Artificial skin dialysis detection equipment for medical dermatology department

Abstract

According to the technical scheme, the artificial skin dialysis detection equipment for the medical dermatology department is characterized by comprising a base, a fixing plate is fixedly installed on the top face of the base, a rotating table is arranged on the top face of the fixing plate, an adjusting hole is formed in the top face of the fixing plate, the rotating table is movably connected with the adjusting hole in a sleeved mode, and the rotating table is movably connected with the adjusting hole in a sleeved mode. A support frame is fixedly mounted on the top surface of the fixed plate; the detection assembly is arranged in the supporting frame and used for detecting the permeability of the artificial skin, a base, a fixing plate, a rotating table, the supporting frame, a storage box, a distinguishing plate, a connecting pipe, a transition box, a mounting plate, a fixing pipe, a spray head and a telescopic pipe which are arranged are used in cooperation, fluorescent emulsion is smeared on the artificial skin, the emulsion can permeate into the artificial skin, and the permeability of the artificial skin is detected. And the fluorescent agent enters the artificial skin and generates obvious fluorescent bright spots or areas under the irradiation of ultraviolet rays, so that a tiny permeation phenomenon can be accurately detected.

Description

Technical Field

[0001] The present invention relates to the technical field of artificial skin, in particular to an artificial skin dialysis property detection device for medical dermatology. Background Art

[0002] Artificial skin is a skin substitute artificially developed in vitro and should have good breathability similar to that of skin. Artificial skin is a skin substitute artificially developed in vitro and is divided into temporary replacement artificial skin and permanent artificial skin according to the different ways of combining with damaged skin. It is used to repair and replace defective skin tissue, especially in the treatment of burns and scalds. It can avoid transplanting healthy skin from the patient and the phenomenon of "taking money from one pocket to fill another". It also has good compatibility with the human body and generally does not cause immune rejection reactions. In order to realize the role of artificial skin in protecting wounds from infection and promoting the growth of connective tissue during the skin grafting process, it is required to have breathability similar to that of human skin to meet the environmental conditions for skin regeneration and prevent skin ulcers. Therefore, for artificial skin, good breathability is one of the basic properties that must be considered during its research and development and use.

[0003] In the existing technology, artificial skin needs to have a certain degree of breathability to ensure that it can promote wound healing and maintain a suitable skin microenvironment during use. Liquid and gas are used to test the permeability of artificial skin during testing. However, the pores of artificial skin are very small, and it is difficult to distinguish tiny penetration traces during slow penetration, and it is not easy to see the flow of liquid between the pores of artificial skin. Therefore, it is impossible to determine whether the liquid can pass through the artificial skin at the expected speed and amount, resulting in poor liquid release or excessive release, which will reduce the detection effect of artificial skin. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the present invention provides an artificial skin dialysis permeability detection device for medical dermatology to solve the problems raised in the above background technology.

[0005] The above technical objectives of the present invention are achieved through the following technical solutions:

[0006] A medical dermatology artificial skin dialysis test device, comprising a base, a fixed plate fixedly mounted on the top surface of the base, a rotating platform provided on the top surface of the fixed plate, an adjustment hole provided on the top surface of the fixed plate, the rotating platform movably connected to the adjustment hole, a support frame fixedly mounted on the top surface of the fixed plate; a detection component arranged inside the support frame for testing the permeability of the artificial skin, the detection component comprising: a partition plate fixedly mounted inside the support frame, a storage box fixedly mounted on the top surface of the support frame, a partition plate fixedly mounted inside the storage box, two discharge holes provided on one side of the storage box, the fixed plate A stabilizing frame is fixedly installed on the top surface of the fixed plate, and a transition box is fixedly installed inside the stabilizing frame. Two feed holes are provided on one side of the transition box, and a connecting pipe is fixedly sleeved on the inner circular wall of the discharge hole, and the connecting pipe is fixedly sleeved on the feed hole. A mounting plate is fixedly installed inside the transition box, and two fixing holes are provided on the top surface of the transition box, and a fixing pipe is fixedly sleeved on the inner circular wall of the fixing hole. Two mounting holes are provided on one side of the stabilizing frame, and a nozzle is fixedly sleeved on the inner circular wall of the mounting hole, and a telescopic tube is fixedly sleeved on the outer circular wall of the nozzle. Two limiting frames are fixedly installed on the bottom surface of the partition plate, and the limiting frames are fixedly sleeved on the telescopic tube.

[0007] By adopting the above technical solution, through the telescopic tube, when the staff conducts inspection on the artificial skin, they first put the emulsion into the storage box and mix the fluorescent agent in the emulsion, and then divide the space inside the storage box by the dividing plate, and then add the emulsion to the space on one side of the storage box, and at the same time add clean water to the space on the other side. Subsequently, the emulsion and clean water will enter the interior of the transition box through two connecting tubes respectively. Since the internal space of the transition box is divided by the installation plate, the emulsion and clean water enter the two independent spaces inside the transition box, and then the artificial skin is placed on the surface of the rotating table, and then the nozzle is used to let the emulsion spray out through the nozzle and the telescopic tube. At the same time, since the telescopic tube is retractable, the staff can pull the telescopic tube and pull the nozzle of the telescopic tube to the surface of the artificial skin so as to apply the fluorescent emulsion to the surface of the artificial skin, and then observe the fluorescence distribution with the naked eye to quickly confirm. To determine the overall penetration range of the penetrating substance, by applying fluorescent emulsion to the artificial skin, the emulsion will penetrate into the artificial skin, and the fluorescent agent will then enter the artificial skin and produce obvious fluorescent bright spots or areas under ultraviolet irradiation, so that tiny penetration phenomena can be accurately detected, which is convenient for real-time monitoring of the penetration process of drugs in the artificial skin. At the same time, when the staff use an electron microscope to observe the artificial skin samples after adding the fluorescent agent, they can find the areas where the fluorescent agent mainly accumulates on the artificial skin, such as around pores or parts where the material cross-linking is weak, which helps to gain a deeper understanding of the relationship between the structure and permeability of the artificial skin. By using a second nozzle and a telescopic tube, the staff can spray clean water on the surface of the artificial skin, which facilitates the detection of the penetration effect of water on the artificial skin, and at the same time compare the penetration effects of clean water and emulsion to improve the detection of the penetration effect of artificial skin.

[0008] Preferably, the top surface of the rotating platform is provided with a smearing component for rubbing the artificial skin;

[0009] The smearing assembly includes: an adjusting column, the adjusting column is arranged on the top surface of the rotating table, the bottom surface of the adjusting column is fixedly installed with a mounting shell, a driving motor is fixedly installed inside the mounting shell, a positioning plate is fixedly installed on one side of the mounting shell, a rotating wheel is provided on one side of the positioning plate, a driving shaft of the driving motor passes through the positioning plate and is fixedly installed with the rotating wheel, a fixing column is fixedly installed on one side of the positioning plate, a displacement column is fixedly installed on one end of the rotating wheel, a swing column is provided on one side of the rotating wheel, a sliding hole is opened on one side of the swing column, the sliding hole is slidably connected to the displacement column, a center hole is opened on one side of the swing column, the center hole is movably socketed with the fixed column, and an smearing plate is fixedly installed on the bottom surface of the swing column.

[0010] By adopting the above technical solution, through the provided smear plate, when the staff applies the emulsion on the artificial skin, by using the driving motor, the rotation of the driving shaft of the driving motor will drive the rotating wheel to rotate, and then the rotating wheel will drive the displacement column to perform circular motion. The displacement column will continuously change its position while following the rotation of the rotating wheel, and drive the swing column and the smear plate to swing left and right around the fixed column. At this time, the smear plate is attached to the surface of the artificial skin, so the smear plate will repeatedly and evenly apply the emulsion on the artificial skin during the swing, which is convenient for the staff to detect the penetration rate of the emulsion being applied on the artificial skin.

[0011] Preferably, the top surface of the rotating platform is provided with an auxiliary component for assisting detection of the artificial skin;

[0012] The auxiliary component includes: a mounting groove, which is opened on the top surface of the rotating table, a first ultraviolet lamp is fixedly installed inside the mounting groove, a transparent plate is fixedly installed inside the mounting groove, a fixing frame is provided on the top surface of the rotating table, a clamping frame is provided on the top surface of the fixing frame, an illuminating groove is respectively opened inside the fixing frame and the clamping frame, a second ultraviolet lamp is fixedly installed inside the illuminating groove, and a transparent strip is fixedly sleeved inside the illuminating groove.

[0013] By adopting the above technical solution, through the provision of the first ultraviolet lamp, after the fluorescent emulsion is applied to the surface of the artificial skin, the fluorescent emulsion on the artificial skin can be illuminated and visualized by turning on the first ultraviolet lamp and the second ultraviolet lamp, so that the penetration of the fluorescent emulsion can be observed in real time, which is convenient for assisting staff to perform penetration detection on the artificial skin.

[0014] Preferably, the bottom surface of the clamping frame is provided with a clamping component for restricting the artificial skin;

[0015] The top of described sliding panel also is provided with an interlocking plate, and the interlocking plate is hinged on the base plate, is fixed with a backing plate, and an end of sliding panel withstands on the backing of the interlocking plate, and the like is locked.

[0016] By adopting the above technical solution, through the setting of the clamping frame, the staff can separate the clamping frame and the fixed frame into an L shape by rotating the clamping frame to drive the connecting plate and the rotating column to rotate. Then the staff puts the artificial skin on the top surface of the fixed frame, and then rotates the clamping frame to drive the clamping block to reset so that the clamping frame is pressed on the surface of the fixed frame, and the clamping block enters the inside of the clamping groove, so that the artificial skin can be clamped between the fixed frame and the clamping frame for applying the emulsion. When the fixed frame and the clamping frame clamp the artificial skin, the snap-fit ​​hole will be stuck in the locking block. By pressing the push block to squeeze the spring to move, the push block and the locking block will be pushed into the inside of the operating groove, thereby releasing the restriction on the limiting plate so that the fixed frame and the clamping frame can be separated.

[0017] Preferably, the top surface of the rotating platform is provided with an adjustment component for changing the position of the artificial skin;

[0018] The adjustment assembly includes: a support column, which is fixedly installed on the top surface of the rotating table, a hydraulic rod is fixedly installed on one side of the support column, a mobile table is movably sleeved on the outside of the support column, a telescopic rod of the hydraulic rod is fixedly installed on the mobile table, a fixing groove is provided on one side of the mobile table, a stepping motor is fixedly sleeved inside the fixing groove, a driving shaft of the stepping motor is fixedly installed on the fixing frame, a reserved groove is provided on the top surface of the base, a limiting frame is fixedly installed on the bottom surface of the fixing plate, a supporting hole is provided on the bottom surface of the limiting frame, a servo motor is fixedly sleeved inside the support hole, and the driving shaft of the servo motor is fixedly installed on the rotating table.

[0019] By adopting the above technical solution, a movable platform is set up, and by using a hydraulic rod, the telescopic rod of the hydraulic rod moves the movable platform, the fixed frame and the clamping frame upward, and then a stepping motor is used to drive the fixed frame and the clamping frame to rotate, the artificial skin can be changed from a flat state to an upright state, thereby facilitating the adjustment of the direction of the artificial skin to adapt to subsequent different tests, and the artificial skin in the upright state can be flushed with clean water to test the toughness of the artificial skin under flushing.

[0020] Preferably, a stabilizing hole is opened on one side of the support frame, a fan is fixedly sleeved inside the stabilizing hole, and a dustproof net is fixedly installed on one side of the support frame.

[0021] By adopting the above technical solution and providing a fan, and by using the fan to blow air on the artificial skin, it is convenient to test the air permeability of the artificial skin and the toughness of the artificial skin under the action of wind.

[0022] Preferably, a mounting frame is fixedly installed inside the support frame, a movable hole is provided on the top surface of the mounting frame, two sliding blocks are fixedly installed on the inner circular wall surface of the movable hole, the adjusting column is movably connected to the movable hole, two limiting grooves are provided on the outer circular wall surface of the adjusting column, a plurality of positioning grooves are provided on the outer circular wall surface of the adjusting column, the positioning grooves are communicated with the limiting grooves, and the sliding blocks are slidably connected to the limiting grooves.

[0023] By adopting the above technical solution, through the setting of the adjustment column, the staff can push the adjustment column upward to drive the mounting shell and the positioning plate to move, so that the position of the adjustment column and the positioning plate can be raised. Then, by rotating the adjustment column to allow the sliding block to enter the interior of the positioning groove, the raised adjustment column can be restricted, thereby making it easier to keep the application plate away from the top of the rotating table so that the staff can take and put in the artificial skin.

[0024] Preferably, two injection holes are provided on the top surface of the storage box, and sealing plugs are movably sleeved on the inner circular wall surfaces of the injection holes.

[0025] By adopting the above technical solution, the interior of the storage box is injected with emulsion and clean water.

[0026] In summary, the present invention mainly has the following beneficial effects:

[0027] By cooperating with each other, the base, fixed plate, rotating table, support frame, storage box, dividing plate, connecting pipe, transition box, mounting plate, fixed pipe, nozzle and telescopic tube, the nozzle of the telescopic tube is pulled to the surface of the artificial skin so that the surface of the artificial skin can be coated with fluorescent emulsion. Then, by observing the fluorescence distribution with the naked eye, the overall penetration range of the penetrating substance can be quickly determined. By applying the fluorescent emulsion to the artificial skin, the emulsion will penetrate into the artificial skin, and the fluorescent agent will also enter the artificial skin and produce obvious fluorescent bright spots or areas under ultraviolet light, so that tiny penetration phenomena can be accurately detected, facilitating real-time monitoring of the drug penetration process in the artificial skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0029] Figure 2 It is a schematic diagram of the base structure of the present invention;

[0030] Figure 3 It is a schematic structural diagram of the storage box of the present invention;

[0031] Figure 4 It is a schematic structural diagram of the transition box of the present invention;

[0032] Figure 5 It is a schematic structural diagram of the partition plate of the present invention;

[0033] Figure 6 It is a schematic diagram of the support frame structure of the present invention;

[0034] Figure 7 It is a schematic structural diagram of the mounting frame of the present invention;

[0035] Figure 8 yes Figure 7 Schematic diagram of the local structure of A;

[0036] Figure 9 It is a schematic diagram of the structure of the regulating column of the present invention;

[0037] Figure 10 It is a schematic structural diagram of the rotary table of the present invention;

[0038] Figure 11 It is a schematic diagram of the transparent plate structure of the present invention;

[0039] Figure 12 It is a schematic diagram of the support column structure of the present invention;

[0040] Figure 13 It is a schematic diagram of the clamping frame structure of the present invention;

[0041] Figure 14 It is a schematic diagram of the fixed frame structure of the present invention;

[0042] Figure 15 It is a schematic diagram of the limit frame structure of the present invention;

[0043] Figure 16 It is a schematic diagram of the stable hole structure of the present invention.

[0044] Figure numerals: 1, base; 2, fixed plate; 3, rotating table; 4, adjusting hole; 5, supporting frame; 6, partition plate; 7, storage box; 8, dividing plate; 9, discharge hole; 10, connecting pipe; 11, stabilizing frame; 12, transition box; 13, feeding hole; 14, mounting plate; 15, fixing hole; 16, fixing pipe; 17, supporting hole; 18, mounting hole; 19, nozzle; 20, telescopic tube; 21, injection hole; 22, limiting frame; 23, limiting frame; 24, mounting frame; 25, movable hole; 26, sliding block; 27, adjusting column; 28, limiting groove; 29, positioning groove; 30, mounting shell; 31, positioning plate; 32, driving motor; 33, fixing column; 34, rotating wheel; 35, displacement column; 36, swing Column; 37. Sliding hole; 38. Center hole; 39. Applicator plate; 40. Mounting slot; 41. First UV lamp; 42. Transparent plate; 43. Fixed frame; 44. Clamping frame; 45. Illuminating slot; 46. Second UV lamp; 47. Transparent strip; 48. Connecting plate; 49. Rotating column; 50. Connecting frame; 51. Rotating slot; 52. Clamping block; 53. Pressing slot; 54. Limiting plate; 55. Snap-on hole; 56. Operating slot; 57. Operating column; 58. Spring; 59. Pushing block; 60. Pressing hole; 61. Locking block; 62. Support column; 63. Hydraulic rod; 64. Moving platform; 65. Servo motor; 66. Fixed slot; 67. Stepping motor; 68. Stabilizing hole; 69. Fan; 70. Reserved slot. DETAILED DESCRIPTION

[0045] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0046] Example 1: Reference Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5 and Figure 6, an artificial skin dialysis detection device for medical dermatology, comprising a base 1, a fixed plate 2 is fixedly installed on the top surface of the base 1, a rotating table 3 is provided on the top surface of the fixed plate 2, an adjustment hole 4 is provided on the top surface of the fixed plate 2, the rotating table 3 is movably connected to the adjustment hole 4, a support frame 5 is fixedly installed on the top surface of the fixed plate 2, a detection component is provided inside the support frame 5 for detecting the permeability of the artificial skin, the detection component comprises a partition plate 6, the partition plate 6 is fixedly installed inside the support frame 5, a storage box 7 is fixedly installed on the top surface of the support frame 5, a partition plate 8 is fixedly installed inside the storage box 7, two discharge holes 9 are provided on one side of the storage box 7, a stabilizing frame 11 is fixedly installed on the top surface of the fixed plate 2, and a stabilizing frame 11 is fixedly installed inside A transition box 12 is provided on one side of the transition box 12 with two feed holes 13, the inner circular wall surface of the discharge hole 9 is fixedly sleeved with a connecting pipe 10, and the connecting pipe 10 is fixedly sleeved with the feed hole 13. A mounting plate 14 is fixedly installed inside the transition box 12, and two fixing holes 15 are provided on the top surface of the transition box 12, and a fixing pipe 16 is fixedly sleeved on the inner circular wall surface of the fixing hole 15. Two mounting holes 18 are provided on one side of the stabilizing frame 11, and a nozzle 19 is fixedly sleeved on the inner circular wall surface of the mounting hole 18, and a telescopic tube 20 is fixedly sleeved on the outer circular wall surface of the nozzle 19. Two limiting frames 22 are fixedly installed on the bottom surface of the partition plate 6, and the limiting frame 22 is fixedly sleeved with the telescopic tube 20. Through the provided telescopic tube 20, when the staff detects the artificial skin, they first pass through the storage Emulsion is put into the storage box 7 and fluorescent agent is mixed with the emulsion. The space inside the storage box 7 is divided by the dividing plate 8. After the emulsion is added to the space on one side of the storage box 7, clean water is added to the space on the other side. Then, the emulsion and clean water enter the interior of the transition box 12 through two connecting pipes 10 respectively. Since the internal space of the transition box 12 is divided by the mounting plate 14, the emulsion and clean water enter the two independent spaces inside the transition box 12. Then, the artificial skin is placed on the surface of the rotating table 3, and the nozzle 19 is used to spray the emulsion through the nozzle 19 and the telescopic tube 20. At the same time, since the telescopic tube 20 is retractable, the staff can pull the telescopic tube 20 to pull the nozzle of the telescopic tube 20 to the surface of the artificial skin. In order to apply fluorescent emulsion to the surface of artificial skin and then observe the fluorescence distribution with the naked eye, the overall penetration range of the penetrating substance can be quickly determined. By applying fluorescent emulsion to artificial skin, the emulsion will penetrate into the artificial skin, and the fluorescent agent will then enter the artificial skin and produce obvious fluorescent bright spots or areas under ultraviolet irradiation, so that tiny penetration phenomena can be accurately detected, which is convenient for real-time monitoring of the drug penetration process in artificial skin. At the same time, when the staff use an electron microscope to observe the artificial skin sample after adding the fluorescent agent, they can find the areas where the fluorescent agent mainly accumulates on the artificial skin, such as around pores or parts with weak material cross-linking, which helps to gain a deeper understanding of the relationship between the structure and permeability of artificial skin.By using the second nozzle 19 and the telescopic tube 20, the staff can spray clean water on the surface of the artificial skin, thereby facilitating the detection of the water penetration effect on the artificial skin and comparing the penetration effect of clean water and emulsion, thereby improving the detection of the penetration effect of the artificial skin.

[0047] Example 2: Based on the above Example 1, reference Figure 1 、 Figure 2 、 Figure 3 、 Figure 6 、 Figure 9 、 Figure 10 、 Figure 11 、 Figure 12 and Figure 13The top surface of the rotating platform 3 is provided with an application component for rubbing the artificial skin. The application component includes an adjusting column 27. The adjusting column 27 is provided on the top surface of the rotating platform 3. A mounting shell 30 is fixedly installed on the bottom surface of the adjusting column 27. A driving motor 32 is fixedly installed inside the mounting shell 30. A positioning plate 31 is fixedly installed on one side of the mounting shell 30. A rotating wheel 34 is provided on one side of the positioning plate 31. The driving shaft of the driving motor 32 passes through the positioning plate 31 and is fixedly installed with the rotating wheel 34. A fixing column 33 is fixedly installed on one side of the positioning plate 31. A displacement column 35 is fixedly installed on one end of the rotating wheel 34. A swing column 36 is provided on one side, and a sliding hole 37 is provided on one side of the swing column 36. The sliding hole 37 is slidably connected to the displacement column 35. A center hole 38 is provided on one side of the swing column 36. The center hole 38 is movably connected to the fixed column 33. A smear plate 39 is fixedly installed on the bottom surface of the swing column 36. Through the smear plate 39, when the staff applies the emulsion on the artificial skin, by using the driving motor 32, the rotation of the driving shaft of the driving motor 32 will drive the rotating wheel 34 to rotate, and then the rotating wheel 34 will drive the displacement column 35 to perform a circular motion. The displacement column 35 will continuously change its position while following the rotation of the rotating wheel 34. The smear plate 39 is placed on the artificial skin and drives the swing column 36 and the smear plate 39 to swing left and right around the fixed column 33. At this time, the smear plate 39 is attached to the surface of the artificial skin, so the smear plate 39 will repeatedly and evenly apply the emulsion on the artificial skin during the swing, which is convenient for the staff to detect the penetration speed of the emulsion being applied on the artificial skin. The top surface of the rotating table 3 is provided with an auxiliary component for auxiliary detection of the artificial skin. The auxiliary component includes a mounting groove 40. The mounting groove 40 is opened on the top surface of the rotating table 3. The first ultraviolet lamp 41 is fixedly installed inside the mounting groove 40. The transparent plate 42 is fixedly installed inside the mounting groove 40. A fixing frame 43 is provided on the top surface of the turntable 3, and a clamping frame 44 is provided on the top surface of the fixing frame 43. An illuminating groove 45 is respectively provided inside the fixing frame 43 and the clamping frame 44. A second ultraviolet lamp 46 is fixedly installed inside the illuminating groove 45, and a transparent strip 47 is fixedly sleeved inside the illuminating groove 45. Through the provided first ultraviolet lamp 41, when the fluorescent emulsion is applied to the surface of the artificial skin, the fluorescent emulsion on the artificial skin can be irradiated and visualized by turning on the first ultraviolet lamp 41 and the second ultraviolet lamp 46, so as to observe the penetration of the fluorescent emulsion in real time, which is convenient for assisting staff to perform penetration detection on the artificial skin.

[0048] Example 3: Based on the above Example 1 or 2, refer to Figure 1 、 Figure 6 、 Figure 10 、 Figure 11 、 Figure 12 、 Figure 13 、 Figure 14 and Figure 15The bottom surface of the clamping frame 44 is provided with a clamping assembly for limiting the artificial skin. The clamping assembly includes a connecting plate 48, which is fixedly mounted on the bottom surface of the clamping frame 44. Rotating columns 49 are fixedly mounted on both sides of the connecting plate 48. A connecting frame 50 is fixedly mounted on the top surface of the fixed frame 43. Rotating grooves 51 are respectively provided on both sides of the connecting frame 50. The rotating columns 49 are movably connected with the rotating grooves 51. A plurality of clamping blocks 52 are fixedly mounted on the bottom surface of the clamping frame 44. A plurality of pressing grooves 53 are provided on the top surface of the fixed frame 43. The pressing grooves 53 are movably connected with the clamping blocks 52. A limiting plate 54 is fixedly mounted on the bottom surface of the clamping frame 44. A clamping hole 55 is provided on one side of the limiting plate 54. An operating groove 51 is provided on one side of the fixed frame 43. 6. Two operating columns 57 are provided on one side of the inner part of the operating groove 56. The outer cylindrical wall of the operating column 57 is movably sleeved with a spring 58. A pushing block 59 is movably sleeved inside the operating groove 56. Two pressing holes 60 are provided on one side of the pushing block 59. The pressing holes 60 are movably sleeved with the operating column 57. A locking block 61 is fixedly installed on one side of the pushing block 59. The locking block 61 is movably sleeved with the clamping hole 55. Through the provided clamping frame 44, the staff drives the connecting plate 48 and the rotating column 49 to rotate by rotating the clamping frame 44, and the clamping frame 44 and the fixed frame 43 can be separated into an L shape. Then the staff puts the artificial skin on the top surface of the fixed frame 43, and then rotates the clamping frame 44 to drive the clamping block 52 to reset so that the clamping frame 44 is pressed on the fixed frame 4 3, and the clamping block 52 enters the interior of the pressing groove 53, so that the artificial skin can be clamped between the fixed frame 43 and the clamping frame 44 for applying emulsion. When the fixed frame 43 and the clamping frame 44 clamp the artificial skin, the clamping hole 55 will be stuck in the interior of the locking block 61, and by pressing the pushing block 59 to squeeze the spring 58 to move, the pushing block 59 and the locking block 61 will be pushed into the interior of the operating groove 56, so that the restriction on the limiting plate 54 can be released, so that the fixed frame 43 and the clamping frame 44 can be separated. The top surface of the rotating table 3 is provided with an adjustment component for changing the position of the artificial skin, and the adjustment component includes a support column 62, which is fixedly mounted on the top surface of the rotating table 3, and a hydraulic rod 6 is fixedly mounted on one side of the support column 62. 3. The outer movability of the support column 62 is connected to the movable platform 64, and the telescopic rod of the hydraulic rod 63 is fixedly installed with the movable platform 64. A fixed groove 66 is provided on one side of the movable platform 64. A stepper motor 67 is fixedly connected to the inner part of the fixed groove 66. The drive shaft of the stepper motor 67 is fixedly installed with the fixed frame 43. A reserved groove 70 is provided on the top surface of the base 1. The limit frame 23 is fixedly installed on the bottom surface of the fixed plate 2. The bottom surface of the limit frame 23 is provided with a support hole 17. The servo motor 65 is fixedly connected to the inner part of the support hole 17. The drive shaft of the servo motor 65 is fixedly installed with the rotating platform 3. By setting the movable platform 64, by using the hydraulic rod 63, the telescopic rod of the hydraulic rod 63 moves to drive the movable platform 64, the fixed frame 43 and the clamping frame 44 to move upward.Then, by using the stepper motor 67 to drive the fixed frame 43 and the clamping frame 44 to rotate, the artificial skin can be changed from the flat state to the upright state, thereby facilitating the adjustment of the direction of the artificial skin to adapt to different subsequent tests. In addition, the artificial skin in the upright state can be flushed with clean water to test the toughness of the artificial skin under flushing.

[0049] Example 4: Based on the above examples 1, 2 or 3, refer to Figure 1 、 Figure 2 、 Figure 3 、 Figure 7 、 Figure 8 、 Figure 9 and Figure 16 A stabilizing hole 68 is provided on one side of the support frame 5, and a fan 69 is fixedly connected to the inside of the stabilizing hole 68. A dust net is fixedly installed on one side of the support frame 5. By setting the fan 69, the artificial skin is blown by using the fan 69, which is convenient for detecting the air permeability of the artificial skin and the toughness of the artificial skin under the action of wind. A mounting frame 24 is fixedly installed on the inside of the support frame 5, and a movable hole 25 is provided on the top surface of the mounting frame 24. Two sliding blocks 26 are fixedly installed on the inner circular wall surface of the movable hole 25. The adjusting column 27 is movably connected to the movable hole 25. The outer circular wall surface of the adjusting column 27 is provided with two limiting grooves 28, and the outer circular wall surface of the adjusting column 27 is provided with a plurality of fixed The positioning groove 29 is connected to the limiting groove 28, and the sliding block 26 is slidably connected to the limiting groove 28. Through the setting adjustment column 27, the staff drives the mounting shell 30 and the positioning plate 31 to move by pushing the adjustment column 27 upward, so that the position of the adjustment column 27 and the positioning plate 31 can be raised, and then the sliding block 26 is allowed to enter the interior of the positioning groove 29 by rotating the adjustment column 27, which can limit the raised adjustment column 27, thereby making it easier to keep the smear plate 39 away from the top of the rotating table 3, so that the staff can take and put in the artificial skin. The top surface of the storage box 7 is provided with two injection holes 21, and the inner circular wall surface of the injection hole 21 is movably connected with a sealing plug.

[0050] Working principle: Please refer to Figures 1-16As shown, through the provided telescopic tube 20, when the staff conducts inspection on the artificial skin, they first put the emulsion into the storage box 7 and mix the fluorescent agent in the emulsion, and then divide the space inside the storage box 7 by the dividing plate 8, and then add the emulsion to the space on one side of the storage box 7, and at the same time add clean water to the space on the other side. Subsequently, the emulsion and clean water will enter the interior of the transition box 12 through the two connecting tubes 10 respectively. Since the internal space of the transition box 12 is divided by the mounting plate 14, the emulsion and clean water enter the two independent spaces inside the transition box 12, and then the artificial skin is placed on the surface of the rotating table 3, and then the nozzle 19 is used to allow the emulsion to be sprayed out through the nozzle 19 and the telescopic tube 20. At the same time, since the telescopic tube 20 is telescopic, the staff can pull the telescopic tube 20 and pull the nozzle of the telescopic tube 20 to the surface of the artificial skin so as to apply the fluorescent emulsion to the surface of the artificial skin, and then observe the fluorescence with the naked eye. Distribution, the overall penetration range of the penetrating substance can be quickly determined. By applying fluorescent emulsion to the artificial skin, the emulsion will penetrate into the artificial skin, and the fluorescent agent will then enter the artificial skin and produce obvious fluorescent bright spots or areas under ultraviolet irradiation, so that tiny penetration phenomena can be accurately detected, which is convenient for real-time monitoring of the penetration process of drugs in the artificial skin. At the same time, when the staff use an electron microscope to observe the artificial skin sample after adding the fluorescent agent, it can be found that the fluorescent agent mainly accumulates in the artificial skin, such as around the pores or the parts with weak material cross-linking, which helps to gain a deeper understanding of the relationship between the structure and permeability of the artificial skin. By using the second nozzle 19 and the telescopic tube 20, the staff can spray clean water on the surface of the artificial skin, which is convenient for detecting the penetration effect of water on the artificial skin, and at the same time compare the penetration effects of clean water and emulsion, so as to improve the detection of the penetration effect of artificial skin.

[0051] Through the provided smear plate 39, when the staff applies the emulsion on the artificial skin, by using the drive motor 32, the rotation of the drive shaft of the drive motor 32 will drive the rotating wheel 34 to rotate, and then the rotating wheel 34 will drive the displacement column 35 to perform a circular motion. The displacement column 35 will continuously change its position while following the rotation of the rotating wheel 34, and drive the swing column 36 and the smear plate 39 to swing left and right around the fixed column 33. At this time, the smear plate 39 is attached to the surface of the artificial skin, so the smear plate 39 will repeatedly and evenly apply the emulsion on the artificial skin during the swing, which is convenient for the staff to detect the penetration rate of the emulsion being applied on the artificial skin.

[0052] By setting up the first ultraviolet lamp 41, when the fluorescent emulsion is applied to the surface of the artificial skin, the fluorescent emulsion on the artificial skin can be illuminated and visualized by turning on the first ultraviolet lamp 41 and the second ultraviolet lamp 46, so that the penetration of the fluorescent emulsion can be observed in real time, which is convenient for assisting staff to perform penetration detection on the artificial skin.

[0053] By setting the clamping frame 44, the staff can separate the clamping frame 44 and the fixed frame 43 into an L shape by rotating the clamping frame 44 to drive the connecting plate 48 and the rotating column 49 to rotate. Then the staff puts the artificial skin on the top surface of the fixed frame 43, and then rotates the clamping frame 44 to drive the clamping block 52 to reset so that the clamping frame 44 is pressed on the surface of the fixed frame 43, and the clamping block 52 enters the inside of the pressing groove 53, so that the artificial skin can be clamped between the fixed frame 43 and the clamping frame 44 for applying the emulsion. When the fixed frame 43 and the clamping frame 44 clamp the artificial skin, the clamping hole 55 will be stuck in the inside of the locking block 61. By pressing the push block 59 to squeeze the spring 58 to move, the push block 59 and the locking block 61 will be pushed into the inside of the operating groove 56, thereby releasing the restriction on the limiting plate 54, so that the fixed frame 43 and the clamping frame 44 can be separated.

[0054] By setting up a movable platform 64, by using the hydraulic rod 63, the telescopic rod of the hydraulic rod 63 moves the movable platform 64, the fixed frame 43 and the clamping frame 44 upward, and then by using the stepping motor 67 to drive the fixed frame 43 and the clamping frame 44 to rotate, the artificial skin can be changed from a flat state to an upright state, thereby facilitating the adjustment of the direction of the artificial skin to adapt to subsequent different tests, and the artificial skin in the upright state can be flushed with clean water to test the toughness of the artificial skin under flushing.

[0055] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A medical dermatology artificial skin dialysis detection device, comprising a base (1), a fixed plate (2) fixedly mounted on the top surface of the base (1), a rotating platform (3) provided on the top surface of the fixed plate (2), an adjustment hole (4) provided on the top surface of the fixed plate (2), the rotating platform (3) and the adjustment hole (4) movably connected, and a support frame (5) fixedly mounted on the top surface of the fixed plate (2), characterized in that: A detection component is arranged inside the support frame (5) and is used to detect the permeability of the artificial skin. The detection component comprises: a partition plate (6), the partition plate (6) is fixedly installed inside the support frame (5), a storage box (7) is fixedly installed on the top surface of the support frame (5), a partition plate (8) is fixedly installed inside the storage box (7), two discharge holes (9) are opened on one side of the storage box (7), a stabilizing frame (11) is fixedly installed on the top surface of the fixing plate (2), a transition box (12) is fixedly installed inside the stabilizing frame (11), two feed holes (13) are opened on one side of the transition box (12), and the inner circular wall surface of the discharge hole (9) is fixedly sleeved. A connecting pipe (10) is provided, the connecting pipe (10) is fixedly sleeved with the feed hole (13), a mounting plate (14) is fixedly installed inside the transition box (12), two fixing holes (15) are provided on the top surface of the transition box (12), a fixing pipe (16) is fixedly sleeved on the inner circular wall surface of the fixing hole (15), two mounting holes (18) are provided on one side of the stabilizing frame (11), a nozzle (19) is fixedly sleeved on the inner circular wall surface of the mounting hole (18), a telescopic tube (20) is fixedly sleeved on the outer circular wall surface of the nozzle (19), and two limiting frames (22) are fixedly installed on the bottom surface of the partition plate (6), and the limiting frames (22) are fixedly sleeved on the telescopic tube (20).

2. The artificial skin dialysis testing device for medical dermatology according to claim 1, characterized in that: The top surface of the rotating platform (3) is provided with a smearing component for rubbing the artificial skin; The smearing assembly comprises: an adjusting column (27), the adjusting column (27) is arranged on the top surface of the rotating platform (3), a mounting shell (30) is fixedly installed on the bottom surface of the adjusting column (27), a driving motor (32) is fixedly installed inside the mounting shell (30), a positioning plate (31) is fixedly installed on one side of the mounting shell (30), a rotating wheel (34) is provided on one side of the positioning plate (31), a driving shaft of the driving motor (32) passes through the positioning plate (31) and is fixedly installed with the rotating wheel (34), and the positioning plate ( A fixed column (33) is fixedly installed on one side of the rotating wheel (31), a displacement column (35) is fixedly installed on one end of the rotating wheel (34), a swing column (36) is provided on one side of the rotating wheel (34), a sliding hole (37) is provided on one side of the swing column (36), the sliding hole (37) is slidably connected to the displacement column (35), a center hole (38) is provided on one side of the swing column (36), the center hole (38) is movably connected to the fixed column (33), and a smear plate (39) is fixedly installed on the bottom surface of the swing column (36).

3. The artificial skin dialysis testing device for medical dermatology according to claim 1, characterized in that: The top surface of the rotating platform (3) is provided with an auxiliary component for assisting detection of the artificial skin; The auxiliary component comprises: a mounting groove (40), the mounting groove (40) is provided on the top surface of the rotating platform (3), a first ultraviolet lamp (41) is fixedly installed inside the mounting groove (40), a transparent plate (42) is fixedly installed inside the mounting groove (40), a fixing frame (43) is provided on the top surface of the rotating platform (3), a clamping frame (44) is provided on the top surface of the fixing frame (43), an illuminating groove (45) is respectively provided inside the fixing frame (43) and the clamping frame (44), a second ultraviolet lamp (46) is fixedly installed inside the illuminating groove (45), and a transparent strip (47) is fixedly sleeved inside the illuminating groove (45).

4. The artificial skin dialysis testing device for medical dermatology according to claim 3, characterized in that: The bottom surface of the clamping frame (44) is provided with a clamping component for restricting the artificial skin; The clamping assembly comprises: a connecting plate (48), the connecting plate (48) is fixedly mounted on the bottom surface of the clamping frame (44), rotating columns (49) are fixedly mounted on both sides of the connecting plate (48), a connecting frame (50) is fixedly mounted on the top surface of the fixed frame (43), rotating grooves (51) are respectively provided on both sides of the connecting frame (50), the rotating columns (49) are movably connected with the rotating grooves (51), a plurality of clamping blocks (52) are fixedly mounted on the bottom surface of the clamping frame (44), a plurality of pressing grooves (53) are provided on the top surface of the fixed frame (43), the pressing grooves (53) are movably connected with the clamping blocks (52), and the bottom surface of the clamping frame (44) is fixedly mounted. A limiting plate (54) is fixedly installed, a clamping hole (55) is provided on one side of the limiting plate (54), an operating groove (56) is provided on one side of the fixed frame (43), two operating columns (57) are provided on one side of the inner side of the operating groove (56), a spring (58) is movably sleeved on the outer circular wall of the operating column (57), a pushing block (59) is movably sleeved on the inner side of the operating groove (56), two pressing holes (60) are provided on one side of the pushing block (59), the pressing holes (60) are movably sleeved on the operating column (57), a locking block (61) is fixedly installed on one side of the pushing block (59), and the locking block (61) is movably sleeved on the clamping hole (55).

5. The artificial skin dialysis testing device for medical dermatology according to claim 3, characterized in that: The top surface of the rotating platform (3) is provided with an adjustment component for changing the position of the artificial skin; The adjustment assembly comprises: a support column (62), the support column (62) is fixedly mounted on the top surface of the rotating platform (3), a hydraulic rod (63) is fixedly mounted on one side of the support column (62), a mobile platform (64) is movably sleeved on the outside of the support column (62), a telescopic rod of the hydraulic rod (63) is fixedly mounted on the mobile platform (64), a fixed groove (66) is provided on one side of the mobile platform (64), and the interior of the fixed groove (66) is fixedly sleeved. A stepper motor (67) is provided, the driving shaft of the stepper motor (67) is fixedly mounted on the fixed frame (43), a reserved groove (70) is provided on the top surface of the base (1), a limit frame (23) is fixedly mounted on the bottom surface of the fixed plate (2), a support hole (17) is provided on the bottom surface of the limit frame (23), a servo motor (65) is fixedly sleeved inside the support hole (17), and the driving shaft of the servo motor (65) is fixedly mounted on the rotating table (3).

6. The artificial skin dialysis testing device for medical dermatology according to claim 1, characterized in that: A stabilizing hole (68) is provided on one side of the support frame (5), a fan (69) is fixedly sleeved inside the stabilizing hole (68), and a dustproof net is fixedly installed on one side of the support frame (5).

7. The artificial skin dialysis testing device for medical dermatology according to claim 2, characterized in that: A mounting frame (24) is fixedly installed inside the support frame (5), a movable hole (25) is provided on the top surface of the mounting frame (24), two sliding blocks (26) are fixedly installed on the inner circular wall surface of the movable hole (25), the adjusting column (27) is movably sleeved with the movable hole (25), two limiting grooves (28) are provided on the outer circular wall surface of the adjusting column (27), a plurality of positioning grooves (29) are provided on the outer circular wall surface of the adjusting column (27), the positioning grooves (29) are communicated with the limiting grooves (28), and the sliding blocks (26) are slidably connected with the limiting grooves (28).

8. The artificial skin dialysis testing device for medical dermatology according to claim 1, characterized in that: Two injection holes (21) are provided on the top surface of the storage box (7), and sealing plugs are movably sleeved on the inner circular walls of the injection holes (21).

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