Acites concentrating, filtering and reinfusion system

Abstract

The invention discloses an ascites concentrating, filtering and reinfusion system which comprises an ascites drainage pipeline, a filter, a plasma component separator and an abdominal cavity reinfusion pipeline, the ascites drainage pipeline is communicated with an inlet of the filter and used for conveying ascites to be treated, and a liquid outlet of the filter is communicated with an inlet of the plasma component separator through a first liquid infusion pipeline; the plasma component separator is used for separating and removing harmful components in the concentrated ascites, a bypass side opening of the plasma component separator is communicated with the abdominal cavity back-transfusion pipeline so as to back-transfusion the treated ascites into the abdominal cavity, the multi-intervention treatment principle is achieved, multi-path individualized switching combination is achieved, the removal efficiency of the harmful substances in the ascites is remarkably improved, and the treatment cost is reduced. Meanwhile, macromolecular beneficial or nutrient substances such as albumin are reserved and purified; and then the abdominal omentum majus capillary network is used for slow absorption, so that the risk and high cost caused by venous transfusion after treatment are avoided, the hemodynamics is stable, and the whole treatment system is safer.

Description

Technical Field

[0001] The present invention relates to the technical field of medical device consumables, and particularly to an ascites concentration filtration and reinfusion system. Background Art

[0002] Ascites, as a common complication of end-stage liver diseases (including liver cirrhosis, liver cancer, and liver failure), its formation involves multiple pathological mechanisms, mainly including the synergistic effects of portal hypertension, hypoproteinemia, malnutrition, and inflammatory responses, etc.

[0003] Currently, the traditional treatment methods for ascites include sodium restriction, diuretics, abdominal paracentesis for ascites drainage, simple ascites ultrafiltration and concentration reinfusion, TIPS, liver transplantation, etc. However, the above methods all have different degrees of limitations, such as easy recurrence of ascites after treatment, poor compliance, many complications, high treatment costs, limited liver sources, etc. The existing simple ascites ultrafiltration and concentration reinfusion systems often only remove water through ultrafiltration, only achieving liquid removal and failing to fully remove harmful substances such as fragmented cell components, fibrous tissues, bacteria, cancer cells, endotoxins, etc. in the ascites. As a result, these harmful substances may be concentrated and reinfused into the abdominal cavity, not only creating a good potential environment for the growth of pathogenic bacteria and exacerbating the deterioration of the intra-abdominal environment; moreover, these concentrated harmful substances may be absorbed by the capillary network of the greater omentum in the abdominal cavity, causing a vicious cycle of the internal environment. These technical limitations make it difficult for the existing methods to meet the individualized treatment needs of special types of ascites such as infectious, chylous, and cancerous ascites. In addition, the pipeline layout in the simple ascites ultrafiltration and concentration reinfusion system is messy, the pipelines are prone to being bent, increasing the operation difficulty, and at the same time also increasing the risks such as hospital-acquired infections.

[0004] Therefore, there is an urgent need for a new ascites concentration filtration and reinfusion system to solve the above technical problems. Summary of the Invention

[0005] The present invention aims to solve the above technical problems, that is, to solve the problem that the existing ascites filtration only achieves liquid removal and fails to fully remove harmful substances such as fragmented cell components, fibrous tissues, bacteria, cancer cells, endotoxins, etc. in the ascites. As a result, these harmful substances may be concentrated and reinfused into the abdominal cavity, not only creating a good potential environment for the growth of pathogenic bacteria and exacerbating the deterioration of the intra-abdominal environment; moreover, these concentrated harmful substances may be absorbed by the capillary network of the greater omentum in the abdominal cavity, causing a vicious cycle of the internal environment. And to solve the problem that the pipeline layout in the simple ascites ultrafiltration and concentration reinfusion system is messy, the pipelines are prone to being bent, increasing the operation difficulty, and at the same time also increasing the risks such as hospital-acquired infections.

[0006] For this purpose, the present invention provides an ascites concentration filtration and reinfusion system, which includes a drainage ascites pipeline, a filter, a plasma component separator, and a reinfusion peritoneal cavity pipeline. The drainage ascites pipeline is connected to the inlet of the filter for transporting the ascites to be processed. The filter is used for filtering and concentrating the ascites to be processed. The outlet of the filter is connected to the inlet of the plasma component separator through the first infusion pipeline. The plasma component separator is used for separating and removing harmful components in the concentrated ascites. The bypass side port of the plasma component separator is connected to the reinfusion peritoneal cavity pipeline to reinfuse the processed ascites into the peritoneal cavity. First tube pumps are installed on both the drainage ascites pipeline and the reinfusion peritoneal cavity pipeline.

[0007] In a specific embodiment of the above ascites concentration filtration and reinfusion system, the ascites concentration filtration and reinfusion system further includes a hemoadsorption device and two second infusion pipelines. One end of one second infusion pipeline is connected to the first infusion pipeline, and the other end is connected to the inlet of the hemoadsorption device. One end of the other second infusion pipeline is connected to the outlet of the hemoadsorption device, and the other end is connected to the first infusion pipeline. Line clamps are installed on both second infusion pipelines, the first infusion pipeline between the two second infusion pipelines, the drainage ascites pipeline, and the reinfusion peritoneal cavity pipeline.

[0008] In a specific embodiment of the above ascites concentration filtration and reinfusion system, the ascites concentration filtration and reinfusion system further includes an integrated panel. The drainage ascites pipeline, the first infusion pipeline, and the reinfusion peritoneal cavity pipeline are all clamped on the integrated panel according to a set path.

[0009] In a specific embodiment of the above ascites concentration filtration and reinfusion system, liquid collection pots are provided on the drainage ascites pipeline, the first infusion pipeline, and the reinfusion peritoneal cavity pipeline. A plurality of first card slots and a plurality of second card slots are provided on the integrated panel. The drainage ascites pipeline, the first infusion pipeline, and the reinfusion peritoneal cavity pipeline are all clamped on the integrated panel through the first card slots, and the liquid collection pots are clamped on the integrated panel through the second card slots.

[0010] In a specific embodiment of the above ascites concentration filtration and reinfusion system, the waste liquid port of the plasma component separator is connected to a waste liquid collection bag. The ascites concentration filtration and reinfusion system further includes a waste liquid recirculation filtration pipeline. One end of the waste liquid recirculation filtration pipeline is communicated with the waste liquid collection bag, and the other end is connected to the inlet of the plasma component separator. A second tube pump is installed on the waste liquid recirculation filtration pipeline.

[0011] In a specific embodiment of the above ascites concentration filtration and reinfusion system, the filter is a hemofiltration device.

[0012] In a specific embodiment of the above ascites concentration filtration and reinfusion system, the filter is a hemodialysis device.

[0013] In the specific implementation manner of the above-mentioned ascites concentration filtration and reinfusion system, an external discharge port is provided on the liquid collection pot, and a pressure monitor is connected thereto. A line clamp is installed on the external discharge port, and the pressure monitor is clamped on the integrated panel.

[0014] In the specific implementation manner of the above-mentioned ascites concentration filtration and reinfusion system, transmembrane pressure detectors are connected to both the filter and the plasma component separator. A side outlet is provided on the drainage abdominal water pipeline, and the side outlet is connected to a graduated PVC intraperitoneal pressure detection pipeline.

[0015] In the specific implementation manner of the above-mentioned ascites concentration filtration and reinfusion system, the waste liquid outlet of the filter is connected to an ultrafiltrate collection bag through an ascites ultrafiltration pipeline. A third tube pump is installed on the ascites ultrafiltration pipeline, and both the ultrafiltrate collection bag and the waste liquid collection bag are connected to a liquid weighing scale with an LED display screen.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. The present invention has multiple intervention treatment principles and multi-path individualized switching combinations, that is, based on the type of ascites, whether to combine a hemoadsorption device is individually selected on the basis of a hemofilter / hemodialyzer and a plasma component separator, significantly improving the removal efficiency of harmful substances in ascites, while retaining and purifying macromolecular beneficial or nutritious substances such as albumin. After treatment, it is slowly absorbed by the capillary network of the greater omentum in the abdominal cavity, avoiding the risks and high costs associated with reinfusion through the vein after treatment, with stable hemodynamics, the entire treatment system being safer, more convenient, and more efficient, good patient compliance and feedback, strong operation repeatability, and the technology being easy to promote and apply.

[0017] 2. The present invention integrates multiple pipelines on the integrated panel according to a set path, preventing the pipelines from being bent, facilitating rapid deployment at the bedside, as well as facilitating the monitoring of the treatment process, improving convenience, the efficiency of installation and removal of the device, reducing the risk of nosocomial infection, and improving the safety of treatment.

[0018] 3. By setting a graduated PVC intraperitoneal pressure detection pipeline, the change in intraperitoneal pressure can be directly and more accurately monitored dynamically, which is beneficial for evaluating the clinical efficacy. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The following describes the preferred implementation manner of the present invention with reference to the accompanying drawings, in which: Figure 1 is the overall structural schematic diagram of the ascites concentration filtration and reinfusion system provided by the present invention; Figure 2 is Figure 1 the structural schematic diagram of the first card slot in Figure 3 is Figure 1Schematic structural diagram of the second card slot.

[0020] List of reference numerals: 1. Filter; 2. Blood adsorber; 3. Plasma component separator; 4. First tube pump; 5. Transmembrane pressure detector; 6. Liquid collection pot; 7. Line clip; 8. Ultrafiltrate collection bag; 9. Waste liquid collection bag; 10. Third tube pump; 11. Pressure monitor; 12. Liquid weighing scale with LED display screen; 13. Drainage abdominal water pipeline; 14. Ascites ultrafiltration pipeline; 15. First infusion pipeline; 16. Second infusion pipeline; 17. Third infusion pipeline; 18. Waste liquid recirculation filtration pipeline; 19. Reinfusion into abdominal cavity pipeline; 20. Scientific research specimen interface; 21. Connection part; 22. Pre-charge pipeline before pump; 23. Second card slot; 24. First card slot; 25. Second tube pump; 26. Integrated panel; 27. Graduated PVC intra-abdominal pressure detection pipeline. Detailed implementation manners

[0021] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some but not all of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the scope of protection of the present invention.

[0022] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by terms such as "upper", "lower", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the system or component referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the use of terms such as "first" and "second" to limit components is only for the convenience of distinguishing the above components. Without further declaration, the above terms have no special meanings and should not be construed as indicating or implying relative importance.

[0023] In the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "set", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0024] The present invention relates to the technical field of medical device consumables, and particularly to an ascites concentrated filtration and reinfusion system. The purpose is to solve the problems that although the existing single ascites ultrafiltration technology can quickly remove the water in ascites to a certain extent, it has problems such as low filtration efficiency, long treatment cycle, and insufficient removal of harmful substances, and is not applicable to infectious and cancerous ascites. For this purpose, the ascites concentrated filtration and reinfusion system (Ascites Concentrated Filtration and Reinfusion System, ACFRS) provided by the present invention includes a drainage ascites pipeline, a filter, a plasma component separator, and a reinfusion peritoneal pipeline. The drainage ascites pipeline is communicated with the inlet of the filter for transporting the ascites to be treated. The filter is used for filtering and concentrating the ascites to be treated. The liquid outlet of the filter is communicated with the inlet of the plasma component separator through the first infusion pipeline. The plasma component separator is used for separating and removing the harmful components in the concentrated ascites. The bypass side port of the plasma component separator is communicated with the reinfusion peritoneal pipeline to reinfuse the treated ascites into the abdominal cavity. The first tube pumps are installed on both the drainage ascites pipeline and the reinfusion peritoneal pipeline. The present invention can individually select a hemodialyzer or a hemofilter according to the nature of ascites to remove excess water and other harmful small and medium-sized molecular substances, and then slowly pass through the plasma component separator to remove harmful components such as endotoxin, bacteria, fragmented red blood cells, fibrous tissue, and larger particle impurities. Finally, the liquid containing beneficial substances (such as albumin) after treatment is reinfused into the patient's body and slowly absorbed by the greater omentum of the abdominal cavity, realizing the effective removal of harmful components and the retention of beneficial components in ascites as a whole, and ensuring the stability and safety of the reinfused components. Next, the ascites concentrated filtration and reinfusion system provided by the embodiments of the present invention will be described in detail with reference to the drawings.

[0025] Refer to Figure 1 , the present invention provides an ascites concentrated filtration and reinfusion system (Ascites Concentrated Filtration and Reinfusion System, ACFRS), including a drainage ascites pipeline 13, a filter 1, a plasma component separator 3, and a reinfusion peritoneal pipeline 19. The drainage ascites pipeline 13 is communicated with the inlet of the filter 1 for transporting the ascites to be treated. The filter 1 is used for filtering and concentrating the ascites to be treated. The liquid outlet of the filter 1 is communicated with the inlet of the plasma component separator 3 through the first infusion pipeline 15. The plasma component separator 3 is used for separating and removing the harmful components in the concentrated ascites. The bypass side port of the plasma component separator 3 is communicated with the reinfusion peritoneal pipeline 19 to reinfuse the treated ascites into the abdominal cavity. The first tube pumps 4 are installed on both the drainage ascites pipeline 13 and the reinfusion peritoneal pipeline 19.

[0026] In the above embodiments, the filter 1 is a hemofiltration filter or a hemodialysis filter, which is selected individually according to the nature of ascites. The first tube pump 4 can be a peristaltic pump. Transmembrane pressure detectors 5 are connected to both the filter 1 and the plasma component separator 3 to detect the transmembrane pressure, and the flow rate is adjusted according to the pressure condition to prevent the filter 1 and the plasma component separator 3 from being blocked and damaged.

[0027] In the above embodiments, line clamps 7 are installed on both the abdominal drainage pipeline 13 and the peritoneal reinfusion pipeline 19. A pre-pump priming pipeline 22 is installed between the line clamp 7 and the first tube pump 4 for dredging the entire pipeline before abdominal treatment. A side outlet is provided on the abdominal drainage pipeline 13, and the side outlet is connected to a graduated PVC intraperitoneal pressure detection pipeline 27. Specifically, a tee is provided on the abdominal drainage pipeline between the line clamp and the pre-pump priming pipeline, and one port of the tee is the side outlet. By providing a graduated PVC intraperitoneal pressure detection pipeline, the change of intraperitoneal pressure can be directly and more accurately monitored dynamically, which is beneficial to evaluating the clinical efficacy.

[0028] Liquid collection pots 6 are provided on both the abdominal drainage pipeline 13, the first infusion pipeline 15 and the peritoneal reinfusion pipeline 19. The liquid collection pot 6 is provided with an external discharge port and is connected with a pressure monitor 11 and the external discharge port, and a line clamp 7 is installed on the external discharge port.

[0029] In addition, the connection between the abdominal drainage pipeline 13 and the inlet of the filter 1, the connection between the first infusion pipeline 15 and the liquid outlet of the filter 1, the connection between the inlet of the plasma component separator 3 and the first infusion pipeline 15, and the connection between the liquid outlet and the peritoneal reinfusion pipeline 19 are all detachable, which is convenient for replacement.

[0030] In one embodiment, continue to refer to Figure 1 , the ascites concentration filtration and reinfusion system further includes a hemoadsorption filter 2 and two second infusion pipelines 16. One end of one second infusion pipeline 16 is connected to the first infusion pipeline 15, and the other end is connected to the inlet of the hemoadsorption filter 2. One end of the other second infusion pipeline 16 is connected to the liquid outlet of the hemoadsorption filter 2, and the other end is connected to the first infusion pipeline 15. Line clamps 7 are installed on both second infusion pipelines 16 and on the first infusion pipeline 15 between the two second infusion pipelines 16.

[0031] In the above embodiments, whether to combine the hemoadsorption filter 2 is selected individually based on the hemofiltration filter / hemodialysis filter and the plasma component separator 3.

[0032] In one embodiment, refer to Figure 1, the waste liquid outlet of the plasma component separator 3 is connected to the waste liquid collection bag 9 through the third infusion pipeline 17. The ascites concentration filtration and reinfusion system further includes a waste liquid recirculation filtration pipeline 18. One end of the waste liquid recirculation filtration pipeline 18 communicates with the waste liquid collection bag 9, and the other end is connected to the inlet of the plasma component separator 3. A second tube pump 25 is installed on the waste liquid recirculation filtration pipeline 18. The second tube pump 25 can be a peristaltic pump.

[0033] The specific working process of this application is as follows: the ascites to be purified is transported to the filter 1 through the first tube pump 4 on the drainage ascites pipeline 13, and the ascites is ultrafiltered through the filter 1 (blood filter or hemodialyzer) to remove inflammatory factors and harmful small molecule substances in the ascites. At the same time, excess water is removed by ultrafiltration concentration. Then, the filtered and concentrated ascites flows into the first infusion pipeline 15 through the liquid outlet of the filter 1, and directly enters the plasma component separator 3 through the first infusion pipeline 15 or enters the blood adsorber 2 and then enters the plasma component separator 3. For example, first enter the blood adsorber 2, and the filtered and concentrated ascites undergoes secondary purification through the blood adsorber 2. The blood adsorber 2 removes potential medium and large molecule harmful substances through broad-spectrum adsorption; the ascites after secondary purification enters the plasma component separator 3 through the first infusion pipeline 15 to complete the third purification, and harmful components such as broken cell components, fibrous tissues, bacteria, cancer cells, and endotoxins in the ascites after ultrafiltration concentration and adsorption are removed, and then are reinfused into the abdominal cavity through the reinfusion abdominal cavity pipeline 19 and slowly absorbed by the huge capillary network in the greater omentum. The waste liquid entering the waste liquid collection bag 9 can be recirculated and filtered again through the waste liquid recirculation pipeline, which helps to filter the waste liquid again and reduce the loss of beneficial components.

[0034] This application uses a combination of multi-stage membranes and adsorption materials to remove endotoxins, bacteria, broken cells, and large molecule toxins, and at the same time retains nutritional components such as albumin to the greatest extent. Dynamically select the combination of ultrafiltration, adsorption, filtration, and cell separation according to the type of ascites, with higher efficiency.

[0035] In one embodiment, the ascites concentration filtration and reinfusion system further includes an integrated panel 26, and the drainage ascites pipeline 13, the first infusion pipeline 15, and the reinfusion abdominal cavity pipeline 19 are all clamped on the integrated panel 26 according to a set path. Regarding the set path, this application does not make specific limitations. Exemplarily, as Figure 1 shown in the pipeline layout, the specific layout method is flexibly set according to the actual use occasion. Integrate multiple pipelines on the integrated panel 26 according to the set path, prevent the pipelines from being folded, facilitate rapid deployment beside the bed, and facilitate the monitoring of the treatment process, improve convenience, the efficiency of installation and removal of the machine, reduce the risk of nosocomial infection, and improve the safety of treatment.

[0036] Specifically, a plurality of first card slots 24 and a plurality of second card slots 23 are provided on the integrated panel 26. The drainage peritoneal fluid pipeline 13, the first infusion pipeline 15, and the reinfusion peritoneal cavity pipeline 19 are all clamped on the integrated panel 26 through the first card slots 24, and the liquid collection pot 6 and the pressure monitor are both clamped on the integrated panel 26 through the second card slots 23. A connecting portion 21 for fixing the panel is provided on the integrated panel 26. For example, the connecting portion 21 is a card slot structure. During use, the integrated panel 26 is clamped at a specified position to ensure that the integrated panel 26 remains fixed during use. The number and arrangement positions of the first card slots 24 and the second card slots 23 are not specifically limited in this application and can be flexibly set according to actual use conditions.

[0037] More specifically, referring to Figure 2 and Figure 3 , both the first card slot 24 and the second card slot 23 are circular ring-shaped, and a notch is provided in the first card slot 24 and the second card slot 23 to facilitate inserting the corresponding pipeline into the first card slot 24 and inserting the liquid collection pot 6 into the second card slot 23. Connecting the pipeline and the liquid collection pot 6 to the integrated panel 26 in this clamping manner is convenient for installation and disassembly, simple to operate, and improves the replacement efficiency. In one embodiment, the waste liquid port of the filter 1 is connected to the ultrafiltrate collection bag 8 through the peritoneal fluid ultrafiltration pipeline 14. A third tube pump 10 is installed on the peritoneal fluid ultrafiltration pipeline 14. Both the ultrafiltrate collection bag 8 and the waste liquid collection bag 9 are connected to the liquid weighing scale 12 with an LED display screen. The third tube pump 10 can be a peristaltic pump.

[0038] In this application, the liquid weighing scale 12 with an LED display screen can weigh the liquids in the ultrafiltrate collection bag 8 and the waste liquid collection bag 9. Research specimen interfaces 20 are provided on the drainage peritoneal fluid pipeline 13, the first infusion pipeline 15, and the reinfusion peritoneal cavity pipeline 19 for purposes such as improving the positive rate of microbial culture, drug sensitivity testing, and tumor gene vaccine research and development in the future.

[0039] This application is a combination that individually selects whether to combine a hemoadsorption device based on a hemofiltration device / hemodialysis device and a plasma separator, which is used to remove excess water and other harmful small and medium-sized molecules, and then slowly passes through the plasma separator to remove harmful components such as endotoxins, bacteria, fragmented red blood cells, fibrous tissues, and large-particle impurities. Finally, the processed liquid containing beneficial substances (such as albumin) is transfused back into the patient's body and slowly absorbed through the greater omentum, achieving the functions of effectively removing harmful components in ascites and retaining beneficial components. The purified beneficial substances such as albumin are transfused back and slowly absorbed, promoting the improvement of the patient's nutrition, immunity, etc. to form a virtuous cycle, ensuring the stability and safety of the transfused components. Compared with the traditional single ultrafiltration system, this technical system has significant advantages, can improve the patient's treatment compliance, reduce the recurrence rate, and effectively reduce the medical cost. The present invention is a peritoneal-to-peritoneal transfusion, which is safer in operation, has better patient compliance, better operational repeatability, a larger amount of ascites cleared per single treatment and a fast clearance speed, significantly improves the abdominal distension symptoms, and significantly improves related aspects such as sleep and diet, avoiding the adverse reactions caused by intravenous transfusion.

[0040] Traditionally, the treatment methods for ascites mainly include sodium restriction, diuretic treatment, paracentesis, liver transplantation, and bypass surgery, etc. These methods can relieve ascites symptoms to a certain extent, but there are many deficiencies. Sodium restriction and diuretic treatment play a certain role in the early treatment of ascites, but have poor effects on refractory ascites and are often accompanied by side effects such as electrolyte imbalance. Although paracentesis can quickly relieve the abdominal pressure and relieve the patient's symptoms, this method requires frequent operations, has an infection risk, and may cause complications such as hypotension and renal function damage. In addition, paracentesis cannot effectively prevent the recurrence of ascites. When the traditional single ultrafiltration system is used to treat ascites, it cannot remove harmful substances (fibrous tissues, fragmented cells, macromolecular toxins, etc.), but instead concentrates and transfuses this part of harmful substances, increasing the infection risk and thus affecting the treatment effect.

[0041] However, the plasma separator designed in the present invention can remove harmful components such as endotoxins, bacteria, fragmented red blood cells, fibrous tissues, and large-particle impurities in ascites, which is beneficial to the intra-abdominal environment; finally, the processed liquid containing beneficial substances (such as albumin) is transfused back into the patient's body and slowly absorbed through the greater omentum, promoting the improvement of the patient's nutrition, immunity, etc. to form a virtuous cycle, and achieving a new balance between retaining beneficial substances and removing toxins. The commonly used types of plasma separators are: Evacure EC-2A, 3A, and 4A types, with membrane pore sizes of 0.01μm, 0.02μm, and 0.03μm respectively, and albumin sieving coefficients of 0.25, 0.65, and 0.75 respectively. The type of plasma separator is selected according to the actual situation.

[0042] The ascites concentration filtration and reinfusion system designed by the present invention can be applied not only to transudative ascites, but also to infectious ascites, chylous ascites, and carcinomatous ascites. It has slow treatment and circulatory reinfusion, with a slow decrease in intra-abdominal pressure and relatively little impact on hemodynamics. Moreover, the amount of ascites removed in a single treatment is relatively large, the abdominal distension symptoms are significantly improved, and related aspects such as sleep and diet are significantly improved. Intra-abdominal pressure can be monitored directly synchronously or intermittently during each treatment process to accurately quantify the immediate and dynamic curative effects.

[0043] In the present invention, the concentrated waste liquid can also be used in research such as microbial culture, drug sensitivity testing, and the development of tumor vaccines. After ascites removal, it is beneficial for clinical digestive endoscopy, abdominal MRI / CT / B-ultrasound examinations. After measuring the waste water and concentrated liquid such as waste cells, combined with the daily intake and output, and directly monitoring the intra-abdominal pressure synchronously or intermittently during each treatment process, it is beneficial for the weight curative effect and weight management of patients with end-stage liver disease complicated with refractory ascites.

[0044] The present invention is significantly superior to the existing ascites treatment systems in terms of structural design, treatment principle optimization, treatment path, safety mechanism, and reuse value. It not only further enhances the treatment effect on the basis of safety, but also has a wide range of adaptability, reasonable price, good patient compliance and feedback, strong operation repeatability, and easy technology promotion and application. The present invention makes a systematic expansion in terms of creativity and application volume, and has significant industrial transformation prospects and good social benefits.

[0045] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit them. Although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the protection scope of the technical solutions of the embodiments of the present invention.

Claims

1. An ascites concentration filtration reinfusion system, characterized in that, It includes a peritoneal drainage pipeline, a filter, a plasma component separator, and a peritoneal reinfusion pipeline. The peritoneal drainage pipeline is connected to the inlet of the filter for transporting the ascites to be processed. The filter is used for filtering and concentrating the ascites to be processed. The liquid outlet of the filter is connected to the inlet of the plasma component separator through the first infusion pipeline. The plasma component separator is used for separating and removing harmful components in the concentrated ascites. The bypass side port of the plasma component separator is connected to the peritoneal reinfusion pipeline to reinfuse the processed ascites into the peritoneal cavity. First tube pumps are installed on both the peritoneal drainage pipeline and the peritoneal reinfusion pipeline.

2. The ascites concentration filtration reinfusion system according to claim 1, wherein The ascites concentration, filtration, and reinfusion system further includes a hemoadsorption device and two second infusion pipelines. One end of one second infusion pipeline is connected to the first infusion pipeline, and the other end is connected to the inlet of the hemoadsorption device. One end of the other second infusion pipeline is connected to the liquid outlet of the hemoadsorption device, and the other end is connected to the first infusion pipeline. Line clamps are installed on both of the two second infusion pipelines, the first infusion pipeline between the two second infusion pipelines, the peritoneal drainage pipeline, and the peritoneal reinfusion pipeline.

3. The ascites concentration filtration reinfusion system according to claim 2, wherein, The ascites concentration, filtration, and reinfusion system further includes an integrated panel. The peritoneal drainage pipeline, the first infusion pipeline, the second infusion pipeline, and the peritoneal reinfusion pipeline are all clamped on the integrated panel according to a set path.

4. The ascites concentration filtration and reinfusion system according to claim 3, characterized in that Liquid collection pots are provided on the peritoneal drainage pipeline, the first infusion pipeline, and the peritoneal reinfusion pipeline. A plurality of first card slots and a plurality of second card slots are provided on the integrated panel. The peritoneal drainage pipeline, the first infusion pipeline, the second infusion pipeline, and the peritoneal reinfusion pipeline are all clamped on the integrated panel through the first card slots. The liquid collection pot is clamped on the integrated panel through the second card slots.

5. The ascites concentration filtration and reinfusion system according to claim 1, wherein The waste liquid port of the plasma component separator is connected to a waste liquid collection bag. The ascites concentration, filtration, and reinfusion system further includes a waste liquid recirculation and filtration pipeline. One end of the waste liquid recirculation and filtration pipeline is connected to the waste liquid collection bag, and the other end is connected to the inlet of the plasma component separator. A second tube pump is installed on the waste liquid recirculation and filtration pipeline.

6. The ascites concentration filtration and reinfusion system according to claim 1, wherein The filter is a hemofiltration device.

7. The ascites concentration filtration and reinfusion system according to claim 1, characterized in that The filter is a hemodialysis device.

8. The ascites concentration filtration reinfusion system according to claim 4, characterized in that, An external discharge port is provided on the liquid collection pot and a pressure monitor is connected. A line clamp is installed on the external discharge port. The pressure monitor is clamped on the integrated panel.

9. The ascites concentration filtration and reinfusion system according to claim 1, wherein, Both the filter and the plasma component separator are connected with transmembrane pressure detectors. A side outlet is provided on the peritoneal drainage pipeline. The side outlet is connected to a graduated PVC intraperitoneal pressure detection pipeline.

10. The ascites concentration filtration and reinfusion system according to claim 5, characterized in that, The waste liquid port of the filter is connected to an ultrafiltrate collection bag through an ascites ultrafiltration pipeline. A third tube pump is installed on the ascites ultrafiltration pipeline. Both the ultrafiltrate collection bag and the waste liquid collection bag are connected to a liquid weighing scale with an LED display screen.

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