Multi-vitamin microcapsule as well as preparation method and application thereof

Abstract

The invention discloses a multi-vitamin microcapsule as well as a preparation method and application thereof, and belongs to the technical field of medicine manufacturing industry and dietary nutrition supplements. The preparation method comprises the following steps: selecting plant raw materials, and performing extraction, alcohol precipitation, stirring and drying to obtain plant mucus polysaccharide powder; mixing polyglycerol polyricinoleate with sunflower seed oil, adding beta-carotene and vitamin D3, and stirring to obtain an oil phase; dissolving vitamin B1, vitamin B2 and vitamin C in water to obtain a water phase; dissolving the plant mucus polysaccharide powder in water, adding maltodextrin and Arabic gum, and uniformly stirring to obtain a wall material solution; adding the water phase into the oil phase, shearing, mixing with the wall material solution, shearing, homogenizing at high pressure, emulsifying and homogenizing to obtain a homogenized liquid material; and carrying out spray drying to obtain the multi-vitamin microcapsule. The multi-vitamin microcapsule has high encapsulation efficiency and good structural stability, and the stability of vitamins can be remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical fields of pharmaceutical manufacturing and dietary nutritional supplements, and particularly relates to a multi-vitamin microcapsule, a preparation method thereof, and an application thereof. Background Art

[0002] Multi-vitamins, also known as multi-vitamin tablets or multi-element tablets, are nutritional supplements containing multiple vitamins and minerals; for nutritional deficiencies caused by unbalanced diet, poor digestion and absorption, or other reasons, they can be used as supplementary supplements. The composition of multi-vitamins can include vitamin A, vitamin C, vitamin D, vitamin E, B vitamins (including vitamin B1, B2, B6, B12, etc.), folic acid, calcium, iron, zinc, magnesium, etc. Vitamins, as important essential micronutrients for the human body, play a key role in various biochemical reactions. However, the natural content of vitamins is relatively low, and they are easily affected by external factors such as oxidation, heat treatment, and light during production, storage, and processing, resulting in a decrease in their biological activity.

[0003] Microcapsules are a type of micro-container with a polymer or inorganic wall. Existing protein-based microcapsules are sensitive to high temperatures and may denature at high temperatures, leading to the destruction of the microcapsule structure and the leakage of the core material, and they also have a high cost; gum-based microcapsules such as gum arabic or gelatin have disadvantages such as high price, low purity, and limited sources; synthetic polymer-based microcapsules are prone to environmental pollution and are likely to have biocompatibility problems; others such as nano-scale microcapsules are prone to adhesion problems and rupture risks. Therefore, improving the selection of the wall material and the preparation process of microcapsules to improve the encapsulation rate and the integrity of the microcapsule structure is a technical problem that urgently needs to be solved in the existing technology. Summary of the Invention

[0004] Based on the above technical problems to be solved by the present invention, the present invention provides a multi-vitamin microcapsule, a preparation method thereof, and an application thereof. A preparation method of a multi-vitamin microcapsule based on a plant mucopolysaccharide is adopted to prepare a multi-vitamin microcapsule, so as to improve the encapsulation rate and structural stability of vitamins and expand the application of vitamins in food.

[0005] One of the purposes of the present invention is to provide a preparation method of a multi-vitamin microcapsule, which includes the following steps:

[0006] S1. Select cactus, okra, or aloe vera, remove the skin or seeds, perform extraction, alcohol precipitation, stirring, to obtain a gel, collect the gel, and dry it to obtain a plant mucopolysaccharide powder;

[0007] S2. Mix polyglycerol polyricinoleate (PGPR) with sunflower oil, heat it to 55°C to 75°C, stir, cool, add β-carotene, and / or vitamin D3, and stir to obtain an oil phase;

[0008] S3. Dissolve vitamin B1, vitamin B2, and / or vitamin C in water to obtain an aqueous phase;

[0009] S4. Dissolve the plant mucopolysaccharide powder in water, add maltodextrin (MD) and gum arabic (GA), and stir evenly to obtain a wall material solution;

[0010] S5. Add the aqueous phase to the oil phase, shear, mix with the wall material solution, shear, and perform high-pressure homogenization. Through emulsification and homogenization, obtain a homogenized liquid material;

[0011] S6. Spray-dry the homogenized liquid material to obtain multi-vitamin microcapsules.

[0012] Furthermore, the cactus or aloe vera is peeled, and the okra is seeded;

[0013] The volume ratio of the cactus, okra, or aloe vera to the water is 1:1 to 1:4;

[0014] The water is distilled water;

[0015] The extraction time is 24 h;

[0016] For alcohol precipitation, add ethanol with a concentration of more than 75% for precipitation, and collect the white milky gel precipitate; preferably, the ethanol concentration is more than 80%;

[0017] The drying temperature is 20°C to 60°C; the drying time is 12 h to 36 h.

[0018] Furthermore, the mass concentration of polyglycerol polyricinoleate is 1% to 9%;

[0019] The stirring degree is complete dissolution;

[0020] The stirring condition of polyglycerol polyricinoleate and sunflower seed oil is to process at 45°C to 85°C for 10 min to 50 min.

[0021] Furthermore, the mass-to-volume ratio of the mucopolysaccharide is 0.01% to 0.09%; the mass-to-volume ratio of the maltodextrin or the gum arabic is 2% to 10%.

[0022] Furthermore, the mass ratio of water to oil for the preparation of the multi-vitamin microcapsules is 1:9 to 5:5; the core-wall mass ratio is 1:1 to 1:9.

[0023] Furthermore, after the aqueous phase and the oil phase are mixed, the shear with the wall material solution is high-speed shear; the high-speed shear speed is 10,000 r / min to 16,000 r / min, and the treatment time is 1 min to 10 min;

[0024] The aqueous phase, the oil phase, and the wall material solution after high-speed shearing are homogenized at a pressure of 100 bar to 500 bar for 1 minute to 10 minutes.

[0025] Further, the inlet air temperature of the spray drying is 115°C to 125°C, the outlet air temperature is 50°C to 70°C, and the flow rate is 3 mL / min to 10 mL / min.

[0026] Further, the gel is a white emulsion; the drying conditions of the gel are 20°C to 60°C for 12 hours to 36 hours.

[0027] The second object of the present invention is to provide a multivitamin microcapsule, which is prepared according to the preparation method of the multivitamin microcapsule.

[0028] The third object of the present invention is to provide an application of the multivitamin microcapsule in the fields of medicine, feed, or food.

[0029] Compared with the prior art, the present invention provides a multivitamin microcapsule, its preparation method, and its application, and has the following beneficial effects:

[0030] 1. The multivitamin microcapsule proposed by the present invention is based on plant mucopolysaccharide, and the raw materials are selected from natural plants such as cactus, okra, and aloe vera, etc., and has the advantages of being natural, safe, odorless, free of preservatives, and free of fungicides; and plant mucopolysaccharide has stable chemical properties and is not prone to chemical reactions or cross-linking reactions with certain drugs; and plant mucopolysaccharide can encapsulate various types of core materials, including solids, liquids, and gases; plant mucopolysaccharide can precisely control the release rate of the core material and has a good controlled release effect; plant mucopolysaccharide, as a natural polymer material, has a wide source and is renewable, can reduce the dependence on traditional chemical materials, and reduce environmental pollution.

[0031] 2. The multivitamin microcapsule proposed by the present invention deeply explores the ratio of the aqueous phase and the oil phase, overcomes the defects of the double emulsion system emulsifier wall material in the prior art, such as fast drying speed, difficult to completely wrap vitamins, and the prepared microcapsule structure is uneven and incomplete, and proposes a wall material based on plant mucopolysaccharide, and further improves the encapsulation rate and the structural stability of the microcapsule by optimizing the microcapsule preparation process.

[0032] 3. The multivitamin microcapsule prepared by the present invention encapsulates vitamins in nano-scale or micro-scale capsules. The microencapsulation technology can effectively isolate the factors unfavorable to vitamins in the environment, while masking the bad taste of vitamins and realizing their controlled release. Description of the Drawings

[0033] Figure 1Shows the yield diagram of multi - vitamin microcapsules with different wall material compositions in an embodiment of the present invention;

[0034] Figure 2 Shows the water content diagram of multi - vitamin microcapsules with different wall material compositions in an embodiment of the present invention;

[0035] Figure 3 Shows the microscopic structure diagram of multi - vitamin microcapsules with different wall material compositions in an embodiment of the present invention. Detailed implementation manners

[0036] Hereinafter, exemplary embodiments of the present application will be described in more detail with reference to the accompanying drawings. Although the exemplary embodiments of the present application are shown in the drawings, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present application can be more thoroughly understood and the scope of the present application can be fully communicated to those skilled in the art.

[0037] In the following embodiments, unless otherwise specified, the technical means used are conventional means well known to those skilled in the art, and the reagents and materials in the present invention are obtained from the market or other public channels.

[0038] The experimental raw materials and equipment involved in the present invention mainly include but are not limited to:

[0039] Reagents:

[0040] Maltodextrin (Yuanye Bio - technology), sunflower seed oil (Yihai Kerry Golden Arowana), gum arabic powder (Sinopharm Chemical Reagent Co., Ltd.), L(+)-ascorbic acid (99.7%, Sinopharm Chemical Reagent Co., Ltd.), polyglycerol ricinoleate (75%, Shanghai Macklin Biochemical Co., Ltd.), β - carotene (96%, Shanghai Macklin Biochemical Co., Ltd.), vitamin B1 (99%, Jinkelong Beijing Biotechnology Co., Ltd.), vitamin D3 (97%, Jinkelong Beijing Biotechnology Co., Ltd.), riboflavin (Jinkelong Beijing Biotechnology Co., Ltd.);

[0041] Instruments:

[0042] High - speed dispersion homogenizer (FJ200 - SH, Shanghai HuXi Industry Co., Ltd.), high - pressure homogenizer (APV - 2000, Abeeway Far East Equipment Co., Ltd.), small - scale spray dryer (ADL 311, Yamato Scientific Trade (Shanghai) Co., Ltd.), high - performance liquid chromatograph (Model 1100, Agilent Technologies, USA), scanning electron microscope (JEOL 7500F, JEOL Ltd., Japan).

[0043] A multi - vitamin micro - capsule, its preparation method and application according to the present invention use plants such as cactus, okra and aloe as raw materials. Through steps such as peeling or de - seeding, extraction, alcohol precipitation, drying and grinding, plant mucopolysaccharides are prepared. Subsequently, polyglycerol polyricinoleate is mixed with sunflower seed oil and heated to 65 °C for dissolution. After cooling, β - carotene and vitamin D3 are added to form an oil phase. At the same time, vitamin B1, vitamin B2 and vitamin C are dissolved in distilled water to form an aqueous phase. The plant mucopolysaccharide powder is dissolved in distilled water, and maltodextrin and arabic gum are added to form a wall - material solution. The aqueous phase and the oil phase are mixed in proportion, subjected to high - speed shearing, then mixed with the wall - material solution and homogenized under high pressure, and finally multi - vitamin micro - capsules are prepared by spray drying. The multi - vitamin micro - capsules prepared by the method of the present invention have a high encapsulation rate and good structural stability, can significantly improve the stability of vitamins, and expand their application in the food field.

[0044] The technical principle of the present invention mainly includes:

[0045] Through the synergistic effect of plant mucopolysaccharides and PGPR, combined with the formation mechanism of the double - emulsion system, the limitations of traditional micro - capsule technology in terms of encapsulation rate, stability and controlled - release performance are broken through. Plant mucopolysaccharides have a unique high - molecular - chain structure, and their polysaccharide chains are connected by glycosidic bonds to form a network - shaped or branched polymer. This structure endows it with good hydrophilicity and high hydration ability, and can form a stable colloidal solution in the aqueous phase, providing high viscosity and strong rheology for the micro - capsule wall - material. Through the synergistic effect with auxiliary materials such as maltodextrin and arabic gum, plant mucopolysaccharides further enhance the structural stability of the wall - material through intermolecular interactions such as hydrogen bonds and van der Waals forces, effectively preventing the destruction of vitamins by the external environment, and ensuring the efficient encapsulation and controlled release of multi - vitamins. During the emulsification process, PGPR, as an amphiphilic surfactant, plays a key role. Its molecule consists of a hydrophilic polyglycerol chain and a hydrophobic ricinoleic acid chain, and has good emulsification performance. In an aqueous solution, PGPR forms micelles through self - assembly, forms a stable emulsion film at the oil - water interface, reduces the interfacial tension, and ensures the stability of the oil - water phase. In micro - capsule preparation, PGPR not only stabilizes the formation of the basic emulsion, but also plays an important role in the formation of the double - emulsion (O / W / O or W / O / W) structure. By precisely controlling the concentration of PGPR and the emulsification conditions, the stability of the double - emulsion structure is ensured, thus realizing the uniform embedding and controlled release of vitamins.

[0046] Based on the above principle, the present invention provides a multi - vitamin micro - capsule, its preparation method and application, including:

[0047] S1. Wash the cactus, okra and aloe vera clean with distilled water; use a knife to separate the inner pulp of the cactus and aloe vera and slice them. At the same time, remove the seeds of the okra and then slice it; add the above-treated materials to distilled water according to a volume ratio of 1:2, let it stand for 24 hours, then filter them respectively, add 95% (v / v) ethanol according to a volume ratio of 3:1, stir until a white milky gel is formed, collect the gel, dry it and grind it into powder to obtain plant mucopolysaccharide powder;

[0048] S2. Weigh 1-9% (w / w) of PGPR and stir it with sunflower seed oil until dissolved, cool it to room temperature, add β-carotene and vitamin D3, and stir until completely dissolved to obtain an oil phase;

[0049] S3. Dissolve vitamin B1, vitamin B2 and vitamin C in distilled water to obtain an aqueous phase;

[0050] S4. Dissolve the plant mucopolysaccharide powder (0.01-0.09% w / v) in distilled water, add 2-10% (w / v) of MD and GA, and stir evenly to obtain a wall material solution;

[0051] S5. Add the aqueous phase to the oil phase according to a ratio of 1:9 to 5:5, use a high-speed shearer to shear at 13000 r / min for 3 min, then mix it with the wall material solution according to a ratio of 1:1 to 1:9, continue to shear at 10000 r / min for 3 min, and then perform high-pressure homogenization. Through emulsification and homogenization, a homogenized liquid material is obtained;

[0052] S6. Spray-dry the homogenized liquid material at an inlet air temperature of 120 °C, an outlet air temperature of 60 °C and a flow rate of 6 mL / min to obtain multi-vitamin microcapsules.

[0053] For the effect indexes of the multi-vitamin microcapsules, they mainly include the yield, water content and encapsulation rate. The calculation formulas are as follows:

[0054] Yield = mass of microcapsules after spray drying / (total mass of wall material and vitamin core material) × 100%;

[0055] Moisture content on wet basis = (weight of microcapsules before drying - weight of microcapsules after drying) / weight of microcapsules before drying × 100%;

[0056] Encapsulation rate = mass of vitamin core material encapsulated in microcapsules / mass of vitamin core material added in microcapsule preparation × 100%.

[0057] Example 1

[0058] The present invention provides a method for preparing multi-vitamin microcapsules based on cactus mucopolysaccharide.

[0059] It mainly includes:

[0060] (1) Preparation of cactus mucilage polysaccharide: Clean the cactus with distilled water. Use a knife to separate the inner pulp of the cactus and slice it. Add the above-treated material to distilled water at a volume ratio of 1:2 and let it stand for 24 hours, then filter it respectively. Add 95% (v / v) ethanol at a volume ratio of 3:1, stir until a white milky gel is formed, collect the gel, dry it at 40 °C for 24 hours, and then grind it into powder for standby.

[0061] (2) Preparation of microcapsules: Weigh 5% (w / w) of PGPR and mix it with sunflower oil, stir at 65 °C for 30 min until dissolved, add β-carotene and vitamin D3 after cooling, and stir until completely dissolved to obtain the oil phase. Dissolve vitamin B1, vitamin B2 and vitamin C in distilled water to form the water phase. Dissolve the cactus mucilage polysaccharide powder at a concentration of 0.05% (w / v) in distilled water, and add 6% (w / v) of MD and GA, stir evenly to form the wall material solution. Add the water phase to the oil phase at a ratio of 4:6 (v / v), shear at 13000 r / min for 3 min, then mix it with the wall material solution at a ratio of 1:9 (v / v), shear at 10000 r / min for 3 min, and then homogenize it at 300 bar high pressure for 3 min. Feed the mixture into a spray dryer and perform spray drying at an inlet air temperature of 120 °C and an outlet air temperature of 60 °C at a flow rate of 6 mL / min to obtain the multivitamin microcapsules.

[0062] Results: Please refer to Figures 1 to 3 and Table 1. At this time, the yield of the multivitamin microcapsules obtained is 22.48 ± 0.91%, and the water content is 2.11 ± 0.17%. The encapsulation rates of vitamin B1, vitamin B2, vitamin C, β-carotene and vitamin D are 68.50 ± 0.13%, 76.18 ± 0.18%, 84.82 ± 0.19%, 79.29 ± 0.13% and 74.65 ± 0.18% respectively. The microstructure presents a relatively regular spherical shape with wrinkles and depressions on the surface. The above shows that the microcapsules have a high yield, a relatively complete structure, a low water content, and an improved encapsulation rate of multivitamins.

[0063] Example 2

[0064] The present invention provides a method for preparing multivitamin microcapsules based on okra mucilage polysaccharide.

[0065] It mainly includes:

[0066] (1) Preparation of okra mucilage polysaccharide: Wash okra thoroughly with distilled water. Use a knife to remove the seeds and slice the okra. Add the above-treated materials to distilled water at a volume ratio of 1:2 and let stand for 24 hours, then filter separately. Add 95% (v / v) ethanol at a volume ratio of 3:1, stir until a white milky gel is formed, collect the gel, dry it at 40 °C for 24 hours, and then grind it into powder for standby.

[0067] (2) Preparation of microcapsules: Weigh 5% (w / w) of PGPR and mix it with sunflower oil, stir at 65 °C for 30 min until dissolved, add β-carotene and vitamin D3 after cooling, and stir until completely dissolved to obtain the oil phase. Dissolve vitamin B1, vitamin B2, and vitamin C in distilled water to form the water phase. Dissolve the okra mucilage polysaccharide powder at a concentration of 0.05% (w / v) in distilled water, and add 6% (w / v) of MD and GA, stir evenly to form the wall material solution. Add the water phase to the oil phase at a ratio of 4:6 (v / v), shear at 13000 r / min for 3 min, then mix it with the wall material solution at a ratio of 1:9 (v / v), shear at 10000 r / min for 3 min, and then perform high-pressure homogenization at 300 bar for 3 min. Feed the mixture into a spray dryer and perform spray drying at an inlet air temperature of 120 °C and an outlet air temperature of 60 °C at a flow rate of 6 mL / min to obtain the multivitamin microcapsules.

[0068] Results: Please refer to Figures 1 to 3 and Table 1. At this time, the yield of the multivitamin microcapsules obtained is 23.23 ± 0.04%, and the water content is 2.45 ± 0.02%. The encapsulation rates of vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D are 67.22 ± 0.03%, 76.62 ± 0.08%, 84.76 ± 0.15%, 79.20 ± 0.13%, and 75.10 ± 0.27% respectively. The microstructure presents regular spherical shapes with fewer surface wrinkles. The above shows that the microcapsules have a high yield, a complete structure, a low water content, and an improved encapsulation rate of multivitamins.

[0069] Example 3

[0070] The present invention provides a method for preparing multivitamin microcapsules based on aloe mucilage polysaccharide.

[0071] It mainly includes:

[0072] (1) Preparation of aloe mucilage polysaccharide: Wash aloe with distilled water. Use a knife to separate the inner pulp of aloe and slice it. Add the above-treated materials to distilled water at a volume ratio of 1:2 and let it stand for 24 hours, then filter separately. Add 95% (v / v) ethanol at a volume ratio of 3:1, stir until a white milky gel is formed, collect the gel, dry it at 40°C for 24 hours, and then grind it into powder for standby.

[0073] (2) Preparation of microcapsules: Weigh 5% (w / w) of PGPR and mix it with sunflower seed oil, stir at 65°C for 30 min until dissolved, add β-carotene and vitamin D3 after cooling, and stir until completely dissolved to obtain the oil phase. Dissolve vitamin B1, vitamin B2, and vitamin C in distilled water to form the water phase. Dissolve aloe mucilage polysaccharide powder at a concentration of 0.05% (w / v) in distilled water, and add 6% (w / v) of MD and GA, stir evenly to form the wall material solution. Add the water phase to the oil phase at a ratio of 4:6 (v / v), shear at 13000 r / min for 3 min, then mix it with the wall material solution at a ratio of 1:9 (v / v), shear at 10000 r / min for 3 min, and then perform high-pressure homogenization at 300 bar for 3 min. Feed the mixture into a spray dryer and perform spray drying at an inlet air temperature of 120°C and an outlet air temperature of 60°C at a flow rate of 6 mL / min to obtain the multivitamin microcapsules.

[0074] Results: Please refer to Figures 1 to 3 and Table 1. At this time, the yield of the multivitamin microcapsules obtained is 25.09 ± 0.10%, and the water content is 2.25 ± 0.22%. The encapsulation rates of vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D are 72.82 ± 0.49%, 82.96 ± 0.05%, 88.58 ± 0.05%, 79.34 ± 0.08%, and 89.29 ± 0.04% respectively. The microstructure presents regular spherical shapes with a smooth and tight surface. The above indicates that the microcapsules have a complete and stable structure, a high yield, a low water content, and an improved encapsulation rate of multivitamins.

[0075] Comparative Example

[0076] The present invention proposes a comparative experiment on emulsifiers (wall materials) of different types of double emulsion systems.

[0077] It mainly includes:

[0078] The preparation method of Comparative Example 1 is the same as that of Example 1. During the preparation, the oil phase, water phase, water-oil mass ratio, core-wall mass ratio, and homogenization conditions remain unchanged, and the drying method is spray drying. The only difference is that the wall material solution is 6% (w / v) MD and GA dissolved in distilled water together.

[0079] Results: Please refer toFigures 1 to 3 And Table 1. At this time, the yield of the multivitamin microcapsules obtained was 17.48 ± 0.41%, and the water content was 4.02 ± 0.04%. The encapsulation rates of vitamin B1, vitamin B2, vitamin C, β-carotene, and vitamin D were 67.75 ± 0.09%, 74.55 ± 0.43%, 83.34 ± 0.10%, 79.43 ± 0.12%, and 71.97 ± 0.18%, respectively. The microstructure presented relatively regular spherical shapes, with a rough and wrinkled surface. The above indicates that the yield of the microcapsules was low, the water content was high, the encapsulation rate was low, and the particle integrity was poor.

[0080] Table 1 Encapsulation Rates of Vitamins in Multivitamin Microcapsules with Different Wall Material Compositions

[0081]

[0082] Note: The same letter in the same column represents no significant difference (p > 0.05).

[0083] Currently, for the co - encapsulation of various vitamins such as fat - soluble and water - soluble vitamins, the double - emulsion system (such as W / O / W emulsion) combined with spray - drying technology is the most commonly used method for preparing microcapsules. However, in practical applications, due to the relatively fast drying speed of the emulsifier (wall material) in the double - emulsion system, it is difficult to completely encapsulate vitamins, resulting in an uneven or incomplete structure of the prepared microcapsules. In addition, due to the poor chemical stability of vitamins themselves, these factors may lead to poor protection effect of microcapsules on vitamins during the spray - drying process or storage, and the slow - release performance is also not ideal.

[0084] It should be noted that the term "comprising" or any other variant thereof is intended to cover non - exclusive inclusion, such that a process, method, article, or device comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or elements that are inherent to such process, method, article, or device. Without further limitation, the elements defined by the statement "comprising..." do not exclude the presence of additional identical elements in the process, method, article, or device comprising the said elements.

[0085] The above are only examples of the present application and are not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the scope of the claims of the present application.

Claims

1. A method for preparing a multivitamin microcapsule, characterized in that, It includes the following steps: S1. Select cactus, okra or aloe, peel or remove seeds, extract, precipitate with alcohol, stir, obtain gel, collect the gel, and dry to obtain plant mucopolysaccharide powder; S2. Mix polyglyceryl polyricinoleate with sunflower seed oil, heat to 55°C - 75°C, stir, cool, add β-carotene, and / or vitamin D3, and stir to obtain an oil phase; S3. Dissolve vitamin B1, vitamin B2, and / or vitamin C in water to obtain an aqueous phase; S4. Dissolve the plant mucopolysaccharide powder in water, add maltodextrin and arabic gum, and stir evenly to obtain a wall material solution; S5. Add the aqueous phase to the oil phase, shear, mix with the wall material solution, shear, and perform high-pressure homogenization. Through emulsification and homogenization, obtain a homogenized liquid material; S6. Spray-dry the homogenized liquid material to obtain multi-vitamin microcapsules.

2. The preparation method of the multivitamin microcapsule according to claim 1, wherein, The cactus or aloe is peeled, and the okra is seed-removed; The volume ratio of the cactus, okra or aloe to the water is 1:1 - 1:4; The water is distilled water; The extraction time is 24 h; The alcohol precipitation is to add ethanol with a concentration of more than 75% for precipitation, and collect the white milky gel precipitate; preferably, the ethanol concentration is more than 80%; The drying temperature is 20°C - 60°C; the drying time is 12 h - 36 h.

3. The preparation method of the multivitamin microcapsule according to claim 1, characterized in that, The mass concentration of the polyglyceryl polyricinoleate is 1% - 9%; The stirring degree is complete dissolution; The stirring condition of the polyglyceryl polyricinoleate and sunflower seed oil is to process at 45°C - 85°C for 10 min - 50 min.

4. The preparation method of the multivitamin microcapsule according to claim 1, characterized in that, The mass-volume ratio of the mucopolysaccharide is 0.01% - 0.09%; the mass-volume ratio of the maltodextrin or the arabic gum is 2% - 10%.

5. The preparation method of the multivitamin microcapsule according to claim 1, wherein, The water-oil mass ratio for the preparation of the multi-vitamin microcapsules is 1:9 - 5:5; the core-wall mass ratio is 1:1 - 1:

9.

6. The preparation method of the multivitamin microcapsule according to claim 1, characterized in that After the aqueous phase and the oil phase are mixed, the shear with the wall material solution is high-speed shear; the high-speed shear speed is 10000 r / min - 16000 r / min, and the treatment time is 1 min - 10 min; The aqueous phase, the oil phase and the wall material solution after the high-speed shear treatment are homogenized at a pressure of 100 bar - 500 bar for 1 min - 10 min.

7. The preparation method of the multivitamin microcapsule according to claim 1, characterized in that The inlet air temperature of the spray drying is 115°C - 125°C, the outlet air temperature is 50°C - 70°C, and the flow rate is 3 mL / min - 10 mL / min.

8. The preparation method of the multivitamin microcapsule according to claim 1, characterized in that, The gel drying condition is 20°C - 60°C, and it is processed for 12 h - 36 h.

9. A multi-vitamin microcapsule, characterized in that, The multi-vitamin microcapsules are prepared according to the preparation method of the multi-vitamin microcapsules described in any one of claims 1 - 8.

10. The application of the multi-vitamin microcapsules according to claim 9 in the fields of medicine, feed or food.

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