Sensitive skin repairing cream containing salicylic acid and centella asiatica extract and preparation method of sensitive skin repairing cream

Abstract

The invention relates to the field of daily chemicals, in particular to sensitive skin repairing cream containing salicylic acid and centella asiatica extract and a preparation method of the sensitive skin repairing cream, and the IPC classification number is A61K8. The repairing cream is prepared from the following raw materials: water, grease, a humectant, salicylic acid, a skin conditioner, an emulsifier, a thickener, a preservative and a chelating agent. Wherein the skin conditioner comprises centella asiatica extract, cryptomeria fortunei leaf extract, sweet wormwood herb extract and verbena leaf extract. The prepared repairing cream is excellent in stability, has an efficient skin repairing effect, and also has relatively good anti-oxidation and anti-aging effects.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, in particular to a sensitive skin repair cream containing salicylic acid and Centella asiatica extract and a preparation method thereof, with IPC classification number A61K8. Background Art

[0002] Sensitive skin repair cream is mainly used to solve the problems of fragile skin, easy redness, dryness or damaged skin barrier. The functions of this type of cream often include: soothing and anti-allergic: relieve burning, stinging, itching and other discomforts; repair barrier: strengthen the skin's stratum corneum, improve water retention ability, and reduce external stimuli; moisturizing and stabilizing: replenish moisture and lipids to maintain the skin's stable state; anti-inflammatory and redness-reducing: reduce redness and inflammatory reactions caused by sensitivity (such as rosacea, seborrheic dermatitis), etc.

[0003] The ingredients in common sensitive skin repair creams include: ceramide: replenishes intercellular lipids and repairs physical barriers; squalane: simulates the structure of the sebum membrane and enhances water-locking protection; Centella asiatica extract (B5, asiatica glycoside): promotes wound healing and relieves inflammation; hyaluronic acid / panthenol (B5): deeply moisturizes and relieves dryness and tightness; purslane and chamomile: natural anti-allergic ingredients that reduce irritation reactions; probiotics / oat extract: regulates skin microecology and enhances resistance.

[0004] There are numerous sensitive skin repair creams on the market, but their effectiveness varies widely. Furthermore, relatively few studies have examined sensitive skin repair creams containing salicylic acid and Centella asiatica extract. Therefore, there is a need to provide a sensitive skin repair cream containing salicylic acid and Centella asiatica extract with enhanced efficacy. Summary of the Invention

[0005] The technical solution of the present invention is proposed to solve the above technical problems. The solution of the present invention relates to the field of daily chemicals and includes a sensitive skin repair cream containing salicylic acid and Centella asiatica extract and a preparation method thereof.

[0006] The invention provides a sensitive skin repair cream containing salicylic acid and Centella asiatica extract. The raw materials are: water, oil, moisturizer, salicylic acid, skin conditioner, emulsifier, thickener, preservative and chelating agent.

[0007] Preferably, the skin conditioning agent includes Centella asiatica extract, Cryptomeria japonica leaf extract, Artemisia annua extract, and Verbena officinalis leaf extract.

[0008] Preferably, the sensitive skin repair cream containing salicylic acid and Centella asiatica extract comprises the following raw materials, in parts by weight: 50-100 parts of water, 2-5 parts of oil, 3-7 parts of moisturizer, 0.05-0.25 parts of salicylic acid, 1.2-3.2 parts of skin conditioner, 1-3 parts of emulsifier, 0.5-2 parts of thickener, 0-0.2 parts of preservative, and 0-0.5 parts of chelating agent.

[0009] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the skin conditioners include 0.3-0.8 parts of Centella asiatica extract, 0.3-0.8 parts of Cryptomeria japonica leaf extract, 0.3-0.8 parts of Artemisia annua extract and 0.3-0.8 parts of Verbena officinalis leaf extract.

[0010] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the oil includes at least one of castor oil fatty acid methyl ester, oleyl oleate, cetostearyl alcohol, polydimethylsiloxane, caprylic / capric glyceride, squalane, and isohexadecane.

[0011] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the moisturizer includes at least one of polyols, hyaluronic acid and derivatives thereof.

[0012] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the emulsifier includes at least one of Tween, ceteth-2, PEG-4 dilaurate, sucrose fatty acid ester, sodium di(laurylamide glutamine) lysine, and oleth-8.

[0013] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the thickener includes at least one of cellulose and its derivatives, VP / eicosene copolymer, kaolin, hectorite, gum arabic, dextrin, gelatin, gellan gum, and guar gum.

[0014] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preservative includes at least one of phenoxyethanol and benzoate.

[0015] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the chelating agent includes at least one of citric acid and its salts, EDTA and its salts, and tartrate.

[0016] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the weight ratio of Centella asiatica extract to Cryptomeria japonica leaf extract is 1:0.8-1.5.

[0017] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the weight ratio of the Artemisia annua extract to the Verbena officinalis leaf extract is 0.5-1:1.

[0018] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preparation method of the Centella asiatica extract includes: drying and crushing Centella asiatica leaves, adding water and neutral protease for enzymatic hydrolysis, inactivating the enzyme, adding ethanol to adjust the ethanol weight concentration to 25-40wt%, heating and stirring for extraction, centrifuging, and drying the clear liquid to obtain the Centella asiatica extract.

[0019] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preparation method of the Cryptomeria fortunei leaf extract includes: drying and crushing the Cryptomeria fortunei leaves, adding a methanol solution with a concentration of 20-35wt%, heating and stirring for extraction, centrifuging, and drying the clear liquid to obtain the Cryptomeria fortunei leaf extract.

[0020] Preferably, the preparation methods of the Artemisia annua leaf extract and the Verbena leaf extract in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract are substantially the same, which may include drying and crushing the Artemisia annua leaf / Verbena leaf, then adding water, heating and stirring to extract, then cooling, adding ethanol to adjust the weight concentration to 25-45%, heating and stirring to extract, filtering, and drying to obtain the extract.

[0021] The present invention also provides a preparation method of the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, comprising: heating oil and moisturizer, stirring to obtain an oil phase; heating water, adding an emulsifier and stirring to obtain an aqueous phase; stirring and mixing the oil phase and the aqueous phase, then cooling, adding salicylic acid, a skin conditioner, a thickener, a preservative, and a chelating agent, stirring, standing for aging, and sterilizing to obtain the sensitive skin repair cream containing salicylic acid and Centella asiatica extract.

[0022] Preferably, the method for preparing the sensitive skin repair cream containing salicylic acid and Centella asiatica extract further comprises the steps of filling and packaging after sterilization.

[0023] The beneficial progress of the present invention is: The present invention prepares a cream formulation using water, oil, moisturizer, salicylic acid, a skin conditioner, an emulsifier, a thickener, a preservative, and a chelating agent; the skin conditioner comprises Centella asiatica extract, Cryptomeria japonica leaf extract, Artemisia annua extract, and Verbena officinalis leaf extract. The resulting repair cream exhibits excellent stability, highly effective skin repair, and good antioxidant and anti-aging effects.

[0024] The cream preparation of the present invention has no delamination and oil-water precipitation in the heat resistance, cold resistance and room temperature stability tests, indicating that the cream preparation prepared by the present invention has excellent stability, good heat resistance and cold resistance, and no delamination and oil-water precipitation when placed at room temperature.

[0025] The cream preparation of the present invention has good antioxidant effect and can effectively scavenge DPPH free radicals.

[0026] The present invention utilizes Centella asiatica and Cryptomeria japonica leaf extracts to significantly enhance the antioxidant activity of a cream preparation, and their combination imparts excellent anti-aging effects to the cream preparation. In the preparation of the Centella asiatica extract, the present invention employs a neutral protease for enzymatic hydrolysis in addition to extraction with an ethanol solution, significantly enhancing the free radical scavenging effect of the Centella asiatica extract. Furthermore, in the preparation of the Cryptomeria japonica leaf extract, the use of a 20-35 wt% methanol solution for extraction yields better results than other solutions, imparting a superior antioxidant effect to the cream preparation.

[0027] When the present invention uses Centella asiatica extract and Cryptomeria japonica leaf extract to prepare a cream preparation, the selection of the ratio of the two has a certain influence on the antioxidant effect of the cream preparation. The two are combined in an appropriate ratio (mass ratio of 1:0.8-1.5) to optimize the concentration of the active ingredients and make the antioxidant efficiency higher, thereby giving the cream a better anti-aging effect.

[0028] The Artemisia annua extract and the Verbena officinalis leaf extract prepared by the present invention have comparable antioxidant effects, and a combination of the two has little effect on the antioxidant effect of the cream preparation.

[0029] The cream preparation of the present invention has good fibroblast proliferation ability and can effectively repair the skin.

[0030] The present invention uses Centella asiatica and Cryptomeria japonica leaf extracts to enhance the proliferation of fibroblasts to a certain extent and improve the skin repair effect.

[0031] In the cream product of the present invention, the Artemisia annua extract and the Verbena leaf extract obtained by a specific process produce a synergistic effect to enhance the skin repair effect. Furthermore, the Artemisia annua extract and the Verbena leaf extract are selected in a mass ratio of 0.5-1:1 to further enhance the skin repair effect. DETAILED DESCRIPTION

[0032] The present invention adopts specific implementation methods to further illustrate the technical solutions and effects of the present invention.

[0033] The invention provides a sensitive skin repair cream containing salicylic acid and Centella asiatica extract. The raw materials are: water, oil, moisturizer, salicylic acid, skin conditioner, emulsifier, thickener, preservative and chelating agent.

[0034] Preferably, the skin conditioning agent includes Centella asiatica extract, Cryptomeria japonica leaf extract, Artemisia annua extract, and Verbena officinalis leaf extract.

[0035] Preferably, the sensitive skin repair cream containing salicylic acid and Centella asiatica extract comprises the following raw materials, in parts by weight: 50-100 parts of water, 2-5 parts of oil, 3-7 parts of moisturizer, 0.05-0.25 parts of salicylic acid, 1.2-3.2 parts of skin conditioner, 1-3 parts of emulsifier, 0.5-2 parts of thickener, 0-0.2 parts of preservative, and 0-0.5 parts of chelating agent.

[0036] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the skin conditioners include 0.3-0.8 parts of Centella asiatica extract, 0.3-0.8 parts of Cryptomeria japonica leaf extract, 0.3-0.8 parts of Artemisia annua extract and 0.3-0.8 parts of Verbena officinalis leaf extract.

[0037] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the oil includes at least one of castor oil fatty acid methyl ester, oleyl oleate, cetostearyl alcohol, polydimethylsiloxane, caprylic / capric glyceride, squalane, and isohexadecane.

[0038] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the moisturizer includes at least one of polyols, hyaluronic acid and derivatives thereof.

[0039] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the emulsifier includes at least one of Tween, ceteth-2, PEG-4 dilaurate, sucrose fatty acid ester, sodium di(laurylamide glutamine) lysine, and oleth-8.

[0040] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the thickener includes at least one of cellulose and its derivatives, VP / eicosene copolymer, kaolin, hectorite, gum arabic, dextrin, gelatin, gellan gum, and guar gum.

[0041] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preservative includes at least one of phenoxyethanol and benzoate.

[0042] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the chelating agent includes at least one of citric acid and its salts, EDTA and its salts, and tartrate.

[0043] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the weight ratio of Centella asiatica extract to Cryptomeria japonica leaf extract is 1:0.8-1.5.

[0044] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the weight ratio of the Artemisia annua extract to the Verbena officinalis leaf extract is 0.5-1:1.

[0045] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preparation method of the Centella asiatica extract includes: drying and crushing Centella asiatica leaves, adding water and neutral protease for enzymatic hydrolysis, inactivating the enzyme, adding ethanol to adjust the ethanol weight concentration to 25-40wt%, heating and stirring for extraction, centrifuging, and drying the clear liquid to obtain the Centella asiatica extract.

[0046] Preferably, in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, the preparation method of the Cryptomeria fortunei leaf extract includes: drying and crushing the Cryptomeria fortunei leaves, adding a methanol solution with a concentration of 20-35wt%, heating and stirring for extraction, centrifuging, and drying the clear liquid to obtain the Cryptomeria fortunei leaf extract.

[0047] Preferably, the preparation methods of the Artemisia annua leaf extract and the Verbena leaf extract in the sensitive skin repair cream containing salicylic acid and Centella asiatica extract are substantially the same, which may include drying and crushing the Artemisia annua leaf / Verbena leaf, then adding water, heating and stirring to extract, then cooling, adding ethanol to adjust the weight concentration to 25-45%, heating and stirring to extract, filtering, and drying to obtain the extract.

[0048] The present invention also provides a preparation method of the sensitive skin repair cream containing salicylic acid and Centella asiatica extract, comprising: heating oil and moisturizer, stirring to obtain an oil phase; heating water, adding an emulsifier and stirring to obtain an aqueous phase; stirring and mixing the oil phase and the aqueous phase, then cooling, adding salicylic acid, a skin conditioner, a thickener, a preservative, and a chelating agent, stirring, standing for aging, and sterilizing to obtain the sensitive skin repair cream containing salicylic acid and Centella asiatica extract.

[0049] Preferably, the method for preparing the sensitive skin repair cream containing salicylic acid and Centella asiatica extract further comprises the steps of filling and packaging after sterilization.

[0050] 1. Preparation Example Centella asiatica extract 1: The preparation method is as follows: dry and crush the leaves of Centella asiatica, add 8 times the mass of water and neutral protease (product number S10013, Source Leaf Biotechnology, added amount 200U / g material) to obtain the material, stir and enzymolyze at a temperature of 45°C and a speed of 60r / min for 2.5 hours, inactivate the enzyme, add ethanol to adjust the ethanol weight concentration to 30wt%, heat and stir and extract at a temperature of 55°C and a speed of 70r / min for 3 hours, centrifuge, and vacuum dry the supernatant at 60°C to a water content of 1.04wt% to obtain the Centella asiatica extract.

[0051] Centella asiatica extract 2: The preparation method is as follows: dry and crush the Centella asiatica leaves, add 8 times the mass of water of the crushed powder, stir at 45°C and 60 r / min for 2.5 hours, add ethanol to adjust the ethanol weight concentration to 30wt%, heat and stir at 55°C and 70 r / min for 3 hours, centrifuge, and vacuum dry the clear liquid at 60°C to a water content of 1.04wt%, to obtain the Centella asiatica extract.

[0052] Cryptomeria fortunei leaf extract 1: The preparation method is as follows: the Cryptomeria fortunei leaves are dried and crushed, a 27.5wt% methanol aqueous solution with a concentration 10 times the weight of the powder is added, and the mixture is heated and stirred at a temperature of 35°C and a speed of 65r / min for 4.5 hours. The mixture is centrifuged, and the clear liquid is vacuum dried at 60°C to a water content of 1.25wt% to obtain the Cryptomeria fortunei leaf extract.

[0053] Cryptomeria japonica leaf extract 2: The preparation method is as follows: the Cryptomeria japonica leaves are dried and crushed, a 27.5wt% ethanol aqueous solution with a concentration 10 times the weight of the powder is added, and the mixture is heated and stirred at a temperature of 35°C and a speed of 65r / min for 4.5 hours. The mixture is centrifuged and the clear liquid is vacuum dried at 60°C to a water content of 1.25wt% to obtain the Cryptomeria japonica leaf extract.

[0054] Artemisia annua extract: The preparation method is as follows: dry and crush the Artemisia annua, then add 20 times the weight of water of the powder and stir at 60°C and 70rpm for 4 hours, cool to 40°C, add ethanol to adjust the weight concentration to 30%, heat and stir at 45°C and 70rpm for 3.5 hours, then filter, and vacuum dry the filtrate at 60°C to a water content of 2.37wt% to obtain the Artemisia annua extract.

[0055] Verbena leaf extract: The preparation method is as follows: the verbena leaves are dried and crushed, and then 22 times the weight of the powder is added with water and stirred at 65°C and 70 rpm for 4.5 hours, cooled to 40°C, and ethanol is added to adjust the weight concentration to 35%. The extract is heated and stirred at 45°C and 70 rpm for 3.5 hours, and then filtered. The filtrate is vacuum dried at 60°C to a water content of 2.29 wt% to obtain an Artemisia annua extract.

[0056] The raw material composition and dosage of each cream are shown in Table 1-2.

[0057] Table 1: Raw material composition and dosage Table 2: Raw material composition and dosage Cream 10: Based on Cream 1, use Centella asiatica Extract 2 to replace Centella asiatica Extract 1, and the rest remains unchanged.

[0058] Cream 11: Based on Cream 1, use Cryptomeria japonica leaf extract 2 to replace Cryptomeria japonica leaf extract 1, and the rest remains unchanged.

[0059] The preparation methods of the above cream preparations are all: Heat oils (polydimethylsiloxane, squalane and isohexadecane) and moisturizers (glycerin, 1,3-butylene glycol, polyethylene glycol 400) to 75°C and stir at 60 rpm for 20 minutes to obtain an oil phase; heat water to 50°C, add emulsifiers (Tween-60, sodium di(laurylamide glutamine) lysine, PEG-4 dilaurate) and stir at 80 rpm for 10 minutes to obtain an aqueous phase; stir and mix the oil phase and the aqueous phase at 60 rpm for 10 minutes, then cool to 35°C, add salicylic acid, skin conditioner (selectively added in combination with the specific matters of such raw materials in each cream), thickener (gellan gum, hydroxypropyl cellulose), preservative phenoxyethanol, chelating agent EDTA-2Na, continue stirring at 80 rpm for 25 minutes, let stand at room temperature for aging for 2 hours, sterilize, and obtain a cream.

[0060] 2. Testing 1. Stability The heat resistance, cold resistance and room temperature stability of the above cream preparations were tested.

[0061] Heat stability: Place 100 mL of the solution in a sealed transparent glass bottle at 45°C for 30 days and observe the delamination and oil-water separation.

[0062] Cold resistance and stability: Place 100 mL of the solution in a sealed transparent glass bottle at -10°C for 30 days and observe the delamination and oil-water separation.

[0063] Room temperature stability: Place 100 mL of the solution in a sealed transparent glass bottle at room temperature for 60 days and observe the delamination and oil-water separation.

[0064] Among them, the grade of no stratification and no oil-water separation is A; the grade of a small amount of stratification or oil-water separation is B; the grade of a large amount of stratification or oil-water separation is B The test results are shown in Table 3.

[0065] Table 3: Stability test The stability of the cream preparations 1-11 was tested using the above-mentioned test method. The test results showed that in the heat resistance, cold resistance and room temperature stability tests, the cream preparations 1-11 showed no delamination and no oil-water precipitation (grade A), indicating that the cream preparations prepared by the present invention have excellent stability, good heat resistance and cold resistance, and no delamination and oil-water precipitation when placed at room temperature.

[0066] 2. Antioxidant test Prepare test samples: Cream preparation group: The above cream preparation was mixed with deionized water at a ratio of 1:15 (mass ratio) to obtain a diluent. 100 μL of the diluent was added with 100 μL of a 0.1 mM DPPH solution, the mixture was mixed, and the mixture was stored in the dark at room temperature for 20 minutes to react to obtain a preparation group solution.

[0067] Blank group: 100 μL of deionized water and 100 μL of 0.1 mM DPPH solution were mixed and stored in the dark at room temperature for 20 minutes to react to obtain a blank group solution.

[0068] The absorbance (A) values ​​of the cream preparation and blank solutions at 520 nm were measured using a microplate reader. The DPPH radical scavenging rate was then calculated using the following formula: DPPH radical scavenging rate / % = 100% × (A0 - A1) / A0, where A0 is the absorbance of the blank solution and A1 is the absorbance of the preparation solution. Five parallel tests were performed, and the average value was taken. The antioxidant test results are shown in Table 3.

[0069] Table 4: Antioxidant test results Combined with the test results in Table 4, it can be seen that the cream preparation of the present invention has a good antioxidant effect and can effectively scavenge DPPH free radicals.

[0070] Comparison of Creams 1 and 3 shows that the present invention's use of Centella asiatica and Cryptomeria japonica leaf extracts can significantly enhance the antioxidant activity of the cream preparation, and their combination imparts excellent anti-aging effects to the cream preparation. Furthermore, comparison of Creams 1, 10-11 shows that, in the preparation of the Centella asiatica extract, the use of a neutral protease for enzymatic hydrolysis in addition to the ethanol solution extraction significantly enhances the free radical scavenging effect of the Centella asiatica extract. Furthermore, in the preparation of the Cryptomeria japonica leaf extract, the use of a 20-35 wt% methanol solution is more effective than the ethanol solution, imparting a superior antioxidant effect to the cream preparation.

[0071] From the comparison of Creams 1, 4-5, it can be seen that when the Centella asiatica extract and Cryptomeria japonica leaf extract are used to prepare the cream preparation, the selection of the ratio of the two has a certain influence on the antioxidant effect of the cream preparation. The two are combined in an appropriate ratio (mass ratio 1:0.8-1.5) to optimize the concentration of the active ingredients and make the antioxidant efficiency higher, thereby giving the cream a better anti-aging effect.

[0072] Combined with the tests on creams 1, 6-9, it can be seen that the antioxidant effects of Artemisia annua extract and Verbena officinalis leaf extract are comparable, and the combination of the two has little effect on the antioxidant effect of the cream preparation.

[0073] 3. Repair effect test Test the effect of the cream on fibroblast proliferation and verify the effect of the cream preparation on skin repair.

[0074] Fibroblast L929 cells were cultured in DMEM medium containing 10% fetal bovine serum (product number OMDCM-004, Omas (Shanghai) Biotechnology Co., Ltd.) at 37°C and 5% CO2 until the cells reached the logarithmic growth phase. The cells were then digested with 0.25wt% trypsin, collected, and the cell concentration was adjusted to 5×10 4 Cells were cultured in a 37°C, 5% CO2 incubator for 48 hours. After culture, 100 μL of the cultured cells were seeded into each well of a 96-well plate. An equal volume of the test solution (prepared by mixing the above-mentioned cream with deionized water at a weight ratio of 1:120) was added to the experimental group, while an equal volume of DMEM medium was added to the blank group. The cells were then cultured for a further 72 hours at 37°C, 5% CO2. After completion of the incubation period, 15 μL of 0.5 mg / L MTT solution was added to each well and incubated for 4 hours. The supernatant was removed from each well, and 200 μL of DMSO was added to each well. The cells were shaken in a 37°C waterbath for 15 minutes. The absorbance (OD) at 570 nm was measured using a microplate reader, and the relative cell proliferation rate was calculated. The relative proliferation rate was calculated as follows: Relative proliferation rate / % = (OD value of the experimental group / OD value of the blank group - 1) × 100%. Five replicates were performed, and the average value was calculated. The repair efficacy test results are shown in Table 5.

[0075] Table 5: Repair effect test results Combined with the test results in Tables 3-4, it can be seen that the cream preparation of the present invention has a good ability to proliferate fibroblasts and can effectively repair the skin.

[0076] From the comparison between Cream 1 and Cream 3, it can be seen that the Centella asiatica and Cryptomeria japonica leaf extracts used in the present invention can enhance the proliferation of fibroblasts to a certain extent and improve the skin repair effect.

[0077] Comparison of Creams 1, 6-7 shows that the proliferation effect of the verbena leaf extract or Artemisia annua extract in Creams 6-7, when the amount of Artemisia annua extract and Artemisia annua leaf extract in the cream preparations is kept consistent with the total amount of Artemisia annua extract and Artemisia annua leaf extract in the cream preparations, is lower than that of Cream 1. This shows that in the cream products of the present invention, the extracts obtained by the specific processes of the two produce a synergistic effect to enhance the skin repair effect. Combining the tests of Creams 1, 8-9, it can be seen that when the ratio of Artemisia annua extract to Verbena leaf extract is changed outside the range of 0.5-1:1, the skin repair effect of the cream is relatively poor. That is, the present invention selects an Artemisia annua extract to Verbena leaf extract mass ratio of 0.5-1:1 to further enhance the skin repair effect.

Claims

1. A sensitive skin repair cream containing salicylic acid and Centella asiatica extract, characterized in that: The ingredients are: water, oil, moisturizer, salicylic acid, skin conditioner, emulsifier, thickener, preservative, chelating agent; Among them, the skin conditioning agents include Centella asiatica extract, Cryptomeria japonica leaf extract, Artemisia annua extract and Verbena officinalis leaf extract.

2. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: In terms of weight, the raw materials are: 50-100 parts of water, 2-5 parts of oil, 3-7 parts of moisturizer, 0.05-0.25 parts of salicylic acid, 1.2-3.2 parts of skin conditioner, 1-3 parts of emulsifier, 0.5-2 parts of thickener, 0-0.2 parts of preservative, and 0-0.5 parts of chelating agent.

3. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The skin conditioning agent includes 0.3-0.8 parts of Centella asiatica extract, 0.3-0.8 parts of Cryptomeria japonica leaf extract, 0.3-0.8 parts of Artemisia annua extract, and 0.3-0.8 parts of Verbena officinalis leaf extract.

4. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The oil comprises at least one of castor oil fatty acid methyl ester, oleyl oleate, cetostearyl alcohol, polydimethylsiloxane, caprylic / capric glyceride, squalane and isohexadecane.

5. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The moisturizing agent includes at least one of polyol, hyaluronic acid and derivatives thereof.

6. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The emulsifier includes at least one of Tween, ceteth-2, PEG-4 dilaurate, sucrose fatty acid ester, sodium di(laurylamide glutamine) lysine, and oleth-8.

7. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The thickener comprises at least one of cellulose and its derivatives, VP / eicosene copolymer, kaolin, hectorite, gum arabic, dextrin, gelatin, gellan gum, and guar gum; Or, the preservative includes at least one of phenoxyethanol and benzoate; Alternatively, the chelating agent includes at least one of citric acid and its salts, EDTA and its salts, and tartrate.

8. The sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 1, characterized in that: The weight ratio of the Centella asiatica extract to the Cryptomeria japonica leaf extract is 1:0.8-1.5; or the weight ratio of the Artemisia annua extract to the Verbena officinalis leaf extract is 0.5-1:

1.

9. A method for preparing a sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to any one of claims 1 to 8, characterized in that: The preparation method is as follows: heating oil and moisturizer, stirring to obtain an oil phase; heating water, adding an emulsifier and stirring to obtain an aqueous phase; stirring and mixing the oil phase and the aqueous phase, then cooling, adding salicylic acid, a skin conditioner, a thickener, a preservative, and a chelating agent, stirring, standing for aging, and sterilizing to obtain a sensitive skin repair cream containing salicylic acid and Centella asiatica extract.

10. The method for preparing a sensitive skin repair cream containing salicylic acid and Centella asiatica extract according to claim 9, characterized in that: It also includes the processes of filling and packaging after sterilization.

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