Composition with moisturizing and pore shrinking functions and application of composition in cosmetics
The combination of epigallocatechin gallate, sodium N-hyaluronoyl glutamate and fucosyllactose solves the problem of gently tightening pores, achieves the effects of moisturizing and collagen regeneration, and improves the health of the skin.
Patent Information
- Application Number
- CN202510999385.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-21
- Publication Date
- 2025-10-17
AI Technical Summary
Existing technologies make it difficult to gently and effectively tighten pores while maintaining skin moisturizing effects, and methods such as acid peeling can easily cause skin deterioration.
It uses a combination of epigallocatechin gallate (EGCG), sodium N-hyaluroyl glutamate and fucosyllactose to activate fibroblast activity, promote collagen production, enhance epidermal barrier function, reduce water loss, and achieve the effect of moisturizing and tightening pores.
It achieves gentle and effective pore tightening, while improving skin moisturizing effect, promoting collagen regeneration and enhancing skin elasticity.
Smart Images
Figure CN120788929A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of cosmetics, in particular to a composition with moisturizing and pore-contracting effects and its application in cosmetics. BACKGROUND
[0002] According to data, different age groups of Chinese skin have different problems of coarse pores. The skin of 18-30-year-old consumers is often coarse due to excessive oil secretion, and the skin appears "strawberry nose" and "orange peel face", which is easy to block powder and uneven powder when making up, resulting in being labeled as "poor skin quality" and "not delicate", thereby affecting the self-confidence of young consumers. The skin of consumers over 35 years old has collagen loss type coarse pores; after 35 years old, the activity of fibroblasts decreases, the synthesis speed of collagen is less than the degradation speed, and the dermis layer gradually thins and relaxes. The collagen fibers around the pores break or atrophy, like "foundation collapse", the pores lose support and are "lengthened and enlarged", forming elliptical or water droplet-shaped pores. The decrease in skin elasticity caused by collagen loss and the collapse of the support structure around the pores will exacerbate the coarse pores; and the oxidation of oil and inflammatory response accompanying coarse pores will accelerate collagen degradation.
[0003] Therefore, it is a problem that consumers hope to solve to contract the pores, and the current market solutions are mostly to solve the problem by brushing acid, but acid stimulation can easily lead to contracted pores and poor skin, so it is urgent to solve the problem of mild and effective pore contraction. SUMMARY
[0004] The present application aims to overcome the shortcomings of the prior art and provide a composition with moisturizing and pore-contracting effects and its application in cosmetics.
[0005] The present application selects epigallocatechin gallate (EGCG), N-sodium hyaluronate glutamate and fucosyl lactose to achieve effective moisturizing and pore contraction.
[0006] Epigallocatechin gallate (EGCG) can directly neutralize superoxide anions and hydroxyl radicals generated by factors such as ultraviolet rays and pollution, reduce the damage of free radicals to collagen and elastic fibers in the dermis layer, block the expression of MMP-1 (matrix metalloproteinase-1), which is the "key culprit" leading to collagen degradation, and achieve the effect of fine lines and wrinkles. EGCG can indirectly promote the production of type I collagen by activating the activity of fibroblasts.
[0007] N-sodium hyaluronate glutamate is a derivative of hyaluronic acid (HA), which is obtained by grafting glutamic acid onto the molecular chain of hyaluronic acid through chemical modification to form a "hyaluronic acid-amino acid" conjugated structure. The amino group on the surface of the molecule forms a hydrogen bond with the lipid in the stratum corneum, reducing the loss of water through the epidermis, and the immediate moisturizing effect is better than that of ordinary hyaluronic acid.
[0008] Fucosyllactose is a naturally occurring human milk oligosaccharide and one of the functional sugar molecules with high content in human milk. Its chemical structure is formed by fucose, galactose and glucose connected by glycosidic bond. It promotes the synthesis of tight junction proteins between keratinocytes, enhances the function of epidermal barrier and reduces water loss.
[0009] To achieve the above-mentioned purpose, the technical scheme adopted is:
[0010] In a first aspect, the present application provides a composition for moisturizing and shrinking pores, which is composed of the following raw materials in parts by weight: epigallocatechin gallate (EGCG) 0.8-1.5 parts, fucosyllactose 0.8-1.2 parts and N-sodium hyaluronate 0.15-0.2 parts.
[0011] The present application utilizes the combination of epigallocatechin gallate, fucosyllactose and N-sodium hyaluronate, which has a triple effect of "three-dimensional moisturizing-pore shrinking-collagen regeneration". The combination of the three has a synergistic effect, and only the combination of these three specific ingredients can have better moisturizing and pore shrinking effect. Replacing them with other similar substances (tea polyphenols, hydroxypropyl dextran, sodium hyaluronate) will reduce the corresponding effect. At the same time, the composition of the present application can only have better effect within a specific content range, and the moisturizing and pore shrinking effect will decrease beyond the range.
[0012] As a preferred embodiment of the composition of the present application, the composition is composed of the following raw materials in parts by weight: epigallocatechin gallate (EGCG) 1 part, fucosyllactose 1 part and N-sodium hyaluronate 0.15 part. At this content, the composition has better moisturizing and pore shrinking effect.
[0013] In a second aspect, the present application provides the use of the above-mentioned composition in the preparation of cosmetics.
[0014] As a preferred embodiment of the use of the present application, the cosmetics include cosmetic water, cream, sunscreen, mask, makeup, cleansing product, etc.
[0015] In a third aspect, the present application provides a cosmetic product comprising the above-mentioned composition.
[0016] As a preferred embodiment of the cosmetic product of the present application, the cosmetic product further comprises an auxiliary material.
[0017] In a fourth aspect, the present application provides a toner, which comprises the above-mentioned composition 1.75-2.9%, auxiliary material 7-22% and water in balance in percentage by weight. Preferably, the water is deionized water.
[0018] As a preferred embodiment of the toner of the present application, the toner comprises epigallocatechin gallate (EGCG) 0.8-1.5%, fuculose lactose 0.8-1.2%, N-transparency glutamate sodium 0.15-0.2%, adjuvant 7-22% and water in balance by weight percentage.
[0019] As a preferred embodiment of the toner of the present application, the toner comprises epigallocatechin gallate (EGCG) 1%, fuculose lactose 1% and N-transparency glutamate sodium 0.15%, adjuvant 16% and water in balance by weight percentage.
[0020] As a preferred embodiment of the toner of the present application, the adjuvant comprises one or both of a solvent or a humectant.
[0021] As a preferred embodiment of the toner of the present application, the solvent comprises one or both of butylene glycol or 1,3-propanediol; and the humectant comprises one or more of isopentyldiol, glycerol, methylgluceth-20, PPG-13-decyltetradecinol polyether-24 or 1,2-pentanediol.
[0022] As a preferred embodiment of the toner of the present application, the toner comprises the above composition 1.75-2.9%, solvent 3-10%, humectant 4-12% and water in balance by weight percentage.
[0023] As a preferred embodiment of the toner of the present application, the toner comprises epigallocatechin gallate (EGCG) 0.8-1.5%, fuculose lactose 0.8-1.2%, N-transparency glutamate sodium 0.15-0.2%, solvent 3-10%, humectant 4-12% and water in balance by weight percentage.
[0024] As a preferred embodiment of the toner of the present application, the toner comprises epigallocatechin gallate (EGCG) 1%, fuculose lactose 1% and N-transparency glutamate sodium 0.15%, solvent 7%, humectant 9% and water in balance by weight percentage.
[0025] In a fifth aspect, the present application provides a preparation method of the above-mentioned toner, comprising the following steps:
[0026] S1, respectively adding epigallocatechin gallate (EGCG) and fuculose lactose in the composition into a solvent, and fully dissolving to obtain an epigallocatechin gallate (EGCG) solution and a fuculose lactose solution;
[0027] S2, heating water, adding a humectant, mixing, adding the epigallocatechin gallate (EGCG) solution and the fucosyl lactose solution of step S1, mixing, adjusting the pH value to 5.5-6.5, adding N-sodium carboxymethyl hyaluronate in the composition, dissolving thoroughly, cooling to room temperature, homogenizing, filtering, and obtaining the toner.
[0028] The polyhydric alcohol can buffer partial acid-base change, and butanediol can stabilize the structure of EGCG in an acidic system (pH<5), while EGCG is easy to be ineffective due to acidic hydrolysis when dissolved in water alone. The carboxylic acid group (-COOH) and the amide group (-CONH-) of N-sodium carboxymethyl hyaluronate are sensitive to the pH environment, and will present different dissociation states under different acidities, so the pH needs to be adjusted before adding.
[0029] As a preferred embodiment of the preparation method, in step S1, the solvent corresponding to the EGCG is butanediol, and the solvent corresponding to the fucosyl lactose is 1,3-propanediol. Butanediol can stabilize the structure of EGCG in an acidic system (pH<5), while EGCG is easy to be ineffective due to acidic hydrolysis when dissolved in water alone.
[0030] As a preferred embodiment of the preparation method, in step S1, the dissolving condition is 300 rpm stirring.
[0031] As a preferred embodiment of the preparation method, in step S2, the heating temperature is 60℃, and the mixing and dissolving condition is 400 rpm stirring.
[0032] Compared with the prior art, the present application has the following beneficial effects:
[0033] In the composition of the present application, N-sodium carboxymethyl hyaluronate, as a derivative of hyaluronic acid, has a glutamic acid group similar to the composition of natural moisturizing factors in the stratum corneum, which can promote the synthesis of lipids between keratinocytes and make the stratum corneum arrange more closely; EGCG inhibits the enzyme activity of MMPs and reduces collagen degradation; fucosyl lactose may stimulate fibroblasts to synthesize collagen by regulating the metabolic products of the flora, and the three components synergistically realize the triple action of “three-dimensional moisturizing-pore contraction-collagen regeneration”. BRIEF DESCRIPTION OF DRAWINGS
[0034] Figure 1 The test results of the moisture retention rate of the sample in Test Example 1 of the present application at different time periods;
[0035] Figure 2 The state diagram of the toner 1 in the application example of the present application. DETAILED DESCRIPTION
[0036] In order to better illustrate the purposes, technical solutions and advantages of the present application, the present application will be further described below in combination with specific examples.
[0037] Other materials, reagents, etc. used in the examples can be obtained from commercial channels unless otherwise specified.
[0038] Epigallocatechin gallate (EGCG), powder, purchased from Guangzhou Liyuan Biotechnology Co., Ltd.;
[0039] Fucosyllactose, powder, purchased from Shaanxi Xinpai Biotechnology Co., Ltd.;
[0040] N-acetyl glucosamine, powder, purchased from Zhuoke Biotechnology (Hainan) Co., Ltd.
[0041] The fucosyllactose of the present application is 2' fucosyllactose.
[0042] Examples 1-6, Comparative Examples 1-8
[0043] The components and contents of the compositions of Examples 1-6 and Comparative Examples 1-8 are shown in Table 1 below,
[0044] Table 1
[0045]
[0046]
[0047] Test Example 1
[0048] The moisture retention performance of the solutions of the compositions of Examples 1-6 and Comparative Examples 1-8 was tested, with the solution of the composition obtained by dissolving the composition in water according to the weight fraction in Table 1 (the sum of the weight fraction of the composition and water is 100 parts) as the experimental sample, and 5% glycerol aqueous solution as the positive control sample. The test was performed according to the method 2 weighing bottle method of QTC-C-LAB-TOP-042 "Cosmetic Moisturizing Efficacy In Vitro Test Method (Weighing Method)".
[0049] 1g of sample (accurate to 0.0001g) was weighed using a weighing bottle as a carrier, the mass of the weighing bottle and the mass of the sample were recorded, and the experimental sample and the positive control sample were placed in an environment of (22±2)℃ and humidity (50±10)%, and the mass was weighed and recorded every interval, the moisture retention rate was calculated, and the change curve was drawn.
[0050] The test results of the moisture retention rate of the sample at different time periods are shown in Table 2 and Figure 1 Table 3.
[0051] Table 2
[0052]
[0053] The results of Table 2 show that the compositions of Examples 1-6 have a moisturizing rate of 83.6% to 90.8% in 1h, and the moisturizing rate of Example 2 is the highest, and the moisturizing effect is the best.
[0054] According to the results of Example 2 and Comparative Examples 1-3, the sum of the moisturizing rates of Comparative Examples 1, 2 and 3 is less than that of Example 2, which indicates that the combination of epigallocatechin gallate, fucosyl lactose and N-sodium carboxymethyl glutamate has a synergistic effect.
[0055] According to the results of Example 2 and Comparative Examples 4-6, when the components of the composition of the present application are replaced by other substances with similar effects, such as replacing EGCG with tea polyphenol, or replacing fucosyl lactose with hydroxypropyl dextran, or replacing N-sodium carboxymethyl glutamate with sodium hyaluronate, the moisturizing rate of the corresponding composition is reduced. This indicates that the composition of the present application can only be combined according to specific components.
[0056] According to the results of Example 2 and Comparative Examples 7 and 8, when the content of the components of the composition of the present application exceeds the range of the examples, the moisturizing rate of the corresponding composition is reduced, which indicates that the composition of the present application needs to meet a specific content range.
[0057] Application Example
[0058] A toner, comprising the above composition 1.75-2.9% by weight, adjuvants 7-22% and water in the balance. The adjuvants include one or both of a solvent or a humectant. The solvent includes one or both of butylene glycol or 1,3-propanediol; the humectant includes one or more of isopentyldiol, glycerin, methyl gluceth-20, PPG-13-decaethyltetradecinol ether-24 or 1,2-pentanediol.
[0059] The composition is mixed with adjuvants to prepare a toner, and the toner prepared from the compositions of Examples 1-6 is denoted as toner 1-6, and the toner prepared from the compositions of Comparative Examples 1-6 is denoted as comparative toner 1-6.
[0060] The components and contents of toners 1-8 and comparative toners 1-6 are shown in Table 3 and Table 4 below, and the components and contents of comparative toners 7 and 8 are the same as those of toner 2,
[0061] Table 3
[0062]
[0063] Table 4
[0064]
[0065]
[0066] The preparation method of the toner 1-8, the comparative toner 1-6, comprises the following steps:
[0067] S1, EGCG is added to the solvent butanediol, and stirred at 300 rpm in the dark until completely dissolved to obtain an EGCG solution; fucosyllactose is added to the solvent 1,3-propanediol, and stirred at 300 rpm until clear and completely dissolved to obtain a fucosyllactose solution;
[0068] S2, water is heated to 60℃, then the humectants glycerol, isopentyldiol and 1,2-pentanediol are added, and stirred at 400 rpm until uniform, then the EGCG solution and the fucosyllactose solution of step S1 are added, and continuously stirred until the system is uniform; the pH is slowly adjusted to 5.5-6.5 with a citric acid solution, and N-translucent glutamic acid sodium is added, and stirred until completely dissolved. Cool to room temperature, homogenize, filter, and obtain the toner.
[0069] The preparation method of the comparative toner 7 comprises the following steps:
[0070] Water is heated to 60℃, then the humectants glycerol, isopentyldiol, 1,2-pentanediol, solvent butanediol and 1,3-propanediol are added, and stirred until uniform, then EGCG and fucosyllactose are added, and continuously stirred until the system is uniform. The pH is slowly adjusted to 5.5-6.5 with a citric acid solution, and N-translucent glutamic acid sodium is added, and stirred until completely dissolved. Cool to room temperature, homogenize, filter, and obtain the toner.
[0071] The preparation method of the comparative toner 8 comprises the following steps:
[0072] S1, EGCG is added to the solvent butanediol, and stirred until completely dissolved to obtain an EGCG solution; fucosyllactose is added to the solvent 1,3-propanediol, and stirred until clear and completely dissolved to obtain a fucosyllactose solution;
[0073] S2, water is heated to 60℃, then the humectants glycerol, isopentyldiol and 1,2-pentanediol are added, and stirred until uniform, then the EGCG solution and the fucosyllactose solution of step S1 are added, and continuously stirred until the system is uniform; N-translucent glutamic acid sodium is added, and stirred until completely dissolved. The pH is slowly adjusted to 5.5-6.5 with a citric acid solution, and cool to room temperature, homogenize, filter, and obtain the toner.
[0074] The obtained toners 1-8 have good stability and meet the requirements of cosmetic water. The state diagram of the toner 1 is shown in Figure 2 .
[0075] Test Example 2
[0076] Using the toner 1-8 and the comparative toner 1-8 as samples, human body pore convergence effect test was performed.
[0077] Eighty volunteers were recruited, divided into 16 groups, 5 people in each group, and the screening indicators of the volunteers included: healthy women, 30-60 years old, able to read and understand all the contents of the informed consent, voluntarily signed the informed consent, agreed not to use any cosmetics, drugs and health products that could affect the results during the test period, did not participate in any other clinical trials of other research centers during the test period, and did not participate in other clinical studies in the past month.
[0078] The toner 1-8 and the comparative toner 1-8 were used respectively, and the number of skin pores before and after using the toner was analyzed by taking pictures (three faces with eyes open) using VISIA-CR and using IPP software, the number of pores W0 tested before using the toner, and the number of pores W4 tested after using the toner on the face for 4 weeks. The change rate was calculated according to the number of pores,
[0079] Change rate (%) = (W4-W0) / W0*100.
[0080] Parameter explanation: the smaller the pore number, the fewer the pores (small).
[0081] Result determination: after using the product, the proportion of the number of pores in the test area was significantly reduced, indicating that the test product had the effect of fine pores.
[0082] The results of different toners converging pores are shown in Table 5,
[0083] Table 5
[0084] Test sample Change rate (%) Test sample Change rate (%) Toner 1 -5.13 Comparative toner 1 -0.26 Toner 2 -5.22 Comparative toner 2 0.54 Toner 3 -5.07 Comparative toner 3 0.76 Toner 4 -4.65 Comparative toner 4 -1.24 Toner 5 -4.57 Comparative toner 5 -1.37 Toner 6 -4.21 Comparative toner 6 -1.57 Toner 7 -5.17 Comparative toner 7 -2.19 Toner 8 -5.15 Comparative toner 8 -2.93
[0085] Table 5 shows that the change rate of the toner of the present application on the skin pores is between -5.22% and -4.21% after 4 weeks, indicating that the toner prepared by using the composition of the present application has the effect of converging pores.
[0086] According to the results of the toner 2 and the comparative toner 1-3, the sum of the change rates of the comparative toners 1, 2 and 3 is less than that of the toner 2, indicating that the combination of epigallocatechin gallate, fucosyl lactose and N-translucent glutamate sodium has a synergistic effect.
[0087] According to the results of the toner 2 and the comparative toner 4-6, replacing the composition of the present application with other substances with similar effects reduces the corresponding effect of converging pores. It is indicated that the composition of the present application can only be combined according to specific ingredients.
[0088] Finally, it should be noted that the above examples are merely intended to illustrate the technical solutions of the present application and not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present application.
Claims
1. A composition having moisturizing and astringent pores, characterized in that: The invention is composed of the following raw materials in parts by weight: 0.8-1.5 parts of epigallocatechin gallate, 0.8-1.2 parts of fucosyllactose and 0.15-0.2 parts of sodium N-hyaluronoyl glutamate.
2. Use of the composition according to claim 1 in the preparation of cosmetics.
3. A cosmetic, characterized in that: The invention comprises the composition according to claim 1.
4. A toner, characterized in that: Calculated by weight percentage, the composition comprises 1.75-2.9% of the composition of claim 1, 7-22% of auxiliary materials and the balance of water.
5. The toner according to claim 5, characterized in that The toner comprises 0.8-1.5% of epigallocatechin gallate, 0.8-1.2% of fucosyllactose, 0.15-0.2% of sodium N-hyaluroyl glutamate, 7-22% of auxiliary materials and the balance of water.
6. The toner according to claim 4 or 5, characterized in that The auxiliary materials include one or both of solvents and moisturizers.
7. The toner according to claim 6, characterized in that The solvent includes one or both of butanediol and 1,3-propylene glycol; And / or, the moisturizing agent includes one or more of isopentyl glycol, glycerin, methyl gluceth-20, PPG-13-decyltetradeceth-24 or 1,2-pentanediol.
8. The toner according to claim 6, characterized in that Calculated by weight percentage, the toner comprises 1.75-2.9% of the composition of claim 1, 3-10% of a solvent, 4-12% of a moisturizer and the balance of water.
9. The toner according to claim 8, characterized in that Calculated by weight percentage, the toner comprises 0.8-1.5% of epigallocatechin gallate, 0.8-1.2% of fucosyllactose, 0.15-0.2% of sodium N-hyaluroyl glutamate, 3-10% of solvent, 4-12% of moisturizer and the balance of water.
10. The method for preparing the toner according to claim 8 or 9, characterized in that: The following steps are involved: S1. adding epigallocatechin gallate and fucosyllactose in the composition into a solvent respectively and dissolving them fully to obtain an epigallocatechin gallate solution and a fucosyllactose solution; S2. Heat the water, add the moisturizer, mix well, then add the epigallocatechin gallate solution and the fucosyllactose solution of step S1, and mix well; adjust the pH value to 5.5-6.5, add the sodium N-hyaluroyl glutamate in the composition, and fully dissolve it; cool to room temperature, homogenize, and filter to obtain the toner.