Nanometer iron oxide composition and application thereof in improving iron-deficiency fatigue

Abstract

The invention discloses a nano iron oxide composition and application thereof in improvement of iron-deficiency fatigue, and the composition comprises the following components in parts by mass: 0.5-5 parts of nano iron oxide; 2-10 parts of ascorbic acid; 5-15 parts of small molecule peptide; 5 to 15 parts of oligosaccharide; 10 to 30 parts of gelatin; the particle size of the nano iron oxide is 3-10nm, and the surface of the nano iron oxide is coated with sodium citrate or chitosan. Fe < 3 + > is reduced into Fe < 2 + > which is easy to absorb through ascorbic acid, the small molecule peptide promotes iron transport, the oligosaccharide prolongs the residence time of intestinal tracts, and the gelatin and other carriers improve the taste, so that a multi-mechanism synergistic interaction system is formed; the hemoglobin level can be increased by 28% and is obviously superior to 12% of a traditional iron agent, and side effects such as gastrointestinal irritation are avoided; the product can be prepared into various dosage forms such as soft sweets, decoction pieces and the like, has the advantages of high absorptivity, good safety, strong palatability and the like, and is suitable for nutrition intervention of iron-deficiency fatigue crowds such as women, old people and the like; the raw materials are easy to obtain, the process is simple, and the industrial prospect is good.

Description

Technical Field

[0001] The present invention relates to the technical field of food and nanomaterials, and in particular to a nano iron oxide composition and application thereof in improving iron deficiency fatigue. Background Art

[0002] Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies worldwide, especially among women, children, the elderly, and athletes. Iron is an essential component for hemoglobin synthesis. Long-term iron deficiency not only leads to fatigue and decreased immunity, but may also affect cognitive function. Currently, iron supplements mainly include inorganic iron (such as ferrous sulfate and ferrous fumarate) and organic iron (such as heme iron and polysaccharide iron complexes), but these traditional iron supplements still have significant defects in practical applications.

[0003] Low absorption rates and significant gastrointestinal irritation. While inexpensive, inorganic iron supplements such as ferrous sulfate typically have a bioavailability of less than 10% and easily combine with phytic acid and polyphenols in food to form insoluble precipitates, further reducing absorption. Furthermore, free iron ions are highly irritating to the gastrointestinal mucosa, often causing side effects such as nausea, abdominal pain, and constipation, leading to poor patient compliance.

[0004] The potential and bottleneck of nano-iron oxide. Nano-iron oxide is considered to be a promising iron supplement due to its high specific surface area and controlled release properties. However, when used alone, it still faces the following problems: insufficient intestinal solubility: nanoparticles tend to aggregate in the alkaline environment of the intestine, reducing the release efficiency of iron ions; limited bioavailability: trivalent iron (Fe 3+ ) needs to be converted into divalent iron (Fe 2+ ) to be absorbed, but it lacks an efficient reduction system; poor stability: uncoated nanoparticles may be destroyed by gastric acid or interact with food ingredients. The lack of complex functional products. Currently, iron supplements on the market mostly focus on a single iron source, lacking a comprehensive solution to enhance absorption rate, improve safety and palatability through the synergistic effect of multiple components. For example: no combination of reducing agents such as vitamin C to promote iron conversion; lack of carriers such as small molecule peptides to enhance iron transport; neglect of the regulation of intestinal retention time by ingredients such as oligosaccharides; single dosage form design (such as tablets, capsules), which makes it difficult to meet the taste needs of children, the elderly and other groups.

[0005] Therefore, in response to the above problems, the present invention provides a nano-iron oxide composition and its application in improving iron deficiency fatigue, and develops a composite nutritional composition that solves the defects of traditional iron preparations through the synergistic action of multiple mechanisms to improve iron absorption efficiency, reduce irritation, and adapt to diversified dosage forms. Summary of the Invention

[0006] The purpose of the present invention is to provide a nano iron oxide composition and its application in improving iron deficiency fatigue, so as to improve the absorption efficiency of iron, reduce irritation and adapt to diversified dosage forms.

[0007] The purpose of the present invention is achieved through the following technical solutions:

[0008] A nano iron oxide composition, comprising the following components in parts by mass:

[0009] 0.5-5 parts of nano iron oxide;

[0010] 2-10 parts of ascorbic acid;

[0011] 5-15 parts of small molecule peptide;

[0012] 5-15 parts of oligosaccharides;

[0013] 10-30 parts of gelatin;

[0014] The balance is purified water and natural flavors.

[0015] Preferably, the particle size of the nano iron oxide is 3 to 10 nm, and the surface is coated with sodium citrate or chitosan.

[0016] Preferably, the small molecule peptide is selected from one or more of corn oligopeptides, soybean peptides or whey peptides.

[0017] Preferably, the oligosaccharide is selected from one or more of fructooligosaccharides, galacto-oligosaccharides or isomaltooligosaccharides.

[0018] Preferably, the composition is in the form of soft candy, decoction pieces, oral liquid or chewable tablet.

[0019] The present application also claims a method for preparing the nano-iron oxide composition, comprising the following steps:

[0020] (1) Mixing nano-iron oxide, ascorbic acid, small molecule peptide and oligosaccharide uniformly;

[0021] (2) Add gelatin and purified water, heat to 60-80°C and stir to dissolve;

[0022] (3) Cool to 40-50°C and add natural flavors for seasoning;

[0023] (4) Pour into a mold for molding or spray dry and granulate to obtain the target dosage form.

[0024] Preferably, the molding method includes soft candy pouring and cooling, tableting or freeze-drying granulation.

[0025] The present application also claims protection for the use of the nano-iron oxide composition in the preparation of functional foods or nutritional supplements for improving iron deficiency fatigue.

[0026] Preferably, the functional food comprises soft candy, oral liquid or solid powder.

[0027] Due to the application of the above technical solution, the present invention has the following beneficial effects compared with the prior art:

[0028] 1. In terms of technical performance, the present invention's composition achieves a significant improvement in iron absorption efficiency through the synergistic action of multiple components. Nano-iron oxide provides an iron source with a high specific surface area, vitamin C acts as a highly efficient reducing agent to promote the conversion of trivalent iron to divalent iron, small molecule peptides enhance the intestinal transport capacity of iron ions, and oligosaccharides prolong the composition's retention time in the intestine. This multi-mechanism synergistic action increases the iron absorption rate by more than 2 times compared to traditional iron supplements. Caco-2 cell model and animal experimental data confirm that the bioavailability of the composition is significantly superior to conventional iron supplements such as ferrous sulfate.

[0029] 2. The present invention has outstanding advantages in terms of safety. Through the application of nano-coating technology and sustained-release matrix, the composition effectively reduces the direct irritation of free iron ions to the gastrointestinal tract, avoiding the common side effects of traditional iron supplements such as nausea and abdominal pain. At the same time, strict raw material screening and preparation process control ensure that the product is free of heavy metal residues, making it suitable for long-term safe use by all types of people.

[0030] 3. The present invention's composition exhibits significant advantages in terms of product palatability and dosage form diversity. By adding natural flavors and using food-grade carriers such as gelatin, the product's taste is greatly improved, making it more acceptable to special groups such as children and the elderly. The flexible formulation design enables it to be processed into various dosage forms such as soft candies, nutritional bars, and oral decoction pieces to meet the preferences and usage scenarios of different consumers.

[0031] 4. In terms of market application, the composition of the present invention has wide applicability. Its mild properties make it suitable for special groups prone to iron deficiency symptoms, such as women, the elderly, teenagers, and athletes. At the same time, because it uses food-grade raw materials and has a simple preparation process, the product has good industrial prospects and is easy to achieve large-scale production and commercial promotion.

[0032] 5. From the perspective of social benefits, the promotion and application of this product will help improve the global health problem of iron deficiency anemia, especially providing a new solution for patients who are intolerant to traditional iron supplements; its good taste and diverse dosage form design will also help improve patients' medication compliance, thereby better achieving nutritional intervention effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the specific embodiments or the description of the prior art. Obviously, some of the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be made based on these drawings without paying any creative work.

[0034] Figure 1 This is a graph showing the iron ion release curve in simulated gastric and intestinal fluids according to Example 1 of the present invention;

[0035] Figure 2 This is a comparison chart of the Hb increase of animals in Example 1, Comparative Example 4, and Comparative Example 5 of the present invention. DETAILED DESCRIPTION

[0036] In order to have a clearer understanding of the technical features, purposes and effects of the present invention, a specific implementation scheme is now described in detail.

[0037] The present invention is further described below with reference to the following examples, but the present invention is not limited to the following examples. The implementation conditions used in the examples can be further adjusted according to the different requirements of specific applications. The implementation conditions not specified are conventional conditions in the industry. The technical features involved in the various embodiments of the present invention may be combined with each other as long as they do not conflict with each other.

[0038] Example 1

[0039] See attached Figure 1 And attached Figure 2 This embodiment provides a nano-iron oxide composition, which comprises the following components in parts by mass:

[0040] 2 parts of nano iron oxide;

[0041] 4 parts of ascorbic acid;

[0042] 10 parts of corn oligopeptides;

[0043] 8 parts of oligofructose;

[0044] 20 parts gelatin;

[0045] The balance is purified water and natural flavors;

[0046] The particle size of the nano iron oxide is 4.5 nm, and the surface is coated with sodium citrate;

[0047] The composition is in the form of soft candy, decoction pieces, oral liquid or chewable tablet.

[0048] The preparation method of the nano iron oxide composition comprises the following steps:

[0049] (1) Mixing nano-iron oxide, ascorbic acid, small molecule peptide and oligosaccharide uniformly;

[0050] (2) Add gelatin and purified water, heat to 70°C and stir to dissolve;

[0051] (3) Cool to 45°C and add natural flavoring;

[0052] (4) Pour into a mold for molding or spray dry and granulate to obtain the target dosage form.

[0053] The molding method includes soft candy pouring and cooling, tableting or freeze-drying granulation.

[0054] The nano-iron oxide composition is used in the preparation of functional foods or nutritional supplements for improving iron deficiency fatigue. The functional foods include soft candies, oral liquids or solid granules.

[0055] Comparative Example 1

[0056] This comparative example is carried out on the basis of the above-mentioned Example 1, and the similarities with the above-mentioned Example 1 are not repeated here.

[0057] In this comparative example, no ascorbic acid (VC) was added.

[0058] Comparative Example 2

[0059] This comparative example is carried out on the basis of the above-mentioned Example 1, and the similarities with the above-mentioned Example 1 are not repeated here.

[0060] In this comparative example, no corn oligopeptide was added.

[0061] Comparative Example 3

[0062] This comparative example is carried out on the basis of the above-mentioned Example 1, and the similarities with the above-mentioned Example 1 are not repeated here.

[0063] In this comparative example, no fructooligosaccharide was added.

[0064] Comparative Example 4

[0065] See attached Figure 2 This comparative example is carried out on the basis of the above-mentioned Example 1, and the similarities with the above-mentioned Example 1 are not repeated here.

[0066] In this comparative example, nano-iron oxide was replaced by FeSO4.

[0067] Comparative Example 5

[0068] See attached Figure 2 This comparative example is carried out on the basis of the above-mentioned Example 1, and the similarities with the above-mentioned Example 1 are not repeated here.

[0069] In this comparative example, no iron agent was added.

[0070] Comparative Example 6

[0071] This comparative example was prepared by physical mixing.

[0072] The above examples and comparative examples were subjected to Caco-2 cell permeability test and SD rats were orally administered the soft candy once daily for 12 consecutive weeks to test the increase in hemoglobin (Hb). The test results are shown in Table 1.

[0073] Table 1

[0074]

[0075] The iron release rate in simulated gastric fluid was tested for the above examples and comparative examples. The test results are shown in Table 2.

[0076] Table 2

[0077]

[0078] The iron release rate in simulated intestinal fluid was tested for the above examples and comparative examples. The test results are shown in Table 3.

[0079] Table 3

[0080]

[0081] As can be seen from the above table, after SD rats took the soft candy orally once a day for 12 consecutive weeks, their hemoglobin (Hb) increased by 28%; the control FeSO4 group increased by 12%, which was a significant comparison; the iron transport efficiency of the composition of the present invention was about 1.8 times higher than that of single nano-iron oxide, confirming the synergistic contribution of vitamin C (reducing effect), small molecule peptides (transport promotion) and oligosaccharides (prolonged retention); the rats in Example 1 of the present invention did not develop diarrhea or ulcers, while the incidence rate in the FeSO4 group was about 15%, indicating that the present invention does not cause gastrointestinal irritation.

[0082] In summary, in terms of technical performance, the present invention achieves a significant improvement in iron absorption efficiency through the synergistic effect of multiple components. Nano-iron oxide provides an iron source with a high specific surface area, vitamin C acts as an efficient reducing agent to promote the conversion of trivalent iron to divalent iron, small molecule peptides enhance the intestinal transport capacity of iron ions, and oligosaccharides prolong the retention time of the composition in the intestine. This multi-mechanism synergistic effect increases the iron absorption rate by more than 2 times compared with traditional iron preparations; both Caco-2 cell model and animal experimental data confirm that the bioavailability of the composition is significantly better than conventional iron preparations such as ferrous sulfate; in terms of safety, the present invention has outstanding advantages. Through the application of nano-coating technology and sustained-release matrix, the direct stimulation of free iron ions on the gastrointestinal tract is effectively reduced, and the common side effects of traditional iron preparations such as nausea and abdominal pain are avoided; at the same time, strict raw material screening and preparation process control ensure that the product has no heavy metal residues and is suitable for long-term safe use by all kinds of people; in terms of product palatability and dosage form diversity, the present invention exhibits The invention shows significant advantages. By adding natural flavors and using food-grade carriers such as gelatin, the taste of the product is greatly improved, making it easier for special groups such as children and the elderly to accept; the flexible formula design allows it to be processed into a variety of dosage forms such as soft candies, nutrition bars, oral decoction pieces, etc., to meet the preferences and usage scenarios of different consumers; in terms of market application, the composition of the present invention has a wide range of applicability, and its mild properties make it suitable for special groups such as women, the elderly, teenagers and athletes who are prone to iron deficiency symptoms; at the same time, since food-grade raw materials are used and the preparation process is simple, the product has good industrialization prospects and is easy to achieve large-scale production and commercial promotion; from the perspective of social benefits, the promotion and application of the product will help to improve the global health problem of iron deficiency anemia, especially provide a new solution for patients who are intolerant to traditional iron preparations; its good taste and diverse dosage form design also help to improve patients' medication compliance, thereby better achieving nutritional intervention effects.

[0083] The above-described embodiment merely represents one embodiment of the present invention. While the description is relatively specific and detailed, it should not be construed as limiting the scope of the patent. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the spirit of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the patent for this invention shall be determined by the appended claims.

Claims

1. A nano iron oxide composition, characterized in that: Calculated by mass, it includes the following components: 0.5-5 parts of nano iron oxide; 2-10 parts of ascorbic acid; 5-15 parts of small molecule peptide; 5-15 parts of oligosaccharides; 10-30 parts of gelatin; The balance is purified water and natural flavors.

2. The nano-iron oxide composition according to claim 1, characterized in that The particle size of the nano iron oxide is 3-10 nm, and the surface is coated with sodium citrate or chitosan.

3. The nano-iron oxide composition according to claim 1, characterized in that The small molecule peptide is selected from one or more of corn oligopeptides, soybean peptides or whey peptides.

4. The nano-iron oxide composition according to claim 1, characterized in that The oligosaccharide is selected from one or more of fructooligosaccharides, galacto-oligosaccharides or isomaltooligosaccharides.

5. The nano iron oxide composition according to claim 1, characterized in that The composition is in the form of soft candy, decoction pieces, oral liquid or chewable tablet.

6. A method for preparing the nano-iron oxide composition according to any one of claims 1 to 5, characterized in that: The steps include: (1) Mixing nano-iron oxide, ascorbic acid, small molecule peptide and oligosaccharide uniformly; (2) Add gelatin and purified water, heat to 60-80°C and stir to dissolve; (3) Cool to 40-50°C and add natural flavors for seasoning; (4) Pour into a mold for molding or spray dry and granulate to obtain the target dosage form.

7. The method for preparing the nano-iron oxide composition according to claim 6, wherein: The molding method includes soft candy pouring and cooling, tableting or freeze-drying granulation.

8. Use of the nano-iron oxide composition according to any one of claims 1 to 5 in the preparation of functional foods or nutritional supplements for improving iron deficiency fatigue.

9. Use of the nano-iron oxide composition according to claim 8 in preparing a functional food or nutritional supplement for improving iron deficiency fatigue, characterized in that: The functional food includes soft candy, oral liquid or solid powder.

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