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, etc.

[0057] It can be understood that the parts by mass of each component in the composition can also make other suitable selections within the range of the parts by mass listed in this article.

[0058] Another embodiment of the present invention provides a method for preparing the above composition, comprising the following steps: separately pulverizing the solid components in the components to obtain corresponding powder components; mixing the Cordyceps sinensis extract, Ganoderma atrum extract with a solvent and performing a first stirring to obtain a suspension; sequentially adding the Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Carthamus tinctorius flower extract, Ligustrum lucidum fruit extract, Ligusticum chuanxiong root extract, Angelica sinensis root extract, Panax ginseng root extract, Rosa roxburghii fruit extract, Portulaca oleracea extract, Cerasus serrulata var. lannesiana extract, ginsenoside, bifidobacterium ferment filtrate, recombinant type III collagen into the suspension and performing a second stirring to obtain a mixture; performing a desolvation treatment on the mixture to remove the solvent in the mixture to obtain a concentrate; and performing a filtration treatment on the concentrate. The method for preparing the composition in this embodiment is simple and easy to implement, does not rely on complex processes and expensive equipment, and is convenient for operation and popularization.

[0059] It can be understood that the extracts in the above components can be commercially available extracts. For example, they can be extracts obtained by solvent extraction. Optionally, the solvent can be anhydrous ethanol.

[0060] It can be understood that the bifidobacterium ferment filtrate can be a commercially available product, which is a metabolite, cytoplasmic fragment, cell wall component and polysaccharide complex obtained by culturing, inactivating and decomposing bifidobacterium.

[0061] Optionally, the stirring speed of the first stirring is 800 - 1000 rpm. For example, the stirring speed of the first stirring can be 800 rpm, 850 rpm, 900 rpm, 950 rpm, 1000 rpm, etc.

[0062] Optionally, the stirring time of the first stirring is 15 - 20 min. For example, the stirring time of the first stirring can be 15 min, 16 min, 17 min, 18 min, 19 min, 20 min, etc.

[0063] Optionally, the stirring speed of the second stirring is 500 - 600 rpm. For example, the stirring speed of the second stirring can be 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm, etc.

[0064] Optionally, the stirring time of the second stirring is 30 - 45 min. For example, the stirring time of the second stirring can be 30 min, 35 min, 40 min, 45 min, etc.

[0065] Optionally, the particle size of the powder components obtained by pulverizing is 80 - 100 mesh. The filtration treatment is performed using a microporous membrane with a pore size of 0.22 - 0.45 μm.

[0066] Optionally, the solvent is absolute ethanol; the solvent removal treatment is carried out by vacuum distillation, the temperature of the vacuum distillation is 40 - 50 °C, and the pressure of the vacuum distillation is 0.08 - 0.1 MPa.

[0067] Optionally, the temperature of the vacuum distillation is 40 °C, 42 °C, 45 °C, 48 °C, 50 °C, etc.

[0068] Optionally, the pressure of the vacuum distillation is 0.08 MPa, 0.09 MPa, 0.1 MPa, etc.

[0069] Another embodiment of the present invention provides an anti - hair - loss product. The anti - hair - loss product includes the above - mentioned anti - hair - loss composition.

[0070] Optionally, the mass percentage of the anti - hair - loss composition in the anti - hair - loss product is 5% - 20%. For example, the mass percentage of the anti - hair - loss composition in the anti - hair - loss product is 5%, 8%, 10%, 12%, 15%, 18%, 20%, etc.

[0071] Optionally, the anti - hair - loss product includes shampoo, hair conditioner or hair mask.

[0072] Example 1

[0073] In this example, the composition is composed of the following components: 15 parts of Platycladus orientalis leaf extract, 5 parts of Polygonum multiflorum root extract, 1.5 parts of Carthamus tinctorius flower extract, 1.5 parts of Ligustrum lucidum fruit extract, 1.5 parts of Cordyceps sinensis extract, 1.5 parts of Ganoderma atrum extract, 1.5 parts of Ligusticum chuanxiong root extract, 1 part of Angelica sinensis root extract, 0.5 part of Panax ginseng root extract, 6.5 parts of Rosa roxburghii fruit extract, 5 parts of Portulaca oleracea extract, 9 parts of Cerasus serrulata var. lannesiana extract, 0.1 part of ginsenoside, 2 parts of bifidobacterium ferment filtrate, and 8 parts of recombinant type III collagen.

[0074] In this example, the preparation method of the composition is as follows:

[0075] S101: The solid components in the components are respectively pulverized to obtain the corresponding powder components. The particle size of the powder components obtained by the pulverization treatment is 90 mesh.

[0076] S102: Mix the Cordyceps sinensis extract and Ganoderma atrum extract with the solvent and carry out the first stirring. The solvent is absolute ethanol to obtain a suspension. The stirring speed of the first stirring is 900 rpm, and the stirring time of the first stirring is 15 min.

[0077] S103: Add the extracts of Platycladus orientalis leaves, Polygonum multiflorum root, Carthamus tinctorius flower, Ligustrum lucidum fruit, Ligusticum chuanxiong root, Angelica sinensis root, Panax ginseng root, Rosa roxburghii fruit, Portulaca oleracea, Cerasus serrulata var. lannesiana, ginsenoside, bifidobacterium ferment filtrate, and recombinant type III collagen into the suspension in sequence, and perform the second stirring to obtain a mixed solution. The stirring speed of the second stirring is 550 rpm, and the stirring time of the second stirring is 40 min.

[0078] S104: Perform desolvation treatment on the mixed solution to remove the solvent in the mixed solution and obtain a concentrated solution. The desolvation treatment adopts vacuum distillation. The temperature of the vacuum distillation is 45 °C, and the pressure of the vacuum distillation is 0.08 MPa.

[0079] S105: Perform filtration treatment on the concentrated solution. The filtration treatment is performed using a microporous membrane with a pore size of 0.22 - 0.45 μm.

[0080] Examples 2 - 5, Comparative Examples 1 - 3

[0081] Compared with Example 1, the differences between Examples 2 - 5 and Comparative Examples 1 - 3 are that the mass parts of each component in the composition are different, as specifically shown in Table 1.

[0082] Test Example

[0083] (1) Hair follicle cell proliferation test: Isolate and culture dermal papilla cells of hair follicles from fresh human scalp tissue, select cells in the logarithmic growth phase with good condition, and inoculate them into a 96 - well plate at a density of 5×10 3 cells per well, and set 6 replicates. After the cells adhere, they are divided into different test groups. Different test groups correspond to each example and comparative example respectively. The mass percentage of the composition in each test group is 5% (this concentration can also simulate the mass percentage of the composition in anti - hair loss products). After culturing for 72 hours, add 20 μL of MTT solution (5 mg / mL) to each well and continue to incubate for 4 hours. Terminate the culture, carefully aspirate the culture medium in the wells, add 150 μL of DMSO to each well, and oscillate for 10 minutes to fully dissolve the crystals. Use an enzyme - linked immunosorbent assay (ELISA) reader to measure the absorbance value of each well at a wavelength of 570 nm to reflect the cell proliferation situation. The hair follicle cell proliferation rate = (n1 - n2) / n1×100%, where n1 represents the initial cell number and n2 represents the cell number after culture. The test results are shown in Table 1.

[0084] (2) Scalp sebum secretion test: Test subjects: 160 healthy people aged 30 - 60 years old, including 80 females and 80 males. They were randomly divided into 8 groups, with 10 females and 10 males in each group. The compositions of the examples and comparative examples were formulated into shampoos with a mass percentage of 5%. Each group of test subjects used the shampoos of different examples and comparative examples correspondingly. Shampoo usage frequency: 3 times a week for 4 consecutive weeks. After use, the scalp sebum content was tested. Calculate the sebum change rate. Sebum change rate = m2 / m1 × 100%, where m1 represents the scalp sebum content before using the shampoo, and m2 represents the scalp sebum content after using the shampoo. The sebum content is the average value of the scalp sebum content tested by the test subjects in each group. The test results are shown in Table 2.

[0085] Table 1

[0086]

[0087] Table 2

[0088] Hair follicle cell proliferation rate Rate of change in oil content Example 1 213.4％ 12.3％ Example 2 175.5％ 34.5％ Example 3 197.2％ 23.1％ Example 4 201.3％ 20.7％ Example 5 168.7％ 36.1％ Comparative Example 1 74.1％ 67.8％ Comparative Example 2 80.3％ 62.2％ Comparative Example 3 30.6％ 87.4％

[0089] As can be seen from Table 1 and Table 2, through the synergistic cooperation of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Carthamus tinctorius flower extract, Ligustrum lucidum fruit extract, Cordyceps sinensis extract, Ganoderma atrum extract, Ligusticum chuanxiong root extract, Angelica sinensis root extract, Panax ginseng root extract, Rosa roxburghii fruit extract, Portulaca oleracea extract, Cerasus serrulata var. lannesiana extract, ginsenoside, bifidobacterium ferment filtrate, and recombinant type III collagen, the proliferation rate of hair follicle cells can be effectively increased, the sebum content can be reduced, and thus the composition can have a better anti - hair loss effect.

[0090] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

[0091] For those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation to the present invention.

Claims

1. An anti - hair loss composition, characterized in that, Comprising the following components in parts by weight: 8-25 parts of Platycladus orientalis leaf extract, 0.1-10 parts of Polygonum multiflorum root extract, 0.1-3 parts of Carthamus tinctorius flower extract, 0.1-3 parts of Glossy privet fruit extract, 0.1-3 parts of Cordyceps sinensis extract, 0.1-3 parts of Ganoderma atrum extract, 0.1-3 parts of Ligusticum chuanxiong root extract, 0.1-2 parts of Angelica sinensis root extract, 0.1-1 part of Panax ginseng root extract, 5-8 parts of Rosa roxburghii fruit extract, 2-8 parts of Portulaca oleracea extract, 6-12 parts of Cerasus serrulata var. lannesiana extract, 0.01-1 part of ginsenoside, 1-3 parts of bifida yeast ferment filtrate, 4-12 parts of recombinant type III collagen.

2. The anti-hair loss composition according to claim 1, characterized in that, Comprising the following components in parts by weight: 10-20 parts of Platycladus orientalis leaf extract, 2-8 parts of Polygonum multiflorum root extract, 0.5-2 parts of Carthamus tinctorius flower extract, 0.5-2 parts of Glossy privet fruit extract, 0.5-2 parts of Cordyceps sinensis extract, 0.5-2 parts of Ganoderma atrum extract, 0.5-2 parts of Ligusticum chuanxiong root extract, 0.5-1.5 parts of Angelica sinensis root extract, 0.2-0.8 part of Panax ginseng root extract, 6-7 parts of Rosa roxburghii fruit extract, 3-6 parts of Portulaca oleracea extract, 8-10 parts of Cerasus serrulata var. lannesiana extract, 0.05-0.5 part of ginsenoside, 1.5-2.5 parts of bifida yeast ferment filtrate, 5-10 parts of recombinant type III collagen.

3. The anti - hair - loss composition according to claim 2, wherein, Comprising the following components in parts by weight: 15 parts of Platycladus orientalis leaf extract, 5 parts of Polygonum multiflorum root extract, 1.5 parts of Carthamus tinctorius flower extract, 1.5 parts of Glossy privet fruit extract, 1.5 parts of Cordyceps sinensis extract, 1.5 parts of Ganoderma atrum extract, 1.5 parts of Ligusticum chuanxiong root extract, 1 part of Angelica sinensis root extract, 0.5 part of Panax ginseng root extract, 6.5 parts of Rosa roxburghii fruit extract, 5 parts of Portulaca oleracea extract, 9 parts of Cerasus serrulata var. lannesiana extract, 0.1 part of ginsenoside, 2 parts of bifida yeast ferment filtrate, 8 parts of recombinant type III collagen.

4. The preparation method of the anti - hair - loss composition according to any one of claims 1 - 3, characterized in that, Comprising the following steps: Performing powder-making treatment on the solid components in the components to obtain corresponding powder components; Mixing the Cordyceps sinensis extract and Ganoderma atrum extract with a solvent and performing first stirring to obtain a suspension; Sequentially adding the Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Carthamus tinctorius flower extract, Glossy privet fruit extract, Ligusticum chuanxiong root extract, Angelica sinensis root extract, Panax ginseng root extract, Rosa roxburghii fruit extract, Portulaca oleracea extract, Cerasus serrulata var. lannesiana extract, ginsenoside, bifida yeast ferment filtrate, and recombinant type III collagen into the suspension and performing second stirring to obtain a mixture; Performing solvent removal treatment on the mixture to remove the solvent in the mixture and obtain a concentrated solution; Performing filtration treatment on the concentrated solution.

5. The preparation method according to claim 4, characterized in that, The stirring speed of the first stirring is 800-1000 rpm; the stirring time of the first stirring is 15-20 min; the stirring speed of the second stirring is 500-600 rpm; the stirring time of the second stirring is 30-45 min.

6. The preparation method according to claim 4, characterized in that, The particle size of the powder components obtained by the powder-making treatment is 80-100 mesh; the filtration treatment is performed using a microporous filter membrane with a pore size of 0.22-0.45 μm.

7. The preparation method according to any one of claims 4-6, characterized in that, The solvent is anhydrous ethanol; the solvent removal treatment is carried out by vacuum distillation, the temperature of the vacuum distillation is 40 - 50 °C, and the pressure of the vacuum distillation is 0.08 - 0.1 MPa.

8. An anti - hair - loss product, characterized in that, It includes the anti - hair - loss composition according to any one of claims 1 - 3.

9. The anti-hair loss product according to claim 8, characterized in that, The mass percentage of the anti - hair - loss composition in the anti - hair - loss product is 5% - 20%.

10. The anti - hair - loss product according to claim 8 or 9, characterized in that, The anti - hair - loss product includes shampoo, hair conditioner or hair mask.

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