A kind of phenformin cr (iii) complex and its preparation method and application

Abstract

The invention particularly relates to a phenformin Cr(III) complex as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out micro heating and stirring on phenformin hydrochloride and sodium hydroxide according to the mole ratio being 1 to 1 by using water and alcohol for dissolving; slowly dropwise adding a chromium salt aqueous solution in a stirring process; after the operation of dropwise adding is finished, carrying out micro heating and stirring for a period of time, stopping reaction, and standing for 2 hours; filtering and washing to obtain a red powder product. The phenformin Cr(III) complex disclosed by the invention has the advantages of easiness in absorption, high efficiency and no toxicity, and can be used for preparing a medicine for reducing blood sugar and losing weight.

Description

technical field

[0001] The invention belongs to the technical field of metal complexes and their preparation methods and applications, in particular to a phenformin Cr(III) complex and its preparation methods and applications. Background technique

[0002] A large number of literatures at home and abroad have shown that Cr(III) complexes show a more important synergistic effect in the treatment of type 2 diabetes (T2D), and Cr(III) ions have the ability to enhance insulin, promote sugar, protein and lipid metabolism. metabolism. Therefore, supplementing an appropriate amount of Cr(III) to diabetics can enhance the action of insulin and reduce blood sugar, blood lipids and serum cholesterol levels. In addition, phenformin hydrochloride can reduce the decomposition of glycogen and promote the synthesis of muscle sugar, thereby lowering blood sugar. It is an effective drug for treating adult non-insulin-dependent diabetes and some insulin-dependent diabetes. In addition, the ...

Examples

Embodiment 1

[0027] A kind of phenformin Cr (III) complex in the present embodiment, its structural formula is:

[0028]

[0029] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0030] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1 in a molar ratio of 1:1, stir and dissolve at a temperature of 30°C; add the water and ethanol mixture The amount is 20 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0031] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.5mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 50 drops / per minute In the said step, the molar ratio of the amount of chromium trichloride to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 30°C for 30min, stop the reaction, let stand for 2h, filter, Aft...

Embodiment 2

[0033] The phenformin Cr(III) complex in this example is the same as that in Example 1.

[0034] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0035] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1.5 in a molar ratio of 1:1, stir and dissolve at a temperature of 35°C; add the water and ethanol mixture The amount is 30 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0036] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.8mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 60 drops / per minute Among them, the molar ratio of the amount of chromium trichloride in the step to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 35°C for 60min, stop the reaction, let stand for 2h, filter, After the solid wa...

Embodiment 3

[0038] The phenformin Cr(III) complex in this example is the same as that in Example 1.

[0039] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0040] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1.3 in a molar ratio of 1:1, stir and dissolve at a temperature of 32°C; add the water and ethanol mixture The amount is 25 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0041] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.7mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 55 drops / per minute In the said step, the molar ratio of the amount of chromium trichloride to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 32°C for 50min, stop the reaction, let stand for 2h, filter, After the solid was wash...

technical field

[0001] The invention belongs to the technical field of metal complexes and their preparation methods and applications, in particular to a phenformin Cr(III) complex and its preparation methods and applications. Background technique

[0002] A large number of literatures at home and abroad have shown that Cr(III) complexes show a more important synergistic effect in the treatment of type 2 diabetes (T2D), and Cr(III) ions have the ability to enhance insulin, promote sugar, protein and lipid metabolism. metabolism. Therefore, supplementing an appropriate amount of Cr(III) to diabetics can enhance the action of insulin and reduce blood sugar, blood lipids and serum cholesterol levels. In addition, phenformin hydrochloride can reduce the decomposition of glycogen and promote the synthesis of muscle sugar, thereby lowering blood sugar. It is an effective drug for treating adult non-insulin-dependent diabetes and some insulin-dependent diabetes. In addition, the ...

Examples

Embodiment 1

[0027] A kind of phenformin Cr (III) complex in the present embodiment, its structural formula is:

[0028]

[0029] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0030] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1 in a molar ratio of 1:1, stir and dissolve at a temperature of 30°C; add the water and ethanol mixture The amount is 20 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0031] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.5mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 50 drops / per minute In the said step, the molar ratio of the amount of chromium trichloride to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 30°C for 30min, stop the reaction, let stand for 2h, filter, Aft...

Embodiment 2

[0033] The phenformin Cr(III) complex in this example is the same as that in Example 1.

[0034] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0035] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1.5 in a molar ratio of 1:1, stir and dissolve at a temperature of 35°C; add the water and ethanol mixture The amount is 30 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0036] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.8mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 60 drops / per minute Among them, the molar ratio of the amount of chromium trichloride in the step to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 35°C for 60min, stop the reaction, let stand for 2h, filter, After the solid wa...

Embodiment 3

[0038] The phenformin Cr(III) complex in this example is the same as that in Example 1.

[0039] A method for preparing said phenformin Cr (III) complex, comprising the steps of:

[0040] 1) Add phenformin hydrochloride and sodium hydroxide into a mixture of water and ethanol with a volume ratio of 1:1.3 in a molar ratio of 1:1, stir and dissolve at a temperature of 32°C; add the water and ethanol mixture The amount is 25 times of the total mass of phenformin hydrochloride and sodium hydroxide;

[0041] 2) Dissolve chromium trichloride in water to obtain a chromium trichloride solution with a concentration of 0.7mol / L, and slowly add the chromium trichloride solution to the solution prepared in step 1) at a rate of 55 drops / per minute In the said step, the molar ratio of the amount of chromium trichloride to the amount of phenformin hydrochloride in step 1) is: 1:3; Stir at a temperature of 32°C for 50min, stop the reaction, let stand for 2h, filter, After the solid was wash...

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