Directional traditional Chinese medicine transdermal application equipment

Abstract

The invention discloses directional traditional Chinese medicine transdermal application equipment, and relates to the technical field of biomedical engineering industries, the directional traditional Chinese medicine transdermal application equipment comprises a transdermal application part, the transdermal application part comprises an administration part and an application assembly, and the administration part presses and conveys medicine to the application assembly; the application assembly comprises a middle plate and a plurality of pyramid-shaped silica gel micro-protrusions which are arranged on the surface of the middle plate and distributed in an array mode, the up-down telescopic component stretches out and draws back to transmit force to the drug delivery component so that the silica gel micro-protrusions can be pressed to be tightly attached to the surface layer of the skin, and through the tip pressure gradient design of the silica gel micro-protrusions, the application effect is good on the premise that the completeness of the skin is not damaged. A cuticle lipid bilayer is promoted to generate reversible shear slippage, a loose pore channel with gradient pore diameter distribution is formed, pore diameters capable of directionally introducing the medicine are formed, and compared with a traditional plaster, the transdermal efficiency of the medicine is improved by multiple times; compared with a microneedle technology, the risk of dermis injury is avoided, and zero-wound drug delivery is achieved.

Description

Technical Field

[0001] The present application relates to the field of biomedical engineering industry, and in particular to a directional transdermal drug delivery device for traditional Chinese medicine. Background Art

[0002] Chinese medicine transdermal drug delivery equipment is a medical device that uses modern technology to transport the effective ingredients of Chinese medicine through the skin barrier and into the human body to achieve the purpose of treating diseases.

[0003] A Chinese patent with authorization announcement number CN104491980B discloses a traditional Chinese medicine transdermal drug administration therapeutic device, which includes a chip module capable of human-computer dialogue, data storage, instruction issuance, detection and control drive. The first output end of the module is connected to a time display for displaying the hot compress time, and the second output end of the module is connected to a temperature display for displaying the hot compress temperature. The control drive end of the module is connected to one end of a vacuum pump, and the other end of the vacuum pump is connected to a heating cup through an air duct. The heating cup is electrically connected to the module. Since the heating cup can both generate heat and generate negative pressure, it can implement cupping hot compress therapy, or one-suction-one-release (sucking) hot compress therapy, realizing a new two-in-one therapy of cupping and Chinese herbal hot compress therapy.

[0004] Transdermal drug delivery technology, as a new drug delivery method, has demonstrated significant advantages in the treatment of chronic diseases and topical drug delivery. However, existing technologies still face multiple bottlenecks in practical application: Traditional plasters rely on passive diffusion, resulting in low drug penetration efficiency, especially for ingredients with larger molecular weights. Microneedle puncture technology, while capable of increasing penetration, disrupts the skin barrier structure, poses infection risks, and is accompanied by significant pain, leading to poor patient compliance.

[0005] To this end, the present application proposes a directional transdermal Chinese medicine drug delivery device to solve the above problems. Summary of the Invention

[0006] In view of the above problems in the prior art, this application is proposed.

[0007] To solve the above technical problems, the present application provides the following technical solutions: a directional Chinese medicine transdermal drug administration device, which includes a base, a rotating arm group, upper and lower telescopic parts, a clamping part and a transdermal drug administration part; wherein the rotating arm group is fixed to a horizontal plane through the base; the upper and lower telescopic parts fix the end of the rotating arm group and realize horizontal rotation through the rotating arm group; the clamping part is hoisted on the upper and lower telescopic parts, and the clamping range of the clamping part is adjusted by the upper and lower telescopic parts. The transdermal drug administration part is clamped by the clamping part and pressed against the patient's back, the transdermal drug administration part includes a drug administration part and an application component, the drug administration part presses and delivers the drug to the application component, the application component includes an intermediate plate and a plurality of pyramid-shaped silicone micro-protrusions arranged in an array on the surface of the intermediate plate, the upper and lower telescopic parts are extended and retracted to transmit force to the drug administration part so that the silicone micro-protrusions are compressed and then tightly adhere to the surface of the skin, so that the lipid arrangement of the stratum corneum on the surface of the skin is loosened to form "honeycomb-like" channels.

[0008] As a preferred embodiment of the directional transdermal Chinese medicine drug delivery device described in the present application, the silicone micro-convexities include an outer shell layer, multiple sides of the outer shell layer are provided with micro-convex points, and the tips and micro-convex points of the outer shell layer are coated with stratum corneum softening enzyme.

[0009] As a preferred embodiment of the directional transdermal Chinese medicine drug delivery device described in the present application, the drug delivery component includes a drug delivery barrel and an outer armature plate, the outer armature plate is connected to the outer side of the bottom end of the drug delivery barrel, the drug delivery component also includes an air pump and an air pipe, the air pipe is connected to the air outlet end of the air pump, and the air in and out of the air pump is used to squeeze the liquid medicine in the drug delivery barrel out.

[0010] As a preferred solution of the directional Chinese medicine transdermal drug application device described in the present application, wherein: the transdermal drug application component also includes a pressure-dividing sealing component and a heat-releasing component, the pressure-dividing sealing component includes a first pressure-dividing member and a second pressure-dividing member, the first pressure-dividing member and the second pressure-dividing member are respectively arranged on both sides of the middle plate, the first pressure-dividing member is used to seal the gap between the middle plate and the surface layer of the skin, the second pressure-dividing member is used to seal the gap between the middle plate and the outer plate, the surface of the middle plate is provided with a plurality of rectangular through grooves distributed in an array, and the plurality of the rectangular through grooves correspond to the plurality of the silicone micro-protrusions.

[0011] As a preferred solution of the directional Chinese medicine transdermal drug administration device described in the present application, wherein: a filter membrane and a drug-loaded membrane are provided at each rectangular groove of the middle plate, wherein the drug-loaded membrane is provided on the side of the rectangular groove close to the silica gel micro-convexity; the filter membrane and the drug-loaded membrane are both designed with a multi-layer structure, and the surface of the filter membrane is provided with nano-pores of different pore sizes for intercepting ineffective macromolecules in the drug; the drug-loaded membrane is made of different materials to improve the transmittance of different components of the drug.

[0012] As a preferred solution of the directional Chinese medicine transdermal application device described in the present application, wherein: the first pressure-dividing member includes a lower silicone strip and a vacuum adsorption strip connected to the surface of the lower silicone strip, and the lower silicone strip forms a frame strip structure to enclose the lower surface of the middle plate; the second pressure-dividing member includes an upper silicone strip and a frame strip plate connected to the surface of the upper silicone strip, and the frame strip plate is connected to the outer yoke plate through the upper silicone strip.

[0013] As a preferred solution of the directional Chinese medicine transdermal application equipment described in the present application, wherein: the surface of the outer yoke plate is connected to a telescopic frame bar pressure plate, the telescopic frame bar pressure plate includes an upper frame pressure bar and a lower frame pressure bar, wherein the upper frame pressure bar is engaged and moved in the inner cavity of the lower frame pressure bar to adjust the length of the telescopic frame bar pressure plate, and a plurality of telescopic pressure rods are provided at the bottom of the outer yoke plate and the lower cylinder of the round cake, and the telescopic pressure rods and the telescopic frame bar pressure plate are synchronously extended and retracted.

[0014] As a preferred solution of the directional Chinese medicine transdermal drug delivery device described in the present application, the minimum height to which the retractable pressure rod and the retractable frame bar pressure plate can be retracted is the stacking height of the upper silicone strip and the frame bar plate.

[0015] As a preferred solution of the directional Chinese medicine transdermal drug delivery device described in the present application, the heat-releasing component includes two rectangular plates and a connecting rod, and the two rectangular plates are connected by the connecting rod.

[0016] As a preferred embodiment of the directional transdermal Chinese medicine drug delivery device described in the present application, the upper and lower telescopic components include a cylinder 1 and an actuator plate, the cylinder 1 is assembled on the rotating arm assembly, and the actuator plate is fixed to the bottom of the cylinder 1;

[0017] L-shaped grooves are provided at the relative positions of the outer yoke plate and the middle plate, and the two rectangular plates are rotatably connected in the L-shaped grooves. A temperature sensor is provided on the outer yoke plate, and a controller is provided on the cylinder 1. When the temperature sensor detects that the temperature of the drug transdermal leakage site increases, the controller controls the output end of the cylinder 1 to move upward.

[0018] The beneficial effects of the present application are as follows: the present application has multiple silicone micro-protrusions distributed in an array on the surface of the middle plate, and the silicone micro-protrusions adopt a pyramid-shaped structure. Through the pressure gradient design of the silicone micro-protrusion tips, without destroying the integrity of the skin, the stratum corneum lipid bilayer is prompted to produce reversible shear slip, forming loose channels with a pore size gradient distribution, and forming pores for the directionally introduced drug. Compared with traditional plasters, the drug transdermal efficiency is increased many times; compared with microneedle technology, the risk of dermal damage is avoided, and zero-wound drug delivery is achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0020] Figure 1 This is a schematic diagram of the overall structure of a directional transdermal Chinese medicine drug delivery device;

[0021] Figure 2 This is the overall structural axonometric drawing of the directional transdermal Chinese medicine drug delivery device;

[0022] Figure 3 This is a schematic diagram of the overall structure of the clamping component in this application;

[0023] Figure 4 This is a schematic diagram of the overall structure of the drug delivery component in this application;

[0024] Figure 5 This is a schematic diagram of the overall structure of the drug delivery cartridge in this application;

[0025] Figure 6 for Figure 5 A magnified view of the structure of part A;

[0026] Figure 7 This is a schematic diagram of the overall structure of the silicone micro-convex in this application;

[0027] Figure 8 This is a schematic diagram of the overall structure of the pressure-dividing sealing assembly in this application;

[0028] Figure 9 for Figure 8 Enlarged view of the structure of part B.

[0029] Explanation of reference numerals: 100, base; 200, rotating arm assembly; 210, first supporting arm; 220, second horizontal arm; 230, third rotating arm; 300, upper and lower telescopic components; 310, cylinder 1; 320, executive plate; 400, clamping component; 410, hanging plate; 420, clamping assembly; 421, positioning plate 2; 422, inner connecting cylinder; 423, outer pressing cylinder; 424, linkage rod; 425, gripping clamp; 430, driving assembly; 431, cylinder 2; 432, driving ring; 433, positioning plate 1; 500, transdermal drug delivery component; 510, drug delivery component; 511, drug delivery cylinder; 5111, conical upper cylinder; 5112, round lower cylinder; 5113, guide hole; 512, partition plate; 513, outer mortise plate; 51 4. Air pump; 515. Air tube; 516. Clamp; 520. Applicator assembly; 521. Silicone micro-convex; 5211. Outer shell; 5212. Inner shell; 5213. Connecting block; 5214. Micro-convex; 522. Intermediate plate; 5221. Rectangular through-slot; 5222. Filter membrane; 5223. Drug-loaded membrane; 530. Pressure-dividing sealing assembly; 531. First pressure-dividing component; 5311. Lower silicone strip; 5312. Vacuum adsorption strip; 532. Second pressure-dividing component; 5321. Upper silicone strip; 5322. Frame strip plate; 533. Telescopic frame strip pressure plate; 5331. Upper frame pressure strip; 5332. Lower frame pressure strip; 534. Telescopic pressure rod; 540. Heat release assembly; 541. Rectangular plate; 542. Connecting rod; 543. Temperature sensor. DETAILED DESCRIPTION

[0030] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the drawings in the specification.

[0031] In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present application. Therefore, the present application is not limited to the specific embodiments disclosed below.

[0032] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present application. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0033] Example 1

[0034] Reference Figures 1-9 As shown in the figure, it is the first embodiment of the present application, which provides a directional Chinese medicine transdermal drug delivery device, comprising:

[0035] The base 100 is disposed on a plane.

[0036] The rotating arm group 200 is fixed to a plane through the base 100. The rotating arm group 200 includes a first support arm 210, a second horizontal arm 220 and a third rotating arm 230. The first support arm 210 and the second horizontal arm 220, and the second horizontal arm 220 and the third rotating arm 230 are rotatably connected.

[0037] The upper and lower telescopic parts 300 fix the ends of the rotating arm group 200, and realize horizontal rotation through the rotating arm group 200. The upper and lower telescopic parts 300 include a cylinder 1 310 and an actuator plate 320. The cylinder 1 310 is assembled at one end of the third rotating arm 230 away from the second horizontal arm 220, and the actuator plate 320 is fixed to the bottom of the cylinder 1 310.

[0038] like Figure 2-Figure 3 As shown, the clamping member 400 is hoisted on the upper and lower telescopic members 300, and the clamping range of the clamping member 400 is adjusted by the telescopic movement of the upper and lower telescopic members 300;

[0039] The clamping component 400 includes a suspension plate 410, a clamping assembly 420, and a drive assembly 430. The drive assembly 430 includes a second cylinder 431, a drive ring 432, and a first positioning plate 433. The second cylinder 431 is fixed to the surface of the suspension plate 410 via the first positioning plate 433. The drive ring 432 is fixed to the surface of the output end of the second cylinder 431. The output end of the second cylinder 431 drives the drive ring 432 to reciprocate up and down.

[0040] The clamping assembly 420 includes a positioning plate 2 421, an inner connecting tube 422 and an outer pressing tube 423. A driving ring 432 is arranged at the top end of the outer pressing tube 423. A linkage rod 424 is arranged between the outer pressing tube 423 and the driving ring 432. The driving ring 432 that reciprocates up and down drives the outer pressing tube 423 to reciprocate up and down synchronously through the linkage rod 424; the inner connecting tube 422 is fixed to the suspension plate 410 through the positioning plate 2 421. A plurality of equally spaced annular mounting grooves are provided on the surface of the inner connecting tube 422. A grabbing clamp 425 is installed in the mounting groove. The plurality of grabbing clamps 425 are based on the central axis of the inner connecting tube 422 and are synchronously expanded or contracted at equal intervals and angles along the radial direction to achieve grabbing.

[0041] The transdermal drug delivery component 500 is clamped by the clamping component 400 and pressed against the patient's back. The transdermal drug delivery component 500 includes a drug delivery component 510 and an application component 520. The drug delivery component 510 presses and delivers the drug to the application component 520. The application component 520 includes a middle plate 522 and a plurality of pyramid-shaped silicone micro-protrusions 521 arranged in an array on the surface of the middle plate 522. The upper and lower telescopic components 300 extend and retract to transmit force to the drug delivery component 510 so that the silicone micro-protrusions 521 are compressed and closely adhered to the surface of the skin, so that the lipids in the stratum corneum of the surface of the skin are loosened to form "honeycomb-like" channels. Since the pyramid-shaped tips of the silicone micro-protrusions 521 preferentially contact the surface of the skin, the silicone micro-protrusions 521 are in contact with the surface of the skin. The pressure along the slope of 21 decreases gradually, forming a pore size gradient, so as to form a nano-scale lipid gap network concave texture on the surface of the skin, forming micron-scale pores of different pore sizes, so as to allow nano-scale drug molecules of different molecular weights to penetrate. The silicone micro-protrusions 521 have greatly improved the drug introduction efficiency compared with plaster dressings. Compared with the micron-scale penetrating micropores formed by microneedle puncture, which directly destroy the skin barrier structure, the present application uses the silicone micro-protrusions 521 to apply pressure to temporarily loosen the lipid bilayer of the stratum corneum, forming a natural lipid gap network mechanical stress loosened lipid layer, which is non-invasive and painless, greatly improving the drug transdermal efficiency while completely avoiding the pain and infection risks of traditional puncture technology.

[0042] This application uses the mechanical stress of the silicone micro-protrusions 521 to reversibly loosen the lipid bilayer of the stratum corneum without destroying the integrity of the skin, forming nano-scale penetration channels that are suitable for different molecular weights. Compared with microneedle puncture technology, it achieves non-invasive, painless, and high-precision compound delivery.

[0043] like Figure 7 As shown, the silicone micro-protrusion 521 includes an outer shell 5211 and an inner shell 5212. A drug delivery channel is formed between the outer shell 5211 and the inner shell 5212. Connecting blocks 5213 are provided at the four corners of the outer shell 5211 and the inner shell 5212. The outer shell 5211 and the inner shell 5212 are connected by the connecting blocks 5213. The inner shell 5212 and the connecting blocks 5213 reduce the inner cavity capacity of the outer shell 5211 to reduce the storage amount of the drug in the inner cavity of the outer shell 5211.

[0044] Micro-bumps 5214 are provided on the four sides of the outer shell layer 5211. The tip of the outer shell layer 5211 and the micro-bumps 5214 on the side of the outer shell layer 5211 are coated with keratin softening enzyme to release and degrade keratin under pressure to further expand the pores. The multiple micro-bumps 5214 on the side of the outer shell layer 5211 realize multiple stress points, effectively forming multiple effective stress points on the surface of the skin, compressing the surface of the skin to form pores for the directional introduction of drugs.

[0045] like Figure 4 and Figure 5 As shown, the drug delivery component 510 includes a drug delivery cylinder 511, a partition plate 512, and an outer keeper plate 513. The drug delivery cylinder 511 includes a conical upper cylinder 5111 and a circular lower cylinder 5112 connected as an integral body. The outer keeper plate 513 is mounted on the bottom end of the circular lower cylinder 5112. A plurality of guide holes 5113 are formed on the surface of the circular lower cylinder 5112. The partition plate 512 is disposed in the inner cavity of the drug delivery cylinder 511 and is guided by the conical upper cylinder 5111. It moves along the axis of the conical upper cylinder 5111 and moves toward the circular lower cylinder 5112 to squeeze the drug solution into the guide holes 5113.

[0046] The conical upper cylinder 5111 is divided into an air cavity and a liquid medicine cavity by a partition plate 512. The partition plate 512 pushes the liquid medicine in the liquid medicine cavity into the guide hole 5113.

[0047] The drug delivery component 510 further includes an air pump 514 and an air tube 515. The air tube 515 is connected to the air outlet end of the air pump 514 and its other end is connected to the end of the conical upper cylinder 5111 facing away from the circular lower cylinder 5112. The air pump 514 increases the air volume in the air cavity to push the partition plate 512 toward the circular lower cylinder 5112 to deliver the drug solution.

[0048] A plurality of clamps 516 are fixed to the outer surface of the dosing barrel 511 , and the air pump 514 is assembled to the outer surface of the dosing barrel 511 through the clamps 516 .

[0049] like Figure 2 、 Figure 4-Figure 6 、 Figure 8-Figure 9 As shown, the transdermal drug dispensing component 500 also includes a pressure-dividing sealing component 530 and a heat-releasing component 540. The pressure-dividing sealing component 530 includes a first pressure-dividing member 531 and a second pressure-dividing member 532. The first pressure-dividing member 531 and the second pressure-dividing member 532 are respectively arranged on both sides of the middle plate 522. The first pressure-dividing member 531 is used to seal the gap between the middle plate 522 and the surface layer of the skin, and the second pressure-dividing member 532 is used to seal the gap between the middle plate 522 and the outer armature plate 513. The surface of the middle plate 522 is provided with a plurality of rectangular through grooves 5221 distributed in an array, and the plurality of rectangular through grooves 5221 correspond to the plurality of silicone micro-protrusions 521.

[0050] like Figure 5 and Figure 6 A filter membrane 5222 and a drug-loaded membrane 5223 are provided at each rectangular groove 5221 of the middle plate 522, wherein the drug-loaded membrane 5223 is provided on the side of the rectangular groove 5221 close to the silicone micro-protrusion 521; the filter membrane 5222 and the drug-loaded membrane 5223 are both designed with a multi-layer structure, and the surface of the filter membrane 5222 is provided with nano-pores of different pore sizes for intercepting ineffective macromolecules in the drug; the drug-loaded membrane 5223 is made of different materials to improve the transmittance of different components of the drug.

[0051] Specifically, the filter membrane 5222 is composed of a surface membrane, a middle membrane and a bottom membrane from top to bottom. The nanopores on the surface of the surface membrane have a pore size of 50nm, the nanopores on the surface of the middle membrane have a pore size of 20nm, and the nanopores on the surface of the bottom membrane have a pore size of 2nm. Through the coordinated filtration of the surface membrane, the middle membrane and the bottom membrane, the precipitation and stratification of components are eliminated, and the efficacy of the original prescription is retained; the drug-loaded membrane 5223 is divided into a hydrophilic layer, an amphiphilic layer and a hydrophobic layer from top to bottom. The hydrophilic layer loads polar components such as alkaloids, Polysaccharides, including sodium alginate hydrogel, are preferentially released through capillary action. The amphiphilic layer is loaded with moderately polar components such as flavonoid glycosides. A chitosan-lipid composite membrane is used to control the release by utilizing the osmotic pressure difference. The hydrophobic layer is loaded with non-polar components such as volatile oils, which diffuse through a microporous silica carrier relying on a concentration gradient. The filter membrane 5222 and the drug-loaded membrane 5223 are used to solve the three-level synergy of "physical screening-chemical controlled release-bioadaptation", breaking through the problems of component interference and low efficiency in the transdermal delivery of compound Chinese medicines.

[0052] like Figure 8-Figure 9 As shown, the first pressure-dividing member 531 includes a lower silicone strip 5311 and a vacuum adsorption strip 5312 connected to the surface of the lower silicone strip 5311. The lower silicone strip 5311 forms a frame strip structure to enclose the lower surface of the middle plate 522. The second pressure-dividing member 532 includes an upper silicone strip 5321 and a frame strip plate 5322 connected to the surface of the upper silicone strip 5321. The frame strip plate 5322 is connected to the outer armature plate 513 through the upper silicone strip 5321.

[0053] like Figure 8-Figure 9 As shown, the surface of the outer mortise plate 513 is connected to a telescopic frame strip pressure plate 533, and the telescopic frame strip pressure plate 533 includes an upper frame pressure strip 5331 and a lower frame pressure strip 5332, wherein the upper frame pressure strip 5331 is engaged and moved in the inner cavity of the lower frame pressure strip 5332 to adjust the length of the telescopic frame strip pressure plate 533, and the bottom of the outer mortise plate 513 and the round cake lower cylinder 5112 are provided with a plurality of telescopic pressure rods 534, and the telescopic pressure rods 534 and the telescopic frame strip pressure plate 533 are synchronously retracted, and the minimum height to which the telescopic pressure rods 534 and the telescopic frame strip pressure plate 533 can be retracted is the superimposed height of the upper silicone strip 5321 and the frame strip plate 5322;

[0054] Among them, the upper frame pressure strip 5331 is fixed to the surface of the outer frame plate 513, the lower frame pressure strip 5332 is fixed to the surface of the middle plate 522, one end of the telescopic pressure rod 534 is fixed to the middle plate 522, and the other end is fixed to the outer frame plate 513 or the round lower tube 5112. There are multiple telescopic pressure rods 534, which are arrayed on the middle plate 522 and avoid the position of the rectangular through groove 5221.

[0055] Example 2

[0056] Reference Figure 8-Figure 9 , which is the second embodiment of the present application, is based on the previous embodiment, except that the heat-releasing assembly 540 includes two rectangular plates 541 and a connecting rod 542 , and the two rectangular plates 541 are connected by the connecting rod 542 .

[0057] Among them, L-shaped grooves are opened at the relative positions of the outer armature plate 513 and the middle plate 522. Two rectangular plates 541 are rotatably connected in the L-shaped grooves. The outer armature plate 513 is equipped with a temperature sensor 543, and the cylinder 1 310 is equipped with a controller. When the temperature sensor 543 detects that the temperature of the drug transdermal leakage site increases, the controller controls the output end of the cylinder 1 310 to move upward.

[0058] A vibrator is also fixed on the surface of the outer compression cylinder 423 .

[0059] Working principle: Manually push the second horizontal arm 220 and the third rotating arm 230 to rotate the third rotating arm 230 to the target skin area, start the cylinder 1 310 to press the clamping component 400 and the transdermal applicator 500 downward, turn on the vibrator, and transmit the vibration to the transdermal applicator 500 through the external compression cylinder 423. The downward pressing position of the clamping component 400 and the transdermal applicator 500 is specifically determined according to the patient's own feelings.

[0060] The pyramid tips of the silica microprotrusions 521 generate a certain pressure on the surface of the skin, forcing the lipid bilayer of the stratum corneum to shear slip, forming loose channels with a pore size gradient distribution, and further expanding the pore size of the channels through stratum corneum softening enzymes, thereby improving the directional transdermal efficiency of drugs.

[0061] Air pump 514 injects compressed air into the air cavity of conical upper tube 5111, pushing partition plate 512 toward circular lower tube 5112, squeezing the compound Chinese herbal extract from the liquid medicine cavity. The liquid medicine flows evenly through guide holes 5113 in circular lower tube 5112, passing through filter membrane 5222 and drug-loaded membrane 5223 in sequence, ensuring efficient and rapid drug penetration.

[0062] The telescopic frame pressure plate 533 automatically adapts to varying body surface curvatures by nesting and expanding the upper frame pressure bar 5331 and the lower frame pressure bar 5332. The telescopic pressure rod 534 works in conjunction with the frame pressure plate 533 to adjust pressure distribution in real time as the patient's position changes. This ensures consistent pressure from the multiple silicone micro-protrusions 521 squeezing the skin surface, preventing excessive pressure and creating more effective channels for improved drug delivery.

[0063] When the temperature sensor 543 detects that the temperature of the skin surface is too high, the controller controls the output end of the cylinder 310 to move upward, so that the clamping component 400 and the transdermal applicator 500 move upward, the vacuum adsorption strip 5312 is adsorbed on the skin surface, the telescopic frame bar pressure plate 533 and the telescopic pressure rod 534 are passively extended, and the upward-moving round cake lower cylinder 5112 and the outer yoke plate 513 pull the middle plate 522 through the telescopic frame bar pressure plate 533 and the telescopic pressure rod 534, so that the silicone micro-protrusion 521 reduces the pressure applied to the skin surface; secondly, the distance between the outer yoke plate 513 and the middle plate 522 increases, and the two rectangular plates 541 are respectively installed in the L-shaped grooves of the outer yoke plate 513 and the middle plate 522. The two rectangular plates 541 are flipped by the pull of the connecting rod 542, and the hot air is exchanged with the outside world through the L-shaped groove.

[0064] After the preset dosing time is complete, the edge of the vacuum strip 5312 is moved to release it from the skin's surface. The controller then controls cylinder 1 310 to drive the clamping component 400 and transdermal applicator 500 further upward to a predetermined position. Cylinder 2 431 pulls the drive ring 432 upward, which in turn drives the outer compression cylinder 423 upward via the linkage rod 424. The gripper 425 simultaneously deploys along the mounting groove of the inner connecting cylinder 422, releasing the transdermal applicator 500. Cylinder 1 310 drives the actuator plate 320 upward, and the rotating arm assembly 200 is manually pushed to automatically return to its initial position, completing the entire dosing cycle.

[0065] Of course, the above content is only a preferred embodiment of the present application and cannot be considered to limit the scope of the embodiments of the present application. The present application is not limited to the above examples. Equal changes and improvements made by ordinary technicians in this technical field within the substantive scope of the present application should all fall within the scope of the patent application.

[0066] Finally, a few points should be explained: First, in the description of this application, it should be noted that, unless otherwise specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense, and may refer to mechanical or electrical connections, internal communication between two components, or direct connection. "Up," "down," "left," and "right" are only used to indicate relative positional relationships. When the absolute positions of the objects being described change, the relative positional relationships may also change.

[0067] Secondly: The drawings of the embodiments disclosed in this application only involve structures related to the embodiments disclosed in this application. Other structures can refer to general designs. In the absence of conflicts, the same embodiment and different embodiments of this application can be combined with each other.

[0068] Finally: The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. A directional transdermal Chinese medicine drug delivery device, characterized in that: include: A base (100) connected to a rotating arm assembly (200); An upper and lower telescopic member (300) fixes the end of the rotating arm group (200) and realizes horizontal rotation through the rotating arm group (200); A clamping component (400) is hoisted on the upper and lower telescopic components (300), and the clamping range of the clamping component (400) is adjusted by the telescopic movement of the upper and lower telescopic components (300); A transdermal drug delivery component (500) is clamped by a clamping component (400) and pressed against the back of a patient. The transdermal drug delivery component (500) includes a drug delivery component (510) and an application component (520). The drug delivery component (510) presses and delivers drugs to the application component (520). The application component (520) includes an intermediate plate (522) and a plurality of pyramid-shaped silicone micro-protrusions (521) arranged in an array on the surface of the intermediate plate (522). The upper and lower telescopic components (300) telescope to transmit force to the drug delivery component (510) so that the silicone micro-protrusions (521) are compressed and closely adhered to the surface of the skin, thereby loosening the arrangement of the stratum corneum lipids in the surface of the skin to form "honeycomb-like" channels.

2. The directional transdermal Chinese medicine applicator according to claim 1, characterized in that: The silica gel micro-protrusion (521) comprises an outer shell layer (5211), multiple side surfaces of the outer shell layer (5211) are provided with micro-protrusions (5214), and the tip of the outer shell layer (5211) and the micro-protrusions (5214) are coated with cuticle softening enzyme.

3. The directional transdermal Chinese medicine applicator according to claim 2, characterized in that: The drug delivery component (510) includes a drug delivery barrel (511) and an outer mortise plate (513), wherein the outer mortise plate (513) is connected to the outer side of the bottom end of the drug delivery barrel (511). The drug delivery component (510) further includes an air pump (514) and an air pipe (515), wherein the air pipe (515) is connected to the air outlet end of the air pump (514), and the air in and out of the air pump (514) is used to squeeze the liquid medicine in the drug delivery barrel (511) and discharge it.

4. The directional transdermal Chinese medicine applicator according to claim 3, characterized in that: The transdermal drug dispensing component (500) further includes a pressure-dividing sealing assembly (530) and a heat-releasing assembly (540). The pressure-dividing sealing assembly (530) includes a first pressure-dividing member (531) and a second pressure-dividing member (532). The first pressure-dividing member (531) and the second pressure-dividing member (532) are respectively arranged on both sides of the middle plate (522). The first pressure-dividing member (531) is used to seal the gap between the middle plate (522) and the surface layer of the skin, and the second pressure-dividing member (532) is used to seal the gap between the middle plate (522) and the outer plate (513). The surface of the middle plate (522) is provided with a plurality of rectangular through grooves (5221) distributed in an array, and the plurality of rectangular through grooves (5221) correspond to the plurality of silicone micro-protrusions (521).

5. The directional transdermal Chinese medicine drug delivery device according to claim 4, characterized in that: A filter membrane (5222) and a drug-loaded membrane (5223) are provided at each rectangular through groove (5221) of the middle plate (522), wherein the drug-loaded membrane (5223) is provided on a side of the rectangular through groove (5221) close to the silica gel micro-protrusion (521); the filter membrane (5222) and the drug-loaded membrane (5223) are both designed as a multi-layer structure.

6. The directional transdermal Chinese medicine drug delivery device according to claim 5, characterized in that: The first pressure-dividing member (531) includes a lower silicone strip (5311) and a vacuum adsorption strip (5312) connected to the surface of the lower silicone strip (5311), wherein the lower silicone strip (5311) forms a frame strip structure to enclose the lower surface of the middle plate (522); the second pressure-dividing member (532) includes an upper silicone strip (5321) and a frame strip plate (5322) connected to the surface of the upper silicone strip (5321), wherein the frame strip plate (5322) is connected to the outer mortise plate (513) via the upper silicone strip (5321).

7. The directional transdermal Chinese medicine drug delivery device according to claim 6, characterized in that: The surface of the outer yoke (513) is connected to a telescopic frame strip pressure plate (533), and the telescopic frame strip pressure plate (533) includes an upper frame pressure strip (5331) and a lower frame pressure strip (5332), wherein the upper frame pressure strip (5331) is engaged and moved in the inner cavity of the lower frame pressure strip (5332) to adjust the length of the telescopic frame strip pressure plate (533). The bottom of the outer yoke (513) and the round cake lower cylinder (5112) are provided with a plurality of telescopic pressure rods (534), and the telescopic pressure rods (534) and the telescopic frame strip pressure plate (533) are synchronously extended and retracted.

8. The directional transdermal Chinese medicine drug delivery device according to claim 7, characterized in that: The minimum height to which the telescopic pressure rod (534) and the telescopic frame strip pressure plate (533) are retracted is the superimposed height of the upper silica gel strip (5321) and the frame strip plate (5322).

9. The directional transdermal Chinese medicine drug delivery device according to claim 8, characterized in that: The heat release assembly (540) comprises two rectangular plates (541) and a connecting rod (542), and the two rectangular plates (541) are connected via the connecting rod (542).

10. The directional transdermal Chinese medicine drug delivery device according to claim 9, characterized in that: The vertical telescopic component (300) includes a cylinder (310) and an actuator plate (320), wherein the cylinder (310) is assembled on the rotating arm assembly (200), and the actuator plate (320) is fixed to the bottom of the cylinder (310); L-shaped grooves are provided at relative positions of the outer yoke plate (513) and the middle plate (522), and the two rectangular plates (541) are rotatably connected in the L-shaped grooves. The outer yoke plate (513) is equipped with a temperature sensor (543), and the cylinder one (310) is equipped with a controller. When the temperature sensor (543) detects that the temperature of the drug transdermal leakage site increases, the controller controls the output end of the cylinder one (310) to move upward.

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