Swim bladder-based bioactive patch for rotator cuff tendon repair and preparation method of swim bladder-based bioactive patch

Through the bioactive patch modified by the fish bladder base and metal-polyphenol network, the problem of insufficient strength and biological activity of existing tendon patches is solved, and the high-intensity and high-biological activity of tendon repair effects are achieved, and the tendon bone interface healing and cell differentiation are promoted.

CN120393121APending Publication Date: 2025-08-01AFFILIATED HOSPITAL OF NANTONG UNIV
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Patent Information

Application Number
CN202510580413.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-07
Publication Date
2025-08-01

AI Technical Summary

Technical Problem

The existing artificial tendon patches are difficult to take into account high strength and high biological activity, resulting in the existence of the middle tendon bone space of the rotator cuff tendon injury repair, long healing cycle, difficult tendon healing or even tearing again.

Method used

The fish bladder substrate is modified through metal-polyphenol network to form a combination of polyphenols and metal ions, and a bioactive patch is prepared, which retains the microstructure of the orientation arrangement of nanomatrix fibers, and toughens through the metal-polyphenol network to form hydrogen bonds and Schiff base reactions. The binding metal ions bind to the phenolic hydroxyl group under weak alkaline conditions to form a uniform metal-polyphenol cross-linking network.

Benefits of technology

It improves the strength and biological activity of the patch, has antibacterial, anti-inflammatory and antioxidant functions, promotes the healing of the tendon bone interface, stimulates cell differentiation, and improves the repair effect of rotator cuff tendons.

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Abstract

The invention provides a swim bladder-based bioactive patch for rotator cuff tendon repair and a preparation method thereof, and relates to the technical field of biological materials.The swim bladder-based bioactive patch is composed of a swim bladder substrate and a metal-phenol toughening network component, has good tensile strength and biological activity and can be used for repairing rotator cuff tendons. The compound can support cell adhesion and proliferation, stimulate differentiation and phenotype maintenance of various cells derived from tendon-bone tissue, and is expected to be used for repairing rotator cuff tendon injury and promoting tendon-bone healing. Besides, the invention provides a preparation method of the swim bladder-based rotator cuff patch, a special microstructure of directionally arranged nano-matrix fibers is reserved, and a metal-phenol network further plays roles in toughening the patch and enhancing the biological activity of the material. Particularly, the metal-network has an active oxygen free radical response function, excessive free radicals at the shoulder joint part can be removed, and metal ions are released, so that the patch has the effects of resisting bacteria, resisting inflammation, resisting oxidation and improving healing.
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