Deep brain stimulation equipment capable of realizing explosive stimulation mode

Abstract

The invention relates to deep brain stimulation equipment capable of realizing an explosive stimulation mode, which comprises a deep brain stimulation unit and a deep brain stimulation electrode which are connected through an in-vivo lead. Wherein the deep brain stimulation unit is configured to enable a deep brain stimulation electrode to perform deep brain stimulation nerve regulation and control on a target spot in an explosive stimulation mode with adjustable stimulation parameters. Wherein one or more of group frequency, intra-group frequency and sine wave quantity in a single stimulation period can be adaptively adjusted by the deep brain stimulation unit according to different electrophysiological characteristics of a target point.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a deep brain electrical stimulation device capable of achieving a burst stimulation mode. Background Art

[0002] In recent years, neuromodulation technology has become an important therapeutic approach for treating neurological diseases. Deep brain stimulation, a leading technology in this field, uses precisely implanted electrodes to deliver electrical stimulation to specific brain regions. It has demonstrated significant efficacy in the clinical treatment of movement disorders (such as Parkinson's disease and dystonia), psychiatric conditions (such as refractory depression and obsessive-compulsive disorder), and epilepsy, effectively improving not only clinical symptoms but also significantly enhancing patients' quality of life.

[0003] Currently, deep brain stimulation mainly uses two control modes: open-loop and closed-loop. Open-loop systems use preset fixed stimulation parameters and cannot respond to dynamic changes in neural activity in real time. Although closed-loop systems can dynamically adjust parameters based on neural electrical signals (such as local field potentials), they still face technical bottlenecks in real-time computing power, mode switching efficiency, and long-term stability. These limiting factors directly affect the accuracy and clinical applicability of deep brain stimulation treatment. Although traditional continuous high-frequency electrical stimulation modes can effectively regulate abnormal neural circuits, clinical practice has found that long-term stimulation of neural nuclei may lead to the risk of potential neuronal damage. Therefore, the development of a neuromodulatory device that can apply innovative stimulation modes that can accurately regulate brain circuit disease networks while minimizing side effects has become an important scientific issue and clinical need that urgently needs to be broken through in the current field of neuromodulation.

[0004] The present invention provides a deep brain electrical stimulation device that can achieve a burst stimulation mode. The burst stimulation mode adopts an electrical stimulation paradigm of a short-term high-frequency pulse train, which can highly simulate the physiological neural discharge characteristics. At present, although this stimulation mode has been used in non-invasive neuromodulation technologies such as transcranial magnetic stimulation, there have been no reports of devices with the same technical characteristics in the field of implantable deep brain electrical stimulation. In the early clinical research based on intracranial stereotactic electroencephalography, the team of the present invention preliminarily explored and found that burst stimulation can achieve the same desynchronization effect as traditional stimulation, while showing a longer-lasting therapeutic effect and lower tolerance risk. The research results were published in the form of a paper in the classic journal of neurology. Brain superior.

[0005] This invention fills the gap in the application of burst stimulation technology in the field of deep brain stimulation and has the following outstanding advantages: (1) It pioneered the development of a deep brain stimulation device with a burst stimulation mode that conforms to physiological characteristics; (2) The device can support burst stimulation based on the principle of synaptic plasticity, promoting the functional remodeling of abnormal neural circuits; (3) The device uses a programmable multi-parameter design to support the optimization of individualized treatment plans. This technology provides a safer and more effective solution for deep brain stimulation treatment, with significant clinical application value and broad market prospects.

[0006] In addition, on the one hand, there are differences in understanding among those skilled in the art; on the other hand, the applicant studied a large number of documents and patents when making the present invention, but due to space limitations, not all details and contents are listed in detail. However, this does not mean that the present invention does not have the characteristics of these prior arts. On the contrary, the present invention already has all the characteristics of the prior art, and the applicant reserves the right to add relevant prior art to the background technology. Summary of the Invention

[0007] Currently, the most commonly used deep brain stimulation (DBS) stimulation mode in clinical practice is continuous high-frequency stimulation, such as 130-180 Hz stimulation frequency, 60-90 μs pulse width, and 1-4 mA stimulation intensity. However, there is still room for improvement in these stimulation parameters and stimulation modes.

[0008] The present invention relates to a deep brain electrical stimulation device capable of delivering a burst-based stimulation mode, comprising implantable deep brain stimulation electrodes and a connected deep brain stimulation unit. The deep brain stimulation unit is capable of delivering burst stimulation pulses to target sites via the deep brain stimulation electrodes. This signal consists of alternating stimulation periods and rest periods, with multiple sinusoidal pulses continuously delivered at a group frequency during the stimulation period and pulse output cessation during the rest period. Following multidisciplinary consultation and evaluation by neurology, neurosurgery, imaging, and electrophysiology experts, the stimulation electrodes are precisely implanted along a predetermined path into the patient's target brain area according to an individualized treatment plan. The core innovation of this invention lies in its burst-based stimulation mode, in which various stimulation parameters (including pulse frequency, current intensity, duration, etc.) can be dynamically adjusted based on the physiological characteristics and treatment needs of different brain target areas, enabling precise and personalized neuromodulation therapy. Through this programmable burst-based stimulation mode, the system can provide optimized treatment parameter combinations for different neural circuits and pathological conditions.

[0009] In particular, the deep brain electrical stimulation device of the present invention introduces a burst stimulation mode. The burst stimulation mode, with its unique pulse train delivery method, can reduce energy consumption while improving the specificity and effectiveness of stimulation. By adjusting the stimulation parameters, doctors can provide personalized treatment based on the specific conditions of different patients, thereby achieving the best treatment effect. Among them, the burst stimulation signal generated by the deep brain stimulation unit has an adjustable group frequency and intra-group frequency. The burst stimulation signal can be adaptively adjusted by the deep brain stimulation unit according to the different electrophysiological characteristics of the target point, including one or more of the group frequency, intra-group frequency and the number of sine waves in a single stimulation period.

[0010] According to a preferred embodiment, the deep brain stimulation unit is equipped with a controller. After the medical imaging navigation system completes the positioning of the target point, the controller receives the target point location information and the diagnosis type, and selects the corresponding burst stimulation parameters for the patient based on the clinician's judgment. The controller can adjust the stimulation parameters in the burst stimulation mode according to preset rules. The deep brain stimulation unit can transmit the adjusted stimulation parameters to the deep brain stimulation electrodes via the stimulation output port in the form of stimulation signals with the help of its configured signal generator. The stimulation parameters include group frequency, frequency within a group, number of sinusoids within a group, stimulation duration, rest duration, and number of cycles. The introduction of a wireless transmission module enables the deep brain stimulation unit to receive relevant information about the target point in real time or on demand, including key data such as location, size, morphology, and relationship with surrounding tissues. This instant data exchange ensures the accuracy and dynamic adjustment capability of the treatment process. The controller allows adjustment of stimulation parameters such as group frequency, frequency within a group, number of sinusoids within a group, stimulation duration, rest duration, and number of cycles through a series of preset rules. This adjustment mechanism not only improves the accuracy of treatment, but also reduces discomfort or ineffective stimulation that may be caused by fixed parameter settings, thereby optimizing the treatment effect and patient comfort.

[0011] According to a preferred embodiment, the controller is configured with a channel adjustment module, a frequency adjustment module, and an intensity adjustment module, wherein the channel adjustment module enables the stimulation channel of the deep brain stimulation electrode corresponding to the site; the frequency adjustment module is configured to adjust the group frequency, the frequency within the group, and the number of sine waves within the group in the burst stimulation mode; the intensity adjustment module is configured to adjust the current intensity in the burst stimulation mode. Different frequency adjustments will have different effects on the activation pattern of neurons. The frequency adjustment module can improve the therapeutic effect by flexibly adjusting the rhythm and pattern of stimulation. In addition, the intensity adjustment module can dynamically adjust the intensity of stimulation according to the patient's tolerance and response by adjusting the current intensity in the burst stimulation mode.

[0012] According to a preferred embodiment, a deep brain stimulation unit is capable of generating a burst stimulation signal between two contacts of a deep brain stimulation electrode, electrically stimulating a target site by placing the deep brain stimulation electrode in a burst stimulation mode, wherein the pulses of the burst stimulation mode are cyclically delivered with time intervals. The burst stimulation mode is configured as an intermittent stimulation mode comprising an interval period and a stimulation period, wherein the sum of the stimulation duration of a stimulation period and the rest duration of an interval period is the total duration of a cycle. By introducing the concepts of an interval period and a stimulation period, the burst stimulation mode achieves more precise and dynamic regulation of neural tissue. The electrical stimulation during the stimulation period can directly act on the target neural tissue, triggering a series of physiological and biochemical reactions, thereby regulating the function of the nervous system. The presence of the interval period allows the neural tissue to obtain a certain degree of rest and recovery after stimulation, avoiding fatigue or reduced adaptability that may be caused by continuous stimulation. This alternation of stimulation and rest enables the burst stimulation mode to more effectively stimulate the response potential of the nervous system while reducing unnecessary energy consumption and potential side effects.

[0013] The stimulation parameters include group frequency and intra-group frequency. The group frequency refers to the frequency within a stimulation period, and the intra-group frequency refers to the frequency of the sine wave within a stimulation period. On the one hand, the setting of the group frequency allows macro-adjustment of the stimulation frequency during the entire stimulation period. By adjusting the group frequency, the total number of stimulation pulses per unit time can be controlled, thereby affecting the excitation level and response intensity of the neural tissue. On the other hand, the introduction of the intra-group frequency enables fine control of the internal characteristics of each pulse during the stimulation period. The intra-group frequency determines the waveform and frequency characteristics of the pulse. By adjusting the intra-group frequency, parameters such as the shape, width, and duration of the pulse can be changed, thereby affecting the specific effect of the stimulation signal on the neural tissue (different pulse widths and current intensities have different effects on the cortical evoked points, see Figure 5 ). In this mode, burst stimulation pulses are cyclically released in the form of time intervals. Compared with traditional continuous pulse stimulation, the burst stimulation mode is characterized in that pulses are released in the form of groups, the pulses within the groups are closely connected, and there is a certain time interval between the groups. This pulse release method is more in line with the natural discharge rhythm of neurons, and therefore shows a more superior effect in the treatment of brain circuit diseases of the nervous system. At the same time, this energy-saving feature helps to extend the service life of the equipment, reduce the frequency of battery replacement, and thus reduce the overall cost of treatment. The present invention provides an innovative burst stimulation mode for the optimization and selection of neural regulation parameters, which achieves efficient and energy-saving neural regulation through intermittent pulse release.

[0014] This system supports multiple programmable burst stimulation modes, including theta-burst stimulation (TBS) and adjustable multi-frequency stimulation. TBS is divided into continuous (cTBS) and intermittent (iTBS) modes. According to literature, based on the principles of synaptic plasticity, cTBS can induce long-term depression, reducing cortical excitability, while iTBS can induce long-term potentiation, increasing excitability. The system also supports customizable "X / YHz" parameters, allowing precise setting of the number of pulse clusters per minute and the frequency within a cluster (for example, "3 / 50Hz" indicates three clusters of 50Hz pulses per minute). Technically, an FPGA hardware timer ensures microsecond-level timing accuracy, a dynamic impedance matching circuit maintains current stability, and real-time charge density monitoring ensures treatment safety. This intelligent burst stimulation approach retains the efficacy of traditional methods while significantly improving energy efficiency and safety, providing a more optimized solution for neuromodulation therapy.

[0015] In a preferred embodiment, the pulse parameters of the burst stimulation mode are set by the deep brain stimulation unit to deliver one or more bursts within one minute, and when delivering multiple bursts, the frequency between clusters can be freely adjusted. This variable configuration of the frequency between clusters can simulate the natural oscillation characteristics of biological neural impulses. At the same time, the bursting control within one minute conforms to the metabolic cycle of deep brain nuclei, avoiding the attenuation of stimulation efficacy due to energy depletion.

[0016] According to a preferred embodiment, the burst stimulation mode is configured as an intermittent stimulation mode comprising an interval period and a stimulation period, wherein the sum of the stimulation duration of a stimulation period and the rest duration of an interval period is the total duration of a cycle; the group frequency included in the stimulation parameters refers to the frequency within a stimulation period, and the intra-group frequency included in the stimulation parameters refers to the frequency of the sine wave within a stimulation period. The synergistic effect of the group frequency and the intra-group frequency can reset the neurophysiological state through periodic silent intervals, maintaining the effective transmission of the stimulation signal. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic diagram of a deep brain stimulation unit of the present invention disposed within a patient's body; Figure 2 is a hardware topology diagram of the deep brain stimulation unit of the present invention; Figure 3 is a schematic diagram of stimulation modes achievable by the device of the present invention; Figure 4 The device of the present invention implements the modes of traditional continuous high-frequency stimulation and burst stimulation, and the stimulation effect diagrams; Figure 5 This is a comparison diagram of changes in cortical evoked potentials at different current intensities and pulse widths when the deep brain stimulation unit of the present invention implements a burst stimulation mode; Figure 6 is a schematic diagram of the deep brain stimulation unit of the present invention set to intermittent stimulation mode; Figure 7 It is a schematic diagram of the operation flow of the deep brain stimulation device of the present invention.

[0018] Reference Signs List 100: Deep brain stimulation electrode; 200: Deep brain stimulation unit; 210: Controller; 211: Channel adjustment module; 212: Frequency adjustment module; 213: Intensity adjustment module; 220: Signal generator; 221: Electric pulse generation module; 230: Stimulation output port; 240: Battery module. DETAILED DESCRIPTION

[0019] The following is a detailed description with reference to the accompanying drawings.

[0020] This invention proposes a deep brain stimulation device capable of implementing a burst-based stimulation mode for electrically stimulating target brain points. This device allows for the configuration and adjustment of different stimulation parameters within this burst-based stimulation mode, which offers advantages over traditional electrical stimulation methods, such as greater energy efficiency and less damage.

[0021] Preferably, the deep brain stimulation unit 200 of the present invention can apply a burst stimulation mode to the deep brain stimulation electrode 100 implanted in the target site to perform deep brain stimulation treatment.

[0022] To explore a stimulation mode that is both energy-efficient and intelligent, the present invention has designed a burst stimulation mode. The key feature of this burst stimulation mode is that it delivers pulses in groups over a short period of time, with each group consisting of a continuous stimulation cycle. This pulse delivery method is more consistent with the natural firing rhythm of neurons. Figure 4 The results show a comparison of the inhibitory effects of burst stimulation mode and continuous high-frequency stimulation mode on epileptic discharges (cited from Cheng Y, Wang D, Zhang X, Jin G, Wu D, Wang Q, Du J, Qi L, Xu C, Qiao Z, Wang X, Ge J, Wang S, Yan H, Wang X, ZhangH, Yu T, Wang Y, Yeh FC, Zhao G, Ren L. Structural network-specific effect of extreme capsule stimulation for drug-resistant focal epilepsy. Brain. 2025Mar 21:). Figure 4It can be found that the burst stimulation mode can not only achieve a regulatory effect similar to the continuous high-frequency stimulation currently used in clinical practice, but also achieve this effect at a lower stimulation current intensity, giving the burst stimulation mode a dual advantage: on the one hand, it reduces the risk of neuronal electrical stimulation damage, and on the other hand, it significantly reduces energy consumption and improves the endurance of the stimulation system.

[0023] The deep brain stimulation unit 200 of the present invention can use the target point as the stimulation target point, and the deep brain stimulation unit 200 can apply a burst stimulation mode. Figure 3 As shown in the figure, it includes theta-burst stimulation and 1Hz-burst stimulation. Theta-burst stimulation can be divided into continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation (iTBS) according to whether there is a pause during the stimulation process.

[0024] Continuous TBS (cTBS): The commonly used cTBS protocol involves repeated short pulses of high-frequency (50 Hz) stimulation at 5 Hz (200 ms intervals), without pause, for a total of 600 pulses over a total duration of 40 seconds. By stimulating the cerebral cortex, cTBS can induce a long-term depression (LTD) effect, thereby reducing cortical excitability.

[0025] Intermittent TBS (iTBS): The commonly used iTBS protocol consists of 2 seconds of stimulation followed by 8 seconds of rest, repeated 20 times, for a total of 600 pulses, over a total duration of 190 seconds. By stimulating the cerebral cortex, iTBS can induce long-term potentiation (LTP), thereby increasing cortical excitability.

[0026] 1Hz-burst stimulation: The frequency of the burst stimulation mode of the present invention can be 1 / 50Hz, 1 / 100Hz, 1 / 150Hz, 1 / 175Hz or 1 / 200Hz, which means that one cluster of pulses is emitted per minute, and the frequency within the cluster is 50Hz, 100Hz, 150Hz, 175Hz or 200Hz. Preferably, the burst stimulation mode of the present invention can be freely set to emit any cluster within one minute, rather than being limited to one cluster, and the frequency within the cluster can also be freely adjusted. For example, "1 / 50Hz" means that the pulses are cycled on and off at intervals of 0.8 seconds, and the internal frequency of the burst stimulation mode is 50Hz; "1 / 200Hz" means that the pulses are cycled on and off at intervals of 0.8 seconds, and the internal frequency of the burst stimulation mode is 200Hz.

[0027] Physicians can adjust the burst stimulation mode based on the patient's response and treatment needs, reducing energy consumption while maintaining therapeutic effects.

[0028] Preferably, if Figure 1 、 Figure 2 As shown, the deep brain stimulation unit 200 may include a wireless transmission module, a signal generator 220 , a controller 210 , a stimulation output port 230 , and a battery module 240 .

[0029] Preferably, the controller 210 is configured with a channel adjustment module 211, a frequency adjustment module 212 and an intensity adjustment module 213, wherein the channel adjustment module 211 is configured to enable the stimulation channel of the deep brain stimulation electrode 100 corresponding to a predetermined specific stimulation site based on the site; the frequency adjustment module 212 is configured to adjust the group frequency, the frequency within the group and the number of sine waves within the group in the burst stimulation mode; the intensity adjustment module 213 is configured to adjust the current intensity in the burst stimulation mode.

[0030] Preferably, if Figure 7 As shown, the controller 210 is equipped with a channel adjustment module 211, a frequency adjustment module 212 and an intensity adjustment module 213. These modules are closely connected in hardware structure and function to achieve precise control of deep brain stimulation. The main function of the channel adjustment module 211 is to select and enable the stimulation channel of the deep brain stimulation electrode 100 corresponding to a predetermined specific stimulation site. In addition, the channel adjustment module 211 also outputs an activation signal to the frequency adjustment module 212 and the intensity adjustment module 213 to enhance the stimulation effect and achieve personalized modulation. The frequency adjustment module 212 is responsible for adjusting the group frequency, the frequency within the group and the number of sine waves within the group in the burst stimulation mode. This module sets the frequency of the stimulation group according to the instructions of the controller 210 to optimize the effect and adaptability of the stimulation. It also dynamically adjusts the stimulation frequency of each electrode in the group to ensure the coordination and effectiveness between the electrodes, and adjusts the number of sine waves within the group to make the treatment more flexible and personalized. The intensity adjustment module 213 regulates the current intensity during burst stimulation. Specifically, it precisely adjusts the stimulation current intensity based on patient feedback and treatment needs to accommodate different clinical scenarios. Simultaneously, the module monitors and responds to changes in the patient's physiological state, rapidly adjusting the current intensity to enhance patient comfort and acceptance. It also stores historical treatment parameters and patient feedback to support optimization of future treatment plans.

[0031] Preferably, in order to improve the physiological adaptability of regulation, the system introduces a symptom evolution trend prediction mechanism. All regulation processes display the correlation between the parameter adjustment trajectory and the symptom relief curve through a visual interface. Doctors can manually intervene to adjust the weight distribution of different parameters. For example, in the acute treatment period, priority is given to ensuring efficacy, and in the rehabilitation period, emphasis is placed on comfort optimization, forming a dual protection system of "automatic response-manual calibration".

[0032] Preferably, upon receiving information about the target, the controller 210 of the deep brain stimulation unit 200 activates a pre-set algorithm. This algorithm, which integrates extensive clinical data and experimental research results, automatically analyzes target characteristics and intelligently adjusts various parameters of the burst stimulation mode based on factors such as the patient's specific condition. These parameters are not limited to group frequency, frequency within a group, and number of sine waves within a group, but also include stimulation duration, rest duration, and number of cycles, aiming to achieve personalized and precise treatment effects.

[0033] Preferably, the controller 210 will dynamically adjust the group frequency within the range of 1 to 40 Hz based on factors such as the depth of the target point and the safe distance from adjacent important structures to ensure that the stimulation can effectively cover the target area while avoiding unnecessary interference to the surrounding brain tissue. At the same time, the frequency within the group is flexibly set within a wide range of 50 to 5000 Hz, allowing the generation of high-frequency sine waves that, when combined into burst pulses, can simulate natural neural signals and promote the rebalancing of the neural network. Preferably, the controller 210 will also fine-tune the number of sine waves in the group (1 to 20) based on the treatment goals (such as reducing tremors, improving bradykinesia, etc.) and the patient's immediate feedback to optimize the stimulation effect. Figure 6 As shown in the figure, the settings of stimulation duration and rest duration are based on the physiological effects of the "pulse-rest" cycle, which aims to promote neuroplasticity changes through intermittent stimulation mode while avoiding the adaptability and tolerance problems that may be caused by long-term continuous stimulation.

[0034] Preferably, the adjusted stimulation parameters are converted into precise electrical signals by the signal generator 220 and transmitted to the deep brain stimulation electrodes 100 via the stimulation output port 230. These electrodes are precisely implanted at the target site, and the burst stimulation pattern is set between the two contacts to generate a pulse sequence with specific time intervals, providing precise electrical stimulation to the target site. This stimulation pattern not only effectively alleviates patients' symptoms but also has a low risk of side effects, providing an innovative and effective treatment for neurodegenerative diseases.

[0035] In the specific implementation of the intermittent stimulation mode, each treatment cycle is composed of alternating stimulation periods and interval periods. The duration of the stimulation period is dynamically set according to the response characteristics of the target neural pathway. During this period, the deep brain stimulation electrode 100 continuously emits multiple sinusoidal wave pulses at the group frequency to form a dense pulse sequence; the interval period completely stops the pulse output to provide recovery time for the neural tissue. The total duration of a single complete cycle is determined by the sum of the stimulation period and the interval period. This time parameter is adaptively adjusted according to the different treatment stages. Among them, the setting of the group frequency reflects the frequency of stimulation periods per unit time and is used to control the overall treatment rhythm; the group frequency determines the firing rate of each pulse in a single stimulation period, which directly affects the synchronous activation effect of neurons. By rationally configuring the duration ratio of the stimulation period / interval period and the group frequency parameters, the excitability balance of neural regulation can be optimized while reducing energy consumption.

[0036] It should be noted that the above-mentioned specific embodiments are exemplary, and those skilled in the art can come up with various solutions inspired by the disclosure of the present invention, and these solutions also belong to the disclosure scope of the present invention and fall within the protection scope of the present invention. Those skilled in the art should understand that the present invention specification and its drawings are illustrative and do not constitute a limitation on the claims. The scope of protection of the present invention is defined by the claims and their equivalents. The present invention specification contains multiple inventive concepts, such as "preferably" or "according to a preferred embodiment", which means that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to file a divisional application based on each inventive concept. Throughout the text, the features guided by "preferably" are only an optional method and should not be understood as having to be set, so the applicant reserves the right to abandon or delete the relevant preferred features at any time.

Claims

1. A deep brain electrical stimulation device capable of achieving a burst stimulation mode, comprising a deep brain stimulation electrode (100) implanted in the brain and a deep brain stimulation unit (200) connected thereto, characterized in that: The deep brain stimulation unit (200) is capable of outputting burst stimulation pulses to a target point via the deep brain stimulation electrode (100), wherein the signal is composed of alternating stimulation periods and interval periods, wherein the stimulation period continuously emits a plurality of sinusoidal wave pulses at an intra-group frequency, and the interval period stops the pulse output; The burst stimulation signal generated by the deep brain stimulation unit (200) has an adjustable group frequency and intra-group frequency, and the burst stimulation signal can be adaptively adjusted by the deep brain stimulation unit (200) in terms of one or more of the group frequency, the intra-group frequency, and the number of sine waves in a single stimulation period according to different electrophysiological characteristics of the target point.

2. The electrical stimulation device according to claim 1, wherein The deep brain stimulation unit (200) is equipped with a controller (210). When the medical image navigation system completes the positioning of the target point, the controller (210) receives the target point location information and the diagnosis type, and gives the patient corresponding burst stimulation parameter selection based on the judgment of the clinician; The stimulation parameters include group frequency, frequency within a group, number of sinusoids within a group, current intensity, stimulation duration, rest duration, and number of cycles. The deep brain stimulation unit (200) converts the stimulation parameters into stimulation signals via a signal generator (220), and transmits the signals to the deep brain stimulation electrode (100) via an output port.

3. The electrical stimulation device according to claim 2, characterized in that The controller (210) is configured with a channel adjustment module (211), a frequency adjustment module (212) and an intensity adjustment module (213), wherein the channel adjustment module (211) is configured to enable the stimulation channel of the deep brain stimulation electrode (100) corresponding to a predetermined stimulation site according to the site; the frequency adjustment module (212) is configured to adjust the group frequency, the frequency within the group and the number of sine waves within the group in the burst stimulation mode; and the intensity adjustment module (213) is configured to adjust the current intensity in the burst stimulation mode.

4. The electrical stimulation device according to claim 1, wherein The deep brain stimulation unit (200) is capable of generating a burst stimulation signal between two required contact points on the deep brain stimulation electrode (100), and electrically stimulating the target point by placing the deep brain stimulation electrode (100) in the burst stimulation mode, wherein the pulses of the burst stimulation mode are cyclically emitted in a time interval.

5. The electrical stimulation device according to claim 1, wherein The pulse parameters of the burst stimulation mode are set by the deep brain stimulation unit (200) to be able to emit one or more clusters within one minute, and when multiple clusters are emitted, the frequencies between different clusters can be freely adjusted.

6. The electrical stimulation device according to claim 2, wherein The burst stimulation mode is configured as an intermittent stimulation mode including an interval period and a stimulation period, wherein the sum of the stimulation duration of a stimulation period and the rest duration of an interval period is the total duration of one cycle; The group frequency included in the stimulation parameters refers to the frequency within a stimulation period, and the intra-group frequency included in the stimulation parameters refers to the frequency of the sine wave within a stimulation period.

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