Animal fixing device and animal test equipment

Abstract

The invention provides an animal fixing device and animal test equipment. A first connecting assembly of the animal fixing device is connected to a supporting base; the second connecting assembly is connected to the supporting base. The running disc is arranged at the end, away from the supporting base, of the first connecting assembly and can rotate relative to the first connecting assembly. A groove part is formed in the side, deviating from the first connecting assembly, of the running disc, at least part of the inner wall face of the groove part is a curved surface, and the groove part is used for running of a test animal; the fixing piece is arranged at one end of the second connecting assembly away from the supporting base; the end, away from the supporting base, of the second connecting assembly is used for stretching into the area where the groove part is located so as to fix the head of a test animal on the running disc. According to the animal fixing device, the bent curved surface is arranged at the groove part of the running disc, so that stable support can be provided for the test animal when the test animal is in different body positions, stress generated when the test animal moves is counteracted, and the stability of the animal fixing device is improved.

Description

Technical Field

[0001] The present application belongs to the field of brain science research technology, and in particular relates to an animal fixation device and animal testing equipment. Background Art

[0002] In brain science research, animal fixation devices are used to fix awake, freely moving mice, keeping their heads stable during imaging while allowing appropriate body movement, so that information on brain structure and function can be obtained through techniques such as two-photon microscopy. They are an important tool for conducting in vivo research.

[0003] In related technologies, animal fixation devices are difficult to fully eliminate the stress generated when mice move, and the slight displacement of the brain caused by body movement will affect the imaging quality. Summary of the Invention

[0004] The purpose of the present application is to provide an animal fixation device and an animal testing device, aiming to solve the problem of low stability of animal fixation devices in traditional technologies.

[0005] A first aspect of an embodiment of the present application provides an animal fixing device for fixing a test animal, the animal fixing device comprising:

[0006] Support base;

[0007] a first connecting assembly connected to the supporting base;

[0008] a second connecting assembly connected to the support base;

[0009] a running disc, the running disc being arranged at an end of the first connecting assembly away from the support base and being rotatable relative to the first connecting assembly; a groove being provided on a side of the running disc facing away from the first connecting assembly, at least a portion of an inner wall surface of the groove being a curved surface, the groove being used for allowing the test animal to run;

[0010] A fixing member is provided at one end of the second connecting component away from the support base; wherein, the end of the second connecting component away from the support base is used to extend into the area where the groove portion is located to fix the head of the test animal on the running disc.

[0011] In some embodiments of the present application, at least a portion of the inner wall surface of the groove portion is at least one of a spherical crown surface, an ellipsoidal crown surface, and a rotational paraboloid.

[0012] In some embodiments of the present application, all inner wall surfaces of the groove portion are curved surfaces.

[0013] In some embodiments of the present application, a plurality of raised lines are provided on the inner wall surface of the groove portion, and the plurality of raised lines are arranged at intervals along the annular direction of the groove portion.

[0014] In some embodiments of the present application, the support base includes a first bottom plate member, a first universal ball joint and a first universal ball, the first universal ball joint is arranged on the first bottom plate member, a first groove is provided on the first universal ball joint, the first universal ball is partially accommodated in the first groove and is slidably connected to the groove wall of the first groove; a first connecting rod is provided on the part of the first universal ball outside the first groove, and the first connecting rod is connected to the first connecting component and the second connecting component.

[0015] In some embodiments of the present application, the first connecting assembly includes a first connecting member, a shock absorbing member, and a second bottom plate member, the first connecting member is connected to the first connecting rod, the shock absorbing member is provided at an end of the first connecting member away from the first connecting rod, and the second bottom plate member is provided on a side of the shock absorbing member away from the first connecting member;

[0016] Wherein, the running disc is arranged on the bottom plate, and a rotary bearing is provided between the running disc and the bottom plate, so that the running disc can rotate relative to the bottom plate.

[0017] In some embodiments of the present application, the shock-absorbing member includes a shock-absorbing spring and a telescopic rod, and the telescopic rod is telescopically connected between the first connecting member and the second bottom plate member; the shock-absorbing spring is arranged outside the telescopic rod, and the shock-absorbing spring is connected to the first connecting member and the second bottom plate member.

[0018] In some embodiments of the present application, the number of the shock absorbing springs is at least four, and the at least four shock absorbing springs are distributed in a rectangular pattern.

[0019] In some embodiments of the present application, the first connecting member includes a first fixing portion, a connecting portion, and a second fixing portion connected in sequence, the first fixing portion is connected to the first connecting rod, and the shock absorber is arranged on the second fixing portion; one end of the connecting portion is connected to the first fixing portion, the other end of the connecting portion extends along a side close to the support base, and the other end of the connecting portion is connected to the second fixing portion, so that the first fixing portion and the second fixing portion are parallel to each other and are not in the same plane.

[0020] In some embodiments of the present application, the second connecting assembly includes a second connecting member and a connecting rod, the second connecting member is connected to the first connecting rod, a second universal ball table is provided on an end of the second connecting member away from the first connecting rod, a second universal ball is fixed to the second universal ball table, a second groove is provided at one end of the connecting rod, and the second universal ball is partially accommodated in the second groove;

[0021] A third universal ball joint is provided on the end of the connecting support rod away from the second universal ball joint, a third groove is provided on the third universal ball joint, a part of a third universal ball is provided in the third groove, a second connecting rod is provided on the part of the third universal ball exposed outside the third groove, and the second connecting rod is connected to the fixing member.

[0022] In some embodiments of the present application, the connecting support rod includes a first support rod and a second support rod rotatably connected to each other, the first support rod is provided with the second universal ball table, and the second support rod is provided with a third universal ball table.

[0023] In some embodiments of the present application, the fixing member includes a fixing bracket and a fixing ring, the fixing ring is fixed on the fixing bracket, the fixing bracket is detachably connected to the connecting rod, and the fixing ring is used to fix the head of the test animal.

[0024] In some embodiments of the present application, the fixing ring has a first side portion for contacting the test animal, and the first side portion is arranged as a curved structure along the annular direction of the fixing ring, and the curved structure is used to adapt to the upper part of the skull of the test animal.

[0025] In some embodiments of the present application, the fixing ring satisfies at least one of the following conditions:

[0026] The first side portion is provided with a connecting groove portion, the connecting groove portion is communicated with the inner ring space of the fixing ring, and the connecting groove portion is used for perfusing and bonding the fixing colloid of the test animal;

[0027] A convex portion is provided on the outer ring wall of the fixing ring, and a fixing hole is provided in the convex portion. The fixing hole passes through the convex portion along the axial direction of the fixing ring, and the fixing hole is used for perfusing and bonding the fixing colloid of the test animal.

[0028] In some embodiments of the present application, the animal securing device satisfies at least one of the following conditions:

[0029] The animal fixing device includes a first knob screw, the first knob screw is used to pass through the first universal ball table to the first groove, and is used to abut against the first universal ball;

[0030] The animal fixing device includes a second knob screw, the second knob screw is used to pass through the first support rod to the second groove, and is used to abut against the second universal ball;

[0031] The animal fixing device includes a third knob screw, and the third knob screw is used to pass through the second support rod to the first support rod to adjust the relative angle between the first support rod and the second support rod;

[0032] The animal fixing device includes a fourth knob screw, which is used to pass through the second support rod to the third groove and abut against the third universal ball.

[0033] The second aspect of the present application also provides an animal testing device, including a testing instrument, a testing table and the animal fixing device as described above, wherein the supporting base of the animal fixing device is detachably connected to the testing table, and the testing instrument is used to obtain test data of the test animal.

[0034] The beneficial effects of the embodiments of the present invention compared with the prior art are as follows: in the above-mentioned animal fixing device and animal testing equipment, the animal fixing device is used to fix the test animal, and the animal fixing device includes a support base, a first connecting component, a second connecting component, a running disc and a fixing member; the first connecting component is connected to the support base; the second connecting component is connected to the support base; the running disc is arranged at an end of the first connecting component away from the support base, and the running disc can rotate relative to the first connecting component; a groove portion is provided on the side of the running disc away from the first connecting component, and at least part of the inner wall surface of the groove portion is curved curved surface, the groove portion is used for the test animal to run; a fixing piece is provided at one end of the second connecting component away from the support base; wherein, the end of the second connecting component away from the support base is used to extend into the area where the groove portion is located to fix the head of the test animal on the running disc; in the present application, a fixing piece is used to fix the head of the test animal, which is conducive to fixing the test animal in the running disc; and by providing a curved surface in the groove portion of the running disc, it is conducive to ensuring that stable support can be provided for the test animal when the test animal is in different body positions, so as to offset the stress generated when the test animal moves, thereby helping to improve the stability of the animal fixing device. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 A schematic structural diagram of an animal securing device provided in one embodiment of the present application;

[0036] Figure 2 Another structural schematic diagram of an animal securing device provided in one embodiment of the present application;

[0037] Figure 3A schematic structural diagram of an animal securing device provided in another embodiment of the present application;

[0038] Figure 4 Provided for an embodiment of this application Figure 1 Schematic diagram of the local A enlarged structure;

[0039] Figure 5 A schematic structural diagram of an animal securing device provided in yet another embodiment of the present application;

[0040] Figure 6 A schematic structural diagram of an animal securing device provided in yet another embodiment of the present application;

[0041] Figure 7 A schematic structural diagram of an animal securing device provided in yet another embodiment of the present application;

[0042] Figure 8 A schematic structural diagram of an animal securing device provided in yet another embodiment of the present application;

[0043] Figure 9 This is a schematic structural diagram of an animal fixing device provided in yet another embodiment of the present application.

[0044] Specific element symbol description: 100-support base, 110-first bottom plate, 111-screw hole, 120-first universal ball table, 130-first universal ball, 140-first connecting rod, 150-first knob screw, 200-first connecting assembly, 210-first connecting member, 211-first fixing part, 212-connecting part, 213-second fixing part, 220-shock absorber, 221-shock absorber spring, 222-telescopic rod, 230-second bottom plate, 300-second connecting assembly, 310-second connecting member, 320-connecting support rod, 3 21-first support rod, 322-second support rod, 323-second universal ball table, 324-third universal ball table, 325-second groove, 326-third groove, 327-second knob screw, 328-third knob screw, 329-fourth knob screw, 400-running plate, 410-groove portion, 411-raised line, 500-fixing part, 510-fixing bracket, 520-fixing ring, 521-connecting groove portion, 522-raised portion, 523-fixing hole, 600-rotating bearing, 700-running plate base, 710-toothed groove structure. DETAILED DESCRIPTION

[0045] In order to make the technical problems, technical solutions and beneficial effects to be solved by this application more clearly understood, this application is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0046] It should be noted that when an element is referred to as being “disposed on” another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being “connected to” another element, it may be directly connected to the other element or indirectly connected to the other element.

[0047] It should be understood that the terms "length", "width", "up", "down", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0048] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. Throughout the description of this application, "plurality" means two or more, unless otherwise specifically defined.

[0049] It is important to know that brain science research, as the forefront and focus of current global science, has the core goal of deeply revealing the complex activity mechanisms of the brain. To achieve this goal, scientists need to accurately observe and study brain activity under real physiological conditions. In this context, the use of animal models, especially mice with clear genetic backgrounds and easy experimental manipulation for in vivo research, has become an indispensable and important means in brain science research. Brain imaging technologies, such as two-photon microscopy, optical coherence tomography, ultrasound imaging, calcium imaging, etc., have become important tools for studying brain activity in living animals because they can provide rich structural and functional information on brain capillaries and nerves.

[0050] However, these imaging techniques have extremely high requirements for the structural stability of the imaging area. Even a slight movement in the imaging area may cause image drift, blur, artifacts, and even make effective data acquisition impossible. During the experiment, although anesthesia of mice can effectively suppress the deviation of the imaging area caused by their movement, anesthesia will interfere with the neural activity and blood circulation of the mouse brain, and deprive the mouse of the ability to exhibit natural behavior during the experiment. Therefore, using mice with fixed heads but awake to conduct experiments is still an important way to use brain imaging technology to study the neural activity of the mouse brain.

[0051] However, existing animal fixation technology has the problem of being unable to fully eliminate the stress generated by mouse movement. When mice move freely while awake, their body movements can cause tiny displacements in the brain, which can seriously affect imaging quality. Specifically, while existing animal fixation devices allow a certain degree of body movement while fixing the mouse's head, they often cannot effectively eliminate the stress generated during movement, especially when the mouse performs rapid or complex movements. This stress can cause offset and blurring of the imaging area.

[0052] Based on this, the present application improves the relevant animal fixation devices and animal testing equipment.

[0053] See also Figure 1 and Figure 2 , Figure 1 shows a schematic structural diagram of the animal fixing device provided in this embodiment, Figure 2 Another structural schematic diagram of the animal fixation device provided in the present embodiment is shown; the animal fixation device of the embodiment of the present application is used to fix test animals, and the animal fixation device includes a support base 100, a first connecting component 200, a second connecting component 300, a running disc 400 and a fixing component 500; the first connecting component 200 is connected to the support base 100; the second connecting component 300 is connected to the support base 100; the running disc 400 is arranged at an end of the first connecting component 200 away from the support base 100, and the running disc 400 can rotate relative to the first connecting component 200; a groove portion 410 is provided on a side of the running disc 400 away from the first connecting component 200, at least part of the inner wall surface of the groove portion 410 is a curved surface, and the groove portion 410 is used for the test animal to run; the fixing component 500 is arranged at an end of the second connecting component 300 away from the support base 100; wherein, the end of the second connecting component 300 away from the support base 100 is used to extend into the area where the groove portion 410 is located to fix the head of the test animal on the running disc 400.

[0054] It should be explained that an animal immobilization device is a device specifically designed to immobilize experimental animals (such as mice) to maintain the stability of the animal's head during experiments such as brain imaging, while allowing free movement of the body. The support base 100 serves as the foundation of the entire device, providing stable support. The first connecting assembly 200 and the second connecting assembly 300 are respectively connected to the support base 100 and are used to support and secure the running disc 400 and the fixing member 500. The running disc 400 is the platform for the experimental animal to run on and can rotate relative to the first connecting assembly 200 to accommodate the experimental animal's movement. The fixing member 500 is used to secure the experimental animal's head to ensure its stability during imaging.

[0055] It is understandable that when the test animal runs in the groove portion 410, the curved surface (such as a hemispherical shape) can fit its body posture, evenly disperse the pressure generated by the movement, and avoid local stress concentration being transmitted to the head; at the same time, the running disc 400 can rotate freely relative to the first connecting component 200, and can dynamically buffer the stress (such as friction and thrust) generated in the plane direction of the running disc 400 when the test animal moves, and eliminate the reaction force caused by the obstruction of movement. The animal fixing device of the embodiment of the present application effectively eliminates the influence of motion stress on imaging quality by fixing the head of the test animal and allowing its body to move freely on the running disc 400 with the curved surface groove portion 410, and significantly improves the clarity and accuracy of the imaging; at the same time, the stable head fixation and comfortable running environment reduce the stress response of the test animal, enhance the reliability and repeatability of the experiment, and provide more accurate data support for brain science research.

[0056] In some embodiments, the test animal is a mouse.

[0057] In some embodiments of this application, please continue to refer to Figure 1 and Figure 2 In the embodiment of the present application, at least a portion of the inner wall surface of the groove portion 410 is at least one of a spherical crown surface, an ellipsoidal crown surface, and a rotational paraboloid.

[0058] It needs to be explained that the spherical crown surface (such as Figure 1 and Figure 2 The curvature of a parabola (shown in Figure 1) is determined by the radius of the sphere. For example, a section through the center of the sphere forms a hemispherical crown. An ellipsoidal crown is a localized surface formed by the ellipsoidal surface being cut by a plane. This surface's curvature varies along different axes, determined by the major and minor radii, as well as the location of the cut. A parabola of revolution is a surface formed by the rotation of a parabola about its axis of symmetry. Its curvature varies uniformly from the vertex to the edge, with a relatively flat top region and gradually steeper edges.

[0059] It's understandable that improving the stability and comfort of experimental animals in different body positions can optimize the results of brain imaging experiments. The spherical, hemispherical, and paraboloidal designs can better conform to the body curves of experimental animals, reducing shaking and instability during running, thereby reducing the interference of motion stress on imaging quality and ensuring the accuracy and reliability of experimental data.

[0060] In some embodiments, at least a portion of the inner wall surface of the groove portion 410 may also be other hemispherical surfaces.

[0061] In some embodiments of the present application, all inner wall surfaces of the groove portion 410 are curved surfaces.

[0062] As can be understood, this fully curved inner wall design can more evenly support the body of the test animal, providing a stable and conforming support environment regardless of the animal's running or static position. This design not only further enhances the stability of the test animal on the running plate 400 and reduces imaging area shifts caused by changes in body position, but also improves the comfort of the test animal, helping it maintain a natural state during the experiment, thereby ensuring the high quality and reliability of brain imaging experiments.

[0063] In some embodiments of this application, please continue to refer to Figure 1 and Figure 2 A plurality of raised lines 411 are provided on the inner wall surface of the groove portion 410 , and the plurality of raised lines 411 are arranged at intervals along the annular direction of the groove portion 410 .

[0064] It can be understood that these raised lines 411 are evenly and spaced apart along the annular direction of the groove portion 410. On the one hand, by increasing the friction of the inner wall, they effectively prevent the experimental animals from losing balance due to slipping during running, which not only helps to ensure the smooth progress of the experiment, but also improves the comfort of the mice and encourages them to exhibit more natural behavior patterns; at the same time, this design effectively reduces the impact of larger movements caused by slipping, ensures the stability of the imaging area, significantly improves the clarity and accuracy of brain imaging, and provides scientific researchers with more reliable experimental data.

[0065] In some embodiments of this application, please refer to Figure 3 , Figure 3 The structure of the animal restraint device provided in this embodiment is schematically shown. The support base 100 of this embodiment includes a first base plate 110, a first universal ball platform 120, and a first universal ball 130. The first universal ball platform 120 is disposed on the first base plate 110 and has a first groove formed therein. The first universal ball 130 is partially received within the first groove and slidably connected to the groove wall of the first groove. A first connecting rod 140 is disposed on the portion of the first universal ball 130 disposed outside the first groove. The first connecting rod 140 is connected to the first connecting assembly 200 and the second connecting assembly 300.

[0066] It will be appreciated that the first universal ball 130 is partially embedded in the first groove and forms a sliding connection with the groove wall. This design enables the first universal ball 130 to rotate flexibly and stably within the groove, providing multi-directional adjustment capabilities for the support base 100. In addition, a first connecting rod 140 extends from the portion of the first universal ball 130 outside the groove. This connecting rod serves as a key connecting part 212 and is tightly connected to the first connecting assembly 200 and the second connecting assembly 300, thereby achieving a stable connection and coordinated operation between the support base 100 and other structural components.

[0067] In some embodiments, the first bottom plate 110 is provided with four screw holes 111, which can be used to mount the first bottom plate 110 on a test table. Specifically, the test table can be an optical platform.

[0068] In some embodiments, two fixing plates are provided on the first connecting rod 140 of the first universal ball 130 . Both fixing plates are provided with screw holes for fixing with the first connecting assembly 200 and the second connecting assembly 300 .

[0069] In some embodiments of this application, please refer to Figure 4 and Figure 5 , Figure 4 This embodiment provides Figure 1 A schematic diagram of the local A structure, Figure 5 The schematic diagram of the structure of the animal restraint device provided in this embodiment shows the first connecting assembly 200 of this embodiment. The first connecting assembly 200 includes a first connecting member 210, a shock absorber 220, and a second bottom plate 230. The first connecting member 210 is connected to the first connecting rod 140. The shock absorber 220 is disposed at the end of the first connecting member 210 away from the first connecting rod 140. The second bottom plate 230 is disposed on the side of the shock absorber 220 facing away from the first connecting member 210. The running disc 400 is disposed on the bottom plate, and a rotary bearing 600 is disposed between the running disc 400 and the bottom plate to enable the running disc 400 to rotate relative to the bottom plate.

[0070] It is understandable that the first connecting member 210 is responsible for establishing a firm connection with the first connecting rod 140 on the first universal ball 130, thereby transmitting the adjustment ability of the support base 100 to the subsequent structure. The shock absorber 220 is arranged at the end of the first connecting member 210 away from the first connecting rod 140. Its function is to effectively absorb and buffer vibrations or impacts from the external environment, protect the device from potential damage, and improve the accuracy of experimental data. The second bottom plate 230 serves as the support base of the running disc 400 and is arranged on the other side of the shock absorber 220. The running disc 400 is placed directly on the second bottom plate 230 and is flexibly rotated by the rotating bearing 600 arranged between the two. This design enables the running disc 400 to adjust its angle or position according to experimental requirements while ensuring the smoothness and accuracy of the rotation, which provides great convenience for the experiment.

[0071] In some embodiments, see Figure 6 , Figure 6 The schematic diagram of the animal restraint device provided in this embodiment shows a running disc base 700 disposed at the bottom of the running disc 400. The running disc base 700 is provided with a toothed groove structure 710, which is used to accommodate the rotating bearing 600. The running disc base 700 is provided with screw holes for connecting and securing to the second bottom plate 230.

[0072] In some embodiments of this application, please refer to Figure 7 , Figure 7 The structure of the animal restraint device provided in this embodiment is shown as a schematic diagram. The shock-absorbing member 220 of this embodiment includes a shock-absorbing spring 221 and a telescopic rod 222. The telescopic rod 222 is telescopically connected between the first connecting member 210 and the second bottom plate 230. The shock-absorbing spring 221 is sleeved outside the telescopic rod 222 and is connected to the first connecting member 210 and the second bottom plate 230.

[0073] It can be understood that the telescopic rod 222 is connected between the first connecting member 210 and the second bottom plate member 230 in a telescopic manner. When subjected to external force, the shock-absorbing spring 221 can absorb the impact energy, and the telescopic rod 222 can ensure that the shock-absorbing spring 221 only undergoes relative displacement in the up and down directions when working. It can eliminate the component of the stress generated during the movement of the mouse in the direction perpendicular to the plane of the running disc 400, while avoiding lateral deviation or shaking of the running disc 400, thereby maintaining the stability of the running disc 400 system.

[0074] In some embodiments, lubricating oil is added to the shock absorber 220 to prevent excessive friction from causing the spring shock absorber to malfunction.

[0075] In some embodiments, the upper and lower end seats of the shock absorber 220 each have a screw hole for fixing to the first connecting assembly 200 and the running plate 400.

[0076] In some embodiments of this application, please continue to refer to Figure 4 In this embodiment, at least four shock-absorbing springs 221 are provided, and at least four shock-absorbing springs 221 are distributed in a rectangular pattern.

[0077] It is understood that the provision of at least four damping springs 221 facilitates the coordinated absorption and dispersion of energy. This synergistic effect significantly enhances the shock absorption effect and effectively reduces the overall impact on the device. Furthermore, the at least four damping springs 221 are spaced in a rectangular pattern, ensuring that the load is evenly distributed across the bottom of the device, avoiding stress concentration caused by localized overload, thereby improving the stability and durability of the device.

[0078] In some embodiments of this application, please continue to refer to Figure 4The first connecting member 210 of this embodiment includes a first fixing portion 211, a connecting portion 212 and a second fixing portion 213 connected in sequence, the first fixing portion 211 is connected to the first connecting rod 140, and the shock absorber 220 is arranged on the second fixing portion 213; one end of the connecting portion 212 is connected to the first fixing portion 211, and the other end of the connecting portion 212 extends along a side close to the support base 100, and the other end of the connecting portion 212 is connected to the second fixing portion 213, so that the first fixing portion 211 and the second fixing portion 213 are parallel to each other and are not in the same plane.

[0079] It is understandable that the downwardly bent structure of the first connecting member 210 is beneficial to lowering the center of gravity of the running disc 400, thereby improving the stability of the animal fixing device.

[0080] In some embodiments of this application, please continue to refer to Figure 1 Also see Figure 8 , Figure 8 The schematic diagram of the structure of the animal securing device provided in this embodiment shows the second connecting assembly 300 of this embodiment. The second connecting assembly 300 includes a second connecting member 310 and a connecting rod 320. The second connecting member 310 is connected to the first connecting rod 140. A second universal ball base 323 is provided at the end of the second connecting member 310 away from the first connecting rod 140. A second universal ball is fixed to the second universal ball base 323. A second groove 325 is provided at one end of the connecting rod 320. The second universal ball is partially accommodated in the second groove 325. A third universal ball base 324 is provided at the end of the connecting rod 320 away from the second universal ball base 323. A third universal ball base 324 is provided with a third groove 326. A third universal ball is partially accommodated in the third groove 326. The second connecting rod is provided on the portion of the third universal ball exposed outside the third groove 326. The second connecting rod is connected to the securing member 500.

[0081] It can be understood that one end of the second connecting member 310 is rigidly connected to the first connecting rod 140, and the other end is integrated with the second universal ball table 323 and fixes the second universal ball. The second groove 325 at one end of the connecting support rod 320 forms a ball socket with the second universal ball, so that the connecting support rod 320 can swing around the second universal ball at multiple angles; the third universal ball table 324 and the third groove 326 set at the other end of the connecting support rod 320 constitute a secondary rotation joint with the third universal ball, and the second connecting rod extending from the exposed part of the third universal ball can be freely docked with the fixing member 500. The double universal ball structure is arranged in series in space, which is conducive to ensuring the posture adjustment ability of the device in three-dimensional space.

[0082] In some embodiments of this application, please continue to refer to Figure 8The connecting rod 320 of this embodiment includes a first rod 321 and a second rod 322 rotatably connected to each other. The first rod 321 is provided with a second universal ball table 323, and the second rod 322 is provided with a third universal ball table 324.

[0083] It can be understood that the second universal ball stage 323 is integrated at the end of the first support rod 321, and the third universal ball stage 324 is correspondingly set at the front end of the second support rod 322. This design, through the serial layout of the double universal ball stages and the rotatable support rods, enables the device to achieve planar rotation adjustment at the rotating joints of the first and second support rods, and can rely on the universal ball stages to achieve multi-angle swing in three-dimensional space, thereby constructing a composite motion freedom system, which is conducive to meeting the needs of fine-tuning the equipment posture during the experiment.

[0084] In some embodiments of this application, please refer to Figure 9 , Figure 9 A schematic structural diagram of the animal fixation device provided in this embodiment is shown; the fixing member 500 of this embodiment includes a fixing bracket 510 and a fixing ring 520, the fixing ring 520 is fixed on the fixing bracket 510, the fixing bracket 510 is detachably connected to the connecting support rod 320, and the fixing ring 520 is used to fix the head of the test animal.

[0085] It can be understood that the fixed bracket 510 is quickly assembled and separated from the end of the connecting rod 320 through a detachable interface (such as standardized connection methods such as bolts and snaps), which makes it easy to adjust the device layout according to the experimental scenario; the fixed ring 520 is fixed to the preset installation position of the fixed bracket 510 using rigid or elastic materials, and its inner diameter size is adapted to the contour of the head of the test animal. By adjusting the tightness of the ring body or adding a flexible pad, it can achieve a stable clamping while avoiding compression of the animal's respiratory and circulatory systems; this is conducive to ensuring the position stability of the animal's head during the experiment, and the detachable structure improves the adaptability of the device to multiple species.

[0086] In some embodiments of this application, please continue to refer to Figure 9 The fixing ring 520 of this embodiment has a first side portion for contacting the test animal. The first side portion is set as a curved structure along the annular direction of the fixing ring 520, and the curved structure is used to adapt to the upper part of the skull of the test animal.

[0087] It can be understood that the first side portion is configured as a curved structure along the annular direction of the fixing ring 520, which is conducive to better fitting the physiological curvature of the upper part of the mouse skull.

[0088] In some embodiments of this application, please continue to refer to Figure 9In this embodiment, a connecting groove portion 521 is provided on the first side portion, and the connecting groove portion 521 is communicated with the inner ring space of the fixing ring 520. The connecting groove portion 521 is used for perfusing and bonding the fixing colloid of the test animal.

[0089] It is understandable that the connection groove 521 can be filled with a fixing colloid to increase the bonding surface area with the mouse skull and increase the amount of fixing colloid, thereby facilitating improved fixation between the fixing ring 520 and the test animal.

[0090] In some embodiments, there are two connecting grooves 521 , and the two connecting grooves 521 are respectively provided on both sides of the fixing ring 520 .

[0091] In some embodiments, the connecting groove portion 521 is a semi-elliptical structure.

[0092] In some embodiments of this application, please continue to refer to Figure 9 In this embodiment, a protrusion 522 is provided on the outer ring wall of the fixing ring 520, and a fixing hole 523 is provided in the protrusion 522. The fixing hole 523 passes through the protrusion 522 along the axial direction of the fixing ring 520. The fixing hole 523 is used for infusing and bonding the fixing colloid of the test animal.

[0093] It is understandable that the fixing holes 523 can increase the amount of fixing colloid, which is beneficial to improving the fixation degree of the fixing ring 520 and the test animal.

[0094] In some embodiments of this application, please continue to refer to Figure 2 The animal fixing device of this embodiment includes a first knob screw 150 , which is used to pass through the first universal ball table 120 to the first groove and to abut against the first universal ball 130 .

[0095] It is understood that a screw hole is provided on the side of the first universal ball table 120 and is connected to the first groove. The first knob screw 150 is screwed into this screw hole and is able to contact the first universal ball 130 inside the first groove. When the first knob screw 150 is tightened, it applies pressure to the first universal ball 130, increasing the static friction, so that the first universal ball 130 is completely fixed and cannot rotate. Therefore, the first knob screw 150 can be adjusted to control whether the first universal ball 130 is completely fixed. When it is not completely fixed, the position and angle of the upper running disc 400 and the connecting rod 320 can be adjusted. When the adjustment is to the appropriate position, the first knob screw 150 can be directly tightened to fix the first universal ball 130.

[0096] In the examples of this application, please continue to refer to Figure 2The animal fixing device of this embodiment includes a second knob screw 327, which is used to pass through the first support rod 321 to the second groove 325 and to abut the second universal ball; the second universal ball can be loosened or tightened by the second knob screw 327 to adjust the rotation angle of the second universal ball.

[0097] In the examples of this application, please continue to refer to Figure 2 The animal fixing device of this embodiment includes a third knob screw 328 , which is used to pass through the second support rod 322 to the first support rod 321 to adjust the relative angle between the first support rod 321 and the second support rod 322 .

[0098] It will be appreciated that an unthreaded through-hole is defined in the upper portion of the second support rod 322, while a threaded hole of the same diameter is defined in the upper portion of the first support rod 321. These two holes are coaxial and connected by a third knob screw 328. The third knob screw 328 is installed in the screw hole in the upper portion of the first support rod 321. A first friction washer is placed between the holes in the second support rod 322 and the first support rod 321, and a second friction washer is placed between the second support rod 322 and the third knob screw 328. These friction washers increase the static friction between the two support rods when they are secured, further strengthening the securement. This allows the second support rod 322 to rotate freely relative to the first support rod 321 in a direction perpendicular to the plane of the third knob screw when the third knob screw is loose. However, when the third knob screw is tightened, the first support rod 321 is firmly fixed, thereby enabling adjustment of the position of the second support rod 322 relative to the first support rod 321.

[0099] In the examples of this application, please continue to refer to Figure 2 The animal securing device of this embodiment includes a fourth knob screw 329, which is configured to pass through the second support rod 322 and into the third groove 326, and to abut against the third universal ball. The third universal ball can be tightened or loosened by the fourth knob screw 329 to adjust its rotation angle.

[0100] In some embodiments, an opening is provided on the wall of the second groove 325 , and the opening is used to avoid the connecting rod on the second universal ball.

[0101] In some embodiments, an opening is provided on the wall of the third groove 326 , and the opening is used to avoid the second connecting rod.

[0102] Furthermore, in order to better implement the animal fixation device in any of the above-mentioned embodiments, based on the above-mentioned animal fixation device, the embodiment of the present application also provides an animal testing equipment, including a testing instrument, a test table and the animal fixation device as described above, the support base 100 of the animal fixation device is detachably connected to the test table, and the testing instrument is used to obtain test data of the test animal.

[0103] In the above embodiments, the description of each embodiment has its own focus. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant description of other embodiments.

[0104] The basic concepts have been described above. It will be apparent to those skilled in the art that the detailed disclosure above is merely illustrative and does not limit the present application. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and amendments to the present application. Such modifications, improvements, and amendments are suggested in the present application and remain within the spirit and scope of the exemplary embodiments of the present application.

[0105] At the same time, this application uses specific terms to describe the embodiments of this application. For example, "one embodiment," "an embodiment," and / or "some embodiments" refer to a certain feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that "one embodiment," "an embodiment," or "an alternative embodiment" mentioned twice or multiple times in different locations in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this application may be appropriately combined.

[0106] Similarly, it should be noted that, in order to simplify the presentation of this application and thus facilitate understanding of one or more embodiments of the invention, the foregoing descriptions of the embodiments of this application sometimes combine multiple features into a single embodiment, figure, or description thereof. However, this disclosure method does not mean that the subject matter of this application requires more features than those recited in the claims. In fact, an embodiment may have fewer features than all of the features of a single embodiment disclosed above.

[0107] The above-described embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present application, and should all be included in the scope of protection of the present application.

Claims

1. An animal fixing device, characterized in that: Used to fix experimental animals, the animal fixing device comprises: Support base; a first connecting assembly connected to the supporting base; a second connecting assembly connected to the support base; a running disc, the running disc being arranged at an end of the first connecting assembly away from the support base and being rotatable relative to the first connecting assembly; a groove being provided on a side of the running disc facing away from the first connecting assembly, at least a portion of an inner wall surface of the groove being a curved surface, the groove being used for allowing the test animal to run; A fixing member is provided at one end of the second connecting component away from the support base; wherein, the end of the second connecting component away from the support base is used to extend into the area where the groove portion is located to fix the head of the test animal on the running disc.

2. The animal securing device according to claim 1, characterized in that At least a portion of the inner wall surface of the groove portion is at least one of a spherical crown surface, an ellipsoidal crown surface, and a rotational paraboloid.

3. The animal securing device according to claim 1, characterized in that All inner wall surfaces of the groove portion are curved surfaces.

4. The animal securing device according to any one of claims 1 to 3, characterized in that: A plurality of raised lines are arranged on the inner wall surface of the groove portion, and the plurality of raised lines are arranged at intervals along the annular direction of the groove portion.

5. The animal securing device according to claim 1, wherein: The support base includes a first bottom plate, a first universal ball platform and a first universal ball. The first universal ball platform is arranged on the first bottom plate. A first groove is provided on the first universal ball platform. The first universal ball is partially accommodated in the first groove and is slidably connected to the groove wall of the first groove. A first connecting rod is provided on the part of the first universal ball arranged outside the first groove. The first connecting rod is connected to the first connecting component and the second connecting component.

6. The animal securing device according to claim 5, characterized in that The first connecting assembly includes a first connecting member, a shock absorbing member, and a second bottom plate member, wherein the first connecting member is connected to the first connecting rod, the shock absorbing member is arranged at an end of the first connecting member away from the first connecting rod, and the second bottom plate member is arranged on a side of the shock absorbing member away from the first connecting member; Wherein, the running disc is arranged on the bottom plate, and a rotary bearing is provided between the running disc and the bottom plate, so that the running disc can rotate relative to the bottom plate.

7. The animal securing device according to claim 6, characterized in that The shock absorbing member includes a shock absorbing spring and a telescopic rod, wherein the telescopic rod is telescopically connected between the first connecting member and the second bottom plate member; the shock absorbing spring is sleeved outside the telescopic rod, and the shock absorbing spring is connected to the first connecting member and the second bottom plate member.

8. The animal securing device according to claim 7, characterized in that The shock absorbing springs are provided in at least four configurations, and the at least four shock absorbing springs are distributed in a rectangular pattern.

9. The animal securing device according to claim 6, wherein: The first connecting member includes a first fixing portion, a connecting portion, and a second fixing portion connected in sequence, the first fixing portion is connected to the first connecting rod, and the shock absorber is arranged on the second fixing portion; one end of the connecting portion is connected to the first fixing portion, and the other end of the connecting portion extends along a side close to the support base, and the other end of the connecting portion is connected to the second fixing portion, so that the first fixing portion and the second fixing portion are parallel to each other and are not in the same plane.

10. The animal securing device according to claim 5, characterized in that The second connecting assembly includes a second connecting member and a connecting rod, wherein the second connecting member is connected to the first connecting rod, a second universal ball table is provided on an end of the second connecting member away from the first connecting rod, a second universal ball is fixed to the second universal ball table, and a second groove is provided at one end of the connecting rod, and the second universal ball is partially accommodated in the second groove; A third universal ball joint is provided on the end of the connecting support rod away from the second universal ball joint, a third groove is provided on the third universal ball joint, a part of a third universal ball is provided in the third groove, a second connecting rod is provided on the part of the third universal ball exposed outside the third groove, and the second connecting rod is connected to the fixing member.

11. The animal securing device according to claim 10, characterized in that The connecting support rod comprises a first support rod and a second support rod which are rotatably connected to each other, the first support rod is provided with the second universal ball platform, and the second support rod is provided with a third universal ball platform.

12. The animal securing device according to claim 11, characterized in that The fixing member comprises a fixing bracket and a fixing ring, wherein the fixing ring is fixed on the fixing bracket, the fixing bracket is detachably connected to the connecting rod, and the fixing ring is used to fix the head of the test animal.

13. The animal securing device according to claim 12, wherein: The fixing ring has a first side portion for contacting the test animal. The first side portion is arranged in a curved structure along the annular direction of the fixing ring. The curved structure is adapted to fit the upper part of the skull of the test animal.

14. The animal securing device according to claim 13, wherein: The fixing ring satisfies at least one of the following conditions: The first side portion is provided with a connecting groove portion, the connecting groove portion is communicated with the inner ring space of the fixing ring, and the connecting groove portion is used for perfusing and bonding the fixing colloid of the test animal; A convex portion is provided on the outer ring wall of the fixing ring, and a fixing hole is provided in the convex portion. The fixing hole passes through the convex portion along the axial direction of the fixing ring, and the fixing hole is used for perfusing and bonding the fixing colloid of the test animal.

15. The animal securing device according to any one of claims 11 to 14, characterized in that The animal securing device satisfies at least one of the following: The animal fixing device includes a first knob screw, the first knob screw is used to pass through the first universal ball table to the first groove, and is used to abut against the first universal ball; The animal fixing device includes a second knob screw, the second knob screw is used to pass through the first support rod to the second groove, and is used to abut against the second universal ball; The animal fixing device includes a third knob screw, and the third knob screw is used to pass through the second support rod to the first support rod to adjust the relative angle between the first support rod and the second support rod; The animal fixing device includes a fourth knob screw, which is used to pass through the second support rod to the third groove and abut against the third universal ball.

16. An animal testing device, characterized in that: It comprises a testing instrument, a testing table and the animal fixing device according to any one of claims 1 to 15, wherein the supporting base of the animal fixing device is detachably connected to the testing table, and the testing instrument is used to obtain test data of the test animal.

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