Whitening composition with multi-vitamin effect

Abstract

The invention relates to the technical field of external preparations for skin, in particular to a multi-vitamin whitening composition which is composed of nicotinamide, tranexamic acid, scutellaria baicalensis root extract, peony root extract and decarboxylated carnosine hydrochloride. The mass ratio of the nicotinamide to the tranexamic acid to the scutellaria baicalensis root extract to the Chinese herbaceous peony root extract to the decarboxylated carnosine hydrochloride is (1.962 to 4.038) to (1.0 to 3.0) to (0.002 to 0.007) to (0.002 to 0.013) to (0.02 to 0.08). Through specific components and proportions, bidirectional synergistic promotion of whitening components and skin conditioning components is achieved, the composition has unexpected effects of repairing, nourishing, relieving and the like on the basis of having an unexpected whitening effect, and the problems that an existing whitening product is single in effect and cannot meet requirements are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of external skin preparations, and in particular to a whitening composition with multi-dimensional functions. Background Art

[0002] As living standards improve, people are paying more attention to their appearance. More and more consumers are trying or intending to use whitening products to achieve fairer, more translucent skin, reduce skin pigmentation, and enhance their appearance. Whitening products can help reduce or slow down skin pigmentation, achieving a whitening and brightening effect.

[0003] Consumers usually face more than one skin problem. Problems such as aging and sagging skin, dry, itchy and rough skin, acne, dark and dull skin often appear together. However, the effects of whitening products are relatively single. Whitening compositions with excellent whitening, repairing, nourishing, soothing and other multi-dimensional effects are needed to meet the needs of consumers. Summary of the Invention

[0004] The object of the present invention is to provide a whitening composition that can not only improve the whitening effect, but also improve the skin repairing, nourishing, soothing and other effects.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] The present invention provides a whitening composition with multi-dimensional effects, characterized in that: the composition consists of niacinamide, tranexamic acid, scutellaria root extract, peony root extract and decarboxylic carnosine hydrochloride; the mass ratio of niacinamide:tranexamic acid:scutellaria root extract:peony root extract:decarboxylic carnosine hydrochloride is (1.962-4.038):(1.0-3.0):(0.002-0.007):(0.002-0.013):(0.02-0.08).

[0007] Furthermore, the mass ratio of niacinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride is 3:2:0.0045:0.0075:0.05.

[0008] Compared with the existing technology, the present invention achieves two-way synergistic promotion of whitening ingredients and skin conditioning ingredients through specific components and proportions. The composition of the present invention not only has unexpected whitening effects, but also has unexpected repairing, nourishing, soothing and other effects, solving the problem that existing whitening products have relatively single effects and cannot meet demand. DETAILED DESCRIPTION

[0009] The technical solutions of the present invention are further described below in conjunction with specific examples. It should be understood that the following examples are merely exemplary illustrations and explanations of the present invention and should not be construed as limiting the scope of protection of the present invention. All technologies implemented based on the above content of the present invention are encompassed within the scope that the present invention is intended to protect.

[0010] The raw materials used in the present invention are all commercially available cosmetic raw material products, among which the scutellaria root extract and the peony root extract are powdered extracts obtained by manufacturers using water extraction or other solvent extraction. This is a conventional technology in the field and will not be described in detail in the present invention.

[0011] Example 1

[0012] Example composition 1 is composed of the following proportions and ratios:

[0013] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride = 1.962:3:0.007:0.013:0.08.

[0014] Example 2

[0015] Example composition 2 is composed of the following ratios and proportions:

[0016] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride = 3:2:0.0045:0.0075:0.05.

[0017] Example 3

[0018] Example composition 3 is composed of the following ratios and proportions:

[0019] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride = 4.038:1:0.002:0.002:0.02

[0020] Comparative Example 1

[0021] Comparative composition 1 was composed of the following ratios and proportions:

[0022] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride = 1.85:2.8:0.038:0.054:0.32.

[0023] Comparative Example 2

[0024] Comparative composition 2 was composed of the following ratios and proportions:

[0025] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride = 4.03:1.02:0.001:0.001:0.01.

[0026] Comparative Example 3

[0027] Comparative composition 3 was composed of the following ratios and proportions:

[0028] Tranexamic acid: Scutellaria root extract: Paeonia lactiflora root extract: decarboxylated carnosine hydrochloride = 5.038:0.002:0.002:0.02.

[0029] Comparative Example 4

[0030] Comparative composition 4 was composed of the following ratios and proportions:

[0031] Nicotinamide: Scutellaria baicalensis root extract: Paeonia lactiflora root extract: decarboxylated carnosine hydrochloride = 5.038:0.002:0.002:0.02.

[0032] Comparative Example 5

[0033] Comparative composition 5 was composed of the following ratios and proportions:

[0034] Nicotinamide: tranexamic acid: peony root extract: decarboxylated carnosine hydrochloride = 3:2:0.009:0.053.

[0035] Comparative Example 6

[0036] Comparative composition 6 was composed of the following ratios and proportions:

[0037] Nicotinamide: tranexamic acid: scutellaria root extract: decarboxylated carnosine hydrochloride = 3:2:0.007:0.055.

[0038] Comparative Example 7

[0039] Comparative composition 7 was composed of the following ratios and proportions:

[0040] Nicotinamide: tranexamic acid: scutellaria root extract: peony root extract = 3:2:0.024:0.038.

[0041] Test Example 1: Skin Permeability Evaluation

[0042] Evaluation method: The Franz diffusion cell method was used to analyze and evaluate the penetration of the 12-hour whitening components niacinamide and tranexamic acid on the back skin of suckling pigs.

[0043] Test evaluation results: See Table 1

[0044] Table 1 Permeability results of the compositions of each group

[0045]

[0046]

[0047] As can be seen from Table 1, the composition of nicotinamide and tranexamic acid of the present invention has an unexpected penetration effect.

[0048] Experimental Example 2: Whitening Efficacy Evaluation Based on α-MSH-Induced Human Melanocyte Model

[0049] Evaluation method: The content and location of melanin are the most important factors affecting human skin color. Based on the α-MSH-induced A375 human melanocyte model, the whitening efficacy of the test sample is evaluated by detecting the changes in the melanin content of the cells after the whitening composition sample is applied.

[0050] Test evaluation results: See Table 2

[0051] Table 2 Melanin synthesis inhibition results of the compositions of each group

[0052]

[0053]

[0054] As can be seen from Table 2, the composition of the present invention has an unexpected inhibitory effect on melanin synthesis.

[0055] Experimental Example 3: Evaluation of Repair Efficacy Based on SDS-Stimulated Human Keratinocyte (HaCaT) Model

[0056] Evaluation Method: When the skin comes into contact with irritants, it will damage the skin barrier, leading to dryness and erythema. Sodium dodecyl sulfate (SDS) is a commonly used surfactant. When exposed to the skin at high concentrations, it can damage the skin barrier, especially the lipid components and barrier-related proteins in the barrier.

[0057] Transmembrane proteins (Claudin-1) and tight junction proteins (ZO-1) are components of the tight junction structure of the skin barrier. They mainly maintain the stability and integrity of intercellular connections and are important factors in maintaining skin barrier function. Analysis of these proteins can reflect the sample's repair effect on the skin barrier. This experiment is based on the SDS-stimulated human keratinocyte (HaCaT) model. By detecting changes in Claudin-1 and ZO-1 gene expression levels after the whitening composition sample is applied, the repair efficacy of the test sample is evaluated.

[0058] Test evaluation results: See Table 3

[0059] Table 3 The results of promoting Claudin-1 and ZO-1 by the compositions of each group

[0060]

[0061]

[0062] It can be seen from Table 3 that the composition of the present invention has an unexpected promoting effect on the expression of Claudin-1 and ZO-1 genes.

[0063] Experimental Example 4: Evaluation of Nourishing Function Based on Human Keratinocyte (HaCaT) Model

[0064] Evaluation method: The intercellular lipid structure of the stratum corneum is mainly composed of 50% ceramide, 25% cholesterol, 15% free fatty acids, 5% cholesterol esters and 5% cholesterol esters. These lipids are mainly converted from glucosylceramide phospholipids, glycerophospholipids and cholesterol sulfate under the action of various lipid synthases. The increase in lipid content can provide nourishing effect for the skin. Serine palmitoyl transferase (SPT) is the rate-limiting enzyme for ceramide synthesis and can promote ceramide synthesis. Trihydroxymethylglutaryl-CoA Reductase (HMGCoA) is the main synthase for cholesterol and can promote cholesterol synthesis. The nourishing effect of the test sample is evaluated by detecting the changes in SPT and HMGCoA gene expression after the whitening composition sample is exposed to the action of the whitening composition sample.

[0065] Test evaluation results: See Table 4

[0066] Table 4 Results of the compositions in each group promoting the expression of SPT and HMGCoA genes

[0067]

[0068]

[0069] It can be seen from Table 4 that the composition of the present invention has an unexpected promoting effect on the expression of SPT and HMGCoA genes.

[0070] Test Example 5: Soothing Effect Evaluation Based on Human Keratinocyte (HaCaT) Model

[0071] Evaluation Method: Keratinocytes are the primary cell type that makes up the epidermis. When stimulated by UVB, they increase the production of inflammatory factors like IL-8 and TNF-a, triggering a series of skin stress reactions. The soothing efficacy of the whitening composition samples was evaluated by measuring changes in IL-8 and TNF-a gene expression after application.

[0072] Test evaluation results: see Table 5

[0073] Table 5 Results of the effects of each group of compositions on the expression of IL-8 and TNF-a genes

[0074]

[0075]

[0076] As can be seen from Table 5, the composition of the present invention has an unexpected inhibitory effect on the expression of IL-8 and TNF-a genes.

[0077] Although the specific embodiments of the present invention are described above, those skilled in the art should understand that the specific embodiments described are merely illustrative and are not intended to limit the scope of the present invention. Any modifications and changes made by those skilled in the art in accordance with the spirit of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A multi-functional whitening composition, characterized in that The composition consists of niacinamide, tranexamic acid, scutellaria root extract, peony root extract and decarboxylic carnosine hydrochloride; the mass ratio of niacinamide:tranexamic acid:scutellaria root extract:peony root extract:decarboxylic carnosine hydrochloride is (1.962-4.038):(1.0-3.0):(0.002-0.007):(0.002-0.013):(0.02-0.08).

2. A multi-functional whitening composition according to claim 1, characterized in that The mass ratio of niacinamide: tranexamic acid: scutellaria root extract: peony root extract: decarboxylated carnosine hydrochloride is 3:2:0.0045:0.0075:0.05.

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