Traditional Chinese medicine composition for treating lung cancer and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating lung cancer and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following substances in parts by weight: 1-15 parts of semen brassicae, 1-15 parts of pinellia ternate, 1-20 parts of walnut kernels, 1-15 parts of pseudo-ginseng, 1-15 parts of puffball, 1-15 parts of cortex moutan, 1-10 parts of asarum, 1-10 parts of radix paeoniae rubra, 1-10 parts of houttuynia cordata, 1-10 parts of curcuma zedoary, 1-10 parts of rhizoma sparganii, 1-10 parts of cowherb seed, 1-10 parts of paris polyphylla, 1-10 parts of codonopsis pilosula, 1-10 parts of rhizoma polygonati and 1-20 parts of pyrola. According to the invention, through accurate compatibility and combination of the whole formula, the symptoms are treated by eliminating pathogenesis such as warming and dissipating cold evil, breaking swelling and removing kernels, the root causes are treated by eliminating pathogenesis such as promoting blood circulation to remove blood stasis, regulating qi and enriching blood, tonifying kidney and reducing phlegm, and both symptoms and root causes are treated.

Description

Technical Field

[0001] This invention relates to traditional Chinese medicine compositions, specifically to a traditional Chinese medicine composition for treating lung cancer and its preparation method. Background Technology

[0002] Lung cancer is a malignant tumor originating from the bronchial mucosa or glands of the lungs. It is one of the fastest-growing malignant tumors in terms of incidence and mortality, posing a significant threat to public health and life. The main causes of lung cancer are external environmental factors, but weakened immunity within the body also greatly increases the risk. Lung cancer is highly prone to distant metastasis in its early stages, spreads widely throughout the body, and easily triggers chest and cardiovascular diseases. Current treatments for lung cancer primarily include chemotherapy, radiotherapy, targeted therapy, and surgical resection. While surgery can remove the tumor, residual cancer cells, regional lymph node metastases, or tumor emboli in blood vessels may remain, resulting in a very high recurrence and metastasis rate. With the deepening of research in traditional Chinese medicine, more and more Chinese herbal formulas are being used as adjuvant therapy for lung cancer, hoping to improve patients' quality of life and survival by regulating the body's immune function, reducing chemotherapy side effects, and inhibiting tumor growth. Summary of the Invention

[0003] To address the aforementioned problems, this invention proposes a traditional Chinese medicine composition for treating lung cancer and its preparation method.

[0004] To achieve the above objectives, the present invention is implemented through the following technical solution: A traditional Chinese medicine composition for treating lung cancer comprises the following substances in parts by weight: 1-15 parts white mustard seed, 1-15 parts pinellia, 1-20 parts walnut kernel, 1-15 parts notoginseng, 1-15 parts puffball, 1-15 parts peony bark, 1-10 parts asarum, 1-10 parts red peony root, 1-10 parts houttuynia cordata, 1-10 parts turmeric, 1-10 parts sparganium, 1-10 parts vaccaria seed, 1-10 parts Paris polyphylla, 1-10 parts codonopsis, 1-10 parts polygonatum, and 1-20 parts pyrrolizum.

[0005] Furthermore, the traditional Chinese medicine composition for treating lung cancer includes the following substances in parts by weight: 3-10 parts white mustard seed, 3-10 parts pinellia, 10-20 parts walnut kernel, 3-15 parts notoginseng, 3-15 parts puffball, 3-15 parts peony bark, 3-10 parts asarum, 3-10 parts red peony root, 3-10 parts houttuynia cordata, 3-10 parts turmeric, 3-10 parts sparganium, 3-10 parts vaccaria seed, 3-10 parts Paris polyphylla, 3-8 parts codonopsis, 3-10 parts polygonatum, and 10-15 parts pyrrolizum var. sarcodactylis.

[0006] Furthermore, the traditional Chinese medicine composition for treating lung cancer comprises the following substances in parts by weight: 5 parts white mustard seed, 8 parts pinellia tuber, 15 parts walnut kernel, 8 parts notoginseng, 5 parts puffball, 10 parts peony bark, 8 parts asarum, 5 parts red peony root, 5 parts houttuynia cordata, 10 parts turmeric, 10 parts sparganium rhizome, 10 parts vaccaria seed, 5 parts Paris polyphylla, 8 parts codonopsis root, 10 parts polygonatum rhizome, and 15 parts pyrrolizum herb.

[0007] This invention also proposes a method for preparing a traditional Chinese medicine composition for treating lung cancer, comprising the following steps: (1) Prepare white mustard seed, pinellia, walnut kernel, notoginseng, puffball, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum and deer antler grass. Select the above medicinal materials and remove impurities, moldy and insect-infested parts. (2) Grind Panax notoginseng and Lycoperdon perlatum into nano-sized powder with a particle size of 1-100 nm for later use; (3) Chop white mustard seed, pinellia, walnut kernel, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum rhizome and deer antler grass into 1-3 cm pieces, soak them in 1-2 times the volume of water for 0.5-1 h, freeze the herbs and water into ice, and keep the frozen herbs for 1-5 h; (4) Take 5-8 times the volume of water of the medicinal material and heat it to boiling. Add the frozen medicinal material while the water is boiling and boil for 0.5-1h. Filter to obtain the first filtrate. Add 3-5 times the volume of water of the medicinal material to the filter residue and boil for 1-2 times. Filter and combine the obtained filtrate with the first filtrate to obtain the primary extract. (5) Add the Tianqi and Mabo powder obtained in step 1 to the primary extract and stir to mix evenly to obtain a mixture. Reflux the mixture to concentrate it and obtain the decoction or paste of the traditional Chinese medicine composition of the present invention.

[0008] Furthermore, in step (5), the reflux concentration is directly heated and refluxed into a mixture, and the heating temperature is 100-120℃.

[0009] Furthermore, the concentrated Chinese medicine composition described in step (5) is dried at 40-60°C to obtain Chinese medicine composition granules.

[0010] Furthermore, the traditional Chinese medicine composition can be prepared by adding excipients into one or more of the following: compound preparation, capsule, tablet, powder, and pill.

[0011] This invention discloses a traditional Chinese medicine composition for treating lung cancer and its preparation method, the beneficial effects of which are: In this invention's formula, Pinellia ternata dries dampness, resolves phlegm, relieves nausea and vomiting, and dissipates lumps and nodules, thus regulating the thick, yellow, sticky phlegm caused by lung heat. White mustard seed, Panax notoginseng, and Lycoperdon perlatum can eliminate sore throat and clear inflammation. The combined effect of these herbs disperses nodules, clears the lungs, and resolves phlegm; therefore, Pinellia ternata, white mustard seed, and Panax notoginseng are the principal herbs. Red peony root and Houttuynia cordata have analgesic, anti-inflammatory, anti-ulcer, antibacterial, and antipyretic effects, serving as adjuvant herbs. Sparganium rhizome is used to regulate qi, while Curcuma zedoaria, Vaccaria segetalis, and Paris polyphylla are used to invigorate blood. The four herbs used together are essential for invigorating blood, removing blood stasis, reducing swelling, breaking up blood stasis, and regulating qi. Ganoderma lucidum... Codonopsis pilosula also enters the blood level, promoting blood circulation, removing blood stasis, and nourishing and stopping bleeding; it is a qi-regulating herb in the blood. Moutan bark removes masses and hard masses, protects the myocardium, and prevents complications caused by lung cancer. Peach kernel breaks up masses and lumps. These 10 herbs are mainly used to eliminate the pathogenesis and are all assistant herbs. Prolonged illness can affect the kidneys, so patients with this disease often also have kidney deficiency. Therefore, Astragalus membranaceus, Polygonatum sibiricum, and Pyrola rotundifolia are used to replenish qi and strengthen the exterior, invigorate qi and nourish the kidneys, moisten the lungs and strengthen the lungs, and prevent dry cough. Asarum relieves pain. The whole formula is used together to treat the symptoms by warming and dispersing cold pathogens, breaking up swelling and removing lumps, etc., to eliminate the cause of the disease. It also treats the root cause by promoting blood circulation, removing blood stasis, regulating qi and nourishing blood, nourishing the kidneys and resolving phlegm, etc., thus treating both the symptoms and the root cause. Detailed Implementation

[0012] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be clearly and completely described below with reference to embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0013] Lungs: White mustard seed is warm in nature and pungent in taste. It warms the lungs, resolves phlegm, promotes qi circulation, disperses nodules, unblocks meridians, and relieves pain. This invention uses a small amount of white mustard seed, which can relieve pain and moisten the lungs. When used together with Pinellia ternata, it can better eliminate lung cancer. Pinellia ternata contains a large amount of volatile oil, amino acids, trace elements, etc., and can dry dampness and resolve phlegm; relieve nausea and vomiting; and dissipate nodules. It is mainly used for cough and asthma with excessive phlegm, goiter and phlegm nodules; carbuncles and boils. It has an inhibitory effect on tumor cells. Pinellia ternata enters the lung meridian and can directly act on the lungs, effectively eliminating lung cancer cells. The β-sitosterol and its analogues also have anti-tumor effects. It can also significantly promote the gradual shedding of cancer cells, causing the cancer to shrink or disappear. The Pinellia ternata used in this invention is selected from bamboo sap Pinellia ternata, processed Pinellia ternata, and ginger Pinellia ternata. Walnut kernel is warm in nature and sweet in taste. It mainly enters the lung and kidney meridians. It has the effects of strengthening the stomach, nourishing blood, moistening the lungs, and nourishing the spirit. Panax notoginseng is warm in nature and sweet and slightly bitter in taste. It disperses blood stasis, stops bleeding, reduces swelling and relieves pain. It can treat hemoptysis caused by lung cancer. Calculus root is pungent, neutral, and non-toxic. It contains protein amino acids, casein, urea, ergosterol, lipids, and calculin. It also contains phosphate, sodium, aluminum, magnesium, silicic acid, and sulfates. It clears the lungs, soothes the throat, detoxifies, and stops bleeding. It is mainly used for sore throat, cough with loss of voice, hemoptysis, and epistaxis.

[0014] Myocardium: Moutan bark clears heat and cools blood, invigorates blood circulation and removes blood stasis, and enters the heart, liver, kidney, and lung meridians; it has the effect of improving immunity and resisting cardiovascular diseases, and can effectively protect against myocarditis, cardiovascular and other complications caused by lung cancer.

[0015] Analgesia: Asarum enters the lung, kidney, and heart meridians. Its volatile oil has significant central nervous system depressant effects, possessing sedative and analgesic properties. Lung cancer itself causes excruciating pain; this new product can reduce patient pain and also improve the body's metabolic function. Asarum can relax bronchial smooth muscle, thus exhibiting an anti-asthmatic effect.

[0016] Anti-inflammatory: Red peony root has anti-inflammatory, anti-ulcer, analgesic, and sedative effects, and can also treat lung qi stagnation and abdominal masses; Houttuynia cordata enters the lung meridian and has the effects of eliminating carbuncles and draining pus, promoting diuresis and reducing swelling, and relieving strangury. It has antibacterial and antiviral effects, can improve the body's immunity, and also has analgesic, antitussive, hemostatic, and calcium-regenerating properties, promoting tissue regeneration and wound healing.

[0017] Curcuma zedoaria is a blood-activating and tonifying herb that breaks up blood stasis, promotes qi circulation, eliminates stagnation, and relieves pain. It is primarily used to treat abdominal masses, abdominal distension and pain, indigestion, amenorrhea due to blood stasis, postpartum abdominal pain due to blood stasis, and pain from falls. Curcuma zedoaria contains curcuma oil, which has anti-tumor properties. Besides directly killing tumor cells, curcuma oil can enhance the immunogenicity of tumor cells, thereby inducing or promoting the body's immune rejection response to tumors. It also has a protective effect on the liver and kidneys, maintaining the balance of various organs in the body. Sparganium rhizome, a blood-activating herb, when used in combination with curcuma zedoaria, can effectively eliminate lung tumor cells. Vaccaria segetalis is a blood-activating herb that promotes blood circulation, disperses stagnation, breaks up qi stagnation, and promotes blood flow. It can significantly prolong clotting time and reduce blood viscosity, thereby increasing blood flow in the body, accelerating the transport of metabolic substances, and improving metabolism, which is beneficial for the dissipation of lung cancer cells. Paris polyphylla has the functions of clearing heat and detoxifying, reducing swelling and relieving pain, and can also effectively eliminate cancer cells.

[0018] Nourishing properties: Sweet, neutral. Enters the heart, lung, liver, and kidney meridians. Primarily treats general weakness, cough, asthma, insomnia, indigestion, and malignant tumors. Ganoderma lucidum is a tonic, strengthening the body, nourishing the kidneys and blood, and improving immune function. Codonopsis pilosula has the effects of tonifying the middle energizer and replenishing qi, strengthening the spleen and benefiting the lungs, and is used for spleen and lung deficiency. Polygonatum sibiricum has the functions of tonifying qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys. It is used to treat spleen and stomach weakness, fatigue, dry mouth and poor appetite, dry cough due to lung deficiency, insufficient essence and blood, and internal heat and thirst. This invention mainly uses Polygonatum sibiricum. Pyrola rotundifolia is used to stop hemoptysis and can treat persistent cough.

[0019] The following are the formulations of each embodiment and the corresponding comparative examples, as shown in Table 1:

[0020] Example 9 A method for preparing a traditional Chinese medicine composition for treating lung cancer includes the following steps: (1) Prepare white mustard seed, pinellia, walnut kernel, notoginseng, puffball, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum and deer antler grass according to the component table of Examples 1-8. Select the above medicinal components and remove impurities, moldy and insect-infested parts. (2) Grind Panax notoginseng and Lycoperdon perlatum into nano-sized powder with a particle size of 80-100 nm for later use; (3) Chop white mustard seed, pinellia, walnut kernel, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum rhizome and deer antler grass into 1-3 cm pieces, soak them in 2 times the volume of water for 1 hour, freeze the herbs and water into ice, and keep the frozen herbs for 2 hours. (4) Take 5 times the volume of water of the medicinal material components and heat it to boiling. Add the frozen medicinal material while the water is boiling and boil for 1 hour. Filter to obtain the first filtrate. Add 5 times the volume of water of the medicinal material components to the filter residue and boil twice. Filter and combine the obtained filtrate with the first filtrate to obtain the initial extract. (5) Add the Tianqi and Mabo powder obtained in step 1 to the initial extract and stir to mix evenly to obtain a mixture. Heat the mixture directly to reflux at a temperature of 100°C and concentrate it to a thick decoction to obtain the Chinese herbal composition decoctions of the formulations of Examples 1-8.

[0021] Example 10

[0022] A method for preparing a traditional Chinese medicine composition for treating lung cancer includes the following steps: (1) Prepare white mustard seed, pinellia, walnut kernel, notoginseng, puffball, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum and deer antler grass according to the component table of Example 1. Select the above medicinal components and remove impurities, moldy and insect-infested parts. (2) Grind Panax notoginseng and Lycoperdon perlatum into nano-sized powder with a particle size of 80-100 nm for later use; (3) Chop white mustard seed, pinellia, walnut kernel, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum rhizome and deer antler grass into 1-3 cm pieces, soak them in 1 volume of water for 1 hour, freeze the herbs and water into ice, and keep the frozen herbs for 2 hours. (4) Take 8 times the volume of water of the medicinal material components and heat it to boiling. Add the frozen medicinal material while the water is boiling and boil for 1 hour. Filter to obtain the first filtrate. Add 3 times the volume of water of the medicinal material components to the filter residue and boil twice. Filter and combine the obtained filtrate with the first filtrate to obtain the initial extract. (5) Add the Tianqi and Mabo powder obtained in step 1 to the primary extract and stir to mix evenly to obtain a mixture. Heat the mixture directly under reflux at a temperature of 100°C and concentrate it into a thick paste. Dry the concentrated Chinese medicine composition paste at 40-60°C to obtain Chinese medicine composition granules.

[0023] Comparative Example 1 A traditional Chinese medicine composition for treating lung cancer was prepared by concentrating the components according to the formulation of Comparative Example 1 and the preparation method of Example 9 to obtain a decoction of the traditional Chinese medicine composition.

[0024] Comparative Example 2 A traditional Chinese medicine composition for treating lung cancer was prepared by concentrating the components according to the formulation of Comparative Example 2 and the preparation method of Example 9 to obtain a decoction of the traditional Chinese medicine composition.

[0025] Comparative Example 3 A traditional Chinese medicine composition for treating lung cancer, prepared by concentration according to the component formulation of Comparative Example 3 and the preparation method of Example 9, yields a decoction of the traditional Chinese medicine composition.

[0026] Comparative Example 4 A traditional Chinese medicine composition for treating lung cancer was prepared by concentrating the components according to the formulation of Comparative Example 4 and the preparation method of Example 9 to obtain a decoction of the traditional Chinese medicine composition.

[0027] Comparative Example 5 A traditional Chinese medicine composition for treating lung cancer is prepared by conventional heating and decocting for 2-3 hours according to the component formula of Comparative Example 5, and then concentrating to obtain the traditional Chinese medicine composition decoction of the component formula of Comparative Example 5.

[0028] Comparative Example 6 A traditional Chinese medicine composition for treating lung cancer is prepared by conventional heating and decocting for 2-3 hours according to the component formula of Example 1, and then concentrating the decoction to obtain the traditional Chinese medicine composition.

[0029] Experimental Design Adult mice of the same size were selected and lung cancer models were constructed by subcutaneous injection of EGFR-mutated A549 lung cancer cell line. They were labeled as groups A, B, C, and D, respectively. Group A was the blank control group, which was given physiological saline for anti-cancer treatment. Groups B and C were given different anti-cancer drugs to be tested. Drug administration: A blank control group was given an equal volume of physiological saline, administered by gavage once daily (10g / kg). Group B received gefitinib as part of standard treatment; Group C was administered the herbal decoctions of Examples 1-8 of the present invention by gavage once a day (10g / kg); the groups were C-1, C-2, C-3, C-4, C-5, C-6, C-7, C-8, and C-9, respectively. Group D was administered the decoction of the traditional Chinese medicine composition of Comparative Examples 1-6 of the present invention by gavage once a day (10g / kg); the groups were D-1, D-2, D-3, D-4, D-5, and D-6, respectively.

[0030] The mice were observed for 12 consecutive weeks. Each week after drug administration, the size and weight of the tumors were measured, and the survival status of the mice, such as changes in weight and mobility, was observed. Tumor size and volume formula: V = length (mm) × width (mm) 2 / 2.

[0031] The results are shown in Table 2:

[0032] As shown in Table 2, the tumor volume of the experimental group (Group B) increased by 15.19% after administration of the targeted drug gefitinib, which effectively controlled the growth of lung cancer volume.

[0033] In the experimental group (Group C), the tumor volume growth was effectively controlled to below 50-60% after using the traditional Chinese medicine composition prepared in this invention, demonstrating a significant tumor-inhibiting effect. In particular, in Example 1, the tumor volume growth was only 53.41%, showing a remarkable effect. This indicates that the traditional Chinese medicine composition of this invention has a significant inhibitory effect on lung cancer tumors and can slow down tumor growth.

[0034] As can be seen from the experimental group (Group D), although there is a certain therapeutic effect in the absence of white mustard seed, puffball, asarum, turmeric and deer antler grass, the effect is not good. This shows that the formula of the traditional Chinese medicine composition of the present invention has a significant effect through the precise compatibility of each component.

[0035] As can be seen from experimental groups D-6 and C-1, the two have the same formula, but due to the different preparation methods, the tumor inhibition of group D-6 was significantly lower than that of group C-1 after administration, indicating that the preparation method of the present invention combined with the formula has a better therapeutic effect on lung cancer.

[0036] Example 11 Typical Case [Case 1] Patient Gao, female, 66 years old, diagnosed with malignant lung tumor (right lung adenocarcinoma), assessed as cT2N3M0, stage IIIB based on relevant examinations. Immunohistochemistry: CK(+), P40(-), Napsin A(-), CgA(-), TTF-1(+), Ki-67 (60%+), p40(-); Genetic testing results: EGFR-L858 mutation. Based on the genetic testing results, she received targeted therapy with gefitinib, which reduced the tumor size from 5.4cm×2.6cm to 1.3cm×1.4cm. However, after 13 months of treatment, resistance to the targeted drug developed, and the tumor size increased to 6.1cm×3.0cm. Clinical symptoms: cough, sputum production, fatigue, accompanied by chest tightness, cold extremities, aversion to cold, poor appetite, occasional irritability, poor sleep, and loose stools 1-2 times daily. Physical examination: pale and dark tongue with a white, greasy coating, and a deep, wiry pulse.

[0037] The decoction of the traditional Chinese medicine composition from Example 1, obtained in Example 9 of this invention, was used for treatment. After 28 days of treatment, the patient's mental state improved, cough and sputum decreased, sputum became clearer and thinner, increased in quantity, and easier to expel. Appetite improved, and symptoms such as fatigue, chest tightness, aversion to cold, and cold limbs were relieved. The patient's mood was more cheerful than before, and bowel movements were 3-4 times daily with loose stools. The tongue and pulse remained largely unchanged. The prescription was not changed, and treatment continued for another 4 months.

[0038] During treatment, the tumor size was monitored monthly. In the first month, the tumor size shrank by 12.31% compared to the average, and the patient's symptoms such as cough and fatigue further improved, so treatment continued as before. In the second month, the tumor shrank to 2.0cm × 1.3cm. In the fourth month, the tumor shrank to 1.3cm × 1.4cm, and subsequent monthly monitoring showed no significant increase or rebound in tumor size until 13 months of medication, when the patient developed resistance to the targeted drug, and the tumor grew again to 6.1cm × 3.0cm.

[0039] [Case 2] Patient Li, male, 36 years old. He presented with enlarged right hilum, a soft tissue mass (4.3cm × 2.9cm) in the right upper lung, and multiple nodules in both lungs. Pathological examination via lung biopsy confirmed "small cell lung cancer". Clinical symptoms included cough, occasional hemoptysis, fatigue, chills, lower back pain, cold extremities, depression, fair appetite and sleep, and normal bowel movements. Physical examination revealed a pale, dark tongue with teeth marks on the edges, a white, greasy coating, and a thready, wiry pulse.

[0040] The decoction of traditional Chinese medicine composition obtained from Example 1 of this invention, along with etoposide + cisplatin, was used for treatment for 2 months. Follow-up examination showed that the soft tissue mass in the upper right lung had shrunk (2.3cm × 2.1cm). During this period, the prescription was slightly adjusted according to the discomfort symptoms. Chest CT was performed every 2 months. The mass size was 1.7cm × 1.5cm, 1.2 × 0.9cm, and 0.6cm × 0.6cm in three consecutive examinations, respectively. The tumor steadily shrank, the patient's physical condition improved significantly, cough was relieved, appetite and sleep improved, the tongue was pale red with fewer teeth marks and a thin white coating, and the pulse was gentle.

[0041] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of the invention. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0042] Finally, it should be noted that the embodiments disclosed in this invention are merely preferred embodiments of this invention and are only used to illustrate the technical solutions of this invention, not to limit it. Although this invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this invention.

Claims

1. A traditional Chinese medicine composition for treating lung cancer, characterized in that: The following substances are included in the following proportions by weight: white mustard seed 1-15 parts, pinellia 1-15 parts, walnut kernel 1-20 parts, notoginseng 1-15 parts, puffball 1-15 parts, peony bark 1-15 parts, asarum 1-10 parts, red peony root 1-10 parts, houttuynia cordata 1-10 parts, turmeric 1-10 parts, sparganium 1-10 parts, vaccaria seed 1-10 parts, Paris polyphylla 1-10 parts, codonopsis pilosula 1-10 parts, polygonatum sibiricum 1-10 parts, and deer antler grass 1-20 parts.

2. The traditional Chinese medicine composition for treating lung cancer according to claim 1, characterized in that: The following substances are included in parts by weight: white mustard seed 3-10 parts, pinellia 3-10 parts, walnut kernel 10-20 parts, notoginseng 3-15 parts, puffball 3-15 parts, peony bark 3-15 parts, asarum 3-10 parts, red peony root 3-10 parts, houttuynia cordata 3-10 parts, turmeric 3-10 parts, sparganium 3-10 parts, cowherb seed 3-10 parts, Paris polyphylla 3-10 parts, codonopsis pilosula 3-8 parts, polygonatum sibiricum 3-10 parts, and deer antler grass 10-15 parts.

3. The traditional Chinese medicine composition for treating lung cancer according to claim 2, characterized in that: The following substances are included in the following proportions by weight: 5 parts white mustard seed, 8 parts pinellia, 15 parts walnut kernel, 8 parts notoginseng, 5 parts puffball, 10 parts peony bark, 8 parts asarum, 5 parts red peony root, 5 parts houttuynia cordata, 10 parts turmeric, 10 parts sparganium, 10 parts vaccaria seed, 5 parts Paris polyphylla, 8 parts codonopsis, 10 parts polygonatum, and 15 parts pyrrolizum var. sarcodactylis.

4. A method for preparing a traditional Chinese medicine composition for treating lung cancer according to any one of claims 1-3, characterized in that: Includes the following steps: (1) Prepare white mustard seed, pinellia, walnut kernel, notoginseng, puffball, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum and deer antler grass. Select the above medicinal materials and remove impurities, moldy and insect-infested parts. (2) Grind Panax notoginseng and Lycoperdon perlatum into nano-sized powder with a particle size of 1-100 nm for later use; (3) Chop white mustard seed, pinellia, walnut kernel, peony bark, asarum, red peony root, houttuynia cordata, turmeric, sparganium, vaccaria seed, Paris polyphylla, codonopsis, polygonatum rhizome and deer antler grass into 1-3 cm pieces, soak them in 1-2 times the volume of water for 0.5-1 h, freeze the herbs and water into ice, and keep the frozen herbs for 1-5 h; (4) Take 5-8 times the volume of water of the medicinal material and heat it to boiling. Add the frozen medicinal material while the water is boiling and boil for 0.5-1h. Filter to obtain the first filtrate. Add 3-5 times the volume of water of the medicinal material to the filter residue and boil for 1-2 times. Filter and combine the obtained filtrate with the first filtrate to obtain the primary extract. (5) Add the Tianqi and Mabo powder obtained in step 1 to the primary extract and stir to mix evenly to obtain a mixture. Reflux the mixture to concentrate it and obtain the decoction or paste of the traditional Chinese medicine composition of the present invention.

5. The method for preparing the traditional Chinese medicine composition for treating lung cancer according to claim 4, characterized in that: The reflux concentration in step (5) is to directly heat the mixture for reflux, and the heating temperature is 100-120℃.

6. The method for preparing the traditional Chinese medicine composition for treating lung cancer according to claim 4, characterized in that: The concentrated Chinese medicine composition described in step (5) is dried at 40-60℃ to obtain Chinese medicine composition granules.

7. A drug for treating lung cancer, characterized in that: The traditional Chinese medicine composition and excipients described in any one of claims 1-3 are prepared as any one or more of the following: compound preparation, capsule, tablet, powder, and pill.

8. The medicament for treating lung cancer according to claim 7, characterized in that: The excipients include any one or more of starch, dextrin, lactose, and microcrystalline cellulose.

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