Powdered supported MCT compositions and uses thereof
By using high-glycoprotein gum arabic as a carrier material to form a core/shell structured particle composition, the problems of stability and high loading of the oil phase or fat phase in food, cosmetics and medicines are solved, and high-content loading and uniform dispersion of medium-chain triglycerides are achieved, thereby improving the stability and bioavailability of the product.
Patent Information
- Application Number
- CN202380094855.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-03-09
- Filing Date
- 2023-03-15
- Publication Date
- 2025-10-03
AI Technical Summary
In the existing technology, it is difficult to emulsify the oil phase or fat phase uniformly and stably in food, cosmetics and medicines, resulting in insufficient stability and low bioavailability. In addition, commonly used carrier materials such as modified starch and maltodextrin have heat effects and solubility problems, making it impossible to achieve high loading amounts.
Gum arabic with a high glycoprotein content is used as a polysaccharide-based carrier material to form a core/shell structured particle composition to achieve high loading and stable emulsification of medium-chain triglycerides, avoiding the shortcomings of traditional carrier materials.
A high content loading of medium-chain triglycerides is achieved, the stability and bioavailability of the product are improved, the dispersibility and fluidity of the composition in the liquid are ensured, and it is suitable for a variety of product forms.
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medium chain triglycerides (also synonymously referred to as MCTs), and in particular to providing such triglycerides in specific compositions.
[0002] In particular, the present invention relates to a composition, in particular a granular composition, comprising medium chain triglycerides (MCT) and which is preferably in powder form, in particular for use in food or foodstuffs, cosmetics or pharmaceuticals, wherein the composition comprises or consists of a plurality of individual granules, and wherein the granules comprise at least one polysaccharide-based carrier (i.e. support) material based on gum arabic.
[0003] Furthermore, the present invention also relates to related foods, cosmetics or pharmaceuticals, each comprising the composition according to the present invention.
[0004] Furthermore, the present invention also relates to the use of the composition according to the invention in foods, cosmetics or pharmaceuticals, or for the preparation of foods, cosmetics or pharmaceuticals.
[0005] Furthermore, the present invention relates to a process for preparing the composition according to the invention.
[0006] The present invention also relates to a method for controlling or regulating the loading of a polysaccharide-based carrier material comprising or formed from gum arabic with at least one medium-chain triglyceride (MCT), said method being particularly useful for preparing a granular or powdered composition comprising a medium-chain triglyceride (MCT) as defined herein.
[0007] Finally, the present invention also relates to the use of a polysaccharide-based carrier (ie support) material comprising or formed from gum arabic for controlling or regulating the loading of the polysaccharide-based carrier material with at least one medium-chain triglyceride (MCT). Background Art
[0008] In the prior art, oil and fat phases or fats (e.g., triglycerides) are frequently used, particularly in the food industry, as well as in the cosmetic and pharmaceutical industries, to impart specific properties to products or articles. This is usually done based on the physical or physicochemical properties of the substances used and their nutritional or metabolic relevance, particularly in the case of food. However, a common problem is that the oil or fat phase in pure form cannot always be satisfactorily incorporated into the corresponding product.
[0009] In this context, it is often difficult to effectively incorporate the oil or fat phase into the corresponding product in order to achieve both a high content and a stable or homogeneous emulsification. Emulsification of the oil or fat phase in a homogeneous and stable manner is often not possible. This results in, for example, separation of components or systems, with consequently insufficient (storage) stability and ultimately limited product quality. Consequently, it is impossible to specify or permanently maintain the properties of the corresponding product to an adequate degree. Furthermore, the bioavailability of the underlying components is often low.
[0010] Against this background, there is therefore a great overall demand for state-of-the-art technology to provide relevant products, in particular in the form of homogeneous and stable dispersions, in particular emulsions, in which a stable, homogeneous and permanent incorporation of an oily or fatty phase is achieved, so that also high contents or concentrations of oil or fat can be achieved.
[0011] Against this background, the state of the art is exploring methods for applying, fixing or coating the oily or fatty phases for the corresponding products or preparations on carriers or carrier materials in order to improve handling and incorporation. Such supported or coated systems generally offer better handling and processing of the dispersions or emulsions to be prepared than free, and in particular unsupported or uncoated, oily or fatty phases.
[0012] For supported or encapsulated oil or fat phase systems, generally, a large amount of available oil or fat phase is used along with the material used to form the carrier system or encapsulation.
[0013] In addition to numerous other materials, polysaccharide-based carrier materials are also used in the prior art as carrier materials, with the focus in this context generally being on the use of modified starches and maltodextrins, among others. However, with such carrier systems, the corresponding oil or fat phase can usually only be fixed or attached to a certain extent. Such carrier systems are usually in granular form. Compositions obtained based on loaded carrier systems do not always have an optimal oil or fat phase loading. Furthermore, the application and processing properties of such compositions based on carrier materials formed from modified starches or maltodextrins are generally not always optimal. Furthermore, stability is not always good, and fluidity or pourability are generally not very good. Furthermore, such compositions are prone to caking or forming large agglomerates, especially at high oil or fat phase loading levels, as the underlying granular structure sometimes has a certain stickiness.
[0014] Overall, the storage stability of prior art carrier systems is often unsatisfactory. Furthermore, due to the aforementioned drawbacks, prior art loading or encapsulation systems often behave in such a way that they are often not optimally incorporated or processed into products or articles (e.g., food, cosmetic, and pharmaceutical products or articles) in terms of forming stable, homogeneous dispersions. This results in inferior product properties for the resulting products or articles, including stability, oil or fat content, bioavailability of ingredients, and application performance.
[0015] Furthermore, it should be noted, in particular in the field of food or related products or preparations, that carrier materials based on modified starches or maltodextrins are not nutritionally neutral and may also have their own caloric impact in this context, which is problematic or undesirable for example in dietary foods. Furthermore, when added to liquids, especially water, their solubility is generally poor, which is not conducive to the formation of substantially stable or homogeneous emulsions.
[0016] Gum arabic can also be used as a polysaccharide-based carrier or carrier material. Gum arabic is particularly advantageous in terms of emulsification. However, conventional gum arabic used in the prior art generally cannot achieve the desired high loadings of the oil or fat phase, as the loading capacity in this regard is generally insufficient. This means that products based on or incorporating such compositions cannot have the desired high oil or fat content. Consequently, attempts have been made to combine gum arabic with other materials in carrier systems, or to use other carrier systems including, for example, modified starch or maltodextrin as additional carrier materials, but this is associated with the aforementioned disadvantages.
[0017] The scientific publication "Microencapsulation of cardamom oleoresin: Evaluation of blends of gum arabic, maltodextrin, and a modified starch wall materials" by Savihta Krishnan et al. (Carbohydrate Polymers, Vol. 61, No. 1, July 4, 2005, pp. 95-102) discusses the microencapsulation of cardamom oleoresin and the related analysis of mixtures of gum arabic, maltodextrin, and modified starch. Microencapsulation is specifically based on the formation of binary and ternary mixtures of these components. Therefore, the focus is on hybrid systems for capsule formation. The use of binary or ternary mixtures has certain disadvantages, as previously mentioned for the corresponding substances.
[0018] As mentioned above, many possible carrier materials for the oil or fatty phase are used in the prior art.
[0019] In this context, US Pat. No. 1,046,3626 B2 relates to a dry composition comprising three-dimensional porous microparticles. The microparticles comprise an active ingredient, polymer nanoparticles, lipid droplets, a nanoparticle stabilizer, and a cryoprotectant, with the active ingredient being carried by the nanoparticles or lipid droplets. The nanoparticles used as a carrier material are based on PLGA polymer (poly(lactide-co-glycolide)).
[0020] Furthermore, the scientific publication "High-Oil-Load Encapsulation of Medium-Chain Triglycerides and d-Limonene Mixture in Modified Starch by Spray Drying" by Vita Paramita et al. (Journal of Food Science, Vol. 77(2), pp. E38 to E44) relates to encapsulating a mixture of medium-chain triglycerides and d-limonene in modified starch. In this regard, modified starch is therefore used as a carrier material. As mentioned above, the use of modified starch has some disadvantages.
[0021] In general, it can be said that prior art carrier materials for absorbing or immobilizing oily or fatty phases, as well as compositions based on such carrier systems, do not always achieve high levels of oily or fatty phase loading, and that such systems or compositions do not always achieve optimal application and use. Compositions do not always exhibit optimal application and processing properties, particularly with respect to providing corresponding products or preparations (e.g., foods, pharmaceuticals, or cosmetics) or forming stable or homogeneous emulsions. Furthermore, the systems or compositions in question do not always exhibit optimal metering properties.
[0022] Medium-chain triglycerides (MCT) are very important in the fields of food, cosmetics and pharmaceutical products because of their special properties. Medium-chain triglycerides are commonly used in the production of cosmetics and pharmaceuticals, for example as carriers, solubilizers, release agents, lubricants, etc. for other ingredients or components. In addition, medium-chain triglycerides (MCT) are also commonly used in the food industry, including dietary foods, for example, due to their metabolic properties or special properties. Therefore, the demand for medium-chain triglycerides is also very high, and is used to provide corresponding products or products in the form of uniform or stable dispersions (particularly emulsions), thereby giving medium-chain triglycerides, especially with respect to food, a uniform distribution or high content or high concentration and high bioavailability, while also having high storage stability. However, using the carrier systems available in the prior art and compositions comprising such carrier systems, satisfactory results cannot always be obtained with medium-chain triglycerides due to the above-mentioned shortcomings. Summary of the Invention
[0023] Against this background, it was an object of the present invention to provide a carrier system or a composition comprising such a carrier system for receiving or immobilizing an oily or fatty phase, in particular medium-chain triglycerides (MCT), which at least to a large extent avoids or at least alleviates the disadvantages of the previously described prior art.
[0024] Specifically, a carrier system or composition is provided that can effectively absorb or immobilize an oil phase and a fat phase, particularly medium-chain triglycerides (MCTs), thereby enabling the carrier system or composition as a whole to be highly loaded with medium-chain triglycerides (MCTs). The carrier system or composition should also have improved handling and use properties or processing properties, particularly when used and applied to other products or articles, and should be in the form of a stable and uniform dispersion (particularly an emulsion), or can also be in the form of a solid or powder.
[0025] Surprisingly, the applicant has found in the context of the present invention that it is possible to provide compositions provided with or loaded with a high content of medium-chain triglycerides (MCTs) if particles based on a special carrier material, in particular for binding or immobilizing medium-chain triglycerides (MCTs), are used, i.e. in the form of a polysaccharide-based carrier material comprising or formed therefrom in a special manner, wherein the gum arabic has a high glycoprotein content, as will be described in detail below.
[0026] Due to the targeted and purposeful use of a specific gum arabic-based carrier material, the processing or application of medium-chain triglycerides (MCT) on the carrier material can be improved in a completely unexpected manner, and a large amount of medium-chain triglycerides (MCT) can be absorbed by the composition or fixed on the particles. According to the present invention, a special composition with a high proportion or high content of medium-chain triglycerides (MCT) is thus provided, which can achieve overall improved product and application properties of the composition, as will also be explained below. In this context, the composition of the present invention is also suitable for use in a wide range of products in the food or food industry as well as in the cosmetic or pharmaceutical industry.
[0027] In order to solve the above-mentioned objects, according to a first aspect of the present invention, the present invention thus proposes a composition according to claim 1, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form containing medium-chain triglycerides (MCT); in addition, in particular, special and / or advantageous embodiments of the composition according to the present invention are the subject matter of the dependent claims related to the composition.
[0028] Furthermore, according to a second aspect of the present invention, the present invention relates to a food, cosmetic or pharmaceutical product comprising the composition according to the present invention according to the independent claim relating to the product according to the present invention; moreover, in particular specific and / or advantageous embodiments of this aspect of the invention are the subject matter of the dependent claims relating to the product according to the present invention.
[0029] Similarly, according to the third aspect of the present invention, the present invention also relates to the use of the composition of the present invention in a food, cosmetic or pharmaceutical product, or for the preparation of a food, cosmetic or pharmaceutical product, according to the independent claims related to the use of the composition of the present invention; moreover, in particular, specific and / or advantageous embodiments of this aspect of the invention are the subject matter of the dependent claims related to the use of the present invention.
[0030] Furthermore, according to a fourth aspect of the present invention, the present invention relates to a method according to the invention for preparing a composition according to the independent claim associated with the method according to the invention, the composition being in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium-chain triglycerides (MCT); moreover, in particular, specific and / or advantageous embodiments of this aspect of the invention are the subject matter of the dependent claims associated therewith.
[0031] Furthermore, according to a fifth aspect of the present invention, the present invention relates to a method according to the invention for controlling or regulating the loading (in particular the loading amount) of a polysaccharide-based carrier material comprising gum arabic or formed therefrom for at least one medium-chain triglyceride (MCT) according to the independent claim associated therewith; moreover, in particular, specific and / or advantageous embodiments of this aspect of the invention are the subject matter of the dependent claims associated therewith.
[0032] Furthermore, according to a sixth aspect of the present invention, the present invention relates to the use of the glycoprotein content of a polysaccharide-based carrier material comprising or formed from gum arabic according to the independent claim relating to the use according to the present invention, for controlling and / or setting the loading (in particular the loading amount) of the polysaccharide-based carrier material with at least one medium-chain triglyceride (MCT); moreover, in particular, specific and / or advantageous embodiments of the use according to the present invention according to this aspect are the subject matter of the dependent claims relating thereto. DETAILED DESCRIPTION
[0033] In the following description, it goes without saying that the embodiments, advantages, etc. described below for only one aspect of the present invention to avoid repetition naturally also apply to other aspects of the present invention accordingly, and there is no need to mention them separately.
[0034] Furthermore, it goes without saying that individual aspects and embodiments of the invention are also considered to be disclosed in any combination with other aspects and embodiments of the invention, and in particular, any combination of features and embodiments that can be derived from the backreferences of all patent claims is also considered to be disclosed broadly (i.e. with respect to all resulting combination possibilities).
[0035] In particular, for features that characterize the invention, any combination of these features is also considered disclosed, wherein embodiments of the individual features of the same priority are preferred in their combination (e.g., the number or amount range of related components of the same priority, etc.). Likewise, all other combinations (i.e., combinations based on different priorities or different priority levels) are also disclosed.
[0036] In all cases of relative or percentage weight-related disclosures mentioned below (in particular relative quantity or weight disclosures), it should also be noted that these are selected by the person skilled in the art within the scope of the present invention in such a way that, when all components or ingredients are included, these always add up to 100% or 100 wt.%, in particular as defined below; however, this is self-evident for the skilled person.
[0037] Furthermore, a skilled person may deviate from the numerical values or ranges of the present amounts or contents of the following ingredients or components as necessary depending on the application or individual case without departing from the scope of the present invention.
[0038] Furthermore, all values or parameters etc. mentioned below can in principle be determined using standardized or well-defined determination methods or in other ways using determination or measurement methods known to a person skilled in the art.
[0039] With this stipulation, the invention will be described in detail below: According to a first aspect of the invention, the subject of the invention is therefore a composition according to the invention, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular for use in cosmetic, pharmaceutical or food products,
[0040] wherein the composition comprises or consists of a plurality of individual particles,
[0041] Each particle comprises at least one polysaccharide-based carrier (i.e., support) material, wherein the polysaccharide-based carrier material is provided with and / or loaded with at least one medium-chain triglyceride (MCT), in particular, is provided with and / or loaded with at least one linear saturated C6, C8, C 10 or C 12 at least one triglyceride of a carboxylic acid, and / or wherein each particle comprises at least one polysaccharide-based carrier material and at least one medium-chain triglyceride bound and / or immobilized to the polysaccharide-based carrier material, and / or wherein each particle comprises at least one polysaccharide-based carrier material and at least one medium-chain triglyceride (MCT) bound and / or immobilized to the polysaccharide-based carrier material, in particular at least one linear saturated C6, C8, C 10 or C 12 at least one triglyceride of a carboxylic acid;
[0042] wherein the polysaccharide-based carrier material comprises or is formed from gum arabic, wherein the gum arabic comprises a glycoprotein content of at least 4 wt.%, and preferably in the range of 4 wt.% to 25 wt.%, based on the gum arabic, and
[0043] Wherein, the composition or granule comprises a triglyceride content of at least 50 wt.%, and preferably in the range of 50 wt.% to 90 wt.%, based on the composition or granule.
[0044] Surprisingly, the applicants have discovered an efficient and effective method for providing a composition having a high amount or content of medium-chain triglycerides by providing a granular composition or a composition in powder form in a targeted and purposeful manner by using a specific polysaccharide-based carrier material, which in turn comprises or is formed from a specific gum arabic, whereby, within the scope of the present invention, the gum arabic has a high glycoprotein content.
[0045] In this context, it is also unexpected and surprising in the context of the present invention that, by using gum arabic with a high glycoprotein content, a large amount of medium-chain triglycerides can be bound or fixed to a polysaccharide-based carrier material, while a large amount of powdered medium-chain triglycerides can be bound or fixed to a polysaccharide-based carrier material. At the same time, the composition of the present invention also has excellent dispersibility, particularly emulsification, in liquids (particularly in water), so that on this basis, a product or final product (e.g., particularly a food, cosmetic or pharmaceutical product) in the form of a uniform and stable dispersion, particularly an emulsion with a higher MCT content can be obtained. The excellent performance of the composition of the present invention in terms of dispersibility (particularly emulsification) is also surprising, because a high content of medium-chain triglycerides can fundamentally impair performance in this regard. The composition according to the present invention is also designed to be free-flowing and flowable and can be easily incorporated into a composition in powder form or processed into a product, particularly uniformly and without the need to use high mixing and / or shearing energy.
[0046] In this context, the polysaccharide-based carrier material based on a special gum arabic with a high glycoprotein content used according to the present invention is particularly important. Without wishing to be bound or restricted by this theory, the gum arabic used according to the present invention acts as a particularly intrinsic dispersant, particularly an emulsifier, for medium-chain triglycerides, and this effect manifests itself in several ways: on the one hand, when the composition or carrier material is loaded with medium-chain triglycerides; and on the other hand, within the scope of the application or use of the composition of the present invention, when a dispersion (particularly an emulsion) is formed by introducing the composition into a liquid (particularly water) to form the corresponding product. In this context—again without wishing to be bound or restricted by this theory—the gum arabic component based in particular on the corresponding glycoprotein and the medium-chain triglycerides (MCT) have an optimal interaction for fixing or binding the MCT to the polysaccharide-based carrier material and for the subsequent formation of a dispersion, particularly an emulsion. This generally improves the binding and loading properties and also leads to good release properties when the composition is introduced into a liquid, such as water, to form a dispersion (particularly an emulsion).
[0047] In addition, the granular composition or powdered composition of the present invention also exhibits excellent flowability. This is also closely related to the good controllability of the present composition during preparation and the good controllability of the present composition during its application or processing, and is particularly closely related to aspects such as excellent doseability and avoidance of caking or large agglomerate formation. On this basis, a homogeneous (final) product can be provided based on a stable and uniform dispersion (particularly an emulsion based on the present composition). Particularly surprising is that, although the composition of the present invention has a high loading or high content of medium-chain triglycerides (MCT), it does not exhibit any particle stickiness or adhesion that is contrary to flowability or pourability. Therefore, the composition of the present invention can be easily, particularly evenly and without the need to use large mixing and / or shearing energy, incorporated into a powdered composition or processed into a powdered product.
[0048] Specifically, based on the composition of the present invention, the corresponding (final) product (such as food, cosmetic or pharmaceutical product) can have a high content of medium chain triglycerides (MCT), which is also accompanied by other core advantages, especially due to the excellent properties of medium chain triglycerides (MCT), such as as a carrier, solubilizer, release agent, lubricant, hydrophobic agent, film-forming and protective agent and viscosity regulator, etc. On this basis, corresponding products with optimized properties can be provided.
[0049] In addition, medium-chain triglycerides have excellent nutritional and metabolic properties, which can also improve the relevant properties of corresponding (food) products.
[0050] In general, based on the composition of the present invention, the incorporation of medium-chain triglycerides (MCTs) into formulations to obtain corresponding products can be facilitated or improved.
[0051] By having a high content of medium-chain triglycerides (MCT) in the corresponding products or preparations, good care properties and application properties can be provided, for example in the case of cosmetics (for example, creams etc. spread well on the skin).
[0052] In this context, medium-chain triglycerides (MCTs) are also highly bioavailable, especially because they are homogeneously distributed in ready-to-use products and incorporated into stable dispersions, especially emulsions.
[0053] The compositions of the present invention also have the advantage of being particularly vegan. Furthermore, the compositions of the present invention can be at least substantially tasteless and / or odorless, or at least substantially colorless. In particular, the compositions of the present invention also have high stability, particularly storage stability. In this context, the compositions of the present invention can have a storage stability of at least 36 months at a storage temperature below 25°C in dry air (i.e., relative humidity below 60%), particularly when stored or preserved in a sealed and / or moisture-proof and / or opaque container.
[0054] Furthermore, in the context of the present invention, due to the high content of medium-chain triglycerides (MCTs), the compositions of the present invention also have a correspondingly high ketone body index (ketogenic index), and accordingly, corresponding products or preparations with a similarly high ketone body index can also be provided on this basis. In this context, for example, with respect to the use of the compositions of the present invention in food or dietary foods, the compositions of the present invention also have a correspondingly high nutritional-physiological or dietary relevance. This is because the physiological metabolism of medium-chain triglycerides (MCTs) in the human body forms ketones or ketone bodies, which has corresponding nutritional-physiological relevance, for example, in terms of diet, special nutrition, etc. In particular, on this basis, relevant compositions, products, or preparations with a high energy density can also be provided.
[0055] Composition of the present invention can be used for example described under ointment, emulsifiable paste, lotion, gel, spray or liquid dosage form.Composition of the present invention can also be used for product or goods based on dry preparation (particularly powdered preparation), particularly because it has good miscibility.Especially, be suitable for dry or powdered cosmetic product (for example shampoo, shower gel, skin care product etc.).But powdered preparation or the product based on dry preparation (particularly powdered preparation) also can be considered for food and food products and pharmaceutical field.
[0056] If necessary or desired, the user can add a liquid, in particular water. Due to its excellent dispersibility, in particular emulsification, the addition of a liquid (in particular water) results in the immediate formation of a homogeneous dispersion (in particular an emulsion) that is ready for use.
[0057] In this context, the composition of the present invention also has the advantage that upon addition of a liquid, particularly water (or a solvent), an emulsion is immediately obtained, even without further heating. Therefore, in this context, the composition of the present invention is also particularly effective for converting a composition or powder into a stable, homogeneous emulsion upon addition of a liquid, particularly water ("from powder to emulsion"). On this basis, the present invention facilitates the incorporation of MCT into products, and can also be used in formulations containing surfactants ("from powder to surfactant"). The composition of the present invention can also be added to powdered formulations, such as granular or powdered and / or essentially anhydrous skin and hair cleansing products, particularly (dry) shampoos or (dry) shower gels. In particular, the composition of the present invention can also be added to formulations based on balms, spray-dried emulsions, or mixtures of various oils. Such formulations can also contain high MCT contents, thereby improving the care properties of cosmetic products, particularly in powdered formulations. In this context, the disadvantage of the present invention, namely, the inability to achieve high oil or lipid phase contents, particularly in granular or powdered formulations or at least essentially anhydrous products, can be overcome. In this context, the present invention also makes a valuable contribution to the development or provision of products or articles (e.g., skin care products) that use at least essentially no water during the manufacturing process, with water added only upon application or use by the consumer to form an emulsion. Due to its excellent properties, this process can also be carried out at room temperature. This also contributes to sustainability. Based on this, corresponding emulsions can be formed that can, for example, be applied to the skin and exhibit excellent care properties in this regard. In particular, as mentioned above, high MCT contents can be achieved in this context.
[0058] In summary, it should be emphasized that the concept of the present invention (using a specific gum arabic to provide a corresponding polysaccharide-containing carrier material for medium-chain triglycerides (MCTs)) surprisingly allows for high loadings of medium-chain triglycerides (MCTs), i.e., triglyceride contents of at least 50% by weight in the compositions of the present invention. At the same time, excellent flow properties are achieved in the compositions of the present invention, and stable dispersions or emulsions can be formed when the compositions of the present invention are used. The gum arabic used according to the invention has a high glycoprotein content of at least 4% by weight, preferably in the range of 4% to 25% by weight, based on the gum arabic.
[0059] With regard to particles based on a polysaccharide-based carrier material and at least one medium-chain triglyceride (MCT), they can exist in any form or any physical structure. Specifically, these particles can form matrix particles, particularly when the carrier material forms a matrix for accommodating medium-chain triglycerides (MCT). In this regard, medium-chain triglycerides (MCT) can be embedded in or incorporated into a matrix or carrier material, and / or deposited on a matrix or carrier material; in principle, the matrix can be porous or continuous or dense. In addition, particles based on a polysaccharide-based carrier material and at least one medium-chain triglyceride (MCT) can also be formed into capsule particles, particularly core / shell capsules (core / shell structure). In this regard, it is particularly conceivable that the polysaccharide-based carrier material forms a capsule shell that encapsulates medium-chain triglycerides (MCT) (whereby additional medium-chain triglycerides can also be present on or at the outer capsule surface).
[0060] According to a preferred embodiment of the present invention, it can be provided that the particles of the composition according to the invention each comprise a plurality of elementary particles (= elementary particles) and / or are formed from a plurality of elementary particles (= elementary particles), in particular wherein the elementary particles are bound to one another and / or aggregated, and / or in particular wherein the elementary particles each comprise or are formed from at least one medium-chain triglyceride and gum arabic, preferably each have a core / shell structure and / or are preferably each core / shell elementary particles, preferably wherein the core comprises or is formed from at least one medium-chain triglyceride and the shell comprises or is formed from gum arabic. According to a preferred embodiment, in particular in the case of a high MCT loading, it can be particularly optionally provided that at least one medium-chain triglyceride is additionally present on or at the surface of the core / shell structure and / or the core / shell base particle, in particular on the shell (i.e. as so-called "free" surface oil, the proportion or content of which can be determined analytically, in particular by solvent extraction with a generally lipophilic solvent such as diethyl ether); in this case, the content of medium-chain triglycerides present on or at the surface of the core / shell structure and / or the core / shell base particle (in particular on the shell), based on the particle, is in particular from 5 wt.% to 60 wt.%, preferably from 10 wt.% to 55 wt.%, preferably from 15 wt.% to 50 wt.%, particularly preferably from 20 wt.% to 45 wt.%.
[0061] According to a preferred embodiment of the present invention, it can also be provided that the particles of the composition of the present invention each comprise and / or are formed of a plurality of elementary particles (= base particles) connected to and / or aggregated with one another, in particular, wherein the elementary particles each comprise or are formed of at least one medium-chain triglyceride and gum arabic, preferably each have a core / shell structure and / or are preferably each a core / shell elementary particle, preferably, wherein the core comprises or is formed of at least one medium-chain triglyceride and the shell comprises or is formed of gum arabic. According to a preferred embodiment, in particular in the case of high MCT loadings, it can be particularly optionally provided that at least one medium-chain triglyceride is additionally present on or at the surface of the core / shell structure and / or the core / shell base particle, in particular on the shell (i.e. as so-called "free" surface oil, the proportion or content of which can be determined analytically, in particular by solvent extraction with a generally lipophilic solvent such as diethyl ether); in this case, the content of medium-chain triglycerides present on or at the surface of the core / shell structure and / or the core / shell base particle (in particular on the shell), based on the particle, is in particular 5 wt.% to 50 wt.%, preferably 10 wt.% to 40 wt.%, preferably 15 wt.% to 30 wt.%.
[0062] The gum arabic used in the present invention has further improved properties as an emulsifier and stabilizer for the medium-chain triglycerides (MCTs) used in the present invention. Furthermore, gum arabic is generally well tolerated because it is non-toxic and non-allergenic. Furthermore, gum arabic is physiologically inert, so that after absorption by the human body, it is at least substantially not metabolized. Therefore, for example, when used in food products or similar products, no additional calories are consumed, and the ketone metabolism associated with MCTs is not disturbed. This is particularly beneficial for the formation of ketone bodies. Furthermore, the gum arabic used in the present invention is a purely vegan substance or a natural raw material with a well-defined composition.
[0063] Generally speaking, gum arabic (also synonymously referred to as acacia) refers to a gum that comes from the exudates of various species of the acacia tree, which are particularly widespread in Africa.
[0064] Generally, gum arabic contains polysaccharides, in particular acidic alkali or alkaline earth metal salts based on arabic acid or polyarabic acid. In addition, gum arabic also contains glycoproteins (in particular arabinogalactan protein and other glycoproteins, i.e. glycoproteins other than arabinogalactan protein).
[0065] As mentioned above, gum arabic is usually obtained from the exudates or wound juices of trees. Specifically, it can be obtained by cutting into the peeled bark at a downward angle. In 20 to 30 days, the gum that oozes out will form hard bubbles, or worm-like or angular fragments, which can then be taken out or gathered in the crops. However, trees also ooze out gum voluntarily, especially when the bark cracks because of drying. The resulting material can be further dried and subjected to further processing steps, such as purification steps, etc.
[0066] As will be explained in more detail below, the present invention, according to one embodiment of the present invention, relates in particular to the use of a very specific gum arabic, in particular obtained from or derived from the gum arabic tree (Acacia senegalensis, or, equivalently, Acacia senegalensis). In this regard, the applicants have surprisingly discovered that this specific gum arabic has a correspondingly high content of glycoproteins and is therefore particularly suitable for use as a polysaccharide-based carrier material for the compositions of the present invention.
[0067] Gum arabic is specifically described or characterized by the CAS number (CAS Registry Number) 9000-01-5.
[0068] In the European Union, gum arabic has been approved as a food additive with the E number E 414.
[0069] For more details on gum arabic, see Chemie Lexikon (10th edition, volume 2, GeorgThieme Verlag, Stuttgart / New York, 1997, pp. 1625-1626, keyword: "Gum arabicum") and literature cited therein.
[0070] The glycoproteins, whether provided by gum arabic or present in gum arabic (especially naturally occurring), are generally (macro)molecules based on proteins or protein residues or groups to which one or more carbohydrate groups (i.e., glycosyl groups) are bound (especially covalently bound). In other words, the glycoproteins provided by gum arabic are generally glycosylated proteins, i.e., proteins or protein residues or groups to which carbohydrate groups or residues (i.e., glycosyl groups or residues) are bound. In principle, carbohydrate groups or residues are of a wide variety, ranging from monosaccharides to disaccharides, from oligosaccharides to polysaccharides, and therefore, in the present invention, oligosaccharide groups and especially polysaccharide groups are present as carbohydrate groups of the corresponding glycoprotein.
[0071] Specifically, the term "glycoprotein" as used in the context of the present invention refers collectively to all glycoproteins present. In other words, the term "glycoprotein" as used in the context of the present invention is a general or collective term for all glycoproteins present in gum arabic used in the present invention. Thus, this specifically includes arabinogalactan protein as a specific glycoprotein present in gum arabic used in the present invention, and also includes all other glycoproteins present in gum arabic used in the present invention (i.e., glycoproteins other than arabinogalactan protein).
[0072] Therefore, the term "glycoprotein content of gum arabic for use according to the present invention" (i.e. the content of glycoproteins in gum arabic for use according to the present invention) as used in the context of the present invention refers to the total content of all glycoproteins present in gum arabic for use according to the present invention.
[0073] The glycoprotein content of gum arabic as used according to the invention also refers to the individual glycoprotein molecules as a whole or as such (ie not only to their pure content of proteins or protein groups).
[0074] The glycoprotein content of the gum arabic used in the present invention can be determined by conventional analytical or assay methods known or familiar to those skilled in the art, in particular by chromatography, preferably by HPLC chromatography or SEC, in particular SEC-MALLS method (size exclusion chromatography combined with multi-angle laser light scattering). This is well known to those skilled in the art. In this regard, reference can be made to relevant technical literature and professional publications, in particular to "Acacia senegal vs. Acacia seyal gums-Part 1: Composition and structure of hyperbranched plant exudates" (Food Hydrocolloids, Vol. 51, October 2015, pp. 41 to 53) by L. Lopez-Torrez et al. (also see URL or link: https: / / doi.org / 10.1016 / j.foodhyd.2015.04.019), and the literature cited therein (in particular, see L. Picton et al. "Analysis of a complex polysaccharide (gumarabic) by multi-angle laser light scattering coupled on-line to size exclusion chromatography and flow field flow fractionation" (Carbohydrate Polymers, Vol. 42, No. 1, May 2000, pp. 23 to 31; see also URL or link: https: / / doi.org / 10.1016 / S0144-8617(99)00139-3), the above-mentioned documents related to the determination of glycoprotein content and all the disclosed contents thereof are incorporated herein by reference in their entirety.
[0075] For the sake of ease of understanding and clarity, it is also pointed out that the characteristic parameter for the glycoprotein content used according to the invention should be distinguished from the parameter for the protein content (wherein, in particular in the food sector, the protein content is determined by determining the total nitrogen content and then converting it by a nitrogen conversion factor [usually 6.25 or 6.38], whereby this protein content is usually significantly lower than the parameter for the glycoprotein content used according to the invention, since only a small and sometimes only a relatively small proportion of the glycoprotein molecules is formed from protein groups, while the remaining and usually predominant proportion of the molecules is formed from carbohydrate or sugar residues or groups). The determination of protein content is also based on an independent determination method: For more details on protein content determination, please refer to: DIN EN ISO 8968-2, June 2002 edition, and the Official Collection of Methods (ASU) for Sampling and Testing Food, Consumer Products, Cosmetics, Tobacco Products and Animal Feed: BVL L01.00-10 / 2:2016-03, Food Analysis - Determination of Nitrogen Content in Milk - Part 2: Block Digestion Method (Macroscopic Method) (adopting the German standard of the same name DIN EN ISO 8968-2, June 2002 edition); see also the "IDF Fact Sheet on Protein Determination" (German Dairy Association - VDM), May 2013 edition.
[0076] Generally speaking, the weight average molecular weight of the glycoprotein present in the gum arabic used in the present invention is In 10 4 g / mol to 10 7 g / mol range, especially in the 1x 10 5 g / mol to 9x 10 6 g / mol range, preferably 1.5 x 10 5 g / mol to 6x10 6 This enables particularly excellent properties (especially application properties) of the composition of the present invention as well as a higher MCT loading to be achieved.
[0077] In general, according to the invention, it can be provided that the glycoprotein content of the gum arabic is provided at least in part (in particular predominantly) by and / or is formed by arabinogalactan protein (synonymically also referred to as "AGP"). In this way, particularly excellent properties (in particular application properties) of the composition according to the invention can be achieved, as well as a high MCT loading.
[0078] According to the invention, it is particularly preferred that at least 50%, in particular at least 60%, preferably at least 65%, of the glycoprotein content of the gum arabic, calculated as glycoprotein content, is provided by and / or formed by arabinogalactan protein.
[0079] Furthermore, according to the present invention, it is particularly preferred that 50% to 99%, in particular 60% to 98%, preferably 65% to 95%, of the glycoprotein content of the gum arabic, calculated as glycoprotein content, is provided and / or formed by arabinogalactan protein (also synonymously referred to as "AGP").
[0080] Medium chain triglycerides (MCT) generally refer to triglycerides containing medium chain fatty acids. Medium chain fatty acids include saturated fatty acids such as caproic acid, caprylic acid, capric acid and lauric acid. The above acids are saturated straight chain or unbranched C6, C8, C 10 or C 12 Carboxylic acids. Medium-chain triglycerides can be obtained on an industrial scale, for example, by hydrolyzing vegetable fats (e.g., coconut fat and palm kernel oil), fractionating the medium-chain fatty acids, and then esterifying with glycerol. The medium-chain triglycerides (MCTs) used according to the present invention are typically at least substantially colorless, odorless, and tasteless.
[0081] For more information on medium-chain triglycerides (MKT or MCT), see Chemie Lexikon (10th edition, volume 4), Georg Thieme Verlag (Stuttgart / New York, 1998, page 1560, keyword "MCT (MKT)") and in each case the literature cited therein.
[0082] The compositions of the present invention are described in further detail below with reference to further embodiments and implementations of the present invention:
[0083] As mentioned above, a special gum arabic with a high glycoprotein content is used in the context of the present invention. As mentioned above, this enables a very high loading of the underlying polysaccharide-based carrier material with medium chain triglycerides (MCT).
[0084] In the context of the present invention, regarding the glycoprotein content, specifically as follows:
[0085] The glycoprotein content of gum arabic is at least 4.5 wt.%, particularly at least 5 wt.%, preferably at least 5.5 wt.%, more preferably at least 6 wt.%, calculated on the basis of gum arabic.
[0086] - Furthermore, the glycoprotein content of gum arabic is at most 25 wt.% based on gum arabic.
[0087] Furthermore, the glycoprotein content of gum arabic is at most 22 wt.%, in particular at most 20 wt.%, preferably at most 18 wt.%, more preferably at most 16 wt.%, based on gum arabic.
[0088] According to the invention, it can be provided in particular that the glycoprotein content of gum arabic is in the range of 4.5 wt.% to 22 wt.%, in particular in the range of 5 wt.% to 20 wt.%, preferably in the range of 5.5 wt.% to 18 wt.%, more preferably in the range of 6 wt.% to 16 wt.%, calculated on the basis of gum arabic.
[0089] As mentioned above, according to the present invention, particularly high loadings of compositions or particles having an underlying polysaccharide-based carrier material can be achieved, in particular due to the high glycoprotein content.
[0090] As stated for the composition of the present invention, the triglyceride content of the present invention refers in the present case to the content of at least one medium chain triglyceride, in particular at least one linear saturated C6, C8, C 10 or C 12 The content of at least one triglyceride of a carboxylic acid.
[0091] In this regard, according to the present invention, the following are specific examples:
[0092] - Thus, the triglyceride content of the composition or granule may be at least 55 wt.%, in particular at least 57.5 wt.%, preferably at least 60 wt.%, preferably at least 65 wt.%, based on the composition or granule.
[0093] - In particular, the triglyceride content of the composition or granule may be up to 90 wt.%, based on the composition or granule.
[0094] Furthermore, the triglyceride content of the composition or granule according to the invention may be at most 87.5 wt.%, in particular at most 85 wt.%, preferably at most 82.5 wt.%, preferably at most 80 wt.%, based on the composition or granule.
[0095] In particular, it can be provided according to the invention that the triglyceride content of the composition or granules is in the range of 55 wt.% to 87.5 wt.%, in particular in the range of 57.5 wt.% to 85 wt.%, preferably in the range of 60 wt.% to 82.5 wt.%, preferably in the range of 65 wt.% to 80 wt.%, based on the composition or granules.
[0096] Furthermore, the composition of the invention or the granules thereof may have the following content of gum arabic:
[0097] - According to the invention it can be provided that the composition or granules have a gum arabic content of at most 50 wt.%, preferably in the range of 10 to 50 wt.%, based on the composition or granules.
[0098] Furthermore, it can also be provided within the context of the present invention that the composition or granules have a gum arabic content of at most 45 wt.%, in particular at most 42.5 wt.%, preferably at most 40 wt.%, preferably at most 35 wt.%, based on the composition or granules.
[0099] In particular, it can be provided according to the present invention that the gum arabic content of the composition or granules is in the range of 12.5 wt.% to 45 wt.%, in particular in the range of 15 wt.% to 42.5 wt.%, preferably in the range of 17.5 wt.% to 40 wt.%, preferably in the range of 20 wt.% to 35 wt.%, based on the composition or granules.
[0100] In addition, the following combination of the content or amount of each ingredient or component in the composition of the present invention is also important. Specifically, the composition of the present invention may also have the following content or amount of medium chain triglycerides (MCT), and increased glycoprotein content of gum arabic:
[0101] Therefore, according to the present invention, it can be provided that
[0102] - the glycoprotein content of gum arabic is at least 4.5 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at least 55 wt.%, calculated as the composition or granule; or
[0103] - the glycoprotein content of gum arabic is at least 5 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at least 57.5 wt.%, calculated as the composition or granule; or
[0104] - the glycoprotein content of gum arabic is at least 5.5 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at least 60 wt.%, calculated as the composition or granule; or
[0105] The glycoprotein content of gum arabic is at least 6 wt.% based on gum arabic, and the triglyceride content of the composition or granule is at least 65 wt.% based on the composition or granule.
[0106] Furthermore, according to the present invention, it can be provided that
[0107] - the glycoprotein content of gum arabic is at most 25 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at most 90 wt.%, calculated as the composition or granule; or
[0108] - the glycoprotein content of gum arabic is at most 22 wt.%, calculated as gum arabic, and wherein the triglyceride content of the composition or granule is at most 87.5 wt.%, calculated as the composition or granule; or
[0109] - the glycoprotein content of gum arabic is at most 20 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at most 85 wt.%, calculated as the composition or granule; or
[0110] - the glycoprotein content of gum arabic is at most 18 wt.%, calculated as gum arabic, and the triglyceride content of the composition or granule is at most 82.5 wt.%, calculated as the composition or granule; or
[0111] - the glycoprotein content of gum arabic is at most 16 wt.%, calculated on the basis of gum arabic, and wherein the triglyceride content of the composition or granule is at most 80 wt.%, calculated on the basis of the composition or granule.
[0112] Furthermore, within the scope of the present invention, it may also be provided that:
[0113] - the glycoprotein content of gum arabic is in the range of 4 wt.% to 25 wt.% based on gum arabic, and the triglyceride content of the composition or granule is in the range of 50 wt.% to 90 wt.% based on the composition or granule; or
[0114] - the glycoprotein content of gum arabic is in the range of 4.5 wt.% to 22 wt.% based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 55 wt.% to 87.5 wt.% based on the composition or granule; or
[0115] - the glycoprotein content of gum arabic is in the range of 5 wt.% to 20 wt.% based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 57.5 wt.% to 85 wt.% based on the composition or granule; or
[0116] - the glycoprotein content of gum arabic is in the range of 5.5 wt.% to 18 wt.% based on gum arabic, and the triglyceride content of the composition or granule is in the range of 60 wt.% to 82.5 wt.% based on the composition or granule; or
[0117] - The glycoprotein content of gum arabic is in the range of 6 wt.% to 16 wt.% based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 65 wt.% to 80 wt.% based on the composition or granule.
[0118] With regard to the gum arabic used in a preferred manner according to the invention, the following points should also be mentioned:
[0119] In particular, gum arabic may be natural based and / or of natural origin, in particular of plant-based origin.
[0120] Furthermore, gum arabic may be based on or obtained from a plant exudate, in particular based on or obtained from a plant exudate of the acacia tree, in particular the acacia tree (Acacia senegal, or synonymously Acacia senegal).
[0121] According to the invention, it can be provided in particular that gum arabic is obtained from or originates from an acacia tree, in particular the gum arabic tree (Acacia senegalensis or, equivalently, Acacia senegalensis). According to the invention, it can also be provided that gum arabic is obtained from or is based on an exudate of an acacia tree, in particular the gum arabic tree (Acacia senegalensis or, equivalently, Acacia senegalensis).
[0122] In this context, the Applicant has also surprisingly found that a specific gum arabic based on the aforementioned gum arabic tree (Acacia senegal, or synonymously Acacia senegal) is particularly suitable for use in or as a polysaccharide-based carrier material, especially considering that the specific gum arabic in question has a high glycoprotein content.
[0123] According to one embodiment of the present invention, it can be provided in particular that the glycoprotein content of the gum arabic can be controlled and / or adjusted by selecting the gum arabic, in particular by selecting the (plant) material or (plant) species from which the gum arabic is obtained, preferably based on exudates, optionally with additional enrichment, in particular by fractionation. In this case, the (plant) material or (plant) species can in particular be selected from the group of acacia trees, in particular the gum arabic tree (Acacia senegal or, equivalently, Acacia senegal).
[0124] According to a further embodiment of the invention, it can also be provided that the glycoprotein content of the gum arabic typically used according to the invention is controlled and / or adjusted by enrichment, in particular using fractionation.
[0125] Adjustments to the glycoprotein content can also be made cumulatively or in addition to the specific selection of gum arabic mentioned above.
[0126] The gum arabic used in the present invention is also characterized in that the gum arabic contains as its main component at least one polysaccharide, preferably at least one polysaccharide including an acidic alkali metal and / or alkaline earth metal salt of (poly)arabic acid, particularly preferably at least one preferably branched polysaccharide of L-arabinose, D-galactose, L-rhamnose and D-glucuronic acid, and the (molar ratio of L-arabinose, D-galactose, L-rhamnose and D-glucuronic acid is particularly in the range of The ratios of the above ingredients are 2.5-4.5:0.5-5:0.1-2:0.5-2.5, preferably in the range of 2.7-4:1-4:0.5-1.5:0.7-2, preferably in the range of 2.9-3.7:1.5-3.5:0.8-1.2:1-1.7, particularly preferably about 3.5:about 2.9:about 1.1:about 1.6, more preferably 3.5:2.9:1.1:1.6, or more preferably 3:3:1:1.
[0127] Therefore, according to the present invention, gum arabic is particularly used with a defined polysaccharide content and a specific composition or composition. This further improves its performance compared to medium-chain triglycerides (MCTs), particularly with regard to the immobilization or application of MCTs. Specifically, polysaccharides are also responsible for the specific properties of the composition of the present invention or particles based on polysaccharide-based carrier materials when dispersed or when forming an emulsion by introducing the composition into a liquid, particularly water.
[0128] Furthermore, the polysaccharide content is also important: for example, the present invention may provide that the polysaccharide content of gum arabic is in the range of 75% to 96% by weight, based on gum arabic. In particular, the polysaccharide content of gum arabic is at least 75% by weight, based on gum arabic. Furthermore, the polysaccharide content of gum arabic is at most 96% by weight, based on gum arabic.
[0129] In particular, the present invention may also provide the following:
[0130] - Therefore, the polysaccharide content of gum arabic may be in the range of 78 wt.% to 95.5 wt.%, particularly in the range of 80 wt.% to 95 wt.%, preferably in the range of 82 wt.% to 94.5 wt.%, preferably in the range of 84 wt.% to 94 wt.%, calculated as gum arabic.
[0131] Furthermore, the polysaccharide content of gum arabic may be at least 78 wt.%, in particular at least 80 wt.%, preferably at least 82 wt.%, preferably at least 84 wt.%, calculated on the basis of gum arabic.
[0132] - Further, the polysaccharide content of gum arabic may be at most 95.5 wt.%, in particular at most 95 wt.%, preferably at most 94.5 wt.%, preferably at most 94 wt.%, calculated as gum arabic.
[0133] Regarding the medium chain triglycerides (MCT) used in the present invention, the following can be provided in particular according to the present invention:
[0134] In particular, the medium chain triglyceride (MCT) can be a triglyceride of a C8 carboxylic acid, in particular a linear saturated C8 carboxylic acid. In this case, it can be provided that the medium chain triglyceride (MCT) is tricaprylin.
[0135] In addition, medium chain triglycerides (MCT) can be C8 carboxylic acids and C 10 Mixed triglycerides of carboxylic acids, especially straight chain saturated C8 and C 10 In this regard, the C8:C of medium chain triglycerides (MCT) 10 The ratio may be in the range of 30%-90%:70%-10%, particularly in the range of 50%-80%:50%-20%, preferably in the range of 55%-75%:45%-25%.
[0136] The above-mentioned medium-chain triglycerides (MCT) result in particularly good application and handling properties, also in relation to products or preparations in the cosmetic, pharmaceutical or food sectors.
[0137] In the present invention, due to the high load of MCT, a composition with a high ketone body index can be provided. The ketone body index can also be used as a measure of the load or preparation of a composition according to the present invention on medium chain triglycerides (MCT).
[0138] The values given below relate specifically to conditions or situations in which, during physiological metabolism in the human body, a total of 6 ketone body molecules (calculated in this case as 3-hydroxybutyrate (3-BHB)) are formed per medium-chain triglyceride molecule.
[0139] In this context, the physiological condition is the oxidation of medium-chain triglycerides, particularly in the liver, thereby releasing ketone bodies (ketone bodies), but there is no desire to rely on or be limited thereto. The ketone body index is also based on the excellent nutritional properties of the composition of the present invention. In addition, a higher ketone body index is also associated with excellent handling and application properties of cosmetic or pharmaceutical products using the composition of the present invention.
[0140] In this context, the following also particularly apply to the ketone index:
[0141] According to the invention, the composition according to the invention may have a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyric acid (3-BHB) per gram of composition, which is at least 0.5 mmol / g.
[0142] - In particular, the composition may have a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of composition, of at least 1 mmol / g, in particular at least 2 mmol / g, preferably at least 3 mmol / g, more preferably at least 4 mmol / g.
[0143] According to the invention, the composition according to the invention may have a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyric acid (3-BHB) per gram of composition, ranging from 0.5 mmol / g to 50 mmol / g.
[0144] - In particular, the composition may have a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of composition, in the range of 1 mmol / g to 45 mmol / g, in particular in the range of 2 mmol / g to 40 mmol / g, preferably in the range of 3 mmol / g to 30 mmol / g, more preferably in the range of 4 mmol / g to 25 mmol / g.
[0145] According to the present invention, the ketone body index of the composition according to the present invention can generally have a high value. Specifically, the composition according to the present invention also has a high density or high loading of medium-chain triglycerides (MCTs). On this basis, corresponding products or articles containing the composition according to the present invention can also have a high ketone body index. This has advantages in the cosmetic or pharmaceutical fields (particularly with respect to the processing and application properties of the composition according to the present invention) as well as in the food field (particularly with respect to the nutritional properties of the composition according to the present invention).
[0146] For the composition according to the invention, in particular the following combinations of values for the ketone body index, the glycoprotein content of gum arabic and the triglyceride content can be set or predetermined:
[0147] Therefore, according to the present invention, it is possible to provide:
[0148] - the composition comprises a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 0.5 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 4 wt.%, and wherein the triglyceride content of the composition or granule, calculated as the composition or granule, is at least 50 wt.%; or
[0149] - the composition comprises a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 1 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 4.5 wt.%, and wherein the triglyceride content of the composition or granule, calculated as the composition or granule, is at least 55 wt.%; or
[0150] - the composition comprises a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 2 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 5 wt.%, and wherein the triglyceride content of the composition or granule, calculated as the composition or granule, is at least 57.5 wt.%; or
[0151] - the composition comprises a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 3 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 5.5 wt.%, and wherein the triglyceride content of the composition or granule, calculated as the composition or granule, is at least 60 wt.%; or
[0152] -The composition comprises a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 4 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 6 wt.%, and wherein the triglyceride content of the composition or granule, calculated as the composition or granule, is at least 65 wt.%.
[0153] Furthermore, the present invention may also provide:
[0154] - the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 0.5 mmol / g to 50 mmol / g, and wherein the glycoprotein content of gum arabic is in the range of 4 wt.% to 25 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 50 wt.% to 90 wt.%, based on the composition or granule; or
[0155] - the composition has a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, ranging from 1 mmol / g to 45 mmol / g, and wherein the glycoprotein content of gum arabic is in the range of 4.5 wt.% to 22 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 55 wt.% to 87.5 wt.%, based on the composition or granule; or
[0156] - the composition has a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, ranging from 2 mmol / g to 40 mmol / g, and wherein the glycoprotein content of gum arabic is in the range of 5 wt.% to 20 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 57.5 wt.% to 85 wt.%, based on the composition or granule; or
[0157] - the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 3 mmol / g to 30 mmol / g, and wherein the glycoprotein content of gum arabic is in the range of 5.5 wt.% to 18 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 60 wt.% to 82.5 wt.%, based on the composition or granule; or
[0158] -The composition has a ketone body index (ketogenic index), which is calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, which ranges from 4 mmol / g to 25 mmol / g, and wherein the glycoprotein content of gum arabic is in the range of 6 wt.% to 16 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 65 wt.% to 80 wt.%, based on the composition or granule.
[0159] Furthermore, it can be provided according to the invention that the composition according to the invention comprises at least one emulsifier.
[0160] The use of an emulsifier has the following advantages: on the one hand, it further improves the fixation or coating of the composition particles with medium-chain triglycerides. On the other hand, the dispersibility or emulsification properties of the composition according to the invention are further improved, especially when introduced into a liquid (e.g., water). In particular, this allows for the production of particularly homogeneous emulsions with stably bound medium-chain triglycerides (MCTs).
[0161] In this context, it can be provided in particular that the composition has an emulsifier content of at least 0.0001 wt.%, in particular at least 0.001 wt.%, preferably at least 0.01 wt.%, based on the composition. Furthermore, according to the invention, it can be provided that the composition has an emulsifier content of at most 5 wt.%, in particular at most 2.5 wt.%, preferably at most 1 wt.%, based on the composition. Furthermore, according to the invention, it can also be provided that the composition has an emulsifier content in the range of 0.0001 wt.% to 5 wt.%, in particular in the range of 0.001 wt.% to 2.5 wt.%, preferably in the range of 0.01 wt.% to 1 wt.%, based on the composition.
[0162] The above-mentioned amounts of optional emulsifiers are naturally only relevant for the composition of the present invention itself. However, it goes without saying that products based thereon (i.e. other products containing the composition of the present invention (e.g., foods, cosmetics, and pharmaceutical products, etc.)) may also contain other emulsifiers or emulsifier components (e.g., surfactants, etc.), so that in these other products containing the composition of the present invention (e.g., shampoos, shower gels, etc.), significantly higher total amounts of emulsifiers may be used (e.g., 7 wt.% to 20 wt.% in these other products).
[0163] According to the present invention, the emulsifier may be an amphoteric emulsifier, an anionic emulsifier, a cationic emulsifier or a nonionic emulsifier.
[0164] In the context of the present invention, it can be provided in particular that the emulsifier is selected from the group of fatty acid glycerides, in particular fatty acid mono- and diglycerides, and salts thereof; citric acid esters of fatty acid glycerides, in particular citric acid esters of fatty acid mono- and diglycerides, and salts thereof; tartaric acid esters and monoacetyltartaric acid esters and diacetyltartaric acid esters of fatty acid glycerides, in particular tartaric acid esters and diacetyltartaric acid esters of fatty acid glycerides, and salts thereof; acetate esters of fatty acid glycerides, in particular acetate esters of fatty acid mono- and diglycerides, and salts thereof; lactic acid esters of fatty acid glycerides. , especially lactic acid esters of mono- and diglycerides of fatty acids, and salts thereof; mixed acetates and tartarics of glycerides of fatty acids, especially mixed acetates and tartarics of mono- and diglycerides of fatty acids, and salts thereof; polyglycerol fatty acid esters, especially polyglycerol mono-, di- and poly-fatty acid esters, preferably polyglycerol polyricinoleate; sorbitan esters of fatty acids, especially polyoxyethylene sorbitan esters, preferably polyoxyethylene sorbitan monoesters, especially polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan tristearate; ethoxylated fatty alcohols; ethoxylated fatty acid glycerides, in particular ethoxylated mono- and diglycerides of fatty acids, and their salts; alkyl polyglucosides and sugar glycerides, in particular cetearyl glucoside; sugar esters of fatty acids, in particular sucrose esters of fatty acids; modified starch; modified cellulose; quaternary ammonium compounds (esterquats); lecithins; phospholipids; alkyl glucose sesquistearate, in particular methyl glucose sesquistearate; fatty alcohols; fatty acids and their salts and esters; silicones and silicones; polydimethylsiloxanes Alkane and modified polydimethylsiloxanes, in particular PEG / PPG polydimethylsiloxanes; alkali metal alkyl sarcosinates, in particular sodium alkyl sarcosinates, preferably alkali metal lauryl sarcosinates; amino acid acyl esters and salts thereof; POE / PPG copolymers; phosphate esters and salts thereof, in particular cetyl phosphates, preferably alkali metal cetyl phosphates, preferably potassium cetyl phosphate; polyacrylates; castor oil and modified castor oil, in particular PEG castor oil and PEG castor oil fatty acid esters and difatty acid esters; ethoxylated alkyl sulfates and alkyl ether sulfates; and alkyl ether sulfates; and combinations and mixtures thereof.
[0165] In particular, it can be provided according to the invention that the emulsifier is bound and / or immobilized on the particles of the composition; and / or that the composition comprises the emulsifier in a form bound and / or immobilized on the particles.
[0166] However, it can also be provided according to the invention that the emulsifier can be in particulate form and / or in the form of emulsifier particles. In particular, the composition can comprise the emulsifier in separate form, in particular unbound and / or free emulsifier particles.
[0167] The composition according to the invention is also characterized by the following properties:
[0168] For example, the composition can preferably be designed to be free-flowing or flowable. This results in particularly good processing properties. In particular, this allows for easy incorporation of the composition into liquids (such as water). This also improves the dosing characteristics. This also facilitates better uniform incorporation into powdered compositions.
[0169] Furthermore, the present invention can provide that the compositions of the invention are at least substantially free of lumps or large agglomerates. This also improves the performance during dispersion or emulsion formation. In particular, no lumps or similar phenomena occur in the resulting dispersion or emulsion. This also facilitates better uniform incorporation into the composition in powder form.
[0170] Furthermore, the present invention can particularly provide that the composition according to the invention is at least substantially free of particle agglomerations or clusters, in particular, free of macroagglomerates of particles having a size greater than 5 mm, in particular greater than 4.5 mm, preferably greater than 4 mm, and particularly preferably greater than 3.5 mm. In particular, in this context, the particles of the composition according to the invention are configured such that they at least substantially do not aggregate to form such particle agglomerates or clusters, in particular macroagglomerates. This improves flowability and pourability and enhances the formation of dispersions or emulsions. Furthermore, this facilitates better uniform incorporation into the composition in powder form.
[0171] The compositions of the present invention are further characterized by a defined residual moisture content. This defined residual moisture content is particularly associated with a further improvement in the pourability or flowability of the composition. Furthermore, a defined or low residual moisture content also prevents the formation of lumps during storage of the compositions of the present invention, thereby providing the compositions of the present invention with a higher (storage) stability. Furthermore, due to the defined residual moisture content, the compositions of the present invention also have an improved emulsifying capacity.
[0172] Thus, it can be provided in particular that the composition according to the invention has a residual moisture content of at most 5 wt.%, in particular at most 4 wt.%, preferably at most 3 wt.%, based on the composition.
[0173] Furthermore, the composition has a residual moisture content of at least 0.1 wt.%, in particular at least 0.25 wt.%, preferably at least 0.5 wt.%, based on the composition.
[0174] Furthermore, the residual moisture content of the composition is in the range of 0.1 wt.% to 5 wt.%, particularly in the range of 0.25 wt.% to 4 wt.%, preferably in the range of 0.5 wt.% to 3 wt.%, based on the composition.
[0175] The composition according to the invention is also characterized by defined particle characteristics:
[0176] Thus, according to the present invention, it can be provided that the particles of the composition have a D90 particle size, in particular a D90 particle diameter, in the range of 0.01 mm to 5 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.2 mm to 0.8 mm; this is in particular determined by light diffraction, preferably by laser diffraction according to ISO 13320:2020. The determination methods in this regard are known per se to the skilled person and therefore require no further explanation.
[0177] Furthermore, the particles of the composition may have a D50 particle size, in particular a D50 particle diameter, in the range of 0.01 mm to 3 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.15 mm to 0.75 mm; this is in particular determined by light diffraction, preferably by laser diffraction according to ISO 13320:2020. The determination methods in this regard are known per se to the skilled person and therefore require no further explanation.
[0178] According to one embodiment of the invention, it can in particular be provided that the composition according to the invention is at least substantially free of further and / or additional carrier materials, in particular at least substantially free of further and / or additional carrier materials for medium-chain triglycerides (MCT).
[0179] In particular, it can be provided according to the invention that the composition comprises at least substantially no further and / or additional carrier materials, in particular at least substantially no further and / or additional carrier materials for medium-chain triglycerides (MCT).
[0180] Preferably, the composition is at least substantially free of further and / or additional polysaccharide-based carrier materials. According to the invention, it may be provided that the composition comprises at least substantially no further and / or additional polysaccharide-based carrier materials.
[0181] In particular, it can be provided according to the invention that the composition of the invention is at least substantially free of other and / or additional polysaccharide-based carrier materials based on maltodextrin and / or starch, in particular modified starch.
[0182] In particular, it can be provided that the composition is at least substantially free of further and / or additional polysaccharide-based carrier materials based on maltodextrin and / or starch, in particular modified starch.
[0183] In this respect, it can in particular be provided that the composition according to the invention is at least substantially free from further and / or additional polysaccharide-based carrier materials comprising or consisting of maltodextrin and / or modified starch, or at least substantially free from such carrier materials.
[0184] Furthermore, the composition may be at least substantially free of carrier materials other than gum arabic, in particular at least substantially free of polysaccharide-based carrier materials other than gum arabic, preferably at least substantially free of gum arabic other than gum arabic.
[0185] In particular, it can be provided according to the invention that the composition comprises at least substantially no carrier material other than gum arabic, in particular at least substantially no polysaccharide-based carrier material other than gum arabic, preferably at least substantially no gum arabic other than gum arabic.
[0186] According to the invention, it can in particular be provided that the composition according to the invention does not comprise any other polysaccharide-based carrier material besides gum arabic.
[0187] According to the invention, it can in particular also be provided that the composition according to the invention comprises no further and / or other proteins besides glycoproteins, in particular no phosphoproteins, preferably no caseins.
[0188] Furthermore, according to the present invention, it can in particular be provided that the composition according to the invention does not contain any phosphoproteins, preferably does not contain caseins.
[0189] On this basis, the compositions of the present invention exhibit extremely uniform properties in terms of loading or fixation of medium-chain triglycerides (MCTs), including high loadings, as well as in terms of the dispersibility or emulsification of the compositions of the present invention. In particular, the disadvantages associated with other carrier materials are overcome, while the compositions of the present invention also exhibit a high loading of medium-chain triglycerides (MCTs). Furthermore, the compositions of the present invention exhibit high compatibility and good compatibility.
[0190] According to this aspect, the present invention also relates to a composition according to the invention, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular for use in a cosmetic, pharmaceutical or food product, preferably a composition as defined above, wherein said composition is obtainable or obtained according to a process according to the invention as defined below.
[0191] The present invention, according to its first aspect and according to its further aspects as described below, therefore has a number of advantages and special features which make the composition according to the invention unique and special, and in particular highly effective.
[0192] For further details of this aspect of the invention, reference may also be made to the following explanations of other aspects of the invention, which are also applicable to this aspect of the invention.
[0193] According to the second aspect of the present invention, another object of the present invention is also a food, cosmetic or pharmaceutical product comprising the composition of the present invention as described above.
[0194] In this context, the compositions of the present invention can be used to provide corresponding products or preparations having a similarly high content of medium-chain triglycerides in the form of a stable dispersion or emulsion. The products of the present invention have excellent handling and application properties. Furthermore, foods containing the compositions of the present invention have excellent organoleptic properties and very good nutritional properties.
[0195] According to a third aspect of the present invention, another object of the present invention is the use of the composition of the present invention as defined above in a food, cosmetic or pharmaceutical product, or the use of the composition of the present invention as defined above for the preparation of a food, cosmetic or pharmaceutical product.
[0196] Regarding the above-mentioned objects according to the second and third aspects of the present invention, they can in this respect in particular be manifested in this way:
[0197] Therefore, according to the present invention, it can be provided that
[0198] - the food, cosmetic or pharmaceutical product comprises the composition in an amount of at least 0.5 wt.%, in particular at least 1 wt.%, preferably at least 3 wt.%, preferably at least 5 wt.%, relative to the product; or
[0199] - the food, cosmetic or pharmaceutical product comprises the composition in an amount of at most 90 wt.%, in particular at most 80 wt.%, preferably at most 70 wt.%, preferably at most 60 wt.%, based on the product; or
[0200] - the food, cosmetic or pharmaceutical product comprises the composition in an amount ranging from 0.5 wt.% to 90 wt.%, in particular in the range of 1 wt.% to 80 wt.%, preferably in the range of 3 wt.% to 70 wt.%, preferably in the range of 5 wt.% to 60 wt.%, based on the product.
[0201] In general, it can also be provided according to the present invention that the food, cosmetic or pharmaceutical product comprises the composition and at least one carrier (excipient), in particular a physiologically compatible carrier (excipient). In this way, the product can be further customized or specially designed while ensuring a high level of compatibility.
[0202] Furthermore, the products according to the second and third aspects of the present invention are characterized by the following properties or structures:
[0203] Thus, the food, cosmetic or pharmaceutical product, in particular the food product, may be a functional food, a novel food, a food additive, a food supplement, a therapeutic food and / or a dietary food, an energy snack, an appetite suppressant or a strength and / or endurance sports supplement.
[0204] Furthermore, the food, cosmetic or pharmaceutical product, in particular a cosmetic, may be a personal care and / or body cleansing product, in particular a skin and / or hair care and / or hair cleansing product, a skin and / or hair care and / or hair cleansing product, a skin and / or hair cleansing product, a skin and / or hair cleansing product, a skin and / or hair cleansing product, or a hair cleansing product. Skin and / or hair cleansing products, preferably shower gels, shampoos, bath additives, soaps, skin creams, lotions, gels, creams, sunscreens, insect repellents, facial masks, shaving foams or soaps, self-tanning products, hair removal products, baby care products, beard care products, wet wipes, intimate hygiene products, etc.; tooth and / or oral care products or tooth and / or oral cleansing products, preferably cosmetics. Tooth and / or oral care products or oral cleaning products, preferably toothpaste, mouthwash, adhesive compositions for tooth replacement products, etc.; hair treatment products, preferably hair coloring products, hair styling products, hair conditioners, etc.; products for application for visual and / or decorative purposes, preferably make-up, lip care products (such as lipstick or lip gloss), eye care products (such as mascara or eye shadow), facial make-up or rouge, nail polish, etc.; hair treatment products, preferably hair coloring products, hair styling products, hair conditioners, etc.; products for application for visual and / or decorative purposes, preferably make-up, lip care products (such as lipstick or lip gloss), eye care products (such as mascara or eye shadow), facial make-up, or products to improve body odor or fragrance products, preferably deodorants, perfumes, light perfumes, etc.
[0205] According to the present invention, it can also be provided that the food, cosmetic or pharmaceutical product is a liquid, ointment, cream, paste, lotion, gel, spray or solid, powder, tablet, pill, capsule, coated tablet or the like, and / or is formulated and / or designed as a liquid, ointment, cream, paste, lotion, gel, spray, solid, powder, tablet, pill, capsule, coated tablet or the like.
[0206] According to one embodiment of the present invention, the food, cosmetic, or pharmaceutical product may be in the form of a dry formulation, in particular a powdered dry formulation. According to the present invention, this is specifically designed so that, preferably during application and / or use, in particular at the user and / or consumer end, the dry formulation is introduced and / or stored and / or added to a liquid, in particular water. In this way, a ready-to-use (final) product may be provided, in particular by the user or consumer themselves, and a stable dispersion, in particular an emulsion, may be obtained.
[0207] For further details of the second or third aspect of the present invention described herein, reference may also be made to the explanations of other aspects of the present invention, which are also applicable to the present aspect of the present invention.
[0208] Similarly, according to a fourth aspect of the present invention, an object of the present invention is a process according to the invention for preparing a composition, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), the process being in particular a process for preparing a composition as defined above,
[0209] The method comprises the following method steps, in particular in the order of the method steps given below:
[0210] (i) providing and / or preparing a preferably aqueous homogeneous dispersion, in particular a preferably aqueous homogeneous emulsion, comprising gum arabic as a polysaccharide-based carrier material and at least one medium-chain triglyceride (MCT), in a preferably aqueous liquid carrier medium, the at least one medium-chain triglyceride, in particular at least one linear saturated C6, C8, C 10 or C 12 at least one triglyceride of a carboxylic acid,
[0211] wherein gum arabic is used, having a glycoprotein content of at least 4 wt.% and preferably in the range of 4 to 20 wt.%, calculated on the basis of the gum arabic, and wherein the amount of triglycerides used is at least 50 wt.% and preferably in the range of 50 to 90 wt.%, based on the dry weight of the dispersion, in particular the emulsion; hereinafter
[0212] (ii) drying, in particular spray drying, the dispersion (in particular emulsion) obtained in process step (i), wherein the preferably aqueous liquid carrier medium is at least substantially completely removed, thereby obtaining a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular a composition as described above.
[0213] In the context of the process according to the invention, method step (i) can be carried out by introducing shear energy and / or shear forces. Specifically, in method step (i), homogenization, in particular homogenization of the ingredients, can be carried out by introducing shear energy and / or shear forces, in particular, wherein the introduction of shear energy and / or shear forces is carried out by high-pressure homogenization and / or preferably by a high-pressure homogenizer. In particular, high-pressure homogenization can be carried out in method step (i), in particular by a high-pressure homogenizer.
[0214] In this context, it can be provided according to the invention that the high-pressure homogenization can be carried out at a pressure gradient of up to 2500 bar, in particular up to 2250 bar, preferably up to 2000 bar. In particular, the high-pressure homogenization can be carried out at a pressure gradient in the range of 50 bar to 2500 bar, in particular in the range of 75 bar to 2250 bar, preferably in the range of 100 bar to 2000 bar.
[0215] For example, high pressure homogenizers based on piston / gap or piston / nozzle homogenizers may be used.
[0216] In particular, within the scope of the present invention, continuous process control with high throughput can be achieved. In particular, the composition according to the invention can be produced continuously.
[0217] According to one embodiment of the present invention, it can also be provided that in method step (i), a two-stage and / or multi-stage method is carried out, in particular, wherein in method step (i), first mixing of the components, in particular stirring, is achieved, in particular to obtain a (pre)dispersion, in particular a (pre)emulsion, preferably by introducing mixing and / or stirring energy and / or stirring forces, followed by homogenization, in particular homogenization of the components, by introducing shear energy and / or shear forces, preferably high-pressure homogenization of the (pre)dispersion, in particular a (pre)emulsion, in particular as described above, in particular to obtain a preferably aqueous homogeneous dispersion of the components, in particular a preferably aqueous homogeneous emulsion.
[0218] Based on the process control according to the invention, in method step (i), a finely divided homogeneous dispersion, in particular a finely divided homogeneous emulsion, is produced and / or provided. This is also advantageous for subsequent drying, in particular spray drying (see method step (ii)). In particular, on this basis, compositions according to the invention can also be provided with defined particle properties or sizes.
[0219] Typically, in process step (i), the homogeneous dispersion (in particular the homogeneous emulsion) can be adjusted to a viscosity (in particular the apparent viscosity) of at most 2500 mPa-s, in particular at most 1000 mPa-s, preferably at most 400 mPa-s, or to have a viscosity (in particular the apparent viscosity) in accordance with DIN EN ISO 2555 and in particular at room temperature (20° C.) and 10 s-1 The viscosity in this respect is determined at a shear rate of 100 Å. This viscosity can be determined in particular using a rotational viscometer. The defined viscosity allows particularly good performance during drying or spray drying, thereby obtaining the composition according to the invention.
[0220] As far as the composition obtained in process step (ii) is concerned, it may comprise or consist of a plurality of individual particles. According to the present invention, it is provided that each particle comprises gum arabic as polysaccharide-based carrier material.
[0221] In this context, it can be provided in particular that the gum arabic and / or polysaccharide-based carrier material has medium chain triglycerides (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 The particles comprise gum arabic and / or a polysaccharide-based carrier material and a medium chain triglyceride (MCT) (particularly at least one linear saturated C6, C8, C 10 or C 12 carboxylic acid binding and / or triglycerides immobilized on a polysaccharide-based carrier material).
[0222] Based on the method according to the invention, the particle size can be adjusted in method step (i) and / or method step (ii).
[0223] In the method according to the invention, the particle size can be adjusted in particular as follows:
[0224] the particles of the composition have a D90 particle size, in particular a D90 particle diameter, in the range of 0.01 mm to 5 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.2 mm to 0.8 mm; this is determined in particular by light diffraction, preferably using laser diffraction according to ISO 13320:2020; and / or
[0225] the particles of the composition have a D50 particle size, in particular a D50 particle diameter, in the range of 0.01 mm to 3 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.15 mm to 0.75 mm; this is determined in particular using light diffraction, preferably by laser diffraction according to ISO 13320:2020;
[0226] In particular, in method step (i), the particle size is adjusted, in particular on the basis of and / or by homogenization, in particular high-pressure homogenization, and / or in method step (ii), the particle size is adjusted on the basis of and / or by drying, in particular spray drying; preferably, in method step (ii), the particle diameter is adjusted on the basis of and / or by drying, in particular spray drying.
[0227] Furthermore, the residual moisture content of the composition can be adjusted in process step (ii) as part of the process according to the invention.
[0228] In particular, in process step (ii), the composition can be adjusted to a residual moisture content of at most 5 wt.%, in particular at most 4 wt.%, preferably at most 3 wt.%, based on the composition.
[0229] Furthermore, in process step (ii), the composition can be adjusted to a residual moisture content of at least 0.1 wt.%, in particular at least 0.25 wt.%, preferably at least 0.5 wt.%, based on the composition.
[0230] Furthermore, in process step (ii), the composition can be adjusted to a residual moisture content in the range of 0.1 wt.% to 5 wt.%, in particular in the range of 0.25 wt.% to 4 wt.%, preferably in the range of 0.5 wt.% to 3 wt.%, based on the composition.
[0231] In the process according to the invention, further drying can be carried out after the drying, in particular spray drying, carried out in process step (ii). In particular, further drying can be carried out downstream of the drying, in particular spray drying, carried out in process step (ii). In this case, further and / or subsequent drying can be carried out for the purpose of (further) adjusting the residual moisture content of the composition, in particular as described above.
[0232] According to the invention, in process step (ii), drying, in particular spray drying, can be carried out by atomizing and / or spraying the dispersion, in particular the emulsion, obtained in process step (i).
[0233] Furthermore, in process step (ii), drying, in particular spray drying, can be carried out by conveying and / or spraying the dispersion, in particular the emulsion, obtained in process step (i), in particular under (high) pressure, through at least one nozzle.
[0234] In the process according to the invention, at least one emulsifier can be added or used in process step (i) and / or process step (ii), in particular in process step (i) as defined above.
[0235] According to the invention, it is also possible to proceed in such a way that, after carrying out process step (ii), at least one emulsifier is added to the composition obtained, in particular as defined above, in particular by spraying or mixing and / or incorporation.
[0236] For further details of the method according to this aspect of the invention, reference may also be made to the explanations of the other aspects of the invention, which are also applicable to this aspect of the invention.
[0237] In addition, according to a fifth aspect of the present invention, the present invention also aims to provide a method for controlling and / or regulating the effect of a polysaccharide-based carrier material comprising or formed from gum arabic on at least one medium-chain triglyceride (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 A method for loading, in particular the loading amount, of at least one triglyceride of a carboxylic acid, in particular for preparing a granular and / or powder composition comprising medium-chain triglycerides (MCTs), preferably for preparing a composition as described above, wherein the loading, in particular the loading amount, is controlled and / or adjusted depending on the glycoprotein content of the polysaccharide-based carrier material.
[0238] In this case, the glycoprotein content of gum arabic may be at least 4 wt.%, and preferably within a range of 4 to 25 wt.%, based on gum arabic.
[0239] Furthermore, the loading, in particular the loading amount, of triglyceride may be at least 50 wt.%, and preferably in the range of 50 to 90 wt.%, based on the total amount of polysaccharide-based carrier material and triglyceride, in particular based on the composition.
[0240] For further details of this aspect of the present invention, reference may also be made to the explanations according to other aspects of the present invention, which are also applicable to this aspect of the present invention.
[0241] In addition, according to the sixth aspect of the present invention, another object of the present invention is to use the glycoprotein content of the polysaccharide-based carrier material comprising gum arabic or formed from gum arabic according to the present invention to control and / or regulate the glycoprotein content of the polysaccharide-based carrier material to at least one medium-chain triglyceride (MCT), in particular to at least one linear saturated C6, C8, C 10 or C 12 The use of a load, in particular a load amount, of at least one triglyceride of a carboxylic acid is particularly useful for preparing a granular and / or powder composition comprising medium chain triglycerides (MCT), preferably for preparing a composition according to the invention as described above.
[0242] In this case, the glycoprotein content of gum arabic is at least 4 wt.%, and preferably ranges from 4 wt.% to 25 wt.%, relative to gum arabic.
[0243] Furthermore, the loading, in particular the loading amount, of triglyceride may be at least 50 wt.%, preferably in the range of 50 wt.% to 90 wt.%, based on the total amount of polysaccharide-based carrier material and triglyceride, in particular based on the composition.
[0244] For more details about this aspect of the invention, reference may also be made to the explanations of other aspects of the invention, which are also applicable to this aspect of the invention.
[0245] The following will be combined with the accompanying drawings ( Figure 1 ) provides a more detailed description of the present invention, particularly for further describing the method of the present invention, particularly for preparing the composition of the present invention. Other advantages, properties, aspects, and features of the present invention are also illustrated in conjunction with the following description of the method of the present invention, but the following description of the method of the present invention does not limit the present invention in any way.
[0246] In the only accompanying figure, Figure 1 A schematic diagram or overview based on a flow chart of the process according to the invention for preparing a composition according to the invention (composition P), in particular a granular composition P, preferably a composition P in powder form, preferably a composition P in powder form comprising medium chain triglycerides (MCT) is shown.
[0247] Figure 1 A method according to one embodiment of the present invention is shown, firstly providing a starting component in the form of medium chain triglycerides (MCTs), and a special gum arabic used as a carrier material. Figure 1 The subsequent implementation of the method of the invention for obtaining the composition P of this aspect in the order of method steps (i) and (ii) is further shown. In method step (i), a preferably aqueous homogeneous dispersion, in particular a preferably aqueous homogeneous emulsion, is provided or prepared, which comprises, on the one hand, gum arabic, in particular as a polysaccharide-based carrier material, and, on the other hand, at least one medium-chain triglyceride (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 At least one triglyceride of a carboxylic acid.
[0248] The glycoprotein content of the gum arabic used in the process of the present invention is at least 4 wt.%, preferably in the range of 4 wt.% to 20 wt.%, based on the gum arabic, and the amount of triglycerides used is at least 50 wt.%, preferably in the range of 50 wt.% to 90 wt.%, based on the dry weight of the dispersion (especially the emulsion).
[0249] In method step (i), the method can be carried out in particular by introducing shear energy or shear forces. In particular, in method step (i), the homogenization of the components can be carried out, for example, by high-pressure homogenization.
[0250] Figure 1 Also shown is the subsequent implementation of method step (ii) after method step (i), wherein in (ii), the dispersion, in particular the emulsion obtained in method step (i) is dried, in particular spray-dried, wherein the liquid carrier medium, which is preferably aqueous, is at least essentially completely removed, in particular in order to obtain a particulate composition P, preferably a composition P in powder form, preferably a composition P in powder form comprising medium-chain triglycerides (MCT), in particular a composition P as defined above.
[0251] In process step (ii), in particular the particle size of the particles on which the composition P according to the invention is based and also the residual moisture content of the composition P can also be adjusted.
[0252] Based on the process according to the invention, as described above, the corresponding compositions P according to the invention have improved properties in this respect.
[0253] Further embodiments, modifications and variations of the present invention, as well as advantages, will be apparent and achievable to those skilled in the art upon reading the specification without departing from the scope of the present invention.
[0254] The following examples are only used to illustrate the present invention, but not to limit the present invention.
[0255] Example:
[0256] In the context of the following processing examples or studies, the excellent properties of the composition of the present invention are shown, in particular with regard to providing high loading levels of medium-chain triglycerides (MCT). In this respect, the applicant has been able to show that the use of a special gum arabic as a polysaccharide-based carrier material for medium-chain triglycerides (MCT) (i.e., gum arabic having a high glycoprotein content in a special manner, at least 4 wt.% calculated on the basis of the gum arabic) enables high loading levels or high contents of medium-chain triglycerides (MCT) to be achieved, such that the triglyceride content of the composition or granule is at least 50 wt.%, calculated on the basis of the composition or granule. Specifically:
[0257] a) Preparation of the MCT composition of the present invention
[0258] The compositions of the present invention can be prepared starting with the ingredients or components that form the composition, as follows.
[0259] Specifically, it can be done in this way: first, a homogeneous dispersion of a preferably aqueous phase, in particular a preferably aqueous homogeneous emulsion, is prepared using water, a polysaccharide-based carrier material based on a special gum arabic, and medium-chain triglycerides. For example, for this purpose, so-called "mixing" can be carried out. First, water is added, then the gum arabic is added thereto, and then these components are mixed (stirred). Then the medium-chain triglycerides or MCT oil are added and mixed to obtain a premix or "premix". This premix is then subjected to a high-pressure homogenization process or sent to a high-pressure homogenization process and homogenized on this basis. The resulting emulsion is then spray-dried. In order to achieve the best results, the emulsion to be sprayed needs to be adjusted to a specific viscosity, which also depends on the nozzle used for spray drying. During the production process, in particular during the spray drying process, the granular or powdered composition obtained according to the present invention on this basis also needs to be adjusted to a defined residual moisture content, which should generally not exceed 5% by weight based on the composition.
[0260] b) Preparation and testing of MCT compositions
[0261] Based on the manufacturing information given in part a), compositions of the present invention (compositions C, D, E) and corresponding comparative compositions (compositions A, B) were provided and their properties were studied as described below.
[0262] In the corresponding compositions, the glycoprotein content and the corresponding loading of medium-chain triglycerides (MCT) of the composition or granules are adjusted or varied relative to gum arabic according to the table below. Based on the corresponding combinations of values for glycoprotein content and MCT loading (as shown in the table below), it is possible, in principle, to obtain storage-stable and emulsifiable powders, which, despite the higher MCT loading, have improved properties in this respect, as also described below.
[0263] The compositions were tested or investigated with respect to various parameters, namely: (i) emulsification in water at room temperature, (ii) optical properties and quality of the resulting emulsions in each case, and (iii) stability of the resulting emulsions over a period of 10 to 15 minutes. The evaluation was summarized based on the above parameters according to a school grading system (1-6, where 1 = very good and 6 = unsatisfactory). The results are shown in the table below.
[0264] Table: Properties of MCT-containing compositions
[0265]
[0266] Compositions C, D, and E of the present invention generally exhibit excellent performance across the evaluated criteria, while also possessing very high medium-chain triglyceride loadings. Based on this, the compositions of the present invention can also be used to produce corresponding food, pharmaceutical, or cosmetic products with high MCT content, a uniform emulsion structure, and simultaneously high storage stability.
[0267] c) Study on the residual moisture content of MCT-containing compositions
[0268] Based on the table given in section b), corresponding compositions with different residual moisture contents were prepared. The best overall performance of the corresponding compositions in terms of storage time, storage stability, and emulsification behavior was determined for residual moisture contents of up to 5 wt.%, based on the corresponding composition. When the corresponding residual moisture content exceeds 5 wt.%, the relevant properties are impaired. In particular, the formation of lumps or agglomerates is often observed after a defined storage time, but the degree of lumps or agglomerations is significantly lower for inventive compositions C, D, and E than for comparative compositions A and B. Thus, the degree of cohesion of the inventive compositions does not exceed 2%, while the cohesion values for the comparative compositions are in each case above 7%. When the corresponding residual moisture content falls below 0.1 wt.%, the overall performance of the compositions deteriorates; in particular, the compositions tend to form a certain amount of dust, and emulsion formation is also affected when added to water. However, inventive compositions C to E exhibit better performance in this respect than comparative compositions A or B, even at very low residual moisture contents.
[0269] d) using the MCT composition of the present invention to prepare a skin cream
[0270] Based on compositions C to E according to the present invention, corresponding skin-protecting or skin-care creams are prepared, i.e., based on the three phases of the combination described below. The first phase comprises the corresponding composition according to the present invention and, in particular, an oil, fat, or wax component. The second phase is based on water, monoglycerides, and zinc sulfate. The third phase comprises tocopherol and a fragrance or aroma component. To prepare the corresponding cosmetic product, the first and second phases are first heated. The second phase is then added to the first phase with stirring, followed by homogenization. The resulting phase is then cooled, after which the third phase is added and further homogenized. Thus, the corresponding skin-protecting or skin-care creams can be obtained as cosmetic products using the corresponding compositions according to the present invention. The cosmetic products are storage-stable and have a high content of medium-chain triglycerides. This results in excellent spreadability, even when applied to the skin. They also have excellent skin-care benefits.
[0271] The above description shows that the compositions according to the invention and the products or preparations based thereon have advantageous properties, in particular with regard to the formation of stable emulsions, high storage stability, high MCT content and good spreading and handling properties.
Claims
1. A composition, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular for use in cosmetic, pharmaceutical or food products, in, The composition comprises or consists of a plurality of individual particles, Each particle comprises at least one polysaccharide-based carrier (i.e., support) material, wherein the polysaccharide-based carrier (i.e., support) material is provided with and / or loaded with at least one medium-chain triglyceride (MCT), in particular provided with and / or loaded with at least one linear saturated C6, C8, C 10 or C 12 At least one triglyceride of a carboxylic acid, and / or wherein each particle comprises at least one polysaccharide-based carrier (i.e., support) material and at least one medium-chain triglyceride (MCT) bound and / or fixed to the polysaccharide-based carrier (i.e., support) material, in particular at least one linear saturated C6, C8, C 10 or C 12 at least one triglyceride of a carboxylic acid; wherein the polysaccharide-based carrier (i.e., support) material comprises or is formed of gum arabic, wherein the glycoprotein content of the gum arabic is at least 4 wt.%, and preferably in the range of 4 wt.% to 25 wt.%, based on the gum arabic; and Wherein, the triglyceride content of the composition or granule is at least 50 wt.%, and preferably in the range of 50 wt.% to 90 wt.%, based on the composition or granule.
2. The composition according to claim 1, in, The glycoprotein content of the gum arabic is at least 4.5 wt.%, in particular at least 5 wt.%, preferably at least 5.5 wt.%, and preferably at least 6 wt.%, calculated on the basis of the gum arabic.
3. The composition according to claim 1, in, The glycoprotein content of the gum arabic is at most 25 wt.% based on the gum arabic.
4. The composition according to claim 1, in, The glycoprotein content of the gum arabic is at most 22 wt.%, in particular at most 20 wt.%, preferably at most 18 wt.%, preferably at most 16 wt.%, calculated on the basis of the gum arabic.
5. The composition according to any one of the preceding claims, in, The glycoprotein content of the gum arabic is in the range of 4.5 wt.% to 22 wt.%, particularly in the range of 5 wt.% to 20 wt.%, preferably in the range of 5.5 wt.% to 18 wt.%, and more preferably in the range of 6 wt.% to 16 wt.%, calculated on the basis of the gum arabic.
6. The composition according to any one of the preceding claims, in, The triglyceride content of the composition or granule is at least 55 wt.%, in particular at least 57.5 wt.%, preferably at least 60 wt.%, preferably at least 65 wt.%, based on the composition or granule.
7. The composition according to any one of the preceding claims, in, The triglyceride content of the composition or granule is at most 90 wt.% based on the composition or granule.
8. The composition according to any one of the preceding claims, in, The triglyceride content of the composition or granule is at most 87.5 wt.%, in particular at most 85 wt.%, preferably at most 82.5 wt.%, preferably at most 80 wt.%, based on the composition or granule.
9. The composition according to claim 1 , wherein the triglyceride content of the composition or granules is in the range of 55 to 87.5 wt.%, in particular in the range of 57.5 to 85 wt.%, preferably in the range of 60 to 82.5 wt.%, preferably in the range of 65 to 80 wt.%, based on the composition or granules.
10. The composition according to any one of the preceding claims, in, The composition or granule has a gum arabic content of at most 50 wt.%, preferably in the range of 10 wt.% to 50 wt.%, based on the composition or granule.
11. The composition according to any one of the preceding claims, in, The composition or granules may have a gum arabic content of at most 45 wt.%, in particular at most 42.5 wt.%, preferably at most 40 wt.%, preferably at most 35 wt.%, based on the composition or granules.
12. The composition according to any one of the preceding claims, in, The gum arabic content of the composition or granules is in the range of 12.5 wt.% to 45 wt.%, particularly in the range of 15 wt.% to 42.5 wt.%, preferably in the range of 17.5 wt.% to 40 wt.%, preferably in the range of 20 wt.% to 35 wt.%, based on the composition or granules.
13. The composition according to any one of the preceding claims, in, The glycoprotein content of the gum arabic is at least 4.5 wt.%, calculated on the basis of gum arabic, and the triglyceride content of the composition or granule is at least 55 wt.%, calculated on the basis of the composition or granule; or wherein the glycoprotein content of the gum arabic is at least 5 wt.%, calculated on the basis of the gum arabic, and wherein the triglyceride content of the composition or granule is at least 57.5 wt.%, calculated on the basis of the composition or granule; or wherein the glycoprotein content of the gum arabic is at least 5.5 wt.%, calculated on the basis of the gum arabic, and wherein the triglyceride content of the composition or granule is at least 60 wt.%, calculated on the basis of the composition or granule; or wherein the glycoprotein content of the gum arabic is at least 6 wt.% based on the gum arabic, and wherein the triglyceride content of the composition or granule is at least 65 wt.% based on the composition or granule.
14. The composition according to any one of the preceding claims, in, The glycoprotein content of the gum arabic is at most 25 wt.%, calculated on the basis of gum arabic, and the triglyceride content of the composition or granule is at most 90 wt.%, calculated on the basis of the composition or granule; or wherein the glycoprotein content of the gum arabic is at most 22 wt.%, calculated as gum arabic, and wherein the triglyceride content of the composition or granule is at most 87.5 wt.%, calculated as the composition or granule; or wherein the glycoprotein content of the gum arabic is at most 20 wt.%, calculated as gum arabic, and wherein the triglyceride content of the composition or granule is at most 85 wt.%, calculated as the composition or granule; or wherein the glycoprotein content of the gum arabic is at most 18 wt.%, calculated as gum arabic, and wherein the triglyceride content of the composition or granule is at most 82.5 wt.%, calculated as the composition or granule; or wherein the glycoprotein content of the gum arabic is at most 16 wt.%, based on the gum arabic; and wherein the triglyceride content of the composition or granules is at most 80 wt.%.
15. The composition according to any one of the preceding claims, in, The glycoprotein content of the gum arabic is in the range of 4 wt.% to 25 wt.% based on gum arabic, and the triglyceride content of the composition or granule is in the range of 50 wt.% to 90 wt.% based on the composition or granule; or wherein the glycoprotein content of the gum arabic is in the range of 4.5 wt.% to 22 wt.% based on the gum arabic, and wherein the triglyceride content of the composition or granules is in the range of 55 wt.% to 87.5 wt.% based on the composition or granules; or wherein the glycoprotein content of the gum arabic is in the range of 5 wt.% to 20 wt.% based on the gum arabic, and wherein the triglyceride content of the composition or granules is in the range of 57.5 wt.% to 85 wt.% based on the composition or granules; or wherein the glycoprotein content of the gum arabic is in the range of 5.5 wt.% to 18 wt.% based on the gum arabic, and wherein the triglyceride content of the composition or granules is in the range of 60 wt.% to 82.5 wt.% based on the composition or granules; or wherein the glycoprotein content of the gum arabic is in the range of 6 wt.% to 16 wt.% based on the gum arabic, and wherein the triglyceride content of the composition or granules is in the range of 65 wt.% to 80 wt.% based on the composition or granules.
16. The composition according to any one of the preceding claims, in, The gum arabic is natural based and / or of natural origin, in particular of plant-based origin; and / or Therein, the gum arabic is based on and / or derived from a plant-based exudate, in particular based on and / or derived from a plant-based exudate of the acacia tree, in particular the acacia tree (Acacia senegal, or synonymously Acacia senegal).
17. The composition according to any one of the preceding claims, in, The gum arabic is obtained from and / or derived from the Acacia tree, in particular the Acacia catechu (Acacia senegalensis, or synonymously Acacia senegalensis); and / or Gum arabic is obtained from or is based on the exudates of the acacia tree, in particular the acacia catechu (Senegal catechu, or synonymously Acacia senegal).
18. The composition according to claim 1, wherein the glycoprotein content of the gum arabic is controlled and / or adjusted by selecting the gum arabic, in particular by selecting the (plant) material or (plant) species for obtaining the gum arabic, preferably based on exudates, optionally with additional enrichment, in particular by fractionation, Especially wherein the (plant) material or (plant) species is selected from the group of acacia trees, especially the acacia tree (Acacia senegal or synonymously Acacia senegal).
19. The composition according to any one of the preceding claims, in, The glycoprotein content of gum arabic is controlled and / or set by enrichment, in particular using fractionation.
20. The composition according to any one of the preceding claims, in, The glycoprotein content refers to the total content of all glycoproteins present in gum arabic; and / or wherein the glycoprotein content refers to the total content of all glycoproteins present in gum arabic; and / or wherein the glycoprotein content is provided and / or formed by molecules, in particular macromolecules, comprising at least one protein and / or protein residue and / or a group having one or more carbohydrate groups, in particular covalently bound carbohydrate groups, attached thereto; in particular, wherein the carbohydrate groups are selected from monosaccharides, disaccharides, oligosaccharides and / or polysaccharides, preferably from oligosaccharide and in particular polysaccharide groups; and / or Wherein, the glycoprotein content is determined by weight average molecular weight In 10 4 g / mol to 10 7 g / mol range, especially in the 1x10 5 g / mol to 9x 10 6 g / mol range, preferably 1.5 x 10 5 g / mol to 6 x 10 6 g / mol range of glycoproteins provided and / or formed; and / or wherein the glycoprotein content is at least partially, in particular predominantly, provided and / or formed by arabinogalactan protein; and / or wherein, based on the glycoprotein content, at least 50%, in particular at least 60%, preferably at least 65% of the glycoprotein content is provided and / or formed by arabinogalactan protein; and / or Wherein, based on the glycoprotein content, 50% to 99%, in particular 60% to 98%, preferably 65% to 95% of the glycoprotein content is provided and / or formed by arabinogalactan protein.
21. The composition according to claim 1, The gum arabic contains, in particular as a main component, at least one polysaccharide, preferably at least one polysaccharide containing an acidic alkali metal and / or alkaline earth metal salt of (poly)arabic acid, particularly preferably at least one preferably branched polysaccharide of L-arabinose, D-galactose, L-rhamnose and D-glucuronic acid.
22. The composition according to any one of the preceding claims, wherein the polysaccharide content of the gum arabic is in the range of 75 wt.% to 96 wt.% based on the gum arabic; and / or in, The polysaccharide content of the gum arabic is at least 75 wt.%, calculated on the basis of gum arabic, and / or Wherein, calculated on the basis of gum arabic, the polysaccharide content of the gum arabic is at most 96 wt.%.
23. The composition according to any one of the preceding claims, wherein the polysaccharide content of the gum arabic is in the range of 78 wt.% to 95.5 wt.%, particularly in the range of 80 wt.% to 95 wt.%, preferably in the range of 82 wt.% to 94.5 wt.%, more preferably in the range of 84 wt.% to 94 wt.%; and / or in, The polysaccharide content of the gum arabic is at least 78 wt.%, in particular at least 80 wt.%, preferably at least 82 wt.%, preferably at least 84 wt.%, and / or Calculated on the basis of gum arabic, the polysaccharide content of the gum arabic is at most 95.5 wt.%, in particular at most 95 wt.%, preferably at most 94.5 wt.%, and preferably at most 94 wt.%.
24. The composition according to any one of the preceding claims, in, Medium chain triglycerides (MCT) are triglycerides of C8 carboxylic acids, in particular triglycerides of linear saturated C8 carboxylic acids; and / or Wherein, the medium chain triglyceride (MCT) is tricaprylin.
25. The composition according to any one of the preceding claims, in, Medium chain triglycerides (MCT) are C8 and C 10 Mixed triglycerides of carboxylic acids, especially straight chain saturated C8 and C 10 mixed triglycerides of carboxylic acids; In particular, the C8:C 10 The ratio is in the range of 30%-90%:70%-10%, particularly in the range of 50%-80%:50%-20%, and preferably in the range of 55%-75%:45%-25%.
26. The composition according to any one of the preceding claims, in, The composition has a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 0.5 mmol / g.
27. The composition according to any one of the preceding claims, in, The composition has a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 1 mmol / g, particularly at least 2 mmol / g, preferably at least 3 mmol / g, and preferably at least 4 mmol / g.
28. The composition according to any one of the preceding claims, in, The composition has a ketone body index (ketogenic index), calculated as theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 0.5 mmol / g to 50 mmol / g.
29. The composition according to any one of the preceding claims, The composition has a ketone body index (ketogenic index), calculated as the theoretical millimoles (mmol) of 3-hydroxybutyric acid (3-BHB) per gram of the composition, in the range of 1 mmol / g to 45 mmol / g, particularly in the range of 2 mmol / g to 40 mmol / g, preferably in the range of 3 mmol / g to 30 mmol / g, and preferably in the range of 4 mmol / g to 25 mmol / g.
30. The composition according to any one of the preceding claims, in, The composition has a ketone body index (ketogenic index), calculated as theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 0.5 mmol / g, and wherein the gum arabic has a glycoprotein content of at least 4 wt.%, based on gum arabic, and wherein the composition or granule has a triglyceride content of at least 50 wt.%, based on the composition or granule; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 1 mmol / g, and wherein the gum arabic has a glycoprotein content of at least 4.5 wt.%, based on gum arabic, and wherein the composition or granule comprises a triglyceride content of at least 55 wt.%, based on the composition or granule; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 2 mmol / g, and wherein the glycoprotein content of the gum arabic, calculated as gum arabic, is at least 5 wt.%, and wherein the triglyceride content of the composition or granules, calculated as the composition or granules, is at least 57.5 wt.%; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 3 mmol / g, and wherein the glycoprotein content of gum arabic, calculated as gum arabic, is at least 5.5 wt.%, and wherein the triglyceride content of the composition or granules, calculated as the composition or granules, is at least 60 wt.%; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, of at least 4 mmol / g, and wherein the glycoprotein content of the gum arabic is at least 6 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granules is at least 65 wt.%, based on the composition or granules.
31. The composition according to any one of the preceding claims, in, The composition has a ketone body index (ketogenic index) calculated as theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition in the range of 0.5 mmol / g to 50 mmol / g, and wherein the glycoprotein content of the gum arabic is in the range of from 4 wt.% to 25 wt.%, based on gum arabic, and wherein the triglyceride content of the composition or granule is in the range of 50 wt.% to 90 wt.%, based on the composition or granule; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 1 mmol / g to 45 mmol / g, and wherein the glycoprotein content of the gum arabic is in the range of 4.5 wt.% to 22 wt.%, and wherein the triglyceride content of the composition or granules is in the range of 55 wt.% to 87.5 wt.%, based on the composition or granules; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 2 mmol / g to 40 mmol / g, and wherein the glycoprotein content of the gum arabic, calculated as gum arabic, is in the range of 5 wt.% to 20 wt.%, and wherein the triglyceride content of the composition or granules, calculated as the composition or granules, is in the range of 57.5 wt.% to 85 wt.%; or wherein the composition has a ketone body index (ketogenic index), calculated as the number of theoretical millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition, in the range of 3 mmol / g to 30 mmol / g, and wherein the glycoprotein content of the gum arabic is in the range of 5.5 wt.% to 18 wt.%, and wherein the triglyceride content of the composition or granules is in the range of 60 wt.% to 82.5 wt.%, based on the composition or granules; or wherein the composition has a ketone body index (ketogenic index) calculated as the theoretical number of millimoles (mmol) of 3-hydroxybutyrate (3-BHB) per gram of the composition in the range of 4 mmol / g to 25 mmol / g, and wherein the glycoprotein content of the gum arabic is in the range of 6 wt.% to 16 wt.% based on gum arabic, and wherein the triglyceride content of the composition or granules is in the range of 65 wt.% to 80 wt.% based on the composition or granules.
32. The composition according to any one of the preceding claims, in, The composition comprises at least one emulsifier.
33. The composition according to claim 32, in, The composition comprises an emulsifier in an amount of at least 0.0001 wt.%, in particular at least 0.001 wt.%, preferably at least 0.01 wt.%, based on the composition; and / or wherein the composition comprises an emulsifier in an amount of at most 5 wt.%, in particular at most 2.5 wt.%, preferably at most 1 wt.%, based on the composition; and / or Wherein, based on the composition, the amount of the emulsifier included in the composition is in the range of 0.0001 wt.% to 5 wt.%, particularly in the range of 0.001 wt.% to 2.5 wt.%, and preferably in the range of 0.01 wt.% to 1 wt.%.
34. The composition according to claim 32 or 33, wherein the emulsifier is an amphoteric emulsifier, an anionic emulsifier, a cationic emulsifier or a nonionic emulsifier; and / or wherein the emulsifier is selected from the following group: fatty acid glycerides, in particular fatty acid monoglycerides and diglycerides, and salts thereof; citric acid esters of fatty acid glycerides, in particular citric acid esters of fatty acid monoglycerides and diglycerides, and salts thereof; tartaric acid esters and monoacetyl tartaric acid esters and diacetyl tartaric acid esters of fatty acid glycerides, in particular tartaric acid esters and diacetyl tartaric acid esters of fatty acid glycerides, and salts thereof; acetate esters of fatty acid glycerides, in particular acetate esters of fatty acid monoglycerides and diglycerides, and salts thereof; lactic acid esters of fatty acid glycerides, in particular monoglycerides and diglycerides; Lactic acid esters of diglycerides, and salts thereof; mixed acetic acid and tartaric acid esters of fatty acid glycerides, in particular mixed acetic acid and tartaric acid esters of fatty acid monoglycerides and diglycerides, and salts thereof; polyglycerol fatty acid esters, in particular polyglycerol mono-, di- and poly-fatty acid esters, preferably polyglycerol polyricinoleate; preferably sorbitan esters of fatty acids, in particular polyoxyethylene sorbitan esters, preferably polyoxyethylene sorbitan monoesters, in particular polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate esters and polyoxyethylene sorbitan tristearate; ethoxylated fatty alcohols; ethoxylated fatty acid glycerides, in particular ethoxylated fatty acid mono- and diglycerides, and their salts; alkyl polyglucosides and sugar glycerides, in particular cetearyl glucoside; sugar esters of fatty acids, in particular sucrose fatty acid esters; modified starches; modified celluloses; quaternary ammonium compounds (esterquats); lecithins; phospholipids; alkyl glucose sesquistearate, in particular methyl glucose sesquistearate; fatty alcohols; fatty acids and their salts and esters; silicones and silicones; polydimethylsiloxanes and modified polydimethylsiloxanes alkyl sarcosinates, in particular sodium alkyl sarcosinates, preferably alkali metal lauryl sarcosinates; amino acid acyl esters and salts thereof; POE / PPG copolymers; phosphates (phosphonates) and salts thereof, in particular cetyl phosphates, preferably alkali metal cetyl phosphates, preferably potassium cetyl phosphates; polyacrylates; castor oil and modified castor oils, in particular PEG castor oil and PEG castor oil fatty acid esters and difatty acid esters; ethoxylated alkyl sulfates and alkyl ether sulfates; alkyl ether sulfates; and combinations and mixtures thereof.
35. A composition according to any one of claims 32 to 34, wherein the emulsifier is bound and / or immobilized to the particles; and / or wherein the composition comprises an emulsifier bound and / or immobilized in the form of the particles.
36. A composition according to any one of claims 32 to 35, wherein the emulsifier is in particulate form and / or in the form of emulsifier particles; and / or The compositions therein comprise the emulsifier in the form of individual, in particular unbound and / or free, emulsifier particles.
37. The composition according to any one of the preceding claims, in, The particles of the composition each comprise and / or are formed from a plurality of elementary particles (base particles), in particular wherein the elementary particles are composited and / or agglomerated with one another, and / or in particular wherein the elementary particles each comprise or are formed from at least one medium-chain triglyceride and gum arabic, preferably each have a core / shell structure and / or are preferably each a core / shell elementary particle, preferably wherein the core comprises or is formed from at least one medium-chain triglyceride and the shell comprises or is formed from gum arabic, and / or wherein the particles of the composition each comprise and / or are formed of a plurality of elementary particles (base particles) that are bound and / or agglomerated to one another, in particular wherein the elementary particles each comprise or are formed of at least one medium-chain triglyceride and gum arabic, preferably each have a core / shell structure and / or are preferably each a core / shell elementary particle, preferably wherein the core comprises or is formed of at least one medium-chain triglyceride and the shell comprises or is formed of gum arabic; and / or In particular, the at least one medium-chain triglyceride is also present on the surface of the core / shell structure and / or the core / shell base particle, in particular on the shell.
38. The composition according to any one of the preceding claims, wherein the composition is free-flowing and / or flowable; and / or wherein the composition is at least substantially free of lumps; and / or The composition is at least substantially free of particle agglomerates or clusters, in particular large agglomerates of particles having a size greater than 5 mm, in particular greater than 4.5 mm, preferably greater than 4 mm, particularly preferably greater than 3.5 mm.
39. The composition according to any one of the preceding claims, in, The residual moisture content of the composition is at most 5 wt.%, in particular at most 4 wt.%, preferably at most 3 wt.%, based on the composition; and / or wherein the residual moisture content of the composition is at least 0.1 wt.%, in particular at least 0.25 wt.%, preferably at least 0.5 wt.%, based on the composition; and / or Wherein, the residual moisture content of the composition is in the range of 0.1 wt.% to 5 wt.%, particularly in the range of 0.25 wt.% to 4 wt.%, and preferably in the range of 0.5 wt.% to 3 wt.%, based on the composition.
40. The composition according to any one of the preceding claims, wherein the particles of the composition have a D90 particle size, in particular a D90 particle diameter, in the range of 0.01 mm to 5 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.2 mm to 0.8 mm; in particular determined using light diffraction, preferably determined using laser diffraction according to ISO 13320:2020; and / or The particles of the composition have a D50 particle size, in particular a D50 particle diameter, in the range of 0.01 mm to 3 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.15 mm to 0.75 mm; in particular determined by light diffraction, preferably by laser diffraction according to ISO 13320:2020.
41. The composition according to any one of the preceding claims, in, The composition is at least substantially free of other and / or additional carrier materials, in particular at least substantially free of other and / or additional carrier materials for medium chain triglycerides (MCT); and / or wherein the composition is at least substantially free of other and / or additional carrier materials, in particular at least substantially free of other and / or additional carrier materials for medium chain triglycerides (MCT); and / or wherein the composition is at least substantially free of other and / or additional polysaccharide-based carrier materials; and / or wherein the composition is at least substantially free of other and / or additional polysaccharide-based carrier materials; and / or wherein the composition is at least substantially free of other and / or additional polysaccharide-based carrier materials based on maltodextrin and / or starch, in particular modified starch, and / or wherein the composition is at least substantially free of other and / or additional polysaccharide-based carrier materials based on maltodextrin and / or starch, in particular modified starch; and / or wherein the composition is at least substantially free of carrier materials other than gum arabic, in particular at least substantially free of polysaccharide-based carrier materials other than gum arabic, preferably at least substantially free of gum arabic other than gum arabic; and / or wherein the composition is at least substantially free of carrier materials other than gum arabic, in particular at least substantially free of polysaccharide-based carrier materials other than gum arabic, preferably at least substantially free of gum arabic other than gum arabic; and / or wherein the composition does not contain proteins other than glycoproteins and / or other proteins, in particular does not contain phosphoproteins, preferably does not contain caseins; and / or The composition is free of phosphoprotein, preferably free of casein.
42. A composition, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular for use in a cosmetic, pharmaceutical or food product, preferably a composition according to one of the preceding claims, wherein the composition is obtainable by the method defined in claims 50 to 63 and / or the composition is obtainable by the method defined in claims 50 to 63.
43. Food, cosmetic or pharmaceutical product comprising the composition according to any one of claims 1 to 42.
44. Use of a composition according to any one of claims 1 to 42 in a food, cosmetic or pharmaceutical product and / or for the production of a food, cosmetic or pharmaceutical product.
45. The food, cosmetic or pharmaceutical product according to claim 43, or the use according to claim 44, wherein the food, cosmetic or pharmaceutical product comprises the composition in an amount of at least 0.5 wt.%, in particular at least 1 wt.%, preferably at least 3 wt.%, preferably at least 5 wt.%, based on the product; and / or wherein the food, cosmetic or pharmaceutical product comprises the composition in an amount of at most 90 wt.%, in particular at most 80 wt.%, preferably at most 70 wt.%, preferably at most 60 wt.%, based on the product; and / or Wherein, the amount of the composition contained in the food, cosmetic or pharmaceutical product is in the range of 0.5wt.% to 90wt.%, particularly in the range of 1wt.% to 80wt.%, preferably in the range of 3wt.% to 70wt.%, preferably in the range of 5wt.% to 60wt.%, based on the product.
46. The food, cosmetic or pharmaceutical product according to claim 43, or the use according to claim 44, or the food, cosmetic or pharmaceutical product according to claim 45, or the use according to claim 45, in, The food, cosmetic or pharmaceutical product comprises the composition and at least one carrier (excipient), in particular a physiologically tolerable carrier (excipient).
47. The food, cosmetic or pharmaceutical product according to claim 43, or the use according to claim 44, or the food, cosmetic or pharmaceutical product according to claim 45 or 46, or the use according to claim 45 or 46, The food, cosmetic or pharmaceutical product, in particular the food product, is a functional food, a novel food, a food additive, a food supplement, a dietary food and / or a therapeutic food, an energy snack, an appetite suppressant or a strength and / or endurance sports supplement.
48. The food, cosmetic or pharmaceutical product according to claim 43, or the use according to claim 44, or the food, cosmetic or pharmaceutical product according to any one of claims 45 to 47, or the use according to any one of claims 45 to 47, The food, cosmetic or pharmaceutical product, in particular the cosmetic product, is a personal care and / or body cleansing product, in particular a skin and / or hair care and / or hair cleansing product, preferably a shower gel, shampoo, bath additive, soap, skin cream, lotion, gel, cream, sunscreen, insect repellent, facial mask, shaving foam or soap, tanning agent, depilatory agent, baby care product, beard care product, wet wipes, intimate hygiene product, etc.; a dental and / or oral care product or a tooth and / or oral care product or an oral cleaning product, preferably a toothpaste, mouthwash, an adhesive composition of a tooth replacement product, etc.; a hair treatment product, preferably a hair dye product, a hair styling product, a conditioner, etc.; a smear product for visual and / or decorative purposes, preferably a makeup, a lip care product such as lipstick or lip gloss, an eye care product such as mascara or eye shadow, facial makeup or rouge, nail polish, etc.; a product to improve body odor or a fragrance product, preferably a deodorant, perfume, or light perfume, etc.
49. The food, cosmetic or pharmaceutical product according to claim 43, or the use according to claim 44, or the food, cosmetic or pharmaceutical product according to one of claims 45 to 48, or the use according to one of claims 45 to 48, wherein the food, cosmetic or pharmaceutical product is a liquid, ointment, cream, paste, lotion, gel, spray or solid, powder, tablet, pill, capsule, coated tablet or the like, and / or is formulated and / or designed to be a liquid, ointment, cream, paste, lotion, gel, spray, solid, powder, tablet, pill, capsule, coated tablet or the like; and / or in, The food, cosmetic or pharmaceutical product is designed as a dry preparation, in particular in powder form, wherein the dry preparation is supplied and / or stored and / or added to a liquid, in particular water, in particular on the user and / or consumer side, preferably in the case of application and / or use.
50. A method for preparing a composition, in particular a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular a method for preparing a composition according to claims 1 to 42, in, The method comprises the following method steps, in particular in the order of the method steps given below: (i) providing and / or preparing a preferably aqueous homogeneous dispersion, in particular a preferably aqueous homogeneous emulsion, in a preferably aqueous liquid carrier medium, comprising, on the one hand, gum arabic as a polysaccharide-based carrier material, and, on the other hand, at least one medium-chain triglyceride (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 at least one triglyceride of a carboxylic acid, wherein the glycoprotein content of the gum arabic used is at least 4 wt.% and preferably in the range of 4 wt.% to 20 wt.%, based on the gum arabic, and wherein the amount of triglyceride used is at least 50 wt.%, preferably in the range of 50 wt.% to 90 wt.%, based on the dry weight of the dispersion, in particular the emulsion; subsequently (ii) drying, in particular spray-drying, the dispersion, in particular the emulsion, obtained in step (i) of the process, wherein the preferably aqueous liquid carrier medium is at least substantially completely removed, in particular thereby obtaining a granular composition, preferably a composition in powder form, preferably a composition in powder form comprising medium chain triglycerides (MCT), in particular a composition according to any one of claims 1 to 42.
51. The method according to claim 50, in, Method step (i) is carried out by introducing shear energy and / or shear forces; and / or wherein, in method step (i), homogenization, in particular homogenization of the ingredients, is achieved by introducing shear energy and / or shear forces, in particular wherein the introduction of shear energy and / or shear forces is achieved by high-pressure homogenization and / or using preferably a high-pressure homogenizer; and / or In the method step (i), high-pressure homogenization is particularly performed using a high-pressure homogenizer.
52. The method according to claim 50 or 51, in, High-pressure homogenization is carried out under a pressure gradient of up to 2500 bar, in particular up to 2250 bar, preferably up to 2000 bar; and / or The high-pressure homogenization is carried out under a pressure gradient in the range of 50 bar to 2500 bar, in particular in the range of 75 bar to 2250 bar, preferably in the range of 100 bar to 2000 bar.
53. The method according to any one of claims 50 to 52, in, In method step (i), a two-stage and / or multi-stage method is carried out, in particular, wherein, in method step (i), first, the components are mixed, in particular stirred, preferably by introducing mixing and / or stirring energy and / or stirring forces, in particular to obtain a (pre)dispersion, in particular a (pre)emulsion; subsequently, preferably as defined in claim 51 or 52, a homogenization, in particular a homogenization of the components, is carried out by introducing shear energy and / or shear forces, preferably a high-pressure homogenization of the (pre)dispersion, in particular a (pre)emulsion, in particular to obtain a preferably aqueous homogeneous dispersion, in particular a preferably aqueous homogeneous emulsion of the components.
54. The method according to any one of claims 50 to 53, Therein, in process step (i), a finely divided homogeneous dispersion, in particular a finely divided homogeneous emulsion, is prepared and / or provided.
55. The method according to any one of claims 50 to 54, in, In process step (i), the homogeneous dispersion, in particular the homogeneous emulsion, is set to a viscosity, in particular an apparent viscosity, of at most 2500 mPas, in particular of at most 1000 mPas, preferably of at most 400 mPas, In particular, it is in accordance with DIN EN ISO 2555 and in particular at room temperature (20° C.) and 10 s -1 It is preferably measured using a rotational viscometer at a shear rate of .
56. The method according to any one of claims 50 to 55, in, the composition obtained in process step (ii) comprises or consists of a plurality of individual particles, wherein each particle comprises gum arabic as a polysaccharide-based carrier material, In particular, wherein gum arabic and / or the polysaccharide-based carrier material is provided with and / or loaded with medium chain triglycerides (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 The particles comprise gum arabic and / or a polysaccharide-based carrier material and a medium chain triglyceride (MCT) bound and / or immobilized on the polysaccharide-based carrier material, in particular at least one linear saturated C6, C8, C 10 or C 12 Triglycerides of carboxylic acids.
57. The method according to any one of claims 50 to 56, in, The particle size is set in method step (i) and / or method step (ii).
58. The method according to any one of claims 50 to 57, in, The particle size is set so that The particles of the composition have a D90 particle size, in particular a D90 particle diameter, in the range of 0.01 mm to 5 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.2 mm to 0.8 mm; in particular determined using light diffraction, preferably determined using laser diffraction according to ISO 13320:2020; and / or The particles of the composition have a D50 particle size, in particular a D50 particle diameter, in the range of 0.01 mm to 3 mm, in particular in the range of 0.05 mm to 2 mm, preferably in the range of 0.1 mm to 1 mm, particularly preferably in the range of 0.15 mm to 0.75 mm; in particular determined using light diffraction, preferably determined using laser diffraction according to ISO 13320:2020; In particular, in method step (i), the setting of the particle size is in particular based on and / or achieved using homogenization, in particular high-pressure homogenization, and / or in method step (ii), the setting of the particle size is based on and / or achieved using drying, in particular spray drying, preferably in method step (ii), the setting of the particle size is based on and / or achieved using drying, in particular spray drying.
59. The method according to any one of claims 50 to 58, in, In method step (ii), the residual moisture content of the composition is set; and / or wherein, in method step (ii), the composition is set to a certain residual moisture content, which is at most 5 wt.%, in particular at most 4 wt.%, preferably at most 3 wt.%, based on the composition; and / or wherein, in method step (ii), the composition is set to a certain residual moisture content, which is at least 0.1 wt.%, in particular at least 0.25 wt.%, preferably at least 0.5 wt.%, based on the composition; and / or In this case, in method step (ii), the composition is set to a certain residual moisture content, which is in the range of 0.1 wt.% to 5 wt.%, particularly in the range of 0.25 wt.% to 4 wt.%, and preferably in the range of 0.5 wt.% to 3 wt.%, based on the composition.
60. The method according to any one of claims 50 to 59, in, After the drying, in particular spray drying, in process step (ii), further drying is carried out; and / or wherein further drying is carried out downstream of the drying, in particular spray drying, carried out in process step (ii); In particular, further drying and / or subsequent drying is carried out and / or achieved with the aim of (further) setting the residual moisture content of the composition, in particular as defined in claim 58 .
61. The method according to any one of claims 50 to 60, in, In method step (ii), the drying, in particular spray drying, is carried out by means of atomization and / or spraying of the dispersion, in particular the emulsion, obtained in method step (i); and / or Therein, in process step (ii), the drying, in particular spray drying, is carried out by conveying the dispersion, in particular the emulsion, obtained in process step (i), in particular under (high) pressure, through at least one nozzle and / or spraying it through at least one nozzle.
62. The method according to any one of claims 50 to 61, in, In method step (i) and / or method step (ii), in particular in method step (i), at least one emulsifier, in particular as claimed in any one of claims 33 to 37, is added and / or used.
63. The method according to any one of claims 50 to 62, in, After carrying out process step (ii), at least one emulsifier is added to the resulting composition according to any one of claims 33 to 37, in particular using spraying and / or mixing and / or incorporation.
64. A method for regulating and / or controlling the activity of a polysaccharide-based carrier material comprising or formed from gum arabic to at least one medium chain triglyceride (MCT), in particular at least one linear saturated C6, C8, C 10 or C 12 Method for the preparation of a composition comprising medium-chain triglycerides (MCT) in granular and / or powder form, preferably for the preparation of a composition according to any one of claims 1 to 42, in, The loading, in particular the loading amount, is controlled and / or set depending on the glycoprotein content of the polysaccharide-based carrier material.
65. The method according to claim 64, in, The glycoprotein content of the gum arabic is at least 4 wt.%, and preferably in the range of 4 wt.% to 25 wt.%, based on the gum arabic, and / or Therein, based on the total amount of the polysaccharide-based carrier material and the triglyceride, in particular based on the composition, the loading of the triglyceride, in particular the loading amount, is at least 50 wt.%, preferably in the range of 50 wt.% to 90 wt.%.
66. Use of a polysaccharide-based carrier material comprising gum arabic or formed therefrom for controlling and / or setting the glycoprotein content of the polysaccharide-based carrier material for at least one medium-chain triglyceride (MCT), in particular for at least one linear saturated C6, C8, C 10 or C 12 The loading, in particular the loading amount, of at least one triglyceride of a carboxylic acid is particularly for producing a composition in granular and / or powder form comprising medium-chain triglycerides (MCT), preferably for producing a composition according to one of claims 1 to 42 .
67. The use according to claim 66, in, The glycoprotein content of the gum arabic is at least 4 wt.%, and preferably in the range of 4 wt.% to 25 wt.%, based on the gum arabic, and / or Therein, based on the total amount of the polysaccharide-based carrier material and the triglyceride, in particular based on the composition, the loading of the triglyceride, in particular the loading amount, is at least 50 wt.%, and preferably in the range of 50 wt.% to 90 wt.%.
68. The food, cosmetic or pharmaceutical product according to claim 43 or one of claims 45 to 49, The use according to claim 44 or one of claims 45 to 49, the method according to one of claims 50 to 63, the method according to claim 64 or 65, and the use according to claim 66 or 67, In each case it is characterized by One or more of the features of claims 1 to 42.
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Drug delivery composition comprising polymer-lipid hybrid microparticles
US10463626B2