Hand-warming hand cream as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to hand-warming hand cream as well as a preparation method and application thereof. The hand-warming hand cream is prepared from a traditional Chinese medicine extracting solution, shea butter, sweet almond oil, olive oil emulsifying wax, vitamin E oil, a humectant, a preservative, holly essential oil and water. The traditional Chinese medicine extracting solution is an aqueous extract of a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises Chinese angelica, cassia twig, Chinese herbaceous peony, liquorice, ricepaperplant pith, ginger, suberect spatholobus stem and mulberry twig. The traditional Chinese medicine extract is prepared from specific Chinese angelica, cassia twig, Chinese herbaceous peony, liquorice, ricepaperplant pith, ginger, suberect spatholobus stem and mulberry twig through a water extraction method, all the components have a synergistic effect, and the effects of replenishing blood, regulating ying, warming yang and dredging collaterals are achieved, so that the hand-warming hand cream has the effects of warming meridians, dredging collaterals, warming and dispelling cold, can well solve the problems of cold and stiffness of hands of people, is safe and has no toxic or side effects. The skin is mild and non-irritant.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and particularly relates to a hand-warming hand cream, a preparation method thereof, and an application thereof. Background Art

[0002] A hand cream is a skin care product that can moisturize the skin and prevent chapping, etc. It can effectively prevent and treat rough and chapped hands, and is especially suitable for use in autumn and winter. At present, there are a wide variety of hand creams on the market, but most of the products only have effects such as moisturizing and preventing chapping, antibacterial and anti-itching, and whitening, and very few have the effect of warming hands, and cannot solve the problem of "cold hands" existing in some people. In the cold winter, people's hands not only have problems of dryness and chapping, but also are prone to being cold and stiff. In order to obtain a hand cream with the effect of warming hands, usually a heat-sensing agent is added to the hand cream, and the heat-sensing agent quickly generates heat to give the hand cream the effect of warming and dispelling cold, but people with sensitive skin are prone to skin burns when using such hand creams, and the experience is poor. Or add traditional Chinese medicine substances such as Asarum sieboldii to give the effect of warming hands, but Asarum sieboldii has certain toxicity and is not good for the human body.

[0003] Therefore, it is of great significance to develop a hand cream that combines the functions of promoting blood circulation and removing meridian obstruction, warming and dispelling cold, and moisturizing, and is safe. Summary of the Invention

[0004] The present invention aims to solve one or more of the above-mentioned technical problems existing in the prior art, and at least provides a beneficial option. Specifically, the present invention provides a hand-warming hand cream, which combines the functions of promoting blood circulation and removing meridian obstruction, warming and dispelling cold, and moisturizing, can significantly improve the problem of cold hands in winter, and is safe.

[0005] Inventive concept of the present invention: The hand-warming hand cream of the present invention comprises a traditional Chinese medicine extract, shea butter, sweet almond oil, olive oil emulsifying wax, vitamin E oil, a humectant, a preservative, wintergreen essential oil and water; the traditional Chinese medicine extract is an aqueous extract of a traditional Chinese medicine composition; the traditional Chinese medicine composition comprises angelica sinensis, cassia twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig. The angelica sinensis, cassia twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig in the traditional Chinese medicine extract of the present invention have synergistic effects; angelica sinensis is sweet and warm, enters the liver meridian, and has the effects of enriching blood and regulating blood; cassia twig is pungent, warm and dispels cold, and the two together serve as the monarch drugs; millettia reticulata is bitter, sweet and warm, enriches blood and promotes blood circulation, relaxes muscles and activates collaterals, can not only enhance the blood-activating effect of angelica sinensis, but also is beneficial to cassia twig in dredging collaterals and dispelling cold; tetrapanax papyriferus dredges the meridians, mulberry twig is slightly bitter, neutral in nature, dispels wind and promotes diuresis, dredges and benefits joints, enters the hands and feet and four limbs, strengthens the local effect, and can act together to enhance the effect of cassia twig in warming and dredging blood vessels; ginger is pungent and slightly warm, which helps cassia twig in warming and dredging and dispelling cold; the red peony root in white peony root promotes blood circulation and removes stasis, the white peony root nourishes blood and harmonizes nutrient qi, and relieves spasm and pain; licorice root has a harmonizing effect on the above-mentioned various drugs, such as preventing cassia twig from being too dry and damaging yin and blood. The components in the traditional Chinese medicine extract act synergistically, have the effects of enriching blood, regulating nutrient qi, warming yang and dredging meridians, and the compatibility is warm but not dry, tonifying but not stagnating, and combined with other components, so that the hand-warming hand cream has the effects of warming meridians and dredging collaterals, warming and dispelling cold, moisturizing and being safe, and can significantly improve the problems of cold hands and chapped hands in winter. In addition, wintergreen essential oil is a safe and natural plant essential oil, has the effects of relieving muscle stiffness and tension and reducing muscle pain, and can soothe the skin state when combined with other components, and has a promoting effect on warming and dispelling cold and promoting blood circulation.

[0006] Therefore, in the first aspect of the present invention, a hand-warming hand cream is provided.

[0007] Specifically, the hand-warming hand cream comprises a traditional Chinese medicine extract, shea butter, sweet almond oil, olive oil emulsifying wax, vitamin E oil, a humectant, a preservative, wintergreen essential oil and water;

[0008] The traditional Chinese medicine extract is an aqueous extract of a traditional Chinese medicine composition;

[0009] The traditional Chinese medicine composition comprises angelica sinensis, cassia twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig.

[0010] Traditional Chinese medicine components react with each other during the decocting process through compatibility, and have different manifestations in terms of absorption, distribution, metabolism, and excretion after entering the body, affecting the final therapeutic effect. Therefore, they have the characteristics of multiple drugs, multiple components, multiple targets, and multiple pathways to treat diseases or reduce toxic damage. Through reasonable compatibility, the metabolism process of active ingredients and toxic substances in the body can be affected, thereby achieving the effect of enhancing efficacy and reducing toxicity. In addition, the interaction between drugs is not a simple linear superposition, but occurs in a complex biological internal environment, involving the regulation of multiple biomolecules and signaling pathways. The warm hand and hand cream of the present invention is an original compatibility combination obtained by the inventor based on his own clinical experience. Through the combined action of each component of the drug extract, the effect of enhancing efficacy and reducing toxicity is achieved, the efficacy of promoting blood circulation to dredge collaterals and warming the local area is enhanced, and in combination with components such as shea butter, sweet almond oil, and olive oil emulsifying wax, the purpose of moisturizing and nourishing is achieved, enhancing the overall effect of the warm hand and hand cream.

[0011] Preferably, the mass ratio of Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori is 1:(0.8 - 1.2):(0.8 - 1.2):(0.55 - 0.9):(0.55 - 0.9):(0.8 - 1.2):(0.55 - 0.9):(0.35 - 0.65).

[0012] More preferably, the mass ratio of Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori is 1:(0.9 - 1.1):(0.9 - 1.1):(0.6 - 0.8):(0.6 - 0.8):(0.9 - 1.1):(0.6 - 0.8):(0.4 - 0.6).

[0013] Specifically, the traditional Chinese medicine extract is prepared by the water extraction method.

[0014] Preferably, the traditional Chinese medicine extract is prepared by the following method: pulverize and mix Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori, then add water for decoction, filter, and take the filtrate for evaporation and concentration to obtain the traditional Chinese medicine extract.

[0015] Preferably, the addition amount of water is 13 - 27 times the total mass of Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori.

[0016] More preferably, the addition amount of water is 15 - 25 times the total mass of Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori.

[0017] Even more preferably, the addition amount of water is 19 times the total mass of Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus Mori.

[0018] Preferably, the decocting time is 18 min - 27 min; more preferably, the decocting time is 20 min - 25 min; even more preferably, the decocting time is 20 min.

[0019] Preferably, before decocting, let it stand still, and the standing time is 25 min - 35 min; more preferably, the standing time is 27 min - 33 min; even more preferably, the standing time is 30 min.

[0020] Preferably, the specific operation of evaporation and concentration is as follows: Take the filtrate and evaporate and concentrate it to 1 / 12 - 1 / 8 of the original volume; more preferably, take the filtrate and evaporate and concentrate it to 1 / 10 of the original volume.

[0021] Preferably, the humectant includes at least one of propylene glycol, glycerol, butylene glycol, panthenol, and ceramide.

[0022] Preferably, the preservative includes at least one of phenoxyethanol, benzyl alcohol, and p - hydroxyacetophenone.

[0023] Preferably, by mass percentage, the hand - warming and hand - protecting cream includes 3.5% - 9% of traditional Chinese medicine extract, 5.5% - 11% of shea butter, 6.5% - 11% of sweet almond oil, 1.8% - 11% of olive oil emulsifying wax, 0.9% - 3.3% of vitamin E oil, 3.5% - 9% of humectant, 0.45% - 1.0% of preservative, 0.45% - 0.9% of wintergreen essential oil, and 45% - 75% of water.

[0024] More preferably, by mass percentage, the hand - warming and hand - protecting cream includes 4% - 8% of traditional Chinese medicine extract, 6% - 10% of shea butter, 7% - 10% of sweet almond oil, 2% - 10% of olive oil emulsifying wax, 1% - 3% of vitamin E oil, 4% - 8% of humectant, 0.5% - 0.9% of preservative, 0.5% - 0.8% of wintergreen essential oil, and 50% - 70% of water.

[0025] The second aspect of the present invention provides a preparation method of the hand - warming and hand - protecting cream described in the first aspect of the present invention.

[0026] Specifically, the preparation method of the hand - warming and hand - protecting cream includes the following steps:

[0027] (1) Mix the shea butter, sweet almond oil, and olive oil emulsifying wax, heat, and keep warm to make mixture A, and mix the humectant and water, heat, and keep warm to make mixture B;

[0028] (2) Mix the obtained mixture B and mixture A from step (1), cool down the temperature, and then add the traditional Chinese medicine extract, vitamin E oil, wintergreen essential oil and preservative for mixing. After aging, the warm hand and hand cream is obtained.

[0029] Preferably, in step (1), heat to 65°C - 90°C; more preferably, heat to 70°C - 85°C.

[0030] Preferably, in step (1), the heat preservation time is 4 min - 17 min; more preferably, the heat preservation time is 5 min - 15 min.

[0031] Specifically, in step (1), the heating temperature and heat preservation time for preparing mixture A and the heating temperature and heat preservation time for preparing mixture B can be the same or different.

[0032] Preferably, in step (2), add the obtained mixture B from step (1) to mixture A for mixing.

[0033] Preferably, in step (2), cool down the temperature to 45°C - 60°C; more preferably, cool down the temperature to 50°C - 55°C.

[0034] Preferably, in step (2), the aging is carried out at room temperature, and the aging time is 18 h - 33 h; more preferably, the aging is carried out at room temperature, and the aging time is 20 h - 30 h.

[0035] The third aspect of the present invention provides an application of the warm hand and hand cream described in the first aspect of the present invention in the field of skin care products.

[0036] Compared with the prior art, the beneficial effects of the technical solution provided by the present invention are as follows:

[0037] (1) The warm hand and hand cream of the present invention is added with a traditional Chinese medicine extract prepared by water extraction from Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata and Morus alba. The components in the traditional Chinese medicine extract act synergistically, having the effects of enriching blood, regulating nutrient qi, warming yang and dredging meridians. And the compatibility is warm but not dry, tonifying but not stagnating, jointly playing the efficacy of warming meridians and dredging collaterals, so that the warm hand and hand cream has the effects of warming meridians and dredging collaterals, warming and dispelling cold, can well solve the problems of cold and stiff hands of people, and is green, safe, mild and non-irritating to the skin.

[0038] (2) The warm hand and hand cream of the present invention is added with shea butter, sweet almond oil, olive oil emulsifying wax, vitamin E oil, wintergreen essential oil and a moisturizer. The components act together, having excellent moisturizing, moistening dryness and preventing chapping effects, and can well solve the problems of rough and chapped hand skin of people.

[0039] (3) The preparation method of the hand-warming hand cream of the present invention is simple and fast, without the need to use special instrument and equipment, and is convenient for large-scale production and application. Description of the Drawings

[0040] Figure 1 It is the blood perfusion map of the back skin of rats a and b;

[0041] Figure 2 It is the blood perfusion map of the back skin of rats B and C;

[0042] Figure 3 It is the blood flow rate-time relationship curve of the back skin of rats a, b, c, d, and e;

[0043] Figure 4 It is the blood flow rate-time relationship curve of the back skin of rats A, B, C, D, and E;

[0044] Figure 5 It is the blood flow rate-time relationship curve of the back skin of rats f, g, F, and G. Detailed Embodiments

[0045] In order to make the technical solutions described in the present invention more clearly understood by those skilled in the art, the following examples are listed for illustration. It should be noted that the following examples do not limit the scope of protection required by the present invention.

[0046] The raw materials, reagents or devices used in the following examples can be obtained from conventional commercial channels or can be obtained by existing known methods without special instructions.

[0047] Example 1

[0048] A hand-warming hand cream, the raw material components and dosages thereof are shown in Table 1.

[0049] Table 1: Raw material components and dosages of the hand-warming hand cream

[0050]

[0051]

[0052] Among them, the traditional Chinese medicine extract is prepared by the following method:

[0053] Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Zingiber officinale, Millettia reticulata, and Ramulus mori with a mass ratio of 1:1:1:0.7:0.7:0.9:0.7:0.5 are fully pulverized and mixed evenly, then 19 times the weight of distilled water is added and left standing for 30 min, then decocted for 20 min, filtered, and the filtrate is evaporated and concentrated to 1 / 10 of the original volume to obtain the traditional Chinese medicine extract.

[0054] The preparation method of the above-mentioned hand-warming hand cream comprises the following steps:

[0055] (1) Mix shea butter, sweet almond oil and olive oil emulsifying wax, heat the mixture to 80°C and keep it warm for 10 minutes to form mixture A; mix propylene glycol and distilled water, heat the mixture to 80°C and keep it warm for 10 minutes to form mixture B;

[0056] (2) Add mixture B to mixture A under stirring. After adding, continue stirring for 10 minutes, then cool down to 50°C, add traditional Chinese medicine extract, wintergreen essential oil, vitamin E oil and phenoxyethanol, stir for 5 minutes, and then cool to room temperature and age for 24 hours to obtain the hand-warming hand cream.

[0057] Example 2

[0058] A hand-warming hand cream, the raw material components and dosages thereof are shown in Table 2.

[0059] Table 2: Raw material components and dosages of the hand-warming hand cream

[0060]

[0061]

[0062] Among them, the preparation process of the traditional Chinese medicine extract is the same as that in Example 1.

[0063] The preparation method of the above-mentioned hand-warming hand cream comprises the following steps:

[0064] (1) Mix shea butter, sweet almond oil and olive oil emulsifying wax, heat the mixture to 80°C and keep it warm for 10 minutes to form mixture A, and mix propylene glycol and distilled water, heat the mixture to 80°C and keep it warm for 10 minutes to form mixture B;

[0065] (2) Add mixture B to mixture A under stirring. After adding, continue stirring for 10 minutes, then cool down to 50°C, add traditional Chinese medicine extract, wintergreen essential oil, vitamin E oil and phenoxyethanol, stir for 5 minutes, and then cool to room temperature and age for 24 hours to obtain the hand-warming hand cream.

[0066] Example 3

[0067] A hand-warming hand cream, the raw material components and dosages thereof are shown in Table 3.

[0068] Table 3: Raw material components and dosages of the hand-warming hand cream

[0069] Raw material Mass percentage (%) Chinese medicine extract 5 Shea butter 9 Sweet almond oil 8 Olive oil emulsifying wax 3 Propylene glycol 6 Vitamin E oil 2 Wintergreen essential oil 0.8 Phenoxyethanol 0.7 Distilled water 65.5

[0070] Among them, the preparation process of the traditional Chinese medicine extract is the same as that in Example 1.

[0071] The preparation method of the above-mentioned hand-warming hand cream comprises the following steps:

[0072] (1) Mix shea butter, sweet almond oil and olive oil emulsifying wax, heat the mixture to 80 °C and keep it warm for 10 min to prepare mixture A. Mix propylene glycol and distilled water, heat the mixture to 80 °C and keep it warm for 10 min to prepare mixture B;

[0073] (2) Add mixture B to mixture A under stirring. After the addition, continue stirring for 10 min, then cool down to 50 °C, add traditional Chinese medicine extract, wintergreen essential oil, vitamin E oil and phenoxyethanol, stir for 5 min, and then age for 24 h after cooling to room temperature to obtain the hand-warming hand cream.

[0074] Comparative Example 1

[0075] The hand cream of Comparative Example 1 is composed of the following raw material components in mass percentages: traditional Chinese medicine extract 6%, shea butter 8%, sweet almond oil 8%, olive oil emulsifying wax 3%, humectant propylene glycol 6%, preservative phenoxyethanol 0.7%, distilled water 68.3%.

[0076] Among them, the traditional Chinese medicine extract is prepared by the following method:

[0077] Crush and mix Angelica sinensis, Cinnamomum cassia, Paeonia lactiflora, Glycyrrhiza uralensis, Tetrapanax papyriferus, Asarum sieboldii and Ziziphus jujuba with a mass ratio of 1:1:1:0.7:0.7:1:0.7, then add 19 times the weight of distilled water, mix and let stand for 30 min, then decoct for 20 min, filter, and evaporate and concentrate the filtrate to 1 / 10 of the original volume to obtain the traditional Chinese medicine extract.

[0078] The preparation method of the above-mentioned hand cream comprises the following steps:

[0079] (1) Mix shea butter, sweet almond oil and olive oil emulsifying wax, heat the mixture to 80 °C and keep it warm for 10 min to prepare mixture A. Mix propylene glycol and distilled water, heat the mixture to 80 °C and keep it warm for 10 min to prepare mixture B;

[0080] (2) Add mixture B to mixture A under stirring. After the addition, continue stirring for 10 min, then cool down to 50 °C, add traditional Chinese medicine extract and phenoxyethanol, stir for 5 min, and then age for 24 h after cooling to room temperature to obtain the hand-warming hand cream.

[0081] Performance test

[0082] Test for improving local skin blood flow

[0083] Use laser speckle to measure skin blood flow. The test method is as follows:

[0084] (1) Fix the rats on the fixing rack, anesthetize the rats by intraperitoneal injection of 1 wt% sodium pentobarbital (5 mL / kg). After 3 - 5 min, roughly cut the hair on the back test site close to the skin with curved scissors, cut out two areas of the same size, quickly dip and wash the test site with 8% sodium sulfide solution. After 2 - 3 min, wait until the hair dissolves into a paste, scrub it clean with a wet gauze, and immediately wash it thoroughly with physiological saline after hair removal to expose the skin of the test site for standby;

[0085] (2) Keep the rats after hair removal for 24 h under the same temperature condition, divide them into two groups, with 5 rats in each group. Apply the warm hand cream of Example 1 to the left - hand side area of the back of the first - group rats, and apply the hand cream containing only the matrix (the same as the warm hand cream of Example 1 except that the traditional Chinese medicine extract is replaced with an equal amount of distilled water) to the right - hand side area of the back, numbered a, b, c, d, e. Apply the warm hand cream of Example 1 to the left - hand side area of the back of the second - group rats, and leave the right - hand side area of the back blank without applying any substance as the blank control group, numbered A, B, C, D, E. Before applying the hand cream, 0 min, 15 min, 30 min, 45 min, and 60 min after application, place a laser speckle probe above the back test site of the rats to detect the blood flow velocity of the local skin on the back. Use PU as the unit of relative blood flow. After the detection is completed, the rats wake up naturally.

[0086] a) Appearance color observation

[0087] Select rats a and b from the first group to observe blood perfusion. The blood perfusion images are as Figure 1 shown. Among them, Figure 1 Figures (a) and (b) in Figure 1 are the blood perfusion images of rat a after 30 min and 60 min of application respectively, and

[0088] Figure 1 Figures (c) and (d) in Figure 1 are the blood perfusion images of rat b after 30 min and 60 min of application respectively. The boxes in the figures indicate the application sites.

[0089] Select rats B and C from the second group to observe blood perfusion. The blood perfusion images are as Figure 2 shown. Among them, Figure 2Figures (a) and (b) therein are the blood perfusion images of Rat B after smearing for 30 minutes and 60 minutes respectively. Figure 2 Figures (c) and (d) therein are the blood perfusion images of Rat C after smearing for 30 minutes and 60 minutes respectively. The left square area in each figure is the area smeared with the hand-warming and hand-protecting cream of Example 1, and the right square area is the observation area of the blank control group.

[0090] Figure 2 The blue area therein represents a decrease in blood flow, and the orange-red area represents an increase in blood flow. Figure 2 It can be seen that the difference in blood flow on the left and right sides of the rat's back is obvious. Compared with the blank control group without smearing any substance, after smearing the hand-warming and hand-protecting cream of Example 1, the blood flow on the skin surface of the rat has changed, and its blood flow is more than that of the blank control group, indicating that the hand-warming and hand-protecting cream of Example 1 of the present invention has significantly higher ability to increase blood flow than the blank control group.

[0091] Local skin blood flow is related to heat dissipation. Through the skin blood flow test, the influence of the hand-warming and hand-protecting cream on the local skin heat sensation can be reflected, and further it shows that the hand-warming and hand-protecting cream of the present invention has the hand-warming effect of promoting blood circulation and removing cold, and warming and dispelling cold.

[0092] In addition, through the same test, the hand-warming and hand-protecting creams of Example 2 and Example 3 also have good effects on improving skin blood flow.

[0093] b) Analyze the effect of the traditional Chinese medicine extract by the first and last method

[0094] The test found that the blood flow on the left side of the rat's back skin was often higher than that on the right side before the smearing intervention, which was considered to be related to the fact that the blood flow on the left side of the rat's back was closer to the heart. Therefore, the difference in blood flow between the left and right sides before (before smearing) and after (after smearing) the intervention was selected to exclude the physiological difference in blood flow between the left and right sides, and analyze the effective effect of the intervention measure.

[0095] The calculation formula is: △X 干预前左右差值 = X 0min左 - X 0min右 ; △X 干预后左右差值 = X 60min左 - X 60min右 (X represents the unilateral blood flow of a certain rat).

[0096] Before and after the intervention of Rats a, b, c, d, and e, the difference in blood flow between the left and right sides of the back skin is shown in Table 4.

[0097] Table 4: Difference in blood flow between the left and right sides of the back skin of Rats a, b, c, d, and e before and after the intervention

[0098]

[0099] Before and after the intervention of rats A, B, C, D, and E, the difference in blood flow between the left and right sides of the back skin is shown in Table 5.

[0100] Table 5: Difference in blood flow between the left and right sides of the back skin of rats A, B, C, D, and E before and after the intervention

[0101]

[0102] By comparing the left - right differences before and after the intervention in Tables 4 and 5, it can be seen that for the five rats in each of the two major groups, △X 干预前左右差值 <△X 干预后左右差值 , with the warm - hand and hand - protecting cream of Example 1 on the left side of the back and the hand - protecting cream containing only the matrix or the blank control group on the right side of the back. This shows that after the intervention of the warm - hand and hand - protecting cream of the present invention, the difference in blood flow between the left and right sides of the back can be increased, that is, adding the traditional Chinese medicine extract in the warm - hand and hand - protecting cream of Example 1 of the present invention can increase blood flow.

[0103] In addition, after the same test, applying the warm - hand and hand - protecting creams of Example 2 and Example 3 of the present invention can also increase the difference in blood flow between the left and right sides of the back. That is, adding the traditional Chinese medicine extract in the warm - hand and hand - protecting creams of Example 2 and Example 3 of the present invention can also increase blood flow.

[0104] c) Analyze the effect of the traditional Chinese medicine extract by the slope method

[0105] When observing the blood flow data of the two groups of mice, it was found that before 30 minutes, the change in skin blood flow on the left and right sides of the back showed no obvious pattern. Between 30 - 60 minutes, regardless of whether the hand - protecting cream containing only the matrix was applied or no substance was applied on the right side of the back, the difference in the increase in blood flow of the group with the warm - hand and hand - protecting cream applied on the left side of the back of each rat was greater than that on the right side.

[0106] Using SPSS software and the paired - sample T - test method, to test whether there is a significant difference in the difference in blood flow changes between the left and right sides of the back from 30 to 60 minutes. The results show that compared with the hand - protecting cream containing only the matrix, for the warm - hand and hand - protecting cream of Example 1, P = 0.04 < 0.05, which is statistically significant; compared with the blank control group, for the warm - hand and hand - protecting cream of Example 1, P = 0.069 > 0.05 and < 0.1, which is significant at the 10% level, probably related to the relatively small sample size.

[0107] The difference in blood flow changes between the left and right sides of the back of rats a, b, c, d, and e at 30 min and 60 min is shown in Table 6; the difference in blood flow changes between the left and right sides of the back of rats A, B, C, D, and E at 30 min and 60 min is shown in Table 7.

[0108] Table 6: Difference in blood flow changes between the left and right sides of the back of rats a, b, c, d, and e at 30 min and 60 min

[0109]

[0110] Table 7: Difference in blood flow changes on the left and right sides of the backs of Rats A, B, C, D, and E at 30 min and 60 min

[0111]

[0112] From the difference in blood flow changes in Tables 6 and 7, it can be seen that after 30 min and 60 min of application, the difference in blood flow changes in the back skin of the rats applied with the hand-warming and hand-care cream of Example 1 is significantly greater than that of the hand-care cream containing only the matrix, and also greater than that of the blank control group, indicating that the hand-warming and hand-care cream of Example 1 of the present invention can significantly increase blood flow. And the P value obtained after statistical hypothesis testing is also around 0.1. Although it is greater than 0.05, there is already a trend of difference. It is possible that positive results can be obtained after increasing the sample size of the experimental rats.

[0113] The blood flow-time relationship curves of the back skin of Rats a, b, c, d, and e are as Figure 3 shown. The abscissa is time and the ordinate is blood flow. Among them, the hand-warming and hand-care cream of Example 1 is applied to the left back area of the rats, and the hand-care cream containing only the matrix is applied to the right back area. Figure 3 In Figures (a), (b), (c), (d), and (e) are the blood flow-time relationship curves of the back skin of Rats a, b, c, d, and e respectively. The blue solid lines in each figure represent the blood flow-time relationship curves of the left back area of the rats at different time periods, and the red solid lines and orange solid lines represent the blood flow-time relationship curves of the right back area of the rats at different time periods. And the dotted lines in each figure are to highlight the difference degree of the blood flow change slope in the interval from 30 minutes to 60 minutes.

[0114] The blood flow-time relationship curves of the back skin of Rats A, B, C, D, and E are as Figure 4 shown. The abscissa is time and the ordinate is blood flow. Among them, the hand-warming and hand-care cream of Example 1 is applied to the left back area of the rats, and the right back area is the blank control group without applying any substance. Figure 4 In Figures (a), (b), (c), (d), and (e) are the blood flow-time relationship curves of the back skin of Rats A, B, C, D, and E respectively. The blue solid lines in each figure represent the blood flow-time relationship curves of the left back area of the rats at different time periods, and the red solid lines and orange solid lines represent the blood flow-time relationship curves of the right back area of the rats at different time periods. And the dotted lines in the figures are to highlight the difference degree of the blood flow change slope in the interval from 30 minutes to 60 minutes.

[0115] From Figure 3 , 4It can be seen that the slope of the blood flow change after applying the hand-warming and hand-protecting cream of Example 1 is significantly steeper than that of the hand-protecting cream containing only the matrix and the blank control group, indicating that the hand-warming and hand-protecting cream of Example 1 containing the traditional Chinese medicine extract has a more significant effect on increasing blood flow. Whether comparing the hand-warming and hand-protecting cream of Example 1 with the hand-protecting cream containing only the matrix or with the blank control group, there is no obvious pattern in the blood flow changes on the left and right sides of the rat's back in the first 30 minutes. The reasons may be as follows: the traditional Chinese medicine components in the hand-warming and hand-protecting cream take effect slowly and the effect is not obvious in the first 30 minutes; the blood vessels contract significantly after the rats are anesthetized, exceeding the effect of the traditional Chinese medicine components; the number of experimental rats is small and the bias pattern is not obvious; there are components with pungent and cool effects in the traditional Chinese medicine extract, and the cool feeling is relatively heavy in the initial stage. During the volatilization process of this component, it will gradually promote blood vessel dilation and increase blood flow, similar to the principle of action of essential balm.

[0116] In addition, using the same method, the effect of the hand-protecting cream of Comparative Example 1 on local skin blood flow was tested. The specific test method is as follows:

[0117] (1) Fix the rats on the fixing frame, anesthetize the rats by intraperitoneal injection of 1wt% sodium pentobarbital (5 mL / kg). After 3 - 5 minutes, roughly cut off the hair on the back test site close to the skin with a pair of curved scissors, cut out two areas of the same size, quickly dip and wash the test site with 8% sodium sulfide solution. After 2 - 3 minutes, wait until the hair dissolves into a paste, scrub it clean with a wet gauze, and immediately wash it thoroughly with physiological saline after depilation to expose the skin of the test site for standby;

[0118] (2) After 24 hours of depilation, place the rats under the same temperature conditions and divide them into two groups, with two rats in each group. The two rats in the first group are numbered f and g respectively. On the left side of the back of rat f, apply the hand-protecting cream containing only the matrix (the same as the hand-protecting cream of Comparative Example 1 except that the traditional Chinese medicine extract of Comparative Example 1 is replaced with an equal amount of distilled water), and on the right side of the back, apply the hand-protecting cream of Comparative Example 1. On the left side of the back of rat g, apply the hand-protecting cream of Comparative Example 1, and on the right side of the back, apply the hand-protecting cream containing only the matrix (considering eliminating the influence of physiological blood flow on the left and right sides); The two rats in the second group are numbered F and G respectively. No substance is applied on the left side as the blank control group, and the hand-protecting cream of Comparative Example 1 is applied on the right side; Before applying the hand-protecting cream, and at 0 min, 15 min, 30 min, 45 min, and 60 min after application, place a laser speckle probe above the test site on the rat's back to detect the blood flow velocity of the local skin. Use PU as the relative blood flow unit, and let the rats wake up naturally after the detection is completed.

[0119] The blood flow-time relationship curves of the back skin of rats f, g, F, and G are as Figure 5 shown. Figure 5Figures (a), (b), (c), and (d) are the blood flow-time relationship curves of the back skin of rats f, g, F, and G, respectively; the blue solid line and orange solid line in Figure (a) represent the blood flow-time relationship curves of the right and left regions of the back of rat f, respectively, the blue solid line and red solid line in Figure (b) represent the blood flow-time relationship curves of the left and right regions of the back of rat g, respectively, the blue solid line and orange solid line in Figure (c) represent the blood flow-time relationship curves of the right and left regions of the back of rat F, respectively, the blue solid line and orange solid line in Figure (d) represent the blood flow-time relationship curves of the right and left regions of the back of rat G, respectively, and the dotted line in the figure is to highlight the difference degree of the blood flow change slope in the interval from 30 minutes to 60 minutes.

[0120] It can be seen from Figure 5 that no matter whether the hand cream containing the traditional Chinese medicine extract in Comparative Example 1 is applied to the left or right side of the back of the rat, △X 干预前中药与对照组差值 is less than △X 干预后中药与对照组差值 (X represents the unilateral blood flow of a certain rat, and the control group refers to the hand cream containing only the matrix), and it can be inferred that compared with the hand cream containing only the matrix and the blank control group, the hand cream in Comparative Example 1 can increase the local blood flow after 1 hour of intervention.

[0121] Analysis of the effect of the traditional Chinese medicine extract by the head and tail method:

[0122] The calculation formula is: △X 干预前左右差值 =X 0min中药 -X 0min空白 / 基质 ; △X 干预后左右差值 =X 60min中药 -X 60min空白 / 基质 (X represents the unilateral blood flow of a certain rat).

[0123] Before and after the intervention of rats f, g, F, and G, the blood flow differences between the left and right sides of the back skin are shown in Table 8 below.

[0124] Table 8: Blood flow differences between the left and right sides of the back skin of rats f, g, F, and G before and after intervention

[0125]

[0126] It can be seen from the left and right side differences before and after the intervention in Table 8 that △X 干预前左右差值 <△X 干预后左右差值 for the two rats in each of the two major groups, indicating that after the intervention of the hand cream for warming hands and protecting hands in Comparative Example 1, the difference in blood flow between the left and right sides of the back can be increased, that is, adding the traditional Chinese medicine extract to the hand cream for warming hands and protecting hands in Comparative Example 1 can increase the blood flow.

[0127] After applying the warm hand and hand cream of Comparative Example 1 and the hand cream containing only the matrix for 30 minutes and 60 minutes, calculate the difference in the change of blood flow in the back skin of the rats, and calculate the difference in the change of blood flow in the back skin of the rats in the blank control group at 30 minutes and 60 minutes. The differences in the change of blood flow on the left and right sides of the backs of rats f and g at 30 minutes and 60 minutes are shown in Table 8; the differences in the change of blood flow on the left and right sides of the backs of rats F and G at 30 minutes and 60 minutes are shown in Table 9.

[0128] Table 9: Differences in the change of blood flow on the left and right sides of the backs of rats f and g at 30 minutes and 60 minutes

[0129]

[0130]

[0131] Table 10: Differences in the change of blood flow on the left and right sides of the backs of rats F and G at 30 minutes and 60 minutes

[0132]

[0133] As can be seen from Tables 9 and 10, after applying for 30 minutes and 60 minutes, the ability of the traditional Chinese medicine side of rats f and g to increase blood flow on the back is poor; on the backs of rats F and G, the change in blood flow on the traditional Chinese medicine side decreases more slowly than that of the blank, indicating that the ability of the hand cream of Comparative Example 1 to increase blood flow after 30 minutes of application is better than that of the blank control group.

[0134] And as can be seen from the aforementioned Tables 6 and 7, after applying for 30 minutes and 60 minutes, the difference in the blood flow of the skin of the rats applying the warm hand and hand cream of Example 1 is significantly greater than that of the hand cream containing only the matrix, and also greater than that of the blank control group. It shows that after applying for 30 minutes and 60 minutes, the ability of the hand cream of Comparative Example 1 to increase blood flow is worse than that of the warm hand and hand cream of Example 1, and the persistence of the warm hand and hand cream of Example 1 in increasing blood flow is better than that of the hand cream of Comparative Example 1.

[0135] In addition, the warm hand and hand creams of Example 2 and Example 3 have the same effect as the warm hand and hand cream of Example 1.

[0136] To sum up, the traditional Chinese medicine extract of the present invention is prepared by a water extraction method from specific components of Angelica sinensis, Cinnamon twig, Paeonia lactiflora, Licorice, Tetrapanax papyriferus, Ginger, Millettia reticulata, and Mori Ramulus. The components act synergistically to play the roles of enriching blood, regulating nutrient qi, warming yang, and dredging meridians, so that the warm hand and hand cream has the effects of warming meridians and dredging collaterals, warming and dispelling cold, can well solve the problems of cold and stiffness of people's hands, and is safe, mild and non-irritating to the skin.

[0137] The above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A hand-warming hand cream, characterized in that, It includes Chinese medicine extract, shea butter, sweet almond oil, olive oil emulsifying wax, vitamin E oil, humectant, preservative, wintergreen essential oil and water; The Chinese medicine extract is the water extract of a Chinese medicine composition; The Chinese medicine composition includes angelica sinensis, cinnamon twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig.

2. The warm hand and hand care cream according to claim 1, wherein: The mass ratio of angelica sinensis, cinnamon twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig is 1:(0.8 - 1.2):(0.8 - 1.2):(0.55 - 0.9):(0.55 - 0.9):(0.8 - 1.2):(0.55 - 0.9):(0.35 - 0.65).

3. The hand-warming hand cream according to claim 2, wherein: The Chinese medicine extract is prepared by the following method: crushing and mixing angelica sinensis, cinnamon twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig, then adding water for decoction, filtering, and taking the filtrate for evaporation and concentration to obtain the Chinese medicine extract.

4. The warm hand and hand care cream according to claim 3, characterized in that: The addition amount of water is 13 - 27 times the total mass of angelica sinensis, cinnamon twig, white peony root, licorice root, tetrapanax papyriferus, ginger, millettia reticulata and mulberry twig.

5. The hand-warming hand cream according to claim 3, wherein: The decoction time is 18 min - 27 min; and / or, the specific operation of evaporation and concentration is: taking the filtrate for evaporation and concentration until the volume is 1 / 12 - 1 / 8 of the original volume.

6. The warm hand and hand cream according to claim 1, characterized in that: The humectant includes at least one of propylene glycol, glycerol, butylene glycol, panthenol, ceramide; and / or, the preservative includes at least one of phenoxyethanol, benzyl alcohol, p - hydroxyacetophenone.

7. The hand-warming hand cream according to any one of claims 1-6, characterized in that: By mass percentage, the hand - warming and hand - protecting cream includes 3.5% - 9% of Chinese medicine extract, 5.5% - 11% of shea butter, 6.5% - 11% of sweet almond oil, 1.8% - 11% of olive oil emulsifying wax, 0.9% - 3.3% of vitamin E oil, 3.5% - 9% of humectant, 0.45% - 1.0% of preservative, 0.45% - 0.9% of wintergreen essential oil, and 45% - 75% of water.

8. The preparation method of the hand-warming hand cream according to any one of claims 1-7, characterized in that, It includes the following steps: (1) Mix shea butter, sweet almond oil and olive oil emulsifying wax, heat and keep warm to make mixture A, and mix the humectant and water, heat and keep warm to make mixture B; (2) Mix mixture B and mixture A obtained in step (1), cool down, then add the Chinese medicine extract, vitamin E oil, wintergreen essential oil and preservative and mix, and age to obtain the hand - warming and hand - protecting cream.

9. The preparation method according to claim 8, characterized in that: In step (1), heat to 65℃ - 90℃; and / or, the heat - keeping time is 4 min - 17 min; and / or, in step (2), cool down to 45℃ - 60℃; and / or, the aging is carried out at room temperature, and the aging time is 18 h - 33 h.

10. The application of the hand - warming and hand - protecting cream according to any one of claims 1 - 7 in the field of skin care products.

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