Composite VC skin whitening and brightening dressing, preparation method thereof and application of cosmetic

Abstract

The invention discloses a composite VC skin whitening and brightening dressing, a preparation method thereof and application of cosmetics. The dressing comprises a supporting body and a gel layer located on the surface of the supporting body. The gel layer comprises a first gel sub-layer and a second gel sub-layer which are arranged on the surface of the supporting body in a stacked mode. The first gel sub-layer comprises a first hydrogel base material and an ascorbic acid derivative located in the first hydrogel base material, and the second gel sub-layer comprises a second hydrogel base material and ergothioneine located in the second hydrogel base material. The ascorbic acid derivative comprises at least one of magnesium ascorbyl phosphate, sodium ascorbyl phosphate, 3-o-ethyl ascorbic acid, ascorbic acid polypeptide and ascorbic acid glucoside. Wherein the mass ratio of the ascorbic acid derivative to the ergothioneine is (1-250): 1. The dressing can effectively solve the possible problems of long onset time of ergothioneine and possible skin sensitivity of ascorbic acid derivatives.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and particularly to a compound VC whitening and brightening dressing and its preparation method and application in cosmetics. Background Art

[0002] With the increasing attention of people to skin beauty, whitening and brightening have become a popular demand in the skin care field. Skin pigmentation problems such as freckles and melasma not only affect beauty but may also bring psychological pressure to users. At present, there are various whitening ingredients used in the research and development of related products, but each has certain limitations. Developing a whitening product that can not only take effect quickly but also ensure mildness and efficiently solve the problem of skin pigment deposition has important practical significance. Summary of the Invention

[0003] Based on the above problems, the present invention provides a compound VC whitening and brightening dressing and its preparation method and application in cosmetics. The compound VC whitening and brightening dressing can effectively promote the improvement of the repair effect of local skin pigment deposition.

[0004] To achieve the above object, the present invention adopts the following technical solutions:

[0005] A compound VC whitening and brightening dressing, comprising a support body and a gel layer located on the surface of the support body. The gel layer includes a first gel sub-layer and a second gel sub-layer stacked on the surface of the support body, and the second gel sub-layer is closer to the application surface of the compound VC whitening and brightening dressing than the first gel sub-layer; the first gel sub-layer includes a first hydrogel substrate and ascorbic acid derivatives located in the first hydrogel substrate, the second gel sub-layer includes a second hydrogel substrate and ergothioneine located in the second hydrogel substrate, the ascorbic acid derivatives include at least one of magnesium ascorbyl phosphate, sodium ascorbyl phosphate, 3 - O - ethyl ascorbic acid, ascorbic acid polypeptide, and ascorbyl glucoside, and the mass ratio of the ascorbic acid derivatives to the ergothioneine is (1 - 250):1.

[0006] Optionally, the mass ratio of the ascorbic acid derivatives to the ergothioneine is (10 - 100):1.

[0007] Optionally, the mass percentage of the ascorbic acid derivatives in the first gel sub-layer is 5% - 80%.

[0008] Optionally, the mass percentage of the ergothioneine in the second gel sub-layer is 0.5% - 10%.

[0009] Optionally, the thickness of the first gel sub-layer is 1 mm - 2 mm.

[0010] Optionally, the thickness of the second gel sub-layer is 0.2 mm - 0.8 mm.

[0011] Optionally, the first hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel; the second hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel.

[0012] The preparation method of the above composite VC whitening and brightening dressing includes the following steps:

[0013] Disperse the ascorbic acid derivative in the raw materials of the first hydrogel substrate to obtain a first slurry;

[0014] Coat the first slurry on the surface of the support and perform first crosslinking and curing to form the first gel sub-layer on the surface of the support;

[0015] Disperse the ergothioneine in the raw materials of the second hydrogel substrate to obtain a second slurry;

[0016] Coat the second slurry on the surface of the first gel sub-layer and perform second crosslinking and curing to form the second gel sub-layer on the surface of the first gel sub-layer.

[0017] Optionally, the temperature of the first crosslinking and curing is 40°C - 60°C, and the time of the first crosslinking and curing is 10 min - 30 min; the temperature of the second crosslinking and curing is 35°C - 55°C, and the time of the second crosslinking and curing is 15 min - 25 min.

[0018] The application of the above composite VC whitening and brightening dressing in cosmetics is to make the composite VC whitening and brightening dressing into cosmetics.

[0019] Beneficial effects

[0020] In the composite VC whitening and brightening dressing of the present invention, by setting the ascorbic acid derivative and ergothioneine adaptively and introducing the first hydrogel substrate and the second hydrogel substrate, the functions of the ascorbic acid derivative and ergothioneine can be fully exerted, and at the same time, the problems of long onset time that may exist in ergothioneine and skin sensitivity that may exist in the ascorbic acid derivative can be solved, thereby effectively promoting the improvement of the repair effect of local skin pigment deposition. Detailed implementation manners

[0021] An embodiment of the present invention provides a composite VC whitening and brightening dressing, which includes a support body and a gel layer located on the surface of the support body. The gel layer includes a first gel sub-layer and a second gel sub-layer stacked on the surface of the support body, and the second gel sub-layer is closer to the application surface of the composite VC whitening and brightening dressing than the first gel sub-layer; the first gel sub-layer includes a first hydrogel substrate and ascorbic acid derivatives (VC) located in the first hydrogel substrate, and the second gel sub-layer includes a second hydrogel substrate and ergothioneine located in the second hydrogel substrate. The ascorbic acid derivatives include at least one of magnesium ascorbyl phosphate, sodium ascorbyl phosphate, 3-O-ethyl ascorbic acid, ascorbic acid polypeptide, and ascorbyl glucoside. The mass ratio of the ascorbic acid derivatives to ergothioneine is (1-250):1.

[0022] In the exploration of the combination of common cosmetic raw materials by the inventors of the present invention, it was found that although ascorbic acid derivatives and ergothioneine have good effects on whitening and brightening the skin, there are also some problems with them. For example, ascorbic acid derivatives, as common whitening ingredients, have the effects of reducing melanin and inhibiting the activity of tyrosinase, thereby achieving a whitening effect. However, ascorbic acid derivatives are prone to cause skin sensitivity problems during use, which limits their wide application. Ergothioneine is a natural antioxidant that can effectively resist the damage of free radicals to the skin, reduce pigment production from the source, and has good whitening potential. However, ergothioneine has the disadvantage of relatively slow onset, and it is difficult for users to significantly perceive the whitening and brightening effect in the short term, which frustrates the patience of consumers.

[0023] In the composite VC whitening and brightening dressing of the present invention, ascorbic acid derivatives and ergothioneine are combined with the hydrogel substrate to obtain the first gel sub-layer and the second gel sub-layer respectively, and the second gel sub-layer is closer to the application surface of the composite VC whitening and brightening dressing than the first gel sub-layer. The hydrogel substrate can play a role in promoting the dispersion of ascorbic acid derivatives and ergothioneine, which is beneficial for ascorbic acid derivatives and ergothioneine to each exert their excellent properties. More importantly, when using this dressing, ergothioneine first contacts the skin and initially exerts an antioxidant effect, providing a protective barrier for the skin. Then, the ascorbic acid derivatives in the second gel sub-layer can be supplemented into the first gel sub-layer to further exert the whitening and brightening effect. In this process, the protective barrier effect formed by the action of ergothioneine can effectively reduce the skin sensitivity effect that ascorbic acid derivatives may cause. At the same time, due to the fitting effect of the first hydrogel substrate in the first hydrogel sub-layer and the skin, when the dressing contacts the skin, ergothioneine can be quickly transferred to the skin surface and quickly exert the barrier protection effect, thereby effectively improving the onset speed of ergothioneine.

[0024] In addition, the mass ratio of the ascorbic acid derivative to ergothioneine is (1 - 250):1. That is, the mass of the ascorbic acid derivative is greater than or equal to that of ergothioneine, which can promote the penetration of the ascorbic acid derivative into the second gel sub-layer and further accelerate the onset time of the composite VC whitening and brightening dressing.

[0025] Therefore, the composite VC whitening and brightening dressing of the present invention can give full play to the roles of the ascorbic acid derivative and ergothioneine, and at the same time solve the problems of the long onset time that may exist in ergothioneine and the skin sensitivity problem that may exist in the ascorbic acid derivative, thereby effectively promoting the improvement of the repair effect of local skin pigment deposition.

[0026] It can be understood that the application surface of the composite VC whitening and brightening dressing is the surface for contacting the skin.

[0027] Optionally, the mass ratio of the ascorbic acid derivative to ergothioneine can be 1:1, 5:1, 10:1, 20:1, 30:1, 50:1, 80:1, 100:1, 150:1, 200:1, 250:1, etc. Further optionally, the mass ratio of the ascorbic acid derivative to ergothioneine is (10 - 100):1.

[0028] In some embodiments, the mass percentage of the ascorbic acid derivative in the first gel sub-layer is 5% - 80%. For example, the mass percentage of the ascorbic acid derivative in the first gel sub-layer can be 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, etc. It can be understood that the mass percentage of the ascorbic acid derivative in the first gel sub-layer can also be other suitable selections within the range of 5% - 80%.

[0029] In some embodiments, the mass percentage of ergothioneine in the second gel sub-layer is 0.5% - 10%. For example, the mass percentage of ergothioneine in the second gel sub-layer can be 0.5%, 1%, 2%, 5%, 8%, 10%, etc. It can be understood that the mass percentage of ergothioneine in the second gel sub-layer can also be other suitable selections within the range of 0.5% - 10%.

[0030] Optionally, the mass percentage of the ascorbic acid derivative in the first gel sub-layer is greater than the mass percentage of ergothioneine in the second gel sub-layer.

[0031] In some embodiments, the thickness of the first gel sub-layer is 1 mm - 2 mm. Optionally, the thickness of the first gel sub-layer can be 1 mm, 1.2 mm, 1.3 mm, 1.5 mm, 1.8 mm, 2 mm, etc. Further optionally, the thickness of the first gel sub-layer can also be other suitable selections within the range of 1 mm - 2 mm.

[0032] In some embodiments, the thickness of the second gel sub-layer is 0.2 mm - 0.8 mm. Optionally, the thickness of the second gel sub-layer can be 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, etc. It can be understood that other suitable selections can also be made for the thickness of the second gel sub-layer within the range of 0.2 mm - 0.8 mm.

[0033] In some embodiments, the first hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel. The second hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel.

[0034] In some embodiments, the composite VC whitening and brightening dressing further includes a protective film. The protective film is located on the fitting surface. The material of the protective film includes one or more of polyethylene and polypropylene. It can be understood that when using the dressing, the protective film is removed, and then the fitting surface is brought into contact with the skin. The protective film can prevent the fitting surface of the composite VC whitening and brightening dressing from being contaminated.

[0035] In some embodiments, the support is one of non-woven fabric, silk fabric, or polyurethane film.

[0036] Another embodiment of the present invention provides a preparation method of the above-mentioned composite VC whitening and brightening dressing, including the following steps: dispersing ascorbic acid derivatives in the raw materials of the first hydrogel substrate to obtain a first slurry. Coating the first slurry on the surface of the support and performing first crosslinking and curing to form a first gel sub-layer on the surface of the support. Dispensing ergothioneine in the raw materials of the second hydrogel substrate to obtain a second slurry. Coating the second slurry on the surface of the first gel sub-layer and performing second crosslinking and curing to form a second gel sub-layer on the surface of the first gel sub-layer.

[0037] Optionally, the temperature of the first crosslinking and curing is 40°C - 60°C. For example, the temperature of the first crosslinking and curing can be 40°C, 45°C, 50°C, 55°C, 60°C, etc. Further optionally, other suitable selections can also be made for the temperature of the first crosslinking and curing within the range of 40°C - 60°C.

[0038] Optionally, the time of the first crosslinking and curing is 10 min - 30 min. For example, the time of the first crosslinking and curing can be 10 min, 15 min, 20 min, 25 min, 30 min, etc. Further optionally, other suitable selections can also be made for the time of the first crosslinking and curing within the range of 10 min - 30 min.

[0039] Optionally, the temperature of the second crosslinking and curing is 35°C - 55°C. For example, the temperature of the second crosslinking and curing can be 35°C, 40°C, 45°C, 50°C, 55°C, etc. Further optionally, other suitable selections can also be made within the range of 35°C - 55°C for the temperature of the second crosslinking and curing.

[0040] Optionally, the time of the second crosslinking and curing is 15 min - 25 min. For example, the time of the second crosslinking and curing can be 15 min, 20 min, 25 min, etc. Further optionally, other suitable selections can also be made within the range of 15 min - 25 min for the time of the second crosslinking and curing.

[0041] Optionally, the crosslinking agents used for the first crosslinking and curing and the second crosslinking and curing can be independently selected from calcium chloride, glutaraldehyde, etc.

[0042] Another embodiment of the present invention provides an application of the above-mentioned composite VC whitening and brightening dressing in cosmetics, and this application lies in making the composite VC whitening and brightening dressing into cosmetics.

[0043] Another embodiment of the present invention provides a cosmetic, and this cosmetic includes the above-mentioned composite VC whitening and brightening dressing. Optionally, the cosmetic includes a facial mask or a patch.

[0044] Example 1

[0045] In this example, the composite VC whitening and brightening dressing includes a non-woven support and a gel layer on the surface of the support. The gel layer includes a first gel sub-layer and a second gel sub-layer laminated on the surface of the support, and the second gel sub-layer is closer to the application surface of the composite VC whitening and brightening dressing than the first gel sub-layer; the first gel sub-layer includes a sodium alginate hydrogel substrate and magnesium ascorbyl phosphate in the sodium alginate hydrogel substrate, and the second gel sub-layer includes a sodium alginate hydrogel substrate and ergothioneine in the sodium alginate hydrogel substrate. The mass ratio of the ascorbic acid derivative to ergothioneine is 1:1. The mass percentage of magnesium ascorbyl phosphate in the first gel sub-layer is 20%. The mass percentage of ergothioneine in the second gel sub-layer is 5%. The thickness of the first gel sub-layer is 2 mm. The thickness of the second gel sub-layer is 0.5 mm.

[0046] Example 2

[0047] Compared with Example 1, the difference in Example 2 is that: the mass ratio of the ascorbic acid derivative to ergothioneine is 10:1.

[0048] Example 3

[0049] Compared with Example 1, the difference in Example 3 is that: the mass ratio of the ascorbic acid derivative to ergothioneine is 50:1.

[0050] Example 4

[0051] Compared with Example 1, Example 4 is different in that the mass ratio of ascorbic acid derivative to ergothioneine is 100:1.

[0052] Example 5

[0053] Compared with Example 1, Example 5 is different in that the mass ratio of ascorbic acid derivative to ergothioneine is 250:1.

[0054] Comparative Example 1

[0055] Compared with Example 1, Comparative Example 1 is different in that the mass ratio of ascorbic acid derivative to ergothioneine is 0.5:1.

[0056] Comparative Example 2

[0057] Compared with Example 1, Comparative Example 2 is different in that the mass ratio of ascorbic acid derivative to ergothioneine is 300:1.

[0058] Comparative Example 3

[0059] Compared with Example 1, Comparative Example 3 is different in that magnesium ascorbyl phosphate is replaced with an equal mass of ergothioneine.

[0060] Comparative Example 4

[0061] Compared with Example 1, Comparative Example 4 is different in that ergothioneine is replaced with an equal mass of magnesium ascorbyl phosphate.

[0062] Test Example

[0063] Test subjects: 90 volunteers aged 25 - 45 with moderate melasma or freckles and other pigmentation problems on the face, randomly divided into 9 groups, with 10 people in each group, 5 males and 5 females.

[0064] The dressings of the examples and comparative examples were used for the 9 groups of volunteers respectively.

[0065] Before the test began, the initial skin chromaticity of the test area on the face of all volunteers (selecting the cheek area where the skin spots are more concentrated, with an area of about 4 cm 2 ) was measured using a skin chromaticity detection instrument. The chromaticity of the same position was measured again after 15 minutes of use. Calculate the change rate of the chromaticity value △L = (L2 - L1) / L1 × 100%, where L1 is the skin brightness value before the test and L2 is the skin brightness value after the dressing is used.

[0066] The average value of each group was taken as the test value. The test results are shown in Table 1.

[0067]

[0068]

[0069] In addition, the test results show that only slight swelling occurred at the test site of the volunteer in Comparative Example 4.

[0070] As can be seen from Table 1, the dressings in the examples have better whitening effects. Compared with Comparative Example 3, the whitening effect of the examples is better than that of Comparative Example 3, indicating that the onset time of the examples is faster. Only slight swelling occurred in Comparative Example 4, indicating that the dressings in the examples can effectively solve the possible skin sensitivity problem of ascorbic acid derivatives. That is, the dressings of the present invention can preferably solve the problems of long onset time of ergothioneine and possible skin sensitivity of ascorbic acid derivatives.

[0071] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

[0072] For those of ordinary skill in the art, according to the idea of the present invention, there will be changes in the specific implementation manners and application scopes. In summary, the content of this specification should not be construed as a limitation to the present invention.

Claims

1. A compound VC whitening and brightening dressing, characterized in that It includes a support body and a gel layer located on the surface of the support body. The gel layer includes a first gel sub-layer and a second gel sub-layer stacked on the surface of the support body. The second gel sub-layer is closer to the application surface of the composite VC whitening and brightening dressing than the first gel sub-layer; the first gel sub-layer includes a first hydrogel substrate and ascorbic acid derivatives located in the first hydrogel substrate, and the second gel sub-layer includes a second hydrogel substrate and ergothioneine located in the second hydrogel substrate. The ascorbic acid derivatives include at least one of magnesium ascorbyl phosphate, sodium ascorbyl phosphate, 3-O-ethyl ascorbic acid, ascorbic acid polypeptide, and ascorbyl glucoside. The mass ratio of the ascorbic acid derivatives to the ergothioneine is (1-250):

1.

2. The composite VC whitening and brightening dressing according to claim 1, characterized in that, The mass ratio of the ascorbic acid derivatives to the ergothioneine is (10-100):

1.

3. The composite VC whitening and brightening dressing according to claim 1, characterized in that, The mass percentage of the ascorbic acid derivatives in the first gel sub-layer is 5%-80%.

4. The composite VC whitening and brightening dressing according to claim 1, wherein, The mass percentage of the ergothioneine in the second gel sub-layer is 0.5%-10%.

5. The composite VC whitening and brightening dressing according to claim 1, wherein The thickness of the first gel sub-layer is 1 mm-2 mm.

6. The composite VC whitening and brightening dressing according to claim 1, wherein The thickness of the second gel sub-layer is 0.2 mm-0.8 mm.

7. The composite VC whitening and brightening dressing according to any one of claims 1-6, characterized in that The first hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel; the second hydrogel substrate includes at least one of polyacrylic acid hydrogel, polyvinyl alcohol hydrogel, carrageenan hydrogel, and sodium alginate hydrogel.

8. The preparation method of the composite VC whitening and brightening dressing according to any one of claims 1-7, characterized in that, It includes the following steps: Disperse the ascorbic acid derivatives in the raw materials of the first hydrogel substrate to obtain a first slurry. Coat the first slurry on the surface of the support body and perform first cross-linking and curing to form the first gel sub-layer on the surface of the support body. Disperse the ergothioneine in the raw materials of the second hydrogel substrate to obtain a second slurry. Coat the second slurry on the surface of the first gel sub-layer and perform second cross-linking and curing to form the second gel sub-layer on the surface of the first gel sub-layer.

9. The preparation method of the composite VC whitening and brightening dressing according to claim 8, characterized in that, The temperature of the first cross-linking and curing is 40°C-60°C, and the time of the first cross-linking and curing is 10 min-30 min; the temperature of the second cross-linking and curing is 35°C-55°C, and the time of the second cross-linking and curing is 15 min-25 min.

10. Use of the composite VC whitening and brightening dressing according to any one of claims 1-7 in cosmetics, characterized in that, Make the composite VC whitening and brightening dressing into cosmetics.

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