Silk fibroin tea polyphenol hydrogel as well as preparation method and application thereof

By preparing silk fibroin tea polyphenol hydrogel and taking advantage of its close fit and molecular reaction with bladder tissue, the treatment problem of hemorrhagic cystitis was solved, and personalized, effective hemostatic effect and non-toxic side effect treatment were achieved.

CN120603578AActive Publication Date: 2025-09-05NINGBO FIRST HOSPITAL
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Patent Information

Application Number
CN202480006510.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-15
Publication Date
2025-09-05
Estimated Expiration
2044-10-15

AI Technical Summary

Technical Problem

Existing treatments for hemorrhagic cystitis have problems such as drug and antibiotic abuse, increased drug resistance, limited symptomatic treatment effects, and frequent recurrences. There is a need to develop more personalized and effective treatments.

Method used

Silk fibroin-tea polyphenol hydrogel is prepared by combining silk fibroin and tea polyphenols, cross-linking with ultraviolet light to form a hydrogel, and gelling in situ at the lesion site to achieve close adhesion to the bladder tissue. The urea in urine is used to change the molecular reaction to achieve a hemostatic effect.

Benefits of technology

Silk fibroin tea polyphenol hydrogel has good adhesion, tensile and compressive properties, and can completely treat hemorrhagic cystitis without toxic side effects, reduce recurrence, and significantly improve the treatment effect.

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Abstract

The invention discloses silk fibroin tea polyphenol hydrogel as well as a preparation method and application thereof. The silk fibroin tea polyphenol hydrogel is prepared by adopting the following method: (S10) preparing silk fibroin; (S20) preparation of silk fibroin hydrogel: irradiating the aqueous solution of the SFMA and the LAP under ultraviolet light to prepare the SFMA hydrogel; and (S30) preparing the silk fibroin tea polyphenol hydrogel. When the hydrogel is applied, TP is injected into the bladder, then the SFMA hydrogel is injected, light curing is carried out, and the silk fibroin tea polyphenol hydrogel is formed on the bladder wall. The prepared silk fibroin tea polyphenol hydrogel is suitable for being applied to treatment of hemorrhagic cystitis, is good in adhesion and has a good hemostatic effect.
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