Multi-effect traditional Chinese medicine formula capable of smoothly breathing and nano sustained-release preparation method

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a multi-effect traditional Chinese medicine formula capable of smoothly breathing and a nano sustained-release preparation method. Aiming at the problem of poor treatment effect of similar products in the prior art, the invention provides a multi-effect traditional Chinese medicine formula capable of smoothly breathing and a nano sustained-release preparation method, the multi-effect traditional Chinese medicine formula capable of smoothly breathing comprises a monarch drug, a ministerial drug, an adjuvant drug and a conductant drug, the monarch drug comprises platycodon grandiflorum and scutellaria baicalensis, the ministerial drug comprises mint and radix bupleuri, the adjuvant drug comprises radix stemonae, radix angelicae, fennel and sandalwood, and the conductant drug comprises radix angelicae, radix angelicae, fructus foeniculi and lignum santali albi. The conductant drug comprises liquorice and michelia alba. The invention provides a traditional Chinese medicine formula taking platycodon grandiflorum, scutellaria baicalensis, mint, radix bupleuri, radix stemonae, radix angelicae, fennel, sandalwood, liquorice and michelia alba as main components, effective components are extracted and prepared through a unique nano slow-release preparation process, and the obtained traditional Chinese medicine finished product has a remarkable treatment effect on unsmooth breath.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a multi-effect traditional Chinese medicine formula for smooth breathing and a nano-sustained release preparation method. BACKGROUND

[0002] The respiratory system contacts the external environment most frequently among various systems of the human body, and has a large contact area. In a resting state, 12000L of gas enters and exits the respiratory tract of an adult per day. In the respiratory process, organic or inorganic dust in the external environment, including various microorganisms, foreign protein allergens, dust particles and harmful gases, etc. can be inhaled into the respiratory tract and lungs to cause various diseases. Respiratory diseases are common and frequently-occurring diseases, such as cold, cough, pharyngitis, rhinitis, tracheitis, emphysema, pulmonary heart disease, asthma and headache, sore throat and pain caused by haze, etc. These respiratory diseases are basically treated by oral administration of drugs and intramuscular injection and intravenous injection, which has the disadvantages of low drug conversion rate, slow effect, inconvenience of use and long cure time.

[0003] In view of the problem, people have also made exploratory research in long-term production and life practice. For example, a Chinese invention patent application discloses a composition for treating respiratory diseases, an inhaled traditional Chinese medicine preparation and a preparation method [application number: 201810125596.6]. The required raw materials include 3-8 parts of Daphne, dried tangerine or orange peel, Platycodon root, Ophiopogon japonicus, Coltsfoot flower, Radix Isatidis, Polygala, and 7-10 parts of red vitriol and Herba Hedyotis diffusae.

[0004] The invention patent application has the advantage of not needing intravenous injection, but the treatment effect of the raw material formula composition on the symptom of difficult breathing is still very limited. SUMMARY

[0005] The purpose of the present application is to provide a multi-effect traditional Chinese medicine formula for smooth breathing.

[0006] Another purpose of the present application is to provide a nano-sustained release preparation method of the multi-effect traditional Chinese medicine formula for smooth breathing.

[0007] To achieve the above purpose, the present application adopts the following technical scheme:

[0008] A multi-effect traditional Chinese medicine formula for smooth breathing comprises monarch drugs, minister drugs, auxiliary drugs and ministerial drugs. The monarch drugs comprise Platycodon and Scutellaria; the minister drugs comprise Mentha and Bupleurum; the auxiliary drugs comprise Farfarae, Angelica dahurica, Cuminum and Santalum album; and the ministerial drugs comprise Glycyrrhiza and Magnolia.

[0009] Platycodon: The largest dosage in this formula, platycodon can directly relieve the symptoms of chest tightness, cough and phlegm caused by asthma, and its volatile oil components (such as platycodon saponin) can promote the discharge of respiratory secretions and reduce airway obstruction.

[0010] Scutellaria: Clearing heat and dampness, purging fire and detoxifying, it is aimed at the heat asthma syndrome (thick and yellow phlegm, fever) in asthma, and its terpenoids have high fat solubility, can quickly pass through the respiratory mucosa, and have antibacterial and anti-inflammatory effects.

[0011] Mint: Dispelling wind and heat, promoting rash and relieving throat, its volatile oil contains menthol (more than 80%), which can relax bronchial smooth muscle, relieve asthma and laryngeal spasm, and has anti-inflammatory and analgesic effects, which can assist the monarch drug in clearing heat and relieving asthma.

[0012] Bupleurum: Resolving heat and relieving depression, its volatile oil components (such as saikosaponin) can regulate immunity, relieve the chest distention and low fever associated with asthma, and enhance the anti-inflammatory effect of scutellaria.

[0013] Stemona: Moistening the lungs and relieving cough, it can relieve the stubborn cough and excessive phlegm in asthma, and its volatile oil can promote the secretion of serous glands and reduce the viscosity of phlegm, thereby relieving the symptoms of excessive and thick phlegm. However, due to the strong irritability of its volatile oil, special treatment is required to retain its effect while reducing its irritability.

[0014] Angelica: Dispelling wind and cold, dredging the orifices and relieving pain, its volatile oil (such as angelica sinensis) has anti-allergic and bronchodilatory effects, and can balance cold and heat for the symptoms of nasal congestion, runny nose and other allergic symptoms in asthma.

[0015] Fennel: Regulating qi and stomach, warming the middle and dispelling cold, its volatile oil (such as fenchyl valerate) can relieve the vomiting caused by the irritation of volatile oil or sensitivity to fragrance, and reduce the digestive discomfort (such as belching and abdominal distension) of asthma patients.

[0016] Sandalwood: Qi-regulating and pain-relieving, antibacterial and anti-inflammatory, low-dose volatile oil can have a calming effect, improve anxiety and chest pain caused by asthma, and inhibit respiratory bacteria.

[0017] Glycyrrhiza: Tonifying the spleen and qi, clearing heat and detoxifying, it can balance the properties of other drugs and reduce their irritability. The ester components obtained from glycyrrhiza through supercritical carbon dioxide extraction can balance the volatile oils in the formula.

[0018] Magnolia: Aromatic and dampness-removing, regulating qi and relieving chest, its fragrance is high and refreshing, and as a leading drug, it guides the volatile oil components to act on the upper jiao (lungs), and its sesquiterpene volatile oil can improve chest tightness and hypoxia, and assist licorice in balancing.

[0019] In the above-mentioned multi-effect traditional Chinese medicine formula for smooth breathing, the traditional Chinese medicine formula comprises the following components in the following weight proportions:

[0020] Platycodon 8-16 parts;

[0021] Scutellaria 2-4 parts;

[0022] Mentha 2-10 parts;

[0023] Bupleurum 2-10 parts;

[0024] Stachys 4-8 parts;

[0025] Angelica 0.5-2 parts;

[0026] Fennel 0.1-1 part;

[0027] Sandalwood 0.05-0.2 parts;

[0028] Glycyrrhiza 1-5 parts;

[0029] Magnolia 2-10 parts.

[0030] In the above-mentioned multi-effect traditional Chinese medicine formula for smooth breathing, the traditional Chinese medicine formula comprises the following components in parts by weight:

[0031] Platycodon 12 parts;

[0032] Scutellaria 3 parts;

[0033] Mentha 6 parts;

[0034] Bupleurum 6 parts;

[0035] Stachys 6 parts;

[0036] Angelica 1 part;

[0037] Fennel 0.5 part;

[0038] Sandalwood 0.1 part;

[0039] Glycyrrhiza 3 parts;

[0040] Magnolia 6 parts.

[0041] A method for preparing the above-mentioned multi-effect traditional Chinese medicine formula for smooth breathing, comprising the following steps:

[0042] Step one: adding Platycodon, Scutellaria, Mentha, Bupleurum, Stachys, Angelica, Fennel, Sandalwood, Glycyrrhiza and Magnolia into a super micro grinder for grinding to obtain a traditional Chinese medicine powder with a particle size of 1000-2000 nm;

[0043] Step two: the Chinese medicine powder prepared in step one and PEG200 are mixed by a blender for 70-90 minutes to form a liquid-phase Chinese medicine mixture, which is then put into a heatable container and heated to 70-80℃, and then sheared by a high-speed shearing machine at a speed of 3000-5000r / min for 60-1200 minutes to break the cell walls of the Chinese medicine and dissolve the plant oil components in the Chinese medicine and PEG200, so as to obtain a liquid-phase mixture, wherein the particle size of the Chinese medicine particles in the liquid-phase mixture is 200-800nm, and the high-speed shearing machine can be a high-speed shearing machine produced by Zhejiang Ketun Machinery Co., Ltd.

[0044] Step three: the liquid-phase mixture prepared in step two, water and ethanol are mixed and dissolved, and then extracted by a supercritical carbon dioxide extraction device at 40-50℃ and 6-7MPa, and then the extract is extracted by water steam distillation at 100-150℃ to obtain a Chinese medicine extract;

[0045] Step four: the Chinese medicine extract prepared in step three, polyethylene glycol, chitosan and nanosilica are uniformly mixed and heated to 90℃, and stirred for 30 minutes to obtain a Chinese medicine extract nanoscale slow-release mixture;

[0046] Step five: nitrogen ketone is added to the Chinese medicine extract nanoscale slow-release mixture prepared in step four, and after sterile treatment, a wet wipe, spray, gel or ointment type external use Chinese medicine is prepared.

[0047] In the above preparation method, the mass ratio of PEG200 to Chinese medicine powder in step two is 7:3, and the stirring speed of the blender is 100r / min.

[0048] In the above preparation method, the mass ratio of the liquid-phase mixture, water and ethanol in step three is 1:2:2.

[0049] In the above preparation method, the Chinese medicine powder in step two is further mixed with vitamin E and cyclodextrin before being mixed with PEG200; the amount of vitamin E is 1-1.2% of the total mass of the Chinese medicine powder, and the amount of cyclodextrin is 0.2-2.5% of the total mass of the Chinese medicine powder.

[0050] In the above preparation method, lecithin is further added to the Chinese medicine extract in step four, and the mass of lecithin is 5-6% of the total mass of the Chinese medicine extract and polyethylene glycol.

[0051] In the above preparation method, the components in step four are mixed according to the following mass fractions: Chinese medicine extract 30 parts, polyethylene glycol 68 parts, chitosan 1.5 parts and nanosilica 0.5 parts.

[0052] In the preparation method, the mass of the nitroketone in step five is 1-3% of the mass of the traditional Chinese medicine extract nano-sustained release mixture.

[0053] Compared with the prior art, the present application has the advantages of:

[0054] The present application provides a traditional Chinese medicine formula with jiegeng, huangqi, bohe, chaihu, baibu, baizhi, xiaohuixiang, tantan, gancao and bai lanhua as main components, and the effective components are extracted and prepared by a unique nano-sustained release preparation process, and the prepared traditional Chinese medicine product has a significant therapeutic effect on breathlessness. DETAILED DESCRIPTION

[0055] The present application will be further described in detail in combination with specific embodiments.

[0056] Embodiment 1

[0057] The present embodiment provides a multi-effect traditional Chinese medicine formula for smooth breathing and a nano-sustained release preparation method, which comprises the following components by weight:

[0058] Jiegeng 16 parts;

[0059] Huangqi 2 parts;

[0060] Bohe 2 parts;

[0061] Chaihu 2 parts;

[0062] Baibu 4 parts;

[0063] Baizhi 0.5 parts;

[0064] Xiaohuixiang 0.1 parts;

[0065] Tantan 0.05 parts;

[0066] Gancao 1 part;

[0067] Bailanhua 2 parts.

[0068] And the following method is used for preparation:

[0069] Step one: jiegeng, huangqi, bohe, chaihu, baibu, baizhi, xiaohuixiang, tantan, gancao and bailanhua are added to a super micro grinder for grinding to obtain a traditional Chinese medicine powder with a particle size of 1000-2000 nm;

[0070] Step two: the Chinese medicine powder prepared in step one and PEG200 are mixed by a blender at a stirring speed of 100 r / min for 90 min, the mass ratio of PEG200 to Chinese medicine powder is 7:3, to form a liquid-phase Chinese medicine mixture, which is heated to 80℃ in a heatable container, and then sheared by a high-speed shearing machine at a speed of 5000 r / min for 1200 min to obtain a liquid-phase mixture, the particle size of the Chinese medicine particles in the liquid-phase mixture is 200-800 nm;

[0071] Step three: the liquid-phase mixture prepared in step two, water and ethanol are mixed and dissolved, the mass ratio of the liquid-phase mixture, water and ethanol is 1:2:2, extraction is carried out by a supercritical carbon dioxide extraction equipment at 50℃ and 7 MPa, and the extract is extracted by water distillation at 150℃ to obtain a Chinese medicine extract;

[0072] Step four: lecithin is added to 30 parts of the Chinese medicine extract prepared in step three, which is then mixed uniformly with 68 parts of polyethylene glycol, 1.5 parts of chitosan and 0.5 parts of nano-silicon dioxide, and heated to 90℃, stirred for 30 min to obtain a Chinese medicine extract nano-sustained-release mixture, the mass of lecithin is 6% of the total mass of the Chinese medicine extract and polyethylene glycol;

[0073] Step five: nitrogen ketone is added to the Chinese medicine extract nano-sustained-release mixture prepared in step four, the mass of nitrogen ketone is 3% of the mass of the Chinese medicine extract nano-sustained-release mixture, and after sterile treatment, a wet wipe, a spray, a gel or a paste type external use Chinese medicine is prepared.

[0074] Example 2

[0075] The present embodiment provides a multi-effect Chinese medicine formula that can be smoothly breathed and a nano-sustained-release preparation method, which comprises the following components by weight:

[0076] Platycodon 8 parts;

[0077] Scutellaria 4 parts;

[0078] Mint 8 parts;

[0079] Bupleurum 8 parts;

[0080] Stachys 8 parts;

[0081] Angelica 2 parts;

[0082] Fennel 1 part;

[0083] Sandalwood 0.2 parts;

[0084] Liquorice 5 parts;

[0085] Magnolia 8 parts.

[0086] And the following method is used for preparation:

[0087] Step one: add Platycodon, Scutellaria, Mentha, Bupleurum, Stachys, Angelica, Dalbergia, Glycyrrhiza and Magnolia to the ultrafine grinder for grinding, to obtain a traditional Chinese medicine powder with a particle size of 1000-2000 nm;

[0088] Step two: mix the traditional Chinese medicine powder prepared in step one with PEG200 by stirring at a stirring speed of 100 r / min for 70 min, the mass ratio of PEG200 to traditional Chinese medicine powder being 7:3, to form a liquid-phase traditional Chinese medicine mixture, and then put the mixture into a heatable container and heat it to 70℃, and then use a high-speed shearing machine to shear at a speed of 3000 r / min for 60 min, to obtain a liquid-phase mixture, the particle size of the traditional Chinese medicine particles in the liquid-phase mixture being 200-800 nm;

[0089] Step three: mix and dissolve the liquid-phase mixture prepared in step two, water and ethanol, the mass ratio of the liquid-phase mixture, water and ethanol being 1:2:2, and then perform extraction by a supercritical carbon dioxide extraction device under the conditions of 40℃ and 6 MPa, and then perform distillation extraction of the extract by using water at 100℃, to obtain a traditional Chinese medicine extract;

[0090] Step four: add lecithin to 30 parts of the traditional Chinese medicine extract prepared in step three, and then mix it uniformly with 68 parts of polyethylene glycol, 1.5 parts of chitosan and 0.5 parts of nano silicon dioxide, and heat to 90℃, and stir for 30 min, to obtain a traditional Chinese medicine extract nano slow-release mixture, the mass of lecithin being 5% of the total mass of the traditional Chinese medicine extract and polyethylene glycol;

[0091] Step five: add azone to the traditional Chinese medicine extract nano slow-release mixture prepared in step four, the mass of azone being 1% of the mass of the traditional Chinese medicine extract nano slow-release mixture, and then perform sterile treatment to prepare a wet wipe, spray, gel or ointment type external use traditional Chinese medicine.

[0092] Example 3

[0093] The present embodiment provides a multi-effect traditional Chinese medicine formula that can be smoothly breathed and a nano slow-release preparation method, which comprises the following components by weight:

[0094] Platycodon 12 parts;

[0095] Scutellaria 3 parts;

[0096] Mentha 6 parts;

[0097] Bupleurum 6 parts;

[0098] Stachys 6 parts;

[0099] Angelica 1 part;

[0100] Dalbergia 0.5 part;

[0101] Sandalwood 0.1 parts;

[0102] Glycyrrhiza 3 parts;

[0103] Magnolia 6 parts.

[0104] And the following method is prepared:

[0105] Step one: add Platycodon, Scutellaria, Mentha, Bupleurum, Stachys, Angelica, Fennel, Sandalwood, Glycyrrhiza and Magnolia into the ultrafine grinder to be ground, to obtain the traditional Chinese medicine powder with a particle size of 1000-2000nm;

[0106] Step two: mix the traditional Chinese medicine powder prepared in step one with PEG200 by a blender at a stirring speed of 100r / min for 80min, the mass ratio of PEG200 to traditional Chinese medicine powder is 7:3, to form a liquid-phase traditional Chinese medicine mixture, put the mixture into a heatable container and heat the mixture to 75℃, then use a high-speed shearing machine to shear at a speed of 4000r / min for 500min, to obtain a liquid-phase mixture, the particle size of the traditional Chinese medicine particles in the liquid-phase mixture is 200-800nm;

[0107] Step three: mix and dissolve the liquid-phase mixture prepared in step two, water and ethanol, the mass ratio of the liquid-phase mixture, water and ethanol is 1:2:2, extract by a supercritical carbon dioxide extraction equipment under the conditions of 45℃ and 6.5MPa, and then use 120℃ water distillation extraction, to obtain a traditional Chinese medicine extract;

[0108] Step four: add lecithin to 30 parts of the traditional Chinese medicine extract prepared in step three, then mix evenly with 68 parts of polyethylene glycol, 1.5 parts of chitosan and 0.5 parts of nano silicon dioxide, and heat to 90℃, stir for 30min, to obtain a traditional Chinese medicine extract nano slow-release mixture, the mass of lecithin is 5.5% of the total mass of the traditional Chinese medicine extract and polyethylene glycol;

[0109] Step five: add azone to the traditional Chinese medicine extract nano slow-release mixture prepared in step four, the mass of azone is 2% of the mass of the traditional Chinese medicine extract nano slow-release mixture, and after sterilization, a wet wipe, spray, gel or ointment type external traditional Chinese medicine is prepared.

[0110] The traditional Chinese medicine prepared in this embodiment is used by 20 subjects for 1 month, and the related research is carried out, and the results are shown in the following table:

[0111]

[0112]

[0113] From the above research results, it can be seen that the expected purpose of smooth breathing is achieved.

[0114] Comparative Example 1

[0115] This comparative example provides a multi-effect traditional Chinese medicine formula and its preparation method, comprising the following components by weight:

[0116] 12 portions of Platycodon grandiflorus;

[0117] Scutellaria baicalensis 3 parts;

[0118] 6 servings of mint;

[0119] Bupleurum chinense 6 parts;

[0120] 6 copies of the Hundred-part series;

[0121] One part Angelica dahurica;

[0122] 0.5 parts fennel seeds;

[0123] Sandalwood 0.1 parts;

[0124] Licorice 3 parts;

[0125] Six portions of white magnolia flowers.

[0126] And it is prepared by the following method:

[0127] Step 1: Add Platycodon grandiflorus, Scutellaria baicalensis, Mentha haplocalyx, Bupleurum chinense, Stemona japonica, Angelica dahurica, Foeniculum vulgare, Sandalwood, Glycyrrhiza uralensis, and Magnolia officinalis to an ultra-fine pulverizer and pulverize to obtain a traditional Chinese medicine powder with a particle size of 1000-2000nm.

[0128] Step 2: Mix the Chinese herbal powder obtained in Step 1 with PEG200 using a mixer at a stirring speed of 100 r / min for 80 min. The mass ratio of PEG200 to Chinese herbal powder is 7:3 to form a liquid-phase Chinese herbal mixture. Place the mixture in a heatable container and heat it to 75°C to obtain a liquid-phase mixture.

[0129] Step 3: Dissolve the liquid mixture obtained in Step 2 with water and ethanol in a mass ratio of 1:2:2. Extract the mixture using a supercritical carbon dioxide extraction device at 45℃ and 6.5MPa. The extract is then extracted by water distillation at 120℃ to obtain the traditional Chinese medicine extract.

[0130] Step 4: Add lecithin to 30 parts of the Chinese herbal extract obtained in Step 3, then mix it evenly with 68 parts of polyethylene glycol, 1.5 parts of chitosan and 0.5 parts of nano silica, heat to 90℃ and stir for 30 minutes to obtain a nano sustained-release mixture of Chinese herbal extract. The mass of lecithin is 5.5% of the total mass of the Chinese herbal extract and polyethylene glycol.

[0131] Step five: adding azone to the nano-sustained release mixture of the traditional Chinese medicine extract prepared in step four, the mass of the azone being 2% of the mass of the nano-sustained release mixture of the traditional Chinese medicine extract, and after sterilization, preparing a wet wipe, spray, gel or ointment type external use traditional Chinese medicine.

[0132] After using the traditional Chinese medicine prepared in this example for one month, a related investigation was conducted on 20 subjects, and the results are shown in the following table:

[0133]

[0134] The specific embodiments described herein are merely illustrative of the spirit of the present application. Those skilled in the art of the present application can make various modifications or supplements to the described specific embodiments or replace them with similar ways, but will not deviate from the spirit of the present application or exceed the scope defined by the appended claims.

Claims

1. A multi-functional traditional Chinese medicine formula for promoting smooth breathing, comprising principal, assistant, adjuvant, and guiding herbs, characterized in that: The principal herbs include Platycodon grandiflorus and Scutellaria baicalensis; the assistant herbs include Mentha haplocalyx and Bupleurum chinense; the adjuvant herbs include Stemona japonica, Angelica dahurica, Foeniculum vulgare, and Santalum album; and the guiding herbs include Glycyrrhiza uralensis and Magnolia officinalis.

2. The multi-effect traditional Chinese medicine formula for promoting smooth breathing as described in claim 1, characterized in that: The traditional Chinese medicine formula includes the following components in parts by weight: Platycodon grandiflorus 8-16 parts; Scutellaria baicalensis 2-4 parts; 2-10 servings of mint; Bupleurum chinense 2-10 parts; 4-8 copies of Hundred Stemona; Angelica dahurica 0.5-2 parts; 0.1-1 part fennel seeds; Sandalwood 0.05-0.2 parts; Licorice 1-5 parts; 2-10 portions of white magnolia.

3. The multi-effect traditional Chinese medicine formula for promoting smooth breathing as described in claim 2, characterized in that: The traditional Chinese medicine formula includes the following components in parts by weight: 12 portions of Platycodon grandiflorus; Scutellaria baicalensis 3 parts; 6 servings of mint; Bupleurum chinense 6 parts; 6 copies of the Hundred-part series; One part Angelica dahurica; 0.5 parts fennel seeds; Sandalwood 0.1 parts; Licorice 3 parts; Six portions of white magnolia flowers.

4. A method for preparing a multi-effect traditional Chinese medicine formula for smooth breathing as described in any one of claims 1-3, characterized in that, Includes the following steps: Step 1: Add Platycodon grandiflorus, Scutellaria baicalensis, Mentha haplocalyx, Bupleurum chinense, Stemona japonica, Angelica dahurica, Foeniculum vulgare, Sandalwood, Glycyrrhiza uralensis, and Magnolia officinalis to an ultra-fine pulverizer and pulverize to obtain a traditional Chinese medicine powder with a particle size of 1000-2000nm. Step 2: Mix the Chinese herbal powder obtained in Step 1 with PEG200 using a mixer for 70-90 minutes to form a liquid-phase Chinese herbal mixture. Place the mixture in a heatable container and heat it to 70-80°C. Then, use a high-speed shearing machine to shear it at a speed of 3000-5000 r / min for 60-1200 minutes to obtain a liquid-phase mixture. The particle size of the Chinese herbal particles in the liquid-phase mixture is 200-800 nm. Step 3: Dissolve the liquid mixture obtained in Step 2 with water and ethanol, and extract it using a supercritical carbon dioxide extraction device at 40-50℃ and 6-7MPa. The extract is then extracted by water distillation at 100-150℃ to obtain the Chinese herbal extract. Step 4: Mix the Chinese herbal extract obtained in Step 3, polyethylene glycol, chitosan and nano silica evenly, heat to 90°C and stir for 30 minutes to obtain a nano sustained-release mixture of Chinese herbal extract. Step 5: Add azone to the nano-sustained-release mixture of Chinese herbal extracts obtained in Step 4, and after aseptic treatment, prepare it into a topical Chinese herbal medicine in the form of wipes, sprays, gels or ointments.

5. The preparation method according to claim 4, characterized in that: In step two, the mass ratio of PEG200 to the traditional Chinese medicine powder is 7:3, and the stirring speed of the mixer is 100 r / min.

6. The preparation method according to claim 4, characterized in that: In step three, the mass ratio of the liquid mixture, water, and ethanol is 1:2:

2.

7. The preparation method according to claim 4, characterized in that: Before mixing the Chinese herbal powder with PEG200 in step two, vitamin E and cyclodextrin are added sequentially; the amount of vitamin E is 1-1.2% of the total mass of the Chinese herbal powder, and the amount of cyclodextrin is 0.2-2.5% of the total mass of the Chinese herbal powder.

8. The preparation method according to claim 4, characterized in that: In step four, lecithin is also added to the herbal extract, and the mass of lecithin is 5-6% of the total mass of the herbal extract and polyethylene glycol.

9. The preparation method according to claim 4, characterized in that: In step four, the components are mixed in the following proportions by weight: 30 parts of traditional Chinese medicine extract, 68 parts of polyethylene glycol, 1.5 parts of chitosan, and 0.5 parts of nano-silica.

10. The preparation method according to claim 4, characterized in that: In step five, the mass of azone is 1-3% of the mass of the nano-sustained-release mixture of traditional Chinese medicine extract.

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