Chinese herbal medicine hair loss preventing and hair blackening shampoo containing hair follicle targeted delivery nanoparticles and preparation method thereof

Abstract

The invention relates to the technical field of wash supplies, in particular to Chinese herbal medicine hair loss preventing and hair blackening shampoo containing hair follicle targeted delivery nanoparticles and a preparation method of the Chinese herbal medicine hair loss preventing and hair blackening shampoo. The invention discloses a skin-care lotion, which is prepared from the following components by weight: 10 to 15 g of cacumen biotae extract, 8 to 12 g of radix polygoni multiflori extract, 6 to 10 g of rhizoma zingiberis recens extract, 5 to 8 g of semen sesami nigrum extract, 3 to 5 g of chitosan, 1 to 3 g of hyaluronic acid, 0.5 to 1 g of targeting peptide, 8 to 12 g of sodium laureth sulfate, 5 to 8 g of cocamidopropyl betaine, 3 to 5 g of glycerol, 1 to 2 g of sodium chloride, 0.5 to 1 g of citric acid, 0.2 to 0.5 g of essence and 1000 ml of deionized water. Various Chinese herbal medicine extracts such as cacumen biotae, radix polygoni multiflori, fresh ginger and black sesame are carefully selected, the components have a synergistic effect, hair follicles can be fundamentally nourished, the scalp environment can be adjusted, a hair follicle targeting nanoparticle carrier is innovatively introduced, the effective components of the Chinese herbal medicines can be accurately delivered to the hair follicles by utilizing chitosan, hyaluronic acid and targeting peptide, and the effect of treating the scalp is achieved. The absorption efficiency of the active ingredients is greatly improved, so that the functional ingredients can fully play roles, and the hair loss preventing and hair blackening effects are remarkably enhanced.

Description

Technical Field

[0001] The invention relates to the technical field of toiletries, in particular to a Chinese herbal medicine anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles and a preparation method thereof. Background Art

[0002] With the accelerated pace of life, increased stress, and environmental pollution, hair loss and graying are becoming increasingly common. There are many types of anti-hair loss blackening shampoos on the market, but most have problems such as difficulty in penetrating the hair follicles with their active ingredients and limited effectiveness. Traditional Chinese herbal medicine has a long history of application in preventing hair loss and promoting hair growth, but traditional shampoos struggle to fully utilize the efficacy of these herbs. Improving the concentration and bioavailability of Chinese herbal ingredients in the hair follicles is key to developing an effective anti-hair loss blackening shampoo. To this end, a Chinese herbal anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles and a method for preparing the same are proposed. Summary of the Invention

[0003] In view of this, the present invention provides a Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles and a preparation method thereof, in order to solve or alleviate the technical problems existing in the prior art and at least provide a beneficial choice.

[0004] The technical solution of the present invention is achieved as follows: a Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles is composed of the following ingredients by weight: 10-15g of Platycladus orientalis leaf extract, 8-12g of Polygonum multiflorum extract, 6-10g of ginger extract, 5-8g of black sesame extract, 3-5g of chitosan, 1-3g of hyaluronic acid, 0.5-1g of targeting peptide, 8-12g of sodium laureth sulfate, 5-8g of cocamidopropyl betaine, 3-5g of glycerin, 1-2g of sodium chloride, 0.5-1g of citric acid, 0.2-0.5g of essence, and 1000ml of deionized water.

[0005] A method for preparing a Chinese herbal anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles comprises the following steps:

[0006] S1. Preparation of hair follicle-targeted nanoparticles;

[0007] S2, extracting effective ingredients from Chinese herbal medicines;

[0008] S3. Prepare shampoo.

[0009] Further preferably, in S1, 3-5 g of chitosan is dissolved in an appropriate amount of acetic acid solution (mass fraction 1-3%) and stirred until completely dissolved to obtain a chitosan solution. In another container, 1-3 g of hyaluronic acid is dissolved in deionized water to prepare a hyaluronic acid solution. The hyaluronic acid solution is slowly added to the chitosan solution while stirring to mix evenly. 0.5-1 g of targeting peptide is added and the reaction is continued with stirring for 1-2 hours to form a nanoparticle solution. Unreacted small molecules are removed by dialysis (dialysis bag molecular weight cutoff is 3000-5000 Da) to obtain a pure hair follicle-targeted nanoparticle solution.

[0010] Further preferably, in S2, Platycladus orientalis leaves, Polygonum multiflorum, ginger, and black sesame are taken respectively, crushed, and then added with 70% ethanol solution at a solid-liquid ratio of 1:10, and reflux extracted 2-3 times at 60-70°C, each extraction time being 1-2 hours. The extracts are combined, and ethanol is removed by reduced pressure distillation to obtain a concentrated Chinese herbal medicine extract.

[0011] Further preferably, in the S3, deionized water is added to the reactor, stirring is started, 8-12 g of sodium laureth sulfate and 5-8 g of cocamidopropyl betaine are added in sequence, and stirred until completely dissolved. 3-5 g of glycerin and 1-2 g of sodium chloride are added, and stirring is continued. The prepared hair follicle-targeted nanoparticle solution is slowly added and stirred. The concentrated Chinese herbal medicine extract is added and stirred thoroughly to mix the ingredients. The pH value is adjusted to 5.5-6.5 with 0.5-1 g of citric acid. Finally, 0.2-0.5 g of essence is added, stirred evenly, and allowed to stand for defoaming to obtain a Chinese herbal anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles.

[0012] The embodiment of the present invention adopts the above technical solution, which has the following advantages:

[0013] The present invention selects a variety of Chinese herbal extracts such as Platycladus orientalis leaves, Polygonum multiflorum, ginger, black sesame, etc. The ingredients work synergistically to nourish hair follicles from the root and regulate the scalp environment. The innovative introduction of hair follicle-targeted nanoparticle carriers, using chitosan, hyaluronic acid and targeting peptides, can accurately deliver the effective ingredients of Chinese herbal medicines to the hair follicles, greatly improving the absorption efficiency of the active ingredients, allowing the effective ingredients to play a more full role, and significantly enhancing the effect of preventing hair loss and blackening.

[0014] The above summary is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the present invention will be readily apparent by reference to the accompanying drawings and the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0016] Figure 1 Flow chart of the method of the present invention. DETAILED DESCRIPTION

[0017] Hereinafter, only certain exemplary embodiments are briefly described. As will be appreciated by those skilled in the art, the described embodiments may be modified in various ways without departing from the spirit or scope of the present invention. Therefore, the drawings and description are to be considered as illustrative in nature and not restrictive.

[0018] The embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0019] like Figure 1 As shown, an embodiment of the present invention provides a Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles, which is composed of the following ingredients by weight: 10-15g of Platycladus orientalis leaf extract, 8-12g of Polygonum multiflorum extract, 6-10g of ginger extract, 5-8g of black sesame extract, 3-5g of chitosan, 1-3g of hyaluronic acid, 0.5-1g of targeting peptide, 8-12g of sodium laureth sulfate, 5-8g of cocamidopropyl betaine, 3-5g of glycerin, 1-2g of sodium chloride, 0.5-1g of citric acid, 0.2-0.5g of flavor, and 1000ml of deionized water.

[0020] A method for preparing a Chinese herbal anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles comprises the following steps:

[0021] S1. Preparation of hair follicle-targeted nanoparticles;

[0022] S2, extracting effective ingredients from Chinese herbal medicines;

[0023] S3. Prepare shampoo.

[0024] In one embodiment, in S1, 3-5 g of chitosan is dissolved in an appropriate amount of acetic acid solution (mass fraction 1-3%) and stirred until completely dissolved to obtain a chitosan solution. In another container, 1-3 g of hyaluronic acid is dissolved in deionized water to prepare a hyaluronic acid solution. The hyaluronic acid solution is slowly added to the chitosan solution while stirring to mix evenly. 0.5-1 g of targeting peptide is added and the reaction is continued with stirring for 1-2 hours to form a nanoparticle solution. Unreacted small molecules are removed by dialysis (dialysis bag molecular weight cutoff is 3000-5000 Da) to obtain a pure hair follicle-targeted nanoparticle solution.

[0025] In one embodiment, in S2, Platycladus orientalis leaves, Polygonum multiflorum, ginger, and black sesame are taken respectively, crushed, and then added with 70% ethanol solution at a solid-liquid ratio of 1:10, and reflux extraction is carried out at 60-70°C for 2-3 times, each extraction time is 1-2 hours, the extracts are combined, and ethanol is removed by reduced pressure distillation to obtain a concentrated Chinese herbal medicine extract.

[0026] In one embodiment, in S3, deionized water is added to the reactor, stirring is started, 8-12 g of sodium laureth sulfate and 5-8 g of cocamidopropyl betaine are added in sequence, and stirred until completely dissolved. 3-5 g of glycerin and 1-2 g of sodium chloride are added, and stirring is continued. The prepared hair follicle-targeted nanoparticle solution is slowly added and stirred to mix. The concentrated Chinese herbal medicine extract is added and stirred thoroughly to mix the ingredients evenly. The pH value is adjusted to 5.5-6.5 with 0.5-1 g of citric acid. Finally, 0.2-0.5 g of essence is added, stirred evenly, and allowed to stand for defoaming to obtain a Chinese herbal anti-hair loss black hair shampoo containing hair follicle-targeted delivery nanoparticles.

[0027] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various modifications and substitutions within the technical scope disclosed in the present invention, and such modifications and substitutions are intended to be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles, characterized by: It is composed of the following ingredients by weight: 10-15g of Platycladus orientalis leaf extract, 8-12g of Polygonum multiflorum extract, 6-10g of ginger extract, 5-8g of black sesame extract, 3-5g of chitosan, 1-3g of hyaluronic acid, 0.5-1g of targeting peptide, 8-12g of sodium laureth sulfate, 5-8g of cocamidopropyl betaine, 3-5g of glycerin, 1-2g of sodium chloride, 0.5-1g of citric acid, 0.2-0.5g of flavor, and 1000ml of deionized water.

2. A method for preparing a Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles, which is used in conjunction with the Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles as claimed in claim 1, characterized in that: The following steps are involved: S1. Preparation of hair follicle-targeted nanoparticles; S2, extracting effective ingredients from Chinese herbal medicines; S3. Prepare shampoo.

3. The method for preparing the Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles according to claim 2, characterized in that: In S1, 3-5 g of chitosan is dissolved in an appropriate amount of acetic acid solution (mass fraction 1-3%) and stirred until completely dissolved to obtain a chitosan solution. In another container, 1-3 g of hyaluronic acid is dissolved in deionized water to prepare a hyaluronic acid solution. The hyaluronic acid solution is slowly added to the chitosan solution while stirring to mix evenly. 0.5-1 g of targeting peptide is added and the reaction is continued with stirring for 1-2 hours to form a nanoparticle solution. Unreacted small molecules are removed by dialysis (dialysis bag molecular weight cutoff is 3000-5000 Da) to obtain a pure hair follicle-targeted nanoparticle solution.

4. The method for preparing the Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles according to claim 2, characterized in that: In the S2, Platycladus orientalis leaves, Polygonum multiflorum, ginger, and black sesame are taken respectively, crushed, and added with 70% ethanol solution at a solid-liquid ratio of 1:10, and reflux extraction is performed at 60-70°C for 2-3 times, each extraction time is 1-2 hours, the extracts are combined, and ethanol is removed by reduced pressure distillation to obtain a concentrated Chinese herbal medicine extract.

5. The method for preparing the Chinese herbal anti-hair loss blackening shampoo containing hair follicle targeted delivery nanoparticles according to claim 3, characterized in that: In the S3, deionized water is added to the reactor, stirring is started, 8-12 g of sodium laureth sulfate and 5-8 g of cocamidopropyl betaine are added in sequence, and stirred until completely dissolved. 3-5 g of glycerin and 1-2 g of sodium chloride are added, and stirring is continued. The prepared hair follicle-targeted nanoparticle solution is slowly added and stirred to mix. The concentrated Chinese herbal medicine extract is added and stirred thoroughly to mix the ingredients evenly. The pH value is adjusted to 5.5-6.5 with 0.5-1 g of citric acid. Finally, 0.2-0.5 g of essence is added, stirred evenly, and allowed to stand for defoaming to obtain a Chinese herbal anti-hair loss blackening shampoo containing hair follicle-targeted delivery nanoparticles.

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