Traditional Chinese medicine for improving and treating type 2 diabetes and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine for improving and treating type 2 diabetes mellitus and a preparation method thereof. The traditional Chinese medicine is prepared from radix rehmanniae recen, radix astragali, rhizoma atractylodis macrocephalae, poria with hostwood, radix salviae miltiorrhizae, rhizoma chuanxiong, peach kernels, flos carthami, ginseng, radix aconiti lateralis praeparata, fructus corni, rhizoma dioscoreae, cortex magnoliae officinalis, fructus aurantii immaturus, rhizoma zingiberis and radix glycyrrhizae preparata. All the medicines act together to achieve the effects of clearing heat, relieving restlessness, promoting salivation, tonifying qi, smoothing triple jiao, coordinating five internal organs and treating the diabetes mellitus type 2 effectively.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine for improving the treatment of type 2 diabetes and a preparation method thereof. Background Art

[0002] Diabetes mellitus is a common metabolic disease characterized by persistent hyperglycemia. Based on insulin levels, it is clinically categorized into type 1 and type 2, with type 2 being the most common. Currently, oral hypoglycemic drugs commonly used in clinical practice can be broadly divided into three categories: insulin secretagogues such as sulfonylureas, insulin sensitizers such as thiazolidinediones, and α-glucosidase inhibitors such as acarbose. However, each has its limitations and adverse reactions. Numerous studies have demonstrated the unique advantages of Traditional Chinese Medicine (TCM) in treating diabetes. Traditional Chinese medicine research has found that type 2 diabetes can be classified as a form of diabetes mellitus. The more representative prescriptions for treating diabetes mellitus in traditional Chinese medicine include: "Yuquan Pills" from Ye Tianshi of the Qing Dynasty, the prescription of the same name from Shen Jinao of the Qing Dynasty, and "Yuye Decoction" proposed by Zhang Xichun, who was born in the Qing Dynasty and died in the Republic of China. These prescriptions are composed of Pueraria root, Radix Trichosanthis, Radix Ophiopogonis, Rehmannia root, Schisandra chinensis, Licorice, and glutinous rice (Ye Tianshi's prescription); or composed of Pueraria root, Radix Ophiopogonis, Ginseng, Poria, Ophiopogon japonicus, Prunus mume, Licorice, and Astragalus (Shen Jinao's prescription); or composed of raw yam, raw Astragalus membranaceus, Rhizoma Anemarrhenae, raw chicken gizzard lining, Pueraria root, Schisandra chinensis, and Radix Trichosanthis (Zhang Xichun's prescription). However, while the above three prescriptions have some efficacy, they are limited to nourishing yin and promoting fluid production, relieving coughs and restlessness, and invigorating qi and neutralizing qi. They fail to consider that after years of illness, many patients with diabetes often experience deficiency in the five internal organs, failing to regulate all of them. For example, Ye Tianshi's prescription neglects to regulate the heart, liver, and spleen; Shen Jin'ao's prescription lacks regulation of the liver, kidneys, and even the lungs; and Zhang Xichun's prescription also fails to address the heart, liver, and kidneys. The Yellow Emperor's Classic of Internal Medicine states, "If one organ is damaged, a hundred diseases will arise; if the five organs are damaged, a hundred forms will perish." This means that chronic diseases, systemic disorders, and functional disorders are all caused by the decline of the five internal organs and the dysfunction of human function. If the five internal organs are weakened, the five meridians are blocked, qi and blood flow are blocked, and the body cannot function properly. Summary of the Invention

[0003] Based on the above background, the present invention provides a traditional Chinese medicine for improving the treatment of type 2 diabetes and its preparation method. The traditional Chinese medicine is based on the basic principle of "coordinating the five internal organs and comprehensively treating them", and uses a rational combination of ingredients to more effectively treat type 2 diabetes.

[0004] The technical solution provided by the present invention is:

[0005] A traditional Chinese medicine for improving the treatment of type 2 diabetes, which is prepared from the following raw materials by weight:

[0006] 30-60 parts of raw Rehmannia root, 30-60 parts of Astragalus root, 15-45 parts of Atractylodes macrocephala, 15-45 parts of Poria root, 15-45 parts of Salvia miltiorrhiza, 15-45 parts of Chuanxiong, 12-36 parts of peach kernel, 12-36 parts of safflower, 12-36 parts of ginseng, 13-36 parts of roasted aconite root, 9-27 parts of Cornus officinalis, 9-27 parts of Chinese yam, 9-27 parts of Magnolia officinalis, 9-27 parts of Citrus aurantium, 6-18 parts of dried ginger, and 6-18 parts of roasted liquorice.

[0007] Preferably, it is made from the following raw materials by weight:

[0008] 45 parts of raw rehmannia root, 35 parts of astragalus root, 30 parts of atractylodes macrocephala, 20 parts of poria root, 30 parts of salvia miltiorrhiza, 25 parts of ligusticum chuanxiong, 20 parts of peach kernel, 30 parts of safflower, 25 parts of ginseng, 20 parts of processed aconite root, 20 parts of cornus officinalis, 25 parts of yam, 20 parts of magnolia bark, 20 parts of immature bitter orange, 15 parts of dried ginger, 10 parts of roasted liquorice root.

[0009] Preferably, it is made from the following raw materials by weight:

[0010] 50 parts of raw rehmannia root, 30 parts of astragalus root, 30 parts of white atractylodes, 30 parts of poria, 25 parts of salvia miltiorrhiza, 35 parts of chuanxiong, 18 parts of peach kernel, 35 parts of safflower, 30 parts of ginseng, 30 parts of roasted aconite root, 25 parts of cornus officinalis, 20 parts of yam, 30 parts of magnolia bark, 25 parts of immature bitter orange, 15 parts of dried ginger, 15 parts of roasted liquorice root.

[0011] Furthermore, the traditional Chinese medicine is added with medically acceptable adjuvants to prepare an oral preparation.

[0012] Preferably, the oral dosage form is a water pill, powder, tablet or capsule.

[0013] Based on the same inventive concept, the present invention also provides a method for preparing a water pill for improving the treatment of type 2 diabetes. The water pill is prepared from the aforementioned traditional Chinese medicine for improving the treatment of type 2 diabetes as a raw material, and the preparation method comprises the following steps:

[0014] (1) Take the raw drug according to the amount, sterilize and dry it, grind it separately and then sieve it;

[0015] (2) Mixing the crushed raw materials and stirring them evenly;

[0016] (3) Sterilize and dry Pueraria root, crush it, add water, heat it for a period of time, and make it fully gelatinized into a slurry. After filtering, use the filtrate as the excipient;

[0017] (4) Mixing the medicine: Add the powder mixed evenly in step (2) to the excipient in step (3), and add water, mix and stir thoroughly to form a soft material, divide the soft material into uniform small pieces, let it cool, and then prepare pills;

[0018] (5) forming pellets from the soft material and treating the pellet surfaces to make them round and smooth;

[0019] (6) Dry and polish the pellets.

[0020] Furthermore, the dosage ratio of the drug powder to the excipient in step (4) is 1:(0.25-0.30).

[0021] Furthermore, in step (4), the ratio of excipient to water is 1:2.

[0022] Based on the same inventive concept, the present invention also provides a method for preparing a powder for improving the treatment of type 2 diabetes, which is prepared from the aforementioned traditional Chinese medicine for improving the treatment of type 2 diabetes as a raw material, and the preparation method comprises the following steps:

[0023] (1) Take the raw drug according to the amount, sterilize and dry it, grind it separately and then sieve it;

[0024] (2) Mix the crushed raw materials, stir evenly, and then package them.

[0025] Based on the same inventive concept, the present invention also applies the above-mentioned traditional Chinese medicine for improving the treatment of type 2 diabetes to the preparation of hypoglycemic preparations.

[0026] Based on the same inventive concept, the present invention also applies the above-mentioned traditional Chinese medicine for improving the treatment of type 2 diabetes to the preparation of a preparation for improving the treatment of type 2 diabetes accompanied by hypertension or hyperlipidemia.

[0027] The pharmacology of the raw materials of the present invention is shown below:

[0028] Raw Rehmannia tastes sweet and bitter, and is cold in nature. It enters the heart, liver, and kidney meridians. The bitterness is stronger than the sweetness, and the bitter and cold are clearing and purging. The juice is sweet and moist, and it is good at clearing heat and cooling blood. It is often used for excessive heat that damages body fluids and blood heat and bleeding; it clears heat and cools blood, nourishes yin and produces body fluids.

[0029] Astragalus is sweet and slightly warm in nature, entering the spleen and lung meridians. Its sweet and warm properties are tonifying and ascending, while its sweet and mild properties promote urination and dispersing. It is effective in tonifying the middle qi and raising the clear yang, as well as tonifying the lung qi, benefiting the stomach and strengthening the exterior. It treats lung qi deficiency, sinking of the middle qi, qi failure to retain blood, spontaneous sweating and night sweats. It can also dissipate toxins from sores, promote diuresis and reduce swelling. It treats sores and carbuncles that persist or persist due to qi and blood deficiency, as well as edema and urinary problems caused by qi deficiency. It also tonifies qi, generates blood, retains blood, promotes fluid production, and promotes urination. It treats sallow complexion caused by blood deficiency, metrorrhagia and bloody stools caused by qi failure to retain blood, and polydipsia caused by both qi and fluid deficiency.

[0030] Atractylodes macrocephala tastes bitter and sweet, is warm in nature, and enters the spleen and stomach meridians. Atractylodes macrocephala is sweet, nourishing, penetrating and promoting, bitter, warm and dry, and enters the spleen and stomach meridians. It is mainly used to warm and nourish and strengthen the body, and can also eliminate dampness. It is good at replenishing qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. It can treat spleen and stomach qi deficiency, spleen deficiency edema, phlegm and fluid retention, spontaneous sweating due to superficial deficiency, and fetal movement disorder.

[0031] Poria has a sweet, bland, and neutral flavor, and enters the Heart, Lung, Spleen, and Kidney meridians. It has a calming and soothing effect on the mind and is suitable for treating restlessness, palpitations, forgetfulness, and insomnia.

[0032] Salvia miltiorrhiza is bitter and slightly cold in nature, entering the Heart and Liver meridians. Its bitterness dissipates, while its slightly coldness clears, and it enters the Heart and Liver meridians. It not only invigorates blood circulation, removes stasis, and relieves pain, but also refreshes and cools the blood, alleviating restlessness and eliminating carbuncles. It primarily treats blood stasis, blood heat, and heat-induced disturbances of the mind, as well as sores, carbuncles, swelling, and pain caused by heat-induced toxicity. It cools blood, invigorates blood circulation, removes stasis, and promotes regeneration.

[0033] Chuanxiong is pungent and warm in nature, entering the Liver, Gallbladder, and Pericardium meridians. Its pungent and aromatic properties dissipate heat and promote circulation, entering the Liver, Gallbladder, and Pericardium meridians. It ascends to the head and descends to the blood sea, promoting blood circulation and qi internally while dispersing wind and cold externally. It has a strong blood-activating effect, treating pain caused by blood stasis and qi stagnation, and is particularly suitable for those with combined cold. It invigorates blood circulation, promotes qi circulation, dispels wind, and relieves pain, making it a "blood-tonifying qi medicine." It is particularly effective for treating various headaches, particularly those caused by wind-cold and blood stasis, but is also suitable for those with wind-heat, rheumatism, and blood deficiency.

[0034] Peach kernel tastes bitter and sweet, is neutral in nature, and enters the heart, liver, and large intestine meridians. It can promote blood circulation, remove blood stasis, moisten the intestines and promote bowel movements, and relieve cough and asthma.

[0035] Safflower is pungent in taste and warm in nature. It enters the heart and liver meridians. It is pungent, dispersing, warming and unblocking. It is good at promoting blood circulation, removing blood stasis, promoting menstruation, reducing swelling and relieving pain. It has strong medicinal properties and can be used to treat various blood diseases. It is most suitable for those with cold syndrome.

[0036] Ginseng is sweet, slightly bitter, and mildly warm in nature. It enters the spleen, lung, heart, and kidney meridians. Its mildly warming, slightly bitter, and non-disinfecting properties make it a powerful herb for replenishing qi and strengthening the body. It is effective in tonifying vital energy and treating qi deficiency and premature ejaculation; it also tonifies lung qi and treats symptoms of spleen and lung qi deficiency. It also replenishes qi, promotes fluid production, calms the mind, and improves intelligence. It can treat thirst caused by fluid loss, diabetes, restlessness, palpitations, and forgetfulness.

[0037] Processed Aconite Seed Extract is pungent and sweet in flavor, highly hot in nature, and enters the Heart, Kidney, and Spleen meridians. Its pungent, hot, and purely Yang properties are potent and toxic. It supports Heart Yang, warms Spleen Yang, and strengthens Kidney Yang. It is a key herb for replenishing fire and supporting Yang, restoring Yang, and rescuing adverse symptoms. It is often used to treat Yang deficiency and Yang deficiency. Its pungent, hot, and dispersing properties make it a potent herb for dispersing Yin and cold, eliminating rheumatism, and relieving pain. It is often used to treat pain caused by cold and dampness. It restores Yang, rescues adverse symptoms, replenishes fire and supports Yang, dispels cold, and relieves pain.

[0038] Cornus officinalis is sour and astringent in flavor, with a slightly warm nature. It enters the liver and kidney meridians. Its sour and astringent properties are astringent, while its sweet and slightly warming properties are tonic. It warms and nourishes the liver and kidneys, and also acts as astringent and firming agent, making it a warming, firming, and astringent herb. It is also said to tonify both kidney yang and kidney essence, serving as a yin-yang tonifying herb. It is primarily used to treat liver and kidney deficiency, kidney deficiency, excessive sweating, and metrorrhagia.

[0039] Chinese yam is sweet in taste and neutral in nature. It enters the spleen, lung and kidney meridians, replenishes qi and nourishes yin, tonifies the spleen, lungs and kidneys, astringes essence and stops leucorrhea. It is used to treat poor appetite, loose stools, excessive leucorrhea, wheezing and coughing due to lung deficiency, spermatorrhea due to kidney deficiency, leucorrhea, frequent urination, and thirst due to deficiency heat.

[0040] Magnolia officinalis is bitter and pungent in flavor, warm in nature, and enters the spleen, stomach, lung, and large intestine meridians. Its bitter, drying, dispersing, and warming properties dissipate dampness and food accumulation in the gastrointestinal tract, while also regulating qi stagnation. Therefore, it is an essential herb for treating abdominal distension and fullness caused by dampness, food accumulation, and qi stagnation. Entering the lung meridian, it can lower qi, eliminate phlegm and dampness, and relieve asthma. It is commonly used to treat cough, asthma, and excessive phlegm. It dries dampness, eliminates phlegm, and relieves qi and distension.

[0041] Citrus aurantium (Fructus Aurantii Immaturus) is bitter, pungent, and sour in flavor, with a slightly cold nature. It enters the spleen and stomach meridians. Its bitterness descends, while its pungentness disperses. It is slightly cold without being warming, and possesses a strong medicinal effect. It is effective in dispersing qi and eliminating stagnation to relieve distension, and also in promoting qi and dissolving phlegm to relieve abdominal distension. Therefore, it is a key herb for treating gastrointestinal stagnation and phlegm-induced chest pain. It can also treat organ prolapse. It disperses qi and eliminates stagnation, resolves phlegm, and relieves abdominal distension.

[0042] Dried ginger tastes pungent and hot in nature. It enters the spleen, stomach, kidney, heart, and lung meridians. It is pungent, hot, warm, and dispersing. It can not only dispel the cold evil of the spleen and stomach, but also help the yang energy of the spleen and stomach. It is an important medicine for warming the middle and dispelling cold. Regardless of whether it is real cold or false cold, it is suitable for entering the heart meridian. It can restore yang, dredge the meridians, warm the lungs and transform fluid, and is often used to treat cough and asthma caused by cold fluid.

[0043] Roasted Licorice root is sweet in taste and neutral in nature. It enters the Heart, Lung, Spleen, and Stomach meridians, nourishes the spleen and harmonizes the stomach, replenishes Qi and restores the pulse. It is used for spleen and stomach deficiency, fatigue, palpitations, and irregular pulses. It also harmonizes various other medicines.

[0044] Looking at the whole prescription, the present invention is based on "coordinating the five internal organs, and comprehensively treating them", and comprehensively distinguishing and treating them to improve and treat type 2 diabetes. The present invention uses raw rehmannia, astragalus, and white atractylodes as the main ingredients, which not only clear away heat and relieve restlessness, promote fluid production and replenish qi, but also enter the heart, liver, kidney, spleen, and lung meridians, and regulate the five internal organs; and uses salvia miltiorrhiza, chuanxiong, peach kernel, safflower, ginseng, and roasted aconite as the auxiliary ingredients respectively. Salvia miltiorrhiza, peach kernel, and safflower are used together to promote blood circulation and remove blood stasis, use ginseng to replenish qi and produce fluid and blood, use chuanxiong to promote blood circulation and promote qi, and use roasted aconite to replenish fire and support yang. The auxiliary ingredients are used together to unclog the three burners, help the main ingredients to achieve the smooth circulation of qi, blood, and body fluids, and restore the qi of the five internal organs. Recurrent epidemic; Cornus officinalis, Chinese yam, Magnolia officinalis, Citrus aurantium, and Poria are used as adjuvants. Cornus officinalis helps the main medicine to strengthen the kidney and circulate qi and blood. Chinese yam, Magnolia officinalis, and Citrus aurantium are used together to regulate the qi of the spleen and stomach and restore their normal transportation and transformation functions; Poria is used to calm the mind and help the main and auxiliary medicines to eliminate evil and restore the clarity of the heart and lungs. The adjuvants are used together to help the main and auxiliary medicines to circulate the triple energizer. Dried ginger and roasted licorice are used as guiding medicines. Roasted licorice is used to harmonize the various medicines, and dried ginger is used as the guiding medicine. The various medicines work together to achieve the effects of clearing away heat and relieving restlessness, promoting fluid production and replenishing qi, and circulating the triple energizer, coordinating the five internal organs, and comprehensively treating them to effectively improve and treat type 2 diabetes.

[0045] The present invention also has the effect of improving and treating complications of type 2 diabetes such as hyperlipidemia and hypertension. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Attachment Figure 1 The present invention is a flow chart of the preparation of water pills according to an embodiment of the present invention.

[0047] Attachment Figure 2Flow chart of the preparation of the powder according to the embodiment of the present invention. DETAILED DESCRIPTION

[0048] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0049] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0050] Example 1: A Chinese medicinal drug for improving the treatment of type 2 diabetes, which is prepared from the following raw materials by weight:

[0051] 45 parts of raw rehmannia root, 35 parts of astragalus root, 30 parts of atractylodes macrocephala, 20 parts of poria root, 30 parts of salvia miltiorrhiza, 25 parts of ligusticum chuanxiong, 20 parts of peach kernel, 30 parts of safflower, 25 parts of ginseng, 20 parts of processed aconite root, 20 parts of cornus officinalis, 25 parts of yam, 20 parts of magnolia bark, 20 parts of immature bitter orange, 15 parts of dried ginger, 10 parts of roasted liquorice root.

[0052] Example 2: A Chinese medicinal drug for improving the treatment of type 2 diabetes, which is prepared from the following raw materials by weight:

[0053] 50 parts of raw rehmannia root, 30 parts of astragalus root, 30 parts of white atractylodes, 30 parts of poria, 25 parts of salvia miltiorrhiza, 35 parts of chuanxiong, 18 parts of peach kernel, 35 parts of safflower, 30 parts of ginseng, 30 parts of roasted aconite root, 25 parts of cornus officinalis, 20 parts of yam, 30 parts of magnolia bark, 25 parts of immature bitter orange, 15 parts of dried ginger, 15 parts of roasted liquorice root.

[0054] The medicine of Example 1 or Example 2 can be prepared into oral water pills or powders.

[0055] The preparation process of water pills can be as follows Figure 1 As shown, the specific steps include:

[0056] (1) Take the raw drug according to the amount, sterilize and dry it, grind it separately and then sieve it;

[0057] When implementing this step:

[0058] Place the raw materials in a dynamic vacuum sterilizer, leaving appropriate gaps between the bags. The height should not exceed that of the inner bag. When the temperature reaches 115℃, start counting the time. The sterilization time is 30 minutes. After the time is up, dry for 20 to 40 minutes, take out and set aside.

[0059] The drug is crushed until all of it passes through the No. 8 sieve specified in the "Pharmacopoeia of the People's Republic of China: 2020 Edition", and no less than 95% of the drug powder passes through the No. 9 sieve.

[0060] (2) Mixing the crushed raw materials and stirring them evenly;

[0061] When implementing this step:

[0062] Place the sieved powder in a three-dimensional motion mixer and mix thoroughly for 30 minutes;

[0063] (3) Take Pueraria root, sterilize and dry it, crush it, add water, heat it and keep it for a period of time to make it fully gelatinized into a slurry, filter it, and use the filtrate as the excipient;

[0064] The sterilization, crushing and sieving of Pueraria root in this step are the same as those in step (1).

[0065] When implementing this step:

[0066] The sieved Pueraria root is added with 40-60% purified water according to its own weight, heated to 95°C (±2%) and maintained for 8 minutes to fully gelatinize into a slurry. The filtrate is filtered and placed in a sealed container as an excipient for later use.

[0067] (4) Mixing the medicine: Add the powder mixed evenly in step (2) to the excipient in step (3), and add water, mix and stir thoroughly to form a soft material, divide the soft material into uniform small pieces, let it cool, and then prepare pills;

[0068] In this step, the dosage ratio of the drug powder to the excipient is 1:(0.25-0.30);

[0069] The dosage ratio of excipient to water is 1:2.

[0070] The powder mixed evenly in step (2) is added to the excipient in step (3), and water is added, and the mixture is placed in a medicine mixing machine, and fully mixed and stirred for 3 to 5 minutes. The mixture is taken out, and the soft material is divided into uniform small pieces, cooled, and then prepared into pills.

[0071] (5) Pellet making: the soft material is made into pellets, and the surface of the pellets is processed to be round and smooth;

[0072] During the specific implementation of this step, according to the pill weight requirements, adjust the strip plate of the CNC high-efficiency automatic pill making machine, evenly feed the combined soft material into the feed port, start the machine, make qualified pellets through strip making and pill cutting, place the qualified pellets in the coating machine, add an appropriate amount of powder and 95% ethanol, grind for 10 minutes, until the surface of the pills is round and smooth, put them into the clean material tray, and set aside.

[0073] The mixture temperature is controlled at 80℃.

[0074] In a specific implementation, the weight of the water pill is 6g±7%.

[0075] (6) Dry and polish the pellets.

[0076] When this step is specifically implemented, the drying operation is as follows:

[0077] Place the pellets from step (5) in a hot air circulation oven at a drying temperature of 60-80°C. Turn the pellets frequently during the drying process to ensure that the pellets are evenly dried and have a consistent color.

[0078] Polishing: Place the dried pellets into a coating machine, add appropriate amount of 95% ethanol and refined honey and grind until smooth;

[0079] (7) The pellets can then be packaged.

[0080] Specifically, adjust the pill filling amount to 9g±7% and start the bag pressing machine (composite film), control the heat sealing temperature at (155-165℃ for horizontal sealing) (150-160℃ for vertical sealing), check the weight of the contents every hour, pick out unqualified products at any time, put the qualified medicines into clean containers, and deliver the outer packaging through the transfer window.

[0081] The preparation process of the powder can be as follows Figure 2 As shown, the method specifically includes the following steps:

[0082] (1) Take the raw drug according to the amount, sterilize and dry it, grind it separately and then sieve it;

[0083] When implementing this step:

[0084] Place the raw materials in a dynamic vacuum sterilizer, leaving appropriate gaps between the bags. The height should not exceed that of the inner bag. When the temperature reaches 115℃, start counting the time. The sterilization time is 30 minutes. After the time is up, dry for 20 to 40 minutes, take out and set aside.

[0085] The drug is crushed until all of it passes through the No. 8 sieve specified in the "Pharmacopoeia of the People's Republic of China: 2020 Edition", and no less than 95% of the drug powder passes through the No. 9 sieve.

[0086] (2) Mix the crushed raw materials, stir evenly, and then package them.

[0087] When implementing this step:

[0088] Place the sieved powder in a three-dimensional motion mixer and mix thoroughly for 30 minutes;

[0089] The specific packaging is 6g / bag.

[0090] The maximum daily dosage of the medicines in Example 1 and Example 2 is no more than 60 grams, three times a day, and no more than 20 grams each time.

[0091] Clinical application:

[0092] Treatment case: Case 1:

[0093]

[0094]

[0095] During the follow-up visit in April 2023, measurable values such as blood pressure and fasting blood sugar were all within normal range.

[0096]

[0097]

[0098] During the follow-up visit in July 2024, the blood pressure, fasting blood sugar and other measurable values were all within the normal range.

[0099]

[0100]

[0101] In the follow-up visit in December 2024, the blood pressure, blood sugar and other measurable values were all within the normal range. The following is a summary table of cases 4 to 40:

[0102]

[0103]

[0104]

[0105]

[0106]

[0107]

[0108]

[0109]

[0110]

[0111]

[0112]

[0113]

[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120] The present invention and its embodiments have been described, but such descriptions are not restrictive and the actual embodiments are not limited thereto. In short, if a person skilled in the art is inspired by the above and designs similar implementations and embodiments to the technical solution without departing from the purpose of the present invention, such implementations and embodiments shall fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine for improving the treatment of type 2 diabetes, characterized in that: It is made from the following raw materials by weight: 30-60 parts of raw Rehmannia root, 30-60 parts of Astragalus root, 15-45 parts of Atractylodes macrocephala, 15-45 parts of Poria root, 15-45 parts of Salvia miltiorrhiza, 15-45 parts of Chuanxiong, 12-36 parts of peach kernel, 12-36 parts of safflower, 12-36 parts of ginseng, 13-36 parts of roasted aconite root, 9-27 parts of Cornus officinalis, 9-27 parts of Chinese yam, 9-27 parts of Magnolia officinalis, 9-27 parts of Citrus aurantium, 6-18 parts of dried ginger, and 6-18 parts of roasted liquorice.

2. A Chinese medicine for improving the treatment of type 2 diabetes according to claim 1, characterized in that, It is made from the following raw materials by weight: 45 parts of raw rehmannia root, 35 parts of astragalus root, 30 parts of atractylodes macrocephala, 20 parts of poria root, 30 parts of salvia miltiorrhiza, 25 parts of ligusticum chuanxiong, 20 parts of peach kernel, 30 parts of safflower, 25 parts of ginseng, 20 parts of processed aconite root, 20 parts of cornus officinalis, 25 parts of yam, 20 parts of magnolia bark, 20 parts of immature bitter orange, 15 parts of dried ginger, 10 parts of roasted liquorice root.

3. A Chinese medicine for improving the treatment of type 2 diabetes according to claim 1, characterized in that, It is made from the following raw materials by weight: 50 parts of raw rehmannia root, 30 parts of astragalus root, 30 parts of white atractylodes, 30 parts of poria, 25 parts of salvia miltiorrhiza, 35 parts of chuanxiong, 18 parts of peach kernel, 35 parts of safflower, 30 parts of ginseng, 30 parts of roasted aconite root, 25 parts of cornus officinalis, 20 parts of yam, 30 parts of magnolia bark, 25 parts of immature bitter orange, 15 parts of dried ginger, 15 parts of roasted liquorice root.

4. A Chinese medicinal drug for improving the treatment of type 2 diabetes according to any one of claims 1 to 3, characterized in that: The traditional Chinese medicine is added with medically acceptable adjuvants to prepare an oral preparation.

5. A Chinese medicine for improving the treatment of type 2 diabetes according to claim 4, characterized in that, The oral preparation is a water pill, powder, tablet or capsule.

6. A method for preparing a water pill for improving the treatment of type 2 diabetes, characterized in that: The preparation is made from the Chinese medicinal material for improving the treatment of type 2 diabetes according to any one of claims 1 to 3 as a raw material, and the preparation method comprises the following steps: (1) Take the raw drug according to the amount, sterilize and dry it, grind it separately and then sieve it; (2) Mixing the crushed raw materials and stirring them evenly; (3) Sterilize and dry Pueraria root, crush it, add water, heat it for a period of time, and make it fully gelatinized into a slurry. After filtering, use the filtrate as the excipient; (4) Mixing the medicine: Add the powder mixed evenly in step (2) to the excipient in step (3), and add water, mix and stir thoroughly to form a soft material, divide the soft material into uniform small pieces, let it cool, and then prepare pills; (5) forming pellets from the soft material and treating the pellet surfaces to make them round and smooth; (6) Dry and polish the pellets.

7. The method for preparing a water pill for improving the treatment of type 2 diabetes according to claim 6, characterized in that: The dosage ratio of the medicinal powder to the excipient in step (4) is 1:(0.25-0.30).

8. The method for preparing a water pill for improving the treatment of type 2 diabetes according to claim 7, characterized in that: The ratio of excipient to water in step (4) is 1:

2.

9. Use of the traditional Chinese medicine for improving the treatment of type 2 diabetes according to any one of claims 1 to 3 in the preparation of a hypoglycemic preparation.

10. Use of the traditional Chinese medicine for improving the treatment of type 2 diabetes according to any one of claims 1 to 3 in the preparation of a preparation for improving the treatment of type 2 diabetes accompanied by hypertension or hyperlipidemia.

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