Antistatic medical gauze and preparation method thereof

Abstract

The invention discloses antistatic medical gauze and a preparation method thereof, and relates to the technical field of medical gauze. The antistatic medical gauze comprises the following raw materials in parts by mass: 60-80 parts of cotton fibers, 1-5 parts of an antistatic agent, 5-15 parts of a water-soluble polymer and 0.5-1 part of an antibacterial agent. Compared with the traditional technology that the antistatic effect is transient and is easily influenced by environmental factors, the invention realizes long-acting and stable charge neutralization capability by introducing a specific micromolecule antistatic agent (such as a compound shown in the formula 1) and combining a moisture absorption conductive mechanism, an ionization effect and surface energy regulation. The trend shows that the static dissipation is faster and the effect is lasting, the problems of potential safety hazards and dust adsorption caused by charge accumulation are effectively avoided, and the defect that the effect of an antistatic agent in the prior art is not lasting is overcome.

Description

Technical Field

[0001] This invention relates to the field of medical gauze technology, specifically to an antistatic medical gauze and its preparation method. Background Technology

[0002] In modern medical settings, medical gauze is a common medical supply widely used in wound care, surgical dressings, and various medical procedures. However, traditional medical gauze has a significant problem in practical applications—static electricity buildup. Static electricity not only causes the gauze to attract dust and microorganisms during use, reducing its cleaning effectiveness, but it can also cause discomfort to the human body and even pose safety hazards in certain situations.

[0003] This static electricity phenomenon is particularly severe in dry environments, especially in places with extremely high environmental requirements such as hospital operating rooms and intensive care units. Static electricity can interfere with the normal operation of medical equipment and, in extreme cases, even pose a potential threat to patients and medical staff. Furthermore, traditional medical gauze is insufficient in terms of antibacterial properties and comfort, failing to meet the urgent need for multifunctional materials in modern medicine.

[0004] Currently, common methods for solving static electricity problems include adding antistatic agents or using surface treatment techniques. However, these methods often have drawbacks such as short-lived effects, complex processing conditions, or high costs, making them difficult to widely apply in the field of medical gauze. Therefore, developing a new type of medical gauze that combines antistatic, antibacterial, and comfort properties is of great significance for improving medical quality and patient experience. Summary of the Invention

[0005] The present invention aims to provide a multifunctional medical gauze that combines antistatic, antibacterial and comfort properties. By introducing small molecule antistatic agents and highly efficient antibacterial agents, and optimizing the cotton fiber length and weaving process, the harm of static electricity is significantly reduced, the antibacterial performance is improved, and the user experience is enhanced.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is: a small molecule antistatic agent, wherein the antistatic agent is a compound represented by Formula 1:

[0007] Formula 1: ;

[0008] R1 in Formula 1 is selected from: cyano, alkyl with 1-5 carbon atoms;

[0009] Or R1 is selected from: alkyl groups with 1-5 carbon atoms substituted by cyano or hydroxyl groups.

[0010] Furthermore, the alkyl group having 1-5 carbon atoms is selected from: methyl, ethyl, propyl.

[0011] Furthermore, the antistatic agent is any one of the compounds shown in the following structures:

[0012] ;

[0013] .

[0014] An antistatic medical gauze, wherein the antistatic medical gauze includes an antistatic agent.

[0015] Furthermore, the antistatic medical gauze comprises the following raw materials in parts by weight: 60-80 parts cotton fiber, 1-5 parts antistatic agent, 5-15 parts water-soluble polymer, and 0.5-1 parts antibacterial agent;

[0016] The antistatic agent is the compound described in Formula 1.

[0017] Furthermore, the cotton fiber is combed cotton with a fiber length of 25-35mm.

[0018] Furthermore, the water-soluble polymer is selected from polyvinyl alcohol or sodium carboxymethyl cellulose.

[0019] Furthermore, the antibacterial agent is selected from hexadecyltrimethylammonium bromide or benzalkonium chloride.

[0020] A method for preparing antistatic medical gauze includes the following steps:

[0021] (1) The antistatic agent, water-soluble polymer and antibacterial agent are mixed in water to form solution A;

[0022] (2) Immerse the cotton fibers in the solution A to ensure full penetration, thereby obtaining soaked cotton fibers;

[0023] (3) The soaked cotton fibers are dried at 40-65℃ to obtain modified cotton fibers;

[0024] (4) The modified cotton fibers are woven to make medical gauze.

[0025] Furthermore, the weaving in step (4) is performed using a circular knitting machine or a flat knitting machine to weave medical gauze into a plain weave structure or a mesh structure, wherein the mesh density is 10-20 meshes / square centimeter.

[0026] The antistatic mechanism of the antistatic agent described in this invention mainly includes: hygroscopic conductivity, ionization, and surface energy regulation. The triazine group in the molecular structure serves as the molecular core, forming an electron-rich heterocyclic structure with strong polarity and hydrogen bond formation ability. It can effectively adsorb moisture from the environment, forming a thin water film. This water film acts as a conductor, rapidly dissipating static charge (the main cause of static accumulation is charge retention due to material insulation). Simultaneously, the triazine group's cyclic structure provides stability, ensuring a long-lasting antistatic effect and overcoming the short-lived effect of traditional antistatic agents. The hydroxyl (-OH) and carboxylic acid (-COOH) groups are strongly hydrophilic groups that can ionize in aqueous solutions. The hydroxyl group enhances moisture adsorption through hydrogen bonding, while the carboxylic acid group ionizes to generate carboxylate ions and protons, forming ion channels. These ions migrate on or within the material surface, significantly improving conductivity (reducing resistance), thereby neutralizing static charge. The alkane chain in the structure imparts a certain degree of hydrophobicity to the antistatic agent, allowing it to be uniformly dispersed on the surface of cotton fibers. Meanwhile, the alkane chains are compatible with the natural hydrophobic regions of cotton fibers, reducing interfacial energy and promoting the uniform coating of antistatic agents on the fibers. This coating film forms a "conductive mesh structure," which not only neutralizes static electricity but also enhances the mechanical strength and abrasion resistance of the gauze.

[0027] Small-molecule antistatic agents serve as the core component, directly addressing the issue of static electricity accumulation. Their structure (as shown in Formula 1) neutralizes static charge effectively through hygroscopic conductivity, ionization, and surface energy regulation, preventing charge retention. Cotton fibers, as the main body of the gauze, provide the foundation for comfort and breathability. The moderate length of combed cotton fibers (25-35mm) ensures the gauze is soft and breathable, reducing patient discomfort. During preparation, cotton fibers are impregnated in an antistatic agent solution. The natural hydrophobic regions on the fiber surface are compatible with the alkane chains of the antistatic agent, promoting uniform coating. This enhances the formation of a conductive network structure without compromising the fiber's natural comfort. The physical structure of cotton fibers (such as fiber length) provides a stable carrier for the antistatic and antibacterial agents, ensuring synergistic effects. Water-soluble polymers primarily act as carriers and binders. The water-soluble polymers, mixed with the antistatic and antibacterial agents in water, form solution A. Their water solubility helps the antistatic and antibacterial agents disperse evenly, preventing agglomeration and ensuring uniform penetration of each component onto the fiber surface. During the drying process, the polymer forms a thin film that firmly adheres the antistatic and antibacterial agents to the cotton fibers, preventing component detachment. This not only stabilizes the antistatic effect but also indirectly supports the continuous release of the antibacterial agent. By optimizing the solution viscosity, the water-soluble polymer ensures thorough penetration during impregnation, maximizing the contact area between components and improving overall performance. The antibacterial agent effectively kills or inhibits microorganisms, preventing wound infection. The antistatic agent reduces the electrostatic adsorption of dust and microorganisms, indirectly reducing the risk of contamination; simultaneously, the antibacterial agent releases active ions more readily in an ionized environment, enhancing antibacterial efficiency.

[0028] Compared with the prior art, the beneficial effects of the present invention are:

[0029] 1. Significantly Improved Long-Lasting Antistatic Performance: Compared to traditional technologies where the antistatic effect is short-lived and easily affected by environmental factors, this invention, by introducing specific small-molecule antistatic agents (such as the compound shown in Formula 1), combined with hygroscopic conductivity, ionization, and surface energy modulation, achieves long-lasting and stable charge neutralization capabilities. This trend manifests as faster and more durable static electricity dissipation, effectively avoiding safety hazards and dust adsorption problems caused by charge accumulation, and overcoming the shortcomings of existing antistatic agents that have short-lasting effects.

[0030] 2. Significantly Enhanced Antibacterial Stability: Existing medical gauze often faces the problem of antibacterial properties decaying over time. This invention integrates antistatic agents and highly effective antibacterial agents (such as hexadecyltrimethylammonium bromide) into the gauze, forming a synergistic mechanism to ensure long-term stability of the antibacterial effect. The trend shows that the antibacterial rate only decreases slightly over time, maintaining a high level of antibacterial activity, significantly reducing bacterial growth and the risk of infection, and improving hygiene and safety in medical environments.

[0031] 3. Overall Optimization of Performance and Comfort: Compared to the shortcomings of existing gauze technologies, such as poor comfort and complex processing, this invention achieves a synergistic improvement in the mechanical strength, abrasion resistance, and breathability of the gauze by optimizing cotton fiber length, adding water-soluble polymers, and modifying weaving processes (e.g., controlling mesh density using a circular knitting machine). This trend is reflected in the improved overall user experience of the gauze, including reduced patient discomfort, enhanced durability, and simplified manufacturing processes, thereby meeting the higher demands of modern medicine for multifunctional materials. Attached Figure Description

[0032] Figure 1 This is the NMR spectrum of the antistatic agent 1 described in this invention. Detailed Implementation

[0033] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] Preparation Example 1

[0035] Preparation of antistatic agent 1:

[0036] ;

[0037] Step 1: Under nitrogen protection, 20g of raw material 1 and 20.11g of raw material 2 were dissolved in 250ml of toluene solution. 20.31g of sodium tert-butoxide, 2.90g of tris(dibenzylacetone)palladium, and 1.07g of tri-tert-butylphosphine were added. The mixture was stirred until homogeneous, heated to 120℃, and refluxed for 12h. After the reaction was completed, the temperature was slightly lowered, and the mixture was filtered with diatomaceous earth to remove salts and catalysts. After the filtrate was cooled to room temperature, it was washed three times with water, retaining the organic phase. The aqueous phase was then extracted with ethyl acetate. The organic phases were combined, evaporated to dryness, and subjected to column chromatography (silica gel column chromatography, using a mixed solution of petroleum ether and ethyl acetate as the eluent). After evaporation to dryness, 14.70g of intermediate 1 was obtained.

[0038] ;

[0039] Step 2: Under nitrogen protection, 14.70 g of intermediate 1 and 15.24 g of raw material 3 were dissolved in 200 ml of toluene solution. 9.07 g of sodium tert-butoxide, 1.30 g of tris(dibenzylacetone)palladium, and 0.5 g of tri-tert-butylphosphine were added. The mixture was stirred until homogeneous, heated to 120 °C, and refluxed for 12 h. After the reaction was completed, the temperature was slightly lowered, and the mixture was filtered using diatomaceous earth to remove salts and catalysts. The filtrate was cooled to room temperature and washed three times with water, retaining the organic phase. The aqueous phase was then extracted with ethyl acetate. The organic phases were combined, evaporated to dryness, and subjected to column chromatography (silica gel column chromatography, using a mixed solution of petroleum ether and ethyl acetate as the eluent). After evaporation to dryness, 18.67 g of antistatic agent 1 was obtained.

[0040] Product structure identification:

[0041] Mass spectrometry of intermediate 1 (M / Z MS+1): 312;

[0042] Mass spectrometry of antistatic agent 1 (M / Z MS+1:500);

[0043] Antistatic agent 1 1 H NMR (Chloroform-d), Figure 1 : δ 5.04 (s, 1H), 4.16-3.97 (m, 3H), 3.91-3.75 (m, 3H), 3.61-3.51 (m, 4H), 3.38 (s, 3H), 3.12 (d, 2H), 2.71(t, 2H), 2.34 (s, 3H), 2.07-1.94 (m, 1H), 1.87-1.73 (m, 1H), 1.71-1.51 (m,5H), 1.49-1.37 (m, 5H), 1.37-1.25 (m, 6H), 0.96-0.87 (m, 6H).

[0044] Preparation Examples 2-6

[0045] In Preparation Examples 2-6, antistatic agent 2-antistatic agent 5 were synthesized sequentially, following the preparation method of Preparation Example 1, except that raw material 2 was replaced, and the rest remained the same as in Preparation Example 1. See Table 1 for details.

[0046] Table 1.

[0047] Raw material 2 structure Structure of antistatic agent 2-antistatic agent 5 Product structure identification mass spectrometry M / Z MS+1 Preparation Example 2 514 Preparation Example 3 528 Preparation Example 4 511 Preparation Example 5 525 Preparation Example 6 530

[0048] Example 1

[0049] Preparation of an antistatic medical gauze:

[0050] 1. Raw material composition:

[0051] Cotton fiber: 70 parts (combed cotton, fiber length 30 mm, purchased from Zhejiang Xinmian Textile Co., Ltd.); Antistatic agent: 3 parts (using antistatic agent 1 obtained in Preparation Example 1);

[0052] Soluble polymer: 10 parts (polyvinyl alcohol, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.);

[0053] Antibacterial agent: 0.8 parts (chosen cetyltrimethylammonium bromide, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.);

[0054] Water: Used as a solvent, in an amount of 200 parts (deionized water).

[0055] 2. Preparation method:

[0056] (1) Mix 3 parts of antistatic agent, 10 parts of polyvinyl alcohol, and 0.8 parts of hexadecyltrimethylammonium bromide in 200 parts of water. Stir at 200 rpm for 30 minutes at room temperature (25°C) until a homogeneous and transparent solution A is formed;

[0057] (2) 70 parts of combed cotton fiber were immersed in solution A. The immersion process was carried out at 40°C for 60 minutes, with intermittent stirring during the process (stirring once every 10 minutes for 5 minutes each time). After completion, the immersed cotton fiber was removed and excess solution was drained to obtain uniformly modified immersed cotton fiber.

[0058] (3) Place the soaked cotton fibers in a drying oven and dry them at 50°C for 120 minutes. After drying, the fiber moisture content is less than 5%, resulting in dried modified cotton fibers;

[0059] (4) Modified cotton fibers are woven into plain weave medical gauze using a circular knitting machine. The weaving parameters are set as follows: mesh density 15 mesh / cm². After weaving, the gauze is cut and edge-treated to obtain the finished antistatic medical gauze.

[0060] Examples 2-6

[0061] The preparation of an antistatic medical gauze is carried out by referring to the preparation method of Example 1, except that the antistatic agent is replaced sequentially with antistatic agent 2-antistatic agent 6, and the rest is the same as in Example 1.

[0062] Comparative Example 1

[0063] The preparation of an antistatic medical gauze follows the method described in Example 1, except that the antistatic agent is replaced with antistatic agent SN (CAS: 86443-82-5). The rest remains the same as in Example 1.

[0064] Comparative Example 2

[0065] The preparation of an antistatic medical gauze is carried out according to the preparation method of Example 1, except that the antistatic agent is replaced with antistatic agent TM (purchased from Changzhou Deenyuan New Material Technology Co., Ltd.), and the rest is the same as in Example 1.

[0066] Comparative Example 3

[0067] The preparation of an antistatic medical gauze follows the same method as in Example 1, except that no antistatic agent is added, and the rest remains the same as in Example 1.

[0068] Comparative Example 4

[0069] The preparation of an antistatic medical gauze follows the same method as in Example 1, except that no antibacterial agent is added, and the rest remains the same as in Example 1.

[0070] Performance testing:

[0071] (1) Antibacterial properties and antibacterial stability: The test was conducted according to GB / T 20944.3-2008 Evaluation of antibacterial properties of textiles - Part 3: Shaking bottle method. The antibacterial properties were tested again after 28 days and 56 days using the same method. The test strain was Staphylococcus aureus. The data are shown in Table 2.

[0072] Antistatic performance evaluation: The antistatic medical gauze prepared in the example was tested according to the national standard GB / T 12703.1-2008 "Evaluation of electrostatic properties of textiles - Part 1: Static voltage and half-life". The test conditions were 20℃ and 35% relative humidity. After the gauze was left to stand for 56 days, the measurement was taken again, and the half-life (s) of the electrostatic voltage was used for evaluation. A shorter half-life indicates better antistatic performance (because the static charge dissipates quickly). The data are shown in Table 2.

[0073] Table 2.

[0074] 0-day antibacterial rate (%) 28-day antibacterial rate (%) 56-day antibacterial rate (%) Half-life (s) Half-life (s) after 56 days Example 1 99.9 99.8 99.6 0.3 0.3 Example 2 99.9 99.9 99.7 0.2 0.2 Example 3 99.9 99.9 99.7 0.2 0.3 Example 4 99.9 99.9 99.6 0.4 0.4 Example 5 99.9 99.7 99.4 0.3 0.4 Example 6 99.9 99.9 99.7 0.1 0.2 Comparative Example 1 93.6 93.0 92.6 1.1 1.4 Comparative Example 2 94.1 93.8 93.0 1.5 2.2 Comparative Example 3 90.8 90.0 89.2 4.6 5.9 Comparative Example 4 50.3 45.6 41.8 1.5 1.6

[0075] All example groups (using the antistatic agent of the present invention) exhibited highly stable antibacterial effects, with the antibacterial rate decreasing only slightly over time, maintaining a near-perfect level. In contrast, the control group showed a lower initial antibacterial rate, which continued to decline over time, indicating significant performance degradation. Regarding antistatic performance, half-life is a key indicator (a short half-life indicates rapid dissipation of static charge and strong antistatic properties). The example groups generally had very short half-lives, demonstrating excellent antistatic properties. In contrast, the control group had a significantly longer half-life, indicating poorer antistatic effects. This is directly related to the effectiveness of the antistatic agent: the antistatic agent in the example groups effectively neutralizes charge through hygroscopic conductivity and ionization, thereby shortening the half-life; while the control group, due to improper selection or absence of antistatic agent, experienced increased charge accumulation, leading to a prolonged half-life, further affecting the overall safety and practicality of the gauze. Overall, the antistatic agent design of the present invention significantly improves the stability of antistatic performance while maintaining long-lasting antibacterial effects.

[0076] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A small molecule antistatic agent, characterized in that, The antistatic agent is a compound represented by Formula 1: Formula 1: ; R1 in Formula 1 is selected from: cyano, alkyl with 1-5 carbon atoms; Or R1 is selected from: alkyl groups with 1-5 carbon atoms substituted by cyano or hydroxyl groups.

2. The small molecule antistatic agent according to claim 1, characterized in that, The alkyl group having 1-5 carbon atoms is selected from: methyl, ethyl, propyl.

3. The small molecule antistatic agent according to claim 1, characterized in that, The antistatic agent is any one of the compounds shown in the following structures: ； 。 4. An antistatic medical gauze, characterized in that, The antistatic medical gauze includes the antistatic agent as described in any one of claims 1-3.

5. The antistatic medical gauze according to claim 4, characterized in that, The antistatic medical gauze comprises the following raw materials in parts by weight: 60-80 parts cotton fiber, 1-5 parts antistatic agent, 5-15 parts water-soluble polymer, and 0.5-1 part antibacterial agent; The antistatic agent is the compound described in Formula 1.

6. The antistatic medical gauze according to claim 5, characterized in that, The cotton fiber is combed cotton with a fiber length of 25-35mm.

7. The antistatic medical gauze according to claim 5, characterized in that, The water-soluble polymer is selected from polyvinyl alcohol or sodium carboxymethyl cellulose.

8. The antistatic medical gauze according to claim 5, characterized in that, The antibacterial agent is selected from hexadecyltrimethylammonium bromide or benzalkonium chloride.

9. A method for preparing an antistatic medical gauze according to any one of claims 4-8, characterized in that, Includes the following steps: (1) The antistatic agent, water-soluble polymer and antibacterial agent are mixed in water to form solution A; (2) Immerse the cotton fibers in the solution A to ensure full penetration, thereby obtaining soaked cotton fibers; (3) The soaked cotton fibers are dried at 40-65℃ to obtain modified cotton fibers; (4) The modified cotton fibers are woven to make medical gauze.

10. The method for preparing an antistatic medical gauze according to claim 9, characterized in that, The weaving in step (4) is done using a circular knitting machine or a flat knitting machine to weave medical gauze into a plain weave or mesh structure, wherein the mesh density is 10-20 meshes / square centimeter.

Images