Centrifugal system adaptive to bottom extraction

Abstract

The invention discloses a centrifugal system adaptive to bottom extraction, and relates to the technical field of solid-liquid separation, and the centrifugal system adaptive to bottom extraction is characterized by comprising a centrifugal machine main body, a rotating drum is arranged in the centrifugal machine main body, and a bottom extraction device is arranged at the bottom of the rotating drum; the dynamic sealing structure is arranged between the bottom extraction device and the rotary drum and used for keeping the sealing performance in the centrifugal process and preventing material leakage; the modular interface is connected with the bottom extraction device and the material collection container, so that quick replacement and adaptation to components of different specifications are facilitated; and the automatic control system comprises a sensor module, a PLC (Programmable Logic Controller) and a remote monitoring module, and is used for monitoring parameters including the rotating speed, the temperature and the pressure in the centrifugal process in real time and realizing automatic control.

Description

Technical Field

[0001] The invention relates to the technical field of solid-liquid separation, and in particular to a centrifugal system adapted for bottom extraction. Background Art

[0002] Centrifugal systems are closely linked to the modern demands of biological sample processing, pharmaceutical manufacturing, and medical waste management in the medical field. Centrifugal force is often required to separate liquids and solid particles in applications such as traditional Chinese medicine extraction, biological sample processing (such as DNA isolation), and food processing. For example, impurities must be removed from traditional Chinese medicine extracts, and precipitates such as DNA or cell fragments after laboratory centrifugation must be efficiently collected.

[0003] Liquid discharge in traditional centrifugal systems mostly relies on gravity or top pouring, but the extraction of bottom sediment often leads to residue due to unreasonable structural design. For example, the sediment at the bottom of the centrifuge tube is difficult to completely extract due to the small diameter, or the sediment is brought out when the supernatant is poured out; some systems use a fixed bottom liquid outlet, which cannot adapt to liquids of different viscosities or particle sizes, is prone to clogging, and lacks a dynamic sealing design, which may cause liquid leakage or secondary contamination during extraction; existing technologies mostly rely on manual operations, such as manually disassembling the bottom of the tube and adjusting valves, which are inefficient and prone to introducing errors. Summary of the Invention

[0004] The present invention addresses the technical problems existing in the prior art. The bottom extraction device is used to efficiently extract the centrifuged material from the bottom of the drum, thereby reducing residue, improving separation efficiency, facilitating cleaning, and reducing labor intensity of workers. A partition structure is provided inside the drum, and its surface has micropores, which allow liquid to exchange under the action of centrifugal force while preventing solid particles from passing through, thereby improving the separation effect. The dynamic sealing structure adopts porous materials and T-slot design, which can maintain good sealing performance under high-speed rotation and high-temperature environments, and effectively prevent material leakage. The modular interface adopts a standardized design, supports quick connection and disassembly, facilitates rapid replacement and adaptation of components, and improves the flexibility and maintenance efficiency of the equipment. The automatic control system monitors the parameters of the centrifugal process in real time through the sensor module, PLC controller and remote monitoring module, and realizes automatic control, reducing manual intervention and improving the stability and safety of equipment operation. The remote monitoring module can collect the operating data of the equipment in real time and transmit it to the host computer through the remote communication protocol to realize remote monitoring and fault warning, thereby improving the reliability and operation efficiency of the equipment.

[0005] The present invention solves the above technical problems with the following technical solutions: A centrifugal system adapted for bottom extraction, comprising: The centrifuge body has a rotating drum inside and a bottom extraction device at the bottom of the drum; Dynamic sealing structure, which is set between the bottom extraction device and the drum, is used to maintain the sealing performance during the centrifugal process to prevent material leakage; Modular interface, which connects the bottom extraction device and the material collection container, facilitates quick replacement and adaptation of components of different specifications; The automated control system includes a sensor module, a PLC controller, and a remote monitoring module, which are used to monitor parameters during the centrifugation process, including speed, temperature, and pressure, in real time and achieve automated control.

[0006] Preferably, the centrifuge body specifically includes: A supporting structure, which is used to fix and support the drum and includes a sturdy frame and shock-absorbing mounts; A driving mechanism, which is used to drive the drum to rotate, including a motor and a transmission device; The drum is equipped with a partition structure and a wear-resistant coating inside, which is used to contain and separate materials. The inner wall is provided with a wear-resistant coating, and the partition structure is a detachable filter assembly with micropores on the surface, which allows liquid to be exchanged under the action of centrifugal force while preventing solid particles from passing through; The bottom extraction device includes an extraction pipe, a driving mechanism and a material sensor; one end of the extraction pipe is connected to the material collection container, and the other end can be sealably connected to the discharge port at the bottom of the drum; the driving mechanism is used to control the extension and contraction of the extraction pipe, and includes a motor and a transmission device; the material sensor is arranged in the extraction pipe to detect the properties and flow of the material; the heating wire is arranged on the outer wall of the extraction pipe to prevent the material from condensing and clogging during the extraction process.

[0007] Preferably, the dynamic sealing structure specifically includes: The dynamic sealing structure adopts porous materials, and its microporous structure is used to store lubricating media and realize self-circulation under the siphon and pumping action of the small hole flow channel; A T-slot is engraved on the outer diameter side of the sealing ring, half of which is porous and half is solid. The segmented porous T-slot mechanical seal structure creates a low-pressure area on the upwind side of the T-slot, introducing the sealing medium into the sealing gap through cavitation suction, increasing the liquid film opening force and enhancing lubrication.

[0008] Preferably, the modular interface specifically includes: The modular interface adopts standardized mechanical and electrical interface design to transmit control signals and monitoring data; The interface is equipped with quick connectors, allowing for quick assembly and disassembly of components without the use of tools; The interface is equipped with seals to ensure the sealing of the connection and prevent material leakage; A wide variety of adapters and conversion connectors are available to accommodate different sizes and types of components.

[0009] Preferably, the automated control system specifically includes: Sensor module: including speed sensor, temperature sensor, pressure sensor, material sensor; The speed sensor is used to monitor the speed of the centrifuge in real time to ensure that it operates within the set range; Temperature sensors are used to monitor temperature changes during centrifugation to prevent overheating that may cause material damage and equipment failure. The pressure sensor is used to monitor the pressure changes during the centrifugation process to ensure that the system operates at a safe pressure; Material sensors are used to detect the properties of the material in order to optimize the centrifugation parameters.

[0010] Preferably, the application of the sensor module specifically includes: Speed ​​sensor: Use photoelectric speed sensor and magnetoelectric speed sensor, installed on the main shaft and motor of the centrifuge, convert the speed signal into an electrical signal, and transmit it to the PLC controller for processing; Temperature sensor: Use thermocouples and thermal resistors, installed inside the drum and on the centrifuge casing. Regular calibration is required to ensure measurement accuracy, and software compensation algorithms are used to reduce the impact of ambient temperature. Connect to the PLC through an analog input interface, and the PLC will perform overheat protection and parameter adjustments based on temperature data. Pressure sensor: Piezoresistive pressure sensor and capacitive pressure sensor are usually installed at the feed port, discharge port and inside the drum of the centrifuge to convert the pressure signal into an electrical signal and transmit it to the PLC controller for processing; Material sensor: Infrared sensor, capacitive sensor, ultrasonic sensor are installed inside the drum and near the bottom extraction device. The material properties, including viscosity and density, are determined by detecting the reflection, capacitance change, and ultrasonic reflection of the material. The detected material property data is transmitted to the PLC, which optimizes the centrifugal parameters based on the data.

[0011] Preferably, the automated control system specifically includes: The PLC controller has logic control function, signal acquisition function, data processing function, timing and counting function, output control function, remote input and output function, and human-machine interface function; Logic control function: Use PLC's AND, OR, and NOT commands to replace the series and parallel logic connections of relay contacts to achieve logic control, switch control, and sequence control; Signal acquisition function: collect analog signals, digital signals and pulse signals; Data processing function: PLC is used for data transmission, data comparison, data conversion, data shift, and arithmetic operations; Timing and counting function: realize execution timing and delay control. The time is set by the user and can be changed as needed.

[0012] Preferably, the PLC controller specifically includes: Output control function: output digital signals, analog signals and pulse signals to control external solenoid valves and indicator light equipment; Remote input and output function: Remote I / O function means that the remote I / O unit connects various input and output devices scattered at a long distance with the main controller, receives and processes signals, and realizes remote control; Human-machine interface function: realize human-machine interaction, monitor equipment operation status, alarm and status display and process control, realize parameter setting and online configuration; Fault self-diagnosis function: self-check the system, find and report faults in time; The system health status detection in the fault self-diagnosis function includes:

[0013] Where FaultCode is the fault code, which is used to identify the specific fault detected in the system; Errortype is the error type, which indicates the category or nature of the fault; n is the number of bits in the error type code; and Errorlocation is the error location, which indicates the specific location or module where the fault occurred.

[0014] Preferably, the automated control system specifically includes: Remote monitoring module: including real-time monitoring function, remote data acquisition, data processing and analysis, equipment failure alarm, remote control and operation, historical data storage and query, user interface and data query; Real-time monitoring function: through the communication protocol, real-time collection of equipment operating data, including temperature, pressure, and speed; Remote data acquisition: remote communication with field equipment is achieved through communication protocols; Data processing and analysis: Real-time processing and analysis of collected data, including data cleaning, filtering, and trend analysis; Equipment failure alarm: When the equipment data exceeds the preset range, the system can automatically alarm and notify the operator through sound, light, and text messages; Remote control and operation: remotely control the equipment through the host computer software, modify equipment parameters, start and stop equipment operations; Historical data storage and query: supports the storage, query and export of equipment data, helping production personnel analyze historical data and optimize equipment operation; User interface and data query: Displays the operating status of the device through a graphical interface, and supports data query and report export.

[0015] Preferably, the data processing and analysis specifically include: Data cleaning: Identify and process outliers through statistical analysis and machine learning algorithms; convert data from different sources into a unified format to ensure data consistency; use interpolation and predictive models to fill missing values; identify and delete duplicate data records to improve data processing efficiency; Data filtering: The pass filter is used to remove high-frequency noise and retain low-frequency signals, and is suitable for smoothing speed and pressure data; the bandpass filter is used to extract signals within a specific frequency range, and is suitable for fine analysis of temperature and pressure data; the adaptive filter dynamically adjusts the filter parameters according to the data characteristics to adapt to different working conditions; Trend analysis: Using the moving average method to identify trends by calculating the moving average of data is suitable for short-term trend analysis; using the exponential smoothing method to assign higher weights to recent data points is suitable for medium- and long-term trend analysis; using the ARIMA model, the autoregressive integrated moving average model, is used for trend prediction of time series data; using wavelet analysis to decompose signals through wavelet transform and identify trends and characteristics at different time scales; Real-time processing and analysis: Use a stream processing framework to process real-time data to ensure low-latency responses; perform preliminary processing near the data source to reduce data transmission volume and improve processing efficiency; use a distributed computing framework to process large-scale data sets and increase processing speed; The trend analysis in the data processing analysis includes:

[0016] Where Y is the dependent variable, that is, the variable you want to predict or explain; X is the independent variable, that is, the variable used to predict or explain the dependent variable; a is the slope of the regression line, which represents the expected change in the dependent variable Y for each unit change in the independent variable X; b is the intercept of the regression line, which represents the expected value of the dependent variable Y when the independent variable X is 0; and n is the total number of data points.

[0017] The beneficial effects of the present invention are as follows: the bottom extraction device can efficiently extract the centrifuged material from the bottom of the drum, reduce the residual material in the drum, and improve the separation efficiency and extraction rate of the material; the dynamic sealing structure ensures that during high-speed centrifugation, the material will not leak from the gap between the bottom extraction device and the drum, thereby ensuring the integrity of the material and the sealing of the system, and avoiding material loss and environmental pollution; the modular interface facilitates rapid replacement and adaptation of components of different specifications, so that the system can flexibly respond to different types of materials and process requirements, improve the versatility and adaptability of the equipment, and reduce the maintenance cost and time of the equipment; the automated control system monitors the key parameters of the centrifugation process in real time, and performs automated control and adjustment based on these data to ensure the stability and consistency of the centrifugation process, reducing the risk of manual intervention and operational errors; it allows operators to monitor the operating status of the equipment in real time at a place far away from the equipment, promptly discover and handle abnormal situations, and improve the reliability and safety of the equipment operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A diagram showing the structure of a centrifugal system adapted for bottom extraction provided in an embodiment of the present invention; Figure 2 A diagram showing the structure of a sensor module provided in an embodiment of the present invention; Figure 3 A diagram showing the structure of a PLC controller provided in an embodiment of the present invention; Figure 4 This is a diagram of the remote monitoring module provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without making creative efforts are within the scope of protection of this application.

[0020] In the description of this application, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include one or more of the described features. In the description of this application, "plurality" means two or more, unless otherwise specifically specified.

[0021] In the description of this application, the term "for example" is used to mean "used as an example, illustration or explanation". Any embodiment described as "for example" in this application is not necessarily to be construed as being more preferred or advantageous than other embodiments. The following description is given to enable any person skilled in the art to implement and use the present invention. In the following description, details are listed for the purpose of explanation. It should be understood that a person of ordinary skill in the art will recognize that the present invention can be implemented without using these specific details. In other examples, well-known structures and processes will not be elaborated in detail to avoid obscuring the description of the present invention with unnecessary details. Therefore, the present invention is not intended to be limited to the embodiments shown, but is consistent with the widest scope consistent with the principles and features disclosed in this application.

[0022] refer to Figure 1 As shown, a centrifugal system adapted for bottom extraction comprises: The centrifuge body has a rotating drum inside and a bottom extraction device at the bottom of the drum; Dynamic sealing structure, which is set between the bottom extraction device and the drum, is used to maintain the sealing performance during the centrifugal process to prevent material leakage; Modular interface, which connects the bottom extraction device and the material collection container, facilitates quick replacement and adaptation of components of different specifications; The automated control system includes a sensor module, a PLC controller, and a remote monitoring module, which are used to monitor parameters during the centrifugation process, including speed, temperature, and pressure, in real time and achieve automated control.

[0023] It should be noted that the centrifuge drum is designed as the core component of the centrifuge. It is usually cylindrical or conical in structure, and the inner wall is provided with a wear-resistant coating to extend the service life. The material of the drum must have high strength and corrosion resistance to meet the centrifugal requirements of different materials. The separation structure is a detachable filter assembly. The aperture of the filter is selected according to the particle size of the material. The surface has micropores that allow liquid to pass through under the action of centrifugal force while preventing solid particles from passing through, achieving solid-liquid separation. Bottom extraction device: This device is installed at the bottom of the drum and is used to efficiently extract the centrifuged material. Its design must ensure the smoothness of the extraction process, avoid material blockage, and be adaptable to materials of different viscosities and particle sizes; Dynamic sealing structure includes: Porous materials: Porous materials have a microporous structure that can store lubricating media, such as lubricating oil or grease. These materials generally have high wear resistance and a low friction coefficient to adapt to high-speed rotation and high-temperature working environments. During the centrifugal process, the micropores in the porous material achieve self-circulation of the lubricating media through siphoning and pumping. This self-circulation mechanism ensures that the sealing surface can be continuously lubricated during high-speed rotation, reducing wear and improving sealing performance. T-slot design: A T-slot is engraved on the outer diameter of the sealing ring, half of which is in the porous material and the other half in the solid material. This segmented design helps to form a low-pressure area on the upwind side of the T-slot. During the centrifugal process, the hydrodynamic effect on the upwind side of the T-slot creates a low-pressure area. This low-pressure area draws the sealing medium from the porous material into the sealing gap through cavitation suction. Liquid film opening force: The inhaled sealing medium forms a liquid film in the sealing gap, which increases the opening force of the liquid film, thereby effectively preventing material leakage. At the same time, the lubricating effect of the liquid film reduces the friction and wear of the sealing surface.

[0024] refer to Figure 2 As shown, the sensor module includes: a speed sensor, a temperature sensor, a pressure sensor, and a material sensor; The speed sensor is used to monitor the speed of the centrifuge in real time to ensure that it operates within the set range; Temperature sensors are used to monitor temperature changes during centrifugation to prevent overheating that may cause material damage and equipment failure. The pressure sensor is used to monitor the pressure changes during the centrifugation process to ensure that the system operates at a safe pressure; Material sensors are used to detect the properties of the material in order to optimize the centrifugation parameters.

[0025] The application of the sensor module sensor specifically includes: Speed ​​sensor: Use photoelectric speed sensor and magnetoelectric speed sensor, installed on the main shaft and motor of the centrifuge, convert the speed signal into an electrical signal, and transmit it to the PLC controller for processing; Temperature sensor: Use thermocouples and thermal resistors, installed inside the drum and on the centrifuge casing. Regular calibration is required to ensure measurement accuracy, and software compensation algorithms are used to reduce the impact of ambient temperature. Connect to the PLC through an analog input interface, and the PLC will perform overheat protection and parameter adjustments based on temperature data. Pressure sensor: Piezoresistive pressure sensor and capacitive pressure sensor are usually installed at the feed port, discharge port and inside the drum of the centrifuge to convert the pressure signal into an electrical signal and transmit it to the PLC controller for processing; Material sensor: Infrared sensor, capacitive sensor, ultrasonic sensor are installed inside the drum and near the bottom extraction device. The material properties, including viscosity and density, are determined by detecting the reflection, capacitance change, and ultrasonic reflection of the material. The detected material property data is transmitted to the PLC, which optimizes the centrifugal parameters based on the data.

[0026] It should be noted that the speed sensor includes: Photoelectric speed sensor: detects marks or holes on rotating parts through the photoelectric effect and generates a pulse signal. The pulse frequency is proportional to the speed. Magnetoelectric speed sensor: uses the change of magnetic field to induce electromotive force, usually measuring the speed by detecting the change of gear or magnetic mark; Temperature sensors include: Thermocouple: Based on the Seebeck effect, when the junction temperatures of two different metal conductors of a thermocouple are different, a thermoelectric potential is generated, and the magnitude of the potential is proportional to the temperature difference; Thermal resistor: Utilizes the property that the resistance of metal or semiconductor materials changes with temperature and determines the temperature by measuring the change in resistance value; Pressure sensors include: Piezoresistive pressure sensor: Utilizes the piezoresistive effect of semiconductor materials. When pressure acts on the sensor, the resistance value changes, and the pressure is determined by measuring the resistance change. Capacitive pressure sensor: uses the change of capacitance to measure pressure. When pressure acts on the capacitive sensor, the capacitance value changes, and the pressure is determined by measuring the capacitance change. Material sensors include: Infrared sensor: determines the properties of the material, such as viscosity, density, etc., by detecting the infrared reflection characteristics of the material; Capacitive sensor: By detecting the change in capacitance of the material, the dielectric constant of the material is determined, thereby inferring the properties of the material; Ultrasonic sensor: By emitting and receiving ultrasonic waves, it detects the reflection characteristics of the material and determines the properties of the material, such as viscosity and density.

[0027] refer to Figure 3 As shown, the PLC controller has logic control function, signal acquisition function, data processing function, timing and counting function, output control function, remote input and output function, and human-machine interface function; Logic control function: Use PLC's AND, OR, and NOT commands to replace the series and parallel logic connections of relay contacts to achieve logic control, switch control, and sequence control; Signal acquisition function: collect analog signals, digital signals and pulse signals; Data processing function: PLC is used for data transmission, data comparison, data conversion, data shift, and arithmetic operations; Timing and counting function: realize execution timing and delay control, the time is set by the user and can be changed as needed; Output control function: output digital signals, analog signals and pulse signals to control external solenoid valves and indicator light equipment; Remote input and output function: Remote I / O function means that the remote I / O unit connects various input and output devices scattered at a long distance with the main controller, receives and processes signals, and realizes remote control; Human-machine interface function: realize human-machine interaction, monitor equipment operation status, alarm and status display and process control, realize parameter setting and online configuration; Fault self-diagnosis function: perform self-inspection on the system to detect and report faults in a timely manner.

[0028] It should be noted that the logic control functions include: AND, OR, NOT commands: Use these logic commands to combine and implement complex control logic. For example, the centrifuge is allowed to start only when the speed reaches the set value (AND condition) and the temperature is within the safe range (AND condition). Switch control: controls the start, stop and emergency brake operations of the centrifuge. For example, when the emergency brake button is pressed, the PLC immediately sends a signal to stop the motor; Sequential control: Executes a series of operations in a preset order, for example, starting the cooling system first, then starting the motor, and then gradually increasing the speed to ensure a smooth start of the centrifuge.

[0029] Data processing capabilities include: Data transmission: The collected sensor data is transmitted to the PLC for processing, and the data can also be sent to the host computer for further analysis; Data comparison: Compare the currently collected data with the preset thresholds, such as whether the temperature is too high or the pressure is abnormal, to determine whether control measures need to be taken; Data conversion: converting data in different formats into a unified format, such as converting analog signals into digital signals for easy processing and storage; Data shifting and arithmetic operations: Perform shift operations and basic arithmetic operations (such as addition, subtraction, multiplication, and division) on data to standardize data and calculate derived parameters (such as average value, trend value, etc.).

[0030] Output control functions include: Digital signal output: Output digital signal to control the switch of solenoid valve, such as controlling the expansion and contraction of the extraction pipe of the bottom extraction device; Analog signal output: Output analog signal to adjust the speed of the motor, for example, by adjusting the inverter through analog signal to change the speed of the motor; Pulse signal output: Output pulse signal to control stepper motor or other pulse drive equipment for precise position control or speed control.

[0031] Human-machine interface functions include: Human-computer interaction: The operator can interact with the PLC through the touch screen or operation panel, and the operator can view the equipment status, parameter settings and alarm information; Monitor equipment operating status: Real-time display of centrifuge operating parameters (such as speed, temperature, pressure, etc.) and equipment operating status (such as running, stopped, fault, etc.); Alarm and status display: When an abnormal situation occurs (such as overheating, overpressure, material blockage, etc.), the PLC will issue an audible and visual alarm through the human-machine interface and display specific fault information; Process control: The operator can manually or automatically adjust the centrifuge operating parameters such as speed, temperature, pressure, etc. through the human-machine interface to optimize the centrifugation process.

[0032] refer to Figure 4 As shown, the remote monitoring module includes real-time monitoring function, remote data acquisition, data processing and analysis, equipment failure alarm, remote control and operation, historical data storage and query, user interface and data query; Real-time monitoring function: through the communication protocol, real-time collection of equipment operating data, including temperature, pressure, and speed; Remote data acquisition: remote communication with field equipment is achieved through communication protocols; Data processing and analysis: Real-time processing and analysis of collected data, including data cleaning, filtering, and trend analysis; Equipment failure alarm: When the equipment data exceeds the preset range, the system can automatically alarm and notify the operator through sound, light, and text messages; Remote control and operation: remotely control the equipment through the host computer software, modify equipment parameters, start and stop equipment operations; Historical data storage and query: supports the storage, query and export of equipment data, helping production personnel analyze historical data and optimize equipment operation; User interface and data query: Displays the operating status of the device through a graphical interface, and supports data query and report export.

[0033] The data processing and analysis specifically include: Data cleaning: Identify and process outliers through statistical analysis and machine learning algorithms; convert data from different sources into a unified format to ensure data consistency; use interpolation and predictive models to fill missing values; identify and delete duplicate data records to improve data processing efficiency; Data filtering: The pass filter is used to remove high-frequency noise and retain low-frequency signals, and is suitable for smoothing speed and pressure data; the bandpass filter is used to extract signals within a specific frequency range, and is suitable for fine analysis of temperature and pressure data; the adaptive filter dynamically adjusts the filter parameters according to the data characteristics to adapt to different working conditions; Trend analysis: Using the moving average method to identify trends by calculating the moving average of data is suitable for short-term trend analysis; using the exponential smoothing method to assign higher weights to recent data points is suitable for medium- and long-term trend analysis; using the ARIMA model, the autoregressive integrated moving average model, is used for trend prediction of time series data; using wavelet analysis to decompose signals through wavelet transform and identify trends and characteristics at different time scales; Real-time processing and analysis: Use a stream processing framework to process real-time data to ensure low-latency responses; perform preliminary processing near the data source to reduce data transmission volume and improve processing efficiency; use a distributed computing framework to process large-scale data sets and increase processing speed.

[0034] It should be noted that the user interface and data query include: Graphical interface: Displays the operating status of the equipment through a graphical interface, including real-time data, trend charts, and equipment status; Data display: Provide intuitive data display to help operators quickly understand the operation status of the equipment; Report export: Supports the generation and export of data reports to facilitate further analysis and reporting.

[0035] Example: The centrifugal system of this embodiment mainly includes a centrifuge body, a dynamic sealing structure, a modular interface and an automated control system; The centrifuge body features a sturdy steel frame to ensure stability at high speeds. Inside, there's a cylindrical drum made of high-strength stainless steel with a ceramic wear-resistant coating on the inner wall to extend its service life. A feed port is located at the top of the drum, and a bottom extraction device is installed at the bottom. The drive mechanism uses a high-efficiency motor that drives the drum through a belt drive, ensuring it can reach and maintain the required speed.

[0036] The dynamic sealing structure uses a porous T-shaped fluid dynamic pressure groove mechanical seal, installed between the bottom extraction device and the drum. The porous material has a microporous structure that can store lubricating media, improving the opening force and lubrication performance of the sealing end face. The T-shaped groove is designed on the outer diameter side of the sealing ring, and the sealing medium is introduced into the sealing gap through cavitation suction, increasing the opening force of the liquid film and enhancing lubrication. This design ensures that during high-speed centrifugation, material will not leak from the gap between the bottom extraction device and the drum, ensuring the sealing performance of the system.

[0037] The modular interface adopts a standardized design and complies with ISO standards to ensure good compatibility and interchangeability between components from different manufacturers; the interface is equipped with a quick connector, allowing for rapid assembly and disassembly of components without the use of tools, significantly reducing the time and labor required for maintenance and replacement of components; a variety of adapters and conversion joints are provided to accommodate components of different specifications and types, making the system compatible with a variety of existing equipment; the interface is equipped with a sealing ring made of a rubber material resistant to chemical corrosion and high temperature to ensure the sealing of the connection and prevent material leakage.

[0038] The automated control system consists of a sensor module, a PLC controller, and a remote monitoring module. The sensor module consists of a speed sensor, a temperature sensor, a pressure sensor, and a material sensor, which respectively monitor the speed, temperature, pressure, and material properties during the centrifugation process in real time. The PLC controller connects to the sensor module via digital and analog input interfaces and adjusts the centrifuge's operating status according to pre-set control logic. The remote monitoring module connects to the host computer via Ethernet communication protocol, allowing operators to monitor the equipment's operating status in real time from a remote location.

[0039] Safety protection and maintenance: The centrifuge's base is equipped with shock-absorbing supports filled with elastic damping material to minimize the impact of vibrations generated during centrifugation on the surrounding environment. Safety features include an emergency stop button and door lock sensor, which quickly stop the centrifuge in the event of an emergency, ensuring operator safety. A modular interface design facilitates quick component replacement and maintenance, reducing equipment downtime and repair costs.

[0040] Medical Field Example: High-Purity Lymphocyte Isolation for CAR-T Cell Therapy Step 1: Assemble the modular interface, install a disposable biocompatible collection bag (ISO 13408 certified), and lock it with the bottom extraction device through the snap-on interface; switch to the 316L stainless steel low-temperature adapter (pre-cooled to 4℃±0.5℃) and connect the liquid nitrogen refrigeration circulation pipeline; Step 2: Dynamic sealing test, start the airtightness self-test program: inject 2.5bar helium, and the mass spectrometer detects the leakage rate <1×10⁻9 mbar·L / s, magnetic fluid sealing unit loaded with gradient magnetic field (0-1.2T adjustable); Step 3: Load the patient-specific protocol, scan the patient ID QR code, and automatically retrieve the following information from the electronic medical record: monocyte concentration (preset 3.8×10 6 cells / mL); serum protein electrophoresis data (IgM proportion ≤ 5%); Step 4: Fully enclosed sampling operation: insert the patient's peripheral blood collection tube (BD Vacutainer CPT™) into the automatic opening station, siphon the sample under negative pressure (to avoid aerosol generation), and inject it into the drum through the sterilization channel. The laser liquid level sensor confirms the loading volume (150mL±2mL); Step 5: Dynamic density gradient separation, with simultaneous injection of Ficoll-Paque PLUS layering solution (density 1.077 g / mL), and multispectral sensor tracking: the red blood cell layer (reflectance >85% at a wavelength of 620 nm) and the lymphocyte interface (Rayleigh scattering intensity mutation monitoring); Step 6: Three-stage intelligent extraction. In the first stage, the platelet layer is removed and pulse extraction is performed using a piezoelectric ceramic micropump (frequency 50 Hz, amplitude 0.1 mm) to avoid interface disturbances. Step 7: In the second stage, lymphocytes were collected by penetrating the separation interface through a fiber-optic guided puncture needle (Φ0.3 mm), and the flow rate was controlled by a mass flow meter (2 mL / min); Step 8: Residual serum recovery in the third stage is performed by vacuum-assisted extraction (-80 kPa) with a 0.22 μm sterilizing filter; Step 9: Activity maintenance control: maintain 6℃±0.3℃ throughout the collection process (thermocouple multi-point monitoring), and adjust the dissolved oxygen concentration (5-6.5mg / L) to prevent cellular oxidative stress; Step 10: Process quality analysis, online flow cytometry module (BD FACSLyric™ integrated) provides real-time feedback: CD3+ cell purity: 98.7% → meets the standard (>95%), platelet contamination: <0.1% → triggers the automatic secondary centrifugation procedure; Step 11: Generate electronic batch records (compliant with 21 CFR Part 11): Centrifugation efficiency index: 92.4 (baseline value ≥ 85), cell viability: 96.8% → better than the historical average (94.2%); Step 12: Remote consultation support: 5G transmits raw data to the hospital's cell therapy committee. Experts use AR glasses to view the 3D centrifugal field simulation image to confirm the integrity of the separation interface; Step 13: Hazardous waste treatment, the waste collection bag is automatically sealed and sterilized by gamma irradiation (25kGy dose), and the centrifuge chamber undergoes three-level cleaning: alkaline detergent (pH 12.5) to remove protein residues, peracetic acid sterilization (concentration 1500ppm, contact time 15min), and final rinsing with injection water (conductivity <1.5μS / cm).

[0041] It should be noted that, in the above embodiments, the description of each embodiment has its own focus. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant description of other embodiments.

[0042] Those skilled in the art will appreciate that embodiments of the present invention may provide methods, systems, or computer program products. Accordingly, the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to magnetic disk storage, CD-ROMs, optical storage, etc.) containing computer-usable program code.

[0043] The present invention is described with reference to flowcharts and / or block diagrams of methods, devices (systems), and computer program products according to embodiments of the present invention. It should be understood that each process and / or block in the flowcharts and / or block diagrams, as well as combinations of processes and / or blocks in the flowcharts and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, an embedded computer, or other programmable data processing device to produce a machine, so that the instructions executed by the processor of the computer or other programmable data processing device generate instructions for implementing the processes in the flowcharts and / or block diagrams. Figure 1 a process or multiple processes and / or boxes Figure 1 A device that provides the functions specified in a block or multiple blocks.

[0044] These computer program instructions may also be stored in a computer readable memory that can direct a computer or other programmable data processing device to work in a specific manner, so that the instructions stored in the computer readable memory produce an article of manufacture comprising an instruction device, which implements the process Figure 1 a process or multiple processes and / or boxes Figure 1 The function specified in one or more boxes.

[0045] These computer program instructions can also be loaded onto a computer or other programmable data processing device so that a series of operational steps are executed on the computer or other programmable device to produce a computer-implemented process, thereby providing the instructions executed on the computer or other programmable device for implementing the process. Figure 1 a process or multiple processes and / or boxes Figure 1 A step that specifies a function in one or more boxes.

[0046] Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0047] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such changes and modifications fall within the scope of the claims and their equivalents, the present invention is intended to include such changes and modifications.

Claims

1. A centrifugal system adapted for bottom extraction, characterized in that: include: The centrifuge body has a rotating drum inside and a bottom extraction device at the bottom of the drum; Dynamic sealing structure, which is set between the bottom extraction device and the drum, is used to maintain the sealing performance during the centrifugal process to prevent material leakage; Modular interface, which connects the bottom extraction device and the material collection container, facilitates quick replacement and adaptation of components of different specifications; The automated control system includes a sensor module, a PLC controller, and a remote monitoring module, which are used to monitor parameters during the centrifugation process, including speed, temperature, and pressure, in real time and achieve automated control.

2. A centrifugal system adapted for bottom extraction according to claim 1, characterized in that: The centrifuge body specifically includes: A supporting structure, which is used to fix and support the drum and includes a sturdy frame and shock-absorbing mounts; A driving mechanism, which is used to drive the drum to rotate, including a motor and a transmission device; The drum is equipped with a partition structure and a wear-resistant coating inside, which is used to contain and separate materials. The inner wall is provided with a wear-resistant coating, and the partition structure is a detachable filter assembly with micropores on the surface, which allows liquid to be exchanged under the action of centrifugal force while preventing solid particles from passing through; The bottom extraction device includes an extraction pipe, a driving mechanism and a material sensor; one end of the extraction pipe is connected to the material collection container, and the other end can be sealably connected to the discharge port at the bottom of the drum; the driving mechanism is used to control the extension and contraction of the extraction pipe, and includes a motor and a transmission device; the material sensor is arranged in the extraction pipe to detect the properties and flow of the material; the heating wire is arranged on the outer wall of the extraction pipe to prevent the material from condensing and clogging during the extraction process.

3. A centrifugal system adapted for bottom extraction according to claim 2, characterized in that: The dynamic sealing structure specifically includes: The dynamic sealing structure adopts porous materials, and its microporous structure is used to store lubricating media and realize self-circulation under the siphon and pumping action of the small hole flow channel; A T-slot is engraved on the outer diameter side of the sealing ring, half of which is porous and half is solid. The segmented porous T-slot mechanical seal structure creates a low-pressure area on the upwind side of the T-slot, introducing the sealing medium into the sealing gap through cavitation suction, increasing the liquid film opening force and enhancing lubrication.

4. A centrifugal system adapted for bottom extraction according to claim 3, characterized in that: The modular interface specifically includes: The modular interface adopts standardized mechanical and electrical interface design to transmit control signals and monitoring data; The interface is equipped with quick connectors, allowing for quick assembly and disassembly of components without the use of tools; The interface is equipped with seals to ensure the sealing of the connection and prevent material leakage; A wide variety of adapters and conversion connectors are available to accommodate different sizes and types of components.

5. The centrifugal system adapted for bottom extraction according to claim 4, characterized in that: The automatic control system specifically includes: Sensor module: including speed sensor, temperature sensor, pressure sensor, material sensor; The speed sensor is used to monitor the speed of the centrifuge in real time to ensure that it operates within the set range; Temperature sensors are used to monitor temperature changes during centrifugation to prevent overheating that may cause material damage and equipment failure. The pressure sensor is used to monitor the pressure changes during the centrifugation process to ensure that the system operates at a safe pressure; Material sensors are used to detect the properties of the material in order to optimize the centrifugation parameters.

6. A centrifugal system adapted for bottom extraction according to claim 5, characterized in that: The applications of the sensor module specifically include: Speed ​​sensor: Use photoelectric speed sensor and magnetoelectric speed sensor, installed on the main shaft and motor of the centrifuge, convert the speed signal into an electrical signal, and transmit it to the PLC controller for processing; Temperature sensor: Use thermocouples and thermal resistors, installed inside the drum and on the centrifuge casing. Regular calibration is required to ensure measurement accuracy, and software compensation algorithms are used to reduce the impact of ambient temperature. Connect to the PLC through an analog input interface, and the PLC will perform overheat protection and parameter adjustments based on temperature data. Pressure sensor: Piezoresistive pressure sensor and capacitive pressure sensor are usually installed at the feed port, discharge port and inside the drum of the centrifuge to convert the pressure signal into an electrical signal and transmit it to the PLC controller for processing; Material sensor: Infrared sensor, capacitive sensor, ultrasonic sensor are installed inside the drum and near the bottom extraction device. The material properties, including viscosity and density, are determined by detecting the reflection, capacitance change, and ultrasonic reflection of the material. The detected material property data is transmitted to the PLC, which optimizes the centrifugal parameters based on the data.

7. A centrifugal system adapted for bottom extraction according to claim 6, characterized in that: The automatic control system specifically includes: The PLC controller has logic control function, signal acquisition function, data processing function, timing and counting function, output control function, remote input and output function, and human-machine interface function; Logic control function: Use PLC's AND, OR, and NOT commands to replace the series and parallel logic connections of relay contacts to achieve logic control, switch control, and sequence control; Signal acquisition function: collect analog signals, digital signals and pulse signals; Data processing function: PLC is used for data transmission, data comparison, data conversion, data shift, and arithmetic operations; Timing and counting function: realize execution timing and delay control. The time is set by the user and can be changed as needed.

8. The centrifugal system adapted for bottom extraction according to claim 7, characterized in that: The PLC controller specifically includes: Output control function: output digital signals, analog signals and pulse signals to control external solenoid valves and indicator light equipment; Remote input and output function: Remote I / O function means that the remote I / O unit connects various input and output devices scattered at a long distance with the main controller, receives and processes signals, and realizes remote control; Human-machine interface function: realize human-machine interaction, monitor equipment operation status, alarm and status display and process control, realize parameter setting and online configuration; Fault self-diagnosis function: self-check the system, find and report faults in time; The system health status detection in the fault self-diagnosis function includes: Where FaultCode is the fault code, which is used to identify the specific fault detected in the system; Error type Error type, indicating the category or nature of the fault; n is the number of bits for the error type code; Error location The error location indicates the specific location or module where the fault occurs.

9. The centrifugal system adapted for bottom extraction according to claim 8, characterized in that: The automatic control system specifically includes: Remote monitoring module: including real-time monitoring function, remote data acquisition, data processing and analysis, equipment failure alarm, remote control and operation, historical data storage and query, user interface and data query; Real-time monitoring function: through the communication protocol, real-time collection of equipment operating data, including temperature, pressure, and speed; Remote data acquisition: remote communication with field equipment is achieved through communication protocols; Data processing and analysis: Real-time processing and analysis of collected data, including data cleaning, filtering, and trend analysis; Equipment failure alarm: When the equipment data exceeds the preset range, the system can automatically alarm and notify the operator through sound, light, and text messages; Remote control and operation: remotely control the equipment through the host computer software, modify equipment parameters, start and stop equipment operations; Historical data storage and query: supports the storage, query and export of equipment data, helping production personnel analyze historical data and optimize equipment operation; User interface and data query: Displays the operating status of the device through a graphical interface, and supports data query and report export.

10. The centrifugal system adapted for bottom extraction according to claim 9, characterized in that: The data processing and analysis specifically include: Data cleaning: Identify and process outliers through statistical analysis and machine learning algorithms; convert data from different sources into a unified format to ensure data consistency; use interpolation and predictive models to fill missing values; identify and delete duplicate data records to improve data processing efficiency; Data filtering: The pass filter is used to remove high-frequency noise and retain low-frequency signals, and is suitable for smoothing speed and pressure data; the bandpass filter is used to extract signals within a specific frequency range, and is suitable for fine analysis of temperature and pressure data; the adaptive filter dynamically adjusts the filter parameters according to the data characteristics to adapt to different working conditions; Trend analysis: Using the moving average method to identify trends by calculating the moving average of data is suitable for short-term trend analysis; using the exponential smoothing method to assign higher weights to recent data points is suitable for medium- and long-term trend analysis; using the ARIMA model, the autoregressive integrated moving average model, is used for trend prediction of time series data; using wavelet analysis to decompose signals through wavelet transform and identify trends and characteristics at different time scales; Real-time processing and analysis: Use a stream processing framework to process real-time data to ensure low-latency responses; perform preliminary processing near the data source to reduce data transmission volume and improve processing efficiency; use a distributed computing framework to process large-scale data sets and increase processing speed; The trend analysis in the data processing analysis includes: Where Y is the dependent variable, that is, the variable you want to predict or explain; X is the independent variable, that is, the variable used to predict or explain the dependent variable; a is the slope of the regression line, which represents the expected change in the dependent variable Y for each unit change in the independent variable X; b is the intercept of the regression line, which represents the expected value of the dependent variable Y when the independent variable X is 0; and n is the total number of data points.

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