Atomized medicine composition for treating filamentous keratitis as well as preparation method and application thereof

Abstract

The invention discloses an atomized medicine composition for treating filamentous keratitis. The atomized medicine composition is prepared from the following raw materials in parts by weight: 12 parts of radix rehmanniae, 12 parts of radix achyranthis bidentatae, 12 parts of radix angelicae sinensis, 12 parts of fructus aurantii, 12 parts of rhizoma seu radix notopterygii, 15 parts of radix saposhnikoviae, 9 parts of rhizoma chuanxiong, 20 parts of flos chrysanthemi, 9 parts of periostracum cicadae, 12 parts of herba schizonepetae, 15 parts of radix paeoniae alba, 9 parts of herba equiseti hiemalis, 15 parts of fructus lycii and 12 parts of semen cassiae. The preparation method comprises the following steps: injecting clear water into the mixed raw materials to submerge the Chinese herbal medicines, standing and soaking for half an hour, decocting to 200ml by slow fire, and filtering the medicine residue to obtain the atomized medicine composition for treating filamentous keratitis. 20-30ml of the liquid medicine is taken each time. The medicine composition can be used for treating filamentous keratitis, directly acts on eyes in a traditional Chinese medicine atomization mode, and is taken once a day, and 20-30 ml of medicine is taken once; the pharmaceutical composition disclosed by the invention is high in safety and small in side effect, and can achieve the curative effects of clearing liver, improving eyesight and removing nebula; the composition is combined with a cornea repairing agent to take effect quickly and has a good curative effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine pharmaceutical compositions, and particularly relates to an atomized pharmaceutical composition for treating filamentary keratitis, a preparation method thereof, and an application thereof. Background Art

[0002] Filamentary keratitis, also known as filamentary keratopathy, is a corneal disease characterized by partial exfoliation of the corneal epithelium, forming a coiled filamentous structure, with one end attached to the corneal surface and the other end in a free state. This disease can be secondary to various eye diseases, such as dry eye, neurotrophic keratopathy, cicatricial keratitis, etc., and can also be caused by factors such as corneal abrasion and intraocular surgery.

[0003] The main symptoms of the clinical manifestations of filamentary keratitis include red eyes, eye pain, foreign body sensation, photophobia, tearing, etc. In mild cases, there may only be a foreign body sensation in the eyes, while in severe cases, the corneal irritation symptoms are obvious. In terms of treatment, it is first necessary to remove the filaments, and then targeted treatment according to the cause, such as using drugs to promote corneal epithelial growth to relieve eye discomfort, wearing soft corneal contact lenses to protect the cornea, etc. For patients with recurrent attacks, surgical treatment may need to be considered.

[0004] The atomized treatment of filamentary keratitis is not a conventional treatment method, but with the development of medical technology, some new drug delivery methods are constantly being explored. Atomized treatment has become a potential treatment option. In the treatment of ocular surface diseases such as dry eye, a moist ocular environment can be provided for patients through atomization to relieve dry eye symptoms. For filamentary keratitis, in existing clinical treatments, it has been found that traditional lubricant treatments often fail to achieve ideal effects. Traditional Chinese medicine atomized drugs have the characteristics of safety and low side effects. Combining atomized traditional Chinese medicine with corneal repair agents can improve the curative effect.

[0005] Therefore, it is necessary to provide an atomized pharmaceutical composition for treating filamentary keratitis, which has the functions of clearing the liver, improving eyesight, and removing nebula, and at the same time provide its preparation method and specific application. To expand the treatment means of filamentary keratitis and improve the treatment effect. Summary of the Invention

[0006] In order to solve the above technical problems, an object of the present invention is to provide an atomized pharmaceutical composition for treating filamentary keratitis; In order to achieve the above technical object and technical effect, the present invention is realized through the following technical solutions: An atomizing pharmaceutical composition for treating filamentary keratitis: It is composed of the following raw materials in parts by weight: 10 - 14 parts of Rehmannia glutinosa, 10 - 14 parts of Achyranthes bidentata, 10 - 14 parts of Angelica sinensis, 10 - 14 parts of Aurantii Fructus Immaturus, 10 - 14 parts of Notopterygium incisum, 12 - 18 parts of Saposhnikovia divaricata, 7 - 11 parts of Ligusticum chuanxiong, 18 - 22 parts of Chrysanthemi Flos, 7 - 11 parts of Cryptotympana pustulata, 10 - 14 parts of Schizonepeta tenuifolia, 12 - 18 parts of Paeonia lactiflora, 7 - 11 parts of Equisetum hiemale, 12 - 18 parts of Lycii Fructus, 10 - 14 parts of Cassiae Semen; Further, an atomizing pharmaceutical composition for treating filamentary keratitis is composed of the following raw materials in parts by weight: 12 parts of Rehmannia glutinosa, 12 parts of Achyranthes bidentata, 12 parts of Angelica sinensis, 12 parts of Aurantii Fructus Immaturus, 12 parts of Notopterygium incisum, 15 parts of Saposhnikovia divaricata, 9 parts of Ligusticum chuanxiong, 20 parts of Chrysanthemi Flos, 9 parts of Cryptotympana pustulata, 12 parts of Schizonepeta tenuifolia, 15 parts of Paeonia lactiflora, 9 parts of Equisetum hiemale, 15 parts of Lycii Fructus, 12 parts of Cassiae Semen; Further, an atomizing pharmaceutical composition for treating filamentary keratitis is composed of the following raw materials in weight: 12 g of Rehmannia glutinosa, 12 g of Achyranthes bidentata, 12 g of Angelica sinensis, 12 g of Aurantii Fructus Immaturus, 12 g of Notopterygium incisum, 15 g of Saposhnikovia divaricata, 9 g of Ligusticum chuanxiong, 20 g of Chrysanthemi Flos, 9 g of Cryptotympana pustulata, 12 g of Schizonepeta tenuifolia, 15 g of Paeonia lactiflora, 9 g of Equisetum hiemale, 15 g of Lycii Fructus, 12 g of Cassiae Semen; Another object of the present invention is to provide a preparation method of an atomizing pharmaceutical composition for treating filamentary keratitis, including the following steps: Inject the raw materials in the above weight - gram ratio into clear water to submerge the Chinese herbal medicines. After soaking for half an hour, decoct them over a slow fire until 200 ml, and filter the medicinal residues; obtain an atomizing pharmaceutical composition for treating filamentary keratitis; Another object of the present invention is to provide an application of an atomizing pharmaceutical composition for treating filamentary keratitis, using the atomizing pharmaceutical composition for treating filamentary keratitis to treat filamentary keratitis; Further, apply the atomizing pharmaceutical composition for treating filamentary keratitis to the eyes in an atomizing manner. The dosage per administration is 20 - 30 ml, once a day; the atomizing time is 15 - 20 min; the distance between the nozzle and the eyelid is about 10 cm; The atomizing pharmaceutical composition of the present invention is a modern Chinese medicine designed according to the traditional Chinese medicine formula principle of monarch, minister, assistant, and guide. The effects of the raw medicinal materials used are as follows: Rehmannia glutinosa: Sweet, bitter, cold in nature; attributing to the heart, liver, and kidney meridians; having the effects of clearing heat and cooling blood, nourishing yin and promoting fluid production, stopping bleeding, calming the mind and relieving restlessness; mainly used for symptoms such as injury to yin caused by febrile diseases, crimson tongue and vexatious thirst, yin deficiency with internal heat, hectic fever due to yin deficiency, internal heat with thirst, bleeding due to blood - heat, constipation due to intestinal dryness, and restlessness of mind; Achyranthes bidentata: Pungent, bitter, and flat in flavor; attributing to the liver, kidney, and bladder meridians; having the effects of promoting blood circulation to remove blood stasis, tonifying the liver and kidney, strengthening tendons and bones, inducing diuresis for treating stranguria, and guiding blood downward; mainly used for symptoms such as amenorrhea, dysmenorrhea, lumbar and knee pain, weakness of tendons and bones, stranguria, edema, headache, dizziness, toothache, oral ulcer, and hematemesis; Angelica sinensis: Sweet, pungent, warm in nature; attributive to the liver, heart, and spleen meridians; with the effects of enriching blood, promoting blood circulation to remove blood stasis, regulating menstruation and relieving pain, moistening the intestines and relaxing bowel movements, and enhancing immunity; mainly used for various syndromes of blood deficiency: irregular menstruation, cold or blood stasis pain syndromes, carbuncles and sores, and intestinal dryness and constipation; Fructus Aurantii: Bitter, pungent, sour in taste, slightly cold in nature; with the effects of regulating qi and widening the middle-jiao, promoting qi movement to relieve distension, anti-ulcer, analgesic, anti-shock, resolving phlegm and relieving stuffiness, lifting yang and raising prolapse, etc.; mainly used for: chest and hypochondrium qi stagnation, fullness and pain, treating indigestion, gastrointestinal dysfunction, treating peptic ulcer, assisting in treating shock, phlegm retention, organ prolapse and other symptoms; Notopterygium incisum: Warm in nature, pungent and bitter in taste; attributive to the bladder and kidney meridians; with the effects of inducing sweating to dispel cold, expelling wind and removing dampness, relieving pain, anti-inflammatory, and relaxing muscles and tendons; mainly used for wind-cold cold, rheumatic arthralgia, relieving pain, anti-inflammatory, and relaxing muscles and tendons; Saposhnikovia divaricata: Pungent and sweet in taste, slightly warm in nature, attributive to the bladder, lung, spleen, and liver meridians; with the effects of expelling wind and inducing sweating, relieving pain due to dampness, stopping convulsions, antibacterial and anti-inflammatory, sweating, stopping sweating, antidiarrheal, and laxative; mainly used for: cold, relieving arthritis pain, improving dyspepsia, treating rubella pruritus, treating tetanus, sores and ulcers, etc.; Ligusticum chuanxiong: Pungent in taste, warm in nature, attributive to the liver, gallbladder, and pericardium meridians; with the effects of promoting blood circulation and regulating qi, dispelling wind and relieving pain, regulating menstruation and relieving pain, anti-radiation, anti-aging, anti-tumor, and improving microcirculation; mainly used for: treating cardiovascular and cerebrovascular diseases, treating gynecological diseases, treating rheumatic arthralgia, treating headache, treating traumatic injury, sores and swelling pain, etc.; Chrysanthemum morifolium: Bitter and sweet in taste, slightly cold in nature, attributive to the lung and liver meridians; with the effects of dispersing wind-heat, suppressing liver yang, clearing the eyes and removing toxicity; mainly used for treating wind-heat cold, relieving symptoms of hyperactive liver yang, improving eye discomfort, treating sores and carbuncles, and health care; Cryptotympana pustulata: Cool in nature, sweet and salty in taste; attributive to the lung and liver meridians; with the effects of dispersing wind-heat, relieving sore throat and promoting phonation, erupting rashes, removing nebula and improving eyesight, calming endogenous wind and stopping convulsions; mainly used for treating wind-heat cold, relieving throat discomfort, treating rashes, improving eye symptoms, and relieving infantile convulsions; Schizonepeta tenuifolia: Pungent, slightly warm in nature, attributive to the lung and liver meridians; with the effects of inducing sweating to disperse wind, erupting rashes and relieving itching, stopping bleeding, anti-inflammatory and detoxifying, relieving sore throat and relieving cough, calming the mind; mainly used for treating exterior syndrome due to exogenous pathogens, measles, rubella, bleeding disorders, sores and carbuncles, sore throat, cough symptoms, and relieving anxiety and insomnia; Paeonia lactiflora: Bitter, sour, sweet in taste, slightly cold in nature; with the effects of suppressing the hyperactive liver to relieve pain, regulating menstruation by enriching blood, protecting liver function, dilating coronary arteries, reducing blood pressure, analgesic, anti-inflammatory, and antioxidant; mainly used for treating gynecological diseases, treating pain syndromes, protecting cardiovascular health, and enhancing immunity; Horsetail: mild in nature, sweet and bitter in taste; it belongs to the lung, liver and gallbladder meridians; it has the effects of dispelling wind and heat, improving eyesight and removing cataracts, cooling blood and stopping bleeding, anti-inflammatory and antibacterial, and moistening the intestines and relieving constipation; it is usually used to treat ophthalmic diseases, such as red and swollen eyes, tears in the wind, cloudiness of the eyes, etc., to treat bleeding symptoms, to treat intestinal diseases, to treat sore throat, carbuncle, malaria, hernia pain, and rectal prolapse; Lycium barbarum: sweet and neutral in nature, it belongs to the liver and kidney meridians; it has the effects of nourishing the liver and kidney, improving the eyesight, moistening the lungs and relieving cough, immune regulation, anti-aging, lowering blood pressure, lowering blood sugar, regulating blood lipids, replenishing qi, strengthening sperm, and relieving thirst; it is mainly used for medicine, diet therapy, and health care, and is suitable for long-term use to maintain good health; Cassia seed: sweet, bitter, salty, slightly cold in nature; enters the liver and large intestine meridians; has the effects of clearing the liver and improving eyesight, moistening the intestines and relieving constipation, lowering blood lipids and blood pressure, antibacterial and anti-inflammatory, clearing away heat and purging fire, and anti-tumor; mainly used for: medicinal, dietary therapy and health care; The atomized pharmaceutical composition for treating filamentary keratitis of the present invention is used for treating filamentary keratitis. The cornea is called "black eye" in traditional Chinese medicine, and it is located on the surface. Saposhnikovia, Nepeta, Notopterygium, and Equisetum have the effect of dispelling wind and dispersing evil. Black eye disease is treated from the perspective of the liver meridian. Chrysanthemum, Cassia seed, and Cicadae Periostracum clear the liver, improve eyesight, and remove cataracts. How long does filamentary keratitis last? Achyranthes bidentata, Citrus aurantium, and Chuanxiong are used to promote qi and blood circulation, and Radix Rehmanniae, Angelicae Sinensis, and Lycium barbarum nourish yin and blood, which together play the effect of strengthening the body and eliminating evil.

[0007] Beneficial effects of the present invention: The Chinese medicinal composition of the present invention uses chrysanthemum, cassia seed and cicada shell as main medicines and treats from the perspective of liver meridian; cornea, which is called "black eye" in traditional Chinese medicine, is located on the surface; the medicinal composition uses siler, schizonepeta, angelica root and horsetail to take the effects of dispelling wind and dispersing evil; filamentous keratitis is mostly a long-term disease, and the medicinal composition takes the effects of Achyranthes bidentata, Citrus aurantium and Ligusticum chuanxiong on promoting qi and activating blood circulation; takes the effects of Rehmannia glutinosa, Chinese angelica and wolfberry on nourishing yin and blood; the whole formula works together to strengthen the body and eliminate evil; the whole formula is targeted at filamentary keratitis and has the effects of clearing the liver, improving eyesight and removing cataracts. DETAILED DESCRIPTION

[0008] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Embodiment 1:

[0009] In this embodiment, an atomized pharmaceutical composition for treating filamentary keratitis is composed of the following raw materials in parts by weight: 10-14 parts of Rehmannia glutinosa, 10-14 parts of Achyranthes bidentata, 10-14 parts of Angelica sinensis, 10-14 parts of Aurantii Fructus Immaturus, 10-14 parts of Notopterygium incisum, 12-18 parts of Saposhnikovia divaricata, 7-11 parts of Ligusticum chuanxiong, 18-22 parts of Chrysanthemi Flos, 7-11 parts of Cryptotympana pustulata, 10-14 parts of Schizonepeta tenuifolia, 12-18 parts of Paeonia lactiflora, 7-11 parts of Equisetum hiemale, 12-18 parts of Lycii Fructus, 10-14 parts of Cassiae Semen; Example 2:

[0010] In this embodiment, an atomized pharmaceutical composition for treating filamentary keratitis is composed of the following raw materials in parts by weight: 12 parts of Rehmannia glutinosa, 12 parts of Achyranthes bidentata, 12 parts of Angelica sinensis, 12 parts of Aurantii Fructus Immaturus, 12 parts of Notopterygium incisum, 15 parts of Saposhnikovia divaricata, 9 parts of Ligusticum chuanxiong, 20 parts of Chrysanthemi Flos, 9 parts of Cryptotympana pustulata, 12 parts of Schizonepeta tenuifolia, 15 parts of Paeonia lactiflora, 9 parts of Equisetum hiemale, 15 parts of Lycii Fructus, 12 parts of Cassiae Semen; Example 3:

[0011] In this embodiment, an atomized pharmaceutical composition for treating filamentary keratitis is composed of the following raw materials in weight: 12 g of Rehmannia glutinosa, 12 g of Achyranthes bidentata, 12 g of Angelica sinensis, 12 g of Aurantii Fructus Immaturus, 12 g of Notopterygium incisum, 15 g of Saposhnikovia divaricata, 9 g of Ligusticum chuanxiong, 20 g of Chrysanthemi Flos, 9 g of Cryptotympana pustulata, 12 g of Schizonepeta tenuifolia, 15 g of Paeonia lactiflora, 9 g of Equisetum hiemale, 15 g of Lycii Fructus, 12 g of Cassiae Semen; Example 4:

[0012] In this embodiment, the preparation process of an atomized pharmaceutical composition for treating filamentary keratitis is as follows: including the following steps: Inject the following raw materials in parts by weight: Pour in clear water to cover the Chinese herbal medicines, soak for half an hour, then decoct over low heat until 200 ml, and filter the medicinal residues; Obtain an atomized pharmaceutical composition for treating filamentary keratitis; 12 g of Rehmannia glutinosa, 12 g of Achyranthes bidentata, 12 g of Angelica sinensis, 12 g of Aurantii Fructus Immaturus, 12 g of Notopterygium incisum, 15 g of Saposhnikovia divaricata, 9 g of Ligusticum chuanxiong, 20 g of Chrysanthemi Flos, 9 g of Cryptotympana pustulata, 12 g of Schizonepeta tenuifolia, 15 g of Paeonia lactiflora, 9 g of Equisetum hiemale, 15 g of Lycii Fructus, 12 g of Cassiae Semen; Example 5:

[0013] In this embodiment, the usage, dosage and efficacy of an atomized pharmaceutical composition for treating filamentary keratitis are as follows: Usage and dosage: Take 20-30 ml of the medicinal liquid each time, and act on the eyes in an atomized manner; Once a day; The atomization time is 15-20 min; The distance between the nozzle and the eyelid is about 10 cm; Function and indication: Clearing the liver, improving eyesight and removing nebula; Taboo: Corneal laceration, those allergic to the contained Chinese medicine components, and asthma patients are prohibited. Example 6:

[0014] Typical cases: Case 1: Patient Wang, female, 50 years old, outpatient number 00000XXXXX, from Yanchang County, Shaanxi Province. She came for diagnosis with the chief complaint of "gritty sensation in both eyes for more than 1 month". She had suffered from "dry eye syndrome" for 2 years. One month ago, she felt gritty and uncomfortable in both eyes and used recombinant bovine basic fibroblast growth factor eye gel by herself, but there was no obvious improvement, so she came for diagnosis. Special examination: Visual acuity OD 0.6, OS 0.8, intraocular pressure Tn. Both eyelids were not swollen or red, the conjunctiva was slightly congested, scattered filamentous infiltrations were visible under the cornea, the anterior chamber was (-), the iris texture was clear, the pupil was round, about 3 mm in diameter, the light reaction was normal, and the lens was slightly cloudy. The tongue was red, the coating was thin and yellow, and the pulse was rapid.

[0015] The patient was given ocular atomization with an atomized pharmaceutical composition for treating filamentary keratitis prepared in Example 4 of the present invention once a day, combined with recombinant bovine basic fibroblast growth factor eye gel for eye drops. After two days of treatment, the corneal lesions disappeared and the symptoms vanished.

[0016] Case 2: Patient An, female, 54 years old, outpatient number XXXXXXX, from Xi'an City, Shaanxi Province. She came for diagnosis with the chief complaint of "photophobia and lacrimation in both eyes for 2 months". She was diagnosed with "Sjögren's syndrome" in another hospital 1 year ago and was given oral traditional Chinese medicine intermittently (details unknown). Special examination: Visual acuity OD 1.2, OS 1.0, intraocular pressure Tn. Both eyelids were not swollen or red, the conjunctiva was slightly congested, scattered filamentous infiltrations were visible on the cornea, the anterior chamber was (-), the iris texture was clear, the pupil was round, about 3 mm in diameter, the light reaction was normal, and the lens was transparent. The tongue was red, the coating was thin and yellow, and the pulse was thready and rapid.

[0017] The patient was given ocular atomization with an atomized pharmaceutical composition for treating filamentary keratitis prepared in Example 4 of the present invention once a day, combined with recombinant bovine basic fibroblast growth factor eye gel for eye drops. After five days of continuous treatment, the symptoms disappeared, and the lesions completely disappeared on the 7th day. Example 7:

[0018] In traditional Chinese medicine, the cornea is called "black eye". It is located on the surface. Ledebouriella seseloides, Schizonepeta tenuifolia, Notopterygium incisum, and Equisetum hiemale are used to dispel wind and pathogenic factors. Diseases of the black eye are treated from the liver meridian. Chrysanthemum morifolium, Cassia obtusifolia, and Cryptotympana pustulata clear the liver, improve eyesight, and remove nebula. For the duration of filamentary keratitis, Achyranthes bidentata, Citrus aurantium, and Ligusticum wallichii promote qi and activate blood circulation, and Rehmannia glutinosa, Angelica sinensis, and Lycium barbarum nourish yin and blood, jointly playing the role of strengthening the healthy qi and eliminating pathogenic factors.

[0019] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification to better explain the principle and practical application of the present invention, so that those skilled in the relevant technical field can well understand and utilize the present invention. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. An atomized pharmaceutical composition for treating filamentary keratitis, characterized in that, It is composed of the following raw materials in parts by weight: 10 - 14 parts of Rehmannia glutinosa, 10 - 14 parts of Achyranthes bidentata, 10 - 14 parts of Angelica sinensis, 10 - 14 parts of Aurantii Fructus Immaturus, 10 - 14 parts of Notopterygium incisum, 12 - 18 parts of Saposhnikovia divaricata, 7 - 11 parts of Ligusticum chuanxiong, 18 - 22 parts of Chrysanthemi Flos, 7 - 11 parts of Cryptotympana pustulata, 10 - 14 parts of Schizonepeta tenuifolia, 12 - 18 parts of Paeonia lactiflora, 7 - 11 parts of Equisetum hiemale, 12 - 18 parts of Lycii Fructus, 10 - 14 parts of Cassiae Semen.

2. The atomized pharmaceutical composition for treating filamentary keratitis according to claim 1, wherein It is composed of the following raw materials in parts by weight: 12 parts of Rehmannia glutinosa, 12 parts of Achyranthes bidentata, 12 parts of Angelica sinensis, 12 parts of Aurantii Fructus Immaturus, 12 parts of Notopterygium incisum, 15 parts of Saposhnikovia divaricata, 9 parts of Ligusticum chuanxiong, 20 parts of Chrysanthemi Flos, 9 parts of Cryptotympana pustulata, 12 parts of Schizonepeta tenuifolia, 15 parts of Paeonia lactiflora, 9 parts of Equisetum hiemale, 15 parts of Lycii Fructus, 12 parts of Cassiae Semen.

3. The atomized pharmaceutical composition for treating filamentary keratitis according to claim 1, wherein It is composed of the following raw materials in grams: 12 g of Rehmannia glutinosa, 12 g of Achyranthes bidentata, 12 g of Angelica sinensis, 12 g of Aurantii Fructus Immaturus, 12 g of Notopterygium incisum, 15 g of Saposhnikovia divaricata, 9 g of Ligusticum chuanxiong, 20 g of Chrysanthemi Flos, 9 g of Cryptotympana pustulata, 12 g of Schizonepeta tenuifolia, 15 g of Paeonia lactiflora, 9 g of Equisetum hiemale, 15 g of Lycii Fructus, 12 g of Cassiae Semen.

4. A preparation method of an atomized pharmaceutical composition for treating filamentary keratitis, characterized in that, It includes the following steps: According to the parts by weight of any one of claims 1 - 3, mix the raw materials to obtain a mixed raw material; put the mixed raw material into water, soak it and then decoct it to obtain a mixed medicinal liquid, filter the solid substances, and take the medicinal liquid; the medicinal liquid is an atomized pharmaceutical composition for treating filamentary keratitis.

5. The preparation method of an atomized pharmaceutical composition for treating filamentary keratitis according to claim 1, wherein, The soaking time is 25 - 35 minutes; the decocting fire is slow fire; the solid - liquid mass ratio of the obtained mixed medicinal liquid after decocting is: 1.7~1.8:

2.

6. Use of an atomized pharmaceutical composition for treating filamentary keratitis, characterized in that, Use the atomized pharmaceutical composition for treating filamentary keratitis according to any one of claims 1 - 5 to treat filamentary keratitis.

7. Use of an atomized pharmaceutical composition for treating filamentary keratitis as claimed in claim 6, characterized in that, Act on the eyes in the way of ultrasonic atomization with the atomized pharmaceutical composition for treating filamentary keratitis.

8. Use of an atomized pharmaceutical composition for treating filamentary keratitis according to claim 7, characterized in that, The dosage of the ultrasonic atomization medicine each time is 20 - 30 ml, once a day, and the atomization time each time is 15 - 20 minutes; when atomizing, the nozzle is 8 - 12 cm away from the eyelid.