Preparation method of traditional Chinese medicine preparation for treating vitiligo

Abstract

The invention discloses a preparation method of a traditional Chinese medicine preparation for treating vitiligo, and relates to the field of preparation of traditional Chinese medicine preparations, the preparation method of the traditional Chinese medicine preparation for treating vitiligo comprises the following steps: S1, selecting traditional Chinese medicinal materials; the preparation method comprises the following steps: firstly, selecting traditional Chinese medicinal materials including caulis clematidis armandii, radix achyranthis bidentatae, rhizoma anemarrhenae, radix saposhnikoviae, fructus forsythiae, fructus gardeniae, agastache rugosus, rhizoma acori graminei, radix sophorae flavescentis, herba eupatorii, native copper, carbonized hair, flaxseed and radix rehmanniae preparata, and then performing coarse material treatment for later use; the traditional Chinese medicine composition has the effects of effectively scavenging free radicals, inhibiting expression of AKT and extracellular signal regulation kinase and protecting oxidative damage, can inhibit mast cell histamine, can block signal transduction of hydrogen monoxide to regulate and control expression of melanocytes, and can be used for sterilizing, inhibiting bacteria and reducing microbial proliferation; meanwhile, the traditional Chinese medicine composition has the effects of dispelling wind, detoxifying, killing parasites and relieving itching, and can treat the syndrome of wind evil and damp toxin obstructing skin.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine preparation, and in particular to a method for preparing a traditional Chinese medicine preparation for treating vitiligo. Background Art

[0002] Vitiligo is a non-infectious disease, mainly manifested as one or several white patches of different sizes, usually without self-awareness symptoms. In extremely rare cases, patients may have a certain degree of itching in the initial stage and progressive stage of the disease development. Vitiligo may also be complicated with other systemic diseases, such as thyroid diseases, autoimmune polyendocrine syndrome, etc. The treatment of vitiligo mainly includes drug treatment, phototherapy, hormone treatment, and small-area skin transplantation, etc. The treatment plans for different patients may vary due to disease conditions and individual differences. Drug treatment mainly includes the application of hormones, calcineurin inhibitors, and vitamin D3 derivatives, as well as clinical measures to avoid inducing factors; while phototherapy mainly removes the skin epidermis to improve the color. The indication for medical treatment is the appearance of large white patches on the skin, and the white patches are aggravated after fatigue and sun exposure.

[0003] When the traditional Chinese medicine preparation for treating vitiligo is used, the overall use effect is relatively poor, the curative effect of the drug cannot be guaranteed, and there are certain toxic and side effects. It cannot be used for local differentiation and treatment through external application, and it is difficult to accurately treat specific parts. It is difficult to effectively treat vitiligo with complex pathogenesis. It cannot effectively scavenge free radicals, inhibit the expression of AKT and extracellular signal-regulated kinases, protect against oxidative damage, it is difficult to inhibit mast cell histamine, cannot block the nitric oxide melanin signal transduction to regulate the expression of melanocytes, it is difficult to sterilize, inhibit bacteria, and reduce the proliferation of microorganisms. At the same time, it cannot dispel wind, detoxify, kill insects and relieve itching, and it is difficult to treat the syndrome of wind pathogen and damp toxin congesting the skin.

[0004] Therefore, the technical personnel in the field provide a method for preparing a traditional Chinese medicine preparation for treating vitiligo to solve the problems put forward in the above background art. Summary of the Invention

[0005] The object of the present invention is to provide a preparation method of a traditional Chinese medicine preparation for treating vitiligo, so as to solve the problems mentioned in the above background technology. When the traditional Chinese medicine preparation for treating vitiligo is used, the overall use effect is poor, the curative effect of the medicine cannot be guaranteed, and there are certain toxic and side effects. It cannot be locally differentiated and treated through external application, it is difficult to accurately treat specific parts, it is difficult to effectively treat vitiligo with complex and refractory pathogenesis, it cannot effectively scavenge free radicals, inhibit the expression of AKT and extracellular signal-regulated kinase, protect against oxidative damage, it is difficult to inhibit histamine of mast cells, it cannot block the melanin signal transduction of nitric oxide to regulate the expression of melanocytes, it is difficult to sterilize, inhibit bacteria, and reduce the proliferation of microorganisms. At the same time, it cannot dispel wind, detoxify, kill insects and relieve itching, and it is difficult to treat the syndrome of wind pathogen and damp-toxin stagnating in the skin.

[0006] To achieve the above object, the present invention provides the following technical solutions: A preparation method of a traditional Chinese medicine preparation for treating vitiligo, the preparation method of the traditional Chinese medicine preparation for treating vitiligo includes the following steps: S1: the step of selecting Chinese medicinal materials, firstly, selecting Chinese medicinal materials including Chuanmutong, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Cyperus rotundus, natural copper, charcoal from blood, sesame seeds and Rehmannia glutinosa, then processing the coarse materials and setting them aside, in the process of calcining natural copper, taking clean natural copper, calcining it until it is red, and immediately putting it into vinegar to quench it, repeating it three times, the amount of vinegar used is 30% of the amount of Chinese medicinal materials, and then crushing it after drying; S2: the step of processing medicinal materials, the coarse materials of Chinese medicinal materials including Chuanmutong, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Cyperus rotundus, natural copper, charcoal from blood, sesame seeds and Rehmannia glutinosa need to be soaked in sesame oil, and then strictly follow the ancient principle of extending the soaking time in spring, autumn and winter to ensure that the effective ingredients are fully dissolved, and then control the oil temperature to simmer it over a low heat, and boil the medicinal materials until the surface is dark brown and the inside is brown, and the temperature is precisely controlled. Heat the oil to remove the residue and keep the properties, remove the residue from the heat and filter it out, and put the filtered medicinal oil back into the refining container; S3: oil refining and paste-forming steps, the oil refining temperature is raised to 280-300℃, and the changes in oil smoke are observed. When the blue smoke turns to white smoke and the medicinal oil forms beads when dripping with water, the water droplet forming method is used to judge whether it is refined. When the medicinal oil is light yellow and transparent, take a small amount and drop it in cold water. When golden yellow oil beads sink to the bottom, the viscosity of the medicinal oil reaches the best state. Add the pill according to the proportion, stir clockwise at a uniform speed until the paste has a black and shiny luster and continuous drawing, and immediately remove from the heat and cool down; S4: detoxification treatment step, first cool the refined paste to 80℃ and add fine materials to avoid the loss of volatile components due to high temperature, and then perform detoxification treatment, immerse the finished product in running cold water, change the water every day for 7 days, and completely precipitate the irritating substances. S5: packaging step, add the paste after the fire poison removal treatment into the tubular shell, and then seal the top of the tubular shell. The tubular shell can be made of medical grade aluminum tube, which must meet the YBB00152002 standard, and the filling environment must reach the GMP 100,000 cleanliness level. Complete the inner packaging step, and then cover the outer packaging of the tubular shell with the Chinese medicine preparation. As a preferred embodiment of the present invention: in the selection step of the Chinese medicinal materials, 3 grams of Sichuan Atractylodes, 3 grams of Achyranthes bidentata, 6 grams of Anemarrhena asphodeloides, 6 grams of Saposhnikovia divaricata, 6 grams of Forsythia suspensa, 9 grams of Gardenia jasminoides, 9 grams of Patchouli, 9 grams of Acorus calamus, 9 grams of Sophora flavescens, 15 grams of Perilla frutescens, 15 grams of natural copper, 15 grams of Sanguisorba officinalis, 15 grams of large sesame seeds and 15 grams of Rehmannia glutinosa can be selected. The Sichuan Atractylodes lancea is originally Akebia of the Akebia family.

[0007] As a preferred embodiment of the present invention: in the medicinal material processing step, the soaking time can be 5 days in spring and autumn, and can be extended to 7 days in winter, and the oil temperature is controlled at 220°C during the slow fire refining stage.

[0008] As a preferred embodiment of the present invention: in the step of selecting traditional Chinese medicinal materials, after selecting Clematidis Armandii Caulis, Achyranthes Bidentata, Anemarrhena Asphodeloides, Saposhnikovia Divaricata, Forsythia Suspensa, Gardenia Jasminoides, Pogostemon Cablin, Acorus Tatarinowii, Sophora Flavescens, Eupatorium Fortunei, Pyritum, Carbonized Human Hair, Sesame Seeds and Rehmannia Glutinosa, they need to be washed and then dried. During the drying process, charcoal drying can be selected. Compared with open fire, charcoal can provide a more stable temperature and fully preserve the medicinal effects. After drying, they are ground into powder for standby.

[0009] As a preferred embodiment of the present invention: in the step of selecting traditional Chinese medicinal materials, when grinding Clematidis Armandii Caulis, Achyranthes Bidentata, Anemarrhena Asphodeloides, Saposhnikovia Divaricata, Forsythia Suspensa, Gardenia Jasminoides, Pogostemon Cablin, Acorus Tatarinowii, Sophora Flavescens, Eupatorium Fortunei, Pyritum, Carbonized Human Hair, Sesame Seeds and Rehmannia Glutinosa into powder, cutting, grinding and pounding methods can be selected for the step of shaping the traditional Chinese medicinal materials, for preparing the paste.

[0010] As a preferred embodiment of the present invention: in the packaging step, when adding the paste to the tubular shell, attention should be paid to the sanitary conditions at all times, and the operation needs to be carried out in a sterilized environment, and the contaminated paste should be removed in time to ensure the thoroughness of sterilization.

[0011] As a preferred embodiment of the present invention: in the packaging step, when adding the paste to the tubular shell, an automatic paste packaging machine can be used for packaging, and a triangular bag paste packaging machine can be selected to finally press the tubular shell into a triangular bag shape.

[0012] Compared with the prior art, the beneficial effects of the present invention are: The preparation method of a traditional Chinese medicine preparation for treating vitiligo of the present invention follows the principle that treating wind first requires treating blood, and when the blood circulates smoothly, the wind will disappear by itself. Through: ① Rehmannia Glutinosa and Achyranthes Bidentata nourish yin and blood (the monarch drugs); ② Saposhnikovia Divaricata and Eupatorium Fortunei dispel wind and remove dampness (the minister drugs); ③ Pyritum and Carbonized Human Hair activate blood circulation and dredge collaterals (the assistant drugs); ④ Gardenia Jasminoides and Forsythia Suspensa clear heat and cool blood (the envoy drugs); the four methods cooperate together to achieve the effects of regulating nutrient qi and blood, dispelling wind and activating blood circulation. The dosage standard is that the externally applied area per day does not exceed 5% of the body surface, and continuous use does not exceed 3 months. Pregnant patients are prohibited. The prescription idea is derived from the modification of Fuping Pills in Golden Mirror of Medicine and Tongqiao Huoxue Decoction in Correcting Errors in Medicine. It can change the poor overall use effect of traditional Chinese medicine preparations for treating vitiligo during use, ensure the curative effect of the medicine, avoid side effects, can carry out local syndrome differentiation and treatment through external application, can accurately treat specific parts, can effectively treat vitiligo with complex and difficult-to-treat pathogenesis, can effectively scavenge free radicals, inhibit the expression of AKT and extracellular signal-regulated kinases, protect against oxidative damage, can inhibit histamine of mast cells, and at the same time can block the nitric oxide melanin signal transduction to regulate the expression of melanocytes, can sterilize, inhibit bacteria, reduce the proliferation of microorganisms, and at the same time can dispel wind, detoxify, kill insects and relieve itching, and treat the syndrome of wind pathogen and damp toxin congesting the skin. DETAILED DESCRIPTION

[0013] In an embodiment of the present invention, a method for preparing a Chinese medicine preparation for treating vitiligo comprises the following steps: S1: the step of selecting Chinese medicinal materials, firstly, selecting Chinese medicinal materials including Chuanmutong, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Cyperus rotundus, natural copper, charcoal from blood, sesame seeds and Rehmannia glutinosa, then processing the coarse materials and setting them aside, in the process of calcining natural copper, taking clean natural copper, calcining it until it is red, and immediately putting it into vinegar to quench it, repeating it three times, the amount of vinegar used is 30% of the amount of Chinese medicinal materials, and then crushing it after drying; S2: the step of processing medicinal materials, the coarse materials of Chinese medicinal materials including Chuanmutong, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Cyperus rotundus, natural copper, charcoal from blood, sesame seeds and Rehmannia glutinosa need to be soaked in sesame oil, and then strictly follow the ancient principle of extending the soaking time in spring, autumn and winter to ensure that the effective ingredients are fully dissolved, and then control the oil temperature to simmer it over a low heat, and boil the medicinal materials until the surface is dark brown and the inside is brown, and the temperature is precisely controlled. Heat the oil to remove the residue and keep the properties, remove the residue from the heat and filter it out, and put the filtered medicinal oil back into the refining container; S3: oil refining and paste-forming steps, the oil refining temperature is raised to 280-300℃, and the changes in oil smoke are observed. When the blue smoke turns to white smoke and the medicinal oil forms beads when dripping with water, the water droplet forming method is used to judge whether it is refined. When the medicinal oil is light yellow and transparent, take a small amount and drop it in cold water. When golden yellow oil beads sink to the bottom, the viscosity of the medicinal oil reaches the best state. Add the pill according to the proportion, stir clockwise at a uniform speed until the paste has a black and shiny luster and continuous drawing, and immediately remove from the heat and cool down; S4: detoxification treatment step, first cool the refined paste to 80℃ and add fine materials to avoid the loss of volatile components due to high temperature, and then perform detoxification treatment, immerse the finished product in running cold water, change the water every day for 7 days, and completely precipitate the irritating substances. S5: Packaging step, adding the paste after the detoxification treatment into the tubular shell, and then sealing the top of the tubular shell. The tubular shell can be made of medical grade aluminum tube, which must comply with the YBB00152002 standard. The filling environment must reach the GMP 100,000 cleanliness level. After completing the inner packaging step, the outer shell of the tubular shell is covered with the outer packaging of the traditional Chinese medicine preparation.

[0014] It can change the poor overall effect of traditional Chinese medicine preparations for the treatment of vitiligo, ensure the efficacy of the drug, avoid toxic side effects, and perform local treatment through external administration. It can accurately treat specific parts and effectively treat vitiligo with complex and difficult pathogenesis. In the selection step of Chinese medicinal materials, 3 grams of Sichuan Atractylodes, 3 grams of Achyranthes, 6 grams of Anemarrhena, 6 grams of Saposhnikovia, 6 grams of Forsythia, 9 grams of Gardenia, 9 grams of Patchouli, 9 grams of Acorus, 9 grams of Sophora flavescens, 15 grams of Perilla, 15 grams of Natural Copper, 15 grams of Sanguisorba officinalis, 15 grams of Sesame Seed and 15 grams of Rehmannia glutinosa can be selected. Sichuan Atractylodes is originally from Akebia. In the medicinal material processing step, the soaking time can be 5 days in spring and autumn, and the soaking time can be extended to 7 days in winter, and the oil temperature can be controlled at 220℃ during the slow fire refining stage. In the selection step of Chinese medicinal materials, after selecting Sichuan Atractylodes, Achyranthes bidentata, Anemarrhena, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Perilla frutescens, natural copper, Blood charcoal, large sesame seeds and Radix Rehmanniae glutinosae Chinese medicinal materials, it is necessary to clean and then dry, and charcoal fire can be selected for drying during the drying process. Charcoal fire can provide a more stable temperature relative to an open flame, fully preserve the efficacy, and be ground into powder for standby use after drying. In the selection step of Chinese medicinal materials, when Sichuan Atractylodes bidentata, Achyranthes bidentata, Anemarrhena, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Patchouli, Acorus calamus, Sophora flavescens, Perilla frutescens, natural copper, Blood charcoal, large sesame seeds and Radix Rehmanniae glutinosae Chinese medicinal materials are ground into powder, cutting, grinding and pestle methods can be selected to carry out the Chinese medicinal materials reshaping step, in preparation for paste making. In the packaging step, when the paste is added to the tubular shell operation, it should always pay attention to sanitary conditions, and it is necessary to operate under a sterilized environment, and the contaminated paste is promptly removed to ensure the thoroughness of sterilization. In the packaging step, when the paste is added to the tubular shell, an automated paste packaging machine may be used for packaging, and a triangular package paste packaging machine may be selected to finally press the tubular shell into a triangular package shape.

[0015] It can effectively scavenge free radicals, inhibit the expression of AKT and extracellular signal-regulated kinase, and protect against oxidative damage. It can inhibit mast cell histamine and block the hydrogen monoxide melanin signal transduction to regulate the expression of melanocytes. It can kill bacteria, inhibit bacteria, and reduce microbial proliferation. It can also dispel wind, detoxify, kill insects and relieve itching, and treat wind evil and dampness toxins blocking the skin.

[0016] The working principle of the present invention is: a method for preparing a traditional Chinese medicine preparation for treating vitiligo comprises the following steps: S1: The step of selecting traditional Chinese medicines. First, select Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized Human Hair, Sesamum indicum seeds and Rehmannia glutinosa, and then carry out rough material treatment. After treatment, set aside for use. In the process of calcining Pyritum, take pure Pyritum, calcine it until it is completely red, and immediately put it into vinegar to quench and make it crispy. Repeat this three times. The amount of vinegar used is 30% of the amount of traditional Chinese medicines. After drying, crush it. In the step of selecting traditional Chinese medicines, it is possible to select 3 grams of Caulis Clematidis Armandii, 3 grams of each Achyranthes bidentata, 6 grams of Anemarrhena asphodeloides, 6 grams of Saposhnikovia divaricata, 6 grams of Forsythia suspensa, 9 grams of Gardenia jasminoides, 9 grams of Pogostemon cablin, 9 grams of Acorus tatarinowii, 9 grams of Sophora flavescens, 15 grams of Eupatorium fortunei, 15 grams of Pyritum, 15 grams of Carbonized Human Hair, 15 grams of Sesamum indicum seeds and 15 grams of Rehmannia glutinosa. The original source of Caulis Clematidis Armandii is Lardizabalaceae Akebia quinata. In the step of selecting traditional Chinese medicines, when grinding Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized Human Hair, Sesamum indicum seeds and Rehmannia glutinosa into powder, it is possible to select cutting, grinding and pounding methods for the step of shaping traditional Chinese medicines for use in making ointment. S2: The step of processing traditional Chinese medicines. The rough materials of Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized Human Hair, Sesamum indicum seeds and Rehmannia glutinosa need to be soaked in sesame oil, and then strictly follow the ancient principle of extending the soaking time in spring and autumn and winter to ensure that the active ingredients are fully dissolved. Then, control the oil temperature and carry out slow cooking over a gentle fire. Cook the traditional Chinese medicines until the surface is dark brown and the inside is charred yellow. Precisely grasp the cooking time to remove the residue and keep the essence. Remove the fire and filter to remove the medicinal residues. Put the filtered medicinal oil back into the refining container. In the step of processing traditional Chinese medicines, the soaking time can be 5 days in spring and autumn, and extended to 7 days in winter, and control the oil temperature at 220 °C during the slow cooking stage over a gentle fire. In the step of selecting traditional Chinese medicines, after selecting Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized Human Hair, Sesamum indicum seeds and Rehmannia glutinosa, it is necessary to wash them and then dry them. During the drying process, it is possible to select drying with charcoal fire. Compared with open fire, charcoal fire can provide a more stable temperature and fully preserve the medicinal effect. After drying, grind them into powder for standby. S3: The steps of refining oil and making ointment. Raise the temperature of the refined oil to 280 - 300 °C. By observing the change of the oil fume, when the phenomenon of green smoke turning into white smoke and the phenomenon of the medicinal oil forming into beads when dripping water occur, use the method of dripping water to judge whether it is refined. When the medicinal oil shows a light yellow transparent state, take a little and drop it into cold water. When it forms a golden yellow oil bead that sinks to the bottom, at this time, the viscosity of the medicinal oil reaches the best state. Add lead oxide according to the proportion and stir clockwise at a constant speed until the ointment shows a black and bright luster and can be continuously drawn into filaments. Immediately remove the fire and cool down. S4: The step of removing fire toxins. First, cool the ointment after refining to 80 °C and add fine materials to avoid the loss of volatile components caused by high temperature. Then carry out the step of removing fire toxins. Immerse the finished product in flowing cold water and change the water every day for 7 days to completely precipitate the irritating substances.S5: Packaging step. Add the paste after removing fire toxins to the tubular shell, and then seal the top of the tubular shell. The tubular shell can be selected as a medical-grade aluminum tube, which needs to comply with the YBB00152002 standard. The filling environment should reach the cleanliness level of 100,000 grades of GMP to complete the inner packaging step. Then, put the outer packaging of the traditional Chinese medicine preparation on the outer shell of the tubular shell. In the packaging step, when adding the paste to the tubular shell, attention should be paid to the hygiene conditions at all times, and the operation needs to be carried out in a sterilized environment. Timely remove the contaminated paste to ensure the thoroughness of sterilization. In the packaging step, when adding the paste to the tubular shell, an automatic paste packaging machine can be used for packaging. A triangular bag paste packaging machine can be selected to finally press the tubular shell into a triangular bag shape.

[0017] The traditional Chinese medicine preparation for treating vitiligo can change the characteristic that its overall use effect is relatively poor during use, can ensure the curative effect of the medicine, avoid toxic and side effects, can conduct local differential treatment through external application, can conduct precise treatment for specific parts, and can effectively treat vitiligo with complex and difficult-to-treat pathogenesis. It can effectively scavenge free radicals, inhibit the expression of AKT and extracellular signal-regulated kinases, and protect against oxidative damage. It can inhibit mast cell histamine and block the nitric oxide melanin signal transduction to regulate the expression of melanocytes. It can sterilize, inhibit bacteria, reduce microbial proliferation, and has the effects of dispelling wind, detoxifying, killing insects, and relieving itching, and can treat the syndrome of wind pathogen and damp toxin congesting the skin.

[0018] The above-mentioned is only the preferred specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and all should be covered within the protection scope of the present invention.

Claims

1. A preparation method of a traditional Chinese medicine preparation for treating vitiligo, characterized in that, The preparation method of the traditional Chinese medicine preparation for treating vitiligo comprises the following steps: S1: Step of selecting traditional Chinese medicinal materials. Firstly, select Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized human hair, Sesamum indicum and Rehmannia glutinosa, and then conduct coarse material treatment. After treatment, set aside. During the calcination process of Pyritum, take pure Pyritum, calcine until it is completely red, immediately put it into vinegar and quench until it becomes brittle. Repeat this process three times. The amount of vinegar used is 30% of the amount of traditional Chinese medicinal materials. After drying, pulverize it; S2: Step of treating medicinal materials. The coarse materials of Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized human hair, Sesamum indicum and Rehmannia glutinosa need to be soaked in sesame oil, and then strictly follow the principle of extending the soaking time in spring and autumn and winter in the ancient method to ensure that the effective components are fully dissolved. Then, control the oil temperature and conduct slow cooking over a gentle fire until the surface of the medicinal materials turns dark brown and the inside turns scorched yellow. Precisely control the temperature for removing the residue and retaining the nature, remove the fire, filter to remove the medicinal residues, and put the filtered medicinal oil back into the refining container; S3: Step of refining oil and forming paste. Raise the refining temperature to 280 - 300 °C. By observing the change of the oil fume, when the phenomenon of green smoke turning into white smoke and the medicinal oil forming beads when dripping water appears, use the method of dripping water to judge whether it is refined. When the medicinal oil shows a light yellow transparent state, take a little and drop it into cold water. When it forms a golden yellow oil bead that sinks to the bottom, at this time, the viscosity of the medicinal oil reaches the best state. Add lead oxide in proportion and stir clockwise at a constant speed until the paste shows a black and bright luster and can be continuously drawn into filaments. Immediately remove the fire and cool down; S4: Step of removing fire toxicity. Firstly, cool the paste after refining to 80 °C and add fine materials to avoid the loss of volatile components caused by high temperature. Then, conduct the treatment of removing fire toxicity. Immerse the finished product in flowing cold water and change the water every day for 7 days to completely precipitate the irritating substances. S5: Packaging step. Add the paste after removing fire toxicity into a tubular shell, and then seal the top of the tubular shell. The tubular shell can be selected as a medical-grade aluminum tube, which needs to meet the YBB00152002 standard. The filling environment reaches a cleanliness of 100,000 levels of GMP to complete the inner packaging step. Then, put the outer packaging of the traditional Chinese medicine preparation on the outer shell of the tubular shell.

2. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the step of selecting traditional Chinese medicinal materials, 3 grams of Caulis Clematidis Armandii, 3 grams of Achyranthes bidentata, 6 grams of Anemarrhena asphodeloides, 6 grams of Saposhnikovia divaricata, 6 grams of Forsythia suspensa, 9 grams of Gardenia jasminoides, 9 grams of Pogostemon cablin, 9 grams of Acorus tatarinowii, 9 grams of Sophora flavescens, 15 grams of Eupatorium fortunei, 15 grams of Pyritum, 15 grams of Carbonized human hair, 15 grams of Sesamum indicum and 15 grams of Rehmannia glutinosa can be selected. The original plant of Caulis Clematidis Armandii is Lardizabalaea biternata (Wall.) Decne. var. australis (Diels) W. T. Wang.

3. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the step of treating medicinal materials, the soaking time in spring and autumn can be 5 days, and the soaking time in winter can be extended to 7 days, and the oil temperature is controlled at 220 °C during the slow cooking stage over a gentle fire.

4. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the step of selecting traditional Chinese medicinal materials, after selecting Caulis Clematidis Armandii, Achyranthes bidentata, Anemarrhena asphodeloides, Saposhnikovia divaricata, Forsythia suspensa, Gardenia jasminoides, Pogostemon cablin, Acorus tatarinowii, Sophora flavescens, Eupatorium fortunei, Pyritum, Carbonized human hair, Sesamum indicum and Rehmannia glutinosa, it is necessary to conduct cleaning, and then drying. During the drying process, charcoal drying can be selected. Compared with open fire, charcoal can provide a more stable temperature and fully preserve the medicinal effect. After drying, grind it into powder and set aside.

5. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the step of selecting the Chinese medicinal materials, when grinding the Chinese medicinal materials of Clematidis Armandii Caulis, Achyranthes Bidentata, Anemarrhenae Rhizoma, Saposhnikoviae Radix, Forsythiae Fructus, Gardeniae Fructus, Pogostemonis Herba, Acori Tatarinowii Rhizoma, Sophorae Flavescentis Radix, Eupatorii Herba, Pyritum, Carbonized Human Hair, Sesami Semen Nigrum, and Rehmanniae Radix Preparata into powder, the methods of cutting, grinding, and pounding can be selected for the step of reshaping the Chinese medicinal materials for use in preparing the paste.

6. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the packaging step, when adding the paste to the tubular shell, attention should be paid to the sanitary conditions at all times, and the operation needs to be carried out in a sterilized environment, and the contaminated paste should be removed in time to ensure the thoroughness of sterilization.

7. The preparation method of a traditional Chinese medicine preparation for treating vitiligo according to claim 1, characterized in that, In the packaging step, when adding the paste to the tubular shell, an automatic paste packaging machine can be used for packaging, and a triangular package paste packaging machine can be selected to finally press the tubular shell into a triangular package shape.