Polyacid composite oil-controlling and acne-removing gel and preparation method thereof

Abstract

The invention relates to a polyacid composite oil-controlling and acne-removing gel and a preparation method thereof, and belongs to the technical field of skin care products. The polyacid composite oil-controlling and acne-removing gel is prepared from the following components in percentage by mass: 2% of salicylic acid, 3%-4% of glycolic acid, 0.5%-1.5% of mandelic acid, 0.5%-1.0% of lactobionic acid, 0.5%-1.0% of gluconolactone, 1.2%-1.6% of microcrystalline cellulose (and) sphingomonas fermentation product extract (and) cellulose gum, 2%-5% of butanediol, 0.3%-0.5% of asiaticoside-II, 0.5%-1.5% of centella asiatica, 0.5%-1.5% of vitamin E and the balance of water. And the balance of deionized water. By adding micro-crystalline cellulose (and) sphingomonas fermentation extract (and) cellulose gum, system stability under compounding of five organic acids is realized, semitransparent gelatinous texture is obtained, the composition is suitable for point coating use mode, impression is not affected, oil-controlling and acne-removing effects are improved under the condition of low organic acid content, and the composition belongs to skin-care polyacid products and has a broad market prospect. The mild oil control and acne removal effects are realized, and the cream is suitable for oil-sensitive skin crowds.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and particularly relates to a multi-acid composite oil-control and acne-removing gel and a preparation method thereof. Background Art

[0002] In the field of skin care products, organic acids usually can play roles such as inhibiting sebum secretion, reducing the number of Propionibacterium acnes, and alleviating local inflammation. However, organic acids are prone to precipitate crystals, difficult to be formulated with other active ingredients, have limitations in use, and have irritation problems. Since the 1990s, α-hydroxy acids (fruit acids, abbreviated as AHA) have been applied in skin care products, which has attracted attention to the application of organic acids in skin care products; subsequently, more types of organic acids have been gradually introduced into skin care product formulations, such as salicylic acid, mandelic acid, and lactobionic acid. The evolution of this multi-acid formulation reflects the pursuit of the skin care product industry for more precise and multi-functional skin care solutions; in recent years, with the improvement of consumers' requirements for the effects and safety of skin care products, higher requirements have been put forward for multi-acid skin care product technology.

[0003] Currently, the "organic acid" products on the market are mainly divided into two categories: medical grade (medical acid peeling) and skin care grade (daily acid peeling). There are significant differences between the two in terms of the concentration of organic acid components, usage scenarios, and effects. Specifically: the addition amount of organic acids in medical grade products is very high, with irritation problems. Although the effects are obvious, they need to be used strictly under the guidance of a doctor, with great limitations; although skin care grade products can be used daily and are relatively convenient to use, the addition amount of their organic acids is strictly limited (the total concentration of α-hydroxy acids ≤ 6%, and the concentration of salicylic acid in leave-on cosmetics ≤ 2%), and the usage effects are limited. Therefore, how to improve the oil-control and acne-removing effects of skin care grade multi-acid products while considering the mildness of the products, and meet the needs of different skin types and usage scenarios (especially for oily and sensitive skin, it is necessary to avoid excessive irritation and damage to the skin barrier while controlling oil and removing acne) is a new challenge currently faced by skin care grade multi-acid products. In addition, in recent years, consumers have higher and higher requirements for the texture and usage experience of products. For skin care grade multi-acid products, how to achieve the stable and uniform non-precipitation of organic acids without using traditional emulsifying thickeners, and obtain a semi-transparent gel texture with moderate viscosity for convenient spot treatment of acne is also a new challenge currently faced by skin care grade multi-acid products.

[0004] Patent CN118975952A provides an organic acid thermosensitive gel and its preparation method and application, which uses poloxamer 407 with a hydrophobic core-hydrophilic shell structure as a matrix, is stable to acid, alkaline aqueous solution and metal ions, can encapsulate or dissolve hydrophobic raw materials such as salicylic acid, has a clear and transparent appearance, and has stable viscosity after long-term placement. Based on the reverse thermal reversible properties of poloxamer, the active molecules encapsulated in the micelles are slowly and continuously released by using the temperature increase, thereby minimizing skin irritation. However, the organic acid thermosensitive gel uses a large amount of poloxamer 407, and the production cost is relatively high; moreover, the patent can only prove that it has achieved a stable gel-like texture under the compounding of salicylic acid and fruit acid, and it is impossible to infer whether it is suitable for the compounding of more types of organic acids; in addition, the amount of organic acid added exceeds the limited range of cosmetic regulations, and it needs to be used under the guidance of a doctor, and is not suitable for use as a daily care cosmetic.

[0005] Patent CN115645323A provides an acne-removing and oil-controlling composition containing five acids and a preparation method thereof, which achieves acne-removing and oil-controlling effects by combining multiple acid components with functional extracts; however, the texture of the product is an essence milk, not a translucent gel-like texture, which is not friendly to use on local acne and will affect the appearance after spot application.

[0006] Patent CN117771119A provides an acid-containing acne-removing body lotion and a preparation method thereof, which includes a composite acid, a soothing agent and an emulsifier, wherein the composite acid includes α-hydroxy acid, salicylic acid and its derivatives and hydroxyethylpiperazine ethane sulfonic acid, and the soothing agent includes dipotassium glycyrrhizinate and sea fennel fermentation liquid. The acne-removing body lotion can be applied over a large area, has strong targeting, is safe and efficient, but the formula contains a traditional emulsifier, and the product texture is a lotion texture, which may affect the appearance after spot application, and is less comfortable for people with oily skin, and may be irritating to the face.

[0007] Patent CN118750421A provides a moisturizing and repairing acne skin gel and a preparation method thereof, wherein salicylic acid and fruit acid are processed by fermentation and modification methods to prepare the gel. The prepared gel has the effect of removing acne and acne marks, and is safe and non-irritating; however, since it involves the modification of raw materials, it may be restricted by regulations, and the product is difficult to market.

[0008] In summary, due to the strong irritation of organic acids, and the low pH value of the organic acid system, the complex ion types and strong ionicity, it is difficult to thicken and stabilize the system and obtain a translucent gel-like texture. Therefore, it is a technical problem that needs to be solved urgently to develop a skin care grade multi-acid product that is suitable for people with oily and sensitive skin and suitable for spot application to effectively remove acne locally. Summary of the invention

[0009] The present invention provides a polyacid composite oil-control and acne-removing gel and a preparation method thereof. By adding microcrystalline cellulose, Sphingomonas fermentation extract, and cellulose gum, the polyacid composite oil-control and acne-removing gel achieves system stability under the compounding of five organic acids, obtains a translucent gel texture, is suitable for spot application, does not affect the appearance, and moreover, it improves the oil-control and acne-removing effect at a low organic acid content. It belongs to a skin-care grade polyacid product with low irritation, realizes mild oil-control and acne-removing, and is suitable for people with oily and sensitive skin.

[0010] The present invention provides a polyacid composite oil-control and acne-removing gel, which comprises the following components in percentage by mass: 2% of salicylic acid, 3% - 4% of glycolic acid, 0.5% - 1.5% of mandelic acid, 0.5% - 1.0% of lactic acid, 0.5% - 1.0% of glucono delta-lactone, 1.2% - 1.6% of microcrystalline cellulose, Sphingomonas fermentation product extract, and cellulose gum, 2% - 5% of butanediol, 0.3% - 0.5% of asiaticoside-II, 0.5% - 1.5% of Shifu Jun, and the balance being deionized water.

[0011] In some embodiments, it comprises the following components in percentage by mass: 2% of salicylic acid, 4% of glycolic acid, 1% of mandelic acid, 0.5% of lactic acid, 0.5% of glucono delta-lactone, 1.5% of microcrystalline cellulose, Sphingomonas fermentation product extract, and cellulose gum, 4% of butanediol, 0.5% of asiaticoside-II, 1.5% of Shifu Jun, and the balance being deionized water.

[0012] In some embodiments, the polyacid composite oil-control and acne-removing gel further comprises the following components in percentage by mass: 3% - 5% of plant acne-removing factor, 2% - 4% of PLANT 21N.

[0013] In some embodiments, the polyacid composite oil-control and acne-removing gel further comprises the following components in percentage by mass: 5% of plant acne-removing factor, 2% of PLANT 21N.

[0014] In some embodiments, the polyacid composite oil-control and acne-removing gel further comprises a pH regulator, and the pH of the polyacid composite oil-control and acne-removing gel is 4 - 5.

[0015] In addition, the present invention also provides a preparation method of the polyacid composite oil-control and acne-removing gel according to any one of the above technical solutions, which comprises the following steps:

[0016] Prepare an emulsifying thickener pre-dispersed phase: Disperse microcrystalline cellulose, Sphingomonas fermentation product extract, and cellulose gum in butanediol, and stir until completely wet to obtain the emulsifying thickener pre-dispersed phase;

[0017] Preparation of aqueous phase: Take a part of deionized water and heat it up. Dissolve asiaticoside-II in deionized water and stir until the material is completely dissolved to obtain an aqueous phase in a transparent and homogeneous state.

[0018] Preparation of hydrogel phase: Mix the pre-dispersed phase of the emulsifying thickener and the aqueous phase, and stir and homogenize until the material is uniform and particle-free to obtain hydrogel phase a.

[0019] Addition of organic acids: Dissolve salicylic acid, glycolic acid, mandelic acid, lactobionic acid, and glucono delta-lactone in the remaining deionized water, stir until completely dissolved and adjust the pH to obtain a mixed solution of organic acids. Add the mixed solution of organic acids to hydrogel phase a and stir evenly to obtain hydrogel phase b.

[0020] Addition of soothing and anti-inflammatory components: Initially cool hydrogel phase b, and add Shancare to hydrogel phase b and stir evenly.

[0021] Discharging: After homogenization, cool down to room temperature and discharge.

[0022] In some of these embodiments, the step of adding soothing and anti-inflammatory components further includes: adding a plant acne-removing factor and PLANT 21N to hydrogel phase b.

[0023] In some of these embodiments, in the step of preparing the aqueous phase, heat up to 65°C to 75°C.

[0024] In some of these embodiments, in the step of adding soothing and anti-inflammatory components, initially cool hydrogel phase b to below 35°C.

[0025] In some of these embodiments, in the step of adding organic acids, adjust the pH to 4 - 5 by adding a pH regulator.

[0026] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows:

[0027] 1. The multi-acid composite oil-control and acne-removing gel provided by the present invention uses butanediol as a solvent to dissolve microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum, and then combines with five organic acids. Thus, the Pickering thickening and emulsifying technology is used to achieve the thickening and stabilization of a strong ionic system under the combination of five organic acids, obtaining a composite acid product with a semi-transparent gel texture, meeting consumers' demands for a refreshing texture of the formula, suitable for spot application, not affecting the appearance, and applicable to local effective acne removal. Moreover, using microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum instead of traditional thickening and emulsifying agents reduces irritation and is suitable for people with oily and sensitive skin.

[0028] 2. The polyoxometalate composite oil-control and acne-removing gel provided by the present invention uses two lipophilic acids, salicylic acid and mandelic acid, to improve the affinity with the skin. It can penetrate deep into the pores along with the skin oil, dredge the pores, remove blackheads and acne, and achieve the effect of whitening and brightening the skin, which is suitable for oily and acne-prone skin. Furthermore, by using three water-soluble acids, glycolic acid, lactic acid, and gluconolactone in combination, it can remove cutin by loosening the connection between keratinocytes. While making the skin softer, it promotes the excretion of melanin, further achieving the effect of brightening the skin tone and removing dullness.

[0029] 3. The polyoxometalate composite oil-control and acne-removing gel provided by the present invention uses three small molecule acids, salicylic acid, glycolic acid, and mandelic acid, which have strong skin penetration and act on the middle and deep epidermis. They can effectively exfoliate the aging cutin layer, thus accelerating the metabolism of the skin. The lactic acid with a large molecular weight acts on the shallow and middle epidermis. Moreover, the use of small molecule acids such as glycolic acid can increase the skin's penetration and absorption of lactic acid. The use of lactic acid can also prevent the excessive exfoliation of cutin by small molecule acids such as glycolic acid. And the high water retention and water absorption of lactic acid can form a gel matrix, which has a protective and soothing effect on inflamed skin. Further, gluconolactone is used in combination. It penetrates slowly into the skin and has a long action time, causing less irritation to the skin. Through the formulation idea of five acids, it regulates the skin's water-oil balance, reduces the irritation of acid products and discomfort reactions such as peeling after use.

[0030] 4. The polyoxometalate composite oil-control and acne-removing gel provided by the present invention, on the basis of using traditional salicylic acid, glycolic acid, and mandelic acid, is combined with mild lactic acid and gluconolactone. Through the compounding of five organic acids within a specific proportion range, and in combination with the soothing and anti-inflammatory components, asiaticoside-II and shanfu jun, it can, while ensuring the oil-control and acne-removing effect, minimize the addition amount of salicylic acid, glycolic acid, and mandelic acid to improve the mildness of the product, achieving a mild and efficient acne-control and oil-control effect. The content of its organic acids meets the content limit requirements of skin-care grade polyacid products, belonging to skin-care grade polyacid products, and can meet the daily acne improvement needs of consumers.

[0031] 5. The preparation method of the polyoxometalate composite oil-control and acne-removing gel provided by the present invention has simple preparation steps, does not require complex equipment and cumbersome technological processes, reduces production costs and energy consumption, is conducive to large-scale industrial production, and has good economy. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a product photo of the polyoxometalate composite oil-control and acne-removing gel provided in Example 4 of the present invention;

[0033] Figure 2The usage effect diagrams show the local application of the polyacid composite oil-control and acne-removing gel provided in Example 4 of the present invention on three subjects. Among them, (a)-(c) are the photos of the first subject at 0h, 24h, and 72h respectively; (d)-(f) are the photos of the second subject at 0h, 24h, and 72h respectively; (g)-(i) are the photos of the third subject at 0h, 24h, and 72h respectively.

[0034] Figure 3 The graph shows the change in the average value of the heme content EI in the acne area of the skin after the local application of the polyacid composite oil-control and acne-removing gel provided in Example 4 of the present invention on the subjects.

[0035] Figure 4 The graph shows the change in the average value of the proportion of the red area in the acne area of the skin after the local application of the polyacid composite oil-control and acne-removing gel provided in Example 4 of the present invention on the subjects. Detailed implementation manners

[0036] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0037] The embodiment of the present invention provides a polyacid composite oil-control and acne-removing gel, which includes the following components by mass percentage: 2% salicylic acid, 3% - 4% glycolic acid, 0.5% - 1.5% mandelic acid, 0.5% - 1.0% lactic acid, 0.5% - 1.0% gluconolactone, 1.2% - 1.6% microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum, 2% - 5% butanediol, 0.3% - 0.5% asiaticoside-II, 0.5% - 1.5% Quorastop, and the balance is deionized water. It should be noted that the commodity name of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum is PEMUPUR START POLYMER; the components of asiaticoside-II specifically include cyclodextrin and Centella asiatica extract, and its English commodity name is Redumatte ASC-II; the components of Quorastop specifically include hydroxypropyl cyclodextrin, dipropylene glycol, Pinus densiflora leaf extract, and Lactobacillus fermented product, and its English commodity name is Quorastop.

[0038] The above-mentioned polyacid compound oil-control and acne-removing gel dissolves microcrystalline cellulose, Sphingomonas ferment extract, and cellulose gum with butanediol as the solvent, and then combines with five organic acids. Thus, the Pickering thickening and emulsification technology is used to achieve the thickening and stabilization of a strong ionic system under the combination of five organic acids, obtaining a compound acid product with a translucent gel texture, meeting consumers' demands for a refreshing texture of the formula, being suitable for spot application without affecting the appearance, and being applicable to local effective acne removal. Moreover, replacing traditional thickening and emulsifying agents with microcrystalline cellulose, Sphingomonas ferment extract, and cellulose gum reduces irritation and is suitable for people with oily and sensitive skin.

[0039] Furthermore, the above-mentioned polyacid compound oil-control and acne-removing gel uses two lipophilic acids, salicylic acid and mandelic acid, to improve its affinity with the skin, penetrate deep into the pores along with the skin oil, dredge the pores, remove blackheads and whiteheads, and achieve the effect of whitening and brightening the skin, being suitable for oily and acne-prone skin. Then, three water-soluble acids, glycolic acid, lactic acid, and gluconolactone, are used in combination. They can remove cutin by loosening the connection between keratinocytes, making the skin softer while promoting the excretion of melanin, and further achieving the effect of brightening the skin tone and removing dullness. Using three small-molecule acids, salicylic acid, glycolic acid, and mandelic acid, which have strong skin penetrability and act on the middle and deep epidermis, can effectively exfoliate the aging cutin layer, thus accelerating the metabolism of the skin, while lactic acid with a large molecular weight acts on the shallow and middle epidermis. And the use of small-molecule acids such as glycolic acid can increase the skin's penetration and absorption of lactic acid. The use of lactic acid can also prevent the excessive exfoliation of cutin by small-molecule acids such as glycolic acid. Moreover, the high water retention and water absorption of lactic acid can form a gel matrix, which has a protective and soothing effect on inflamed skin. Further combining with gluconolactone, which penetrates the skin slowly and has a long action time, causes less irritation to the skin. In short, the above-mentioned polyacid compound oil-control and acne-removing gel adjusts the skin's water-oil balance through the combination idea of five acids, reduces the irritation of acid products and discomfort reactions such as peeling after use.

[0040] In addition, the above-mentioned polyacid compound oil-control and acne-removing gel, on the basis of using traditional salicylic acid, glycolic acid, and mandelic acid, combines mild lactic acid and gluconolactone. Among them, lactic acid, as the third-generation fruit acid, has excellent mildness and is suitable for sensitive skin. And gluconolactone, as a polyhydroxy acid, has a macromolecular structure, can gently exfoliate cutin, moisturize, and have antioxidant properties, being suitable for sensitive skin and skin with damaged barriers. Through the compounding of five organic acids within a specific proportion range and cooperating with the soothing and anti-inflammatory components, asiaticoside-II and Shancare Jun, while ensuring the oil-control and acne-removing effect, the addition amounts of salicylic acid, glycolic acid, and mandelic acid can be reduced to the greatest extent, improving the mildness of the product, achieving the mild and efficient acne-control and oil-control effects. Its organic acid content meets the content limit requirements of skin-care grade polyacid products, belonging to skin-care grade polyacid products, and being able to meet consumers' daily needs for improving acne.

[0041] In a preferred embodiment, it comprises the following components by mass percentage: 2% of salicylic acid, 4% of glycolic acid, 1% of mandelic acid, 0.5% of lactic acid, 0.5% of gluconolactone, 1.5% of microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum, 4% of butanediol, 0.5% of asiaticoside-II, 1.5% of Shanchenjun, and the balance is deionized water. This preferred embodiment further defines the optimal ratio of each component. The polyacid composite oil-control and acne-removing gel obtained under this optimal ratio has a better oil-control and acne-removing effect with lower irritation, and has better stability and appropriate viscosity, providing a better user experience.

[0042] In an alternative embodiment, the polyacid composite oil-control and acne-removing gel further comprises the following components by mass percentage: 3% - 5% of plant acne-removing factor and 2% - 4% of PLANT 21N. This alternative embodiment further adds two soothing and anti-inflammatory components, namely plant acne-removing factor and PLANT 21N, which is beneficial to further improve the mildness and achieve a better anti-inflammatory and acne-removing effect. It should be noted that the specific components of the plant acne-removing factor include extracts of Salix alba bark, Phellodendron amurense bark, and Houttuynia cordata, and its English trade name is Composite remove acne agent EG; PLANT 21N is an English trade name, and its Chinese trade name is Soothing and Repairing Agent N. Its specific components include extracts of Opuntia streptacantha stem, Houttuynia cordata, Chamomilla recutita, Portulaca oleracea, Scutellaria baicalensis root, and Paeonia suffruticosa root bark.

[0043] In a preferred embodiment, the soothing and anti-inflammatory component comprises the following components by mass percentage: 5% of plant acne-removing factor and 2% of PLANT 21N. This preferred embodiment further defines the optimal dosage of the plant acne-removing factor and PLANT 21N, and a better mild anti-inflammatory and acne-removing effect can be obtained under this optimal dosage.

[0044] In an alternative embodiment, the polyacid composite oil-control and acne-removing gel further comprises a pH regulator, and the pH of the polyacid composite oil-control and acne-removing gel is 4 - 5. This alternative embodiment further defines that the polyacid composite oil-control and acne-removing gel further comprises a pH regulator to adjust the pH value of the product, and specifically defines the preferred range of the pH value of the product, which is beneficial to reducing irritation and improving the mildness of the product. It should be noted that the pH regulator can be sodium hydroxide, etc. It should also be noted that the pH of the polyacid composite oil-control and acne-removing gel can be 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, etc.

[0045] In an alternative embodiment, the polyacid composite oil-control and acne-removing gel further comprises a humectant, a preservative and a chelating agent. Among them, the humectant can be betaine; the preservative can be selected from at least one of p-hydroxyacetophenone, 1,2-hexanediol, 1,3-propanediol, pentanediol, ethylhexyl glycerin ether, raspberry ketone and octanoyl hydroxamic acid; the chelating agent can be selected from at least one of disodium EDTA, tetrasodium EDTA, trisodium ethylenediamine disuccinate, sodium phytate and tetrasodium glutamate diacetate. It should be noted that the humectant, preservative and chelating agent are conventional components of skin care products, and conventional dosages can be used.

[0046] The embodiment of the present invention also provides a preparation method of the above polyacid composite oil-control and acne-removing gel, which comprises the following steps:

[0047] Prepare an emulsifying thickener pre-dispersed phase: Disperse microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum in butanediol, and stir until completely wet to obtain an emulsifying thickener pre-dispersed phase;

[0048] Prepare an aqueous phase: Heat a part of deionized water, dissolve asiaticoside-II in deionized water, and stir until the material is completely dissolved to obtain an aqueous phase in a transparent and uniform state;

[0049] Prepare a hydrogel phase: Mix the emulsifying thickener pre-dispersed phase and the aqueous phase, and stir and homogenize until the material is uniform and particle-free to obtain a hydrogel phase a;

[0050] Add organic acids: Dissolve salicylic acid, glycolic acid, mandelic acid, lactic acid and glucono delta-lactone in the remaining deionized water, stir until completely dissolved and adjust the pH to obtain a mixed organic acid solution, and add the mixed organic acid solution to the hydrogel phase a, stir evenly to obtain a hydrogel phase b;

[0051] Add soothing and anti-inflammatory components: Cool the hydrogel phase b initially, and add Shifu Jun to the hydrogel phase b, and stir evenly;

[0052] Discharge: After homogenization, cool to room temperature and discharge.

[0053] The preparation method of the above polyacid composite oil-control and acne-removing gel has simple preparation steps, does not require complex equipment and cumbersome process flows, reduces production costs and energy consumption, is conducive to large-scale industrial production, and has good economy.

[0054] In an alternative embodiment, the step of adding soothing and anti-inflammatory components further comprises: adding a plant acne-removing factor and PLANT 21N to the hydrogel phase b. This alternative embodiment further defines the addition steps of the plant acne-removing factor and PLANT 21N, which is conducive to the cooperation of the two with the organic acid components.

[0055] In a preferred embodiment, in the step of preparing the aqueous phase, the temperature is raised to 65°C to 75°C. This preferred embodiment further specifically defines the temperature increase of the aqueous phase, which is beneficial to the dissolution of asiaticoside-II and the mixing of the aqueous phase and the pre-dispersed phase of the emulsifying thickener. It should be noted that the temperature increase can be 65°C, 66°C, 67°C, 68°C, 69°C, 70°C, 71°C, 72°C, 73°C, 74°C, 75°C, etc.

[0056] In a preferred embodiment, in the step of adding the soothing and anti-inflammatory components, the hydrogel phase b is initially cooled to below 35°C. This preferred embodiment further specifically defines the initial cooling temperature of the hydrogel phase b before adding soothing and anti-inflammatory components such as Shufujun, which can avoid the decomposition of soothing and anti-inflammatory components such as Shufujun at high temperatures and is beneficial to maintaining the activity of the soothing and anti-inflammatory components.

[0057] In a preferred embodiment, in the step of adding the organic acid, the pH is adjusted to 4 - 5 by adding a pH regulator. By adjusting the pH to 4 - 5, it is beneficial to reduce product irritation and improve product mildness. It should be noted that the pH regulator can be sodium hydroxide, etc.

[0058] In order to introduce the polyacid composite oil-control and acne-removing gel and its preparation method provided by the embodiments of the present invention more clearly and in detail, the following will be described in combination with specific embodiments.

[0059] Example 1

[0060] A polyacid composite oil-control and acne-removing gel, comprising the following components by mass percentage: salicylic acid 2%, glycolic acid 4%, mandelic acid 1%, lactobionic acid 0.5%, gluconolactone 0.5%, microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum 1.5%, butanediol 4%, asiaticoside-II 0.5%, Shufujun 1.5%, moisturizer (betaine 2%), appropriate pH regulator (sodium hydroxide), appropriate preservatives (p-hydroxyacetophenone, 1,2-hexanediol and 1,3-propanediol), and the balance is deionized water. The specific dosage of each component is shown in Table 1 for details.

[0061] Table 1 Dosage of each component (mass percentage) in Examples 1 - 3 and Comparative Examples 1 - 7 and test results of eye irritation and acne-removing effect

[0062]

[0063]

[0064] The preparation method of the above polyacid composite oil-control and acne-removing gel is as follows:

[0065] (1) Preparation of the pre-dispersed phase of the emulsifying thickener: Weigh each component of Phase B, disperse microcrystalline cellulose, Sphingomonas fermented product extract, and cellulose gum in butanediol, and stir until completely wetted to obtain the pre-dispersed phase B of the emulsifying thickener;

[0066] (2) Preparation of the aqueous phase: Weigh each component of Phase A, heat deionized water to 75 °C, dissolve p-hydroxyacetophenone, 1,2-hexanediol, and asiaticoside-II in deionized water respectively, and stir until the material is completely dissolved to obtain the transparent and homogeneous aqueous phase A;

[0067] (3) Preparation of the hydrogel phase: Mix the pre-dispersed phase B of the emulsifying thickener and the aqueous phase A, and stir and homogenize until the material is uniform and particle-free to obtain the hydrogel phase a;

[0068] (4) Addition of organic acids: Weigh each component of Phase C, dissolve salicylic acid, glycolic acid, mandelic acid, lactic acid, and glucono-delta-lactone in deionized water, stir until completely dissolved, and add sodium hydroxide to adjust the pH to 4.5 to obtain a mixed solution of organic acids. Add the mixed solution of organic acids to the hydrogel phase a and stir evenly to obtain the hydrogel phase b;

[0069] (5) Addition of soothing and anti-inflammatory components: Weigh each component of Phase D, preliminarily cool the hydrogel phase b to below 35 °C, add each component of Phase D to the hydrogel phase b, and stir evenly;

[0070] (6) Discharging: After homogenization, cool to room temperature and discharge.

[0071] Example 2

[0072] The difference between this example and Example 1 lies in: the dosages of each component are different. For the specific dosages of each component, please refer to Table 1.

[0073] Example 3

[0074] The difference between this example and Example 1 lies in: the dosages of each component are different. For the specific dosages of each component, please refer to Table 1.

[0075] Comparative Example 1

[0076] The difference between this comparative example and Example 1 lies in: under the condition of keeping the total content of organic acids unchanged, a compound of three organic acids, namely salicylic acid, glycolic acid, and lactic acid, is used. For the specific dosages of each component, please refer to Table 1.

[0077] Comparative Example 2

[0078] The difference between this comparative example and Example 1 lies in: under the condition of keeping the total content of organic acids unchanged, a compound of three organic acids, namely salicylic acid, glycolic acid, and mandelic acid, is used. For the specific dosages of each component, please refer to Table 1.

[0079] Comparative Example 3

[0080] The difference between this comparative example and Example 1 is that: on the premise of keeping the total content of organic acids unchanged, four organic acids, namely salicylic acid, glycolic acid, mandelic acid and gluconolactone, are compounded, and the specific dosage of each component is shown in Table 1 in detail.

[0081] Comparative Example 4

[0082] The difference between this comparative example and Example 1 is that: on the premise of keeping the total content of organic acids unchanged, four organic acids, namely salicylic acid, glycolic acid, mandelic acid and lactobionic acid, are compounded, and the specific dosage of each component is shown in Table 1 in detail.

[0083] Comparative Example 5

[0084] The difference between this comparative example and Example 1 is that: on the premise of keeping the total content of organic acids unchanged, the ratio of the five organic acids is different.

[0085] Comparative Example 6

[0086] The difference between this comparative example and Example 1 is that: the soothing and anti-inflammatory components asiaticoside-II and Shancare are not added.

[0087] Comparative Example 7

[0088] The difference between this comparative example and Example 2 is that: the soothing and anti-inflammatory components asiaticoside-II and Shancare are not added.

[0089] Eye irritation test and acne treatment effect test

[0090] The products prepared in Examples 1-3 and Comparative Examples 1-7 were subjected to eye irritation test and acne treatment effect test, and the results are shown in Table 1. It can be seen from Table 1 that: by comparing Examples 1-3 and Comparative Examples 1-5, it can be seen that in Examples 1-3 of the present invention, five organic acids compounded in a specific ratio can reduce the irritation of the product while ensuring the oil control and acne treatment effects; by comparing Example 1 and Comparative Example 6, and Example 2 and Comparative Example 7, it can be seen that in Examples 1 and 2 of the present invention, by adding soothing and anti-inflammatory components and compounding with five organic acids, the irritation of the product can be further reduced.

[0091] Example 4

[0092] The difference between this example and Example 1 is that it further includes: 5% of plant acne treatment factor, 2% of PLANT 21N and 0.05% of chelating agent (disodium EDTA). The specific dosage of each component is shown in Table 2 in detail. During preparation, the chelating agent is added after the deionized water is heated up in the step of preparing the aqueous phase; the plant acne treatment factor and PLANT 21N are added to the hydrogel phase b together with Shancare in the step of adding soothing and anti-inflammatory components. The product photo obtained by preparing this example is as Figure 1 shown.

[0093] Local spot application acne treatment effect test

[0094] The multi-acid composite oil-control and acne treatment gel product prepared in Example 4 was spot-applied to the facial acne of the subjects, once in the morning and once in the evening every day for 3 consecutive days. Among them, the usage effects of 3 subjects are as Figure 2 shown. It can be seen that after using the multi-acid composite oil-control and acne treatment gel product prepared in Example 4 of the present invention, the recovery of local acne of the subjects has been significantly improved.

[0095] The skin red area and heme conditions of 7 subjects were detected by a professional skin detector, Visa skin detector, at 0h, 24h, and 72h after using the multi-acid composite oil-control and acne treatment gel product prepared in Example 4. The data were statistically analyzed to obtain a change graph of the average value of the heme content EI in the skin acne area ( Figure 3 ) and a change graph of the average value of the proportion of the red area in the skin acne area ( Figure 4 ). The detection process of the skin red area and heme is as follows: After the subjects treated their facial skin according to the requirements of the experiment, under the guidance of the Visa operator, they gently placed their heads in the designated area of the instrument, and after keeping still, the operator took pictures for collection. The heme index and red area data were recorded by analyzing the facial photos of the subjects collected through the professional software supporting the instrument. From Figure 3 and Figure 4 it can be seen that after using the multi-acid composite oil-control and acne treatment gel product prepared in Example 4 of the present invention, as the number of uses increases, the red area of the subjects significantly decreases and the anti-inflammatory effect is remarkable.

[0096] Example 5

[0097] The difference between this example and Example 4 is that the dosages of each component are different. The specific dosages of each component are shown in Table 2.

[0098] Example 6

[0099] The difference between this example and Example 4 is that the dosages of each component are different. The specific dosages of each component are shown in Table 2.

[0100] Comparative Example 8

[0101] The difference between this comparative example and Example 4 is that silylated silica and potassium hydroxide are used instead of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum.

[0102] Comparative Example 9

[0103] The difference between this comparative example and Example 4 is that starch octenyl succinate aluminum is used instead of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum.

[0104] Comparative Example 10

[0105] The difference between this comparative example and Example 4 is that tapioca starch / polymethylsilsesquioxane is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0106] Comparative Example 11

[0107] The difference between this comparative example and Example 4 is that sodium octenyl succinate starch is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0108] Comparative Example 12

[0109] The difference between this comparative example and Example 4 is that poloxamer 407 is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0110] Comparative Example 13

[0111] The difference between this comparative example and Example 4 is that ZEN is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0112] Comparative Example 14

[0113] The difference between this comparative example and Example 4 is that hydroxyethyl cellulose is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0114] Comparative Example 15

[0115] The difference between this comparative example and Example 4 is that microcrystalline cellulose is used instead of microcrystalline cellulose (and) Sphingomonas fermentate extract (and) cellulose gum.

[0116] Table 2 Dosages (mass percentage) of each component in Examples 4 - 6 and Comparative Examples 8 - 15 and product texture

[0117]

[0118]

[0119]

[0120] Product texture and viscosity detection

[0121] Observed the texture of the products prepared in Examples 4 - 6 and Comparative Examples 8 - 15, and detected the viscosity of the products. The results are shown in Table 2. Among them, the viscosity test method is as follows: After placing the prepared product in a constant temperature incubator at 25°C for 12 hours, use a Brookfield / RVDV2T viscometer to test the viscosity of the product. The test conditions are: Use a 92# viscometer rotor, the rotation speed is 20 rpm, and the test time is 1 min. As can be seen from Table 2, compared with Comparative Examples 8 - 15, the products prepared in Examples 4 - 6 of the present invention have a semi - transparent yellow gel texture and have a moderate viscosity, which is suitable for local spot application for acne treatment.

[0122] Example 7

[0123] The difference between this example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0124] Example 8

[0125] The difference between this example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0126] Example 9

[0127] The difference between this example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0128] Comparative Example 16

[0129] The difference between this comparative example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0130] Comparative Example 17

[0131] The difference between this comparative example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0132] Comparative Example 18

[0133] The difference between this comparative example and Example 4 lies in: the dosages of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum are different. The specific dosages of each component are shown in Table 3.

[0134] Table 3 Dosages (mass percentage) of each component and product texture in Example 4, 7 - 8 and Comparative Examples 16 - 18

[0135]

[0136]

[0137] Detection of product texture and viscosity

[0138] Observe the texture of the products prepared in Examples 4, 7 - 8 and Comparative Examples 16 - 18, and detect the viscosity of the products. The results are shown in Table 3. The viscosity test method is the same as above. As can be seen from Table 3, when the dosage of microcrystalline cellulose (and) Sphingomonas ferment extract (and) cellulose gum is in the range of 1.2% - 1.6%, the prepared products have a semi - transparent yellow gel texture, and have moderate viscosity and usage experience, and are suitable for local spot application for acne treatment.

Claims

1. A polyacid composite oil-control and acne-removing gel, characterized in that, It comprises the following components by mass percentage: 2% of salicylic acid, 3% - 4% of glycolic acid, 0.5% - 1.5% of mandelic acid, 0.5% - 1.0% of lactic acid, 0.5% - 1.0% of gluconolactone, 1.2% - 1.6% of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum, 2% - 5% of butanediol, 0.3% - 0.5% of asiaticoside-II, 0.5% - 1.5% of Shinfujun, and the balance being deionized water.

2. The polyoxometalate composite oil-control and acne-removing gel according to claim 1, wherein It comprises the following components by mass percentage: 2% of salicylic acid, 4% of glycolic acid, 1% of mandelic acid, 0.5% of lactic acid, 0.5% of gluconolactone, 1.5% of microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum, 4% of butanediol, 0.5% of asiaticoside-II, 1.5% of Shinfujun, and the balance being deionized water.

3. The polyoxometalate composite oil-control and acne-removing gel according to claim 1 or 2, characterized in that, The polyacid compound oil-control and acne-removing gel further comprises the following components by mass percentage: 3% - 5% of plant acne-removing factor, 2% - 4% of PLANT 21N.

4. The polyoxometalate composite oil-control and acne-removing gel according to claim 3, characterized in that, The polyacid compound oil-control and acne-removing gel further comprises the following components by mass percentage: 5% of plant acne-removing factor, 2% of PLANT 21N.

5. The polyoxometalate composite oil-control and acne-removing gel according to claim 1, wherein The polyacid compound oil-control and acne-removing gel further comprises a pH regulator, and the pH of the polyacid compound oil-control and acne-removing gel is 4 - 5.

6. The preparation method of the polyoxometalate composite oil-control and acne-removing gel according to any one of claims 1-5, characterized in that It includes the following steps: Preparing an emulsifying thickener pre-dispersed phase: dispersing microcrystalline cellulose (and) Sphingomonas fermented product extract (and) cellulose gum in butanediol, and stirring until completely wet to obtain the emulsifying thickener pre-dispersed phase; Preparing an aqueous phase: heating a part of deionized water, dissolving asiaticoside-II in deionized water, and stirring until the material is completely dissolved to obtain an aqueous phase in a transparent and homogeneous state; Preparing a hydrogel phase: mixing the emulsifying thickener pre-dispersed phase and the aqueous phase, and stirring and homogenizing until the material is uniform and particle-free to obtain hydrogel phase a; Adding organic acids: dissolving salicylic acid, glycolic acid, mandelic acid, lactic acid, and gluconolactone in the remaining deionized water, stirring until completely dissolved and adjusting the pH to obtain a mixed solution of organic acids, and adding the mixed solution of organic acids to hydrogel phase a and stirring evenly to obtain hydrogel phase b; Adding soothing and anti-inflammatory components: initially cooling hydrogel phase b, and adding Shinfujun to hydrogel phase b and stirring evenly; Discharging: after homogenization, cooling to room temperature and discharging.

7. The preparation method of the polyoxometalate composite oil-control and acne-removing gel according to claim 6, characterized in that The step of adding soothing and anti-inflammatory components further includes: adding a plant acne-removing factor and PLANT 21N to hydrogel phase b.

8. The preparation method of the polyoxometalate composite oil-control and acne-removing gel according to claim 6 or 7, characterized in that, In the step of preparing the aqueous phase, heating to 65°C - 75°C.

9. The preparation method of the polyoxometalate composite oil-control and acne-removing gel according to claim 6 or 7, characterized in that, In the step of adding soothing and anti-inflammatory components, hydrogel phase b is initially cooled to below 35°C.

10. The preparation method of the polyoxometalate composite oil-control and acne-removing gel according to claim 6 or 7, characterized in that, In the step of adding organic acids, adjusting the pH to 4 - 5 by adding a pH regulator.

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