Device and method for preparing chloroquine nanoparticle medicine

Abstract

The invention discloses a device and method for preparing chloroquine nano-particle medicine, and relates to the technical field of chloroquine nano-particle medicine preparation, and the device comprises a nitrogen tank, a first storage tank, a first pipeline, a second pipeline, a third pipeline, a pressure flash tank, a spraying device, a condenser, a centrifugal machine, a dryer and a fourth pipeline; the nitrogen tank is communicated with the pressure flash tank while being communicated with the first storage tank; the first storage tank is used for placing a chloroquine acetone solution and is communicated with the pressure flash tank; the spraying device is arranged in the pressure flash tank, and the spraying device sprays and flashes the chloroqualinone solution to form flash gas; the pressure flash tank is communicated with the condenser, the condenser cools flash gas into a mixture of liquid acetone and chloroquine nanoparticles, the centrifugal machine can separate the mixture of liquid acetone and chloroquine nanoparticles, and the drying box can dry chloroquine nanoparticles. The preparation system has the advantages that the structure is simple, operation is convenient, cost is saved, and the preparation speed is effectively increased.

Description

Technical Field

[0001] The present invention relates to the technical field of nanoparticle drug preparation, in particular to a device and method for preparing chloroquine nanoparticle drugs. Background Art

[0002] Chloroquine is a widely used antimalarial and anti-inflammatory drug, but its traditional form suffers from low solubility, limited bioavailability, and insufficient targeting. To overcome these limitations, the preparation of chloroquine nanoparticles has become a highly sought-after method. Nanoparticles can improve the dissolution rate and bioavailability of chloroquine after oral administration by increasing solubility and surface area. Furthermore, nanoparticles can enable targeted drug delivery, precisely delivering the drug to the site of disease, reducing damage to healthy tissue, and enhancing the drug's efficacy. Furthermore, through appropriate preparation methods and material selection, nanoparticles can control the drug's release rate, prolong the drug's duration of action, reduce dosing frequency, and improve patient convenience and compliance. Traditional methods for preparing chloroquine primarily include solvent deposition and sol-gel methods, but these methods are complex and costly.

[0003] Therefore, there is an urgent need for a device and method for preparing chloroquine nanoparticle drugs that is simple to operate and low in cost. Summary of the Invention

[0004] The purpose of the present invention is to provide a device and method for preparing chloroquine nanoparticle medicine, so as to solve the problems existing in the above-mentioned technology, thereby achieving the purpose of simplifying structure and operation, improving preparation speed and saving cost.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] The present invention provides a device for preparing chloroquine nanoparticle medicine, comprising: a high-pressure working section and a normal-pressure working section, wherein the high-pressure working section comprises a nitrogen tank, a first storage tank, a flow meter, a first constant-temperature heating device, a flow regulating valve, a first pressure transmitter, a first thermocouple, a first pipeline, a second pipeline and a third pipeline; the normal-pressure working section comprises a pressure flash tank, a spray device, a second constant-temperature heating device, a centrifugal pump, a condenser, a centrifuge, a dryer and a fourth pipeline; the nitrogen tank is connected to the first storage tank through the first pipeline to provide pressure to the high-pressure working section, and the nitrogen tank is connected to the pressure flash tank through the third pipeline to condense the pressure. The normal pressure working section is filled with nitrogen to form an inert atmosphere; the first storage tank is used to place the chloroquine acetone solution, and the top of the first storage tank is connected to and communicated with the first pipeline, and the bottom of the first storage tank is connected to and communicated with the pressure flash tank through the third pipeline; the flow meter, the first constant temperature heating device, the flow regulating valve, the pressure transmitter and the first thermocouple are arranged on the second pipeline, the flow meter is used to measure the flow of the chloroquine acetone solution in the second pipeline, the first thermocouple is used to measure the temperature of the chloroquine acetone solution in the second pipeline, and the first pressure transmitter is used to measure the pressure of the chloroquine acetone solution in the second pipeline. The pressure of the chloroquine acetone solution, the flow regulating valve is used to regulate the flow of the chloroquine acetone solution in the second pipeline, and the first constant temperature heating device is used to heat the chloroquine acetone solution in the second pipeline; the spray device is arranged in the pressure flash tank, one end of the spray device extends out of the pressure flash tank and is connected and communicated with the second pipeline, and the spray device is used to introduce the chloroquine acetone solution transported by the second pipeline into the pressure flash tank and realize spray flash evaporation to form flash gas; the pressure flash tank is communicated with the condenser through the fourth pipeline, and the second constant temperature heating device and the centrifugal pump are arranged in On the fourth pipeline, the second constant temperature heating device is used to heat the flash gas in the fourth pipeline, the centrifugal pump is used to provide the required circulation power for the normal pressure working section, the condenser is used to cool the flash gas entering the condenser into a mixture of liquid acetone and chloroquine nanoparticles, and the liquid collector is connected to the condenser to collect the liquid acetone and chloroquine nanoparticle mixture; the centrifuge can separate the liquid acetone and chloroquine nanoparticle mixture placed in the centrifuge and collect the chloroquine nanoparticles, and the drying oven is used to dry the chloroquine nanoparticles.

[0007] Preferably, the system further comprises a first filter, wherein the first filter is arranged on the second pipe.

[0008] Preferably, it further comprises a second storage tank and a fifth pipeline, the top end of the second storage tank is connected to the nitrogen tank through the fifth pipeline, and the bottom end of the second storage tank is connected to the second pipeline.

[0009] Preferably, it further includes a second thermocouple and a second pressure transmitter, the pressure flash tank is provided with a thermocouple nozzle and a pressure transmitter nozzle, the second thermocouple is provided at the thermocouple nozzle to measure the temperature inside the pressure flash tank, and the second pressure transmitter is provided at the pressure transmitter nozzle to measure the pressure inside the pressure flash tank.

[0010] Preferably, it further comprises a liquid storage tank and a sixth pipeline, wherein the liquid storage tank is connected to the bottom of the pressure flash tank through the sixth pipeline to collect the liquid generated at the bottom of the pressure flash tank.

[0011] Preferably, the system further comprises a second filter, wherein the second filter is arranged on the sixth pipe.

[0012] Preferably, the spray device includes a liquid inlet main pipe, four groups of nozzles and four connecting branches, one end of the liquid inlet main pipe passes through the pressure flash tank and is connected and communicated with the second pipeline, each of the connecting branches is connected and communicated with one end of the liquid inlet main pipe extending into the pressure flash tank, and each of the connecting branches is provided with a nozzle at one end away from the liquid inlet main pipe, and each of the connecting branches is horizontally and evenly arranged in the circumferential direction of the liquid inlet main pipe.

[0013] Preferably, the nozzle is a hollow high-pressure cone atomizing nozzle.

[0014] Preferably, it also includes a first valve, a second valve, a third valve, a fourth valve, a fifth valve, a sixth valve, a seventh valve and an eighth valve, wherein the first valve is arranged on the first pipeline, the second valve is arranged on the second pipeline, the third valve is arranged on the third pipeline, and the fourth valve is arranged on the fourth pipeline.

[0015] The present invention also provides a method for preparing chloroquine nanoparticle medicine using the chloroquine nanoparticle medicine preparation device as described above, comprising the following steps:

[0016] The nitrogen tank delivers nitrogen to the pressure flash tank through the third pipeline, the centrifugal pump is turned on, and the air in the pressure flash tank is discharged by the nitrogen to form an inert atmosphere. Hexadecanoic acid is added to the saturated chloroquine acetone solution and then added to the first storage tank. The first constant temperature heating device is turned on to heat the second pipeline, and the second constant temperature heating device is turned on to heat the fourth pipeline. The nitrogen tank pressurizes the first storage tank, and the flow regulating valve is opened to adjust the pressure and flow so that the saturated chloroquine acetone solution is sprayed into the pressure flash tank through the spray device, spray flash occurs and forms flash gas, and the flash gas flows into the condenser under the driving action of the centrifugal pump. After the flash gas is cooled in the condenser, it flows out of the liquid acetone and nano-chloroquine particle mixture and enters the liquid collector. The liquid acetone and nano-chloroquine particle mixture in the liquid collector is placed in the centrifuge for centrifugation to obtain the required chloroquine particle mixed solution through the action of centrifugal force. The obtained chloroquine particle mixed solution is placed in a drying oven for drying, and finally the required chloroquine nanoparticles are obtained.

[0017] Compared with the prior art, the present invention has achieved the following technical effects:

[0018] The invention provides a device and method for preparing chloroquine nanoparticle medicine. The device comprises the following steps: a nitrogen tank transports nitrogen into a pressure flash tank through a third pipeline; a centrifugal pump is turned on to discharge air in the pressure flash tank through the nitrogen to form an inert atmosphere; hexadecanoic acid is added to a saturated chloroquine acetone solution and then the solution is added to a first storage tank; a first constant temperature heating device is turned on to heat a second pipeline; a second constant temperature heating device is turned on to heat a fourth pipeline; the nitrogen tank pressurizes the first storage tank; a flow regulating valve is opened to regulate pressure and flow; the saturated chloroquine acetone solution is sprayed into the pressure flash tank through a spray device; spray flash evaporation occurs and flash gas is formed; the flash gas flows into a condenser driven by the centrifugal pump; the flash gas is cooled in the condenser and then flows out as a mixture of liquid acetone and nano-chloroquine particles into a liquid collector; the liquid acetone and nano-chloroquine particle mixture in the liquid collector is placed in a centrifuge for centrifugation; a desired chloroquine particle mixed solution is obtained by the action of centrifugal force; the obtained chloroquine particle mixed solution is placed in a drying oven for drying, and finally the desired chloroquine nanoparticles are obtained. The above preparation system has the advantages of simple structure, convenient operation, cost saving, and effective improvement of preparation speed.

[0019] By this set of equipment, nanoparticles can be quickly separated and collected from solution, which makes the chloroquine nanoparticles prepared have higher purity, reducing the step and cost of subsequent treatment. By flash distillation, instantaneous evaporation is realized, and solution is rapidly changed into gaseous state in the very short time, thereby forming nanoparticles. Compared with traditional preparation methods, the nanoparticles prepared by the present invention have faster preparation speed and high efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive effort.

[0021] Figure 1 A schematic structural diagram of a device for preparing chloroquine nanoparticle drugs provided by the present invention;

[0022] Figure 2 This is a schematic structural diagram of the pressure flash tank in the device for preparing chloroquine nanoparticle drugs provided by the present invention;

[0023] Figure 3 A top cross-sectional view of a pressure flash tank in the device for preparing chloroquine nanoparticle drugs provided by the present invention;

[0024] In the figure: 1. Nitrogen tank; 2. First storage tank; 3. Second storage tank; 4. First valve; 5. First filter; 6. Flowmeter; 7. First constant temperature heating device; 8. Flow regulating valve; 9. First pressure transmitter; 10. First thermocouple; 11. Pressure flash tank; 12. Spray device; 13. Second constant temperature heating device; 14. Second filter; 15. Centrifugal pump; 16. Liquid storage tank; 17. Condenser; 18. Liquid collector; 19. Centrifuge; 20. Drying oven. 21. First pipeline; 22. Second pipeline; 23. Third pipeline; 24. Fourth pipeline; 25. Fifth pipeline; 26. Sixth pipeline; 27. Ninth valve; 28. Second valve; 29. ​​Third valve; 30. Fourth valve; 31. Fifth valve; 32. Sixth valve; 33. Seventh valve; 34. Eighth valve; 35. Liquid inlet main pipe; 36. Nozzle; 37. Connecting branch pipe; 38. Second thermocouple; 39. Second pressure transmitter; 40. Tenth valve. DETAILED DESCRIPTION

[0025] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0026] The present invention aims to provide a device and method for preparing chloroquine nanoparticle medicine, so as to solve the problems existing in the above-mentioned prior art, with simple structure, convenient operation, effective improvement of preparation speed and cost saving.

[0027] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0028] Example 1:

[0029] This embodiment provides a device for preparing chloroquine nanoparticles, such as Figures 1 to 3 As shown, it includes: a high-pressure working section and a normal-pressure working section. The high-pressure working section includes a nitrogen tank 1, a first storage tank 2, a flow meter 6, a first constant-temperature heating device 7, a flow regulating valve 8, a first pressure transmitter 9, a first thermocouple 10, a first pipeline 21, a second pipeline 22 and a third pipeline 23; the normal-pressure working section includes a pressure flash tank 11, a spray device 12, a second constant-temperature heating device 13, a centrifugal pump 15, a condenser 17, a centrifuge 19, a dryer and a fourth pipeline 24; the nitrogen tank 1 is connected to the first storage tank 2 through the first pipeline 21 to provide pressure to the high-pressure working section, and the nitrogen tank 1 is connected to the pressure through the third pipeline 23. Flash tank 11 is communicated with to normal pressure working section filling nitrogen and forming inert atmosphere; First storage tank 2 is used for placing chloroquine acetone solution, and the top of the first storage tank 2 is connected and communicated with the first pipeline 21, and the bottom of the first storage tank 2 is connected and communicated with the pressure flash tank 11 by the third pipeline 23; Flow meter 6, the first constant temperature heating device 7, the flow regulating valve 8, the first pressure transmitter 9 and the first thermocouple 10 are arranged on the second pipeline 22, and flow meter 6 is used to measure the flow of chloroquine acetone solution in the second pipeline 22, and the first thermocouple 10 is used to measure the temperature of chloroquine acetone solution in the second pipeline 22, and the first pressure transmitter 9 is used to measure the pressure of chloroquine acetone solution in the second pipeline 22. The pressure of chloroquine acetone solution in the second pipeline 22 is measured, and flow regulating valve 8 is used for regulating the flow of chloroquine acetone solution in the second pipeline 22, and the first constant temperature heating device 7 is used for heating chloroquine acetone solution in the second pipeline 22; Spraying device 12 is arranged in the pressure flash tank 11, and one end of spraying device 12 stretches out pressure flash tank 11 and is connected and communicated with the second pipeline 22, and spraying device 12 is used for the chloroquine acetone solution that the second pipeline 22 is carried to is imported in the pressure flash tank 11 and realizes spraying flash to form flash gas; Pressure flash tank 11 is communicated with condenser 17 by the 4th pipeline 24, and the second constant temperature heating device 13 and The centrifugal pump 15 is provided on the fourth pipeline 24. The second constant temperature heating device 13 is used to heat the flash gas in the fourth pipeline 24. The centrifugal pump 15 is used to provide the required circulation power for the normal pressure working section. The condenser 17 is used to cool the flash gas entering the condenser 17 into a mixture of liquid acetone and chloroquine nanoparticles. The liquid collector 18 is connected to the condenser 17 to collect the mixture of liquid acetone and chloroquine nanoparticles. The centrifuge 19 can separate the liquid acetone and chloroquine nanoparticles placed in the centrifuge 19 and collect the chloroquine nanoparticles. The drying oven 20 is used to dry the chloroquine nanoparticles.

[0030] Nitrogen tank 1 carries nitrogen by the 3rd pipeline 23 in pressure flash tank 11, open centrifugal pump 15, by nitrogen the air in the pressure flash tank 11 is discharged, form inert atmosphere, add after adding hexadecanoic acid in saturated chloroquine acetone solution in the first storage tank 2, open the first constant-temperature heating device 7 and heat the second pipeline 22, open the second constant-temperature heating device 13 and heat the 4th pipeline 24, nitrogen tank 1 is pressurized in the first storage tank 2, open flow regulating valve 8 and carry out the regulating of pressure and flow, make saturated chloroquine acetone solution spray into pressure flash tank 11 through spraying device 12, spray occurs Mist flash evaporation also forms flash gas, flash gas flows into condenser 17 under the driving force of centrifugal pump 15, flash gas flows out liquid acetone and nanometer chloroquine particle mixture after cooling in condenser 17 and enters into liquid collector 18, liquid acetone in liquid collector 18 and nanometer chloroquine particle mixture are put into centrifuge 19 and are centrifuged, by centrifugal force effect, the chloroquine particle mixed solution needed is obtained, the chloroquine particle mixed solution obtained is put into drying box 20 and is dried, finally obtain the chloroquine nanoparticles needed, this device is simple in structure, easy to operate, can effectively improve preparation speed, save cost.Can by this set of equipment, nanoparticle is quickly separated and collected from solution, this makes the chloroquine nanoparticles prepared have higher purity, reduce step and the cost of subsequent treatment, compared traditional preparation method, the nanoparticles prepared by the present invention has faster preparation speed and high efficiency.

[0031] In the preferred embodiment of the present invention, the device for preparing chloroquine nanoparticle medicine further comprises a first filter 5. The first filter 5 is arranged on the second pipeline 22 to prevent impurities from entering the spray chamber from the second pipeline 22, thereby ensuring the purity of the solution in the loop.

[0032] In a preferred embodiment of the present invention, the device for preparing chloroquine nanoparticles further includes a second storage tank 3 and a fifth pipeline 25. The top of the second storage tank 3 is connected to the nitrogen tank 1 via the fifth pipeline 25, and the bottom of the second storage tank 3 is connected to the second pipeline 22. The second storage tank 3 is used to store the acetone solution. After the solution in the liquid collector 18 and the liquid storage tank 16 is removed, the nitrogen tank 1 pressurizes the second storage tank 3, uses the acetone solution to clean the second pipeline 22 and the spray device 12, and cleans the pressure flash tank 11.

[0033] In the preferred version of the present embodiment, the device of producing chloroquine nano particle medicine also comprises the second thermocouple 38 and the second pressure transmitter 39.Pressure flash tank 11 is provided with thermocouple mouth and pressure transmitter mouth, the second thermocouple 38 is arranged at the thermocouple mouth to measure the temperature in the pressure flash tank 11, the second pressure transmitter 39 is arranged at the pressure transmitter mouth to measure the pressure in the pressure flash tank 11, this device can utilize spray flash evaporation principle, chloroquine solution is introduced in the pressure flash tank device by spraying mode, flash evaporation process is generated in liquid when the transient change of experience pressure, one of the generation condition of flash evaporation is the sudden reduction of liquid experience pressure, causes the saturation temperature of liquid to be lower than its initial temperature.In the present application, the design and operation control of flash evaporation unit makes chloroquine solution spray in the device under suitable conditions, the sudden reduction of liquid experience pressure, thereby causes flash evaporation process. Through flash evaporation, the chloroquine solution is rapidly converted into a gaseous state under superheated conditions to form chloroquine nanoparticles. The second thermocouple 38 and the second pressure transmitter 39 can measure the temperature and pressure in the pressure flash tank 11, so that the flash evaporation conditions are met in the pressure flash tank 11, thereby triggering flash evaporation.

[0034] In a preferred embodiment of the present invention, the device for preparing chloroquine nanoparticles further includes a liquid storage tank 16 and a sixth pipeline 26. The liquid storage tank 16 is connected to the bottom of the pressure flash tank 11 through the sixth pipeline 26 to collect the liquid generated at the bottom of the pressure flash tank 11.

[0035] In a preferred embodiment of the present invention, the device for preparing chloroquine nanoparticles further comprises a second filter 14. The second filter 14 is configured to be disposed on the sixth pipeline 26 and to prevent impurities from entering the liquid storage tank 16 through the sixth pipeline 26, thereby ensuring the purity of the solution entering the centrifuge 19.

[0036] In a preferred embodiment of this invention, the spray device 12 includes a liquid inlet manifold 35, four sets of nozzles 36, and four connecting branches 37. One end of the liquid inlet manifold 35 passes through the pressure flash tank 11 and is connected to and communicates with the second pipeline 22. Each connecting branch 37 is connected to and communicates with the end of the liquid inlet manifold 35 extending into the pressure flash tank 11. Each connecting branch 37 is provided with a nozzle 36 at the end away from the liquid inlet manifold 35. The connecting branches 37 are arranged horizontally and evenly in the circumferential direction of the liquid inlet manifold 35 to effectively ensure the spray efficiency and uniformity of the nozzles 36.

[0037] In a preferred embodiment of the present invention, the nozzle 36 is a hollow high-pressure conical atomizing nozzle 36 , which can atomize the solution at an angle of 30 to 150 degrees.

[0038] In a preferred embodiment of the present invention, a first valve 4, a second valve 28, a third valve 29, a fourth valve 30, a fifth valve 31, a sixth valve 32, a seventh valve 33, and an eighth valve 34 are further included. The first valve 4 is disposed on the first pipeline 21, the second valve 28 is disposed on the second pipeline 22, the third valve 29 is disposed on the third pipeline 23, the fourth valve 30 is disposed on the fourth pipeline 24, the fifth valve 31 is disposed on the fifth pipeline 25, the sixth valve 32 is disposed on the sixth pipeline 26, the seventh valve 33 is disposed between the second storage tank 3 and the second pipeline 22, and one end of the eighth valve 34 is connected to the pipeline between the condenser 17 and the liquid collector 18, and the other end is connected to the outside.

[0039] In the preferred solution of this embodiment, a ninth valve 27 and a tenth valve 40 are further included. The ninth valve 27 is arranged at the liquid inlet on the top of the first storage tank 2 , and the tenth valve 40 is arranged at the liquid inlet on the top of the second storage tank 3 .

[0040] Example 2:

[0041] This embodiment also provides a method for preparing chloroquine nanoparticles using the chloroquine nanoparticles preparation device of embodiment 1, comprising the following steps:

[0042] Open the 3rd valve 29, the 4th valve 30 and the 8th valve 34, nitrogen tank 1 carries nitrogen by the 3rd pipeline 23 in the pressure flash tank 11, open centrifugal pump 15, by nitrogen the air in the pressure flash tank 11 is discharged, form inert atmosphere, open the 9th valve 27 and add after adding hexadecanoic acid in the saturated chloroquine acetone solution in the first storage tank 2, open the first constant-temperature heating device 7 and heat the second pipeline 22, open the second constant-temperature heating device 13 and heat the 4th pipeline 24, close the 9th valve 27, the 3rd valve 29 and the 8th valve 34, open the second valve 28 and the first valve 4, nitrogen tank 1 is pressurized in the first pair of storage tanks 2, open flow regulating valve 8 and carry out the regulating of pressure and flow, make saturated chloroquine acetone solution The ketone solution is sprayed into the pressure flash tank 11 through the spray device 12, spray flash occurs and flash gas is formed. The flash gas flows into the condenser 17 under the driving action of the centrifugal pump 15. After the flash gas is cooled in the condenser 17, it flows out of the liquid acetone and nano-chloroquine particle mixture and enters the liquid collector 18. The sixth valve 32 is opened to allow the liquid at the bottom of the pressure flash tank 11 to pass through the second filter device and then enter the liquid storage tank 16. The liquid acetone and nano-chloroquine particle mixture in the liquid storage tank 16 and the liquid collector 18 is placed in the centrifuge 19 for centrifugation. The desired chloroquine particle mixed solution is obtained by the action of centrifugal force. The obtained chloroquine particle mixed solution is placed in the drying oven 20 for drying, and finally the desired chloroquine nanoparticles are obtained.

[0043] Close the first valve 4 and the second valve 28, open the fifth valve 31 and the seventh valve 33, and apply pressure to the acetone solution in the second tank body by the nitrogen tank 1. Use the acetone solution to clean the second pipe 22 and the nozzle 36, and clean the pressure flash tank 11.

[0044] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A device for preparing chloroquine nanoparticle medicine, characterized in that, Including high pressure working section and normal pressure working section; The high-pressure working section includes: a nitrogen tank, a first storage tank, a flow meter, a first constant temperature heating device, a flow regulating valve, a first pressure transmitter, a first thermocouple, a first pipeline, a second pipeline and a third pipeline; The normal pressure working section includes: a pressure flash tank, a spray device, a second constant temperature heating device, a centrifugal pump, a condenser, a centrifuge, a dryer and a fourth pipeline; The nitrogen tank is connected to the first storage tank through the first pipeline to provide pressure to the high-pressure working section; the nitrogen tank is connected to the pressure flash tank through the third pipeline to fill the normal-pressure working section with nitrogen and form an inert atmosphere; The first storage tank is used to place chloroquine acetone solution, and the top of the first storage tank is connected and communicated with the first pipeline; the bottom of the first storage tank is connected and communicated with the pressure flash tank through the third pipeline; Described flow meter, described first constant temperature heating device, described flow regulating valve, described pressure transmitter and described first thermocouple are arranged on the second pipeline; Described flow meter is used for measuring the flow of chloroquine acetone solution described in the second pipeline, described first thermocouple is used for measuring the temperature of chloroquine acetone solution described in the second pipeline, described first pressure transmitter is used for measuring the pressure of chloroquine acetone solution described in the second pipeline, described flow regulating valve is used for regulating the flow of chloroquine acetone solution described in the second pipeline, and described first constant temperature heating device is used for heating chloroquine acetone solution described in the second pipeline; The spray device is arranged in the pressure flash tank, one end of which extends out of the pressure flash tank and is connected to and communicated with the second pipeline, and the spray device is used to introduce the chloroquine acetone solution transported by the second pipeline into the pressure flash tank and realize spray flash evaporation to form flash gas; The pressure flash tank is communicated with the condenser via the fourth pipeline; the second constant temperature heating device and the centrifugal pump are disposed on the fourth pipeline; the second constant temperature heating device is used to heat the flash gas in the fourth pipeline; the centrifugal pump is used to provide the required circulation power for the normal pressure working section; the condenser is used to cool the flash gas entering therein into a mixture of liquid acetone and chloroquine nanoparticles; the liquid collector is communicated with the condenser to collect the mixture of liquid acetone and chloroquine nanoparticles; The centrifuge can separate the liquid acetone and the chloroquine nanoparticle mixture placed therein and collect the chloroquine nanoparticles, and the drying box is used to dry the chloroquine nanoparticles.

2. the device of producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: A first filter is included, and the first filter is arranged on the second pipe.

3. the device of producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: It includes a second storage tank and a fifth pipeline. The top end of the second storage tank is connected to the nitrogen tank through the fifth pipeline, and the bottom end of the second storage tank is connected to the second pipeline.

4. the device for producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: It includes a second thermocouple and a second pressure transmitter. The pressure flash tank is provided with a thermocouple nozzle and a pressure transmitter nozzle. The second thermocouple is provided at the thermocouple nozzle to measure the temperature inside the pressure flash tank. The second pressure transmitter is provided at the pressure transmitter nozzle to measure the pressure inside the pressure flash tank.

5. the device for producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: It includes a liquid storage tank and a sixth pipeline. The liquid storage tank is connected with the bottom of the pressure flash tank through the sixth pipeline to collect the liquid generated at the bottom of the pressure flash tank.

6. the device for producing chloroquine nanoparticle medicine according to claim 5, is characterized in that: A second filter is included, and the second filter is arranged on the sixth pipe.

7. the device for producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: The spray device includes a liquid inlet main pipe, four groups of nozzles and four connecting branches. One end of the liquid inlet main pipe passes through the pressure flash tank and is connected and communicated with the second pipeline. Each of the connecting branches is connected and communicated with one end of the liquid inlet main pipe extending into the pressure flash tank. Each of the connecting branches is provided with a nozzle at one end away from the liquid inlet main pipe. Each of the connecting branches is horizontally and evenly arranged in the circumferential direction of the liquid inlet main pipe.

8. the device for producing chloroquine nanoparticle medicine according to claim 7, is characterized in that: The nozzle is a hollow high-pressure cone atomizing nozzle.

9. the device for producing chloroquine nanoparticle medicine according to claim 1, is characterized in that: It includes a first valve, a second valve, a third valve, a fourth valve, a fifth valve, a sixth valve, a seventh valve and an eighth valve, wherein the first valve is arranged on the first pipeline, the second valve is arranged on the second pipeline, the third valve is arranged on the third pipeline, and the fourth valve is arranged on the fourth pipeline.

10. A method for preparing chloroquine nanoparticles using the device for preparing chloroquine nanoparticles as claimed in any one of claims 1 to 9, comprising the following steps: Described nitrogen tank is carried nitrogen in described pressure flash tank by described the 3rd pipeline, open described centrifugal pump, by described nitrogen, the air in described pressure flash tank is discharged, form inert atmosphere, after adding hexadecanoic acid in saturated chloroquine acetone solution, add in described first storage tank, open described first constant-temperature heating device and heat described second pipeline, open described second constant-temperature heating device and heat described 4th pipeline.Described nitrogen tank is pressurized in described first storage tank, open described flow regulating valve and carry out the regulation of pressure and flow, described saturated chloroquine acetone solution is sprayed into described pressure flash tank through described spraying device, spray flash occurs and form flash gas, described flash gas flows into described condenser under the driving effect of described centrifugal pump, and described flash gas flows out liquid acetone and nanometer chloroquine particle mixture after cooling in described condenser and enters described liquid collector. The liquid acetone and nano-chloroquine particle mixture in the liquid collector is placed in the centrifuge for centrifugation, and the required chloroquine particle mixed solution is obtained by the action of centrifugal force. The obtained chloroquine particle mixed solution is placed in a drying oven for drying, and finally the required chloroquine nanoparticles are obtained.

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