Oxidized aporphine and biguanide derivative mixed rhodium complex as well as synthesis method and application thereof

By mixing rhodium (III) metal ions with oxidized apofen and biguanide derivatives, the rhodium complexes Rh-Met and Rh-Phen are formed, which solves the problem of rhodium complexes lacking hypoglycemia and anti-tumor effects in the prior art, and achieves significant inhibition of tumor cells and reduction of blood sugar levels under high sugar conditions.

CN120535558APending Publication Date: 2025-08-26GUANGXI NORMAL UNIV
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Patent Information

Application Number
CN202510621106.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-14
Publication Date
2025-08-26

AI Technical Summary

Technical Problem

The prior art lacks rhodium complexes that have both hypoglycemia and anti-tumor effects, especially mixtures of oxidized apoflox and biguanide derivatives, and the existing metformin has severe toxic side effects at high doses.

Method used

The rhodium (III) metal ions are mixed with oxidized apophene and biguanide derivatives to form mixed rhodium complexes Rh-Met and Rh-Phen. A specific ratio of metformin hydrochloride or phenethyl phenysteine ​​hydrochloride and oxidized apophene in a mixed solvent are used to control the temperature and time to obtain a complex with novel structure.

Benefits of technology

Under high sugar conditions, the proliferation of multiple tumor cells was significantly inhibited, and the blood sugar level was simultaneously reduced in the tumor model of type 2 diabetes combined with tumor, showing good dual effects of inhibiting tumor growth and lowering blood sugar.

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Abstract

The invention discloses two rhodium complexes mixed by oxoaporphine and biguanide derivatives as well as a synthesis method and application of the rhodium complexes, and belongs to the technical field of medicines. The synthesis method of the rhodium complex comprises the following steps: placing aporphine oxide, rhodium chloride hydrate and metformin hydrochloride or phenformin hydrochloride which is excessive relative to the aporphine oxide into a reaction container, adding a mixed solvent, and reacting under a heating condition to obtain a complex Rh-Met or Rh-Phen; wherein the mixed solvent is a composition composed of acetonitrile and methanol according to a volume ratio of (1-2): (1-3). Test results of the applicant show that the compound has a good inhibition effect on various tumor cell strains, has dual effects of inhibiting tumor growth and reducing blood sugar level in a mouse experiment of a type 2 diabetes mellitus combined tumor model, and is expected to be used as a therapeutic drug for diabetes mellitus combined tumor patients.
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