Continuous flow primidone synthesis reaction temperature accurate regulation and control system and method

Abstract

The invention relates to the technical field of medicine, and discloses a continuous flow primidone synthesis reaction temperature accurate regulation and control system and method, and the method comprises the steps: analyzing the reaction characteristics of a primidone synthesis reaction, identifying the optimal temperature interval of the primidone synthesis reaction, and configuring a continuous flow reactor of the primidone synthesis reaction; the method comprises the following steps: extracting temperature distribution characteristics of a continuous flow reactor, and arranging a multi-point temperature monitor for synthesis reaction of primidone in the continuous flow reactor; in combination with the target temperature of the continuous flow reactor and the real-time temperature of the synthetic reaction of the primidone, creating a temperature anomaly feedback node of the synthetic reaction of the primidone; analyzing a temperature fluctuation rule of the synthesis reaction of the primidone, and setting an automatic temperature adjusting mechanism of the synthesis reaction of the primidone; and in combination with a multi-point temperature monitor, an automatic temperature regulation mechanism and a temperature anomaly feedback node, performing temperature regulation and control treatment on the primidone synthesis reaction to obtain a temperature regulation and control result. According to the method, the product quality and yield of the synthesis reaction of the primidone can be improved.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a system and method for accurately controlling the temperature of a continuous-flow primidone synthesis reaction. Background Art

[0002] The continuous flow primidone synthesis reaction refers to the process of transporting the raw materials for synthesizing primidone, such as diethyl phenylethylmalonate and thiourea, at a certain flow rate and ratio to a continuous flow reactor for chemical reaction. In recent years, the incidence of mental illness has increased year by year worldwide, and more and more people have become more aware of epilepsy. The demand for effective treatment drugs from epilepsy patients and their families has increased, prompting doctors to use primidone more frequently to synthesize anti-epileptic drugs, thereby driving the growth of demand for primidone.

[0003] However, the traditional method for synthesizing primidone is mainly achieved using a batch reactor. Although this method can ensure the smooth progress of the primidone synthesis reaction, due to the low temperature control accuracy of the batch reactor, it is easy to cause fluctuations in reaction conditions, affecting product quality and yield. Summary of the Invention

[0004] The present invention provides a system and method for precise temperature control of a continuous-flow primidone synthesis reaction, the main purpose of which is to improve the product quality and yield of the primidone synthesis reaction.

[0005] To achieve the above objectives, the present invention provides a continuous flow primidone synthesis reaction temperature precision control system, comprising: a reactor configuration module, a multi-point temperature monitoring module, a temperature anomaly feedback module, an adaptive temperature adjustment module, and a temperature intelligent control module;

[0006] The reactor configuration module is used to obtain reactants for the primidone synthesis reaction, analyze the reaction characteristics of the primidone synthesis reaction based on the reactants, identify the optimal temperature range of the primidone synthesis reaction according to the reaction characteristics, and configure a continuous flow reactor for the primidone synthesis reaction;

[0007] The multi-point temperature monitoring module is used to identify the structural type of the continuous flow reactor, extract the temperature distribution characteristics of the continuous flow reactor based on the structural type, and set a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics;

[0008] The temperature anomaly feedback module is used to set the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics, collect the real-time temperature of the primidone synthesis reaction based on the multi-point temperature monitor, and create a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature;

[0009] The adaptive temperature adjustment module is used to collect historical temperature data of the primidone synthesis reaction, analyze the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data, and set the temperature automatic adjustment mechanism of the primidone synthesis reaction based on the temperature fluctuation pattern and the target temperature;

[0010] The intelligent temperature control module is used to combine the multi-point temperature monitor, the automatic temperature adjustment mechanism and the temperature abnormality feedback node to perform temperature control processing of the primidone synthesis reaction and obtain a temperature control result.

[0011] Optionally, analyzing the reaction characteristics of the primidone synthesis reaction based on the reactants includes:

[0012] Identifying the chemical structure of the reactant and analyzing the reaction pathway of the primidone synthesis reaction based on the chemical structure;

[0013] Based on the reaction pathway, extracting the thermodynamic and kinetic characteristics of the primidone synthesis reaction;

[0014] Determining the operating conditions of the primidone synthesis reaction in combination with the thermodynamic characteristics and the kinetic characteristics;

[0015] Based on the operating conditions, analyzing the catalyst properties of the primidone synthesis reaction;

[0016] The reaction characteristics of the primidone synthesis reaction are analyzed based on the reaction pathway, the thermodynamic characteristics, the kinetic characteristics, the operating conditions and the properties of the catalyst.

[0017] Optionally, identifying the optimal temperature range for the primidone synthesis reaction according to the reaction characteristics comprises:

[0018] extracting the reaction raw materials and target product of the primidone synthesis reaction according to the reaction characteristics;

[0019] Determining the entropy change parameter and enthalpy change parameter of the primidone synthesis reaction based on the reaction raw materials and the target product;

[0020] Calculating the equilibrium coefficient of the primidone synthesis reaction according to the entropy change parameter and the enthalpy change parameter;

[0021] Identifying the frequency factor and minimum barrier energy of the primidone synthesis reaction;

[0022] calculating a reaction rate constant of the primidone synthesis reaction based on the frequency factor and the minimum barrier energy;

[0023] According to the equilibrium coefficient and the reaction rate constant, setting the optimal temperature determination condition for the primidone synthesis reaction;

[0024] Based on the optimal temperature determination condition, the optimal temperature range of the primidone synthesis reaction is identified.

[0025] Optionally, extracting the temperature distribution characteristics of the continuous flow reactor based on the structure type includes:

[0026] Based on the structural type, setting temperature measurement points of the continuous flow reactor;

[0027] According to the temperature measurement points, measuring radial thermal state distribution parameters and axial thermal field distribution values of the continuous flow reactor;

[0028] Identifying hot spots and cold spots of the continuous flow reactor based on the radial thermal state distribution parameter and the axial thermal field distribution value;

[0029] constructing a temperature distribution map of the continuous flow reactor according to the hot spot area and the cold spot area;

[0030] Based on the temperature distribution graph, temperature distribution characteristics of the continuous flow reactor are extracted.

[0031] Optionally, the multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor is set according to the temperature distribution characteristics, comprising:

[0032] Determining a reaction hotspot region and a temperature stable region of the continuous flow reactor according to the temperature distribution characteristics;

[0033] Setting a monitor layout for the primidone synthesis reaction based on the reaction hotspot area and the temperature stable area;

[0034] configuring a classification monitor for the primidone synthesis reaction in the continuous flow reactor according to the monitor layout;

[0035] collecting real-time temperature data from the classification monitor, and analyzing a reaction trend of the primidone synthesis reaction based on the real-time temperature data;

[0036] constructing an adaptive control network for the primidone synthesis reaction in the continuous flow reactor according to the reaction trend;

[0037] In combination with the monitor layout, the classification monitor and the adaptive control network, a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor is set.

[0038] Optionally, setting the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics includes:

[0039] performing a zone division process on the continuous flow reactor according to the temperature distribution characteristics to obtain temperature zones;

[0040] analyzing temperature variation characteristics of the temperature zones;

[0041] Based on the optimal temperature range, identifying the required temperature corresponding to the temperature zone;

[0042] In combination with the required temperature and the temperature change characteristics, setting the zone temperature control mode of the temperature zone;

[0043] Based on the zone temperature control method, setting the zone temperature control range of the temperature zone;

[0044] The target temperature of the continuous flow reactor is set according to the zoned temperature control range.

[0045] Optionally, the step of combining the target temperature and the real-time temperature to create a temperature anomaly feedback node for the primidone synthesis reaction includes:

[0046] combining the target temperature and the real-time temperature to collect temperature deviation data of the primidone synthesis reaction;

[0047] extracting a multi-dimensional temperature deviation feature of the primidone synthesis reaction from the temperature deviation data;

[0048] performing temperature anomaly detection processing for the primidone synthesis reaction according to the multi-dimensional temperature deviation characteristics to obtain a temperature anomaly detection result;

[0049] setting a temperature anomaly level of the primidone synthesis reaction based on the temperature anomaly detection result;

[0050] creating a graded temperature anomaly feedback mechanism for the primidone synthesis reaction according to the temperature anomaly level;

[0051] The multi-dimensional temperature deviation characteristics and the graded temperature anomaly feedback mechanism are combined to create a temperature anomaly feedback node for the primidone synthesis reaction.

[0052] Optionally, analyzing the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data includes:

[0053] extracting the temperature fluctuation characteristics of the primidone synthesis reaction and its corresponding temperature fluctuation factor based on the historical temperature data;

[0054] Based on the temperature fluctuation characteristics, the temperature fluctuation causes and reaction performance of the primidone synthesis reaction were analyzed;

[0055] According to the temperature fluctuation cause, locating the initial trigger point of the temperature fluctuation factor;

[0056] Establishing a causal correspondence between the initial trigger point and the temperature fluctuation factor;

[0057] Based on the temperature fluctuation characteristics and the cause-effect correspondence, analyzing the effect of the temperature fluctuation factor on the reaction performance;

[0058] Creating a correlation relationship system between the temperature fluctuation factor and the reaction performance according to the interaction relationship;

[0059] Combining the causal correspondence and the correlation system, the temperature fluctuation law of the primidone synthesis reaction is analyzed.

[0060] Optionally, setting a temperature automatic adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation law and the target temperature includes:

[0061] extracting the reaction index of the primidone synthesis reaction under the temperature fluctuation law;

[0062] Analyzing the reaction progress of the primidone synthesis reaction according to the temperature variation rule and the reaction index;

[0063] Calculating the importance coefficient of the reaction indicator in the reaction process, and extracting the key reaction indicator of the reaction process based on the importance coefficient;

[0064] In combination with the key reaction index, the reaction progress and the target temperature, setting a multi-process temperature adjustment mode for the primidone synthesis reaction, and defining a mode switching condition for the multi-process temperature adjustment mode;

[0065] Analyzing the temperature regulation effect of the primidone synthesis reaction according to the multi-process temperature regulation mode;

[0066] Based on the temperature regulation effect, a performance feedback unit for the primidone synthesis reaction is created;

[0067] In combination with the multi-process temperature adjustment mode, the mode switching condition and the performance feedback unit, an automatic temperature adjustment mechanism for the primidone synthesis reaction is set.

[0068] The embodiment of the present invention analyzes the reaction characteristics of the primidone synthesis reaction based on the reactants, which can provide a basis for the design and configuration of reaction equipment, ensure the safety and efficiency of the reaction, and optimize the reaction conditions to improve the reaction efficiency and product quality. Furthermore, the embodiment of the present invention identifies the optimal temperature range of the primidone synthesis reaction according to the reaction characteristics, which can optimize the heat transfer design of the reactor, ensure uniform temperature distribution in the reactor, and avoid local temperature anomalies. The embodiment of the present invention configures the continuous flow reactor of the primidone synthesis reaction according to the reaction characteristics, which can ensure that the reactants are fully contacted under optimal conditions and reduce the occurrence of side reactions. Furthermore, the embodiment of the present invention sets a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics, which can timely feedback the temperature unevenness in the reaction, ensure the consistency of the reaction conditions, and improve the safety and stability of the primidone synthesis reaction. The embodiment of the present invention sets the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics, which can ensure that the reaction is carried out under the most suitable conditions. Thereby, the reaction efficiency and product yield are improved; further, the embodiment of the present invention creates a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature, which can issue an alarm or automatically trigger safety measures when the temperature exceeds the safety range, thereby effectively avoiding potential safety risks; the embodiment of the present invention sets a temperature automatic adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation law and the target temperature, which can ensure that the reaction process is always carried out within the optimal temperature range, helps to reduce side reactions and impurity generation caused by temperature fluctuations, thereby improving the purity and yield of primidone; finally, the embodiment of the present invention performs temperature control processing for the primidone synthesis reaction by combining the multi-point temperature monitor, the temperature automatic adjustment mechanism and the temperature anomaly feedback node to obtain a temperature control result, which can optimize the primidone synthesis reaction process, reduce side reactions, allow more reactants to be converted into target products, greatly improve the reaction yield, and also avoid the product from being mixed with impurities or changing the crystal form due to temperature fluctuations, ensuring the high purity and quality stability of primidone, effectively reducing quality differences between batches, and facilitating standardized production of drugs. Therefore, an embodiment of the present invention provides a system and method for precise temperature control of a continuous flow primidone synthesis reaction, which can improve the product quality and yield of the primidone synthesis reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0069] Figure 1 A functional module diagram of a continuous flow primidone synthesis reaction temperature precision control system provided by one embodiment of the present invention;

[0070] Figure 2A schematic flow chart of a method for precise temperature control of a continuous flow primidone synthesis reaction provided by one embodiment of the present invention;

[0071] The purpose, features and advantages of the present invention will be further described with reference to the accompanying drawings and in conjunction with the embodiments. DETAILED DESCRIPTION

[0072] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0073] In addition, the step sequence in the following method embodiments is only an example and not a strict limitation.

[0074] In practice, the server-side device deployed by a continuous-flow primidone synthesis reaction temperature precision control system may be composed of one or more devices. The aforementioned continuous-flow primidone synthesis reaction temperature precision control system can be implemented as: a service instance, a virtual machine, and hardware devices. For example, the continuous-flow primidone synthesis reaction temperature precision control system can be implemented as a service instance deployed on one or more devices in a cloud node. Simply put, the continuous-flow primidone synthesis reaction temperature precision control system can be understood as software deployed on a cloud node, used to provide a continuous-flow primidone synthesis reaction temperature precision control service to each client. Alternatively, the continuous-flow primidone synthesis reaction temperature precision control system can be implemented as a virtual machine deployed on one or more devices in a cloud node. Application software for managing each client is installed in the virtual machine. Alternatively, the continuous-flow primidone synthesis reaction temperature precision control system can be implemented as a server-side device composed of numerous hardware devices of the same or different types, with one or more hardware devices configured to provide a continuous-flow primidone synthesis reaction temperature precision control service to each client.

[0075] In terms of implementation, a continuous-flow primidone synthesis reaction temperature precision control system and a user terminal are mutually compatible. Specifically, the continuous-flow primidone synthesis reaction temperature precision control system is implemented as an application installed on a cloud service platform, and the user terminal is implemented as a client that establishes a communication connection with the application; alternatively, the continuous-flow primidone synthesis reaction temperature precision control system is implemented as a website, and the user terminal is implemented as a webpage; alternatively, the continuous-flow primidone synthesis reaction temperature precision control system is implemented as a cloud service platform, and the user terminal is implemented as a mini-program within an instant messaging application.

[0076] Reference Figure 1 , which is a functional module diagram of a continuous flow primidone synthesis reaction temperature precision control system provided by one embodiment of the present invention.

[0077] The continuous flow primidone synthesis reaction temperature precision control system 100 of the present invention can be set in a cloud server. In terms of implementation, it can be used as one or more service devices, or as an application installed on the cloud (for example, a server, server cluster, etc. for continuous flow primidone synthesis reaction temperature precision control), or it can also be developed as a website. According to the functions implemented, the continuous flow primidone synthesis reaction temperature precision control system 100 includes a reactor configuration module 101, a multi-point temperature monitoring module 102, a temperature anomaly feedback module 103, an adaptive temperature adjustment module 104, and a temperature intelligent control module 105.

[0078] In an embodiment of the present invention, based on the tracking of a continuous flow primidone synthesis reaction temperature precision control, each of the above modules can be independently implemented and called with other modules. The call here can be understood as a module that can connect multiple modules of another type and provide corresponding services to the multiple modules connected to it. In a continuous flow primidone synthesis reaction temperature precision control system provided by an embodiment of the present invention, there is no need to modify the program code. The scope of application of a continuous flow primidone synthesis reaction temperature precision control architecture can be adjusted by adding modules and directly calling, thereby realizing cluster-type horizontal expansion, so as to achieve the purpose of quickly and flexibly expanding a continuous flow primidone synthesis reaction temperature precision control system. In actual applications, the above modules can be set in the same device or different devices, or they can be set in a virtual device, such as a service instance in a cloud server.

[0079] The following describes the various components and specific workflow of a continuous flow primidone synthesis reaction temperature precision control system in conjunction with specific embodiments.

[0080] The reactor configuration module 101 is used to obtain reactants for the primidone synthesis reaction, analyze the reaction characteristics of the primidone synthesis reaction based on the reactants, identify the optimal temperature range of the primidone synthesis reaction according to the reaction characteristics, and configure a continuous flow reactor for the primidone synthesis reaction.

[0081] The embodiment of the present invention can provide a basis for the subsequent configuration of the reactor by obtaining the reactants of the primidone synthesis reaction. The primidone synthesis reaction refers to a chemical reaction for synthesizing primidone, including a condensation reaction and a hydrogenation reaction. The reactants refer to the specific raw materials used in the primidone synthesis reaction, including ethyl phenylacetate, thiourea, hydrogen, a catalyst, etc.

[0082] Furthermore, the embodiments of the present invention can provide a basis for the design and configuration of reaction equipment by analyzing the reaction characteristics of the primidone synthesis reaction based on the reactants, ensuring the safety and efficiency of the reaction, and at the same time optimizing the reaction conditions, improving the reaction efficiency and product quality. The reaction characteristics refer to the various unique properties and characteristics exhibited by the primidone synthesis reaction during the process, including reaction type, kinetic and thermodynamic properties, selectivity, reaction conditions, side reactions, etc.

[0083] As an embodiment of the present invention, the analysis of the reaction characteristics of the primidone synthesis reaction based on the reactants includes: identifying the chemical structure of the reactants, and analyzing the reaction path of the primidone synthesis reaction based on the chemical structure; extracting the thermodynamic characteristics and kinetic characteristics of the primidone synthesis reaction based on the reaction path; determining the operating conditions of the primidone synthesis reaction in combination with the thermodynamic characteristics and the kinetic characteristics; analyzing the catalyst properties of the primidone synthesis reaction based on the operating conditions; analyzing the reaction characteristics of the primidone synthesis reaction based on the reaction path, the thermodynamic characteristics, the kinetic characteristics, the operating conditions and the catalyst properties.

[0084] Among them, the chemical structure refers to the arrangement of atoms and the connection mode of chemical bonds in the reactant molecules, including functional groups, stereo configuration, etc.; the reaction path refers to the specific steps that the reactants go through to convert into products, including intermediates and transition states; the thermodynamic properties refer to the equilibrium state of the reactants and the properties of energy changes, including thermodynamic parameters such as the thermal effect, equilibrium coefficient and free energy change of the reaction; the kinetic properties refer to the properties of the reactants in terms of reaction rate and proceeding mode, including kinetic parameters such as reaction rate constant, reaction order and activation energy; the operating conditions refer to the optimal temperature, pressure, pH value and solvent conditions for the reaction; and the catalyst properties refer to the type, activity, selectivity and life of the catalyst.

[0085] Optionally, the chemical structure identification of the reactant can be achieved by nuclear magnetic resonance. Based on the chemical structure, the reaction path analysis of the primidone synthesis reaction can be obtained through an intermediate capture experiment, such as a quenching experiment. Based on the reaction path, the thermodynamic characteristics extraction of the primidone synthesis reaction can be achieved through calorimetric experiments and thermodynamic data calculations. Based on the reaction path, the kinetic characteristics extraction of the primidone synthesis reaction can be determined by kinetic experiments and variable temperature experiments. Based on the operating conditions, the catalyst property analysis of the primidone synthesis reaction can be obtained by X-ray photoelectron spectroscopy characterization technology.

[0086] The embodiment of the present invention can optimize the heat transfer design of the reactor by identifying the optimal temperature range of the primidone synthesis reaction based on the reaction characteristics, ensure uniform temperature distribution in the reactor, and avoid local temperature anomalies. The optimal temperature range refers to the temperature range that is most suitable for the primidone synthesis reaction. If the reaction can proceed at a faster speed within the range of 65-75°C, then this temperature range can be regarded as the optimal temperature range.

[0087] As an embodiment of the present invention, identifying the optimal temperature range of the primidone synthesis reaction based on the reaction characteristics includes: extracting the reaction raw materials and target products of the primidone synthesis reaction based on the reaction characteristics; determining the entropy change parameter and the enthalpy change parameter of the primidone synthesis reaction based on the reaction raw materials and the target product; calculating the equilibrium coefficient of the primidone synthesis reaction based on the entropy change parameter and the enthalpy change parameter; identifying the frequency factor and the minimum barrier energy of the primidone synthesis reaction; calculating the reaction rate constant of the primidone synthesis reaction based on the frequency factor and the minimum barrier energy; setting the optimal temperature judgment condition of the primidone synthesis reaction based on the equilibrium coefficient and the reaction rate constant; and identifying the optimal temperature range of the primidone synthesis reaction based on the optimal temperature judgment condition.

[0088] Among them, the reaction raw materials refer to the starting chemical substances involved in the primidone synthesis reaction, such as acetophenone, the target product refers to the final product of the primidone synthesis reaction, the entropy change parameter refers to the change in the system disorder during the primidone synthesis reaction, the enthalpy change parameter refers to the heat absorbed or released when the primidone synthesis reaction is carried out under isothermal and isobaric conditions, the equilibrium coefficient refers to the ratio of the product concentration to the reactant concentration when the reaction reaches equilibrium, the frequency factor refers to the frequency of collisions of the reacting molecules, the minimum barrier energy refers to the minimum energy required for the reaction to occur, that is, the activation energy, the reaction rate constant refers to a proportional constant used to quantitatively describe the relationship between the primidone synthesis reaction rate and the reactant concentration, and the optimal temperature judgment condition refers to the temperature condition that makes the reaction rate and equilibrium coefficient reach the optimal level.

[0089] Optionally, the entropy change parameter determination of the primidone synthesis reaction based on the reaction raw materials and the target product can be obtained by differential scanning calorimetry, the enthalpy change parameter determination of the primidone synthesis reaction based on the reaction raw materials and the target product can be achieved by isothermal calorimetry, the equilibrium coefficient calculation of the primidone synthesis reaction based on the entropy change parameter and the enthalpy change parameter can be achieved by the van't Hoff equation, and the frequency factor and minimum barrier energy identification of the primidone synthesis reaction can be determined by the Arrhenius equation.

[0090] Furthermore, the embodiment of the present invention configures a continuous flow reactor for the primidone synthesis reaction according to the reaction characteristics, thereby ensuring that the reactants are fully contacted under optimal conditions and reducing the occurrence of side reactions. The continuous flow reactor refers to a device that performs chemical reactions through a pipeline or microchannel system, such as a microchannel reactor, a tubular reactor, a continuously stirred multi-stage reactor, etc.

[0091] Optionally, according to the reaction characteristics, the continuous flow reactor configuration of the primidone synthesis reaction can be implemented using a tubular reactor.

[0092] The multi-point temperature monitoring module 102 is used to identify the structural type of the continuous flow reactor, extract the temperature distribution characteristics of the continuous flow reactor based on the structural type, and set the multi-point temperature monitor of the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics.

[0093] By identifying the structural type of the continuous flow reactor, the embodiments of the present invention can help determine key locations where temperature anomalies may occur, thereby setting temperature monitoring points in a targeted manner. The structural type refers to the specific form of the reactor in terms of physical structure, shape, internal channel layout, and components. For example, a tubular reactor is generally a tubular structure with a relatively large length-to-diameter ratio, usually with smooth channels inside, and may also have some components for enhancing mixing or heat transfer (static mixers).

[0094] Optionally, the structural type of the continuous flow reactor can be identified using the equipment manual.

[0095] Furthermore, the embodiment of the present invention extracts the temperature distribution characteristics of the continuous flow reactor based on the structural type, and can set heating or cooling devices at different positions according to the temperature distribution to ensure that the reaction is carried out at an appropriate temperature. The temperature distribution characteristics refer to the law in which the temperature inside the reactor changes with factors such as spatial position and time. For example, in a tubular reactor, due to heat transfer between the reactants and the tube wall during the flow of the tube and the release or absorption of reaction heat, a significant temperature gradient may be formed along the length of the tube, and the temperature at the inlet and outlet may be quite different.

[0096] As an embodiment of the present invention, extracting the temperature distribution characteristics of the continuous flow reactor based on the structural type includes: setting temperature measurement points of the continuous flow reactor based on the structural type; measuring radial thermal distribution parameters and axial thermal field distribution values of the continuous flow reactor according to the temperature measurement points; identifying hot spot areas and cold spot areas of the continuous flow reactor based on the radial thermal distribution parameters and the axial thermal field distribution values; constructing a temperature distribution map of the continuous flow reactor based on the hot spot areas and the cold spot areas; and extracting the temperature distribution characteristics of the continuous flow reactor based on the temperature distribution map.

[0097] Among them, the temperature measurement point refers to the position selected on the continuous flow reactor for installing a temperature measuring instrument (such as a thermocouple or a thermal resistor); the radial thermal distribution parameter refers to a data set obtained by measuring the temperature at different radial positions on the cross-section of the continuous flow reactor, which is used to describe the temperature distribution characteristics in the radial direction of the reactor; the axial thermal field distribution value refers to a sequence of temperature measurement values at different axial positions of the continuous flow reactor; the hot spot area refers to the area with the relatively highest temperature in the continuous flow reactor; the cold spot area refers to the area with the relatively lowest temperature in the continuous flow reactor; and the temperature distribution diagram refers to a diagram that graphically and intuitively displays the temperature distribution in the continuous flow reactor.

[0098] Optionally, the measurement of the radial thermal state distribution parameters and the axial thermal field distribution values of the continuous flow reactor based on the temperature measurement points can be achieved using a temperature measuring instrument, such as a thermocouple instrument. The identification of hot spot areas and cold spot areas of the continuous flow reactor based on the radial thermal state distribution parameters and the axial thermal field distribution values can be achieved through data processing software, such as Origin software. The specific steps are: using Origin software to set the temperature threshold of the continuous flow reactor to screen out possible hot spot and cold spot areas, and then determining the hot spot and cold spot areas by calculating the temperature standard deviation in the area. The construction of the temperature distribution map of the continuous flow reactor based on the hot spot area and the cold spot area can be achieved using a two-dimensional isotherm map. The extraction of the temperature distribution features of the continuous flow reactor based on the temperature distribution map can be obtained through a data mining algorithm, such as a cluster analysis algorithm.

[0099] In an embodiment of the present invention, a multi-point temperature monitor is set for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics, so that temperature unevenness in the reaction can be fed back in a timely manner, the consistency of the reaction conditions can be ensured, and the safety and stability of the primidone synthesis reaction can be improved. The multi-point temperature monitor refers to a device or system for temperature monitoring during the primidone synthesis reaction.

[0100] As an embodiment of the present invention, the method of setting up a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics comprises: determining a reaction hotspot area and a temperature stable area of the continuous flow reactor according to the temperature distribution characteristics; setting up a monitor layout for the primidone synthesis reaction based on the reaction hotspot area and the temperature stable area; configuring a classification monitor for the primidone synthesis reaction in the continuous flow reactor according to the monitor layout; collecting real-time temperature data under the classification monitor, and analyzing the reaction trend of the primidone synthesis reaction based on the real-time temperature data; constructing an adaptive control network for the primidone synthesis reaction in the continuous flow reactor according to the reaction trend; and setting up a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor in combination with the monitor layout, the classification monitor and the adaptive control network.

[0101] Among them, the reaction hot spot area refers to the area with the relatively highest temperature when the primidone synthesis reaction is carried out in a continuous flow reactor, the temperature stable area refers to the area in the continuous flow reactor where the temperature change is relatively small and relatively stable, the monitor layout refers to a scheme for rationally arranging and disposing the monitors in the reactor or related positions according to the distribution of the reaction hot spot area and the temperature stable area, the classified monitors refer to different monitors obtained by classifying the monitors used to monitor the primidone synthesis reaction according to different monitoring needs and purposes, such as arranging high-precision sensors in the hot spot area and arranging low-cost sensors in the low-temperature area, the real-time temperature data refers to the temperature data of each monitoring point in the continuous flow reactor at the current moment, which is collected and transmitted in real time by the temperature monitor during the primidone synthesis reaction, the reaction trend refers to the development direction of the primidone synthesis reaction in the future period predicted based on the collected real-time temperature data and other relevant monitoring data, and the adaptive control network refers to a network system that can automatically adjust the reaction conditions and control parameters according to the real-time status and change trend of the primidone synthesis reaction in the continuous flow reactor.

[0102] Optionally, according to the monitor layout, the classified monitor configuration of the primidone synthesis reaction in the continuous flow reactor can be realized using optical fiber sensors and resistance temperature detectors, and according to the reaction trend, the adaptive control network construction of the primidone synthesis reaction in the continuous flow reactor can be realized using an adaptive control system, such as a distributed control system.

[0103] In an optional embodiment of the present invention, based on the real-time temperature data, the reaction trend of the primidone synthesis reaction is analyzed using the following formula:

[0104]

[0105] Where C represents the reaction trend of the primidone synthesis reaction, m represents the total number of data points in the real-time temperature data, e represents the data point index of the real-time temperature data, t e Indicates the time point at which the temperature of the e-th data point is measured, f(t e ) represents the time point t e The temperature measurement value, h represents the time interval between two consecutive temperature measurements, f(t e +h) indicates the time point t e Then the temperature measurement value after time interval h.

[0106] The temperature anomaly feedback module 103 is used to set the target temperature of the continuous flow reactor based on the optimal temperature range and the temperature distribution characteristics, collect the real-time temperature of the primidone synthesis reaction based on the multi-point temperature monitor, and create a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature.

[0107] The embodiment of the present invention sets the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics, thereby ensuring that the reaction is carried out under the most suitable conditions, thereby improving the reaction efficiency and product yield. The target temperature refers to an ideal temperature value pre-set according to the optimal temperature range of the reaction. For example, if the optimal temperature range of the primidone synthesis reaction is 60°C to 70°C, the target temperature may be 65°C.

[0108] As an embodiment of the present invention, setting the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics includes: performing regional division processing of the continuous flow reactor according to the temperature distribution characteristics to obtain temperature zones; analyzing the temperature change characteristics of the temperature zones; identifying the required temperatures corresponding to the temperature zones based on the optimal temperature range; setting the zoned temperature control method of the temperature zones in combination with the required temperature and the temperature change characteristics; setting the zoned temperature control range of the temperature zones based on the zoned temperature control method; and setting the target temperature of the continuous flow reactor according to the zoned temperature control range.

[0109] Among them, the zone division process refers to the operation process of dividing the space of the continuous flow reactor into different zones based on the temperature distribution characteristics within the continuous flow reactor. The temperature zones refer to the different temperature zones obtained after the zone division process. The required temperature refers to the specific temperature value or temperature range determined for each temperature zone based on the optimal temperature range, which is suitable for the reaction or process in the zone. For example, in a continuous flow reactor with a multi-step reaction, the first step of the reaction may need to be carried out at a lower temperature. This lower temperature is the required temperature of the temperature zone where the reaction is located. The temperature variation characteristics refer to the characteristics of the temperature in different temperature zones in the continuous flow reactor as a function of time, reaction progress, and other factors, such as the temperature variation cycle and temperature fluctuation range. The zone temperature control method refers to the specific temperature control method and strategy adopted for each temperature zone. For example, for zones where the temperature is prone to rising, a temperature control method of increasing the flow rate of the cooling medium can be adopted. For zones that need to maintain a higher temperature, electric heating or steam heating can be used for temperature control. The zone temperature control range refers to the range in which the temperature of the temperature zone should be maintained during normal operation.

[0110] Optionally, the temperature change characteristic analysis of the temperature partition can be obtained through a classification algorithm, such as a support vector machine algorithm. In combination with the required temperature and the temperature change characteristics, the partition temperature control mode setting of the temperature partition can be implemented using an independent temperature control system, such as arranging independent heating / cooling units at different positions of the reactor to achieve partition temperature control. Based on the partition temperature control mode, the partition temperature control range setting of the temperature partition can be implemented by an optimization algorithm, such as a genetic algorithm.

[0111] In an optional embodiment of the present invention, based on the optimal temperature range, the required temperature corresponding to the temperature zone is identified using the following formula:

[0112]

[0113] Among them, T red,i represents the required temperature corresponding to the i-th temperature zone, Indicates temperature zone A i The corresponding average temperature, A i represents the i-th temperature partition, and p represents the temperature partition A i Temperature sampling point within, T p Indicates the temperature value at the temperature sampling point p, T min Indicates the lower limit of the optimal temperature range, T max It represents the upper limit of the optimal temperature range, and i represents the serial number of the temperature partition.

[0114] It should be noted that when When , it means that the temperature of the partition is too low, and the required temperature is set to the lower limit of the optimal temperature range. When , it means that the average temperature of the partition is within the optimal temperature range. At this time, the demand temperature should be the average temperature of the partition. , it means that the temperature of the partition is too high and the required temperature is set to the upper limit of the optimal temperature range.

[0115] In the embodiment of the present invention, the real-time temperature of the primidone synthesis reaction is collected based on the multi-point temperature monitor, which can be compared with the preset target temperature to ensure that the temperature inside the reactor is uniform and stable within the optimal temperature range. The real-time temperature refers to the actual temperature value inside the reactor measured and recorded in real time by the multi-point temperature monitor during the reaction.

[0116] Furthermore, the embodiment of the present invention creates a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature, which can issue an alarm or automatically trigger safety measures when the temperature exceeds the safety range, thereby effectively avoiding potential safety risks. The temperature anomaly feedback node refers to a system for monitoring, judging and responding to temperature anomalies during the primidone synthesis reaction.

[0117] As an embodiment of the present invention, the creation of a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature includes: collecting temperature deviation data of the primidone synthesis reaction by combining the target temperature and the real-time temperature; extracting multidimensional temperature deviation characteristics of the primidone synthesis reaction from the temperature deviation data; performing temperature anomaly detection processing on the primidone synthesis reaction according to the multidimensional temperature deviation characteristics to obtain a temperature anomaly detection result; setting a temperature anomaly level of the primidone synthesis reaction based on the temperature anomaly detection result; creating a graded temperature anomaly feedback mechanism for the primidone synthesis reaction according to the temperature anomaly level; and creating a temperature anomaly feedback node for the primidone synthesis reaction by combining the multidimensional temperature deviation characteristics and the graded temperature anomaly feedback mechanism.

[0118] Among them, the temperature deviation data refers to a data set consisting of the difference between the real-time temperature and the target temperature, the multi-dimensional temperature deviation feature refers to multiple feature parameters extracted from the temperature deviation data, including the absolute value of the deviation between the real-time temperature and the target temperature, the temperature change rate, the temperature fluctuation frequency, etc., the temperature anomaly detection processing refers to the process of judging whether there is a temperature anomaly through an algorithm or model based on the multi-dimensional temperature deviation feature, the temperature anomaly detection result refers to the conclusion obtained after the anomaly detection processing, such as the temperature is too high, the temperature is too low, the temperature fluctuates greatly, etc., the temperature anomaly level refers to the severity grade obtained after classifying the severity of the anomaly according to the anomaly detection result, and the graded temperature anomaly feedback mechanism refers to different feedback measures set according to the anomaly level, such as issuing a warning and recording data in case of minor anomalies, but not interrupting the response, automatically adjusting the heating / cooling power in case of moderate anomalies, and trying to restore to normal, and emergency stopping the response and starting the safety protocol in case of serious anomalies.

[0119] Optionally, the extraction of multidimensional temperature deviation characteristics of the primidone synthesis reaction from the temperature deviation data can be achieved using principal component analysis. Based on the multidimensional temperature deviation characteristics, the temperature anomaly detection processing of the primidone synthesis reaction can be obtained through a clustering algorithm, such as a K-means clustering algorithm. Based on the temperature anomaly detection result, the temperature anomaly level setting of the primidone synthesis reaction can be set using a graded threshold setting, such as setting different levels of thresholds according to the size and change rate of the temperature deviation. Based on the temperature anomaly level, the creation of a graded temperature anomaly feedback mechanism for the primidone synthesis reaction can be obtained by combining a PID controller and model predictive control.

[0120] The adaptive temperature adjustment module 104 is used to collect historical temperature data of the primidone synthesis reaction, analyze the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data, and set the temperature automatic adjustment mechanism of the primidone synthesis reaction based on the temperature fluctuation pattern and the target temperature.

[0121] The embodiment of the present invention can identify the pattern and regularity of temperature fluctuation in the primidone synthesis reaction by collecting historical temperature data of the primidone synthesis reaction, wherein the historical temperature data refers to temperature information collected and recorded during the past reaction process.

[0122] Optionally, the historical temperature data of the primidone synthesis reaction can be collected using a data acquisition system, such as a PLC system.

[0123] Furthermore, the embodiments of the present invention can help optimize the temperature control strategy of the primidone synthesis reaction by analyzing the temperature fluctuation pattern of the primidone synthesis reaction based on the historical temperature data. The temperature fluctuation pattern refers to the characteristics and patterns of temperature changes over time. For example, the temperature may increase once every 10 minutes and then decrease once.

[0124] As an embodiment of the present invention, the analysis of the temperature fluctuation law of the primidone synthesis reaction based on the historical temperature data includes: extracting the temperature fluctuation characteristics of the primidone synthesis reaction and its corresponding temperature fluctuation factor based on the historical temperature data; analyzing the temperature fluctuation cause and reaction performance of the primidone synthesis reaction based on the temperature fluctuation characteristics; locating the initial trigger point of the temperature fluctuation factor based on the temperature fluctuation cause; constructing a causal correspondence between the initial trigger point and the temperature fluctuation factor; based on the temperature fluctuation characteristics and the causal correspondence, analyzing the effect of the temperature fluctuation factor on the reaction performance; creating a correlation relationship system between the temperature fluctuation factor and the reaction performance based on the effect relationship; and analyzing the temperature fluctuation law of the primidone synthesis reaction in combination with the causal correspondence and the correlation relationship system.

[0125] Among them, the temperature fluctuation characteristics refer to the characteristics of the temperature change over time during the primidone synthesis reaction, such as the amplitude, frequency, periodicity, etc. of the temperature change; the temperature fluctuation factors refer to the various factors that cause the temperature fluctuation of the primidone synthesis reaction, including the concentration, purity, addition rate and order of the reactants; the temperature fluctuation causes refer to the specific reasons that cause the temperature fluctuations, such as excessive reactant concentration, which may lead to increased reaction exotherm and thus increase the temperature; the reaction performance refers to the conversion rate, selectivity, yield, reaction rate, and product purity of the primidone synthesis reaction; the initial trigger point refers to the source of the temperature fluctuation when the temperature fluctuation factor begins to change, for example, when the temperature begins to be added to the reactant at a specific speed. When a certain reactant is added to the system, the temperature begins to change. The time point of this addition is a possible initial trigger point. The causal correspondence refers to a clear causal relationship between the initial trigger point and the temperature fluctuation factor. For example, the stirring speed is accelerated at a certain moment (initial trigger point), resulting in more complete mixing of the reactants (change in the temperature fluctuation factor), which in turn accelerates the reaction rate and increases the temperature (temperature fluctuation). The action relationship refers to the specific impact of the temperature fluctuation factor on the reaction performance. For example, an increase in temperature may lead to an increase in side reactions, thereby reducing the selectivity and purity of the product. The correlation relationship system refers to the systematic integration and summary of various action relationships between temperature fluctuation factors and reaction performance to form a comprehensive and interconnected relationship network.

[0126] Optionally, the analysis of the cause of the temperature fluctuation of the primidone synthesis reaction based on the temperature fluctuation characteristics can be achieved using the Granger causality test analysis method, the analysis of the reaction performance of the primidone synthesis reaction based on the temperature fluctuation characteristics can be obtained through a correlation analysis model, the construction of the causal correspondence between the initial trigger point and the temperature fluctuation factor can be achieved using a causal relationship model, such as a potential result framework model, the analysis of the effect of the temperature fluctuation factor on the reaction performance based on the temperature fluctuation characteristics and the causal correspondence can be obtained through a correlation coefficient method, and the creation of a correlation relationship system between the temperature fluctuation factor and the reaction performance based on the effect relationship can be achieved using a multiple linear regression model.

[0127] The embodiment of the present invention sets a temperature automatic adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation law and the target temperature, thereby ensuring that the reaction process is always carried out within the optimal temperature range, helping to reduce side reactions and impurity generation caused by temperature fluctuations, thereby improving the purity and yield of primidone. The temperature automatic adjustment mechanism refers to a control system that can automatically adjust the temperature in the reactor according to the preset target temperature and real-time monitored temperature data.

[0128] As an embodiment of the present invention, the temperature automatic adjustment mechanism of the primidone synthesis reaction is set based on the temperature fluctuation law and the target temperature, including: extracting the reaction index of the primidone synthesis reaction under the temperature fluctuation law; analyzing the reaction progress of the primidone synthesis reaction according to the temperature change law and the reaction index; calculating the importance coefficient of the reaction index in the reaction progress, and extracting the key reaction index of the reaction progress based on the importance coefficient; setting a multi-process temperature adjustment mode of the primidone synthesis reaction in combination with the key reaction index, the reaction progress and the target temperature, and defining the mode switching condition of the multi-process temperature adjustment mode; analyzing the temperature adjustment effect of the primidone synthesis reaction according to the multi-process temperature adjustment mode; creating a performance feedback unit of the primidone synthesis reaction based on the temperature adjustment effect; and setting the temperature automatic adjustment mechanism of the primidone synthesis reaction in combination with the multi-process temperature adjustment mode, the mode switching condition and the performance feedback unit.

[0129] Among them, the reaction index refers to a parameter used to measure the performance and progress of the primidone synthesis reaction, such as product purity, reaction rate, reaction selectivity, etc. The reaction process refers to the dynamic change process of the reaction from the beginning to the end. The importance coefficient refers to the relative importance of each reaction index in the reaction process. The key reaction index refers to the index that has the greatest impact on the reaction performance in the reaction process, such as reaction rate. The multi-process temperature adjustment mode refers to a variety of temperature adjustment strategies set according to the reaction process, key reaction index and target temperature. For example, at the beginning of the reaction, the target temperature is set to 65°C to accelerate the reaction rate. At the end of the reaction, the target temperature is adjusted to 63°C to improve product purity. The mode switching condition refers to the condition for automatically switching the multi-process temperature adjustment mode according to the changes in the reaction process and key reaction index, such as switching the mode when the conversion rate reaches a certain value. The temperature adjustment effect refers to the actual impact of the temperature automatic adjustment mechanism on the reaction performance. For example, when the temperature is reduced to 60°C at the end of the reaction, the product purity is increased to 95% and the impurity content is significantly reduced. The performance feedback unit refers to a system for collecting and analyzing the temperature adjustment effect.

[0130] Optionally, according to the temperature change law and the reaction index, the reaction process analysis of the primidone synthesis reaction can be determined by the change of the reaction index, the calculation of the importance coefficient of the reaction index in the reaction process can be achieved using a weight distribution formula, and the mode switching condition definition of the multi-process temperature adjustment mode in combination with the key reaction index, the reaction process and the target temperature can be achieved through a rule engine, and according to the multi-process temperature adjustment mode, the temperature adjustment effect analysis of the primidone synthesis reaction can be obtained using a numerical simulation method, such as a CFD simulation method, and based on the temperature adjustment effect, the performance feedback unit creation of the primidone synthesis reaction can be obtained through a MATLAB data analysis platform.

[0131] The temperature intelligent control module 105 is used to combine the multi-point temperature monitor, the temperature automatic adjustment mechanism and the temperature abnormality feedback node to perform temperature control processing of the primidone synthesis reaction and obtain a temperature control result.

[0132] The embodiment of the present invention combines the multi-point temperature monitor, the automatic temperature adjustment mechanism and the temperature anomaly feedback node to perform temperature control processing of the primidone synthesis reaction to obtain a temperature control result, which can optimize the primidone synthesis reaction process, reduce side reactions, and allow more reactants to be converted into target products, greatly improving the reaction yield. At the same time, it can also avoid the product from being mixed with impurities or changing the crystal form due to temperature fluctuations, ensuring the high purity and quality stability of primidone, effectively reducing quality differences between batches, and facilitating standardized production of drugs. The temperature control processing refers to a series of operations taken during the primidone synthesis reaction process to make the reaction temperature reach and maintain an ideal state. The temperature control result refers to the final state or effect obtained after the temperature control processing, such as the purity of the product may be increased from the original 90% to more than 95%, and the yield may be increased from 60% to 70%.

[0133] The embodiment of the present invention analyzes the reaction characteristics of the primidone synthesis reaction based on the reactants, which can provide a basis for the design and configuration of reaction equipment, ensure the safety and efficiency of the reaction, and optimize the reaction conditions to improve the reaction efficiency and product quality. Furthermore, the embodiment of the present invention identifies the optimal temperature range of the primidone synthesis reaction according to the reaction characteristics, which can optimize the heat transfer design of the reactor, ensure uniform temperature distribution in the reactor, and avoid local temperature anomalies. The embodiment of the present invention configures the continuous flow reactor of the primidone synthesis reaction according to the reaction characteristics, which can ensure that the reactants are fully contacted under optimal conditions and reduce the occurrence of side reactions. Furthermore, the embodiment of the present invention sets a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics, which can timely feedback the temperature unevenness in the reaction, ensure the consistency of the reaction conditions, and improve the safety and stability of the primidone synthesis reaction. The embodiment of the present invention sets the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics, which can ensure that the reaction is carried out under the most suitable conditions. Thereby, the reaction efficiency and product yield are improved; further, the embodiment of the present invention creates a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature, which can issue an alarm or automatically trigger safety measures when the temperature exceeds the safety range, thereby effectively avoiding potential safety risks; the embodiment of the present invention sets a temperature automatic adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation law and the target temperature, which can ensure that the reaction process is always carried out within the optimal temperature range, helps to reduce side reactions and impurity generation caused by temperature fluctuations, thereby improving the purity and yield of primidone; finally, the embodiment of the present invention performs temperature control processing for the primidone synthesis reaction by combining the multi-point temperature monitor, the temperature automatic adjustment mechanism and the temperature anomaly feedback node to obtain a temperature control result, which can optimize the primidone synthesis reaction process, reduce side reactions, allow more reactants to be converted into target products, greatly improve the reaction yield, and also avoid the product from being mixed with impurities or changing the crystal form due to temperature fluctuations, ensuring the high purity and quality stability of primidone, effectively reducing quality differences between batches, and facilitating standardized production of drugs. Therefore, an embodiment of the present invention provides a system and method for precise temperature control of a continuous flow primidone synthesis reaction, which can improve the product quality and yield of the primidone synthesis reaction.

[0134] like Figure 2 FIG. 1 is a flow chart of a method for precisely controlling the temperature of a continuous flow primidone synthesis reaction provided by one embodiment of the present invention. In this embodiment, the method for precisely controlling the temperature of a continuous flow primidone synthesis reaction comprises:

[0135] Obtaining reactants for a primidone synthesis reaction, analyzing reaction characteristics of the primidone synthesis reaction based on the reactants, identifying an optimal temperature range for the primidone synthesis reaction according to the reaction characteristics, and configuring a continuous flow reactor for the primidone synthesis reaction;

[0136] Identifying a structural type of the continuous flow reactor, extracting temperature distribution characteristics of the continuous flow reactor based on the structural type, and setting a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics;

[0137] According to the optimal temperature range and the temperature distribution characteristics, the target temperature of the continuous flow reactor is set, the real-time temperature of the primidone synthesis reaction is collected based on the multi-point temperature monitor, and the temperature anomaly feedback node of the primidone synthesis reaction is created by combining the target temperature and the real-time temperature;

[0138] collecting historical temperature data of the primidone synthesis reaction, analyzing the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data, and setting an automatic temperature adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation pattern and the target temperature;

[0139] In combination with the multi-point temperature monitor, the temperature automatic adjustment mechanism and the temperature abnormality feedback node, the temperature control process of the primidone synthesis reaction is performed to obtain a temperature control result.

[0140] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not limiting. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A continuous flow primidone synthesis reaction temperature precision control system, characterized in that: The continuous flow primidone synthesis reaction temperature precision control system comprises: a reactor configuration module, a multi-point temperature monitoring module, a temperature abnormality feedback module, an adaptive temperature adjustment module and a temperature intelligent control module; The reactor configuration module is used to obtain reactants for the primidone synthesis reaction, analyze the reaction characteristics of the primidone synthesis reaction based on the reactants, identify the optimal temperature range of the primidone synthesis reaction according to the reaction characteristics, and configure a continuous flow reactor for the primidone synthesis reaction; The multi-point temperature monitoring module is used to identify the structural type of the continuous flow reactor, extract the temperature distribution characteristics of the continuous flow reactor based on the structural type, and set a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics; The temperature anomaly feedback module is used to set the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics, collect the real-time temperature of the primidone synthesis reaction based on the multi-point temperature monitor, and create a temperature anomaly feedback node for the primidone synthesis reaction by combining the target temperature and the real-time temperature; The adaptive temperature adjustment module is used to collect historical temperature data of the primidone synthesis reaction, analyze the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data, and set the temperature automatic adjustment mechanism of the primidone synthesis reaction based on the temperature fluctuation pattern and the target temperature; The intelligent temperature control module is used to combine the multi-point temperature monitor, the automatic temperature adjustment mechanism and the temperature abnormality feedback node to perform temperature control processing of the primidone synthesis reaction and obtain a temperature control result.

2. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The step of analyzing the reaction characteristics of the primidone synthesis reaction based on the reactants comprises: Identifying the chemical structure of the reactant and analyzing the reaction pathway of the primidone synthesis reaction based on the chemical structure; Based on the reaction pathway, extracting the thermodynamic and kinetic characteristics of the primidone synthesis reaction; Determining the operating conditions of the primidone synthesis reaction in combination with the thermodynamic characteristics and the kinetic characteristics; Based on the operating conditions, analyzing the catalyst properties of the primidone synthesis reaction; The reaction characteristics of the primidone synthesis reaction are analyzed based on the reaction pathway, the thermodynamic characteristics, the kinetic characteristics, the operating conditions and the properties of the catalyst.

3. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The step of identifying the optimal temperature range for the primidone synthesis reaction according to the reaction characteristics comprises: extracting the reaction raw materials and target product of the primidone synthesis reaction according to the reaction characteristics; Determining the entropy change parameter and enthalpy change parameter of the primidone synthesis reaction based on the reaction raw materials and the target product; Calculating the equilibrium coefficient of the primidone synthesis reaction according to the entropy change parameter and the enthalpy change parameter; Identifying the frequency factor and minimum barrier energy of the primidone synthesis reaction; calculating a reaction rate constant of the primidone synthesis reaction based on the frequency factor and the minimum barrier energy; According to the equilibrium coefficient and the reaction rate constant, setting the optimal temperature determination condition for the primidone synthesis reaction; Based on the optimal temperature determination condition, the optimal temperature range of the primidone synthesis reaction is identified.

4. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The extracting of the temperature distribution characteristics of the continuous flow reactor based on the structure type includes: Based on the structural type, setting temperature measurement points of the continuous flow reactor; According to the temperature measurement points, measuring radial thermal state distribution parameters and axial thermal field distribution values of the continuous flow reactor; Identifying hot spots and cold spots of the continuous flow reactor based on the radial thermal state distribution parameter and the axial thermal field distribution value; constructing a temperature distribution map of the continuous flow reactor according to the hot spot area and the cold spot area; Based on the temperature distribution graph, temperature distribution characteristics of the continuous flow reactor are extracted.

5. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The method of setting a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics comprises: Determining a reaction hotspot region and a temperature stable region of the continuous flow reactor according to the temperature distribution characteristics; Setting a monitor layout for the primidone synthesis reaction based on the reaction hotspot area and the temperature stable area; configuring a classification monitor for the primidone synthesis reaction in the continuous flow reactor according to the monitor layout; collecting real-time temperature data from the classification monitor, and analyzing a reaction trend of the primidone synthesis reaction based on the real-time temperature data; constructing an adaptive control network for the primidone synthesis reaction in the continuous flow reactor according to the reaction trend; In combination with the monitor layout, the classification monitor and the adaptive control network, a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor is set.

6. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The step of setting the target temperature of the continuous flow reactor according to the optimal temperature range and the temperature distribution characteristics comprises: According to the temperature distribution characteristics, performing a region division process on the continuous flow reactor to obtain temperature zones; analyzing temperature variation characteristics of the temperature zones; Based on the optimal temperature range, identifying the required temperature corresponding to the temperature zone; In combination with the required temperature and the temperature change characteristics, setting the zone temperature control mode of the temperature zone; Based on the zone temperature control method, setting the zone temperature control range of the temperature zone; The target temperature of the continuous flow reactor is set according to the zoned temperature control range.

7. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The step of combining the target temperature and the real-time temperature to create a temperature anomaly feedback node for the primidone synthesis reaction includes: combining the target temperature and the real-time temperature to collect temperature deviation data of the primidone synthesis reaction; extracting a multi-dimensional temperature deviation feature of the primidone synthesis reaction from the temperature deviation data; performing temperature anomaly detection processing for the primidone synthesis reaction according to the multi-dimensional temperature deviation characteristics to obtain a temperature anomaly detection result; setting a temperature anomaly level of the primidone synthesis reaction based on the temperature anomaly detection result; creating a graded temperature anomaly feedback mechanism for the primidone synthesis reaction according to the temperature anomaly level; The multi-dimensional temperature deviation characteristics and the graded temperature anomaly feedback mechanism are combined to create a temperature anomaly feedback node for the primidone synthesis reaction.

8. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The step of analyzing the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data comprises: extracting the temperature fluctuation characteristics of the primidone synthesis reaction and its corresponding temperature fluctuation factor based on the historical temperature data; Based on the temperature fluctuation characteristics, the temperature fluctuation causes and reaction performance of the primidone synthesis reaction were analyzed; According to the temperature fluctuation cause, locating the initial trigger point of the temperature fluctuation factor; Establishing a causal correspondence between the initial trigger point and the temperature fluctuation factor; Based on the temperature fluctuation characteristics and the cause-effect correspondence, analyzing the effect of the temperature fluctuation factor on the reaction performance; Creating a correlation relationship system between the temperature fluctuation factor and the reaction performance according to the interaction relationship; In combination with the causal correspondence and the correlation system, the temperature fluctuation law of the primidone synthesis reaction is analyzed.

9. A continuous flow primidone synthesis reaction temperature precision control system according to claim 1, characterized in that: The automatic temperature adjustment mechanism for the primidone synthesis reaction is set based on the temperature fluctuation law and the target temperature, comprising: extracting the reaction index of the primidone synthesis reaction under the temperature fluctuation law; Analyzing the reaction progress of the primidone synthesis reaction according to the temperature variation rule and the reaction index; Calculating the importance coefficient of the reaction indicator in the reaction process, and extracting the key reaction indicator of the reaction process based on the importance coefficient; In combination with the key reaction index, the reaction progress and the target temperature, setting a multi-process temperature adjustment mode for the primidone synthesis reaction, and defining a mode switching condition for the multi-process temperature adjustment mode; Analyzing the temperature regulation effect of the primidone synthesis reaction according to the multi-process temperature regulation mode; Based on the temperature regulation effect, a performance feedback unit for the primidone synthesis reaction is created; In combination with the multi-process temperature adjustment mode, the mode switching condition and the performance feedback unit, an automatic temperature adjustment mechanism for the primidone synthesis reaction is set.

10. A method for precise temperature control of a continuous flow primidone synthesis reaction, characterized in that: The method comprises: Obtaining reactants for a primidone synthesis reaction, analyzing reaction characteristics of the primidone synthesis reaction based on the reactants, identifying an optimal temperature range for the primidone synthesis reaction according to the reaction characteristics, and configuring a continuous flow reactor for the primidone synthesis reaction; Identifying a structural type of the continuous flow reactor, extracting temperature distribution characteristics of the continuous flow reactor based on the structural type, and setting a multi-point temperature monitor for the primidone synthesis reaction in the continuous flow reactor according to the temperature distribution characteristics; According to the optimal temperature range and the temperature distribution characteristics, the target temperature of the continuous flow reactor is set, the real-time temperature of the primidone synthesis reaction is collected based on the multi-point temperature monitor, and the temperature anomaly feedback node of the primidone synthesis reaction is created by combining the target temperature and the real-time temperature; collecting historical temperature data of the primidone synthesis reaction, analyzing the temperature fluctuation pattern of the primidone synthesis reaction according to the historical temperature data, and setting an automatic temperature adjustment mechanism for the primidone synthesis reaction based on the temperature fluctuation pattern and the target temperature; In combination with the multi-point temperature monitor, the temperature automatic adjustment mechanism and the temperature abnormality feedback node, the temperature control process of the primidone synthesis reaction is performed to obtain a temperature control result.

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