Traditional Chinese medicine composition for treating appendicitis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating appendicitis and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The capsule is prepared from the following nine herbal medicines in parts by weight: 5 parts of semen coicis, 10 parts of radix astragali, 5 parts of herba patriniae, 5 parts of semen benincasae, 5 parts of radix et rhizoma rhei, 3 parts of cortex moutan, 3 parts of flos carthami, 3 parts of radix glycyrrhizae and 80 parts of radix saposhnikoviae. The preparation method comprises the following steps: cleaning, drying, crushing (120-mesh sieve), and uniformly mixing to prepare the capsule. Wherein the Chinese parsnip herb is a major medicine for treating internal carbuncle, has the effects of regulating qi to relieve pain and eliminating carbuncle, sore and pyogenic infections, and is matched with other medicines to realize the comprehensive curative effects of strengthening the body resistance, dredging the lower part, clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting urination, expelling pus and removing stasis. The medicine can directly reach the focus, can relieve pain and expel pus after being taken within 2-3 hours, radically treats appendicitis, does not relapse, does not need an operation, is suitable for patients with poor whole-body conditions, surgical taboo or surgical refusal, does not have toxic or side effects, breaks through the limitation of traditional treatment, and remarkably improves the success of conservative treatment.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly to a traditional Chinese medicine composition for treating appendicitis and a preparation method thereof. Background Art

[0002] Appendicitis is a common acute abdomen disease in clinical practice. In traditional Chinese medicine, it belongs to the category of "intestinal abscess". The causes are mostly improper diet, emotional disorders, overwork or external pathogen invasion, which lead to abnormal spleen and stomach transportation and transformation, damp-heat obstruction in the intestines, qi stagnation and blood stasis, and finally heat corrodes into pus. Currently, the main clinical treatment methods include: Surgical treatment: Such as laparoscopic or open appendectomy, but there are risks of complications such as incision infection, adhesive intestinal obstruction, and fecal fistula, and long-term recovery is required after surgery.

[0003] Western medicine treatment: Mainly uses antibiotics, but has limited efficacy for suppurative gangrenous and perforated appendicitis, is prone to form periappendiceal abscesses, and long-term use of antibiotics is likely to lead to drug resistance and intestinal flora imbalance.

[0004] Traditional Chinese medicine treatment: Although classic prescriptions such as Dahuang Mudan Decoction and Yiyiren Fuzhi Baijiang Powder have certain curative effects, there are problems such as long treatment courses, slow onset, and complex individualized formulas, which are difficult to meet the modern clinical requirements for convenience and standardization.

[0005] The main defects of the existing technologies are as follows: Surgical treatment has large trauma and is accompanied by irreversible organ damage; Western medicine treatment is prone to recurrence and has poor effects on severe appendicitis; traditional Chinese medicine lacks standardized formulas and has insufficient efficacy stability. Summary of the Invention

[0006] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating appendicitis that treats both the symptoms and the root cause, has a rapid onset, and has no side effects, and solves the problems of large surgical trauma, easy recurrence of Western medicine, and unstable efficacy of traditional Chinese medicine in the existing technologies.

[0007] To solve the above technical problems, according to one aspect of the present invention, the following technical solutions are provided: A traditional Chinese medicine composition for treating appendicitis, which is composed of the following raw materials in parts by weight: 5 - 10 parts of coix seed, 8 - 12 parts of astragalus membranaceus, 4 - 6 parts of patrinia scabiosaefolia, 4 - 6 parts of winter melon seeds, 4 - 6 parts of rhubarb, 2 - 4 parts of moutan bark, 2 - 4 parts of safflower, 2 - 4 parts of liquorice, and 70 - 90 parts of saposhnikovia divaricata.

[0008] As a preferred scheme of the traditional Chinese medicine composition for treating appendicitis described in the present invention, among them, the parts by weight of the raw materials are: 5 parts of coix seed, 10 parts of astragalus membranaceus, 5 parts of patrinia scabiosaefolia, 5 parts of winter melon seeds, 5 parts of rhubarb, 3 parts of moutan bark, 3 parts of safflower, 3 parts of liquorice, and 80 parts of saposhnikovia divaricata.

[0009] As a preferred embodiment of the traditional Chinese medicine composition for treating appendicitis according to the present invention, the weight portion of Epimeredi indica in the composition is 2-3 times the total weight portion of other raw materials.

[0010] As a preferred embodiment of the traditional Chinese medicine composition for treating appendicitis according to the present invention, the composition is made into an oral preparation, a capsule, a tablet or a granule.

[0011] A preparation method of a traditional Chinese medicine composition for treating appendicitis: includes the following steps: S1 Raw material pretreatment: Coix seed, Astragalus membranaceus, Patrinia scabiosaefolia, Benincasa hispida var. chieh-qua, Rheum palmatum, Paeonia suffruticosa, Carthamus tinctorius, Glycyrrhiza uralensis, Epimeredi indica are respectively cleaned and dried. S2 Crushing and screening: In a sterile and dust-free environment, the pretreated raw materials are respectively ground by a traditional Chinese medicine grinder and passed through a 120-mesh sieve to obtain fine traditional Chinese medicine powder. S3 Mixing and preparing the preparation: Mix the fine traditional Chinese medicine powders evenly according to the weight portion ratio to make an oral preparation.

[0012] As a preferred embodiment of the preparation method of the traditional Chinese medicine composition for treating appendicitis according to the present invention, in the step S3, the oral preparation is a capsule, and the specific preparation process is: filling the evenly mixed fine traditional Chinese medicine powder into a capsule shell and encapsulating it to make a capsule.

[0013] As a preferred embodiment of the preparation method of the traditional Chinese medicine composition for treating appendicitis according to the present invention, in the step S1, the drying temperature is 50-70 °C, and the drying time is until the water content of the raw material ≤ 5%.

[0014] Compared with the prior art, the beneficial effects of the present invention are: The present invention has a rapid onset and strong radical cure effect: abdominal pain, fever and other symptoms can be relieved 2-3 hours after taking the medicine, and the inflammation can be completely eliminated in a 7-15-day course of treatment. The total clinical effective rate reaches more than 95%, and the recurrence rate is less than 3%. The double-dose use of Epimeredi indica significantly enhances the effects of regulating qi and relieving pain, dispelling carbuncles and detoxifying, breaking through the limitation of "using promoting diuresis for treating stranguria" in traditional prescriptions, and realizing the triple effects of "eliminating pus, removing stasis and relieving pain". High safety and no side effects: It is formulated with pure natural Chinese herbal medicines. Verified by acute toxicity tests, LD50 > 5000 mg / kg, belonging to the non-toxic level; no abnormal liver and kidney functions and histopathological damage are found in long-term toxicity tests. Standardized production, convenient to use: The preparation process adopts a fixed ratio and a mechanized process, avoiding the individual decoction error of traditional decoctions; the capsule dosage form is convenient to carry and take, meeting the modern clinical needs. Specific embodiments

[0015] To make the purpose, technical solutions and advantages of the present invention clearer, the embodiments of the present invention will be further described in detail below.

[0016] The present invention provides a traditional Chinese medicine composition for treating appendicitis, which solves the problems of large surgical trauma, easy recurrence of western medicine, and unstable curative effect of traditional Chinese medicine in the prior art.

[0017] Example 1: Preparation of Capsules (Preferred Formula) Raw material weighing: Weigh the raw materials according to the following weights: 50 g of Coix Seed, 100 g of Astragalus membranaceus, 50 g of Patrinia scabiosaefolia, 50 g of Benincasa hispida var. chieh-qua, 50 g of Rheum palmatum, 30 g of Paeonia suffruticosa, 30 g of Carthamus tinctorius, 30 g of Glycyrrhiza uralensis, and 800 g of Saposhnikovia divaricata.

[0018] Pretreatment and pulverization: After all the raw materials are washed with running water, they are placed in an oven at 60 °C and dried for 12 hours until the water content < 5%; They are respectively put into a traditional Chinese medicine pulverizer for pulverization, passed through a 120-mesh sieve, and the fine powder is collected.

[0019] Mixing and capsule making: Pour each fine powder into a stainless steel mixing tank and stir for 45 minutes until the color and luster are uniform; Use an automatic capsule filling machine to fill the mixed powder into No. 0 capsule shells, with a filling amount of 0.5 g per capsule, and seal with an aluminum-plastic board.

[0020] Example 2: Preparation of Granules (Alternative Formula) Raw material ratio: 8 parts of Coix Seed, 9 parts of Astragalus membranaceus, 6 parts of Patrinia scabiosaefolia, 4 parts of Benincasa hispida var. chieh-qua, 6 parts of Rheum palmatum, 4 parts of Paeonia suffruticosa, 2 parts of Carthamus tinctorius, 4 parts of Glycyrrhiza uralensis, and 75 parts of Saposhnikovia divaricata.

[0021] Preparation steps: After completing pulverization and screening according to the method of Example 1, add 10% starch paste as a binder, granulate and dry, pass through a 20-mesh sieve, make into granules, and package them in bags, with 10 g per bag.

[0022] Clinical application cases Case 1: A 32-year-old male patient with acute simple appendicitis, with pain and tenderness in the right lower abdomen, body temperature 38.5 °C, and white blood cell count 12×10 9 / L. After taking the capsules of the present invention (4 capsules each time, 3 times a day) for 3 days, the abdominal pain was relieved and the body temperature returned to normal; after continuous administration for 10 days, ultrasound examination showed that the swelling of the appendix subsided and the white blood cell count returned to normal, and there was no recurrence during the 1-year follow-up.

[0023] Case 2: A 45-year-old female patient with acute attack of chronic appendicitis complicated with adhesive intestinal obstruction, unable to tolerate surgery. After treatment with the granules of the present invention (1 bag each time, 2 times a day) for 2 weeks, the symptoms completely disappeared, and CT reexamination showed that the appendix structure was normal and the intestinal tract was unobstructed.

[0024] Although the present invention has been described above with reference to the embodiments, various modifications can be made thereto and components thereof can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the features in the embodiments disclosed in the present invention can be combined with each other in any way, and the exhaustive description of these combinations is not given in this specification only for the consideration of saving space and resources. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A traditional Chinese medicine composition for treating appendicitis, characterized in that, It consists of the following raw materials in parts by weight: 5 - 10 parts of coix seed, 8 - 12 parts of astragalus membranaceus, 4 - 6 parts of patrinia scabiosaefolia, 4 - 6 parts of winter melon seeds, 4 - 6 parts of rhubarb, 2 - 4 parts of moutan bark, 2 - 4 parts of safflower, 2 - 4 parts of liquorice, and 70 - 90 parts of anemarrhena asphodeloides.

2. The traditional Chinese medicine composition for treating appendicitis according to claim 1, wherein, The parts by weight of the raw materials are: 5 parts of coix seed, 10 parts of astragalus membranaceus, 5 parts of patrinia scabiosaefolia, 5 parts of winter melon seeds, 5 parts of rhubarb, 3 parts of moutan bark, 3 parts of safflower, 3 parts of liquorice, and 80 parts of anemarrhena asphodeloides.

3. The traditional Chinese medicine composition for treating appendicitis according to claim 1, wherein, In the composition, the parts by weight of anemarrhena asphodeloides are 2 - 3 times the total parts by weight of the other raw materials.

4. The traditional Chinese medicine composition for treating appendicitis according to claim 1, wherein, The composition is made into an oral preparation, a capsule, a tablet or a granule.

5. A preparation method of a traditional Chinese medicine composition for treating appendicitis as described in any one of claims 1 - 3, characterized in that, It includes the following steps: S1 Raw material pretreatment: Wash and dry coix seed, astragalus membranaceus, patrinia scabiosaefolia, winter melon seeds, rhubarb, moutan bark, safflower, liquorice, and anemarrhena asphodeloides respectively. S2 Crushing and screening: In a sterile and dust - free environment, grind the pretreated raw materials separately with a traditional Chinese medicine grinder and pass through a 120 - mesh sieve to obtain fine traditional Chinese medicine powder. S3 Mixing and preparation: Mix the fine traditional Chinese medicine powders evenly according to the parts - by - weight ratio to make an oral preparation.

6. The preparation method of a traditional Chinese medicine composition for treating appendicitis according to claim 3, wherein, In the step S3, the oral preparation is a capsule, and the specific preparation process is: Load the evenly - mixed fine traditional Chinese medicine powder into a capsule shell and seal it to make a capsule.

7. The preparation method of a traditional Chinese medicine composition for treating appendicitis according to claim 3, characterized in that In step S1, the drying temperature is 50 - 70 °C, and the drying time is until the water content of the raw materials ≤ 5%.