Active soothing lotion and preparation method thereof

Abstract

The invention discloses a vitality soothing lotion and a preparation method thereof, and belongs to the technical field of external pharmaceutical preparations. The soothing lotion is composed of extracts of Chinese herbal medicines such as dracocephalum dracocephalum, leaves of white pearls, safflower carthamus, angelica sinensis and the like, menthol and borneol, achieves the effects of relieving pain, easing pain, dredging collaterals, promoting blood circulation to remove blood stasis and mildly heating through a multi-target synergistic effect, and is suitable for people suffering from shoulder and neck pain, waist and leg pain and joint pain. The preparation method comprises the steps of raw material pretreatment, water decoction and extraction, ethanol extraction, component fusion, pH adjustment, sterilization and packaging and the like. The product is natural, safe, high in permeability and lasting in effect, and an effective relieving scheme is provided for people suffering from musculoskeletal pain.

Description

Technical Field

[0001] The present invention belongs to the technical field of external-use pharmaceutical preparations, and specifically relates to a vitality soothing liquid with Chinese herbal medicine extracts as the core ingredient and a preparation method thereof, which is suitable for relieving pain, numbness, fatigue and soreness in the shoulders, neck, waist, legs, joints and other parts. Background Art

[0002] Existing topical analgesic products have the following deficiencies: 1. Single efficacy: Most products contain only a single ingredient such as menthol or borneol, which can only temporarily relieve superficial symptoms; 2. Poor permeability: Traditional plasters and patches are prone to leaving residue on the skin, and the active ingredients are difficult to penetrate deeply; 3. Irritation: Some products contain ingredients such as methyl salicylate, which may cause allergies or burns if used for a long time; 4. Short-lived effect: Warm-sensing products (such as heating patches) last for a short time (usually less than 2 hours) and need to be replaced frequently.

[0003] In order to solve the above problems, the present invention provides a multi-component synergistic, deep-penetrating, long-lasting soothing vitality soothing solution. Summary of the Invention

[0004] The purpose of the present invention is to provide a vitality soothing liquid and a preparation method thereof, which achieves multiple functions of soothing and relieving pain, dredging collaterals, promoting blood circulation and removing blood stasis, and mild fever through the synergistic effect of Chinese herbal medicines such as Qilinjie and Pleurotus ostreatus leaves, and is suitable for people with shoulder, neck, waist, leg, and joint pain.

[0005] Ingredients The vitality soothing solution of the present invention is composed of the following raw materials in parts by weight: Kirinja Extract: 15-25 servings Efficacy: Promote blood circulation and relieve pain, remove blood stasis and stop bleeding, promote local blood circulation, and accelerate the excretion of metabolic waste.

[0006] Gaultheria sinensis Leaf Extract: 12-20 servings Efficacy: dispel wind and dampness, relax muscles and tendons, relieve muscle spasms and joint stiffness.

[0007] Safflower Extract: 10-18 servings Efficacy: Promote blood circulation and menstruation, disperse blood stasis and relieve pain, improve microcirculation disorders.

[0008] Angelica Extract: 8-15 servings Efficacy: Nourishes blood and promotes blood circulation, regulates menstruation and relieves pain, and enhances tissue repair ability.

[0009] Panax notoginseng root extract: 6-12 servings Efficacy: Disperse blood stasis and stop bleeding, reduce swelling and relieve pain, inhibit the release of inflammatory factors.

[0010] Turmeric Extract: 5-10 servings Efficacy: Promotes menstruation and relieves pain, promotes blood circulation and qi, and relieves rheumatic joint pain.

[0011] Chuanxiong Extract: 5-10 servings Efficacy: Promotes qi circulation, relieves depression, dispels wind and dampness, and enhances the permeability of other ingredients.

[0012] Wintergreen Extract: 4-8 servings Efficacy: Clears away heat and detoxifies, dispels wind and dampness, and helps relieve muscle soreness.

[0013] Menthol: 3-6 servings Efficacy: Cooling and relieving itching, soothing skin irritation, and promoting transdermal absorption.

[0014] Borneol: 2-5 servings Efficacy: Refreshing the mind, clearing away heat and relieving pain, and enhancing the targeting effects of other ingredients.

[0015] Preparation method 1. Raw material pretreatment: Dry and grind the kelp, Gaultheria paniculata leaves, safflower, angelica root, notoginseng root, turmeric, ligusticum chuanxiong, and holly, and pass through a 60-mesh sieve for later use; Menthol and borneol are extracted using supercritical CO2 extraction to ensure that the retention rate of volatile components is ≥90%.

[0016] 2. Extraction and concentration: Water decoction extraction: add the pretreated plant powder (such as Qilinjie) to purified water at a material-liquid ratio of 1:8, decoct at 80℃ for 2 hours, and filter to obtain the first extract; repeat the decoction of the residue at a material-liquid ratio of 1:6 for 1 hour, combine the two extracts, and concentrate to a relative density of 1.10-1.15 (60℃).

[0017] Ethanol extraction: Add an equal volume of 75% ethanol to the concentrated water extract, let it stand for 24 hours, filter to remove the precipitate, and recover the ethanol until there is no alcohol taste to obtain a concentrated solution with a total polysaccharide content ≥30%.

[0018] 3. Ingredient fusion: Preparation of base liquid: Mix the concentrate with menthol and borneol extracts, place in a homogenizer, and high-speed shear at 8000 r / min for 10 minutes to form a uniform emulsion.

[0019] pH adjustment: Use 10% citric acid solution to adjust the pH to 5.0-6.0 to enhance the stability of the ingredients.

[0020] Final conditioning and sterilization: Add 0.1% methylparaben as a preservative, sterilize with high-pressure steam at 121°C for 15 minutes, and cool to room temperature.

[0021] 4. Packaging and storage: The sterilized soothing solution is divided into brown glass bottles (specification 30ml / bottle), sealed and stored away from light. The shelf life is 24 months. Beneficial effects

[0022] The vitality soothing solution of the present invention has the following significant advantages: 1. Multi-target synergistic effect: Analgesic pathway: Qilinjie and Panax notoginseng root inhibit prostaglandin synthesis and relieve pain signal transmission; Anti-inflammatory pathway: Turmeric and Chuanxiong inhibit the NF-κB pathway and reduce the release of inflammatory factors (such as TNF-α and IL-6); Penetration-enhancing pathway: Menthol and borneol open the gaps in the skin's stratum corneum, increasing the transdermal absorption rate of other ingredients (3-5 times higher than traditional products).

[0023] 2. Long-lasting mild fever: When the methyl salicylate analogues in the leaves of Gaultheria sinensis and Ilex holly are spread evenly and come into contact with the skin, they slowly release heat (lasting for 4-6 hours) and the temperature is controlled at 38-42°C to avoid low-temperature burns.

[0024] 3. Safe and non-irritating: Natural ingredients account for more than 95%, no hormones, no heavy metal residues; Human patch tests have shown that the incidence of redness and swelling in people with sensitive skin is less than 0.5%.

[0025] 4. Easy to use: Liquid dosage forms are easy to apply and do not stain clothing; The effect can be further enhanced by combining it with massage techniques (such as kneading and pushing). DETAILED DESCRIPTION

[0026] The present invention is described in detail below through specific examples. Example

[0027] 1. Weigh the raw materials (parts by weight): 20 parts of Kirinja extract, 15 parts of Gaultheria scabra leaves extract, 12 parts of Carthamus tinctorius extract, 10 parts of Angelica sinensis extract, 8 parts of Panax notoginseng root extract, 6 parts of Curcuma longa extract, 5 parts of Chuanxiong extract, 4 parts of Wintergreen extract, 4 parts of menthol, and 3 parts of borneol.

[0028] 2. Preparation process: Pretreatment: The plant raw materials were dried, crushed and sieved; menthol and borneol were extracted using supercritical CO2 (pressure 20 MPa, temperature 40°C).

[0029] Extraction: decoct twice in water, combine the extracts and concentrate to a relative density of 1.12.

[0030] Fusion: Mix the concentrate with menthol and borneol extracts, process in a homogenizer for 10 minutes, and adjust the pH to 5.5.

[0031] Sterilized packaging: Sterilize after adding preservatives and pack into brown bottles. Example

[0032] 1. Weigh the raw materials (parts by weight): 22 parts of Kirinja extract, 18 parts of Gaultheria scabra leaves extract, 14 parts of Carthamus tinctorius extract, 9 parts of Angelica sinensis extract, 7 parts of Panax notoginseng root extract, 5 parts of Curcuma longa extract, 4 parts of Chuanxiong extract, 3 parts of Wintergreen extract, 3 parts of menthol, and 2 parts of borneol.

[0033] 2. Preparation process: Pretreatment: The plant material was crushed and passed through an 80-mesh sieve; the extraction pressure of menthol and borneol was adjusted to 25 MPa.

[0034] The extraction: water decoction material-liquid ratio was adjusted to 1:10, and the first decoction time was extended to 2.5 h.

[0035] Fusion: Increase the homogenizer speed to 10,000 r / min, process for 15 minutes, and adjust the pH to 5.8.

[0036] Sterilization packaging: The sterilization temperature is reduced to 115°C and the time is extended to 20 minutes.

Claims

1. A soothing and energizing liquid, characterized in that: The invention is composed of the following raw materials in parts by weight: 15-25 parts of kelp extract, 12-20 parts of gaultheria scabra leaf extract, 10-18 parts of safflower extract, 8-15 parts of angelica extract, 6-12 parts of notoginseng root extract, 5-10 parts of turmeric extract, 5-10 parts of ligusticum chuanxiong extract, 4-8 parts of holly extract, 3-6 parts of menthol and 2-5 parts of borneol.

2. The soothing and revitalizing liquid according to claim 1, characterized in that: The content of dracotoxin in the Kirinja extract is ≥1.5%; the content of methyl salicylate analogues in the Gaultheria serrata leaf extract is ≥2.0%.

3. A method for preparing the vitality soothing solution according to claim 1 or 2, characterized in that: The following steps are involved: Raw material pretreatment: Dry and crush the plant materials such as kelp, then pass through a 60-80 mesh sieve; extract menthol and borneol using supercritical CO2 extraction method; Water decoction extraction: add purified water at a solid-liquid ratio of 1:8-1:10, decoct at 80°C for 2-2.5 hours, filter and repeat the decoction once, combine the extracts and concentrate to a relative density of 1.10-1.15; Ethanol extraction: add an equal volume of 75% ethanol to the concentrate, let it stand, filter and recover the ethanol; Ingredient fusion: Mix the processed extract with menthol and borneol extracts, and homogenize and shear at high speed; pH adjustment and sterilization: adjust the pH to 5.0-6.0 with citric acid solution, add preservatives and sterilize with high pressure steam; Packaging and storage: Divide into brown glass bottles and store in sealed containers away from light.

4. The production method according to claim 3, characterized in that: The high-speed homogenization shearing speed is 8000-10000 r / min, and the time is 10-15 minutes; the high-pressure steam sterilization conditions are 115-121° C. and 15-20 minutes.