Traditional Chinese medicine composition for preventing and treating tumor cancer and resisting relapse

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating tumor cancer and resisting relapse, which comprises the following raw materials in parts by weight: 1-50 parts of sanqi, 1-50 parts of Chinese mahonia, 10-100 parts of gynostemma pentaphylla, 1-50 parts of wild poria cocos, 1-50 parts of local scorpion and 1-60 parts of wild gastrodia elata. The whole formula is synergistic, and the cachexia metabolic disorder is improved by adjusting the intestinal flora-immune axis; the traditional Chinese medicine composition integrates three treatment methods of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials and supporting healthy energy, eliminates evil without hurting healthy energy through multi-channel cross regulation and control, and provides a traditional Chinese medicine innovative scheme for tumor prevention and treatment.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating tumor cancer and preventing recurrence. Background Art

[0002] A tumor refers to a new growth formed by the proliferation of local tissue cells under the action of various tumorigenic factors. Because this new growth is mostly a space-occupying mass-like protrusion, it is also called a growth. Tumor cells will undergo metabolic changes different from normal cells. At the same time, tumor cells themselves can adapt to changes in the metabolic environment by switching between glycolysis and oxidative phosphorylation.

[0003] Existing treatments for tumors are mostly surgical resection, but surgery can easily cause damage to normal human tissues, and the patient's recovery time is long, which increases the patient's pain.

[0004] In view of this, the inventors hope to provide a Chinese medicine composition for preventing and treating tumor cancer and preventing recurrence. Summary of the Invention

[0005] The purpose of the present invention is to overcome the above-mentioned problems existing in traditional technologies and provide a Chinese medicine composition for preventing and treating tumor cancer and preventing recurrence.

[0006] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0007] The invention provides a traditional Chinese medicine composition for preventing, treating and resisting the recurrence of tumor cancer. The composition comprises the following raw materials in parts by weight: 1-50 parts of Sanqi, 1-50 parts of Mahonia, 10-100 parts of Gynostemma pentaphyllum, 1-50 parts of Poria cocos, 1-50 parts of Bullscorpion, and 1-60 parts of Gastrodia elata.

[0008] Furthermore, the Chinese medicine composition as described above comprises the following raw materials in parts by weight: 20-40 parts of Sanqi, 20-40 parts of Mahonia, 30-40 parts of Gynostemma pentaphyllum, 10-20 parts of Poria cocos, 10-20 parts of Achyranthes bidentata, and 15-30 parts of Gastrodia elata.

[0009] Furthermore, the Chinese medicine composition as described above comprises the following raw materials in parts by weight: 25 parts of Sanqi, 35 parts of Mahonia, 32 parts of Gynostemma pentaphyllum, 18 parts of Poria cocos, 12 parts of Achyranthes bidentata, and 18 parts of Gastrodia elata.

[0010] Furthermore, the Chinese medicine composition as described above comprises the following raw materials in parts by weight: 35 parts of Sanqi, 25 parts of Mahonia, 38 parts of Gynostemma pentaphyllum, 15 parts of Poria cocos, 18 parts of Achyranthes bidentata, and 25 parts of Gastrodia elata.

[0011] Furthermore, the preparation method of the above-mentioned Chinese medicine composition comprises the following steps:

[0012] S1. Raw material pretreatment and preparation;

[0013] S2, active ingredient extraction;

[0014] S3. Preparation molding.

[0015] Furthermore, the specific operations of step S1 are as follows:

[0016] Sanqi: Wash and slice fresh product into slices with a thickness of 2-3 mm; dry at 60°C until the moisture content is ≤8%.

[0017] Take the stem, scrape off the outer layer of bark, keep the yellow wood, cut into 1-2mm thin slices, dry in the sun, and then crush through a 60-mesh sieve;

[0018] Gynostemma pentaphyllum: Wash the entire plant, freeze-dry at 50°C to preserve heat-sensitive components, with a saponin retention rate >98%; then grind into ultrafine powder with a particle size of ≤15 μm.

[0019] Wild Poria cocos, wild bull scorpion, and wild Gastrodia elata: Wash them separately, dry them at 55℃ for 6 hours until the moisture content is ≤10%, mix them, and then grind them through a 40-mesh sieve.

[0020] Furthermore, the specific operations of step S2 are as follows:

[0021] 1) Extraction solvent: 80% ethanol-water solution with a solid-liquid ratio of 1:15;

[0022] 2) First decoction: Mix the herbs with the solvent, reflux at 80°C for 2 hours, and filter the filtrate.

[0023] 3) Second decoction: Add 6 times the amount of 80% ethanol to the medicinal residue relative to the medicinal material, reflux at 70°C for 1.5 hours, and combine the filtrates;

[0024] 4) Concentration: The combined filtrates were concentrated under reduced pressure at 60°C and -0.08 MPa to an extract with a density of 1.15-1.20 g / ml.

[0025] Furthermore, the specific operations of step S3 are as follows:

[0026] 1) Mixing and granulation: The extract is mixed with ultrafinely ground Gynostemma pentaphyllum powder and Mahonia lactiflora powder in proportion, and 10% of the weight of the extract is added as a binder of starch. After preparing a soft material, the mixture is passed through an 18-mesh sieve and granulated;

[0027] 2) Drying process: The granules are placed in a fluidized bed and dried with hot air at 45°C until the moisture content is ≤5%.

[0028] 3) Packaging: Fill the granules into capsules, each granule contains 0.5g of crude drug; or compress into tablets, each tablet contains 0.4g.

[0029] The core effects and anti-tumor mechanisms of the raw materials of the present invention are as follows:

[0030] 1. Sanqi

[0031] Effect: Direct anti-tumor effect: Contains flavonoids and phenolic acids such as quercetin and gallic acid, which can induce tumor cell apoptosis and inhibit the proliferation of liver cancer and gastric cancer cells.

[0032] Synergistic effect: promoting blood circulation and removing blood stasis improves tumor microcirculation and enhances the permeability of other drugs; cooling blood and stopping bleeding reduce the risk of tumor rupture and bleeding.

[0033] Key mechanism: Blocking the STAT3 signaling pathway, inhibiting tumor cell survival; scavenging free radicals through antioxidant activity, preventing carcinogenesis caused by DNA damage.

[0034] 2. Ten major achievements

[0035] Effect: Immune regulation; alkaloids such as berberine and jatrorrhizine activate macrophages and NK cells, enhancing immune surveillance function.

[0036] Anti-cancer auxiliary: inhibit carcinogenic pathogens such as Staphylococcus aureus and reduce the risk of infection-related tumors.

[0037] Key mechanism: Downregulates VEGF expression, blocks tumor angiogenesis, and induces G0 / G1 cell cycle arrest in liver cancer cells.

[0038] 3. Gynostemma pentaphyllum

[0039] Effect: Multi-target anti-tumor; saponins (such as GP-L) target the SREBP2 / HMGCS1 pathway and inhibit cholesterol metabolism in liver cancer cells.

[0040] Reducing toxicity and increasing efficacy: Alleviating chemotherapy-induced bone marrow suppression and improving patient tolerance.

[0041] Key mechanism: Activates the caspase-3 / 9 pro-apoptotic pathway; inhibits epithelial-mesenchymal transition (EMT), and blocks the metastasis of lung cancer and breast cancer.

[0042] 4. Wild Poria cocos

[0043] Effect: Metabolic regulation; Poria polysaccharide reverses tumor multidrug resistance and enhances the sensitivity of chemotherapy drugs such as cisplatin.

[0044] Inhibit metastasis: Pachymic acid reduces microvessel density and inhibits tumor angiogenesis.

[0045] Key mechanism: Regulates Treg / Th17 immune balance and improves tumor immunosuppressive microenvironment.

[0046] 5. Earth Bull Scorpion

[0047] Effect: Scorpion venom peptides from the soil inhibit the NF-κB pathway and block the cancer-promoting effects of inflammatory factors.

[0048] 6. Wild Gastrodia elata

[0049] Effect: Gastrodin regulates the BDNF / TrkB pathway, alleviating cancer pain and chemotherapy neurotoxicity.

[0050] The beneficial effects of the present invention are:

[0051] 1. Multi-target synergistic inhibition of tumor proliferation

[0052] Sanqi + Gynostemma pentaphyllum: Quercetin and saponins synergistically downregulate Bcl-2 protein and enhance the apoptosis sensitivity of tumor cells;

[0053] Euonymus japonicus + Poria cocos: Alkaloids and polysaccharides jointly inhibit the PI3K / Akt pathway and block abnormal cell proliferation.

[0054] 2. Remodeling of the immune microenvironment

[0055] Gynostemma pentaphyllum + ten major benefits: saponins activate DC cell antigen presentation, berberine promotes T cell infiltration and reverses immune escape;

[0056] Wild Poria cocos + Wild Gastrodia elata: Regulate the hypothalamic-pituitary-adrenal axis and reduce the suppression of immune function caused by stress response.

[0057] 3. Anti-metastasis and vascular normalization

[0058] Sanqi + Poria cocos: Quercetin inhibits MMP-9 expression, and pachymic acid blocks VEGFR2 phosphorylation, doubly inhibiting metastasis formation;

[0059] Bull scorpion: Scorpion venom peptide targets integrin αvβ3, inhibiting tumor cell adhesion and invasion.

[0060] 4. Metabolic reprogramming and attenuation

[0061] Gynostemma pentaphyllum + wild Gastrodia elata: Saponins repair liver cell mitochondrial function, while gastrodin protects neurons and reduces treatment toxicity;

[0062] 5. Comprehensive synergy: Improve cachexia metabolic disorders (such as lactic acid accumulation and fat decomposition) by regulating the intestinal flora-immune axis.

[0063] 6. The Chinese medicine composition of the present invention integrates three treatment methods: promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and strengthening the body's resistance. Through multi-pathway cross-regulation, it achieves "eliminating evil without harming the body's resistance", providing an innovative Chinese medicine solution for tumor prevention and treatment.

[0064] Of course, any product implementing the present invention does not necessarily need to achieve all of the above advantages at the same time. DETAILED DESCRIPTION

[0065] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0066] The relevant specific embodiments of the present invention are as follows:

[0067] Example 1

[0068] This embodiment provides a traditional Chinese medicine composition for preventing and treating tumor cancer and preventing recurrence, comprising the following raw materials in parts by weight: 25 parts of Sanqi, 35 parts of Mahonia, 32 parts of Gynostemma pentaphyllum, 18 parts of Poria cocos, 12 parts of Niushi, and 18 parts of Gastrodia elata.

[0069] The preparation method comprises the following steps:

[0070] S1. Raw material pretreatment and preparation

[0071] Sanqi: Wash and slice fresh product into slices with a thickness of 2-3 mm; dry at 60°C until the moisture content is ≤8%.

[0072] Take the stem, scrape off the outer layer of bark, keep the yellow wood, cut into 1-2mm thin slices, dry in the sun, and then crush through a 60-mesh sieve;

[0073] Gynostemma pentaphyllum: Wash the entire plant, freeze-dry at 50°C to preserve heat-sensitive components, with a saponin retention rate of >98%; then grind into ultrafine powder with a particle size of ≤15 μm.

[0074] Wild Poria cocos, wild bull scorpion, and wild Gastrodia elata: Wash them separately, dry them at 55℃ for 6 hours until the moisture content is ≤10%, mix them, and then grind them through a 40-mesh sieve.

[0075] S2. Active ingredient extraction

[0076] 1) Extraction solvent: 80% ethanol-water solution with a solid-liquid ratio of 1:15;

[0077] 2) First decoction: Mix the herbs with the solvent, reflux at 80°C for 2 hours, and filter the filtrate.

[0078] 3) Second decoction: Add 6 times the amount of 80% ethanol to the medicinal residue relative to the medicinal material, reflux at 70°C for 1.5 hours, and combine the filtrates;

[0079] 4) Concentration: The combined filtrates were concentrated under reduced pressure at 60°C and -0.08 MPa to an extract with a density of 1.15-1.20 g / ml.

[0080] S3, Preparation Forming

[0081] 1) Mixing and granulation: The extract is mixed with ultrafinely ground Gynostemma pentaphyllum powder and Mahonia lactiflora powder in proportion, and 10% of the weight of the extract is added as a binder of starch. After preparing a soft material, the mixture is passed through an 18-mesh sieve and granulated;

[0082] 2) Drying process: The granules are placed in a fluidized bed and dried with hot air at 45°C until the moisture content is ≤5%.

[0083] 3) Packaging: Fill the granules into capsules, each capsule contains 0.5g of crude drug.

[0084] Example 2

[0085] This embodiment provides a traditional Chinese medicine composition for preventing and treating tumor cancer and preventing recurrence, comprising the following raw materials in parts by weight: 35 parts of Sanqi, 25 parts of Mahonia, 38 parts of Gynostemma pentaphyllum, 15 parts of Poria cocos, 18 parts of Niushi, and 25 parts of Gastrodia elata.

[0086] The preparation method comprises the following steps:

[0087] S1. Raw material pretreatment and preparation

[0088] Sanqi: Wash and slice fresh product into slices with a thickness of 2-3 mm; dry at 60°C until the moisture content is ≤8%.

[0089] Take the stem, scrape off the outer layer of bark, keep the yellow wood, cut into 1-2mm thin slices, dry in the sun, and then crush through a 60-mesh sieve;

[0090] Gynostemma pentaphyllum: Wash the entire plant, freeze-dry at 50°C to preserve heat-sensitive components, with a saponin retention rate >98%; then grind into ultrafine powder with a particle size of ≤15 μm.

[0091] Wild Poria cocos, wild bull scorpion, and wild Gastrodia elata: Wash them separately, dry them at 55℃ for 6 hours until the moisture content is ≤10%, mix them, and then grind them through a 40-mesh sieve.

[0092] S2. Active ingredient extraction

[0093] 1) Extraction solvent: 80% ethanol-water solution with a solid-liquid ratio of 1:15;

[0094] 2) First decoction: Mix the herbs with the solvent, reflux at 80°C for 2 hours, and filter the filtrate.

[0095] 3) Second decoction: Add 6 times the amount of 80% ethanol to the medicinal residue relative to the medicinal material, reflux at 70°C for 1.5 hours, and combine the filtrates;

[0096] 4) Concentration: The combined filtrates were concentrated under reduced pressure at 60°C and -0.08 MPa to an extract with a density of 1.15-1.20 g / ml.

[0097] S3. Formulation

[0098] 1) Mixing and granulation: The extract is mixed with ultrafinely ground Gynostemma pentaphyllum powder and Mahonia lactiflora powder in proportion, and starch (10% by weight of the extract) is added as a binder. After preparing a soft material, the mixture is passed through an 18-mesh sieve and granulated;

[0099] 2) Drying process: The granules are placed in a fluidized bed and dried with hot air at 45°C until the moisture content is ≤5%.

[0100] 3) Packaging: Compress the granules into tablets, 0.4 g each.

[0101] Example 3

[0102] This embodiment provides a traditional Chinese medicine composition for preventing and treating tumor cancer recurrence, comprising the following raw materials in parts by weight: 30 parts of Sanqi, 30 parts of Mahonia, 32 parts of Gynostemma pentaphyllum, 18 parts of wild Poria, 12 parts of Achyranthes bidentata, and 18 parts of wild Gastrodia.

[0103] The preparation method comprises the following steps:

[0104] S1. Raw material pretreatment and preparation

[0105] Sanqi: Wash and slice fresh product into slices with a thickness of 2-3 mm; dry at 60°C until the moisture content is ≤8%.

[0106] Take the stem, scrape off the outer layer of bark, keep the yellow wood, cut into 1-2mm thin slices, dry in the sun, and then crush through a 60-mesh sieve;

[0107] Gynostemma pentaphyllum: Wash the entire plant, freeze-dry at 50°C to preserve heat-sensitive components, with a saponin retention rate of >98%; then grind into ultrafine powder with a particle size of ≤15 μm.

[0108] Wild Poria cocos, wild bull scorpion, and wild Gastrodia elata: Wash them separately, dry them at 55℃ for 6 hours until the moisture content is ≤10%, mix them, and then grind them through a 40-mesh sieve.

[0109] S2. Active ingredient extraction

[0110] 1) Extraction solvent: 80% ethanol-water solution with a solid-liquid ratio of 1:15;

[0111] 2) First decoction: Mix the herbs with the solvent, reflux at 80°C for 2 hours, and filter the filtrate.

[0112] 3) Second decoction: Add 6 times the amount of 80% ethanol to the medicinal residue relative to the medicinal material, reflux at 70°C for 1.5 hours, and combine the filtrates;

[0113] 4) Concentration: The combined filtrates were concentrated under reduced pressure at 60°C and -0.08 MPa to an extract with a density of 1.15-1.20 g / ml.

[0114] S3, Preparation Forming

[0115] 1) Mixing and granulation: The extract is mixed with ultrafinely ground Gynostemma pentaphyllum powder and Mahonia lactiflora powder in proportion, and starch (10% by weight of the extract) is added as a binder. After preparing a soft material, the mixture is passed through an 18-mesh sieve and granulated;

[0116] 2) Drying process: The granules are placed in a fluidized bed and dried with hot air at 45°C until the moisture content is ≤5%.

[0117] 3) Packaging: Fill the granules into capsules, each capsule contains 0.5g of crude drug.

[0118] The Chinese medicine composition provided in Example 1 is used as a therapeutic drug, and the relevant specific cases are as follows:

[0119] Case 1: Mr. Tu, male, 67 years old. In 2010, he went to the hospital due to headaches and dizziness and was diagnosed with a brain tumor. He recovered after 6 months of treatment with traditional Chinese medicine and has not had a relapse since then. Everything is normal.

[0120] Case 2: Yang, a 23-year-old male, suffered from frequent headaches in January 2008 and was diagnosed with a brain tumor at Hospital A. He remained hospitalized for several months with no improvement. He was discharged in May 2008 and rested at home, but continued to experience frequent headaches and dizziness. In 2009, his father, through a referral, began taking anti-cancer Chinese medicine from the Huaihua Tu Ri Chinese Medicine Hospital Research Institute, three pills three times daily. After three months of treatment, his headaches and dizziness disappeared. Six months later, he returned to Huaihua Chinese Medicine Hospital for a checkup, confirming the cancer had disappeared. He has not had a relapse since stopping the medicine and continues to work away from home, all normal.

[0121] Case 3: Mr. Yang, a 47-year-old male, presented with chest pain in March 2010 to Hospital A for a checkup. He was diagnosed with a cardiac hemangioma and was hospitalized for over ten days. Due to the rapid growth of the tumor, he was transferred to Hospital B. Similarly, due to the rapid growth of the cardiac hemangioma, he returned to the hospital for emergency treatment. The attending physician recommended surgery, which would have cost 400,000 yuan. Due to the high cost, the patient forgoed surgery. He then received a recommendation for anti-cancer Chinese medicine treatment from the Tu Ri Zhong Hospital Research Institute, taking six pills three times daily. After several courses of treatment, he felt significantly better. A further examination at the hospital confirmed that the tumor had shrunk. He discontinued the medication after several courses. Since then, he has had no recurrence and is doing well.

[0122] Case 4: Ms. Wu, a 60-year-old woman, was diagnosed with breast cancer at Hospital A in 2018. She underwent mastectomy and treatment, but the cancer recurred six months after her discharge. She was then referred to an anti-cancer Chinese medicine clinic at the Huaihua Tu Ri Chinese Medicine Hospital Research Institute and recovered after three months of treatment. She has had no recurrence to date and is doing well.

[0123] Case 5: Tu, a 72-year-old male, presented to Hospital A in October 2018 with swollen feet. The cause remained unknown, but the swelling worsened. He subsequently took anti-cancer Chinese medicine from the Huaihua Tu Ri Chinese Medicine Hospital Research Institute for two months, taking six pills three times daily. Over a month later, the swelling disappeared. Since then, he has been healthy and has not recurred.

[0124] Case 6: Yang, male, 45 years old. In October 2016, he developed a tumor on his skin that caused frequent itching and pain. He subsequently took traditional Chinese medicine from the Huaihua Tu Ri Chinese Medicine Hospital Research Institute, taking six pills three times a day. He recovered after three months of treatment and has not had a relapse since then, with all symptoms normal.

[0125] Case 7: Tu, male, 67 years old. He developed swelling and erosion in his lower limbs and feet in 2016. He took anti-cancer Chinese medicine from the Huaihua Tu Ri Chinese Medicine Hospital Research Institute and recovered after three months of treatment. He has not had any recurrence to date and is now back to normal.

[0126] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to specific embodiments. Obviously, many modifications and variations are possible based on the contents of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A Chinese medicine composition for preventing and treating tumor cancer recurrence, characterized in that: The invention comprises the following raw materials in parts by weight: 1-50 parts of Sanqi, 1-50 parts of Mahonia, 10-100 parts of Gynostemma pentaphyllum, 1-50 parts of Poria cocos, 1-50 parts of Bull Scorpion, and 1-60 parts of Gastrodia elata.

2. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 20-40 parts of Sanqi, 20-40 parts of Mahonia, 30-40 parts of Gynostemma pentaphyllum, 10-20 parts of wild Poria, 10-20 parts of Achyranthes bidentata and 15-30 parts of wild Gastrodia elata.

3. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 25 parts of Sanqi, 35 parts of Mahonia, 32 parts of Gynostemma pentaphyllum, 18 parts of wild Poria, 12 parts of Achyranthes bidentata and 18 parts of wild Gastrodia.

4. The Chinese medicine composition according to claim 1, characterized in that The invention comprises the following raw materials in parts by weight: 35 parts of Radix Notoginseng, 25 parts of Mahoniae Ophiopogonis, 38 parts of Gynostemma Pentaphyllum, 15 parts of Poria Cocos, 18 parts of Bull Scorpion and 25 parts of Gastrodia elata.

5. The Chinese medicine composition according to any one of claims 1 to 4, characterized in that The preparation method comprises the following steps: S1. Raw material pretreatment and preparation; S2, active ingredient extraction; S3. Preparation molding.

6. The Chinese medicine composition according to claim 5, characterized in that The specific operations of step S1 are as follows: Sanqi: Wash and slice fresh product into slices with a thickness of 2-3 mm; dry at 60°C until the moisture content is ≤8%. Take the stem, scrape off the outer layer of bark, keep the yellow wood, cut into 1-2mm thin slices, dry in the sun, and then crush through a 60-mesh sieve; Gynostemma pentaphyllum: Wash the entire plant, freeze-dry at 50°C to preserve heat-sensitive components, with a saponin retention rate of >98%; then grind into ultrafine powder with a particle size of ≤15 μm. Wild Poria cocos, wild bull scorpion, and wild Gastrodia elata: Wash them separately, dry them at 55℃ for 6 hours until the moisture content is ≤10%, mix them, and then grind them through a 40-mesh sieve.

7. The Chinese medicine composition according to claim 5, characterized in that The specific operations of step S2 are as follows: 1) Extraction solvent: 80% ethanol-water solution with a solid-liquid ratio of 1:15; 2) First decoction: Mix the herbs with the solvent, reflux at 80°C for 2 hours, and filter the filtrate. 3) Second decoction: Add 6 times the amount of 80% ethanol to the medicinal residue relative to the medicinal material, reflux at 70°C for 1.5 hours, and combine the filtrates; 4) Concentration: The combined filtrates were concentrated under reduced pressure at 60°C and -0.08 MPa to an extract with a density of 1.15-1.20 g / ml.

8. The Chinese medicine composition according to claim 5, characterized in that The specific operations of step S3 are as follows: 1) Mixing and granulation: The extract is mixed with ultrafinely ground Gynostemma pentaphyllum powder and Mahonia lactiflora powder in proportion, and starch (10% by weight of the extract) is added as a binder. After preparing a soft material, the mixture is passed through an 18-mesh sieve and granulated; 2) Drying process: The granules are placed in a fluidized bed and dried with hot air at 45°C until the moisture content is ≤5%. 3) Packaging: Fill the granules into capsules, each granule contains 0.5g of crude drug; or compress into tablets, each tablet contains 0.4g.