Bionic sebum composition with soothing effect and preparation method

Abstract

The invention relates to the technical field of infant cosmetics, in particular to a bionic sebum composition as well as a preparation method and application thereof. The bionic sebum composition disclosed by the invention is prepared from vegetable oil compounded cetostearyl alcohol, beewax, jojoba esters, hydrogenated lecithin, phytosterol, synthetic squalane, VE acetate, a purslane extract, a raspberry fruit extract and ceramide, wherein the vegetable oil comprises shea butter, olive oil and flat-core wood oil. The bionic sebum composition provided by the invention has good skin-friendly property and absorption speed, and is high in bioavailability; the soothing function is achieved, and irritation is avoided; all the components interact with one another, so that rapid fusion with a sebum film in the use process is facilitated, a protective barrier is formed, the antibacterial ability is high, and a good protective effect can be provided for infant skin.

Description

Technical Field

[0001] The present invention relates to the technical field of baby cosmetics, and particularly relates to a biomimetic sebum composition with a soothing effect and a preparation method thereof. Background Art

[0002] The skin and cutin layer structure of infants are thinner than those of adults, the sebaceous gland activity is inactive, and the secreted sebum is relatively less, so the skin antibacterial ability is poor. At present, the oil-phase components of baby cosmetics are mostly chemical oils, and insufficient consideration is given to the skin-friendly property and the composition structure of the oils, resulting in poor skin-friendly property, slow absorption speed, and low bioavailability. At the same time, there are few targeted soothing components in the oil phase of current baby cosmetics, and the irritation is obvious when used by infants.

[0003] In view of this, the present invention is specifically proposed. Summary of the Invention

[0004] The present invention provides a biomimetic sebum composition, a preparation method and an application thereof. The biomimetic sebum composition is added with more plant soothing components, is suitable for infants to use, and has a good repair and protection effect.

[0005] Specifically, the technical solution provided by the present invention is as follows:

[0006] In the first aspect, the present invention provides a biomimetic sebum composition, which comprises the following components in parts by mass: shea butter 10 - 30 parts, olive oil 30 - 60 parts, pittosporum oil 1 - 10 parts, cetearyl alcohol 10 - 30 parts, beeswax 1 - 10 parts, jojoba esters 1 - 20 parts, hydrogenated lecithin 0.1 - 5 parts, phytosterols 1 - 20 parts, synthetic squalane 1 - 10 parts, VE acetate 0.1 - 5 parts, purslane extract 0.1 - 5 parts, raspberry fruit extract 0.1 - 5 parts, and ceramide 0.1 - 5 parts.

[0007] The components of human sebum are relatively complex, mainly containing wax esters (~25%), triglycerides (~55 - 60%), free fatty acids (~30%), and also mixed with phospholipids, cholesterol esters, squalene (~10%) and the like produced after the metabolism of epithelial cells. The biomimetic sebum composition provided by the present invention takes vegetable oil as the main component. The vegetable oil contains a large amount of fatty acid components, including saturated and unsaturated fatty acids, such as stearic acid, palmitic acid, linoleic acid, linolenic acid, etc., which can react with other components contained in the composition, such as fatty alcohols, triglycerides, etc. Then, combined with synthetic squalane, it can improve the skin affinity and permeability of the product, and further help to quickly blend with the sebum film during use to form a protective barrier. The vegetable oil in the present invention is selected from shea butter, olive oil and pittosporum oil, and it is compounded with components such as cetearyl alcohol, beeswax, jojoba esters, hydrogenated lecithin, phytosterols, synthetic squalane, ceramides, VE acetate, etc. to simulate human sebum and has characteristics similar to human sebum. At the same time, the present invention also adds portulaca oleracea extract and raspberry fruit extract components, which have a good soothing effect on damaged skin.

[0008] Preferably, by mass percentage, the biomimetic sebum composition comprises: shea butter 10 - 30%, olive oil 30 - 60%, pittosporum oil 1 - 10%, cetearyl alcohol 10 - 30%, beeswax 1 - 10%, jojoba esters 1 - 20%, hydrogenated lecithin 0.1 - 5%, phytosterols 1 - 20%, synthetic squalane 1 - 10%, VE acetate 0.1 - 5%, portulaca oleracea extract 0.1 - 5%, raspberry fruit extract 0.1 - 5%, ceramides 0.1 - 5%.

[0009] More preferably, by mass percentage, the biomimetic sebum composition comprises: shea butter 15 - 30%, olive oil 40 - 60%, pittosporum oil 1 - 10%, cetearyl alcohol 10 - 20%, beeswax 1 - 5%, jojoba esters 1 - 10%, hydrogenated lecithin 1 - 5%, phytosterols 1 - 10%, synthetic squalane 1 - 5%, VE acetate 0.1 - 2%, portulaca oleracea extract 0.1 - 3%, raspberry extract 0.1 - 3%, ceramides 0.1 - 3%.

[0010] More preferably, by mass percentage, the biomimetic sebum composition comprises: shea butter 10 - 20%, olive oil 40 - 50%, pittosporum oil 1 - 5%, cetearyl alcohol 10 - 15%, beeswax 1 - 3%, jojoba esters 1 - 8%, hydrogenated lecithin 1 - 3%, phytosterols 1 - 5%, synthetic squalane 1 - 3%, VE acetate 0.1 - 1%, portulaca oleracea extract 0.1 - 1%, raspberry fruit extract 0.1 - 1%, ceramides 0.1 - 3%.

[0011] The bionic sebum composition obtained by the preferred solution of the present invention has relatively better skin-friendly properties and absorption rate, high bioavailability; has a soothing function, is non-irritating, can provide good protection for the skin of infants and young children, and has a good antibacterial effect.

[0012] The present invention does not particularly limit the sources of each component, and any conventional commercially available sources in the art can be used.

[0013] In a second aspect, the present invention provides a preparation method of the bionic sebum composition, comprising the following steps: adding each raw material into a stirring kettle in the order of shea butter, olive oil, pittosporum oil, cetearyl alcohol, beeswax, jojoba esters, hydrogenated lecithin, phytosterols, synthetic squalane, VE acetate, purslane extract, raspberry fruit extract, and ceramide, gradually heating up, and continuously stirring until all raw materials are dissolved and the raw material mixture is homogeneous and transparent.

[0014] Among them, the maximum temperature during the heating process shall not exceed 60 °C.

[0015] Preferably, the present invention heats up the mixed materials to 50 °C at a heating rate of not more than 3 °C per minute, stops heating, and continuously stirs at a rate of 60-80 r / min to obtain the bionic sebum composition.

[0016] The preparation method provided by the present invention has a simple process and low cost, and is suitable for industrial production.

[0017] In a third aspect, the present invention provides an application of the bionic sebum composition in the preparation of cosmetics for infants and young children; preferably, the cosmetics include skin care products.

[0018] In a fourth aspect, the present invention provides an application of the bionic sebum composition in soothing the skin for non-therapeutic purposes.

[0019] For example, after bathing infants and young children, due to the imperfect skin barrier of infants, it is easy to lose water and cause dryness and flushing; or skin flushing caused by eczema or other inflammatory stimuli.

[0020] In a fifth aspect, the present invention provides a cosmetic, and the cosmetic contains the bionic sebum composition. Based on the good skin-friendly properties and bioavailability of the bionic sebum composition, the cosmetic containing the bionic sebum composition has similar functions and effects.

[0021] Beneficial effects:

[0022] The present invention provides a bionic sebum composition, a preparation method and an application thereof. The bionic sebum composition comprises the following components in parts by mass: 10-30 parts of shea butter, 30-60 parts of olive oil, 1-10 parts of Prinsepia utilis Royle oil, 10-30 parts of cetearyl alcohol, 1-10 parts of beeswax, 1-20 parts of jojoba esters, 0.1-5 parts of hydrogenated lecithin, 1-20 parts of phytosterols, 1-10 parts of synthetic squalane, 0.1-5 parts of VE acetate, 0.1-5 parts of Portulaca oleracea extract, 0.1-5 parts of raspberry fruit extract and 0.1-5 parts of ceramide. The bionic sebum composition provided by the present invention has good skin affinity and absorption rate, and high bioavailability; has a soothing function and no irritation; the components interact with each other, which helps to quickly blend with the sebum film during use to form a protective barrier, and can provide good protection for the skin of infants and young children. Detailed Embodiments

[0023] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions in the present invention will be clearly and completely described below in conjunction with the embodiments. Apparently, the described embodiments are some but not all of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without any creative work shall fall within the scope of protection of the present invention.

[0024] Example 1

[0025] This example provides a bionic sebum composition, and its formula is shown in Table 1:

[0026] Table 1

[0027] Name Content / % Shea Butter 22 Olive Oil 40 Prinsepia Utilis Royle Oil 5 Cetearyl Alcohol 20 Jojoba Esters 5 Hydrogenated Lecithin 1 Phytosterols 1 Beeswax 3 Synthetic Squalane 1.5 VE Acetate 0.5 Portulaca Oleracea Extract 0.2 Rubus Idaeus Fruit Extract 0.2 Ceramide 0.6

[0028] This example provides the preparation method of the above bionic sebum, specifically: adding the required raw materials into a stirring kettle in the order of shea butter, olive oil, Prinsepia utilis Royle oil, cetearyl alcohol, beeswax, jojoba esters, hydrogenated lecithin, phytosterols, synthetic squalane, VE acetate, Portulaca oleracea extract, raspberry fruit extract, and ceramide, gradually heating to 50 °C, and continuously stirring until all raw materials are dissolved and the raw material mixture is homogeneous and transparent.

[0029] Examples 2-4

[0030] Examples 2-4 respectively provide a bionic sebum product, which is only different from Example 1 in terms of the formula, specifically as shown in Table 2.

[0031] Table 2

[0032]

[0033] Comparative Examples 1-7

[0034] Comparative Examples 1-7 respectively provided a biomimetic sebum product, which was only different in formulation compared with Example 1, as specifically shown in Table 3.

[0035] Table 3

[0036]

[0037]

[0038] Experimental Example 1

[0039] Hyaluronic acid (HA) has strong water absorption ability and adhesion, can regulate the secretion of cytokines, and affect cell growth, proliferation, migration and differentiation. Therefore, it plays a major role in maintaining skin moisture and elasticity, wound healing and angiogenesis. At the same time, hyaluronic acid is also involved in vasodilation and allergic reactions, so it is also closely related to skin sensitivity. Hyaluronidase is a specific lyase of hyaluronic acid, and its excessive activity will lead to the degradation of HA, resulting in the disintegration of the extracellular matrix, the reduction of joint viscosity, skin aging, and contributing to the development and progression of inflammation. The hyaluronidase inhibition experiment is the most typical in vitro method for evaluating soothing activity. The soothing activity of a substance is evaluated by the hyaluronidase inhibition rate. The greater the hyaluronidase inhibition rate, the stronger the soothing activity. The specific method is to measure the absorbance values of four solutions, and then calculate according to the following formula;

[0040] Hyaluronidase inhibition rate (%) = [(C - D) - (A - B)] / (C - D) × 100%

[0041] Where: A - OD value of the sample solution of (hyaluronidase + sample + sodium hyaluronate); B - OD value of the sample blank of (acetic acid buffer + sample + acetic acid buffer); C - OD value of the control solution of (hyaluronidase + deionized water + sodium hyaluronate);

[0042] D - OD value of the control blank of (acetic acid buffer + deionized water + acetic acid buffer). Among them, hyaluronidase: concentration 500 U / ml, freshly prepared and used immediately, not overnight, using acetic acid buffer as the solvent. Sodium hyaluronate: 0.5 mg / ml, prepared once and used multiple times, using acetic acid buffer as the solvent.

[0043] In this experimental example, the biomimetic sebum provided by Examples 1-4 and Comparative Examples 1-7 was selected as the test sample, and the texture and physical state of each group of products were measured. The results are shown in Table 4:

[0044] Table 4

[0045] Group Texture and Physical State Example 1 Soft waxy texture, moderate hardness, no oiliness Example 2 Soft waxy texture, moderate hardness, no oiliness Example 3 Waxy texture, slightly hard, no oiliness Example 4 Soft waxy texture, moderate hardness, no oiliness Comparative Example 1 Relatively soft state, oiliness on the surface Comparative Example 2 Texture is too hard Comparative Example 3 Texture is oily and sticky Comparative Example 4 Soft waxy texture, moderate hardness, no oiliness Comparative Example 5 Soft waxy texture, moderate hardness, no oiliness Comparative Example 6 Soft waxy texture, moderate hardness, no oiliness Comparative Example 7 Soft waxy texture, moderate hardness, no oiliness

[0046] The oil components in olive oil, Prinsepia utilis Royle seed oil, and shea butter are all somewhat similar to human sebum and are more easily compatible with human sebum, thus playing a barrier role. The combination of different oil ratios has an obvious impact on the texture and physical state of the product: in Comparative Example 1, the content of shea butter is 0, and the final product is in a softer state with oiliness on the surface; in Comparative Example 2, due to the absence of olive oil, the texture of the entire formulation is relatively hard; in Comparative Example 3, the cetearyl alcohol is missing, and the overall texture of the formulation is oily and sticky; considering that the bionic vernix caseosa needs to have skin-friendly properties, the formulation provided in Example 1 is the optimal one, with an overall melting range of 40 - 50 °C, suitable for application in cosmetics while ensuring its skin-friendly properties.

[0047] In addition, this experimental example also verified the bionic sebum soothing effect of each sample through experiments, and the results are shown in Table 5 below:

[0048] Table 5

[0049]

[0050] Based on the above experimental results: The bionic sebum provided by the present invention all has good soothing effects, and the composite lipids and plant extracts in the formulation both have certain effects on soothing. By comparing the test results of each group, it can be seen that the components that have a greater impact on soothing are Portulaca oleracea extract, Rubus idaeus fruit extract, and ceramide. Compared with Example 1, the soothing effects of Comparative Example 6 and Comparative Example 7 both decreased. In Comparative Example 6, the contents of Portulaca oleracea extract and Rubus idaeus fruit extract decreased significantly, so their soothing effects could not be effectively exerted. In Comparative Example 7, the contents of these two plant extracts increased significantly, but these two plant extracts themselves have certain irritating effects on the skin, resulting in a decrease in the soothing performance instead.

[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A bionic sebum composition, characterized in that, The composition components include the following parts by mass: 10 - 30 parts of shea butter, 30 - 60 parts of olive oil, 1 - 10 parts of Prinsepia utilis Royle oil, 10 - 30 parts of cetearyl alcohol, 1 - 10 parts of beeswax, 1 - 20 parts of jojoba esters, 0.1 - 5 parts of hydrogenated lecithin, 1 - 20 parts of phytosterols, 1 - 10 parts of synthetic squalane, 0.1 - 5 parts of VE acetate, 0.1 - 5 parts of Portulaca oleracea extract, 0.1 - 5 parts of raspberry fruit extract, and 0.1 - 5 parts of ceramide.

2. The bionic sebum composition according to claim 1, characterized in that, By mass percentage, the bionic sebum composition comprises: 10 - 30% of shea butter, 30 - 60% of olive oil, 1 - 10% of Prinsepia utilis Royle oil, 10 - 30% of cetearyl alcohol, 1 - 10% of beeswax, 1 - 20% of jojoba esters, 0.1 - 5% of hydrogenated lecithin, 1 - 20% of phytosterols, 1 - 10% of synthetic squalane, 0.1 - 5% of VE acetate, 0.1 - 5% of Portulaca oleracea extract, 0.1 - 5% of raspberry fruit extract, and 0.1 - 5% of ceramide.

3. The bionic sebum composition according to claim 2, wherein By mass percentage, the bionic sebum composition comprises: 15 - 30% of shea butter, 40 - 60% of olive oil, 1 - 10% of Prinsepia utilis Royle oil, 10 - 20% of cetearyl alcohol, 1 - 5% of beeswax, 1 - 10% of jojoba esters, 1 - 5% of hydrogenated lecithin, 1 - 10% of phytosterols, 1 - 5% of synthetic squalane, 0.1 - 2% of VE acetate, 0.1 - 3% of Portulaca oleracea extract, 0.1 - 3% of raspberry extract, and 0.1 - 3% of ceramide.

4. The bionic sebum composition according to claim 3, characterized in that By mass percentage, the bionic sebum composition comprises: 10 - 20% of shea butter, 40 - 50% of olive oil, 1 - 5% of Prinsepia utilis Royle oil, 10 - 15% of cetearyl alcohol, 1 - 3% of beeswax, 1 - 8% of jojoba esters, 1 - 3% of hydrogenated lecithin, 1 - 5% of phytosterols, 1 - 3% of synthetic squalane, 0.1 - 1% of VE acetate, 0.1 - 1% of Portulaca oleracea extract, 0.1 - 1% of raspberry fruit extract, and 0.1 - 3% of ceramide.

5. The preparation method of the bionic sebum composition according to any one of claims 1-4, characterized in that, The following steps are included: adding each raw material into a stirring kettle in the order of shea butter, olive oil, Prinsepia utilis Royle oil, cetearyl alcohol, beeswax, jojoba esters, hydrogenated lecithin, phytosterols, synthetic squalane, VE acetate, Portulaca oleracea extract, raspberry fruit extract, and ceramide, gradually heating to 50°C, and continuously stirring until all raw materials are dissolved and the raw material mixture is homogeneous and transparent.

6. Use of the bionic sebum composition according to any one of claims 1 - 4 in the preparation of infant cosmetics; preferably, the cosmetics include skin care products.

7. Use of the bionic sebum composition according to any one of claims 1 - 4 in soothing the skin for non - therapeutic purposes.

8. A cosmetic, characterized in that, Comprising the bionic sebum composition according to any one of claims 1 - 4.

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