Fixable ejection device for analysis device

Abstract

The present application provides a fixable ejection device for an analysis apparatus, in particular a device (100), in particular a sample handling device for an analysis apparatus (10), the device (100) comprising: i) an object handling device (110), in particular a robotic arm, configured for handling an object, in particular an analysis sample; ii) a needle (150), in particular a sample needle, connected, in particular fixedly connected, to the object handling device (110); iii) a movable element (120), in particular an ejection device, movably connected to the object handling device (110), the movable element (120) being at least partially movable relative to the connected needle (150); and iv) a fixing mechanism (130) configured for fixing the movable element (120) in at least one position.

Description

Technical Field

[0001] The present invention relates to a device, particularly a sample processing device for use in an analytical instrument. The device comprises an object processing device for processing an object, a needle connected to the object processing device, a movable element movably connected to the object processing device, and a fixing mechanism for fixing the movable element in at least one position. Furthermore, the present invention relates to a corresponding method. Background Art

[0002] An analysis device (e.g., a sample separation device) is used to analyze a sample, particularly a fluid sample, for example, to perform chromatographic separation on the sample.

[0003] Exemplarily, in high performance liquid chromatography (HPLC, High Performance Liquid Chromatography) analytical equipment, liquid (mobile phase) moves through so-called stationary phase (for example, in chromatographic column) under the flow velocity (for example, in the range of microliters per minute to milliliters per minute) of very accurate control and high pressure (generally 20bar to 1000bar and above, currently up to 2000bar). In this case, liquid has obvious compressibility, so that each fraction of the sample fluid introduced into mobile phase is separated from each other. After the stationary phase, the separated fraction of the fluid sample is detected in a detector. This HPLC system is known, for example, from EP0309596B1 of same applicant Agilent Technologies, Inc. (Agilent Technologies, Inc.).

[0004] A robotic arm with a sample needle is usually used to introduce the (fluid) sample into such an analytical device. This allows for high automation and high precision. In order to allow the sample needle to be removed smoothly from the sample container (e.g., a sample bottle) (sensitive sample needles may get stuck), a release device is usually used that can reliably release the sample container without the sample container being carried away or lifted by the sample needle. This release device is also called an ejection device or a stripping device. For example, WO 2021 / 171232A1 describes an ejection device.

[0005] In known application scenarios, such (vial) ejection devices can be used passively (without their own drive, e.g., spring-loaded) or actively (with their own drive). For example, a passive ejection device can only be deflected by driving the associated robotic arm in the vertical direction (Z axis). In contrast, an active ejection device has its own drive and can be positioned and held at any position along the travel path. Thus, when using an active ejection device, additional functions can be implemented using robotics. However, the disadvantage of an active ejection device is the additional cost and space required for the drive device. Summary of the Invention

[0006] There may be a need for efficient, cost-effective, and flexible use of sample processing devices of analytical instruments.

[0007] This problem is solved by the independent claim. Further embodiments are given by the dependent claims.

[0008] According to an exemplary embodiment of the present invention, a device is described, in particular a sample processing device for an analytical device (e.g., HPLC), comprising:

[0009] i) an object handling device (e.g., a robotic arm) for handling (transporting, moving, and taking / putting down samples) objects, in particular for analyzing (fluid) samples;

[0010] ii) a needle (sample needle), which is connected to the object processing device (in particular firmly connected or fixed);

[0011] iii) a movable element (in particular an ejection device) which is movably connected to the object handling device (in particular has a return mechanism), wherein the movable element is at least partially movable relative to the (fixedly) connected needle;

[0012] iv) (releasable) fixing means (eg magnets etc.) for fixing the movable element in at least one position (in particular for releasing the fixing again).

[0013] According to an exemplary embodiment of the present invention, a method is described, the method comprising:

[0014] i) (movably) connecting the movable element, in particular the ejection device, to an object handling device connected to the needle, whereby the movable element is at least partially movable relative to the connected needle; and,

[0015] ii) (reversibly) fixing the movable element in at least one position.

[0016] According to an exemplary embodiment of the present invention, a sampler (or a sampler or a sample chamber) for an analytical device is described, wherein the sampler has the above-mentioned device.

[0017] According to an exemplary embodiment of the present invention, an analytical device (eg HPLC) for carrying out an analytical method (eg sample separation in a chromatographic column) is described, wherein the analytical device has a device or a sampler as described above.

[0018] In the present application, the term "sample processing device" is particularly understood to mean a device suitable for processing (fluid) samples and / or sample containers (for storing fluid samples). Such a sample processing device can be installed in a sampler (sampler) of an analytical device. The sample processing device may include a drive device (e.g., a motor) for moving the object processing device in one or more spatial directions. In particular, the object processing device can be configured to move in a vertical direction to pick up a sample and put it down again (via a sample needle) after transport.

[0019] In the present application, the term "movable element" particularly refers to a part of a (sample processing) device, which is movable relative to the object processing device and, accordingly, is also movable relative to the needle. Preferably, the movable element is a passive element, which is only moved indirectly by the movement of the object processing device (and does not have its own motor). In one embodiment, the movable element is realized as an ejection device. In particular, the ejection device is movable relative to the (fixed) needle (and independently of the needle). In one embodiment, a part of the ejection device is at least partially arranged around the needle to peel off the sample container (from which the needle removes the sample). In another embodiment, the ejection device has a return mechanism (e.g. a spring) to move the ejection device back to the starting point (e.g. by a beam connected to the spring).

[0020] In the present application, the term "drive means" or "driver" relates in particular to a device for providing a driving force to the object handling device or the movable element. Exemplarily, the drive means may be configured for moving a robotic arm in the sampler. In particular, the drive means may be configured to move the robotic arm in a vertical direction (upwards and downwards). In a preferred embodiment, the driving force may increase when the object handling device (in particular a part of the movable element) presses on the object (preferably a part of the movable element presses on a surface). Exemplarily, the drive means may comprise a motor, for example an electric motor.

[0021] In the present application, the term "fixing mechanism" particularly relates to an element, device or function for fixing a movable element in a specific position or releasing the fixation again. For example, in order to fix, a retaining force can be applied to the movable element (a part) so that the movable element is fixed in an appropriate position (the desired position). In one embodiment, the fixation is a releasable and reversible connection. In one embodiment, the fixing mechanism can be configured to have only two states (bistable): holding and not holding. Exemplarily, such a fixing mechanism can be provided with a magnet, which applies a releasable retaining force to the movable element at a specific desired position.

[0022] In a preferred embodiment, the securing mechanism can secure and release the securement, which can be the same mechanism (eg, push-push) or a different mechanism (eg, stick-peel).

[0023] In the present application, the term "fluid" may be understood to mean, in particular, a liquid and / or a gas, optionally including solid particles. The term "fluid sample" may be understood to mean, in particular, a medium containing a material to be analyzed (e.g., a biological sample), in particular a liquid, such as a protein solution, a pharmaceutical sample, etc.

[0024] In the present application, "mobile phase" can be understood to mean in particular a fluid, in particular a liquid. This fluid is a carrier medium that transports a fluid sample between a fluid-driven and a sample separation device. Mobile phase can also be used for a fluid transport device to influence the fluid sample. For example, the mobile phase can be a solvent (e.g., an organic and / or inorganic solvent) or a solvent combination (e.g., water and ethanol).

[0025] In the present application, the term "analytical device" refers in particular to a device that can be used to analyze a fluid sample, in particular to separate it, more particularly to separate it into different fractions. For example, such sample separation can be achieved by chromatography or electrophoresis. Preferably, the analytical device can be a liquid chromatography sample separation device.

[0026] In this application, the term "sample needle" may be understood to mean, in particular, a hollow body having an inner cavity or through-hole through which a fluid sample can pass. In particular, the fluid sample can be introduced into (e.g., aspirated) and / or removed from (e.g., ejected) the sample processing device through the inner cavity or through-hole. The sample needle may be elongated and rotationally symmetrical, and thus may have an axis of symmetry.

[0027] According to exemplary embodiments, the present invention may be based on the idea of ​​enabling efficient, cost-effective, and flexible use of a sample handling device of an analytical instrument by securing a movable element (which is movable relative to an object handling device (robot arm) and a needle connected thereto) in one or more (desired) positions by means of a securing mechanism, particularly when the movable element is passive or lacks its own drive. In other words, if a passive ejection device is locked in one or more positions, the same possibilities and advantages as an active ejection device with its own drive are achieved, but without the need for an additional drive and the associated expense.

[0028] Exemplarily, the mechanical locking of the ejection device can be triggered or released again by moving to a specific position within the sampler chamber (using a robotic arm). For example, the locking can be implemented as a push-push mechanism, a magnetic mechanism or by a lever mechanism and can be triggered in any axis of motion. In one example, the locking / tightening is triggered by movement in the rotation axis of the robotic arm, but can also be triggered by movement in the Z axis.

[0029] In an exemplary embodiment, the ejection device can be fixed in a fixed axial position relative to the needle. Preferably, no active element, such as a drive device, is used, resulting in a completely "passive" movement of the ejection device. According to the present invention, a mechanism can be provided for locking the axial position of the ejection device in at least one axial position. Exemplarily, this axial position differs from the initial position, allowing the needle to protrude from the ejection device. This can facilitate specific functions of the ejection device and / or the needle.

[0030] Exemplary embodiments

[0031] In one embodiment, the movable element is a passive element. In particular, the passive element lacks a drive, particularly a motor. In one embodiment, the fixing mechanism is a passive mechanism. In particular, the passive mechanism lacks a drive. In one embodiment of the method, the movement of the movable element is independent of the drive. In one embodiment of the method, the fixing is performed independent of the drive. This saves cost, space, and effort.

[0032] In this application, the term "passive device" is particularly understood to mean a device that is configured to secure / release a movable element (e.g., an ejection device) without an active drive or a (direct) connection to an active drive. In particular, the device does not have such a drive or such a drive connection, or is completely devoid of such a drive or drive connection. The term "drive" may refer to a device capable of providing a physical force, in particular a mechanical force. Preferably, the drive may be an electric motor.

[0033] In one embodiment, the at least one fixed position of the movable element includes at least one of the following: a source position, an initial position, an end position, and a needle exposure position. Different positions may be particularly useful for different applications. In this way, the flexibility of use of the sample processing device can be significantly improved. For example, fixing in the initial position can achieve efficient calibration (see Figures 3A to 3D In another example, the exposure of the sample needle can enable interesting applications, such as transporting a sample container using the sample needle.

[0034] In one embodiment, the securing mechanism is configured to secure (and release) the movable element in two or more positions. This allows for particularly flexible and efficient operation of the sample processing device. In one embodiment, stepwise or stepless switching between two or more positions is possible. Depending on the design of the securing mechanism, multiple defined securing positions can be provided, or stepless securing can be achieved, thereby enabling fine-tuning.

[0035] In one embodiment, the fixing mechanism has at least one of the following: snapping in, popping out, retracting, extending, pushing in, pushing out, inserting, pulling out, adhering, separating, clamping, releasing, deflecting, returning, a push-push mechanism, a lever mechanism, utilizing magnetic attraction, utilizing electromagnetic attraction.

[0036] These are just some examples, and there are many possible ways to achieve efficient and reliable securing (and release of the securing).

[0037] Of particular note here is the distinction between triggering / activating a fixation and its reverse operation (i.e., releasing the fixation). Both can use the same mechanism (e.g., push-push), but this need not be the case. For example, one can distinguish between i) fixation by adhesion (e.g., Velcro) or suction (e.g., magnets), and ii) release by tension or pressure. In other words, fixation and release can be the same mechanism or different mechanisms.

[0038] In one embodiment, a detent position can be provided (e.g., on a robotic arm or object handling device). In one embodiment, the securing pin can be pushed in (and pulled out again). In one embodiment, the securing mechanism can be electrically activated, e.g., by an electromagnet. In one embodiment, a portion of the movable element can be retracted (and extended again) into the securing position.

[0039] In one embodiment, the fixing mechanism comprises a fixing element, in particular comprising at least one of the following: a magnet, an electromagnet, a spring, a snap, a suction cup, a hook and loop fastener, a reusable adhesive, a friction fit, a fixing pin, a hook, a latch, a Velcro.

[0040] These are just some examples, and there are many possible ways to achieve efficient and reliable fixation (and release of the fixation) using the fixing element. For example, fixation is achieved by a holding force H, and release is achieved by a pressure Z opposite to the holding force H, which is Figure 2A and Figures 3A to 3D Furthermore, a plurality of fixing elements may be provided (eg, stacked in a vertical direction) to provide a plurality of fixing positions.

[0041] In one embodiment, the device comprises a positioning element which predetermines one or more positions for fixing the movable element, in particular in the vertical direction. This can have the advantage that two or more fixed positions connected to each other can be provided. These positions can be arranged stepwise or steplessly. In one example, a plurality of magnets can be stacked in a vertical direction, each magnet representing a fixed position. Exemplarily, at the position to be fixed, the corresponding magnet can be moved towards the movable element to establish the fixation (see Figure 2B ). To release the fixation, the magnet can be moved away from the movable element again. In another example, the magnet can be moved in the vertical direction, thus achieving stepless fixation.

[0042] In one embodiment, the securing mechanism can be triggered (and released again) by at least one of the following: automatically, manually, manually, by a control device, mechanically, electrically, pneumatically, or hydraulically. These are just some examples; many implementations are possible, and the specific choice can depend on the desired application.

[0043] In one embodiment, the movable element comprises an ejection device or (sample container) stripping device (see above definition). In one embodiment, the ejection device comprises a guide structure that is at least partially arranged around the needle. This reliably protects the sensitive needle. In one example, in the initial position, the needle is not exposed and is surrounded by the guide structure (at least partially, for example, a rod-shaped element).

[0044] In one embodiment, the ejection device (or guide structure) comprises an end element having an opening through which the needle can be guided (in an aligned manner). Thus, the needle can be quickly and efficiently exposed when in use (eg for sampling).

[0045] In one embodiment, the needle is at least partially exposed in at least one fixed position of the movable element. Figure 2B It is clearly stated in the figure: the movable element is deflected and the needle is guided through the opening of the movable element and exposed. In this position, the movable element can be fixed to keep the needle exposed.

[0046] In one embodiment, the device is configured so that the at least partially exposed needle can be used to transport objects, in particular sample containers and / or filter elements. For this special application, the disadvantage of sample extraction can be turned into an advantage: without a push-out device to peel off the sample container, the sample needle is likely to be "stuck" in the sample container. But interestingly, this situation is conducive to transporting the sample container with the help of the needle. In this way, an additional clamping device (claws) for transporting the sample container becomes redundant. In addition, this application can overcome the problem of sample residue. In one example, the corresponding sample container can be designed without a septum. In another application, the (exposed) sample needle can be used to squeeze the (contaminated) sample through the filter.

[0047] In one embodiment, the movable element is movably connected to the object handling device via an elastic element (particularly a spring element). The elastic element can provide a restoring force to return the movable device to its initial position after deflection. This eliminates the need for an active drive device for the ejection device.

[0048] In one embodiment, the movable element is configured to return to the source position after each movement (or deflection). In one embodiment, the elastic element is configured to always return the movable element to the source position. For example, this can be achieved by the above-mentioned spring element.

[0049] In one embodiment, the guide structure is connected to the lever element. In one embodiment, the lever element is connected to the elastic element. In this way, deflection or resetting can be achieved efficiently and reliably.

[0050] In one embodiment, the object handling device is configured to move the needle to at least one of the following positions: a starting position, a sample container, a sampling position, a needle holder, a needle cleaning device, and a sample injection point. Thus, the (sample handling) device can directly perform important functions associated with the analytical device. Each of these applications can serve as an object to be pressed by the device.

[0051] In one embodiment, the sample container comprises at least one of the following: a vial, a bottle, a sample bottle, a sample tube, a micro reaction container, a (micro) well plate, a deep well plate. In one example, the sample container can be any device suitable for directly or indirectly storing a (fluid) sample.

[0052] In one embodiment, the object handling device is configured as a robotic arm, and in particular, a driving device is provided at the end of the robotic arm. Robotic arms with corresponding configurations have been used in the field of samplers, and thus can be implemented in a simple manner.

[0053] In one embodiment, the device is configured as at least one of the following: a sample processing device, a dispensing device, a pipetting device, an injection device, a transport device, in particular for transporting sample containers. In this way, the described invention can be directly applied to a variety of technically and economically important applications.

[0054] In one embodiment, the fixed position can be located at approximately one-quarter, one-half, or three-quarters of the deflection of the movable element. For example, the distance from the initial position can be 10 mm or more, in particular 25 mm or more. In one embodiment, there are two or more, in particular three or more, and further in particular five or more fixed positions.

[0055] According to one embodiment, the analytical device is configured as a sample separation device. According to one embodiment, the analytical device includes a fluid driver for driving a mobile phase and a fluid sample injected into the mobile phase. According to one embodiment, the analytical device includes a sample separation device for separating the fluid sample injected into the mobile phase. According to one embodiment, the analytical device is configured to analyze at least one physical, chemical, and / or biological parameter of the fluid sample. According to one embodiment, the analytical device is configured as a sample separation device for separating a fluid sample.

[0056] In this application, the term "sample separation device" may be understood to refer in particular to a device for analyzing a fluid sample (in particular, separating it into different fractions). To this end, components of the fluid sample may be initially adsorbed on the sample separation device and then desorbed individually (in particular, in stages). For example, such a sample separation device may be configured as a chromatographic separation column.

[0057] According to one embodiment, the analysis device may be a chromatograph, in particular a liquid chromatograph, a gas chromatograph, a supercritical fluid chromatograph (SFC) or a high performance liquid chromatograph HPLC.

[0058] According to one embodiment, the analysis device is configured as a microfluidic device. According to one embodiment, the analysis device is configured as a nanofluidic device.

[0059] According to one embodiment, the sample separation device is configured as a chromatographic separation device, in particular as a chromatographic separation column.

[0060] According to one embodiment, the fluid drive is configured to drive the mobile phase and the fluid sample at high pressure.

[0061] According to one embodiment, the fluid drive is configured to drive the mobile phase and the fluid sample at a pressure of at least 500 Bar, in particular at least 1000 Bar, further in particular at least 1200 Bar.

[0062] According to one embodiment, the analysis device comprises a detector for detecting the analyzed fluid sample, in particular the separated fluid sample.

[0063] According to one embodiment, the analytical device comprises a fractionator for fractionating the fluid sample into separated fractions.

[0064] The analytical device can be a microfluidic measurement device, a life science device, a liquid chromatograph, a gas chromatograph, a high-performance liquid chromatograph (HPLC), an ultra-high-performance liquid chromatograph (UHPLC), or a supercritical fluid chromatograph (SFC). Of course, many other applications are also possible.

[0065] According to one embodiment, the sample separation device can be configured as a chromatographic separation device, particularly a chromatographic separation column. In chromatographic separation, the chromatographic separation column can be provided with an adsorption medium. A fluid sample can be adsorbed thereon and then desorbed in stages in the presence of a specific solvent combination, thereby achieving separation of sample fractions.

[0066] Illustratively, a pump system for delivering fluids may be configured to deliver fluids or mobile phases through the system at high pressures ranging from a few hundred Bar to 1000 Bar and above.

[0067] The analytical device may include a sample injector for introducing a sample into a fluid separation path. This sample injector may include a sample needle or injection needle that can be connected to a needle holder in the corresponding fluid path. The sample needle can be extended from the needle holder to obtain a sample. After reinserting the sample needle into the needle holder, the sample can be located in the fluid path, which can be connected to the system's separation path via a switching valve. In another embodiment of the present invention, a sample injector or sampler with a sample needle without a needle holder can be used.

[0068] According to one embodiment, the needle device can include a sample holding volume, in particular a sample loop, in fluid connection with the sample needle. This can be understood to be a capillary section, the interior of which forms a holding volume for holding a certain amount of fluid sample.

[0069] The analytical equipment may include a fractionation collector for collecting separated components. This fractionation collector can direct the separated different sample components into different liquid containers. The analyzed samples can also be directed to a waste container.

[0070] Preferably, the analytical device may include a detector for detecting the separated components. Such a detector may generate a signal that can be observed and / or recorded and indicates the presence and amount of the sample components in the fluid flowing through the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0071] Other objects and many attendant advantages of the embodiments of the present invention will be readily understood and better appreciated with reference to the following more detailed description of the embodiments of the present invention in conjunction with the accompanying drawings. Features that are substantially or functionally the same or similar are denoted by the same reference numerals.

[0072] Figure 1 An analysis device according to an embodiment of the present application is shown.

[0073] Figure 2A and 2B Each shows a sample processing device according to an embodiment of the present application.

[0074] Figures 3A to 3D The use of the sample processing device according to an embodiment of the present application is shown. DETAILED DESCRIPTION

[0075] The attached figure is a schematic diagram.

[0076] Figure 1 The basic structure of an HPLC system is shown as an example of an analytical device 10 according to an exemplary embodiment of the present invention, which is configured as a sample separation device, such as for use in liquid chromatography. A fluid transporter or fluid driver 20 is supplied with a solvent by a supply device 25, which drives the mobile phase through a sample separation device 30 containing a stationary phase (e.g., a chromatographic column). The supply device 25 includes a first fluid component source for providing a first fluid or first solvent component A (e.g., water) and a second fluid component source for providing a second fluid or second solvent component B (e.g., an organic solvent). An optional degassing device 27 can degas the solvents provided by the first and second fluid component sources before supplying the solvents to the fluid driver 20.

[0077] The sampler (or injector) 40, also known as an injector, is located between the fluid driver 20 and the sample separation device 30 and is used to first draw a sample liquid or fluid sample from the sample container 180 into the sample holding volume in the injection path 195. Then, by switching the injection valve of the injector 40, the sample is introduced into the fluid separation path between the fluid driver 20 and the sample separation device 30 at the mixing point 45. The process of drawing the fluid sample from the sample container 180 can be performed specifically by extending and inserting the sample needle 150 into the sample container 180, drawing the fluid sample from the sample container 180 through the sample needle 150 into the sample holding volume 151 via a fluid transport device configured as a dispensing device, and then retracting the sample needle 150. The sample needle 150 is stationary during this process, and the extension and retraction are referred to as the ejection device (movable element).

[0078] The stationary phase of the sample separation device 30 is used to separate the components of the sample. A detector 50 (which may include a flow cell) detects the separated sample components. A fractionation device or fractionator 60 can be used to output the separated sample components into designated containers. No longer needed liquid can be output to a waste container or waste liquid pipeline.

[0079] The liquid path between the fluid driver 20 and the sample separation device 30 is usually in a high-pressure state, and the sample liquid is first input into the area separated from the liquid path of the sample injection unit or injector 40 at normal pressure, i.e., the sample loop or sample holding volume 151. Afterwards, the sample liquid is introduced into the separation path in a high-pressure state. The sample loop can be understood as a section of fluid conduit as a sample holding volume (also referred to as Sample Loop) for receiving or temporarily storing a certain amount of fluid sample. Preferably, before the sample liquid at normal pressure is switched from the sample holding volume 151 to the separation path in high pressure, the contents of the sample holding volume 151 are pressurized to the system pressure of the HPLC analysis device 10 by a dispensing device configured as a fluid conveying device. The control device 70 controls the various components 20, 25, 30, 40, 50, 60, 90, etc. of the analysis device 10.

[0080] The sample is injected into the needle seat 190, which is connected to the mixing position 45 via the sample injection path 195. Prior to injection, the sample is stored in the sample container 180. The sample processing device 100 is used to i) draw the sample from the sample container 180, ii) move the sample to the direction of the needle seat 190, and iii) inject the sample into the sample injection path 195.

[0081] The sample processing device 100 includes an object handling device 110, in this case a robotic arm, for handling / moving a fluid sample. To this end, a sample probe 150 (possibly further connected to a sample holding volume, such as a sample loop 151) is fixedly connected to the object handling device 110. The sample processing device 100 can be moved in all three spatial directions (x, y, z) within the sampler 40 via a drive device 140 (e.g., a motor).

[0082] In particular, the drive device 140 is configured to provide a driving force Z to the object processing device 110 to drive the object processing device 110 in the vertical direction (along the Z axis). In this way, the sample needle 150 can be moved (vertically) into and out of the sample container 180. In addition, the sample needle 150 can be moved (vertically) into and out of the needle seat 190.

[0083] To efficiently and reliably remove the sample needle 150 from the sample container 180, the sample processing device 100 includes a movable element 120 that is movably connected to the object processing device 110, such that the movable element 120 is at least partially movable relative to the fixedly connected needle 150. Illustratively, the movable element 120 includes a push-out device for pushing the sample container 180 away after a sample is removed from the sample container 180.

[0084] Figure 2A and 2B A sample processing device 100 according to an exemplary embodiment of the present invention is respectively shown.

[0085] Figure 2A A side view of a sample processing device 100 according to an embodiment is shown. In this side view, a fixing element 130 can be seen, which is located at the bottom of the object processing device 110 near the sample needle 150. In this example, the fixing element 130 serves as a fixing mechanism, holding the movable element 120 (here, the ejection device) in an initial position relative to the object processing device 110 by a holding force H. The fixing element 130 is configured to hold the movable element 120 in a bistable state (stable or metastable) by the holding force H.

[0086] When the object handling device 110 (via the drive device 140) is moved in the vertical direction to a surface (in particular the upper surface of the sample container 180) and pressed against this surface, the movable element 120 (here a passive device without its own drive device) is moved by pressure (in fact, a part of the movable element 120 (the lower area of ​​the guide structure 122) is pressed against the surface).

[0087] Furthermore, it can be seen in the side view that the movable element 120 essentially consists of three subelements: a guide structure 122, a spring element 125, and a lever element 126. The guide structure 122 is arranged partially around the fixed sample needle 150 (e.g., in the form of a plurality of rods). An end element is provided in the lower region of the guide structure 122, which has an opening 121. The tip of the sample needle 150 can be passed through this opening 121. This also serves to align the sample needle 150. The ejection device 120 can be moved relative to the (fixed) sample needle 150 so that the sample needle 150 can be extended and retracted through the opening 121. The guide structure 122 (in particular the end element) serves to actually remove the sample container 180 after sampling.

[0088] Furthermore, the movable element 120 includes a lever element 126 that movably connects the guide structure 122 to the object processing device 110. When the guide structure 122 is pressed against an object (e.g., a sample container 180) by the robot arm 110, the guide structure 122 (supported by the lever element 126) moves upward (deflects), thereby guiding the sample needle 150 through the opening 121 and exposing it.

[0089] Finally, the spring element 125 connects the lever element 126 to the object handling device 110, thereby providing a restoring force S. When the pressure of the drive device 140 is reduced, this restoring force S pulls the guide structure 122 and the lever element 126 back to their starting position. During this restoring process, the sample needle 150 (after sampling) is retracted through the opening 121 again. At this point, the movable element 120 (particularly the guide structure 122) acts as a peeling device for the sample container 180.

[0090] Figure 2B Another side view of a sample processing device 100 according to an embodiment is shown. Figure 2A , which shows the deflected state of the movable element 120. The guide structure 122 and the lever element 126 connected thereto are pushed upward, and the (fixed) sample needle 150 is pushed out through the opening 121, thereby being exposed for sampling. This shows that once the Z-direction pressure (applied by the drive device 140, which presses the robot arm 110 downward on the sample container 180) is no longer applied, the spring element 125 will pull the guide structure 122 and the lever element 126 back to the starting position through the reset force S.

[0091] Figure 2B The fixing mechanism 130 and Figure 2A The design is different. Figure 2B Two different fixing mechanisms 130 are schematically shown in FIG. Figure 2A The movable element 120 is thus fixed in the starting position. A first fixing mechanism 130 is designed as a fixing element, for example, a latch, for fixing the lever arm 126 in the deflected position (for example, by insertion). The second fixing mechanism 130 is designed as a fixing element 131 having multiple fixing positions. As shown schematically, this fixing element 131 is mounted next to the movable element 120 like a rod. Multiple fixing positions are provided along the rod (in the vertical direction), and the movable element 120 can be fixed at these positions.

[0092] In the example shown, the guide structure 122 is fixed in an uppermost fixed position, for example, by a magnet, a latch, etc. This allows for flexible locking in a desired position. As shown, it may be advantageous to fix the movable element 120 in a position where the sample needle 150 is exposed. For example, the sample needle 150 can be used to transport a sample container 180 in a special application.

[0093] Figures 3A to 3D The use of the sample processing device 100 according to an exemplary embodiment of the present invention is shown in detail.

[0094] Figure 3A The sample processing device 100 is shown, as described with respect to FIG. 2 , positioned above a sample container 180. Furthermore, it is shown that the lever element 126 of the movable element 120 is arranged (substantially) parallel to the robotic arm 110. Within the movable element 120, the lever element 126 is connected to a guide structure 122, which is responsible for the actual peeling of the sample container 180. As can be seen, the guide structure 122 can be pressed against the upper surface of the sample container 180 by the drive device 140 of the robotic arm 110, thereby causing the guide structure 122 and the lever element 126 to move upward (vertically). The lever element 126 is connected to the object processing device 110 via a spring element 125, so that once the pressure on the sample container 180 (applied by the drive device 140 of the robotic arm 110) decreases / stops, the movable element 120 returns to its original position due to the restoring force provided by the spring element 125.

[0095] exist Figure 3B In the embodiment of the present invention, the driving device 140 moves the object handling device or robot arm 110 downward in the direction of the sample container 180 by a driving force Z in the vertical direction z. In this example, the fixing mechanism is configured as a fixing element 130 (e.g., a magnet), which fixes the movable element 120 in its original position, i.e., the initial position. In this case, the holding force H is greater than the driving force Z. As a result, the movable element 120 does not move, and the pressure increases.

[0096] exist Figure 3C In the embodiment of FIG. 1 , the driving force Z increases, and as can be seen in the detailed diagram, the driving force Z overcomes the holding force H. The movable element 120 moves away from the fixed element 130, and the fixing mechanism is released. This separation may occur suddenly when a certain driving force is reached, and the precise separation point / area can be measured by applying a current to the driving device 140. For example, this precise separation point / area can be used for calibration.

[0097] exist Figure 3DIn the embodiment of the present invention, after the fixing mechanism 130 is released, the sample processing device 100 operates as described above, i.e. the sample needle 150 is guided through the opening 121 of the guide structure 122 in the movable element 120 (and aligned in the process) and finally inserted into the sample container 180 for sampling. The movable element 120 moves relative to the object processing device 110 and the sample needle 150, i.e. the guide structure 122 and the lever element 126 connected thereto are pushed upward. In the absence of the driving force Z (when the downward pressure is no longer applied), the restoring force S (triggered by the spring element 125) moves the movable element 120 back to its original position or initial position. The fixing mechanism 130 can act again and fix the movable element 120 in this initial position.

[0098] In other words, the magnet 130 (or other initial resistance) is used to create a hysteresis effect that locks / holds the movable element 120 / 126 until a defined force Z is reached in the z-direction. The current of the drive device 140 can be monitored to determine the time or current z-position when the movable element 120 is disengaged from the rigid arm portion 110.

[0099] Reference numerals

[0100] 10. Analytical equipment;

[0101] 20. Fluid drive;

[0102] 25. Feeding device;

[0103] 27. Degassing device;

[0104] 30. Sample separation device;

[0105] 40. Samplers, samplers, and injectors;

[0106] 50. Detector;

[0107] 60. Fractionator;

[0108] 70. Control device;

[0109] 100. Sample processing device;

[0110] 110. Object handling device, robotic arm;

[0111] 120. Movable element, ejection device;

[0112] 121. Channel opening;

[0113] 122. Guiding structure;

[0114] 125. Elastic element, spring element;

[0115] 126. Lever element;

[0116] 130. Fixing mechanism, fixing element;

[0117] 131. Fixed position;

[0118] 140. Driving device;

[0119] 150, sample needle;

[0120] 151. Sample holding volume;

[0121] 180. Sample container, sample bottle;

[0122] 190, needle holder;

[0123] 195. Injection path.

Claims

1. A device (100), in particular a sample processing device for an analytical device (10), comprising: an object handling device (110), in particular a robotic arm, the object handling device (110) being configured for handling an object, in particular for analyzing a sample; a needle (150), in particular a sample needle, the needle (150) being connected, in particular fixedly connected, to the object processing device (110); a movable element (120), in particular an ejection device, said movable element (120) being movably connected to said object handling device (110), wherein said movable element (120) is at least partially movable relative to said connected needle (150); and A fixing mechanism (130) is configured to fix the movable element (120) at at least one position, in particular at at least two positions.

2. The device (100) according to claim 1, wherein The movable element (120) is a passive element, in particular the movable element does not rely on a drive device (140), in particular a motor; and / or, The fixing mechanism (130) is a passive element, and in particular, the fixing mechanism (130) does not rely on a driving device (140).

3. The device (100) according to claim 1 or 2, wherein The at least one fixed position of the movable element (120) includes at least one of the following: a source position, an initial position, an end position, and a needle exposure position.

4. The device (100) according to any one of claims 1 to 3, wherein The fixing mechanism (130) is configured to fix the movable element (120) in two or more positions, The two or more positions are switched step by step or steplessly.

5. The device (100) according to any one of claims 1 to 4, wherein The fixing mechanism (130) includes at least one of the following means: snapping in, popping out, retracting, extending, pushing in, pushing out, inserting, pulling out, adhering, separating, clamping, releasing, deflecting, returning, a push-push mechanism, a lever mechanism, magnetic attraction, and electromagnetic attraction.

6. The device (100) according to any one of claims 1 to 5, wherein The fixing mechanism (130) includes a fixing element, and the fixing element includes at least one of the following: a magnet, an electromagnet, a spring, a snap, a suction cup, a hook and loop fastener, a reusable adhesive, a friction fit, a fixing pin, and a hook.

7. The device (100) according to any one of claims 1 to 6, further comprising: A positioning element, which predetermines one or more positions for fixing the movable element (120), in particular one or more positions in the vertical direction.

8. The device (100) according to any one of claims 1 to 7, wherein The fixing mechanism (130) can be triggered by at least one of the following methods: automatically, manually, artificially, through a control device, mechanically, electrically, pneumatically, or hydraulically.

9. The device (100) according to any one of claims 1 to 8, wherein The movable element (120) includes an ejection device, and the ejection device includes: a guide structure (122), the guide structure (122) being arranged at least partially around the needle (150), In particular, the ejection device comprises an end element having an opening (121), through which the needle (150) can be guided.

10. The device (100) according to any one of claims 1 to 9, wherein The needle (150) is at least partially exposed in at least one fixed position of the movable element (120).

11. The device (100) according to claim 10, wherein The device is configured so that the at least partially exposed needle (150) can be used to transport objects, in particular sample containers and / or filter elements.

12. The device (100) according to any one of claims 1 to 11, wherein The movable element (120) is movably connected to the object handling device via an elastic element (125), in particular via a spring, wherein, in particular, the connection comprises a lever element (126); and / or, The movable element (120) is configured to return to a source position after each movement; and / or, The elastic element (125) is configured to always move the movable element (120) back to the source position.

13. The device (100) according to any one of claims 1 to 12, wherein The object processing device (110) is configured to move the needle (150) to at least one of the following positions: a starting position, a sample container (180), a sampling position, a needle seat, a needle cleaning device, and a sample injection position.

14. The device (100) according to any one of claims 1 to 13, wherein The object processing device (110) is configured as a robotic arm, and in particular, a driving device (140) is provided at the end of the robotic arm.

15. The device (100) according to any one of claims 1 to 14, wherein The device (100) is configured as at least one of the following: a sample processing device, a dispensing device, a pipetting device, an injection device, a transport device, in particular for transporting sample containers.

16. A sampler (40) for an analytical device (10), wherein the sampler (40) comprises the apparatus (100) according to any one of claims 1 to 15.

17. An analytical device (10) for performing an analytical method, wherein The analysis device (10) include: The device (100) or the sampler (40) according to any one of claims 1 to 16.

18. The analytical device (10) according to claim 17, further comprising at least one of the following features: The analytical device (10) is configured as a sample separation device; The analytical device (10) includes a fluid driver (20) for driving a mobile phase and injecting a fluid sample into the mobile phase; The analytical device (10) comprises a sample separation device (30) for separating the fluid sample injected into the mobile phase; The analysis device (10) is configured to analyze at least one physical, chemical and / or biological parameter of the fluid sample; The analytical device (10) is configured as a sample separation device for separating the fluid sample; The analytical device (10) is a chromatograph, in particular a liquid chromatograph, a gas chromatograph, a supercritical fluid chromatograph (SFC) or a high performance liquid chromatograph (HPLC); The analytical device (10) is configured as a microfluidic device; The analytical device (10) is configured as a nanofluidic device; The sample separation device (30) is configured as a chromatographic separation device, in particular a chromatographic separation column; The fluid driver (20) is configured to drive the mobile phase and the fluid sample at high pressure; The fluid driver (20) is configured to drive the mobile phase and the fluid sample at a pressure of at least 500 Bar, in particular at least 1000 Bar, more in particular at least 1200 Bar; The analysis device (10) comprises a detector (50) for detecting a fluid sample to be analyzed (particularly separated); The analytical device (10) comprises a fractionator (60) for fractionating the separated components of the fluid sample.

19. A method comprising: movably connecting a movable element (120), in particular an ejection device, to an object handling device (110), said object handling device (110) being connected to a needle (150), such that said movable element (120) is at least partially movable relative to said connected needle (150); and, The movable element (120) is fixed in at least one position.

20. The method according to claim 19, wherein The movement of the movable element (120) is independent of the drive means; and / or, The fixing is performed independently of the drive device.

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