Preparation method of composition with fat reducing effect

Abstract

The invention relates to a preparation method of a composition with a fat reducing effect. The preparation process method of the composition of the exocarpium citri rubrum, the white kidney bean powder, the folium mori, the fried hawthorn fruits, the lotus leaves, the semen raphani, the semen coicis, the semen cassiae and the passionflower powder comprises the following steps: preparing flavone in the exocarpium citri rubrum, preparing total flavone in the fried hawthorn fruits, preparing an alpha-amylase inhibitor in the white kidney bean powder, preparing folium mori powder and lotus leaf powder, preparing semen raphani, semen cassiae and semen coicis extracts, and preparing the composition of the exocarpium citri rubrum, the folium mori, the semen cassiae and the passionflower powder. A solvent extraction method, a cloud point extraction method and a microwave-assisted extraction method are creatively used for respectively extracting an alpha-amylase inhibitor, flavone, general flavone and the like in the preparation process of the concentrated composition with the fat reducing effect, the secondarily concentrated composition and the composition with the fat reducing effect, and the method has the advantages of being innovative in flow process, high in extraction efficiency, high in extract quality and the like.

Description

Technical Field

[0001] The invention relates to a method for preparing a composition with fat-reducing effect, belonging to the technical field of regulating phlegm-damp constitution. Background Art

[0002] Studies have found that a phlegm-damp constitution is closely associated with metabolic diseases such as obesity, diabetes, hyperlipidemia, cardiovascular disease, and chronic respiratory diseases. Existing research has found that among the associated drug combinations used in this study, the combination of Poria cocos, Atractylodes macrocephala, Pinellia ternata, and Tangerine peel encompasses most of the association rules found in the literature mining structure for the differentiation and treatment of phlegm-damp constitution. However, the present invention innovatively utilizes tangerine peel, white kidney bean powder, stir-fried hawthorn, and lotus leaves to create a low-calorie, high-satisfaction combination product with a significant effect on regulating phlegm-damp constitution.

[0003] Tangerine peel not only has a refreshing aroma that is often used by ordinary people to remove odors and freshen the air, but it also possesses exceptional medicinal value, being a miraculous remedy. Its warm nature, pungent and bitter flavors, and its entry into the lung and spleen meridians, dispel cold and dampness, regulate qi and resolve phlegm, and soothe the stomach and strengthen the spleen. It is used to treat chest distension and fullness caused by spleen and stomach qi stagnation, as well as chest tightness, shortness of breath, and excessive phlegm caused by food stagnation, alcohol consumption, and phlegm-dampness blocking the lungs.

[0004] Studies have shown that white kidney beans have multiple health benefits, including lowering blood lipids, losing weight, lowering blood sugar, and regulating intestinal flora. The benefits mainly come from α-amylase inhibitors, which are complex glycoproteins with strong enzyme inhibition activity and high safety. Taking appropriate doses before meals can inhibit the absorption and conversion of starch, thereby achieving blood sugar control and weight loss. It has broad application and development prospects.

[0005] Lotus leaf extract is rich in alkaloids, which are considered the main bioactive substances in lotus leaf for lowering blood lipids and reducing weight. Traditional medicine believes that lotus leaf has a bitter and neutral taste, and has the effects of clearing away heat and dampness, promoting the development of clear yang, clearing the heart and removing heat, and cooling blood and stopping bleeding. Hawthorn is the dried mature fruit of the plant Hawthorn, Crataegus pinnatifida, or Crataegus chinensis, all members of the Rosaceae family. Modern chemical research shows that hawthorn contains maslinic acid, flavonoids, lactones, sugars, glycosides, proteins, and essential elements such as calcium, phosphorus, and iron. Hawthorn has the benefits of promoting digestion, strengthening the stomach, and promoting qi and dispersing blood stasis. Summary of the Invention

[0006] In view of the above problems, the present invention provides a method for preparing a composition with a fat-reducing effect, comprising the following steps: step (1) preparing flavonoids from tangerine peel, step (2) preparing total flavonoids from stir-fried hawthorn, step (3) preparing an α-amylase inhibitor from white kidney bean powder, step (4) preparing mulberry leaf powder and lotus leaf powder, step (5) preparing extracts of radish seeds, cassia seeds and coix seeds, step (6) preparing a concentrated composition with a fat-reducing effect, step (7) preparing a secondary concentrated composition, and step (8) preparing a composition with a fat-reducing effect.

[0007] The present invention creatively uses tangerine peel, white kidney bean powder, stir-fried hawthorn, and lotus leaf to prepare a low-calorie, high-satisfaction composition product with a significant effect of regulating phlegm-damp constitution. During the preparation process, solvent extraction, turbidity point extraction, and microwave-assisted extraction are creatively used to extract α-amylase inhibitors, flavonoids, and total flavonoids, respectively. Among them, lotus leaf clears away heat and dampness, promotes the flow of clear yang, cools blood and stops bleeding, cassia seed clears heat and improves eyesight, moistens the intestines and promotes bowel movements, coix seed promotes diuresis and dampness, strengthens the spleen and stops diarrhea, eliminates numbness, discharges pus, detoxifies and disperses stagnation, mulberry leaf dispels wind-heat, clears the lungs and moistens dryness, clears the liver and improves eyesight, passion flower promotes fluid production and relieves sore throat, moistens the intestines and promotes bowel movements, strengthens the spleen and stimulates appetite, radish seed helps digestion and relieves bloating, lowers qi and resolves phlegm, hawthorn helps digestion and strengthens the stomach, promotes qi and disperses blood stasis, resolves turbidity and reduces lipids, white kidney bean lowers blood lipids, beautifies, and reduces weight, tangerine peel regulates qi and relieves fullness, dries dampness and resolves phlegm. Resistant dextrin (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy isolate, whey protein, monolaurin, etc. mainly provide satiety and protein, and reduce calorie intake.

[0008] As a preferred method, step (1) preparation of flavonoids from tangerine peel Weigh and clean the tangerine peel, cut it into small pieces, dry it to constant weight, crush it, and sieve it to obtain a coarse tangerine peel powder; accurately weigh the tangerine peel powder and put it into a stainless steel multi-functional extraction tank, add ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power and extraction time, and after the extraction is completed, use activated carbon to decolorize the solution, introduce the decolorized solution into a volumetric mixing tank, add ethanol to the final volume, and store the obtained tangerine peel extract for future use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, sieved, and the hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. Polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto, stirred evenly, and centrifuged after ultrasonication. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The solution was centrifuged in a water bath until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge. Ethanol was added to the upper organic layer to reduce the viscosity. The layer was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the hawthorn total flavonoid extract. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with plump, white and shiny grains, crush them into powder using a high-speed grinder, sieve, accurately weigh the white kidney bean powder, extract with water, adjust the material-liquid ratio and pH value, extract the sample liquid in a water bath, centrifuge and collect the supernatant: rotary evaporate the supernatant to obtain the crude α-amylase inhibitor extract of white kidney bean powder; Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind dried lotus leaves and mulberry leaves, mix the lotus leaf powder and mulberry leaf powder, sieve, extract with water in a boiling water bath, cool and let stand, filter and add water to obtain water extracts of lotus leaves and mulberry leaves; Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts Radish seeds, cassia seeds, and coix seeds are ground, ethanol is added, the container is sealed, and the mixture is placed in a cool and ventilated place for soaking; the extract is extracted after heating and the extract is taken out; the obtained extract solution is placed in a round-bottom flask of a rotary evaporator, and the rotation speed and heating temperature are set; the rotary evaporator is started, and after the solvent evaporates to the desired concentration, the heating device is turned off and the rotation is stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take tangerine peel flavonoids extract, hawthorn total flavonoids extract, white kidney bean powder α-amylase inhibitor crude extract, lotus leaf and mulberry leaf mixed extract, radish seed, cassia seed, coix seed mixed concentrated extract, add purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition The centrifugal spray dryer is started, and the inlet air temperature, outlet air temperature, feed flow rate, and atomizer speed are set; when the equipment reaches the set temperature, the feed pump is started, and the concentrated composition is slowly added, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, the feed pump is turned off and the heater is stopped to obtain a secondary concentrated composition, which contains tangerine peel, white kidney bean powder, mulberry leaf, stir-fried hawthorn, lotus leaf, radish seed, coix seed, cassia seed, and passion fruit powder; Step (8) Luo's composition for resolving phlegm and dampness and conditioning the body with fat-reducing effect Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, isolated soy protein, whey protein, and monolaurin are added to the double-effect concentrated composition, and the mixture is stirred until completely uniform. Ethanol is added thereto as a wetting agent, and the soft material is now prepared; the soft material is formed into lumps and lightly pressed through a sieve; the obtained wet granules are immediately placed in a drying oven for drying; after the drying is completed, some block granules that are not fully separated are re-granulated to ensure that all materials are uniform granules; and tablets are pressed using a tablet press to finally obtain Luo's composition for resolving phlegm, purging turbidity, and treating phlegm-damp constitution with fat-reducing effect.

[0009] As a preferred method, step (1) preparation of flavonoids from tangerine peel Weigh 65-80 kg of tangerine peel, clean it, cut it into small pieces, dry it at 50-65°C to constant weight, grind it and pass it through a 50-70 mesh sieve to obtain tangerine peel coarse powder; accurately weigh 8-11 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 60-75 L of 65-80% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system for microwave extraction reaction, adjust the power to 400-700 W, and extract for 7-10 min. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume of 80-110 L. The obtained tangerine peel extract is stored for later use.

[0010] The advantage of adopting the present invention is that microwave extraction is a relatively safe extraction method. Compared with traditional heating reflux extraction, the microwave extraction time is short (7 to 10 minutes), which reduces the safety risks that may be caused by long-term heating during the experiment. A relatively small amount of ethanol (60 to 75 L) is used in the experiment, and ethanol is a relatively environmentally friendly organic solvent. Compared with other toxic organic solvents (such as chloroform and benzene), it pollutes the environment less.

[0011] As a preferred method, step (2) preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 50-70 mesh sieve. 8-11 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 180-210 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonic treatment at 200-500 W for 20-35 min, the mixture was centrifuged at 600-900 rpm for 3-6 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 50-65°C water bath for 20-35 min and centrifuged at 600-900 rpm for 8-11 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, and 10-25 L of ethanol was added to the upper organic layer to reduce the viscosity. The mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn.

[0012] The advantages of the present invention are that ultrasonic-assisted extraction is an efficient and rapid extraction method, and the extraction efficiency can be significantly improved and the extraction time can be shortened (20 to 35 minutes) through the cavitation effect of ultrasound. Compared with the traditional heating reflux extraction method, the experimental efficiency is greatly improved, and two centrifugation operations (600 to 900 rpm, 3 to 11 minutes) are used to perform turbidity point extraction, which can quickly separate solid impurities and liquids of different phases, ensuring the purity of the extract, while reducing the time waste caused by long-term static stratification, and recovering the polyoxyethylene fatty alcohol ether through ultrafiltration membrane filtration, thereby reducing the waste of organic solvents and pollution to the environment.

[0013] As a preferred method, step (3) preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 20-50 mesh sieve, accurately weigh 30-60 kg of white kidney bean powder, extract with water, the material-liquid ratio is 1:3-1:6 (W / V), the pH value is 4.0-7.0, and the sample solution is extracted in a water bath at 45-60℃ for 1-2.5 hours at 4000-4300 r·min. -1 Centrifuge for 8-11 minutes and take the supernatant: rotary evaporate the supernatant to 60-90% of the original volume at 45-60°C and 70-100 MPa. The resulting liquid is the crude α-amylase inhibitor extract of white kidney bean flour.

[0014] The advantage of adopting the present invention is that no inorganic salts or organic solvents are introduced during the entire extraction process, thereby avoiding the impact of chemical residues on product quality and safety of use. The extracted α-amylase inhibitor has high biological activity and can effectively inhibit the activity of starch-digesting enzymes, thus having good application prospects in the management of obesity and diabetes.

[0015] As a preference, step (4) preparation of mulberry leaf powder and lotus leaf powder Grind 65-80 kg of dried lotus leaves and 40-55 kg of mulberry leaves, mix 13-16 kg of lotus leaf powder and 8-11 kg of mulberry leaf powder, pass through a 10-20 mesh sieve, extract with 8-11 times the amount of water in a boiling water bath for 10-25 min, cool and let stand at 2-5°C for 8-11 h, filter and add water to 8-11 L to obtain the water extract of lotus leaf and mulberry leaf.

[0016] The advantage of adopting the present invention is that boiling water bath extraction is a relatively mild extraction method, which avoids extreme conditions such as high temperature and high pressure, reduces the damage to the effective ingredients, and also reduces the safety risks in the operation.

[0017] Preferably, step (5) preparation of radish seed, cassia seed and coix seed extract 48-51 kg of radish seeds, 23-26 kg of cassia seeds, and 23-26 kg of coix seeds are taken, crushed, and 8-11 times the amount of 60-90% ethanol is added. The container is sealed and placed in a cool and ventilated place for soaking for 24-48 hours; the mixture is heated at above 60-90°C for 1-2 times, each time for 0.5-1 hour, and the extract is taken out; the obtained extract solution is placed in a round-bottom flask of a rotary evaporator, the rotation speed is set to 100-130 rpm, and the heating temperature is set to 73-76°C; the rotary evaporator is started, and after the solvent evaporates to the expected concentration, the heating device is turned off and the rotation is stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds.

[0018] The advantages of adopting the present invention are that radish seeds, cassia seeds and coix seeds are all common Chinese medicinal materials with relatively low cost and wide sources. Through multiple extractions and rotary evaporation concentration, the content of effective ingredients in the extract is ensured and the quality of the extract is improved. Concentration is performed by a rotary evaporator, and the solvent can be evaporated to the expected concentration level in a relatively short time, thereby improving efficiency.

[0019] Preferably, the fat-reducing concentrated composition in step (6) Take 1-4 L of tangerine peel flavonoids extract, 1-4 kg of hawthorn total flavonoids extract, 1-4 L of white kidney bean powder crude α-amylase inhibitor extract, 3-6 L of a mixed extract of lotus leaves and mulberry leaves, 2-5 kg ​​of a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds, add 1-2 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition.

[0020] Preferably, the composition of the secondary concentration in step (7) Start the centrifugal spray dryer, set the inlet air temperature to 150℃~180℃, and control the outlet air temperature to 70℃~100℃. The feed flow rate is set to 50-200 mL / h according to the equipment model and material properties, and the atomizer speed is set to 15000-25000 r / min. When the equipment reaches the set temperature, the feed pump is started and the concentrated composition is slowly added. The dried solid particles are collected by a cyclone separator and recovered by a bag filter. After the collection is completed, the feed pump is turned off and the heater is stopped to obtain 8-11 kg of a secondary concentrated composition, which contains 1.3-1.6 kg of tangerine peel, 1.3-1.6 kg of white kidney bean powder, 0.8-1.1 kg of mulberry leaves, 1.3-1.6 kg of stir-fried hawthorn, 1.3-1.6 kg of lotus leaves, 0.8-1.1 kg of radish seeds, 0.3-0.6 kg of coix seeds, 0.3-0.6 kg of cassia seeds, and 0.8-1.1 kg of passion fruit powder.

[0021] The advantages of the present invention are that spray drying is an efficient drying technology that can dry liquid materials into solid particles in a short time. By setting appropriate air inlet temperature (150°C to 180°C) and air outlet temperature (70°C to 100°C), the solvent can be evaporated quickly, thereby improving the drying efficiency. The high rotation speed of the centrifugal atomizer can atomize the material into uniform fine droplets. The solid particles obtained after drying have uniform particle size and stable quality. Through dual collection by a cyclone separator and a bag filter, the solid particles and exhaust gas can be effectively separated, the mixing of impurities can be reduced, and the purity of the product can be improved.

[0022] Preferably, the centrifugal spray dryer for preparing a secondary concentrated composition of the present invention comprises a dryer body, a support frame is provided on the dryer body, an atomizer is provided at the top of the dryer body, an air inlet device is provided at the top of the atomizer, a feed pipe is provided on the side of the atomizer, a feed pump is provided on the side of the top of the support frame, one end of the feed pipe is connected to the feed pump, a controller is provided on the side of the support frame, a discharge pipe is provided at the bottom of the dryer body, a cyclone separator is provided at one end of the discharge pipe, an air outlet pipe is provided at the bottom of one side of the cyclone separator, and an exhaust gas treatment device is provided on the air outlet pipe.

[0023] Furthermore, the present invention is improved in that a driving motor is provided on the side of the dryer body, a transmission rod is provided inside the dryer body, one end of the transmission rod is connected to the output end of the driving motor, and the transmission rod is provided with stirring blades, and a plurality of stirring blades are provided and are evenly arranged on the transmission rod.

[0024] Furthermore, the present invention is improved in that the air inlet device includes a fan, a pipe and a heater, and the fan and the heater are arranged inside the pipe.

[0025] Furthermore, the present invention is improved in that the atomizer is a high-speed centrifugal atomizer.

[0026] Furthermore, the present invention is improved in that a temperature sensor is provided in the air outlet pipe.

[0027] Furthermore, the present invention is improved in that the inner wall of the cyclone separator is coated with a wear-resistant material.

[0028] Furthermore, the present invention is improved in that the feed pump adopts a peristaltic pump controlled by variable frequency.

[0029] Furthermore, the present invention is improved in that the controller adopts a PLC automatic control system, and the controller includes an integrated touch screen operation interface.

[0030] The centrifugal spray drying device of the present invention can significantly improve the heat transfer efficiency of hot air by setting reasonable air inlet temperature and air outlet temperature, can quickly evaporate the solvent, improve drying efficiency, and obtain solid particles of uniform particle size. The fine droplets produced by the atomizer are uniform in size, and the particle size of the solid particles formed after drying is also more consistent, avoiding the problem of uneven particle size that may occur in traditional drying methods.

[0031] As a preferred method, step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Add dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin to the double-effect concentrated composition, mix and stir for 8 minutes to 11 minutes until completely uniform, and then add 70% to 85% ethanol as a wetting agent. At this time, the soft material is prepared; the soft material is squeezed into a mass and lightly pressed through a 10-20 mesh sieve; the obtained wet granules are immediately placed in a drying oven at 55-70°C for drying; after the drying is completed, the partially separated The block particles are then sieved through a 10-20 mesh sieve to ensure that all materials are uniform particles; and tablets are pressed using a tablet press, wherein each tablet contains 1.3-1.6g of tangerine peel, 1.3-1.6g of white kidney bean powder, 0.8-1.1g of mulberry leaf, 1.3-1.6g of stir-fried hawthorn, 1.3-1.6g of lotus leaf, 0.8-1.1g of radish seed, 0.3-0.6g of coix seed, 0.3-0.6g of cassia seed, and 0.8-1.1g of passionflower powder, thereby finally preparing the Luo's composition for resolving phlegm, dispelling turbidity, and regulating phlegm-damp constitution with fat-reducing effect.

[0032] The advantages of the present invention are that, through two screening operations, the sizes of all particles are ensured to be consistent, which is conducive to the uniformity and stability of tablets during the tableting process; the drying temperature is controlled within a relatively low temperature range of 55-70°C, thereby avoiding the damage of heat-sensitive components caused by high temperature and reducing the safety risks that may be caused by high-temperature operation; and the addition of ethanol as a wetting agent can effectively improve the formability of the particles, reduce dust, and improve the compressibility of the particles.

[0033] In summary, the present invention has the following beneficial effects: 1. The present invention has the advantages of being a relatively safe extraction method. Compared with traditional heating and reflux extraction, microwave extraction takes a short time (7 to 10 minutes), reducing the safety risks that may be caused by prolonged heating during the experiment. A relatively small amount of ethanol (60 to 75 L) is used in the experiment. Ethanol is a relatively environmentally friendly organic solvent and is less polluting to the environment than other toxic organic solvents (such as chloroform and benzene). 2. The present invention has the advantages of being an efficient and rapid extraction method. The ultrasonic cavitation effect can significantly improve the extraction efficiency and shorten the extraction time (20 to 35 minutes). Compared with the traditional heating and reflux extraction method, the experimental efficiency is greatly improved. The cloud point extraction performed by two centrifugation operations (600 to 900 rpm, 3 to 11 minutes) can quickly separate solid impurities and different phases of liquid, ensuring the purity of the extract. At the same time, the time wasted due to long-term static stratification is reduced. The polyoxyethylene fatty alcohol ether is recovered by filtration with an ultrafiltration membrane, reducing the waste of organic solvents and environmental pollution. 3. The present invention has the advantage of not introducing inorganic salts or organic solvents during the entire extraction process, thus avoiding the impact of chemical residues on product quality and safety. The extracted α-amylase inhibitor has high biological activity and can effectively inhibit the activity of starch-digesting enzymes, showing good application prospects in the management of obesity and diabetes. 4. The advantage of the present invention is that boiling water bath extraction is a relatively mild extraction method, which avoids extreme conditions such as high temperature and high pressure, reduces the damage to the active ingredients, and also reduces the safety risks in the operation; 5. The advantages of the present invention are that radish seeds, cassia seeds, and coix seeds are all common Chinese medicinal materials with relatively low cost and wide sources. Multiple extractions and rotary evaporation concentrations ensure the content of active ingredients in the extract and improve the quality of the extract. Concentration by rotary evaporation can evaporate the solvent to the desired concentration level in a relatively short time, thereby improving efficiency. 6. The advantages of the present invention are that spray drying is a highly efficient drying technology that can dry liquid materials into solid particles in a short period of time. By setting appropriate inlet air temperature (150°C to 180°C) and outlet air temperature (70°C to 100°C), the solvent can be evaporated quickly, improving drying efficiency. The high speed of the centrifugal atomizer can atomize the material into uniform fine droplets. The solid particles obtained after drying have uniform particle size and stable quality. The dual collection of the cyclone separator and bag filter can effectively separate the solid particles and exhaust gas, reduce the mixing of impurities, and improve the purity of the product. 7. The present invention has the advantages of ensuring that all particles are of uniform size through two screening operations, which helps to ensure the uniformity and stability of tablets during the tableting process. The drying temperature is controlled at 55-70°C, which is in a relatively low temperature range, avoiding the damage of heat-sensitive components caused by high temperature and also reducing the safety risks that may be caused by high temperature operation. The addition of ethanol as a wetting agent can effectively improve the formability of the particles, reduce dust, and improve the compressibility of the particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 It is a flow chart of a method for preparing a composition having fat-reducing effect; Figure 2 This is a schematic structural diagram of a centrifugal spray dryer specific to the present invention; Figure 3 For the present invention Figure 2 A side structural diagram of Figure 4 For the present invention Figure 3 Schematic diagram of the internal structure of the dryer body; Figure 5 For the present invention Figure 4 A side structural diagram of In the figure: 1. Dryer body; 2. Atomizer; 3. Air inlet device; 4. Feed pipe; 5. Feed pump; 6. Support frame; 7. Controller; 8. Discharge pipe; 9. Cyclone separator; 10. Air outlet pipe; 11. Exhaust gas treatment device; 12. Drive motor; 13. Transmission rod; 14. Stirring blade. DETAILED DESCRIPTION

[0035] The following examples are provided to illustrate the present invention but are not intended to limit the scope of the present invention. Without departing from the spirit and substance of the present invention, modifications or substitutions made to the methods, steps or conditions of the present invention are within the scope of the present invention.

[0036] Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art. In addition, all the components and raw materials used in the examples are known commercial products.

[0037] Example 1

[0038] Step (1) Preparation of flavonoids from tangerine peel Weigh 65 kg of tangerine peel, clean it, cut it into small pieces, dry it at 50°C to constant weight, grind it, and pass it through a 50-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 8 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 60 L of 65% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power to 400 W, and extract for 7 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume to 80 L. The obtained tangerine peel extract is stored for later use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 50-mesh sieve. 8 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 180 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 200W for 20 minutes, the mixture was centrifuged at 600 rpm for 3 minutes. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 50°C water bath for 20 minutes and centrifuged at 600 rpm for 8 minutes until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, and 10 L of ethanol was added to the upper organic layer to reduce the viscosity. The mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 20-mesh sieve, accurately weigh 30 kg of white kidney bean powder, extract with water, the material-liquid ratio is 1:3 (W / V), the pH value is 4.0, and the sample liquid is extracted in a 45℃ water bath for 1 hour, 4000 r·min -1Centrifuge for 8 minutes and take the supernatant: rotary evaporate the supernatant to 60% of the original volume at 45°C and 70 MPa. The obtained liquid is the crude α-amylase inhibitor extract of white kidney bean flour; Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind 65 kg of dried lotus leaves and 40 kg of mulberry leaves, mix 13 kg of lotus leaf powder and 8 kg of mulberry leaf powder, pass through a 10-mesh sieve, extract with 8 times the amount of water in a boiling water bath for 10 min, cool and let stand at 2°C for 8 h, filter and add water to 8 L to obtain the water extract of lotus leaves and mulberry leaves; Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts Take 48 kg of radish seeds, 23 kg of cassia seeds, and 23 kg of coix seeds, crush them, add 8 times the amount of 60% ethanol, seal the container, place it in a cool and ventilated place to soak for 24 hours, heat it above 60 ° C and extract it once, each time for 0.5 h, take out the extract, and put the obtained extract solution into a round-bottom flask of a rotary evaporator, set the rotation speed to 100 rpm, the heating temperature to 73 ° C, start the rotary evaporator, and after the solvent evaporates to the expected concentration, turn off the heating device and stop rotating to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take 1 L of tangerine peel flavonoids extract, 1 kg of hawthorn total flavonoids extract, 1 L of crude α-amylase inhibitor extract of white kidney bean powder, 3 L of mixed extract of lotus leaf and mulberry leaf, 2 kg of mixed concentrated extract of radish seed, cassia seed, and coix seed, add 1 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition Start the centrifugal spray dryer, set the inlet air temperature to 150 ° C, the outlet air temperature is controlled at 70 ° C, the feed flow rate is set to 50 mL / h according to the equipment model and material properties, the atomizer speed is set to 15000 r / min, when the equipment reaches the set temperature, start the feed pump, slowly add the concentrated composition, the dried solid particles are collected by a cyclone separator, and recovered by a bag filter. After the collection is completed, the feed pump is turned off and the heater is stopped to obtain 8 kg of a secondary concentrated composition, which contains 1.3 kg of tangerine peel, 1.3 kg of white kidney bean powder, 0.8 kg of mulberry leaves, 1.3 kg of fried hawthorn, 1.3 kg of lotus leaves, 0.8 kg of radish seeds, 0.3 kg of coix seeds, 0.3 kg of cassia seeds, and 0.8 kg of passion fruit powder; Step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin were added to the double-effect concentrated composition, and the mixture was stirred for 8 minutes until it was completely uniform. 70% ethanol was added as a wetting agent. At this time, the soft material was prepared; the soft material was formed into a mass and lightly pressed through a 10-mesh sieve; the obtained wet granules were immediately placed in a drying oven at 55°C for drying; the drying result was After bundling, some block particles that are not fully separated are sieved through a 10-mesh sieve to ensure that all materials are uniform particles; tablets are pressed using a tablet press, wherein each tablet contains 1.3g of tangerine peel, 1.3g of white kidney bean powder, 0.8g of mulberry leaf, 1.3g of stir-fried hawthorn, 1.3g of lotus leaf, 0.8g of radish seed, 0.3g of coix seed, 0.3g of cassia seed, and 0.8g of passion fruit powder, and finally the Luo's composition with the effect of resolving phlegm, purging turbidity, and conditioning phlegm-damp constitution and fat-reducing effect is prepared.

[0039] Example 2

[0040] Step (1) Preparation of flavonoids from tangerine peel Weigh 70 kg of tangerine peel, clean it, cut it into small pieces, dry it at 55°C to constant weight, grind it, and pass it through a 60-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 9 kg of tangerine peel powder and place it in a stainless steel multi-functional extraction tank. Add 65 L of 70% ethanol, and then perform microwave extraction using an industrial-grade multi-mode cavity microwave continuous reaction system. The power is adjusted to 500 W and the extraction time is 8 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized solution is introduced into a volumetric mixing tank. Ethanol is added to the final volume to 90 L. The obtained tangerine peel extract is stored for future use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 60-mesh sieve. 9 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 190 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 300 W for 25 min, the mixture was centrifuged at 700 rpm for 4 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was incubated in a 55°C water bath for 25 min and centrifuged at 700 rpm for 9 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, and 15 L of ethanol was added to the upper organic layer to reduce the viscosity. The mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 30-mesh sieve, accurately weigh 40 kg of white kidney bean powder, extract it with water, the material-liquid ratio is 1:4 (W / V), the pH value is 5.0, and the sample solution is extracted in a 50℃ water bath for 1.5 h, 4100 r·min -1Centrifuge for 9 minutes and take the supernatant: rotary evaporate the supernatant to 70% of the original volume at 50°C and 80 MPa. The obtained liquid is the crude α-amylase inhibitor extract of white kidney bean flour; Step (4) Preparation of mulberry leaf powder and lotus leaf powder 70 kg of dried lotus leaves and 45 kg of mulberry leaves were ground into powder, 14 kg of lotus leaf powder and 9 kg of mulberry leaf powder were mixed, and the mixture was passed through a 10-mesh sieve. The mixture was extracted with 9 times the amount of water in a boiling water bath for 15 min. After cooling, the mixture was allowed to stand at 3°C ​​for 9 h. After filtering, the mixture was filled up to 9 L with water to obtain the aqueous extract of lotus leaves and mulberry leaves. Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts 49 kg of radish seeds, 24 kg of cassia seeds, and 24 kg of coix seeds were crushed, and 9 times the amount of 70% ethanol was added. The container was sealed and placed in a cool and ventilated place to soak for 30 hours; the mixture was heated to above 70°C and extracted once for 0.5 hours each time, and the extract was taken out; the obtained extract solution was placed in a round-bottom flask of a rotary evaporator, the rotation speed was set to 110 rpm, and the heating temperature was set to 74°C; the rotary evaporator was started, and after the solvent evaporated to the desired concentration, the heating device was turned off and the rotation was stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take 2 L of tangerine peel flavonoids extract, 2 kg of hawthorn total flavonoids extract, 2 L of white kidney bean powder α-amylase inhibitor crude extract, 4 L of lotus leaf and mulberry leaf mixed extract, 3 kg of radish seed, cassia seed, and coix seed mixed concentrated extract, add 1 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition Start the centrifugal spray dryer, set the inlet air temperature to 160 ° C, and the outlet air temperature to 80 ° C; the feed flow rate is set to 100 mL / h according to the equipment model and material properties, and the atomizer speed is set to 20000 r / min; when the equipment reaches the set temperature, start the feed pump, slowly add the concentrated composition, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, turn off the feed pump and stop the heater to obtain 9 kg of a secondary concentrated composition, which contains 1.4 kg of tangerine peel, 1.4 kg of white kidney bean powder, 0.9 kg of mulberry leaves, 1.4 kg of fried hawthorn, 1.4 kg of lotus leaves, 0.9 kg of radish seeds, 0.4 kg of coix seeds, 0.4 kg of cassia seeds, and 0.9 kg of passion fruit powder; Step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin were added to the double-effect concentrated composition, and the mixture was stirred for 9 minutes until it was completely uniform. 75% ethanol was added as a wetting agent. At this time, the soft material was prepared; the soft material was formed into a mass and lightly pressed through a 10-mesh sieve; the obtained wet granules were immediately placed in a drying oven at 60°C for drying; the drying result was After the bundle is bundled, some block particles that are not fully separated are sieved through a 10-mesh sieve to ensure that all materials are uniform particles; tablets are pressed using a tablet press, wherein each tablet contains 1.4g of tangerine peel, 1.4g of white kidney bean powder, 0.9g of mulberry leaf, 1.4g of stir-fried hawthorn, 1.4g of lotus leaf, 0.9g of radish seed, 0.4g of coix seed, 0.4g of cassia seed, and 0.9g of passion fruit powder, and finally the Luo's composition with the effect of resolving phlegm, purging turbidity, and conditioning phlegm-damp constitution and fat-reducing effect is prepared.

[0041] Example 3

[0042] Step (1) Preparation of flavonoids from tangerine peel Weigh 75 g of tangerine peel, clean it, cut it into small pieces, dry it at 60°C to constant weight, grind it, and pass it through a 60-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 10 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 70 L of 75% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power to 600 W, and extract for 9 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume to 100 L. The obtained tangerine peel extract is stored for later use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 60-mesh sieve. 10 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 200 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 400 W for 30 min, the mixture was centrifuged at 800 rpm for 5 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 60°C water bath for 30 min and centrifuged at 800 rpm for 10 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, 20 L of ethanol was added to the upper organic layer to reduce the viscosity, and the mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 40-mesh sieve, accurately weigh 50 kg of white kidney bean powder, extract it with water, the material-liquid ratio is 1:5 (W / V), the pH value is 6.0, and the sample liquid is extracted in a 55℃ water bath for 2 h, 4200 r·min -1Centrifuge for 10 minutes and take the supernatant: rotary evaporate the supernatant to 80% of the original volume at 55°C and 90 MPa. The obtained liquid is the crude α-amylase inhibitor extract of white kidney bean flour; Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind 75 kg of dried lotus leaves and 50 kg of mulberry leaves, mix 15 kg of lotus leaf powder and 10 kg of mulberry leaf powder, pass through a 20-mesh sieve, extract with 10 times the amount of water in a boiling water bath for 20 min, cool and let stand at 4°C for 10 h, filter and add water to 10 L to obtain the water extract of lotus leaves and mulberry leaves; Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts 50 kg of radish seeds, 25 kg of cassia seeds, and 25 kg of coix seeds were crushed, and 10 times the amount of 80% ethanol was added. The container was sealed and placed in a cool and ventilated place to soak for 40 hours; the mixture was heated to above 80°C and extracted twice, each time for 1 hour, and the extract was taken out; the obtained extract solution was placed in a round-bottom flask of a rotary evaporator, the rotation speed was set to 120 rpm, and the heating temperature was set to 75°C; the rotary evaporator was started, and after the solvent evaporated to the desired concentration, the heating device was turned off and the rotation was stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take 3 L of tangerine peel flavonoids extract, 3 kg of hawthorn total flavonoids extract, 3 L of white kidney bean powder α-amylase inhibitor crude extract, 5 L of lotus leaf and mulberry leaf mixed extract, 4 kg of radish seed, cassia seed, and coix seed mixed concentrated extract, add 2 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition Start a specific centrifugal spray dryer, set the inlet air temperature to 170°C, and control the outlet air temperature at 90°C; the feed flow rate is set to 150 mL / h according to the equipment model and material properties, and the atomizer speed is set to 20,000 r / min; when the equipment reaches the set temperature, start the feed pump and slowly add the concentrated composition, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, turn off the feed pump and stop the heater to obtain 10 kg of a secondary concentrated composition, which contains 1.5 kg of tangerine peel, 1.5 kg of white kidney bean powder, 1.0 kg of mulberry leaves, 1.5 kg of fried hawthorn, 1.5 kg of lotus leaves, 1.0 kg of radish seeds, 0.5 kg of coix seeds, 0.5 kg of cassia seeds, and 1.0 kg of passion fruit powder; See also Figure 2-5The centrifugal spray dryer of this embodiment includes a dryer body 1, a support frame 6 is provided on the dryer body 1, an atomizer 2 is provided at the top of the dryer body 1, an air inlet device 3 is provided at the top of the atomizer 2, a feed pipe 4 is provided on the side of the atomizer 2, a feed pump 5 is provided on the side of the top of the support frame 6, one end of the feed pipe 4 is connected to the feed pump 5, a controller 7 is provided on the side of the support frame 6, a discharge pipe 8 is provided at the bottom of the dryer body 1, a cyclone separator 9 is provided at one end of the discharge pipe 8, an air outlet pipe 10 is provided at the bottom of one side of the cyclone separator 9, an exhaust gas treatment device 11 is provided on the air outlet pipe 10, the air inlet device 3 includes a fan, a pipe and a heater, the fan and heater are arranged inside the pipe, and a temperature sensor is provided in the air outlet pipe 10.

[0043] During actual use of the above structure, the air inlet device 3 is first turned on by the controller 7, so that the heater in the air inlet device 3 is heated. After the fan is turned on, the air inlet temperature is set to 150°C~180°C, and the air outlet temperature at the air outlet pipe 10 is 70°C~100°C. When the dryer body 1 reaches the set temperature, the feed pump 5 is started and the concentrated composition is slowly added. The concentrated composition is atomized into fine droplets under the action of the atomizer 2, and heat is exchanged with the hot air to quickly evaporate the solvent to form solid particles. The dried solid particles enter the cyclone separator 9 through the discharge pipe 8 and are then collected by the cyclone separator 9. The fine particles that are not captured are recovered through the bag filter. After the collection is completed, the feed pump 5 is turned off and the heater is stopped to obtain a secondary concentrated composition. When exhausting, it will first be filtered through the exhaust gas treatment device 11. The exhaust gas treatment device 11 can filter harmful gases to ensure that the emissions meet environmental protection standards.

[0044] In this embodiment, a driving motor 12 is provided on the side of the dryer body 1, and a transmission rod 13 is provided inside the dryer body 1. One end of the transmission rod 13 is connected to the output end of the driving motor 12, and the transmission rod 13 is provided with a stirring blade 14. There are multiple stirring blades 14, which are evenly arranged on the transmission rod 13. The driving motor 12 drives the transmission rod 13, and the transmission rod 13 drives the stirring blade 14 to rotate, which can disperse the material during the rotation process, so that the atomizer 2 can spray evenly, which can improve the efficiency of material drying.

[0045] In this embodiment, the atomizer 2 is a high-speed centrifugal atomizer 2, and the separation efficiency can reach more than 90%. In this embodiment, the inner wall of the cyclone separator 9 is coated with a wear-resistant material, thereby extending the service life of the cyclone separator 9.

[0046] In this embodiment, the controller 7 adopts a PLC automatic control system, and the controller 7 includes an integrated touch screen operation interface, which can monitor and adjust parameters such as inlet air temperature, outlet air temperature, feed flow rate, and atomizer 2 speed in real time.

[0047] Step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin were added to the double-effect concentrated composition, and the mixture was stirred for 10 minutes until it was completely uniform. 80% ethanol was added as a wetting agent. At this time, the soft material was prepared; the soft material was formed into a mass and lightly pressed through a 20-mesh sieve; the obtained wet granules were immediately placed in a drying oven at 65°C for drying; and the mixture was dried. After completion, some of the block particles that were not fully separated were sieved through a 20-mesh sieve to ensure that all the materials were uniform particles; tablets were pressed using a tablet press, wherein each tablet contained 1.5g of tangerine peel, 1.5g of white kidney bean powder, 1.0g of mulberry leaf, 1.5g of stir-fried hawthorn, 1.5g of lotus leaf, 1.0g of radish seed, 0.5g of coix seed, 0.5g of cassia seed, and 1.0g of passion fruit powder, and finally the Luo's composition with the effect of reducing fat for resolving phlegm and turbidity and conditioning phlegm-damp constitution was prepared.

[0048] Example 4

[0049] Step (1) Preparation of flavonoids from tangerine peel Weigh 80 kg of tangerine peel, clean it, cut it into small pieces, dry it at 65°C to constant weight, grind it, and pass it through a 70-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 11 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 75 L of 80% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power to 700 W, and extract for 10 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume to 110 L. The obtained tangerine peel extract is stored for later use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 70-mesh sieve. 11 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 210 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 500 W for 35 minutes, the mixture was centrifuged at 900 rpm for 6 minutes. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was incubated in a 65°C water bath for 35 minutes and centrifuged at 900 rpm for 11 minutes until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, and 25 L of ethanol was added to the upper organic layer to reduce the viscosity. The mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 50-mesh sieve, accurately weigh 60 kg of white kidney bean powder, extract it with water, the material-liquid ratio is 1:6 (W / V), the pH value is 7.0, and the sample liquid is extracted in a 60℃ water bath for 2.5 hours at 4300 r·min -1 Centrifuge for 11 minutes, take the supernatant: rotary evaporate the supernatant to 90% of the original volume at 60°C and 100 MPa. The obtained liquid is the crude α-amylase inhibitor extract of white kidney bean flour; Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind 80 kg of dried lotus leaves and 55 kg of mulberry leaves, mix 16 kg of lotus leaf powder and 11 kg of mulberry leaf powder, pass through a 20-mesh sieve, extract with 11 times the amount of water in a boiling water bath for 25 min, cool and let stand at 5°C for 11 h, filter and add water to 11 L to obtain the water extract of lotus leaves and mulberry leaves; Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts 51 kg of radish seeds, 26 kg of cassia seeds, and 26 kg of coix seeds were taken, crushed, and 11 times the amount of 90% ethanol was added. The container was sealed and placed in a cool and ventilated place to soak for 48 hours; the mixture was heated to above 90°C and extracted twice, each time for 1 hour, and the extract was taken out; the obtained extract solution was placed in a round-bottom flask of a rotary evaporator, the rotation speed was set to 130 rpm, and the heating temperature was set to 76°C; the rotary evaporator was started, and after the solvent evaporated to the desired concentration, the heating device was turned off and the rotation was stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take 4 L of tangerine peel flavonoids extract, 4 kg of hawthorn total flavonoids extract, 4 L of crude α-amylase inhibitor extract of white kidney bean powder, 6 L of mixed extract of lotus leaf and mulberry leaf, 5 kg of mixed concentrated extract of radish seed, cassia seed, and coix seed, add 2 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition Start the centrifugal spray dryer, set the inlet air temperature to 180 ° C, and the outlet air temperature to 100 ° C; the feed flow rate is set to 200 mL / h according to the equipment model and material properties, and the atomizer speed is set to 25000 r / min; when the equipment reaches the set temperature, start the feed pump, slowly add the concentrated composition, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, turn off the feed pump and stop the heater to obtain 11 kg of a secondary concentrated composition, which contains 1.6 kg of tangerine peel, 1.6 kg of white kidney bean powder, 1.1 kg of mulberry leaves, 1.6 kg of fried hawthorn, 1.6 kg of lotus leaves, 1.1 kg of radish seeds, 0.6 kg of coix seeds, 0.6 kg of cassia seeds, and 1.1 kg of passion fruit powder; Step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin were added to the double-effect concentrated composition, and the mixture was stirred for 11 minutes until it was completely uniform. 85% ethanol was added as a wetting agent. At this time, the soft material was prepared; the soft material was formed into a mass and lightly pressed through a 20-mesh sieve; the obtained wet granules were immediately placed in a drying oven at 70°C for drying; and the mixture was dried. After completion, some of the block particles that were not fully separated were sieved through a 20-mesh sieve to ensure that all the materials were uniform particles; tablets were pressed using a tablet press, wherein each tablet contained 1.6g of tangerine peel, 1.6g of white kidney bean powder, 1.1g of mulberry leaves, 1.6g of stir-fried hawthorn, 1.6g of lotus leaves, 1.1g of radish seeds, 0.6g of coix seeds, 0.6g of cassia seeds, and 1.1g of passionflower powder, and finally the Luo's composition with the effect of reducing fat for resolving phlegm, purging turbidity, and conditioning phlegm-damp constitution was prepared.

[0050] Comparative Example 1

[0051] Step (1) Preparation of flavonoids from tangerine peel Weigh 75 kg of tangerine peel, clean it, cut it into small pieces, dry it at 60°C to constant weight, grind it, and pass it through a 60-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 10 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 70 L of 75% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power to 600 W, and extract for 9 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume to 100 L. The obtained tangerine peel extract is stored for later use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 60-mesh sieve. 10 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 200 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 400 W for 30 min, the mixture was centrifuged at 800 rpm for 5 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 60°C water bath for 30 min and centrifuged at 800 rpm for 10 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, 20 L of ethanol was added to the upper organic layer to reduce the viscosity, and the mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of mulberry leaf powder and lotus leaf powder Grind 75 kg of dried lotus leaves and 50 kg of mulberry leaves, mix 15 kg of lotus leaf powder and 10 kg of mulberry leaf powder, pass through a 20-mesh sieve, extract with 10 times the amount of water in a boiling water bath for 20 min, cool and let stand at 4°C for 10 h, filter and add water to 10 L to obtain the water extract of lotus leaves and mulberry leaves; Step (4) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts 50 kg of radish seeds, 25 kg of cassia seeds, and 25 kg of coix seeds were crushed, and 10 times the amount of 80% ethanol was added. The container was sealed and placed in a cool and ventilated place to soak for 40 hours; the mixture was heated to above 80°C and extracted twice, each time for 1 hour, and the extract was taken out; the obtained extract solution was placed in a round-bottom flask of a rotary evaporator, the rotation speed was set to 120 rpm, and the heating temperature was set to 75°C; the rotary evaporator was started, and after the solvent evaporated to the desired concentration, the heating device was turned off and the rotation was stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (5) Concentrated composition for fat-reducing effect Take 3L of tangerine peel flavonoids extract, 3kg of hawthorn total flavonoids extract, 5L of a mixed extract of lotus leaves and mulberry leaves, 4kg of a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds, add 2kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (6) Secondary Concentration Composition Start the centrifugal spray dryer, set the inlet air temperature to 170 ° C, and the outlet air temperature to 90 ° C; the feed flow rate is set to 150 mL / h according to the equipment model and material properties, and the atomizer speed is set to 20000 r / min; when the equipment reaches the set temperature, start the feed pump, slowly add the concentrated composition, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, turn off the feed pump and stop the heater to obtain 10 kg of a secondary concentrated composition, which contains 1.5 kg of tangerine peel, 1.0 kg of mulberry leaves, 1.5 kg of fried hawthorn, 1.5 kg of lotus leaves, 1.0 kg of radish seeds, 0.5 kg of coix seeds, 0.5 kg of cassia seeds, and 1.0 kg of passion fruit powder; Step (7) Composition for fat-reducing effect Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin are added to the double-effect concentrated composition, and the mixture is stirred for 10 minutes until it is completely uniform. 80% ethanol is added thereto as a wetting agent, and the soft material is now prepared; the soft material is formed into a mass and lightly pressed through a 20-mesh sieve; the obtained wet granules are immediately placed in a 65°C drying oven for drying; after the drying is completed, some of the block particles that are not fully separated are sieved through a 20-mesh sieve to ensure that all the materials are uniform particles; tablets are pressed using a tablet press to finally obtain a composition with a fat-reducing effect.

[0052] Comparative Example 2

[0053] Step (1) Preparation of flavonoids from tangerine peel Weigh 75 kg of tangerine peel, clean it, cut it into small pieces, dry it at 60°C to constant weight, grind it, and pass it through a 60-mesh sieve to obtain tangerine peel coarse powder; accurately weigh 10 kg of tangerine peel powder and place it in a stainless steel multi-functional extraction tank, add 70 L of 75% ethanol, and then perform microwave extraction using an industrial-grade multi-mode cavity microwave continuous reaction system. The power is adjusted to 600 W and the extraction time is 9 minutes. After the extraction is completed, it is decolorized with activated carbon, and the decolorized solution is introduced into a volumetric mixing tank. Ethanol is added to the final volume to 100 L. The obtained tangerine peel extract is stored for future use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 60-mesh sieve. 10 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 200 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 400 W for 30 min, the mixture was centrifuged at 800 rpm for 5 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 60°C water bath for 30 min and centrifuged at 800 rpm for 10 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, 20 L of ethanol was added to the upper organic layer to reduce the viscosity, and the mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the total flavonoid extract of hawthorn. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 40-mesh sieve, accurately weigh 50 kg of white kidney bean powder, extract it with water, the material-liquid ratio is 1:5 (W / V), the pH value is 6.0, and the sample liquid is extracted in a 55℃ water bath for 2 h, 4200 r·min -1 Centrifuge for 10 minutes and take the supernatant: rotary evaporate the supernatant to 80% of the original volume at 55°C and 90 MPa. The obtained liquid is the crude α-amylase inhibitor extract of white kidney bean flour; Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind 75 kg of dried lotus leaves and 50 kg of mulberry leaves, mix 15 kg of lotus leaf powder and 10 kg of mulberry leaf powder, pass through a 20-mesh sieve, extract with 10 times the amount of water in a boiling water bath for 20 min, cool and let stand at 4°C for 10 h, filter and add water to 10 L to obtain the water extract of lotus leaves and mulberry leaves; Step (5) Concentrated composition for fat-reducing effect Take 3 L of tangerine peel flavonoids extract, 3 kg of hawthorn total flavonoids extract, 3 L of white kidney bean powder α-amylase inhibitor crude extract, 5 L of lotus leaf and mulberry leaf mixed extract, add 2 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (6) Secondary Concentration Composition Start the centrifugal spray dryer, set the inlet air temperature to 170 ° C, and the outlet air temperature to 90 ° C; the feed flow rate is set to 150 mL / h according to the equipment model and material properties, and the atomizer speed is set to 20000 r / min; when the equipment reaches the set temperature, start the feed pump, slowly add the concentrated composition, and the dried solid particles are collected by a cyclone separator and recovered by a bag filter; after the collection is completed, turn off the feed pump and stop the heater to obtain 10 kg of a secondary concentrated composition, which contains 1.5 kg of tangerine peel, 1.5 kg of white kidney bean powder, 1.0 kg of mulberry leaves, 1.5 kg of fried hawthorn, 1.5 kg of lotus leaves, and 1.0 kg of passion fruit powder; Step (7) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin are added to the double-effect concentrated composition, and the mixture is stirred for 10 minutes until it is completely uniform. 80% ethanol is added thereto as a wetting agent, and the soft material is now prepared; the soft material is formed into a mass and lightly pressed through a 20-mesh sieve; the obtained wet granules are immediately placed in a 65°C drying oven for drying; after the drying is completed, some of the block particles that are not fully separated are sieved through a 20-mesh sieve to ensure that all the materials are uniform particles; tablets are pressed using a tablet press to finally obtain a composition with a fat-reducing effect.

[0054] The compositions for the treatment of phlegm-dampness constitution obtained in Examples 1 to 4 and the comparative examples 1 and 2 were tested. The specific testing methods are as follows: 1. Experimental methods Twenty subjects were screened for the treatment. Before treatment, each subject was asked to measure their height, weight, waist circumference, and other information in the morning on an empty stomach. During the product trial, each subject consumed a 35g sample with dinner, mixed with warm water, followed by 500ml of warm water. During the trial, they were advised to eat their normal breakfast and lunch, maintain a regular sleep and rest schedule, avoid staying up late, and eat a light diet. Avoid greasy or spicy foods. The trial lasted for one month. After the trial, each subject's weight, waist circumference, and other information were measured again, as before treatment.

[0055] Table 1 Statistics of weight loss effects of subjects

[0056] As can be seen from Table 1, the embodiment is more effective than the comparative example. The conditions of each subject before and after the product trial are shown in the table above: As can be seen from the table, after the product trial, each person's weight and waist circumference decreased to varying degrees, among which Example 3 had the largest decrease in weight and waist circumference, and the best effect; Comparative Example 1 had the worst effect, with the least decrease in weight and waist circumference; from the trial results, it can be seen that the sample made from the composition has a certain fat-reducing effect.

[0057] The successful fat-reducing effect of the composition is mainly due to the synergistic effect of its multiple ingredients and the good lifestyle coordination of the subjects during the trial period. The ingredients in the composition, such as lotus leaf, cassia seed, coix seed, mulberry leaf, passion fruit, radish seed, hawthorn, white kidney bean and orange peel, each have the effects of promoting fat decomposition and metabolism, reducing fat absorption, regulating intestinal function, lowering blood lipids, and improving digestion. For example, the nuciferine in lotus leaf can inhibit fat absorption, the ingredients in cassia seed can stimulate intestinal peristalsis, the diuretic and dampness-removing effect of coix seed helps to reduce edema, and the alkaloids and flavonoids in mulberry leaf and hawthorn can regulate fat metabolism. At the same time, dietary fiber ingredients such as resistant dextrin, polydextrose, oligofructose, and maltitol provide a sense of fullness and reduce food intake; high-quality protein ingredients such as calcium caseinate, soy protein isolate, and whey protein not only enhance satiety, but also increase basal metabolic rate and promote fat burning. In addition, during the trial period, the subjects maintained a regular schedule, a light diet, and drank plenty of warm water after taking the sample. These good living habits further promoted metabolism, reduced calorie intake, and improved intestinal health, which, together with the ingredients of the composition, achieved significant fat-reducing effects.

[0058] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be considered as equivalent replacement methods and are included in the scope of protection of the present invention.

Claims

1. A method for preparing a composition having a fat-reducing effect, characterized in that: include: Step (1) preparation of flavonoids from tangerine peel, step (2) preparation of total flavonoids from stir-fried hawthorn, step (3) preparation of α-amylase inhibitor from white kidney bean powder, step (4) preparation of extracts from mulberry leaf powder and lotus leaf powder, step (5) preparation of extracts from radish seeds, cassia seeds and coix seeds, step (6) preparation of a concentrated composition with fat-reducing effect, step (7) preparation of a secondary concentrated composition, and step (8) preparation of a composition with fat-reducing effect.

2. The method for preparing the composition having fat-reducing effect according to claim 1, wherein: Step (1) Preparation of flavonoids from tangerine peel Weigh and clean the tangerine peel, cut it into small pieces, dry it to constant weight, crush it, and then sieve it to obtain a tangerine peel coarse powder; weigh the tangerine peel powder and put it into a stainless steel multi-functional extraction tank, add ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system to perform microwave extraction reaction, adjust the power and extraction time, and after the extraction is completed, use activated carbon to decolorize the solution, introduce the decolorized solution into a volumetric mixing tank, add ethanol to the final volume, and store the obtained tangerine peel extract for future use; Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, crushed, and sieved. The hawthorn powder was weighed and placed in a stainless steel multifunctional extraction tank. Polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication, the supernatant was centrifuged and an appropriate amount of NaCl solution was added and mixed evenly. The solution was centrifuged in a water bath until it was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge. Ethanol was added to the upper organic layer to reduce the viscosity. The layer was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated by a thin film evaporation system to obtain the hawthorn total flavonoid extract. Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with plump, white and shiny grains, crush them into powder using a high-speed grinder, sieve and weigh the white kidney bean powder, extract it with water, control the material-liquid ratio and pH value, extract the sample liquid in a water bath, centrifuge and collect the supernatant, and rotary evaporate the supernatant to obtain the crude α-amylase inhibitor extract of the white kidney bean powder; Step (4) Preparation of mulberry leaf powder and lotus leaf powder extract Grind dried lotus leaves and mulberry leaves, mix the lotus leaf powder and mulberry leaf powder, sieve, extract with water in a boiling water bath, cool, let stand, filter, and add water to obtain water extracts of lotus leaves and mulberry leaves; Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts Radish seeds, cassia seeds, and coix seeds are ground, ethanol is added, the container is sealed, and the mixture is placed in a cool and ventilated place for soaking; the extract is extracted after heating and the extract is taken out; the obtained extract solution is placed in a round-bottom flask of a rotary evaporator, and the rotation speed and heating temperature are set; the rotary evaporator is started, and after the solvent evaporates to the desired concentration, the heating device is turned off and the rotation is stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds; Step (6) Concentrated composition for fat-reducing effect Take tangerine peel flavonoids extract, hawthorn total flavonoids extract, white kidney bean powder α-amylase inhibitor crude extract, lotus leaf and mulberry leaf mixed extract, radish seed, cassia seed, coix seed mixed concentrated extract, add purchased passionflower powder, mix and stir evenly to obtain a concentrated composition; Step (7) Secondary Concentration Composition Start the centrifugal spray dryer and set the air inlet temperature, air outlet temperature, feed flow rate and atomizer speed. When the equipment reaches the set temperature, start the feed pump and slowly add the concentrated composition. The dried solid particles are collected by a cyclone separator and recovered by a bag filter. After the collection is completed, the feed pump is turned off and the heater is stopped to obtain a secondary concentrated composition, which contains tangerine peel, white kidney bean powder, mulberry leaves, stir-fried hawthorn, lotus leaves, radish seeds, coix seeds, cassia seeds, and passion fruit powder; Step (8) Luo's composition for reducing fat by eliminating phlegm and dampness Dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, isolated soy protein, whey protein, and monolaurin are added to the double-effect concentrated composition, and the mixture is stirred until completely uniform. Ethanol is then added thereto as a wetting agent, and the soft material is now prepared; the soft material is formed into lumps and lightly pressed through a sieve; the obtained wet granules are immediately placed in a drying oven for drying; after the drying is completed, some block particles that are not fully separated are sieved again to ensure that all the materials are uniform particles; and tablets are pressed using a tablet press to finally obtain a composition with a fat-reducing effect.

3. The method for preparing the composition having fat-reducing effect according to claim 2, wherein: Step (1) Preparation of flavonoids from tangerine peel Weigh 65-80 kg of tangerine peel, clean it, cut it into small pieces, dry it at 50-65°C to constant weight, crush it and pass it through a 50-70 mesh sieve to obtain tangerine peel coarse powder; accurately weigh 8-11 kg of tangerine peel powder, put it into a stainless steel multi-functional extraction tank, add 60-75 L of 65-80% ethanol, and then use an industrial-grade multi-mode cavity microwave continuous reaction system for microwave extraction reaction, adjust the power to 400-700 W, and the extraction time is 7-10 min. After the extraction is completed, it is decolorized with activated carbon, and the decolorized liquid is introduced into a volumetric mixing tank, and ethanol is added to the final volume of 80-110 L. The obtained tangerine peel extract is stored for later use.

4. The method for preparing the composition having fat-reducing effect according to claim 3, wherein: Step (2) Preparation of total flavonoids in stir-fried hawthorn The hawthorn was dried, seeded, and crushed, and passed through a 50-70 mesh sieve. 8-11 kg of hawthorn powder was accurately weighed and placed in a stainless steel multifunctional extraction tank. 180-210 L of polyoxyethylene fatty alcohol ether (Genapol-X80) was added thereto and stirred evenly. After ultrasonication at 200-500 W for 20-35 min, the mixture was centrifuged at 600-900 rpm for 3-6 min. The supernatant was added with an appropriate amount of NaCl solution and mixed evenly. The mixture was in a 50-65°C water bath for 20-35 min and centrifuged at 600-900 rpm for 8-11 min until the solution was clearly separated into two layers. The lower aqueous phase was separated by a disc centrifuge, and 10-25 L of ethanol was added to the upper organic layer to reduce the viscosity. The mixture was filtered with an ultrafiltration membrane to recover the polyoxyethylene fatty alcohol ether. The filtrate was evaporated through a thin film evaporation system to obtain the total flavonoid extract of hawthorn.

5. The method for preparing the composition having fat-reducing effect according to claim 4, characterized in that: Step (3) Preparation of α-amylase inhibitor in white kidney bean powder Select white kidney beans with full, white and bright grains, crush them into powder with a high-speed grinder, pass them through a 20-50 mesh sieve, accurately weigh 30-60 kg of white kidney bean powder, extract with water, the material-liquid ratio is 1:3-1:6 (W / V), the pH value is 4.0-7.0, and the sample solution is extracted in a water bath at 45-60℃ for 1-2.5 hours at 4000-4300 r·min. -1 Centrifuge for 8-11 minutes and take the supernatant: rotary evaporate the supernatant to 60-90% of the original volume at 45-60°C and 70-100 MPa. The resulting liquid is the crude α-amylase inhibitor extract of white kidney bean flour.

6. The method for preparing the composition having fat-reducing effect according to claim 5, characterized in that: Step (4) Preparation of mulberry leaf powder and lotus leaf powder Grind 65-80 kg of dried lotus leaves and 40-55 kg of mulberry leaves, mix 13-16 kg of lotus leaf powder and 8-11 kg of mulberry leaf powder, pass through a 10-20 mesh sieve, extract with 8-11 times the amount of water in a boiling water bath for 10-25 min, cool and let stand at 2-5°C for 8-11 h, filter and add water to 8-11 L to obtain the water extract of lotus leaf and mulberry leaf.

7. The method for preparing the composition having fat-reducing effect according to claim 6, characterized in that: Step (5) Preparation of Radish Seed, Cassia Seed and Coix Seed Extracts 48-51 kg of radish seeds, 23-26 kg of cassia seeds, and 23-26 kg of coix seeds are taken, crushed, and 8-11 times the amount of 60-90% ethanol is added. The container is sealed and placed in a cool and ventilated place for soaking for 24-48 hours; the mixture is heated at above 60-90°C for 1-2 times, each time for 0.5-1 hour, and the extract is taken out; the obtained extract solution is placed in a round-bottom flask of a rotary evaporator, the rotation speed is set to 100-130 rpm, and the heating temperature is set to 73-76°C; the rotary evaporator is started, and after the solvent evaporates to the expected concentration, the heating device is turned off and the rotation is stopped to obtain a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds.

8. The method for preparing the composition having fat-reducing effect according to claim 7, characterized in that: Step (6) Concentrated composition for fat-reducing effect Take 1-4 L of tangerine peel flavonoids extract, 1-4 kg of hawthorn total flavonoids extract, 1-4 L of white kidney bean powder crude α-amylase inhibitor extract, 3-6 L of a mixed extract of lotus leaves and mulberry leaves, 2-5 kg ​​of a mixed concentrated extract of radish seeds, cassia seeds, and coix seeds, add 1-2 kg of purchased passionflower powder, mix and stir evenly to obtain a concentrated composition.

9. The method for preparing the composition having fat-reducing effect according to claim 8, characterized in that: Step (7) Secondary Concentration Composition Start the centrifugal spray dryer, set the air inlet temperature to 150°C~180°C, and control the air outlet temperature to 70°C~100°C; set the feed flow rate to 50~200mL / h according to the equipment model and material properties, and set the atomizer speed to 15000~25000r / min; when the equipment reaches the set temperature, start the feed pump and slowly add the concentrated composition. The dried solid particles are collected by a cyclone separator and recovered by a bag filter; After the collection is completed, the feed pump is turned off and the heater is stopped to obtain 8-11 kg of a secondary concentrated composition, which contains 1.3-1.6 kg of tangerine peel, 1.3-1.6 kg of white kidney bean powder, 0.8-1.1 kg of mulberry leaves, 1.3-1.6 kg of fried hawthorn, 1.3-1.6 kg of lotus leaves, 0.8-1.1 kg of radish seeds, 0.3-0.6 kg of coix seeds, 0.3-0.6 kg of cassia seeds, and 0.8-1.1 kg of passion fruit powder.

10. The method for preparing the composition having fat-reducing effect according to claim 9, characterized in that: Step (8) Composition with fat-reducing effect Add dietary fiber (resistant dextrin, polydextrose, oligofructose, maltitol), calcium caseinate, soy protein isolate, whey protein, and monolaurin to the double-effect concentrated composition, stir for 8-11 minutes until completely uniform, and then add 70-85% ethanol as a wetting agent. At this time, the soft material is prepared; the soft material is formed into a mass and lightly pressed through a 10-20 mesh sieve; the obtained wet granules are immediately placed in a drying oven at 55-70°C for drying; after the drying is completed, the partially separated masses are removed. The granules are then sieved through a 10-20 mesh sieve to ensure that all the materials are uniform particles; tablets are pressed using a tablet press, wherein each tablet contains 1.3-1.6g of tangerine peel, 1.3-1.6g of white kidney bean powder, 0.8-1.1g of mulberry leaf, 1.3-1.6g of stir-fried hawthorn, 1.3-1.6g of lotus leaf, 0.8-1.1g of radish seed, 0.3-0.6g of coix seed, 0.3-0.6g of cassia seed, and 0.8-1.1g of passionflower powder, and finally the Luo's composition for resolving phlegm, dispelling turbidity, and conditioning phlegm-damp constitution with fat-reducing effect is prepared.

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