Preparation method of edible mushroom formula food with specific medical application

Abstract

The invention discloses a preparation method of edible mushroom formula food with specific medical application, and relates to the technical field of preparation of edible mushroom formula food. The edible mushroom formula food with the specific medical application is prepared from the following raw materials in parts by weight: 20 to 30 grams of edible mushroom compound extract, 25 to 35 grams of whey protein hydrolysate, 10 to 20 grams of medium chain triglyceride, 5 to 10 grams of resistant dextrin, 3 to 8 grams of fructo-oligosaccharide, 0.5 to 2 grams of compound vitamin mineral, 0.1 to 0.5 gram of curcumin microencapsulated powder and 0.1 to 1 gram of natural vanilla flavor agent. According to the preparation method of the edible mushroom formula food for the specific medical purpose, the absorption rate of hydrolyzed whey protein reaches 90% or above, the energy supply efficiency of MCT is improved by 3 times compared with that of long-chain fatty acid, energy is supplied rapidly, absorption is easy, low-GI resistant dextrin and prebiotics are adopted, blood sugar is stabilized, and intestinal health is promoted.

Description

Technical Field

[0001] The present invention relates to the technical field of preparation of edible fungus formula food, in particular to a method for preparing edible fungus formula food for specific medical purposes. Background Art

[0002] Formulated foods for specific medical purposes, as an important part of clinical nutritional support, play an irreplaceable role in the modern medical system. For patients with chronic diseases such as diabetes, kidney disease, and tumors, conventional diets are difficult to meet their special nutritional needs. Formulated foods for specific medical purposes can effectively improve patients' metabolic disorders by precisely regulating the ratio of macronutrients and micronutrients. For example, formulated foods for specific medical purposes for diabetic patients can slow the rate of blood sugar rise after meals by optimizing the types and proportions of carbohydrates; low-protein formula foods designed for kidney patients can not only meet basic nutritional needs, but also reduce the metabolic burden on the kidneys and delay disease progression; during the perioperative period and chemotherapy, patients often experience restricted food intake and digestion and absorption disorders. Formulated foods for specific medical purposes can provide them with high-energy, easily digestible nutritional support to accelerate the body's recovery.

[0003] Formulated edible fungi foods for specific medical purposes are specially processed and formulated to meet the specific nutrient or dietary needs of people with restricted food intake, digestive and absorption disorders, metabolic disorders, or specific disease states. These foods should be used under the guidance of a doctor or clinical nutritionist.

[0004] Users include those recovering from surgery, those with digestive system diseases, and those with weakened immune systems. Different disease states require different nutritional support. For example, postoperative patients may require a high-protein, easily digestible formula, while those with metabolic disorders may require a low-sugar, low-fat formula.

[0005] Edible fungi, as one of the main ingredients, offer numerous health benefits, such as being rich in polysaccharides, dietary fiber, protein, vitamins, and minerals. Different types of edible fungi have distinct functional properties. For example, shiitake mushrooms contain lentinan, which has immunomodulatory effects; Ganoderma lucidum contains triterpenoids, which have antioxidant and anti-inflammatory properties; and Hericium erinaceus, which supports digestive health.

[0006] In combination with specific medical purposes, appropriate types of edible fungi are selected and combined with other nutrients to ensure the scientific nature and effectiveness of the formula. At the same time, the palatability, stability and safety of the food also need to be considered. For example, shiitake mushrooms are rich in polysaccharides and proteins, which help regulate the immune system; Ganoderma lucidum has anti-inflammatory and antioxidant effects; Hericium erinaceus helps digestion and protects the gastric mucosa. To supplement high-quality protein, you can consider whey protein or soy protein isolate; to promote digestion and absorption, you can add prebiotics such as oligofructose; to provide essential fatty acids, you can add medium-chain triglycerides (MCT); vitamins and minerals need to be comprehensive, especially nutrients that contribute to immune function, such as vitamin C, vitamin D, zinc and selenium.

[0007] The formulation also needs to consider the form of the food, such as powder, liquid or semi-solid. Powders are easy to store and mix, which is suitable for postoperative patients who may need to be fed through a tube or take oral supplements.

[0008] In terms of proportions, it is necessary to ensure that the ratio of various nutrients complies with the national standards for special medical purpose formula foods, such as GB29922-2013. For example, the protein content must account for an appropriate proportion of the total energy, and the ratio of fat to carbohydrates must also meet the standards.

[0009] The processing method of edible fungi also needs to be considered. Edible fungi need to go through processes such as drying and crushing to ensure the retention of active ingredients and product stability. Stabilizers or antioxidants may also need to be added to extend shelf life.

[0010] In terms of safety, it is imperative to ensure that all raw materials meet food safety standards and are free of heavy metal contamination, pesticide residues, and other issues. Edible fungi, in particular, are natural products, and the quality of raw materials may fluctuate, requiring strict quality control.

[0011] Finally, clinical trials or literature support are needed to verify the effectiveness and safety of the formula. For example, studies have shown that lentinan can enhance immunity, ganoderma triterpenes have anti-inflammatory effects, and Hericium erinaceus polysaccharides have a protective effect on the gastric mucosa.

[0012] The bitterness or peculiar smell of edible fungi affects palatability, which needs to be addressed through flavoring or process improvements. In addition, the compatibility and interaction of different edible fungi also need to be studied to avoid adverse reactions between ingredients.

[0013] For example, the Chinese invention patent with application number 201510174273.2 discloses a medical formula food for trauma, infection, surgery and other emergency situations. According to the requirements of the "General Rules for Formula Foods for Special Medical Purposes", it combines the physical characteristics of patients with trauma, infection, surgery and other emergency situations, and rationally combines a variety of "medicine and food of the same origin" Chinese medicines according to the essence of traditional Chinese medicine. It uses a variety of Chinese medicine extracts extracted by licorice hydrolysis technology for both medicinal and edible purposes, a variety of microencapsulated probiotics, and short peptides extracted by bio-enzymatic hydrolysis, prebiotics, amino acids, carbohydrates, oils with health functions, multiple vitamins and minerals. It is made by mixing and processing. It can not only serve as a single nutrient source to meet the nutritional needs of patients with trauma, infection, surgery and other emergency situations, but also has the effect of promoting blood circulation, removing blood stasis and enhancing immunity. However, this method still has certain defects; Without the combination of active ingredients of edible fungi, the immune regulation and intestinal protection functions are insufficient, making it difficult for related health products to fully utilize the advantages of natural bioactive substances.

[0014] Therefore, we propose a method for preparing edible fungus formula food for specific medical purposes in order to solve the problems raised above. Summary of the Invention

[0015] The purpose of the present invention is to provide a method for preparing edible fungus formula food for specific medical purposes, so as to solve the problem raised in the above background technology that the active ingredients of edible fungi are not combined in the current market, the immune regulation and intestinal protection functions are insufficient, and it is difficult for related health products to fully utilize the advantages of natural bioactive substances.

[0016] To achieve the above object, the present invention provides the following technical solution: a method for preparing a formula food of edible fungi for specific medical purposes, wherein the formula food of edible fungi for specific medical purposes comprises the following raw materials in parts by weight: Edible fungus compound extract 20-30 grams, hydrolyzed whey protein 25-35 grams, medium chain triglycerides 10-20 grams, resistant dextrin 5-10 grams, oligofructose 3-8 grams, complex vitamins and minerals 0.5-2 grams, curcumin microencapsulated powder 0.1-0.5 grams, natural vanilla flavor 0.1-1 grams.

[0017] Preferably, the edible fungus composite extract comprises Lentinus edodes extract, Ganoderma lucidum extract and Hericium erinaceus extract, and the weight ratio of the three is (1-3): (1-2): (1-2).

[0018] Using the above technical solution, shiitake mushroom, ganoderma lucidum and hericium erinaceus extracts are compounded in a specific proportion to synergistically enhance the immune regulation, anti-inflammatory and intestinal mucosal repair functions.

[0019] Preferably, the complex vitamin minerals include vitamin C, zinc and selenium, and the vitamin C content in every 100g of the food for specific medical purposes is 80-120mg, the zinc content is 8-12mg, and the selenium content is 40-60μg.

[0020] By adopting the above technical solution, the combined addition of vitamin C, zinc and selenium can enhance the antioxidant capacity, promote wound healing and immune function recovery.

[0021] Preferably, the embedding wall material of the curcumin microencapsulated powder is a mixture of sodium alginate and chitosan, and the embedding rate is ≥90%.

[0022] Using the above technical solution, sodium alginate and chitosan are used to encapsulate curcumin, thereby improving its stability and intestinal targeted release efficiency and enhancing the anti-inflammatory effect.

[0023] Preferably, the food for specific medical purposes is in the form of powder with a particle size of ≤50 μm.

[0024] By adopting the above technical solution, the powder form is easy to store, prepare and tube-feed, and is suitable for people with restricted food intake.

[0025] Preferably, the hydrolysis degree of the whey protein hydrolyzate is 10-20%, and the glutamine content is ≥5%.

[0026] By adopting the above technical solution, the moderate hydrolysis of whey protein and the high glutamine content ensure rapid absorption and promote muscle synthesis.

[0027] Preferably, the proportion of medium-chain triglycerides in the fat component is ≥60%.

[0028] By adopting the above technical solution, the proportion of medium-chain triglycerides is high, which can quickly provide energy without bile emulsification and reduce the digestive burden.

[0029] Preferably, the preparation method specifically comprises the following steps: Step (1): The edible fungus raw materials are subjected to low temperature supercritical After extraction, spray drying is performed to obtain the edible fungus composite extract; Step (2): Mix the hydrolyzed whey protein, resistant dextrin, and complex vitamins and minerals, add the edible fungus complex extract and curcumin microencapsulated powder, and stir evenly; Step (3): Add medium chain triglycerides and natural vanilla flavor, and mix homogeneously at ≤25°C to prepare a powder.

[0030] Using the above technical solution, low temperature supercritical The extraction and spray drying process effectively retains the active ingredients of edible fungi and improves product stability.

[0031] Preferably, the low temperature supercritical The extraction conditions are: extraction temperature 30-45°C, pressure 15-30MPa, and extraction time 1-3h.

[0032] The above technical solution and optimized supercritical extraction conditions ensure high yield and structural integrity of edible fungi polysaccharides, triterpenes and other components.

[0033] Preferably, the inlet air temperature of the spray drying is 120-150° C., and the outlet air temperature is 60-80° C. During the homogenizing mixing process, the powdered ingredients are first added, and then the oil and flavoring are added. The mixing time is 10-20 minutes.

[0034] By adopting the above technical solution, spray drying and homogeneous mixing process control can ensure that the powder particle size is uniform, the ingredients are well dispersed, and the heat-sensitive ingredients are not degraded.

[0035] Compared with the prior art, the present invention has the following beneficial effects: the method for preparing the edible fungus formula food for specific medical purposes: 1. Triple immune regulation: Lentinan increases macrophage activity, Ganoderma lucidum reduces CRP (C-reactive protein) levels and reduces systemic inflammation, while selenium and vitamin C enhance antioxidant capacity, reducing postoperative infection rates by 15%; 2. Intestinal function repair: Hericium erinaceus β-glucan combined with oligofructose promotes the proliferation of bifidobacteria and shortens the intestinal function recovery time by 20%; 3. Efficient nutrient absorption: The absorption rate of hydrolyzed whey protein is over 90%, and the energy supply efficiency of MCT is 3 times higher than that of long-chain fatty acids, providing rapid energy supply and easy absorption. Low GI resistant dextrin + prebiotics stabilize blood sugar and promote intestinal health. 4. Palatability optimization: Natural vanilla flavor masks the bitter taste of edible fungi, increasing patient acceptance by 40%. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 Schematic diagram of the core ingredients and proportions per 100g of powder of the present invention. DETAILED DESCRIPTION

[0037] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0038] See also Figure 1The present invention provides a technical solution: a method for preparing a formula food of edible fungi for specific medical purposes, wherein the preparation of the formula food of edible fungi for specific medical purposes comprises the following raw materials in parts by weight: Edible fungus compound extract 20g, hydrolyzed whey protein 30g, medium chain triglycerides 15g, resistant dextrin 8g, oligofructose 5g, complex vitamins and minerals 1g, curcumin microencapsulated powder 0.2g, natural vanilla flavor 0.5g.

[0039] The edible fungus compound extract includes shiitake mushroom extract, ganoderma lucidum extract and hericium erinaceus extract. The weight ratio of the three is 2:1:1. Shiitake mushroom, ganoderma lucidum and hericium erinaceus extracts are compounded in a specific proportion to synergistically enhance immune regulation, anti-inflammatory and intestinal mucosal repair functions.

[0040] The complex vitamin minerals include vitamin C, zinc and selenium. Every 100g of food for specific medical purposes contains 100mg of vitamin C, 10mg of zinc and 50μg of selenium. The combined addition of vitamin C, zinc and selenium enhances antioxidant capacity, promotes wound healing and immune function recovery.

[0041] The embedding wall material of curcumin microencapsulated powder is a mixture of sodium alginate and chitosan, with an embedding rate of ≥90%. Sodium alginate and chitosan encapsulate curcumin, improving its stability and intestinal targeted release efficiency, and enhancing the anti-inflammatory effect.

[0042] Food for specific medical purposes is in the form of powder with a particle size of ≤50μm. The powder form is easy to store, prepare and tube feed, and is suitable for people with restricted food intake.

[0043] The degree of hydrolysis of hydrolyzed whey protein is 10-20%, and the glutamine content is ≥5%.

[0044] Medium-chain triglycerides account for ≥60% of the fat composition. A high proportion of medium-chain triglycerides can quickly provide energy without bile emulsification, reducing the burden of digestion.

[0045] The preparation method specifically comprises the following steps: Step (1): The edible fungus raw materials are subjected to low temperature supercritical After extraction, spray drying is performed to obtain the edible fungus composite extract; Step (2): Mix the hydrolyzed whey protein, resistant dextrin, and complex vitamins and minerals, add the edible fungus complex extract and curcumin microencapsulated powder, and stir evenly; Step (3): Add medium chain triglycerides and natural vanilla flavor, and mix homogeneously at ≤25°C to prepare a powder.

[0046] Low temperature supercritical The extraction and spray drying process effectively retains the active ingredients of edible fungi and improves product stability.

[0047] Low temperature supercritical The extraction conditions are: extraction temperature 40°C, pressure 20MPa, extraction time 2h, and optimized supercritical extraction conditions to ensure high yield and structural integrity of edible fungus polysaccharides, triterpenes and other components.

[0048] The inlet air temperature of the spray drying is 130°C and the outlet air temperature is 70°C. During the homogenous mixing process, the powdered ingredients are added first, followed by oil and flavoring. The mixing time is 15 minutes. The spray drying and homogenous mixing process are controlled to ensure that the powder particle size is uniform, the ingredients are well dispersed, and the heat-sensitive ingredients are not degraded.

[0049] Verification test: 60 postoperative patients were selected and consumed 80g of the special medical food daily for 2 weeks. The results were tested: 1. The serum prealbumin level increased by 18%, significantly higher than the 8% of the control group (traditional special medical food); 2. IL-6 inflammatory factor decreased by 22%, and intestinal flora diversity index increased by 15%; 3. Wound healing time was shortened by an average of 3.2 days, and the infection rate was reduced to 8% (compared to 20% in the control group) Functional ingredient activity verification Immune activation experiment of Lentinan The edible fungus extract (32% Lentinan content) from the experimental group was dissolved in PBS to a 100 μg / mL solution, which was then incubated with mouse macrophage RAW264.7 cells for 24 hours. The results showed that intracellular NO production increased 2.3-fold and TNF-α secretion increased 1.8-fold compared to the blank control group, demonstrating that Lentinan can enhance macrophage activity by activating the NF-κB signaling pathway.

[0050] Anti-inflammatory Experiment of Ganoderma Lucidum Triterpenoids

[0051] Using an LPS-induced acute inflammation model in rats, the experimental group was gavage-administered a solution containing Ganoderma lucidum triterpenes (5 mg / kg). Serum IL-6 levels were measured 24 hours later. Results showed that IL-6 concentrations in the experimental group decreased by 42% compared to the model group, and CRP levels decreased by 38%. There were no significant changes in liver and kidney function indicators (ALT, CREA), demonstrating the good anti-inflammatory safety of Ganoderma lucidum triterpenes.

[0052] Intestinal repair experiment of Hericium erinaceus β-glucan

[0053] A rat gastric ulcer model was established. The experimental group was fed a product containing Hericium erinaceus β-glucan (20 mg / kg). Gastric mucosal tissue sections were obtained after 7 consecutive days. Microscopic examination showed that the ulcer area in the experimental group was 65% smaller than that in the control group, and EGF receptor expression in the gastric mucosa increased 2.1-fold, demonstrating that β-glucan can accelerate mucosal repair by promoting epithelial cell proliferation.

[0054] Packaging and storage specifications

[0055] Packaging process

[0056] The product is packaged in three-layer composite film bags (PET / AL / PE). The inner PE film is treated with antistatic treatment. Nitrogen with a purity of ≥99.9% (oxygen content <0.5%) is introduced before packaging. The heat sealing temperature is 180±10°C, and the sealing edge width is 10mm. Each bag contains 40g of net weight and contains 3g of silica gel desiccant. The outer packaging box is lined with aluminum foil to prevent moisture and deterioration during transportation.

[0057] Storage condition verification

[0058] Place the packaged products in the following environments for stability testing: Accelerated test: 40℃ / 75%RH, 6 months. The test results showed that the powder had no agglomeration, the vitamin C retention rate was ≥90%, and the integrity of the curcumin microcapsules was ≥88%; Long-term test: 25℃ / 60%RH, 12 months. Microbiological indicators (total colony count <100 CFU / g, mold <10 CFU / g) meet the requirements of GB29922, and sensory evaluation (color, odor) shows no significant changes.

[0059] The contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0060] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A method for preparing a formula food of edible fungi for specific medical purposes, characterized in that: The preparation of the edible fungus formula food for specific medical purposes includes the following raw materials in parts by weight: Edible fungus compound extract 20-30 grams, hydrolyzed whey protein 25-35 grams, medium chain triglycerides 10-20 grams, resistant dextrin 5-10 grams, oligofructose 3-8 grams, complex vitamins and minerals 0.5-2 grams, curcumin microencapsulated powder 0.1-0.5 grams, natural vanilla flavor 0.1-1 grams.

2. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The edible fungus composite extract comprises shiitake mushroom extract, ganoderma lucidum extract and hericium erinaceus extract, and the weight ratio of the three is (1-3): (1-2): (1-2).

3. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The complex vitamin mineral comprises vitamin C, zinc and selenium. The content of vitamin C in every 100g of the food for specific medical purposes is 80-120mg, the content of zinc is 8-12mg and the content of selenium is 40-60μg.

4. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, wherein: The embedding wall material of the curcumin microencapsulated powder is a mixture of sodium alginate and chitosan, and the embedding rate is ≥90%.

5. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The food for specific medical purposes is in the form of powder with a particle size of ≤50 μm.

6. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The hydrolysis degree of the hydrolyzed whey protein is 10-20%, and the glutamine content is ≥5%.

7. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The medium-chain triglycerides account for ≥60% of the fat component.

8. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 1, characterized in that: The preparation method specifically comprises the following steps: Step (1): The edible fungus raw materials are subjected to low temperature supercritical After extraction, spray drying is performed to obtain the edible fungus composite extract; Step (2): Mix the hydrolyzed whey protein, resistant dextrin, and complex vitamins and minerals, add the edible fungus complex extract and curcumin microencapsulated powder, and stir evenly; Step (3): add medium chain triglycerides and natural vanilla flavor, and mix homogeneously at ≤25°C to prepare a powder.

9. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 8, characterized in that: The low temperature supercritical The extraction conditions are: extraction temperature 30-45°C, pressure 15-30MPa, and extraction time 1-3h.

10. The method for preparing a formula food of edible fungi for specific medical purposes according to claim 8, characterized in that: The inlet air temperature of the spray drying is 120-150° C., and the outlet air temperature is 60-80° C. During the homogenizing mixing process, the powdered ingredients are first added, and then the oil and flavoring are added. The mixing time is 10-20 minutes.

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