Traditional Chinese medicine heart nourishing and mind tranquilizing formula for treating insomnia

Abstract

The invention discloses a traditional Chinese medicine heart nourishing and nerve soothing formula for treating insomnia. The formula is composed of spina date seed, mulberry, dendrobium, trichosanthes peel, cassia seed, dark plum, poria with hostwood and green plum blossom. The heart-nourishing and mind-tranquilizing formula is mainly used for nourishing the heart, tranquilizing the mind, nourishing yin, clearing heat, soothing the liver and relieving depression, and spina date seeds and poria with hostwood in the formula are used as monarch materials to nourish heart yin, tranquilize the mind, stabilize the mind and Mulberry, dendrobium and dark plum are used as ministerial drugs to nourish yin, promote salivation, clear deficiency heat and improve dysphoria, night sweat and dry mouth caused by fire excess from yin deficiency. The semen cassiae has the effects of clearing liver fire and relaxing bowel, and the semen cassiae and the semen cassiae can assist in clearing away the heart-fire and reducing phlegm; the green plum blossom can soothe liver depression without hurting yin, and is capable of soothing liver, harmonizing stomach and regulating qi. The prescription is used for overall conditioning of complex pathogenesis (yin deficiency, liver depression and phlegm heat) of insomnia, and is especially suitable for people with insomnia caused by high pressure, unsmooth emotion and staying up late at present. Compatible medication has local characteristics of new-safety medicine, is particularly beneficial to improvement of insomnia symptoms and the like, and is definite in curative effect and free of toxic and side effects.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine heart-nourishing and mind-calming prescription for treating insomnia. Background Art

[0002] Insomnia refers to the subjective experience of being dissatisfied with sleep duration and / or quality, which impacts daytime social functioning, despite having appropriate sleep opportunities and a suitable sleep environment. Insomnia manifests as difficulty falling asleep, maintaining sleep, early awakenings, decreased sleep quality, and reduced total sleep time, accompanied by daytime dysfunction.

[0003] Insomnia not only reduces the patient's quality of life, but may also increase other health risks such as cardiovascular and cerebrovascular diseases, metabolic diseases, anxiety and depression. The treatment drugs recommended by current clinical guidelines mainly include benzodiazepines Receptor agonists, sedative antidepressants, dual orexin receptor antagonists, and melatonin receptor agonists are among the most commonly used. Estazolam and zopiclone are the most commonly used. Due to potential adverse reactions and diminished efficacy with long-term medication use, many patients seek treatment with Traditional Chinese Medicine (TCM). Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine formula for treating insomnia. The formula is prepared according to the principle of monarch, minister, assistant and envoy. The formula mainly nourishes the heart and calms the mind, and is combined with yin-nourishing and heat-clearing herbs and liver-soothing and qi-regulating herbs based on syndrome differentiation and treatment. It comprehensively regulates the complex pathogenesis of insomnia (yin deficiency, liver depression, and phlegm-heat). The formula is particularly suitable for people suffering from insomnia caused by stress, emotional distress, and staying up late. It nourishes yin, clears heat, resolves phlegm, and regulates qi, treating both the symptoms and the root cause, and can achieve good clinical results.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] A traditional Chinese medicine prescription for nourishing the heart and calming the mind for treating insomnia is prepared from the following traditional Chinese medicine raw materials by weight:

[0007] Ziziphus jujuba seeds 15-25g, Trichosanthes peel 15-25g, mulberry 5-15g, cassia seed 5-15g, black plum 7-9g, dendrobium 5-15g, poria 10-20g, green plum blossom 10-15g.

[0008] The explanation of each Chinese medicine in this prescription is as follows:

[0009] Suanzaorensis seeds

[0010] [Nature and flavor and meridians] Sweet, sour, neutral. Enters the Liver, Gallbladder, and Heart meridians.

[0011]

Function

[0012] [Application] Treats insomnia, palpitations, spontaneous sweating and night sweats due to physical weakness.

[0013]

Modern Pharmacology

[0014] mulberries

[0015] [Nature and flavor and meridians] Sweet, sour, cold; enters the heart, liver and kidney meridians.

[0016]

Function

[0017] [Application] Treats dizziness and tinnitus, palpitations and insomnia, premature graying of hair, thirst due to loss of body fluid, internal heat and thirst, and constipation due to blood deficiency.

[0018]

Modern Pharmacology

[0019] Dendrobium

[0020] [Nature and Flavor and Meridians] Sweet, slightly cold. Enters the Stomach and Kidney meridians.

[0021]

Function

[0022] [Application] It is used for yin damage and body fluid deficiency, dry mouth and thirst, poor appetite and retching, fever after illness, and blurred vision.

[0023]

Modern Pharmacology

[0024] Trichosanthes peel

[0025] [Nature and flavor and meridians] Sweet, cold. Enters the lung and stomach meridians.

[0026]

Function

[0027] [Application] Treats cough due to phlegm-heat, chest tightness and side pain.

[0028]

Modern Pharmacology

[0029] Cassia seeds

[0030] [Nature and Flavor and Meridians] Sweet, bitter, salty, slightly cold. Enters the Liver and Large Intestine meridians.

[0031]

Function

[0032] [Application] Treats red and painful eyes, photophobia and excessive tearing, headache and dizziness, blurred vision and constipation.

[0033]

Modern Pharmacology

[0034] Black plum

[0035] [Nature and flavor and meridians] Sour, astringent, neutral. Enters the liver, spleen, lung and large intestine meridians.

[0036]

Function

[0037] [Application] Treats chronic cough due to lung deficiency, chronic dysentery and loose bowels, deficiency-heat and thirst, ascariasis, vomiting and abdominal pain, and biliary ascariasis.

[0038]

Modern Pharmacology

[0039] Poria

[0040] [Nature and flavor and meridians] Sweet, neutral. Enters the heart and spleen meridians.

[0041]

Function

[0042] [Application] Used to treat palpitations due to weak heart, forgetfulness, insomnia, epilepsy, and difficulty urinating.

[0043]

Modern Pharmacology

[0044] Green plum blossoms

[0045] [Nature and flavor and meridians] Bitter, slightly sweet, neutral. Enters the Liver and Stomach meridians.

[0046]

Function

[0047] [Application] Treats chest and flank pain, stomachache, indigestion, and neurasthenia.

[0048]

Modern Pharmacology

[0049] The Chinese medicine compatibility principle of the present invention is:

[0050] In this formula, Ziziphus jujuba seeds and Poria cocos act as the main ingredients, nourishing heart yin, calming the mind, and alleviating restlessness. Mulberry, Dendrobium, and Prunus mume serve as the auxiliary ingredients, nourishing yin and promoting fluid production, clearing away heat, and alleviating irritability, night sweats, and dry mouth caused by yin deficiency and excessive fire. Trichosanthes root bark, with its sweet and cold properties, relieves chest congestion, clears phlegm, and relieves stagnation. Cassia seed clears the liver, purges heat, and moistens the intestines, promoting bowel movements. Together, they assist in clearing the heart and resolving phlegm. Green plum blossoms soothe liver stagnation without damaging yin, lightly clearing the liver, harmonizing the stomach, and regulating qi. This formula is light and agile, combining medicinal and edible elements. It nourishes without stagnating, nourishes without being greasy, and addresses both the symptoms and the root cause, achieving excellent clinical results.

[0051] As a preferred technical solution of the present invention, the traditional Chinese medicine for nourishing the heart and calming the mind is prepared from the following traditional Chinese medicine raw materials by weight:

[0052] 20g of Chinese jujube seeds, 20g of Trichosanthes peel, 10g of mulberry, 10g of cassia seed, 8g of black plum, 10g of dendrobium, 15g of poria, and 12g of green plum blossom.

[0053] Take 1 portion of each Chinese medicinal material in the formula and add it to a casserole. Add water and soak for 40 minutes. The amount of water exceeds 2 cm on the surface of the medicinal material. After boiling over high heat, simmer for 30 minutes over low heat. Filter out the medicinal liquid for later use. Add purified water over 2 cm on the surface of the medicinal material. After boiling over high heat, simmer for 20 minutes over low heat. Filter out the medicinal liquid and mix it with the previous medicinal liquid to obtain 150-250 ml of the medicinal liquid. Divide it into 2 portions and take 1 portion each at noon and before going to bed. The present invention has been clinically verified to be able to be used to treat insomnia and has a good therapeutic effect.

[0054] The traditional Chinese medicine formula for nourishing the heart and calming the mind, proposed in the present invention, is composed of Chinese medicinal herbs including jujube seeds, Trichosanthes root bark, mulberry, cassia seed, black plum, dendrobium, poria, and green plum blossom. This formula, with its combination of herbs, exhibits local characteristics of Xin'an medicine and is particularly beneficial in alleviating insomnia symptoms, with proven efficacy and no toxic side effects. DETAILED DESCRIPTION

[0055] The present invention is further described in detail below with reference to the embodiments.

[0056] Example 1

[0057] Preparation of Yangxin Anshen Recipe:

[0058] Compound composition: 20g of Chinese jujube seeds, 20g of Trichosanthes peel, 10g of mulberry, 10g of cassia seed, 8g of black plum, 10g of dendrobium, 15g of poria, and 12g of green plum blossom.

[0059] Take 1 portion of each Chinese medicinal material in the formula and add it to a casserole. Add water and soak for 40 minutes. The water level should exceed the surface of the medicinal materials by 2 cm. Boil over high heat and then simmer over low heat for 30 minutes. Filter out the medicinal liquid for later use. Add purified water to exceed the surface of the medicinal materials by 2 cm. Boil over high heat and then simmer over low heat for 20 minutes. Filter out the medicinal liquid and mix it with the previous liquid to obtain about 200 ml of medicinal liquid. Divide it into 2 portions and take 1 portion each at noon and before going to bed.

[0060] Example 2

[0061] The present invention included 10 patients diagnosed with insomnia from 2024 to 2025 at the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine (case information is shown in Table 4). They received the Yangxin Anshen prescription (prepared according to the method of Example 1) twice daily for a course of 14 times, for a total of 2 weeks. The changes in the Athens Insomnia Rating score, Insomnia Severity Index, and Insomnia Heart-Kidney Disharmony TCM Syndrome Score before and after treatment with the prescription were studied to observe the efficacy.

[0062] 1. The Athens Insomnia Scale (AIS) uses a subjective assessment method, requiring participants to rate each item based on their individual situation. The scores for all items are then summed to obtain a total score. Based on the total score, insomnia can be categorized as no insomnia, suspected insomnia, insomnia symptoms, or insomnia grade. Scores of 0-4 indicate no insomnia, 5-7 indicate suspected insomnia, 8-12 indicate insomnia symptoms, and 13-24 indicate insomnia grade. This scale has high reliability and validity and can be used to assess the severity of insomnia symptoms and treatment effectiveness.

[0063] The specific steps are:

[0064] (1) Explain the principles of AIS to the patient and provide each patient with the same test information. The patient should carefully read and sign the informed consent form. It is suitable for people who have had sleep problems at least three times a week in the past month. The scale assesses sleep conditions in the past month. The subjects need to choose the answer option that best suits their situation based on their actual situation.

[0065] (2) After the test-taker has finished answering the questions, the medical staff or trained personnel will calculate the score, record it, and inform the test-taker of the result.

[0066] Table 1 Athens Insomnia Scale (AIS)

[0067] If the following problems occur 3 times a week, an evaluation is required.

[0068] Name: Gender: Age: Hospital Number: Assessment Time:

[0069]

[0070] Scoring criteria: 0-4 points: no insomnia problem; 5-15 points: mild to moderate insomnia may exist; 16-24 points: severe insomnia, requiring clinical intervention.

[0071] 2. The Insomnia Severity Index (ISI) uses a subjective assessment method, requiring participants to rate each item based on their own situation, and finally adding up the scores of all items to obtain a total score. Based on the total score of the scale, insomnia can be divided into no significant insomnia problem, mild insomnia, moderate insomnia, and severe insomnia levels. Among them, 0-7 points: no significant insomnia problem; 8-14 points: mild insomnia; 15-21 points: moderate insomnia; 22-28 points: severe insomnia. This scale has high reliability and validity and can be used to assess the severity of insomnia symptoms and the effectiveness of treatment.

[0072] The specific steps are:

[0073] (1) Explain the principles of ISI to the patient and provide each patient with the same test information. The patient should carefully read and sign the informed consent form. This form is applicable to patients with various types of insomnia. The subject should choose the answer option that best suits their situation based on their actual situation.

[0074] (2) After the test-taker has finished answering the questions, the medical staff or trained personnel will calculate the score, record it, and inform the test-taker of the result.

[0075] Table 2 ISI Insomnia Severity Index Scale

[0076]

[0077] Severity rating: 0-7 points: no significant insomnia problem; 8-14 points: mild insomnia; 15-21 points: moderate insomnia; 22-28 points: severe insomnia.

[0078] 3. The Traditional Chinese Medicine (TCM) Insomnia Symptom Score Scale for Heart-Kidney Disharmony uses peer assessment, requiring professionals to score each item based on the individual's condition. The total score is then summed to obtain a total score. Insomnia can be categorized as mild, moderate, or severe based on the total score. Mild: Primary and secondary symptoms combined score 3-6 points, with tongue and pulse generally consistent; Moderate: Primary and secondary symptoms combined score 7-12 points, with typical tongue and pulse; Severe: Primary and secondary symptoms combined score ≥13 points, with significant tongue and pulse abnormalities. This scale has high reliability and validity and can be used to assess the severity of insomnia symptoms and treatment effectiveness.

[0079] The specific steps are:

[0080] (1) Explain the principle of the TCM syndrome scoring table for insomnia caused by disharmony between the heart and kidneys to the patient, provide each patient with the same test information, and the patient should carefully read and sign the informed consent form. This table is applicable to patients with insomnia caused by disharmony between the heart and kidneys. Professionals should select the answer option that best suits the subject's condition based on the subject's actual needs.

[0081] (2) After the test-taker has finished answering the questions, the medical staff or trained personnel will calculate the score, record it, and inform the test-taker of the result.

[0082] Table 3 TCM syndrome score table for insomnia, Yin deficiency, liver depression and phlegm disturbance

[0083]

[0084] Diagnostic criteria: main symptom (insomnia) score ≥ 1 point; secondary symptom score ≥ 2 items and total score ≥ 6 points; tongue and pulse meet the characteristics of heart-kidney disharmony (red tongue with little coating + thin and rapid pulse).

[0085] Syndrome grading: Mild: the main symptom + secondary symptom score is 3-6 points, and the tongue and pulse are basically consistent; Moderate: the main symptom + secondary symptom score is 7-12 points, and the tongue and pulse are typical; Severe: the main symptom + secondary symptom score is ≥13 points, and the tongue and pulse are significantly abnormal.

[0086] 4. Statistical results

[0087] Table 4 Case information and statistical results before and after treatment

[0088]

[0089] Comparison in Table 4 shows that after treatment, the AIS, ISI, and TCM syndrome score of insomnia patients decreased compared to those before treatment (P < 0.05), respectively (P < 0.05). Therefore, the present invention provides an effective therapeutic drug for the clinical treatment of insomnia, a difficult-to-treat disease, and has broad prospects for clinical application.

[0090] The above content is merely an example and explanation of the concept of the present invention. Those skilled in the art may make various modifications or additions to the described specific embodiments or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine prescription for nourishing the heart and calming the mind for treating insomnia, characterized in that: Prepared from the following weight of Chinese medicinal raw materials: Ziziphus jujuba seeds 15-25g, Trichosanthes peel 15-25g, mulberry 5-15g, cassia seed 5-15g, black plum 7-9g, dendrobium 5-15g, poria 10-20g, green plum blossom 10-15g.

2. The traditional Chinese medicine for nourishing the heart and calming the mind according to claim 1, characterized in that: Prepared from the following weight of Chinese medicinal raw materials: 20g of Chinese jujube seeds, 20g of Trichosanthes peel, 10g of mulberry, 10g of cassia seed, 8g of black plum, 10g of dendrobium, 15g of poria, and 12g of green plum blossom.

3. The traditional Chinese medicine for nourishing the heart and calming the mind according to claim 1 or 2, characterized in that: Take 1 portion of each Chinese medicinal material in the formula and add it to a casserole. Add water and soak for 40 minutes. The water level should exceed the surface of the medicinal materials by 2 cm. Boil over high heat and then simmer over low heat for 30 minutes. Filter out the medicinal liquid for later use. Add purified water to exceed the surface of the medicinal materials by 2 cm. Boil over high heat and then simmer over low heat for 20 minutes. Filter out the medicinal liquid and mix it with the previous liquid to obtain 150-250 ml of medicinal liquid. Divide it into 2 portions and take 1 portion each at noon and before going to bed.

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