Uniform mixing device and method for cell analyzer

Abstract

The invention discloses a cell analyzer mixing device and a mixing method. The cell analyzer mixing device comprises a device body, a main shaft is rotatably arranged on the device body, a fixing frame is fixed in the device body, a rotating shaft is rotatably arranged on the fixing frame, and the rotating shaft and the main shaft are in transmission connection through a gear transmission mechanism; a stirring rod is fixed to the rotating shaft, a stirring brush is fixed to the stirring rod, a movable frame is movably arranged in the device body, a plurality of clamping rings are fixed to the movable frame, test tubes are movably clamped in the clamping rings, and the movable frame is movably installed on the inner wall of the device body through a clamping assembly; an auxiliary shaft is rotationally arranged on the device main body and is in transmission connection with the main shaft through a belt transmission mechanism; and a plurality of cams are fixed on the auxiliary shaft. The invention relates to the technical field of cell blending devices, in particular to a blending device of a cell analyzer and a blending method, which can fully and effectively blend blood samples and diluents, are simple in structure and low in manufacturing cost, and can be applied to blending operation of common vein blood samples.

Description

Technical Field

[0001] The present invention relates to the technical field of cell mixing devices, in particular to a mixing device and a mixing method for a cell analyzer. Background Art

[0002] Hematology analyzers, also known as blood cell analyzers, hematology analyzers, and blood cell counters, are widely used in clinical laboratory testing in hospitals. One of the key development directions for hematology analyzers is to gradually increase their level of automation to improve the accuracy and convenience of analysis and testing. Common hematology analyzers generally include a sample introduction mechanism, a sampling mechanism, a detection mechanism, a sample return mechanism, and a data transmission device.

[0003] Dilution and mixing of blood samples are essential pre-processing steps for blood cell analysis. Most semi-automatic hematology analyzers lack in-line blood sample dilution and mixing devices, which can result in poor repeatability and low test accuracy. This can also shorten the lifespan of some testing components.

[0004] Patent application CN110398600A discloses an automatic blood sample mixing device and a blood cell analysis device. The mixing device includes a main body and a vibration module. A test tube compartment is provided on the main body, and the vibration module includes a first drive unit, an eccentric block, and a test tube support module. The test tube support module, the first drive unit, and the eccentric block are connected in sequence. The test tube support module is used to support the bottom of the blood sample collection tube to accommodate the blood sample collection tube in the test tube compartment. The first drive unit drives the eccentric block to rotate and drive the test tube support module and the bottom of the blood sample collection tube to swing, so as to mix the blood sample in the blood sample collection tube. The blood cell analysis device includes a mixing device and an automatic feeding device.

[0005] The automatic blood sample mixing device and blood cell analysis equipment provided in the aforementioned patent application are designed for smaller "peripheral blood samples," replacing the traditional manual shaking and mixing of peripheral blood samples. This device is complex in structure and relatively expensive to manufacture, making it unsuitable for mixing common venous blood samples. Therefore, we propose a mixing device and method for a cell analyzer to address these issues. Summary of the Invention

[0006] (1) Technical problems solved

[0007] In response to the shortcomings of the existing technology, the present invention provides a cell analyzer mixing device and mixing method, which solves the problem that the existing blood sample automatic mixing device has a complex structure, relatively high manufacturing cost, and is not suitable for the mixing operation of ordinary venous blood samples.

[0008] (2) Technical solution

[0009] To achieve the above objectives, the present invention is implemented through the following technical solutions: A cell analyzer mixing device, comprising a device body, a main shaft rotatably provided on the device body, a fixing frame fixed in the device body, a rotating shaft rotatably provided on the fixing frame, and a transmission connection between the rotating shaft and the main shaft via a gear transmission mechanism;

[0010] A stirring rod is fixed on the rotating shaft, a stirring brush is fixed on the stirring rod, a movable frame is movably provided in the main body of the device, a plurality of clamping rings are fixed on the movable frame, test tubes are movably clamped in the clamping rings, and the movable frame is movably mounted on the inner wall of the main body of the device through a clamping assembly;

[0011] A secondary shaft is rotatably provided on the main body of the device, and the secondary shaft is connected to the main shaft via a belt transmission mechanism;

[0012] A plurality of cams are fixed on the secondary shaft.

[0013] Preferably, a motor is fixed on the device body, and the output end of the motor is fixed to the main shaft through a coupling.

[0014] Preferably, the gear transmission mechanism includes a driven gear fixed on the rotating shaft and a driving gear fixed on the main shaft, and the driven gear is meshed with the driving gear.

[0015] Preferably, the clamping ring is made of soft rubber material, and the inner diameter of the clamping ring is adapted to the outer diameter of the test tube.

[0016] Preferably, the clamping assembly includes a slide rail fixed to the inner wall of the device body and sliders fixed to both ends of the movable frame, and the sliders are slidably clamped on the slide rail.

[0017] Preferably, a stop block is fixed to the bottom end of the slide rail to prevent the slider from slipping off the slide rail.

[0018] Preferably, the belt transmission mechanism includes a driving pulley fixed on the main shaft and a driven pulley fixed on the secondary shaft, and the driving pulley and the driven pulley are connected via a belt transmission.

[0019] Preferably, a controller for controlling the electrical components of the device is fixed on the device body.

[0020] Preferably, an inspection door is hingedly mounted on the front of the device body.

[0021] A mixing method for a cell analyzer mixing device, comprising the following steps:

[0022] S1, clamping and installing multiple test tubes inside the clamping ring;

[0023] S2, starting the motor to drive the main shaft to rotate, driving the rotating shaft to rotate, driving the stirring rod to rotate, and using the stirring brush to stir the blood sample and diluent in the test tube to mix them evenly;

[0024] S3, the main shaft rotates to drive the secondary shaft to rotate, which drives the cam to rotate to repeatedly hit the bottom of the movable frame, thereby vibrating the test tube, so that the blood sample and diluent inside the test tube are mixed.

[0025] Beneficial effects

[0026] The present invention provides a cell analyzer mixing device and mixing method. Compared with the prior art, it has the following advantages:

[0027] The mixing device and mixing method for a cell analyzer first add the blood sample and diluent into the test tube before analyzing the blood sample in the test tube, then the test tube is movably clamped in the clamping ring, the motor is started to drive the main shaft to rotate, the gear transmission mechanism is used to drive the rotating shaft to rotate, thereby driving the stirring rod and the stirring brush to rotate, and the stirring brush is used to stir the blood sample and diluent in the test tube, so that the blood sample and the diluent are mixed. In addition, the main shaft rotates, and the belt transmission mechanism also synchronously drives the secondary shaft to rotate, thereby driving the cam to rotate and cooperate with the movable frame to slide and clamp in the device body to repeatedly impact the bottom of the movable frame, thereby driving the movable frame to move up and down to vibrate the test tube on the clamping ring, so that the blood sample and diluent in the test tube are mixed. Therefore, the present invention can fully and effectively mix the blood sample and the diluent, has a simple structure and low manufacturing cost, and can be suitably applied to the mixing operation of common venous blood samples. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a schematic diagram of the main structure of the present invention;

[0029] Figure 2 It is a schematic diagram of the overall structure of the present invention;

[0030] Figure 3 This is a schematic diagram of the countershaft and cam structure of the present invention;

[0031] Figure 4 Schematic diagram of the slide rail and slider structure of the present invention

[0032] Figure 5 For the present invention Figure 2 Schematic diagram of local enlarged structure

[0033] In the figure, 1. device body; 2. main shaft; 3. motor; 4. fixed frame; 5. rotating shaft; 6. driven gear; 7. driving gear; 8. stirring rod; 9. stirring brush; 10. movable frame; 11. retaining ring; 12. test tube; 13. slide rail; 14. slider; 15. secondary shaft; 16. driving pulley; 17. driven pulley; 18. belt; 19. cam; 20. controller; 21. universal wheel; 22. inspection door. DETAILED DESCRIPTION

[0034] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0035] See also Figure 1-5 , the embodiment of the present invention provides two technical solutions:

[0036] Example 1:

[0037] A cell analyzer mixing device and mixing method, comprising a device body 1, a main shaft 2 being rotatably provided on the device body 1, a fixing frame 4 being fixed inside the device body 1, a rotating shaft 5 being rotatably provided on the fixing frame 4, and a transmission connection between the rotating shaft 5 and the main shaft 2 via a gear transmission mechanism;

[0038] A stirring rod 8 is fixed to the rotating shaft 5, and a stirring brush 9 is fixed to the stirring rod 8. A movable frame 10 is movably provided in the device body 1, and a plurality of clamping rings 11 are fixed to the movable frame 10. Test tubes 12 are movably clamped in the clamping rings 11. The movable frame 10 is movably mounted on the inner wall of the device body 1 through a clamping assembly;

[0039] A secondary shaft 15 is rotatably provided on the device body 1, and the secondary shaft 15 is connected to the main shaft 2 via a belt transmission mechanism;

[0040] A plurality of cams 19 are fixed to the countershaft 15 .

[0041] Example 2:

[0042] A cell analyzer mixing device includes a device body 1, a main shaft 2 is rotatably provided on the device body 1, a fixing frame 4 is fixed in the device body 1, a rotating shaft 5 is rotatably provided on the fixing frame 4, and the rotating shaft 5 is connected to the main shaft 2 through a gear transmission mechanism;

[0043] A stirring rod 8 is fixed to the rotating shaft 5, and a stirring brush 9 is fixed to the stirring rod 8. A movable frame 10 is movably provided in the device body 1, and a plurality of clamping rings 11 are fixed to the movable frame 10. Test tubes 12 are movably clamped in the clamping rings 11. The movable frame 10 is movably mounted on the inner wall of the device body 1 through a clamping assembly;

[0044] A secondary shaft 15 is rotatably provided on the device body 1, and the secondary shaft 15 is connected to the main shaft 2 via a belt transmission mechanism;

[0045] A plurality of cams 19 are fixed to the countershaft 15 .

[0046] In this embodiment, a motor 3 is fixed on the device body 1, and the output end of the motor 3 is fixed to the main shaft 2 through a coupling. Starting the motor 3 can drive the main shaft 2 to rotate; the gear transmission mechanism includes a driven gear 6 fixed on the rotating shaft 5 and a driving gear 7 fixed on the main shaft 2. The driven gear 6 is meshed with the driving gear 7. The rotation of the main shaft 2 will drive the driving gear 7 to rotate, and the driven gear 6 is meshed with the driving gear 7 to drive the driven gear 6 to rotate, thereby driving the rotating shaft 5 to rotate; the clamping ring 11 is made of soft rubber material, and the inner diameter of the clamping ring 11 is adapted to the outer diameter of the test tube 12. The soft rubber material is soft and elastic so that the test tube 12 can be clamped inside the clamping ring 11 without causing damage to the clamping ring 11; the clamping assembly includes a slide rail 13 fixed to the inner wall of the device body 1 and sliders 14 fixed at both ends of the movable frame 10. The slider 14 is slidably clamped on the slide rail 13, and the bottom end of the slide rail 13 is fixed with a The slider 14 slides off the stop block of the slide rail 13 to ensure that the movable frame 10 can move up and down; the belt transmission mechanism includes a driving pulley 16 fixed on the main shaft 2 and a driven pulley 17 fixed on the secondary shaft 15. The driving pulley 16 and the driven pulley 17 are connected by a belt 18. When the main shaft 2 rotates, the driving pulley 16 is driven to rotate, thereby utilizing the driving pulley 16 and the driven pulley 17 to be connected by the belt 18 to drive the driven pulley 17 to rotate, thereby driving the secondary shaft 15 to rotate; a controller 20 for controlling the power components of the device is fixed on the device body 1, which is convenient for controlling the power components of the device and improving the degree of automation; an inspection door 22 is installed on the front of the device body 1 through a hinge, which is convenient for later inspection and maintenance of the interior of the device body 1; universal wheels 21 are rotatably installed at the four corners of the lower wall of the device body 1 to facilitate the transfer of the device body 1.

[0047] When the mixing device of the cell analyzer is in use, before analyzing the blood sample in the test tube 12, the blood sample and the diluent are first added into the test tube 12, and then the test tube 12 is movably clamped in the clamping ring 11, and the motor 3 is started to drive the main shaft 2 to rotate, and the gear transmission mechanism is used to drive the rotating shaft 5 to rotate, thereby driving the stirring rod 8 and the stirring brush 9 to rotate, and the stirring brush 9 is used to stir the blood sample and the diluent in the test tube 12, so that the blood sample and the diluent are mixed. In addition, the rotation of the main shaft 2 will also synchronously drive the secondary shaft 15 to rotate by the belt transmission mechanism, thereby driving the cam 19 to rotate and cooperate with the movable frame 10 to slide and clamp in the device body 1 to repeatedly impact the bottom of the movable frame 10, thereby driving the movable frame 10 to move up and down to vibrate the test tube 12 on the clamping ring 11, so that the blood sample and the diluent in the test tube 12 are mixed. Therefore, the present invention can fully and effectively mix the blood sample and the diluent, and has a simple structure and low manufacturing cost, and can be suitably applied to the mixing operation of common venous blood samples.

[0048] At the same time, the contents not described in detail in this specification belong to the existing technology well known to those skilled in the art.

[0049] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0050] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A cell analyzer mixing device, comprising a device body (1), characterized in that: A main shaft (2) is rotatably provided on the device body (1), a fixing frame (4) is fixed inside the device body (1), a rotating shaft (5) is rotatably provided on the fixing frame (4), and the rotating shaft (5) is connected to the main shaft (2) via a gear transmission mechanism; A stirring rod (8) is fixed on the rotating shaft (5), a stirring brush (9) is fixed on the stirring rod (8), a movable frame (10) is movably provided in the device body (1), a plurality of clamping rings (11) are fixed on the movable frame (10), a test tube (12) is movably clamped in the clamping ring (11), and the movable frame (10) is movably mounted on the inner wall of the device body (1) through a clamping assembly; A secondary shaft (15) is rotatably provided on the device body (1), and the secondary shaft (15) is connected to the main shaft (2) via a belt transmission mechanism; A plurality of cams (19) are fixed on the secondary shaft (15).

2. A cell analyzer mixing device according to claim 1, characterized in that: A motor (3) is fixed on the device body (1), and the output end of the motor (3) is fixed to the main shaft (2) via a coupling.

3. A cell analyzer mixing device according to claim 1, characterized in that: The gear transmission mechanism comprises a driven gear (6) fixed on a rotating shaft (5) and a driving gear (7) fixed on a main shaft (2), wherein the driven gear (6) is meshed with the driving gear (7).

4. A cell analyzer mixing device according to claim 1, characterized in that: The clamping ring (11) is made of soft rubber material, and the inner diameter of the clamping ring (11) is compatible with the outer diameter of the test tube (12).

5. A cell analyzer mixing device according to claim 1, characterized in that: The clamping assembly comprises a slide rail (13) fixed on the inner wall of the device body (1) and sliders (14) fixed on both ends of the movable frame (10), and the sliders (14) are slidably clamped on the slide rail (13).

6. A cell analyzer mixing device according to claim 5, characterized in that: A stop block is fixed to the bottom end of the slide rail (13) for preventing the slider (14) from slipping off the slide rail (13).

7. A cell analyzer mixing device according to claim 1, characterized in that: The belt transmission mechanism comprises a driving pulley (16) fixed on the main shaft (2) and a driven pulley (17) fixed on the secondary shaft (15), and the driving pulley (16) and the driven pulley (17) are connected by a belt (18).

8. A cell analyzer mixing device according to claim 1, characterized in that: A controller (20) for controlling the power components of the device is fixed on the device body (1).

9. A cell analyzer mixing device according to claim 1, characterized in that: An inspection door (22) is hingedly mounted on the front of the device body (1) via a hinge.

10. A mixing method for a cell analyzer mixing device according to any one of claims 1 to 9, characterized in that: The specific steps include: S1, clamping and installing a plurality of test tubes (12) inside the clamping ring (11); S2, starting the motor (3) to drive the main shaft (2) to rotate, driving the rotating shaft (5) to rotate, driving the stirring rod (8) to rotate, and using the stirring brush (9) to stir the blood sample and diluent in the test tube (12) to mix them evenly; S3, the main shaft (2) rotates to drive the secondary shaft (15) to rotate and drive the cam (19) to rotate to repeatedly impact the bottom of the movable frame (10) to vibrate the test tube (12), so that the blood sample and diluent inside the test tube (12) are mixed.

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