Coffee-containing composition with firming and anti-wrinkle effects, application and skin care product

Abstract

The invention belongs to the field of cosmetics, and discloses a coffee-containing composition with firming and anti-wrinkle effects, which comprises a caffeine composite component and an auxiliary component, the auxiliary component has at least one function of relieving, repairing a barrier, resisting oxidation and improving mitochondrial energy; the caffeine composite component is composed of a coffee seed extract, a caffeine inclusion and a cocoa extract; the caffeine inclusion is prepared from cyclodextrin and caffeine; the weight ratio of the coffee seed extract to the caffeine inclusion to the cocoa extract is (0.0001-3): (0.01-6): (0.0001-6). The composition is prepared by combining three components which are rich in caffeine and similar caffeine, namely the caffeine seed extract, the caffeine inclusion and the cocoa extract, and is matched with the auxiliary components, so that very remarkable tightening and anti-wrinkle effects can be achieved. Meanwhile, the invention also provides related application of the composition.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care, and in particular to a coffee-containing composition with firming and anti-wrinkle effects, its use, and a skin care product. Background Art

[0002] Caffeine is increasingly being used in skincare products. It effectively penetrates the skin, stimulating the digestion and elimination of fat cells, and reduces excess weight by burning fat.

[0003] Some literature has studied the mechanism of caffeine applied on the skin surface for fat reduction, and it is believed that:

[0004] 1. Caffeine may affect the secretion of catecholamines, activate adrenergic receptors, increase cAMP concentration, and activate phosphorylated HSL during lipolysis;

[0005] 2. Applying caffeine to local areas can effectively promote the release of glycerin, reduce the formation of fat masses, and have a dissolving effect on orange peel tissue.

[0006] At the same time, caffeine has also been widely used in skin care, see the following literature:

[0007] The patent application with publication number CN111214410A, which is about a firming and anti-wrinkle composition containing sea fennel and its application, clearly states that caffeine has high antioxidant activity, can protect the skin from ultraviolet damage, and can also scavenge free radicals that are harmful to the skin.

[0008] In addition, in the patent application with publication number CN114588084A, which is about a dark circle removing, soothing and anti-wrinkle composition and eye mask and preparation method, it is clearly stated that the melatonin composition A includes Coffea arabica seed extract and caffeine.

[0009] The patent application with publication number CN118557488A, titled "A Firming Gel Containing Longan Seeds and Its Preparation Process," discloses that Arabica coffee seed extract has anti-inflammatory and antioxidant effects, can effectively reduce inflammatory responses, improve product applicability, and, when combined with caffeine, significantly enhances blood circulation and promotes the metabolism of excess water and fat, thereby effectively firming and inhibiting the formation of eye bags.

[0010] It can be seen that there is a relatively general consensus that the combination of Arabica coffee seed extract and caffeine can promote blood circulation and tighten the skin and fight against wrinkles.

[0011] The main purpose and research direction of this case is: based on the special functions of caffeine, to study its more in-depth efficacy in anti-wrinkle and firming. Summary of the Invention

[0012] One of the objectives of the present invention is to provide a coffee-containing composition with firming and anti-wrinkle effects. The composition combines three ingredients rich in caffeine and caffeine-like substances: Arabica coffee seed extract, caffeine inclusions, and cocoa extract, and is combined with auxiliary components to achieve very significant firming and anti-wrinkle effects.

[0013] At the same time, the invention also provides related applications of the composition.

[0014] To achieve the above objectives, the present invention provides a coffee-containing composition with firming and anti-wrinkle effects, comprising a caffeine composite component and an auxiliary component; the auxiliary component has at least one of the functions of soothing, barrier repair, anti-oxidation, and improving mitochondrial energy;

[0015] The caffeine composite component consists of Arabica coffee seed extract, caffeine inclusions, and cocoa extract;

[0016] The caffeine inclusions are composed of cyclodextrin and caffeine;

[0017] The weight ratio of the coffee arabica seed extract, the caffeine inclusions and the cocoa extract is 0.0001-3:0.01-6:0.0001-6.

[0018] All weight ratios and parts by weight described herein refer to the amounts of the active ingredients contained in the commercial raw materials. For example, if the cocoa extract in the raw material labeled Cacao Extract is 50 wt%, in actual use, the amount of Cacao Extract should be 0.0002-12. It should be noted that the amount of caffeine inclusions used refers to the content of the active ingredient, caffeine.

[0019] In the present invention, the commercial name of the Arabica coffee seed extract is Arabica coffee (COFFEA ARABICA) seed extract, and the supplier is Xinruiyang (Guangzhou) Biotechnology Co., Ltd.; its product manual indicates that the content of Arabica coffee (COFFEA ARABICA) seed extract is 100%; the manual states that its main functions are: 1. Antioxidant, the caffeine in Arabica coffee extract is an effective scavenger of hydroxyl free radicals and alkoxy free radicals, and also has a protective effect on human cells damaged by ultraviolet rays. This characteristic provides a certain basis for protecting skin cells from ultraviolet radiation-induced skin cancer. 2. Lightens dark circles, causes eye blood vessels to contract, and can accelerate blood circulation in the skin, and has a certain alleviating effect on vascular dark circles caused by staying up late, lack of sleep, and excessive fatigue; 3. Reduces puffiness, promotes the penetration and absorption of other active substances, has a firming and wrinkle-removing effect, promotes local metabolism, and reduces puffiness;

[0020] The caffeine inclusions, marketed as CAFFENERGY 50C, are supplied by Xianting (Guangzhou) Trading Co., Ltd. and consist of caffeine and cyclodextrin in a 1:1 weight ratio. The product brochure describes the product's features as follows: 1. Nano-encapsulation: The nanoscale carrier is less than 1nm, preventing it from penetrating the skin and causing excessive concentration and burden. Instead, it adheres to the skin's surface and continuously releases caffeine, enhancing bioavailability. 2. Fat-burning: Caffeine accelerates fat breakdown by inhibiting phosphodiesterase, thereby achieving a fat-burning effect. 3. Blood microcirculation stimulation: Caffeine has been shown to boost local metabolism, helping to alleviate edema and dark circles.

[0021] Cocoa extract, sold under the trade name Cacao Extract and supplied by Jung Do Chemical Co., Ltd., contains 50 wt% of THEOBROMA CACAO extract and 50% of dextrin. Its product brochure describes its benefits as being rich in antioxidants such as flavonoids, which effectively scavenge free radicals, protect against oxidative stress caused by environmental factors like ultraviolet rays and pollution, and slow skin aging, reducing wrinkles, sagging, and other signs of aging.

[0022] In the relevant experiments of the present invention, we verified that the above three ingredients, when combined with auxiliary components (lactobacillus / soy milk fermentation product filtrate, biosaccharide gum-1, glyceryl glucoside, and coenzyme Q10), can exhibit very significant firming and anti-wrinkle functions.

[0023] In the above-mentioned coffee-containing composition, the auxiliary components are composed of lactobacillus / soy milk fermentation product filtrate, biosaccharide gum-1, glycerol glucoside, and coenzyme Q10.

[0024] The trade name of Lactobacillus / soy milk fermentation product filtrate is OPTIMEALTH 10W, which is provided by Xianting (Guangzhou) Trading Co., Ltd. Its active ingredient (Lactobacillus / soy milk fermentation product filtrate) is 10wt%. According to its manual, it also contains 10wt% of butylene glycol, 2wt% of 1,2-pentanediol and the remainder of water. Its efficacy is described as: repairing the skin's five-layer barrier: 1. Microbial barrier: improves the diversity of beneficial bacteria on the skin surface and reduces inflammatory stimulation caused by the invasion of harmful bacteria; 2. Chemical barrier: maintains the skin at a healthy weakly acidic pH; 3. Physical barrier: promotes the production of keratinocytes; promotes the healing and regeneration of damaged tissues; and instantly increases the skin's water content. Moisturizes and strengthens the skin barrier; 4. Biological barrier: promotes the synthesis of collagen in the dermis, reduces wrinkles, and tightens the skin; 5. Immune barrier: anti-inflammatory and soothing, prevents immune system imbalance, soothes the skin, and reduces allergies;

[0025] The trade name of Biosaccharide Gum-1 is Biopolysaccharide Gum HE FUCOGEL HE, and its supplier is Xianting (Guangzhou) Trading Co., Ltd. It contains 1.1wt% Biosaccharide Gum-1, 1.7wt% 1,2-hexanediol, 0.1wt% ethylhexylglycerin, and the balance water. Its efficacy and product features are described as follows: 1. Fermentation-derived, containing L-fucose, D-galactose, and galacturonic acid; 2. Inhibits neurogenic inflammation through the ASIC signaling pathway, calming and soothing skin discomfort; 3. Promotes hyaluronic acid production for long-lasting moisturizing; 4. Activates the youth protein sirtuin-1 (acetylase-1), promotes collagen production, reduces wrinkles, and tightens the skin; 5. Activates epidermal renewal;

[0026] The trade name for Glyceryl Glucoside is SHINE+ Glyceryl Glucoside, and its supplier is Guangdong Xuanjia Medical Health Technology Co., Ltd. Its ingredients are: 65wt% Glyceryl Glucoside, 5wt% 1,2-pentanediol, and the balance water. Its efficacy and product features are listed as follows: 1. Fermentation-derived; 2. Promotes the expression of the skin's aquaporin AQP3, enhancing the skin's moisturizing ability; 3. Promotes the production of fibroblasts and collagen I, anti-wrinkle and firming; 4. Inhibits tyrosinase activity, whitening the skin; 5. Reduces skin redness and soothes sensitive symptoms.

[0027] Coenzyme Q10 is marketed under the trade name ALL-Q (COENZYME Q10) PLUS, supplied by DSM Nutritional Products Ltd. Its active ingredients are: 72.5 wt% C12-15 alkyl benzoate, 20 wt% tocopheryl acetate, and 7.5 wt% ubiquinone. Its efficacy and product features are described as follows: 1. An activator of cellular respiration and metabolism, essential for mitochondrial ATP synthesis; 2. Scavenging free radicals, reducing oxidative stress damage to collagen and elastic fibers, and delaying photoaging and natural aging; 3. Promoting collagen and elastin production, reducing wrinkles and firming the skin.

[0028] The coordination mechanism of the lactobacillus / soymilk fermentation product filtrate, biosaccharide gum-1, glycerol glucoside, coenzyme Q10 and caffeine composite components of the present invention is:

[0029] The comprehensive effects of the present invention are: revitalizing, reducing swelling, brightening, soothing, firming, and anti-aging;

[0030] The present invention achieves the above effects through the combined effects of the following aspects:

[0031] Step 1: Use coenzyme Q10 to activate cell energy and caffeine complex components to accelerate skin microcirculation and promote skin metabolism;

[0032] Step 2: Use caffeine complex components, especially caffeine inclusions and glyceryl glucoside to reduce swelling, remove dullness, balance water and oil, and brighten skin tone;

[0033] Step 3: Use Biosaccharide Gum-1 to activate youth proteins, eliminate free radicals, tighten the skin and reduce wrinkles;

[0034] Step 4: Use Lactobacillus / soy milk fermentation product filtrate to balance the skin microecology, strengthen the skin barrier, and soothe inflammation with Lactobacillus / soy milk fermentation product filtrate and Biosaccharide Gum-1.

[0035] Through the above four steps, the skin can be revitalized, de-swelled, brightened, soothed, tightened and anti-aging.

[0036] In the coffee-containing composition, the weight ratio of the lactobacillus / soymilk fermentation product filtrate, biosaccharide gum-1, glycerol glucoside, and coenzyme Q10 is 0.0001-5:0.0001-6:0.0001-4.9:0.0001-0.05.

[0037] The coffee-containing composition is composed of the following components in parts by weight:

[0038] Arabica coffee seed extract 0.006-0.045;

[0039] Caffeine inclusions 0.5-5;

[0040] Cocoa extract 0.05~0.5;

[0041] Lactobacillus / soy milk fermentation product filtrate 0.05~0.5;

[0042] Biosaccharide Gum-1 0.011~0.055;

[0043] Glyceryl glucoside 0.1~2.5;

[0044] Coenzyme Q10 0.001~0.05.

[0045] In addition, the present invention also discloses the use of any of the above coffee-containing compositions in preparing skin care products.

[0046] Finally, the present invention discloses a skin care product comprising any one of the above coffee-containing compositions.

[0047] Beneficial effects

[0048] Compared with the prior art, the present invention has at least the following advantages:

[0049] The composition combines three ingredients rich in caffeine and caffeine-like substances, namely, coffee arabica seed extract, caffeine inclusions, and cocoa extract, and is combined with auxiliary components to achieve very significant firming and anti-wrinkle effects.

[0050] Furthermore, the combination of three caffeine complex components containing caffeine and caffeine-like components and ingredients with soothing, barrier repair, anti-oxidation, and mitochondrial energy enhancement properties can shape the facial micro-shape while making the skin appear glossy and free of micro-wrinkles. DETAILED DESCRIPTION

[0051] The present invention will be further described below in conjunction with the embodiments, but this does not constitute any limitation to the present invention. Any limited modifications made within the scope of the claims of the present invention are still within the scope of the claims of the present invention.

[0052] Part 1 Preparation of Coffee-Containing Composition with Firming and Anti-Wrinkle Effects

[0053] Examples and Comparative Examples

[0054] The present invention is formulated according to the formulation described in Table 1 below. In the present invention, except for coenzyme Q10, all other raw materials are hydrophilic components. The commercial product corresponding to coenzyme Q10 contains a surfactant. Furthermore, the present invention also adds a solubility-promoting surfactant, PEG-40 hydrogenated castor oil, the amount of which is related to coenzyme Q10 and is approximately 26.5 times that of coenzyme Q10. Therefore, all raw materials can be relatively evenly distributed in the aqueous phase. Therefore, during the preparation process, the sample preparation can be completed by dispersing each component into the aqueous phase in the laboratory.

[0055] The components in Table 1 of the present invention are all represented by trade names, and the sources of the trade names can be found above;

[0056] Table 1 Formula weight parts

[0057]

[0058] Performance Testing

[0059] Free radical scavenging test

[0060] 1. Test Principle

[0061] Anti-wrinkle efficacy can be characterized by evaluating the test sample's inhibition rate against DPPH free radicals. The DPPH analysis method is a simple method for screening free radical scavengers and evaluating antioxidant activity. An ethanol solution of DPPH appears purple, with a maximum absorption wavelength of 517 nm. When a free radical scavenger is added to a DPPH solution, its lone pair electrons are paired, and absorption disappears or weakens, causing the solution to become lighter in color, appearing yellow or pale yellow, and the absorbance at 517 nm to decrease. The degree of change is linearly related to the free radical scavenging strength, allowing for quantitative analysis using a spectrophotometer. This method can be expressed as a scavenging rate; a higher scavenging rate indicates a stronger scavenging ability.

[0062] 2. Free radical scavenging test

[0063] Examples 1 to 4 and Comparative Examples 1 to 3 in Table 1 were used as samples, and the samples were diluted 50 times for testing.

[0064] 3. The test method is:

[0065] This in vitro test measures the free radical scavenging activity of DPPH, a stable free radical, and is suitable for evaluating cosmetic products and ingredients claiming to achieve anti-wrinkle effects through free radical scavenging. As a supplement to subjective and objective human evaluation methods, in vitro testing, as one of the in vivo antioxidant pathways, has a certain correlation with in vivo antioxidant efficacy testing results.

[0066] Through experimental design, DPPH free radical scavenging efficiency was compared between the test sample group and the blank group. Three replicates were measured at each gradient, and the scavenging efficiency was calculated and a linear equation was derived. Laboratory method (GDQT-SOP-165 Free Radical (DPPH) Scavenging Efficiency Test) was used.

[0067] The test report numbers are GQDT2025061487 to GQDT2025061493, and the testing unit is: Guangdong Product Quality Testing Co., Ltd.

[0068] The test results can be seen in Table 2;

[0069] Table 2 Test results

[0070] sample Linear equations Clearance Example 1 y=-0.0013x+0.9367 87.17％ Example 2 y=-0.0002x+0.896 88.60％ Example 3 y=-0.0035x+1.0285 85.35％ Example 4 y=-0.0043x+0.9578 74.28％ Comparative Example 1 y=-0.0079x+0.9894 59.44％ Comparative Example 2 y=-0.011x+0.9484 39.84％ Comparative Example 3 y=-0.0071x+0.5944 23.94％

[0071] According to the test results in Table 2 above, in the present invention, the Coffea arabica seed extract and the cocoa (Theobromacacao) extract play an important role in scavenging free radicals. Furthermore, the Coffea arabica seed extract plays a decisive role in the free radical scavenging ability.

[0072] Through the above experimental results, we can draw the following conclusions:

[0073] 1. The firming and anti-wrinkle levels were evaluated based on free radical scavenging ability. The concentration described in Example 3 was the optimal level for the formula, and increasing the concentration did not increase the free radical scavenging level.

[0074] 2. Arabica coffee seed extract, caffeine, and cocoa (THEOBROMACACAO) extract have a certain degree of synergy in free radical scavenging;

[0075] 3. In the present invention, although biosaccharide gum-1 and ubiquinone theoretically have certain free radical scavenging capabilities, given that their usage is relatively small, they have little effect on the free radical scavenging ability. Their main use is to participate in the process of skin free radical scavenging as one of the links directly acting on the skin or mainly activating related proteins and cells.

[0076] Firming and anti-wrinkle test

[0077] 30 volunteers aged between 25 and 45 years old, including 12 males and 18 females, were recruited and randomly divided into 6 groups. The compositions shown in Example 3, Comparative Example 1, Comparative Example 2, Comparative Example 3, Comparative Example 4, and Comparative Example 5 were prepared into facial mask liquids (the formula of the facial mask liquid can be referred to Table 4). The facial mask liquids were distributed to the volunteers in the form of facial masks, and the volunteers applied the facial masks once in the morning and evening. After one week (7 days), survey documents were distributed and the user experience was recorded.

[0078] The questions listed in the questionnaire are:

[0079] 1. After using the product for 7 days, do you feel that your skin elasticity has been significantly improved?

[0080] Options: Completely agree, Somewhat agree, Neither agree nor disagree, Somewhat disagree, Completely disagree

[0081] 2. After using the product for 7 days, do you feel that your skin firmness has been significantly improved?

[0082] Options: Completely agree, Somewhat agree, Neither agree nor disagree, Somewhat disagree, Completely disagree

[0083] 3. After using the product for 7 days, do you feel that your wrinkles (nasolabial folds, forehead wrinkles, and crow's feet) have been significantly improved?

[0084] Options: Completely agree, Somewhat agree, Neither agree nor disagree, Somewhat disagree, Completely disagree;

[0085] 4. While using the sample, please rate the burning sensation on your face.

[0086] The burning sensation was rated from 10 to 0 from strong to weak;

[0087] 5. Score the product's stickiness and freshness;

[0088] The product's stickiness and freshness are rated from 10 to 0 from strong to weak;

[0089] The statistical results of the questionnaire can be found in Table 3. The results in Table 3 are the average of the total evaluation scores of each group. In the first three scoring items, completely agree is 2 points, relatively agree is 1 point, neither agree nor disagree is 0 points, relatively disagree is -1 point, and completely disagree is -2 points.

[0090] Table 3 Statistical results

[0091]

[0092] Table 4 Facial mask formula

[0093]

[0094]

[0095] The above statistical results show that during the trial, volunteers all felt that the formula of the present invention significantly improved their skin's elasticity, firmness, and wrinkle resistance. During the testing of Comparative Examples 1-3, the relevant evaluation results were relatively low, indicating that the Arabica coffee (Coffea arabica) seed extract, caffeine, and Theobromacacao (Theobromacacao) extract in the formula of the present invention have significant effects on skin firming and wrinkle resistance.

[0096] According to the statistical results of Comparative Examples 4 and 5, both have a significant impact on the use effect of the formula. Among them, the lactobacillus / soy milk fermentation product filtrate has a significant soothing effect and can reduce the irritation of the product. In addition to its free radical scavenging effect, Biosaccharide Gum-1 also has a film-forming function, which can improve the effect of the active ingredients on the skin.

[0097] In summary, the composition of the present invention, which contains caffeine, a caffeine-like component, and a combination of ingredients with soothing, barrier-repairing, antioxidant, and mitochondrial energy-enhancing properties, can shape the facial micro-contour while allowing the skin to appear glossy and free of micro-wrinkles.

[0098] The embodiments presented herein are merely embodiments selected from a combination of all possible embodiments. The appended claims should not be limited by the embodiments describing the present invention. Some numerical ranges used in the claims include subranges therein, and variations in these ranges should also be covered by the appended claims.

Claims

1. A coffee-containing composition with firming and anti-wrinkle effects, characterized in that: It comprises a caffeine compound component and an auxiliary component; the auxiliary component has at least one function of soothing, barrier repairing, anti-oxidation, and improving mitochondrial energy; The caffeine composite component consists of Arabica coffee seed extract, caffeine inclusions, and cocoa extract; The caffeine inclusions are composed of cyclodextrin and caffeine; The weight ratio of the coffee arabica seed extract, the caffeine inclusions and the cocoa extract is 0.0001-3:0.01-6:0.0001-6.

2. The coffee-containing composition according to claim 1, characterized in that The auxiliary components consist of lactobacillus / soy milk fermentation product filtrate, biosaccharide gum-1, glycerol glucoside and coenzyme Q10.

3. The coffee-containing composition according to claim 2, characterized in that The weight ratio of the lactobacillus / soymilk fermentation product filtrate, biosaccharide gum-1, glycerol glucoside and coenzyme Q10 is 0.0001-5:0.0001-6:0.0001-4.9:0.0001-0.

05.

4. The coffee-containing composition according to claim 1, wherein It is composed of the following components in parts by weight: Arabica coffee seed extract 0.006-0.045; Caffeine inclusions 0.5-5; Cocoa extract 0.05~0.5; Lactobacillus / soy milk fermentation product filtrate 0.05~0.5; Biosaccharide Gum-1 0.011~0.055; Glyceryl glucoside 0.1~2.5; Coenzyme Q10 0.001~0.

05.

5. Use of the coffee-containing composition according to any one of claims 1 to 4 in preparing skin care products.

6. A skin care product, characterized in that: A coffee-containing composition according to any one of claims 1 to 5.

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