Spray crystallization reaction tank for morphology of porous anhydrous lactose generated by recrystallization and method thereof
The combination of a multi-stage temperature-controlled jacket assembly and a stirring system solves the problems of uneven heating and solution viscosity in traditional processes, achieves efficient and uniform crystallization of lactose products, and improves product quality and solubility.
Patent Information
- Application Number
- CN202511184403.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-22
- Publication Date
- 2025-10-10
AI Technical Summary
In traditional production processes, there are problems such as uneven heating, solution viscosity, uneven crystal size and uneven purity during catalytic reaction and spray crystallization, which affect the quality and solubility of lactose products.
A multi-stage temperature-controlled jacket assembly and a stirring system are used, combined with a spray tube and a diverter plate. Temperature control is achieved through a multi-stage temperature-controlled jacket assembly. A stirring motor and a stirring rod are used to ensure solution fluidity and uniform spraying. A vacuum pump is used to prevent crystal deposition and achieve rapid crystallization.
It improves the crystallization quality and efficiency, ensures the uniformity and efficiency of the crystallization process, and improves the purity and solubility of lactose products.
Smart Images
Figure CN120754795A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of lactose preparation, and particularly relates to a spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization and a method thereof. BACKGROUND
[0002] In the catalytic reaction stage, in the traditional production process, an internal heating mode is usually adopted to heat the whole catalytic tank, and because the space in the tank is limited, the solution lacks fluidity, and thus the solution close to the tank wall presents a sticky phenomenon, which is not conducive to the transfer crystallization in the later stage.
[0003] In the spray crystallization stage, in the traditional production process, uneven heat distribution is prone to occur, and the solution after catalysis is directly transferred to the crystallization bed, which is prone to affect the internal temperature of the crystallization bed and may cause the size and purity of the crystals to be different, thereby affecting the quality and solubility of the final product. SUMMARY
[0004] To solve the above technical problems, the purpose of the present application is to provide a spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization and a method thereof.
[0005] To achieve the above purpose, the present application adopts the following technical solutions: A spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, comprising a tank body support, a reaction tank connected to the tank body support, a multi-section temperature control jacket assembly connected to the reaction tank, a stirring motor connected to the tank body support at the lower end of the reaction tank, a driving shaft of the stirring motor connected to a driving gear, a stirring shaft penetrating through the bottom of the reaction tank, a driven gear connected to the stirring shaft at the outer side of the reaction tank, the driven gear being engaged with the driving gear, a stirring connecting rod connected to the stirring shaft in the reaction tank, a stirring rod connected to the stirring connecting rod, the stirring rod and the stirring connecting rod forming a U-shaped structure, a detachable tank cover connected to the top of the reaction tank, a spray pipe connected to the tank cover, a flow dividing disc for uniform spraying in the tank body connected to one end of the spray pipe penetrating into the reaction tank, a plurality of flow holes being formed in the flow dividing disc, a plurality of spray pipes corresponding in number to the flow holes being arranged in a circumferential array at the bottom of the flow dividing disc, a plurality of equidistantly spaced spray openings being formed in the spray pipes, the spray openings being directed downward, a vacuum pipe being connected to the tank cover, the vacuum pipe being connected in communication with a vacuum pump through a micro-pressure air inlet valve.
[0006] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the multi-stage control jacket assembly comprises a high-temperature jacket layer, a transition jacket layer and a low-temperature jacket layer, the high-temperature jacket layer, the transition jacket layer and the low-temperature jacket layer are sequentially sleeved on the reaction tank from top to bottom, the high-temperature jacket layer is connected with a high-temperature water tank through a high-temperature circulating pump, the transition jacket layer is connected with a transition water tank through a transition circulating pump, and the low-temperature jacket layer is connected with a low-temperature water tank through a low-temperature circulating pump. Wherein, the temperature of the high-temperature jacket layer is 50~85℃, the temperature of the transition jacket layer is 30~50℃, and the temperature of the low-temperature jacket layer is 20~30℃.
[0007] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the high-temperature jacket layer and the transition jacket layer are connected with a heat insulation layer, and the transition jacket layer and the low-temperature jacket layer are connected with a heat insulation layer.
[0008] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the stirring connecting rod is provided with six, each of the stirring connecting rods is connected with a plurality of stirring rods, and the plurality of stirring rods are sequentially and spaced apart from the outside of the stirring connecting rod to the stirring shaft.
[0009] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the positions of the stirring rods on each of the stirring connecting rods are staggered with the positions of the stirring rods on the adjacent stirring connecting rods.
[0010] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the end of the stirring connecting rod is connected with a scraper for removing crystallization residues on the inner wall of the reaction tank.
[0011] Preferably, the spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, the angle range of the spray port is 45° to 90°, and the angle range of the spray port is sequentially reduced from the outside to the inside of the spray pipe.
[0012] A use method of a spray crystallization reaction tank for generating porous anhydrous lactose morphology by recrystallization, Comprising the following steps: Step 1: injecting the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: starting the high-temperature jacket layer, the transition jacket layer and the low-temperature jacket layer in the multi-stage temperature control jacket assembly to control the temperature of the solution in the reaction tank; Step 3: starting the stirring motor and operating at a speed of 100~200rpm to stir the raw material solution; Step 4: Start spraying, the flow of the spraying port is controlled at 5-20 ml / min, the spraying pressure is at 0.2-0.04 Mpa, the mist droplet diameter is less than 50 μm, and the stirring motor is always in working state during the spraying process; Step 5: Start the vacuum pump, first pump to 0.09 MPa, maintain for 10-15 min, then pump to 0.05-0.06 MPa, and then inject trace amount of sterile air to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and the transition jacket layer, and lower the low-temperature jacket layer to 20°C at a speed of 0.5-1°C per minute, so that rapid crystallization can be achieved; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed, and then recover the lactose from the liquid outlet. If the reaction is slow, increase the flow and pressure of the spraying to make the reaction fast until the reaction is completed. Step 8: After the above reaction is completed, close all devices, and clean the tank.
[0013] Preferably, the method for using the spray crystallization reaction tank for the recrystallization of porous anhydrous lactose includes the following steps: Step 1: Inject the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: Start the high-temperature jacket layer, the transition jacket layer and the low-temperature jacket layer in the multi-stage temperature control jacket assembly to control the temperature of the solution in the reaction tank; Step 3: Start the stirring motor and operate at a speed of 100 rpm to stir the raw material solution; Step 4: Start spraying, the flow of the spraying port is controlled at 5 ml / min, the spraying pressure is at 0.2 Mpa, the mist droplet diameter is less than 50 μm, and the stirring motor is always in working state during the spraying process; Step 5: Start the vacuum pump, first pump to 0.09 MPa, maintain for 10 min, then pump to 0.05 MPa, and then inject trace amount of sterile air to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and the transition jacket layer, and lower the low-temperature jacket layer to 20°C at a speed of 0.5°C per minute, so that rapid crystallization can be achieved; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed, and then recover the lactose from the liquid outlet. If the reaction is slow, increase the flow and pressure of the spraying to make the reaction fast until the reaction is completed. Step 8: After the above reaction is completed, close all devices, and clean the tank.
[0014] Preferably, the method for using the spray crystallization reaction tank for the porous anhydrous lactose morphology generated by the recrystallization comprises the following steps: Step 1: injecting the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: starting the high-temperature jacket layer, the transition jacket layer and the low-temperature jacket layer in the multi-section temperature control jacket assembly to control the temperature of the solution in the reaction tank; Step 3: starting the stirring motor and operating at a speed of 200 rpm to stir the raw material solution; Step 4: starting the spray, controlling the flow of the spray port at 20 ml / min, and the spray pressure at 04 Mpa, wherein the droplet diameter is less than 50 μm, and at the same time, the stirring motor is always in working state during the spraying process; Step 5: starting the vacuum pump, first pumping to 0.09 MPa, maintaining for 15 min, then pumping to 0.06 MPa, and then injecting a small amount of sterile air to prevent crystal deposition; Step 6: stopping the temperature supply of the high-temperature jacket layer and the transition jacket layer, and lowering the low-temperature jacket layer to 20℃ at a speed of 1℃ per minute to achieve rapid crystallization; Step 7: observing the reaction in the tank body through the window of the reaction tank, if the reaction is normal, then waiting for the reaction to complete, and if the reaction is slow, then increasing the flow and pressure of the spray to make it react quickly until the reaction is complete; Step 8: after the above reaction is completed, closing all devices and cleaning the tank body.
[0015] By the above scheme, the present application has at least the following advantages: The present application can improve the crystallization quality and efficiency, the combination of the spray flow dividing disc, the spray pipe and the multi-section temperature control jacket assembly cooling not only refines the spray droplets, increases the surface area, but also ensures the high efficiency and uniformity of heat exchange in the crystallization process through the dynamic cooling design, thereby significantly improving the quality and crystallization rate of the crystallization product.
[0016] The above description is only a summary of the technical scheme of the present application, in order to more clearly understand the technical means of the present application, and can be implemented according to the content of the specification, the following will be described in detail with the preferred embodiments of the present application and the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS
[0017] In order to more clearly illustrate the technical scheme of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments, it should be understood that the following drawings only show some embodiments of the present application, therefore should not be regarded as a limitation on the scope, for those skilled in the art, without creative labor, other related drawings can also be obtained according to these drawings.
[0018] Figure 1 is a structural schematic diagram of the present application; Figure 2 is a structural schematic diagram of the stirring connecting rod and stirring plate of the present application; Figure 3 is a structural schematic diagram of the flow distribution disc and spray pipe of the present application; Figure 4 is an internal structural diagram of the spray pipe of the present application. DETAILED DESCRIPTION
[0019] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings herein can be arranged and designed in various different configurations.
[0020] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without making creative efforts fall within the scope of protection of the present application.
[0021] Embodiment One As Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, a kind of re-crystallization generates porous anhydrous lactose appearance with spray crystallization reaction tank, including tank body support 1, the reaction tank 2 is connected on the tank body support 1, the multi-section temperature control jacket assembly 3 is connected on the reaction tank 2, the stirring motor 4 is connected on the tank body support 1 at the lower end of the reaction tank 2, the driving shaft of the stirring motor 4 is connected with driving gear 5, the stirring shaft 6 is penetrated in the bottom central axis of the reaction tank 2, the driven gear 7 is connected on the stirring shaft 6 outside the reaction tank 2, the driven gear 7 is engaged with driving gear 5, the stirring connecting rod 8 is connected on the stirring shaft 6 in the reaction tank 2, the stirring rod 9 is connected on the stirring connecting rod 8, the stirring rod 9 and stirring connecting rod 8 form U-shaped structure, the detachable tank cover 11 is connected on the top of the reaction tank 2, the spray pipe 12 is connected on the tank cover 11, the end of the spray pipe 12 extending into the reaction tank 2 is connected with the flow dividing disc 13 for uniform spraying in the tank body, a plurality of liquid flow holes are formed in the flow dividing disc 13, a plurality of spray pipes 14 matched with the liquid flow holes are arranged in the bottom circumferential array of the flow dividing disc 13, a plurality of equidistant spray openings are formed in the spray pipe 14, the direction of the spray opening 17 is set to downward, the vacuum pipe 15 is communicated with the tank cover 11, the vacuum pipe 15 is communicated with the vacuum pump 16 through micro-pressure air inlet valve.
[0022] In the application, the temperature of the raw material solution can be controlled to ensure the quality of crystallization, the multi-section control jacket assembly 3 includes a high-temperature jacket layer 31, a transition jacket layer 32 and a low-temperature jacket layer 33, the high-temperature jacket layer 31, the transition jacket layer 32 and the low-temperature jacket layer 33 are sequentially sleeved on the reaction tank 2 from top to bottom, the high-temperature jacket layer 31 is communicated with a high-temperature water tank 35 through a high-temperature circulating pump 34, the transition jacket layer 32 is communicated with a transition water tank 37 through a transition circulating pump 36, and the low-temperature jacket layer 33 is communicated with a low-temperature water tank 39 through a low-temperature circulating pump 38. The temperature of the high-temperature jacket layer 31 is 50-85℃, the temperature of the transition jacket layer 32 is 30-50℃, and the temperature of the low-temperature jacket layer 33 is 20-30℃.
[0023] Different requirements can be realized by different temperature control, and the low-temperature jacket layer is mainly used to realize rapid crystallization, and the above two jacket layers can ensure the fluidity of the raw solution and prevent caking.
[0024] In the application, the high-temperature jacket layer 31 and the transition jacket layer 32 are connected with a heat insulation layer 310, and the transition jacket layer 32 and the low-temperature jacket layer 33 are connected with a heat insulation layer 310, so that the stability of different regions can be locked, and the problem that the temperature of the jacket layers affects each other can be avoided.
[0025] Further, the present application can realize uniform and comprehensive stirring. The stirring connecting rods 8 are provided with 6, and each of the stirring connecting rods 8 is connected with a plurality of stirring rods 9, and the plurality of stirring rods 9 are sequentially and spacedly arranged from the outside of the stirring connecting rod 8 to the stirring shaft, and the positions of the stirring rods on each of the stirring connecting rods 8 are staggered with the positions of the stirring rods on the adjacent stirring connecting rods.
[0026] The above-mentioned multiple stirring connecting rods and staggered distribution of the stirring rods can realize sufficient stirring, thereby improving the crystallization rate.
[0027] Further, the end of the stirring connecting rod 8 is connected with a scraper 10 for removing the crystallization residues on the inner wall of the reaction tank, and the scraper can clean the inside of the reaction tank, thereby preventing the secondary pollution.
[0028] When spraying the raw solution, the angle range of the spraying port is 45° to 90°, and the angle of the spraying port is sequentially decreased from the outside to the inside of the spraying pipe 14, the outermost spraying port is 90°, the 90° spraying port is located at the outermost side, and the closer to the central axis of the reaction tank, the closer to 45° the angle of the spraying port is, so that the raw solution can be fully and uniformly sprayed.
[0029] In the specific implementation, a use method of a spray crystallization reaction tank for generating a porous anhydrous lactose morphology by recrystallization, comprising the following steps: Step 1: injecting the raw solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: starting the high-temperature jacket layer, the transition jacket layer and the low-temperature jacket layer in the multi-section temperature control jacket assembly to control the temperature of the solution in the reaction tank; Step 3: starting the stirring motor and operating at a speed of 100-200 rpm to stir the raw solution; Step 4: opening the spray, the flow rate of the spraying port is controlled to be 5-20 ml / min, the spraying pressure is 0.2-0.04 MPa, the droplet diameter is less than 50 μm, and the stirring motor is always in working state during the spraying process; Step 5: starting the vacuum pump, first pumping to 0.09 MPa, maintaining for 10-15 min, then pumping to 0.05-0.06 MPa, and then injecting a small amount of sterile air to prevent the deposition of the crystal; Step 6: stopping the temperature supply of the high-temperature jacket layer and the transition jacket layer, and lowering the low-temperature jacket layer to 20°C at a speed of 0.5-1°C per minute, so that the rapid crystallization can be realized; Step 7: observing the reaction in the tank through the window of the reaction tank, if the reaction is normal, then waiting for the reaction to complete, and then recovering the lactose from the liquid outlet, if the reaction is slow, then increasing the flow rate and the pressure of the spray to make the reaction fast until the reaction is completed. Step 8: After the above reaction is completed, all devices are closed, and the tank is cleaned.
[0030] Example Two On the basis of Example One, a method for using a spray crystallization reaction tank to generate porous anhydrous lactose morphology by recrystallization, comprising the following steps: Step 1: The raw material solution is injected into the reaction tank through the liquid inlet of the reaction tank; Step 2: The high-temperature jacket layer, transition jacket layer, and low-temperature jacket layer in the multi-section temperature control jacket assembly are started to control the temperature of the solution in the reaction tank; Step 3: The stirring motor is started and operates at a speed of 100 rpm to stir the raw material solution; Step 4: The spray is turned on, the flow rate of the spray nozzle is controlled at 5 ml / min, the spray pressure is 0.2 Mpa, the droplet diameter is less than 50 μm, and at the same time, the stirring motor is always in working state during the spraying process; Step 5: The vacuum pump is started, first pumped to 0.09 MPa, maintained for 10 min, then pumped to 0.05 MPa, and then a small amount of sterile air is injected to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and transition jacket layer, and lower the low-temperature jacket layer to 20℃ at a speed of 0.5℃ per minute to achieve rapid crystallization; Step 7: The reaction in the tank is observed through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed, then recover the lactose from the liquid outlet. If the reaction is slow, increase the flow rate and pressure of the spray to make it react quickly until the reaction is complete; Step 8: After the above reaction is completed, all devices are closed, and the tank is cleaned.
[0031] Example Three On the basis of Example One, a method for using a spray crystallization reaction tank to generate porous anhydrous lactose morphology by recrystallization, comprising the following steps: Step 1: The raw material solution is injected into the reaction tank through the liquid inlet of the reaction tank; Step 2: The high-temperature jacket layer, transition jacket layer, and low-temperature jacket layer in the multi-section temperature control jacket assembly are started to control the temperature of the solution in the reaction tank; Step 3: The stirring motor is started and operates at a speed of 200 rpm to stir the raw material solution; Step 4: The spray is turned on, the flow rate of the spray nozzle is controlled at 20 ml / min, the spray pressure is 0.4 Mpa, the droplet diameter is less than 50 μm, and at the same time, the stirring motor is always in working state during the spraying process; Step 5: Start the vacuum pump, first to 0.09 MPa, maintain 15 min, then to 0.06 MPa, then inject a small amount of sterile air to prevent crystal deposition; Step 6: Stop the temperature supply to the high-temperature jacket layer and the transition jacket layer, and lower the low-temperature jacket layer to 20℃ at a speed of 1℃ per minute, so that rapid crystallization can be achieved; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed, and then recover the lactose from the liquid outlet. If the reaction is slow, increase the flow and pressure of the spray to make it react quickly until the reaction is complete. Step 8: After the above reaction is completed, close all devices and clean the tank.
[0032] It should be noted that similar reference numerals and letters refer to similar items in the following drawings, and therefore, once an item is defined in one drawing, it need not be further defined and explained in subsequent drawings.
[0033] In the description of the present application, it should be noted that the terms "vertical", "horizontal", "inner", "outer", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship commonly used when the product of the present application is used, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.
[0034] In addition, the terms "horizontal", "vertical", etc. do not mean that the components must be absolutely horizontal or vertical, but can be slightly inclined. For example, "horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined.
[0035] In the description of the present application, it should also be noted that, unless otherwise explicitly specified and limited, the terms "provided", "mounted", "connected", "connected" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication between two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.
[0036] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application. It should be pointed out that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present application, and these improvements and modifications should also be considered as falling within the protection scope of the present application.
Claims
1. A spray crystallization reactor for recrystallizing porous anhydrous lactose, characterized in that: The invention comprises a tank support (1), wherein the tank support (1) is connected to a reaction tank (2), and the reaction tank (2) is connected to a multi-stage temperature control jacket assembly (3), and the tank support (1) located at the lower end of the reaction tank (2) is connected to a stirring motor (4), and the driving shaft of the stirring motor (4) is connected to a driving gear (5), and a stirring shaft (6) is connected to the bottom center axis of the reaction tank (2), and the stirring shaft (6) located outside the reaction tank (2) is connected to a driven gear (7), and the driven gear (7) is meshed with the driving gear (5), and the stirring shaft (6) located inside the reaction tank (2) is connected to a stirring connecting rod (8), and the stirring connecting rod (8) is connected to a stirring rod (9), and the stirring rod (9) is connected to the stirring connecting rod. The mixing connecting rod (8) forms a U-shaped structure. The top of the reaction tank (2) is connected to a detachable tank cover (11). The tank cover (11) is connected to a spray pipe (12). One end of the spray pipe (12) extending into the reaction tank (2) is connected to a diverter disk (13) for uniformly spraying into the tank body. The diverter disk (13) is provided with a plurality of liquid flow holes. A spray pipe (14) matching the number of liquid flow holes is arranged in a circumferential array at the bottom of the diverter disk (13). The spray pipe (14) is provided with a plurality of equidistant spray ports, and the direction of the spray ports is set downward. The tank cover (11) is connected to a vacuum pipe (15), and the vacuum pipe (15) is connected to a vacuum pump (16) through a micro-pressure air inlet valve.
2. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 1, characterized in that: The multi-stage control jacket assembly (3) includes a high-temperature jacket layer (31), a transition jacket layer (32) and a low-temperature jacket layer (33). The high-temperature jacket layer (31), the transition jacket layer (32) and the low-temperature jacket layer (33) are mounted on the reaction tank (2) from top to bottom. The high-temperature jacket layer (31) is connected to a high-temperature water tank (35) via a high-temperature circulation pump (34), the transition jacket layer (32) is connected to a transition water tank (37) via a transition circulation pump (36), and the low-temperature jacket layer (33) is connected to a low-temperature water tank (39) via a low-temperature circulation pump (38). The temperature of the high-temperature jacket layer (31) is between 50°C and 85°C, the temperature of the transition jacket layer (32) is between 30°C and 50°C, and the temperature of the low-temperature jacket layer (33) is between 20°C and 30°C.
3. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 2, characterized in that: A heat insulation layer (310) is connected between the high-temperature jacket layer (31) and the transition jacket layer (32), and a heat insulation layer (310) is connected between the transition jacket layer (32) and the low-temperature jacket layer (33).
4. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 1, characterized in that: The stirring connecting rods (8) are provided with six, and each stirring connecting rod (8) is connected to a plurality of stirring rods (9), and the plurality of stirring rods (9) are sequentially spaced from the outside of the stirring connecting rod (8) toward the stirring shaft.
5. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 4, characterized in that: The position of the stirring rod on each stirring connecting rod (8) is staggered with the position of the stirring rod on the adjacent stirring connecting rod.
6. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 4, characterized in that: The end of the stirring connecting rod (8) is connected to a scraper (10) for removing crystal residues on the inner wall of the reaction tank.
7. The spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 1, characterized in that: The angle of the spray port ranges from 45° to 90°, and is arranged to decrease from the outside to the inside of the spray pipe (14).
8. A method for using a spray crystallization reactor for recrystallizing porous anhydrous lactose. It is characterized by: The following steps are involved: Step 1: inject the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: The high-temperature jacket layer, transition jacket layer and low-temperature jacket layer in the multi-stage temperature control jacket assembly are started to control the temperature of the solution in the reaction tank; Step 3: Start the stirring motor and run it at a speed of 100-200 rpm to stir the raw material solution; Step 4: Turn on the spray, control the flow rate of the spray nozzle at 5~20ml / min, the spray pressure at 0.2~.04Mpa, and the droplet diameter is less than 50μm. At the same time, the stirring motor is always in working state during the spraying process; Step 5: Turn on the vacuum pump, first pump to 0.09MPa, maintain for 10-15 minutes, then pump to 0.05-0.06MPa, and then inject a small amount of sterile air to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and the transition jacket layer, and reduce the temperature of the low-temperature jacket layer to 20°C at a rate of 0.5-1°C per minute to enable rapid crystallization; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed and recover the lactose from the liquid outlet. If the reaction is slow, increase the injection flow rate and pressure to make it react quickly until the reaction is complete. Step 8: After the above reaction is completed, turn off all devices and clean the tank.
9. The method for using the spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 8, It is characterized by: The following steps are involved: Step 1: inject the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: The high-temperature jacket layer, transition jacket layer and low-temperature jacket layer in the multi-stage temperature control jacket assembly are started to control the temperature of the solution in the reaction tank; Step 3: Start the stirring motor and run it at 100 rpm to stir the raw material solution; Step 4: Turn on the spray, the flow rate of the spray nozzle is controlled at 5ml / min, the spray pressure is 0.2Mpa, and the droplet diameter is less than 50μm. At the same time, the stirring motor is always in working state during the spraying process; Step 5: Turn on the vacuum pump, first pump to 0.09MPa, maintain for 10 minutes and then pump to 0.05MPa, then inject a small amount of sterile air to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and the transition jacket layer, and reduce the temperature of the low-temperature jacket layer to 20°C at a rate of 0.5°C per minute to enable rapid crystallization; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed and recover the lactose from the liquid outlet. If the reaction is slow, increase the injection flow rate and pressure to make it react quickly until the reaction is complete. Step 8: After the above reaction is completed, turn off all devices and clean the tank.
10. The method for using the spray crystallization reaction tank for recrystallizing porous anhydrous lactose according to claim 8, It is characterized by: The following steps are involved: Step 1: inject the raw material solution into the reaction tank through the liquid inlet of the reaction tank; Step 2: The high-temperature jacket layer, transition jacket layer and low-temperature jacket layer in the multi-stage temperature control jacket assembly are started to control the temperature of the solution in the reaction tank; Step 3: Start the stirring motor and run it at a speed of 200 rpm to stir the raw material solution; Step 4: Turn on the spray, the flow rate of the spray nozzle is controlled at 20ml / min, the spray pressure is at 0.4Mpa, and the droplet diameter is less than 50μm. At the same time, the stirring motor is always in working state during the spraying process; Step 5: Turn on the vacuum pump, first pump to 0.09 MPa, maintain for 15 minutes and then pump to 0.06 MPa, then inject a small amount of sterile air to prevent crystal deposition; Step 6: Stop supplying temperature to the high-temperature jacket layer and the transition jacket layer, and reduce the temperature of the low-temperature jacket layer to 20°C at a rate of 1°C per minute to enable rapid crystallization; Step 7: Observe the reaction in the tank through the window of the reaction tank. If the reaction is normal, wait until the reaction is completed and recover the lactose from the liquid outlet. If the reaction is slow, increase the injection flow rate and pressure to make it react quickly until the reaction is complete. Step 8: After the above reaction is completed, turn off all devices and clean the tank.