Formula and preparation method of external spraying agent of quick-acting analgesic tincture

Abstract

The invention discloses a formula and a preparation method of a quick-acting analgesic tincture external spraying agent, and belongs to the technical field of external spraying agents, the quick-acting analgesic tincture external spraying agent comprises the following raw materials in parts by weight: a group A: 25kg of radix clematidis, 20kg of radix saposhnikoviae, 20kg of rhizoma zingiberis, 20kg of radix angelicae, 20kg of rhizoma drynariae, 20kg of notopterygium root, 15kg of corydalis tuber, 15kg of radix aconiti preparata, 15kg of radix aconiti kusnezoffii preparata and 15kg of frankincense preparata; the traditional Chinese medicine is prepared from 15 kilograms of prepared myrrh, 15 kilograms of ligusticum wallichii, 10 kilograms of ephedra, 10 kilograms of asarum, 5 kilograms of saffron crocus (240 kilograms of 15 parts) and 1200 kilograms of ethanol. The group B comprises 15 kilograms of camphor, 5 kilograms of storax oil, 3 kilograms of vanillyl butyl ether and ethanol (the dosage is 300-900% of the total weight of the medicines), the prepared'ten-full-pain quick-napping 'tincture is generally used for various arthralgia pains caused by wind-cold-dampness stasis, and aims at the etiology and symptoms of arthralgia, cold-dampness pains, blood stasis pains, spasm pains and wind-excess channeling pains, medicine symptoms are combined, both symptoms and root causes are taken into consideration, and the traditional Chinese medicine tincture can be used for treating various arthralgia pains caused by wind-cold-dampness stasis. The composition has the advantages of quick transdermal effect, quick effect, broad effect, special effect, safety and convenience, and meets the fast-paced life of modern people and the high requirements on health, high efficiency, convenience and safety. The promotion and popularization of the invention will surely produce great social and economic benefits.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of external spray, and particularly relates to a formula of external spray of a fast-acting analgesic tincture and a preparation method thereof. BACKGROUND

[0002] External application is a traditional Chinese external treatment method, and is one of the most valuable treatment methods and drug forms in traditional Chinese medicine. The ancients have realized that the principle of external treatment is the same as that of internal treatment, and the medicine for external treatment is also the same as that for internal treatment, with the difference being the method. However, due to historical, social and scientific and technological factors, the external treatment method of traditional Chinese medicine has not been well popularized and promoted in China, so that the treatment of traditional Chinese medicine is still mainly based on internal administration of decoction. The oral administration of traditional Chinese medicine decoction is inconvenient to decoct, has a bad smell, is difficult to take, is inconvenient to carry and inconvenient to take, and is not conducive to the development of traditional Chinese medicine. Although the gastrointestinal environment and the skin surface layer are different, the medicine that can be absorbed by the human body in the gastrointestinal tract to achieve a therapeutic effect can also be absorbed by the skin to achieve a therapeutic effect. The treatment principle is transdermal absorption, acupoint stimulation and meridian conduction.

[0003] (1) The skin is separated but the pores are connected, and the skin absorbs medicine from the surface layer to the dermis and the microvessels to enter the circulation to achieve a therapeutic effect. The medicine is transported through the stratum corneum (including intracellular diffusion and intercellular diffusion) and the deep epidermis and dermis, and is absorbed by the capillary network in the lacteal layer of the skin, so as to enter the blood circulation to achieve a therapeutic effect.

[0004] (2) Compared with other parts of the skin, the skin at the acupoint has low impedance, large capacitance and high potential, which is conducive to the penetration and absorption of the medicine.

[0005] (3) Hydration: the water content of the stratum corneum is a function of the relative humidity of the environment. The external application of traditional Chinese medicine tincture can form a closed state in which sweat cannot evaporate and diffuse in the local part, so that the water content of the stratum corneum increases significantly. After hydration, the stratum corneum can be expanded into a porous state, which is easy for the medicine to penetrate, and the penetration rate of the medicine is increased by several times. At the same time, it can also increase the local skin temperature and accelerate blood circulation.

[0006] (4) The tincture is applied to the affected part of the body surface and the acupoint, quickly penetrates the skin, activates neurons, plays a role in drug penetration treatment and acupoint stimulation, and also conducts through the meridian to quickly take effect, which is the reason why the body surface administration often has a quick effect.

[0007] Modern treatment of arthralgia and other diseases caused by wind-cold-dampness and blood stasis, methods and drugs are numerous. These methods mainly use western medicine, injection, acupuncture, massage, cupping and scraping, oral drugs, or plaster, or bath fumigation, these treatment methods have certain curative effect, but all have the problems of complex operation, drug toxicity and side effects, long time-consuming, not conducive to popularization and other unreasonable factors. In recent years, some external use of the invention of the paste has also been used, which is simple, and the drug is self-heating, but it needs to be supplemented by massage, covered with plastic film, the skin is hot and irritating, the heating time is short, the treatment range is narrow, the effect is slow, and the effect is poor.

[0008] In order to solve the above problems existing in the prior art, the present application provides a kind of quick treatment of arthralgia and other diseases caused by wind-cold-dampness and blood stasis The formula and preparation method of the spray tincture of various pains, a quick-acting analgesic tincture external spray prepared by a special preparation method, aiming at the pathogenesis of arthralgia pain, regardless of cold-damp pain, blood stasis pain, spasm pain, wind-dominant pain, all-inclusive, drug and disease in harmony, both the symptoms and the root cause, for arthralgia and other diseases caused by wind-cold-dampness and blood stasis Various pains can be taken quickly. SUMMARY

[0009] The present application aims to provide a kind of quick-acting analgesic tincture external spray formula and preparation method to solve the problems raised in the above background art.

[0010] To achieve the above object, the present application provides the following technical scheme: a kind of quick-acting analgesic tincture external spray formula, by weight, including the following raw materials:

[0011] A group: Wulingxian 25 kg, Fangfeng 20 kg, Ganjiang 20 kg, Baizhi 20 kg, Gushugupu 20 kg, Qianghuo 20 kg, Yansu 15 kg, Zhichuanwu 15 kg, Zhicaowu 15 kg, Zhiluoxiang 15 kg, Zhimugan 15 kg, Mahuang 10 kg, Xixing 10 kg, Zanghonghua 5 kg (15 240 kg), ethanol 1200 kg;

[0012] B group: camphor 15 kg, suohexiangyou 5 kg, eugenol butyl ether 3 kg, ethanol (the amount is 300-900% of the total weight of the above-mentioned drugs).

[0013] Preferably, a preparation process of a quick-acting analgesic tincture external spray, comprising the following steps:

[0014] (1) The "A group" drugs are weighed respectively, and the raw material components are dried, crushed, processed, and crushed to obtain a fine powder with a particle size of more than 40 mesh. The raw material fine powder is mixed uniformly to obtain the first "A group" medicine powder;

[0015] (2) Put the "A component" medicine powder into a container, and add 700 kg of 75% ethanol for soaking (soaking for 10 days in summer and 15 days in winter, and stirring 1-2 times per day); after filtration, add 500 kg of ethanol to the medicine residue for soaking (soaking for 10 days in summer and 15 days in winter, and stirring 1-2 times per day), and then filter.

[0016] Mix the two filtrates together;

[0017] (3) Dissolve 15 kg of camphor in the "B component" with appropriate amount of ethanol, and then add the above filtrate, 5 kg of styrax, and 3 kg of eugenol butyl ether, and stir well; after standing for 72 hours, the supernatant is absorbed by siphon method. According to the use requirement, the "ball bottle" is packaged as a rolling agent, or the "spray bottle" is packaged as a spray agent, or other containers such as "drop bottle" are used for packaging to obtain the finished product. The specification is generally 10-100 ml, and other specifications can be packaged according to market demand.

[0018] Compared with the prior art, the beneficial effects of the present application are:

[0019] The prepared "Shiquan Tongnong" tincture is suitable for various arthralgia caused by wind-cold-dampness and blood stasis, and is aimed at the causes and symptoms of arthralgia, cold-damp pain, blood stasis pain, spasm pain, and wind-dominant pain. The medicine and symptoms are in harmony, the root and branch are considered, the skin is quickly penetrated, the effect is rapid, wide, special, safe and convenient, and meets the high requirements of modern people for fast-paced life, rapid and efficient health and safety. The popularization and application of the present application will certainly produce great social and economic benefits. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0021] The present application provides a formula of a rapid analgesic tincture external use spray agent, which comprises the following raw materials in weight parts:

[0022] A group: 25 kg of Wulingxian, 20 kg of Fangfeng, 20 kg of Ganjiang, 20 kg of Baizhi, 20 kg of Gushugupu, 20 kg of Qianghuo, 15 kg of Yanshu Suo, 15 kg of Zhizhu Wu, 15 kg of Zhilu Huo, 15 kg of Zhilu Ruogan, 15 kg of Chuanxiong, 10 kg of Mahuang, 10 kg of Xi xing, 5 kg of Zanghonghua (15 parts of 240 kg), and 1200 kg of ethanol;

[0023] Group B: camphor 15 kg, styrax 5 kg, methyl eugenol 3 kg, ethanol (300-900% of the total weight of the aforementioned drugs).

[0024] In this embodiment, the preparation process of a fast-acting analgesic tincture external use spray includes the following steps:

[0025] (1) The "A component" drugs are weighed respectively, and the raw material components are dried, crushed, processed, and crushed to obtain fine powder with a particle size of more than 40 mesh. The fine powder of the raw materials is thoroughly mixed to obtain the "A component" drug powder.

[0026] (2) The "A component" drug powder is placed in a container and soaked in 75% ethanol 700 kg (soaked for 10 days in summer and 15 days in winter, stirred 1-2 times a day). After filtration, the residue is soaked in 500 kg of ethanol (soaked for 10 days in summer and 15 days in winter, stirred 1-2 times a day), and then filtered.

[0027] The filtrates from the two times are mixed together;

[0028] (3) The camphor 15 kg in the "B component" is dissolved in an appropriate amount of ethanol and added to the above filtrate, then 5 kg of styrax is added, followed by the addition of 3 kg of methyl eugenol. After stirring, it is left to stand for 72 hours, and then the supernatant is sucked off by siphon method. According to the needs of use, it is packaged as a rolling agent in a "rolling ball bottle", or as a spray in a "spray bottle", or in a "dropping bottle" and other containers to obtain the finished product. The general specification is 10-100 ml, and other specifications can be packaged according to market demand.

[0029] Further, the product is suitable for various pains, such as:

[0030] (1) Pain of arthralgia syndrome: shoulder periarthritis, cervical spondylosis, lumbar disc herniation, sciatica, hyperosteogeny, lumbar muscle strain, synovitis, tendon sheath inflammation, tennis elbow, old cold legs, old cold waist, and other neck, shoulder, waist and leg pain and numbness.

[0031] (2) Pain of injury: pain of chronic injury and pain of various parts of injury.

[0032] (3) Cold stomach pain.

[0033] (4) Dysmenorrhea of cold and blood stasis type in women.

[0034] (5) Frostbite (not broken).

[0035] 3. Method of use

[0036] Apply it to the painful area, three times a day (once in the morning, noon, and evening), and 15 days for a course of treatment, with a 3-day interval between each course.

[0037] Efficacy: 197 patients were verified, all took a minute to see the rapid effect of the rapid effect. According to 15 days as a course (course interval stop 3 days), among them, 136 cases of clinical cure (1-4 courses of medication, follow-up for 6-13 months without recurrence) accounted for 68%; 33 cases of marked effect (continuous use of 7-15 days, no recurrence within 5 months, recurrence after re-treatment still obtained rapid effect), accounting for 16.75%; 26 cases of effective (not treated according to the course, stopped after seeing effect, relapsed within a month, re-treatment also obtained rapid effect), accounting for 13.2%; 2 cases of invalid (1 case of no effect after 2 times of medication, 1 case of effective after 1 day of medication due to itching), accounting for 0.01%. The total effective 195 cases, accounting for 99%, of which 169 cases were cured, the cure rate was 85.79%. Compared with similar products, it has very obvious advantages in safety, high efficiency, rapid effect, broad spectrum, convenience and other aspects.

[0038] Further,

[0039] Saffron: sweet, flat. Liver, heart meridian. Blood circulation is a commonly used drug.

[0040] Effect: regulating blood and promoting blood circulation, cooling blood and resolving depression, dredging channels, used for women with dysmenorrhea, amenorrhea, postpartum lochia, blood stasis abdominal pain and other symptoms; dispelling blood stasis, reducing blood lipids, analgesic, heart, for blood stasis, mass accumulation, sprains, sores, blood stasis, joint pain, coronary heart disease, angina, thrombosis obliterans, hyperlipidemia, etc.

[0041] Further,

[0042] Ephedra. Xing, bitter, warm. Lung, bladder meridian. Yin, the yang of the sun. Commonly used for colds.

[0043] Effect: 1. Liver wind, sweat, cold, for colds, fever, headache, body aches, no sweat, pulse tightness and other table; 2. Proliferation of lung flatulence, for wind and cold, lung qi obstruction, wheezing cough, chest tightness, asthma. 3. Water swelling, for water swelling, water swelling, wind and pulse floating and other symptoms.

[0044] Further,

[0045] Qiang active: bitter, warm. Bladder, kidney meridian. Yin, the yang of the sun. Internal and external medicine.

[0046] Effect: 1. Xinyan Jietable, cold, for colds, fever, headache, body aches and other symptoms; 2. Wind and dampness, for wind and dampness, joint pain, shoulder and back pain, especially for upper body pain.

[0047] Further,

[0048] Wiling: warm, bitter, salty. Bladder meridian. Can be upgraded, Yin, the yang of the sun. Wind and dampness commonly used drugs.

[0049] Efficacy: 1. Expelling wind and dampness, activating meridians, relieving pain, for rheumatic arthralgia, numbness of limbs, muscle and tendon spasm, joint flexion and extension difficulty; 2. Also for esophageal cancer with swallowing obstruction symptoms, or gastric cancer causing incomplete pyloric obstruction, eliminating mucosal edema, pain of breast cancer and bone malignant tumors.

[0050] Further,

[0051] Radix et Rhizoma Aconiti Praeparata: bitter, hot; has large toxicity. Returns to heart, liver, kidney, spleen meridian. Buoyancy. Warm, pain-relieving commonly used drugs.

[0052] Efficacy: Expelling wind and dampness, warming meridians and relieving pain, for wind-cold-damp arthralgia, joint pain, cold abdominal pain, cold hernia pain, and pain due to injury.

[0053] Further,

[0054] Radix Aconiti: bitter, hot; has large toxicity. Returns to heart, liver, kidney, spleen meridian. Internal and external pain-relieving commonly used drugs.

[0055] Efficacy: Expelling wind and dampness, warming meridians and relieving pain. For wind-cold-damp arthralgia, joint pain, cold abdominal pain, cold hernia pain, and pain due to injury. Expelling wind and dampness, relieving pain, resolving phlegm, and reducing swelling. Treats stroke, headache, cold abdominal pain, phlegm, qi mass, cold dysentery, laryngeal obstruction, and scrofula.

[0056] Further,

[0057] Rhizoma Zingiberis Recens: bitter, hot; returns to spleen, stomach, kidney, heart, lung meridian. Can ascend and descend. Warm, internal and external commonly used drugs.

[0058] Efficacy: Warming the interior, dispersing cold from the middle, for spleen and stomach deficiency cold, cold abdominal pain, vomiting and diarrhea, etc.; restoring yang and unblocking collaterals, for yang deficiency and internal cold, cold limbs, and pulseless yang deficiency; warming the lung and resolving fluid, for cold fluid in the lung, cough and shortness of breath, cold back, and excessive clear and watery sputum; warming the channels and stopping bleeding, for cold and deficiency bleeding, metrorrhagia, and pale complexion, pale tongue, and thin pulse.

[0059] Further,

[0060] Radix Saposhnikoviae: bitter, warm. Returns to bladder, liver, and spleen meridian. Ascend.

[0061] Efficacy: Bitter, warm, and expelling wind and cold, for headache, body pain, and aversion to cold due to external wind-cold; dispelling dampness and relieving pain, for wind-cold-damp arthralgia, itchy and painful joints, and limbs spasm; stopping convulsions, for tetanus, jaw clenching, and convulsions.

[0062] Further,

[0063] Frankincense. bitter, warm. Heart, liver, spleen. Blood circulation is often used.

[0064] Effect: blood, blood, blood, pain, heart, for blood stasis, dysmenorrhea, stomach, rheumatism, injury, carbuncle pain, etc.; swelling, for ulceration, long not closed.

[0065] Further,

[0066] Myrrh. bitter, flat. Heart, liver, spleen. Blood circulation is often used.

[0067] Effect: blood, blood, blood, pain, swelling, muscle, blood lipids. For blood stasis, dysmenorrhea, stomach, injury, carbuncle pain or long ulcer, hyperlipidemia, fatty liver

[0068] Further,

[0069] Asarum. bitter, warm. Heart, lung, kidney. Ascension. Xinyan Jielie, warm, surgical often used.

[0070] Effect: Xinyan Jielie, Jielie, for exogenous wind and cold, fever, headache, body pain, nasal congestion or sometimes clear nasal discharge, etc.; wind and pain, for headache, toothache, rheumatism, etc.; warm and humid, for exogenous wind and cold or cold and humid lung caused by cough and asthma, sputum, etc. And can pass the nasal cavity. Treat rhinitis

[0071] Further,

[0072] Bone fracture. bitter, warm. Liver, kidney. Yang, surgical often used.

[0073] Effect: Yang, kidney, bone, for kidney deficiency, foot, tinnitus, deafness, tooth loose, toothache, chronic diarrhea, etc.; blood, blood, for contusion, injury, injury, etc.; alcohol extract for alopecia areata, vitiligo.

[0074] Further,

[0075] Corydalis. warm, bitter, bitter. Heart, liver, spleen. Ascension and descent. Blood circulation is often used in internal and external surgery.

[0076] Effect: blood, blood, blood, pain, for blood stasis, dysmenorrhea, stomach, rheumatism, injury, carbuncle pain or long ulcer, hyperlipidemia, fatty liver

[0077] Further,

[0078] Angelica. warm, bitter. Lung, large intestine, stomach. Ascension, Yang. Xinyan Jielie, pain often used.

[0079] Efficacy: Xingwen Jiebiao, Qufeng Chushi, Tongqiao Zhitong, for external wind and cold, cold, headache, eyebrow ridge bone pain, nasal congestion, nasal congestion, toothache, breast cancer, brain tumor headache; Xiaozhong Paoyong, for carbuncle sore abscess pain; Dashi Zhidai, for women with cold and wet vaginal bleeding; Blood pressure, for low blood pressure.

[0080] Further,

[0081] Chuanxiong. Xing, Wen. Liver, gallbladder, heart, and uterus. Sheng.

[0082] Efficacy: 1. Lixue Huoxue, Xingqihuayu, for blood stasis and qi stagnation, irregular menstruation, dysmenorrhea, amenorrhea, postpartum abdominal pain, abdominal mass, abdominal pain, chest pain, numbness, sprains and injuries, and sores and abscesses. 2. Qufeng Zhitong, for headache, rheumatic arthralgia, coronary heart disease, angina pectoris, and ischemic vascular disease.

[0083] Further,

[0084] Camphor. Xing, hot, toxic. Heart, spleen. Commonly used in surgery.

[0085] Efficacy: external use, wet and insect killing, warm and pain relieving, external use for scabies, toothache, sprains and injuries, etc.; Kaitong Bimu, for coma, or abdominal pain, etc.

[0086] Further,

[0087] Suhe Xiangyou. Xing, Wen. Heart, spleen. Pediatric, Kaitong commonly used drugs.

[0088] Efficacy: Kaitong Bimu, pain relief, for stroke and phlegm, sudden fainting, chest and abdominal cold pain, convulsions, toothache, unconsciousness, and cold syndrome, and abdominal pain and fullness.

[0089] Further,

[0090] Vanillyl butyl ether. Alias: vanillyl butyl ether, vanillyl butyl ether. Mild hot agent, widely used in weight loss, breast enhancement, beauty and commodity industry.

[0091] The working principle and use process of the present application are as follows:

[0092] The "A component" medicine is weighed and each raw material component is dried, processed, crushed and pulverized to obtain a fine powder with a particle size of 40 mesh or more. The fine powder of each raw material is mixed thoroughly to obtain the "A component" medicine powder. The "A component" medicine powder is put into a container and 700 kg of 75% ethanol is added for soaking (10 days in summer and 15 days in winter, with stirring 1-2 times per day). After filtration, the residue is soaked with 500 kg of ethanol (10 days in summer and 15 days in winter, with stirring 1-2 times per day), and then filtered. The two filtrates are mixed together. 15 kg of camphor in the "B component" is dissolved in an appropriate amount of ethanol and added to the above filtrate. 5 kg of rose oil is then added, followed by 3 kg of eugenol butyl ether. After stirring, the mixture is left to stand for 72 hours. The supernatant is then absorbed by siphoning. According to the use, the "ball bottle" is packaged as a roll-on, or the "spray bottle" is packaged as a spray, or the "drop bottle" is used as a container to obtain the finished product. The general specification is 10-100 ml, and other specifications can be packaged according to market demand.

[0093] The basic principles, main features and advantages of the present application are shown and described above. Those skilled in the art should understand that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. A formulation for a fast-acting analgesic tincture spray, characterized in that, By weight, it includes the following ingredients: Group A: Clematis chinensis 25 kg, Saposhnikovia divaricata 20 kg, dried ginger 20 kg, Angelica dahurica 20 kg, Drynaria fortunei 20 kg, Notopterygium incisum 20 kg, Corydalis yanhusuo 15 kg, processed Aconitum carmichaelii 15 kg, processed Aconitum kusnezoffii 15 kg, processed Boswellia carterii 15 kg, processed Commiphora myrrha 15 kg, Ligusticum chuanxiong 15 kg, Ephedra sinica 10 kg, Asarum heterotropoides 10 kg, saffron 5 kg (15 kg total 240 kg), ethanol 1200 kg; Group B: 15 kg camphor, 5 kg styrax oil, 3 kg vanillyl butyl ether, and ethanol (the amount used is 300-900% of the total weight of the aforementioned drugs).

2. The preparation process of the aforementioned fast-acting analgesic tincture for external application includes the following steps: (1) Weigh each raw material component of the "Component A" drug separately, and dry, pulverize, process and pulverize to obtain fine powder with a particle size of 40 mesh or higher; mix the fine powder of each raw material thoroughly and evenly to obtain the "Component A" drug powder; (2) Place the powder of "Component A" in a container and soak it in 700 kg of 75% ethanol (soak for 10 days in summer and 15 days in winter, stirring 1-2 times a day); after filtration, soak the residue in 500 kg of ethanol (soak for 10 days in summer and 15 days in winter, stirring 1-2 times a day), and then filter. Mix the two filtrates together. (3) Dissolve 15 kg of camphor in "Component B" with an appropriate amount of ethanol, add it to the above filtrate, then add 5 kg of styrax oil, and then add 3 kg of vanillyl butyl ether. Stir well, let stand for 72 hours, and then siphon off the supernatant. Depending on the application, it can be packaged as a roller coating agent in a "ball bottle", or as a spray agent in a "spray bottle", or as a finished product in a "dropper bottle" or other containers. The specifications are generally 10 ml to 100 ml, but can be packaged into other specifications according to market demand.