Formula and preparation method of external orthopedic plaster

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a formula and a preparation method of an external orthopedic plaster, the external orthopedic plaster comprises the following raw materials: scorpio, long-noded pit viper, radix clematidis, safflower, ground beetle, frankincense, myrrh, curcuma zedoary, lindera aggregata, lycopodium clavatum, garden balsam stem, angelica sinensis, eucommia ulmoides, ligusticum wallichii, semen strychni, borneol, camphor, dragon's blood, yellow lead, sesame oil, radix rehmanniae and radix rehmanniae preparata. Various medicinal materials are compatible with one another, both symptoms and root causes are treated according to etiology and pathogenesis of orthopedic diseases, and the traditional Chinese medicine composition has a remarkable curative effect on various orthopedic diseases such as traumatic injury, rheumatism ostalgia and hyperostosis; according to the preparation method, technological parameters such as soaking, frying and mixing are strictly controlled, so that effective components of the medicinal materials are fully extracted and converted, meanwhile, harmful substances are removed, irritation of the plaster to skin is reduced, and safety is improved; the plaster substrate is moderate in viscosity and easy to paste and uncover, and the hardness of the substrate is adjusted by seasons, so that the plaster can adapt to different environments and seasons, and practical application and operation are facilitated.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a formula and preparation method for a topical orthopedic plaster. Background Technology

[0002] In the treatment of orthopedic diseases, topical plasters have become a commonly used clinical treatment method due to their advantages such as direct action on the lesion, ease of use, and few side effects. Currently, most orthopedic plasters use traditional Chinese medicinal herbs that dispel wind and dampness, promote blood circulation, remove blood stasis, relax muscles, and relieve pain as their main ingredients, which are mixed with a base to form a patch preparation.

[0003] In practical applications, the viscosity and hardness of the plaster matrix are easily affected by temperature. It tends to soften and flow in summer and harden and peel off in winter. The plaster's ability to promote transdermal drug absorption relies on a single component and lacks a multi-component design to synergistically enhance transdermal absorption, which affects the efficacy of the drug and is not conducive to practical application and operation. Summary of the Invention

[0004] One objective of this invention is to provide a formulation and preparation method for a topical orthopedic plaster.

[0005] To achieve the above objectives, the technical solution adopted by this invention is as follows: a formula and preparation method for an external orthopedic plaster, comprising the following raw materials: 1-10 parts of whole scorpion, 1-10 parts of white-flowered snake, 1-10 parts of Clematis chinensis, 1-10 parts of safflower, 1-10 parts of earthworm, 1-10 parts of frankincense, 1-10 parts of myrrh, 1-10 parts of turmeric, 1-10 parts of Lycopodium clavatum, 1-10 parts of Clematis armandii, 1-10 parts of Angelica sinensis, 1-10 parts of Eucommia ulmoides, 1-10 parts of Ligusticum chuanxiong, 1-10 parts of Strychnos nux-vomica, 1-10 parts of borneol, 1-10 parts of camphor, 1-10 parts of dragon's blood, 1-10 parts of litharge, and 50-200 parts of sesame oil; the preparation method comprises the following steps:

[0006] Step 1: Place the whole scorpion, white-flowered snake, clematis, safflower, earthworm, frankincense, myrrh, strychnine, lindera, lycopodium, clematis root, angelica, eucommia bark, chuanxiong rhizome, and nux vomica in a container, pour in sesame oil and soak for two days. Then fry over low heat until the herbs turn grayish-black. After cooling, filter out the dregs and collect the oil for later use.

[0007] Step 2: Place the litharge in a container and stir-fry over a low flame until all the moisture has dissipated;

[0008] Step 3: Adjust the dosage of litharge according to the season: for every 500g of medicinal oil, add 250g of litharge in summer, 210g of litharge in winter, and 220g of litharge in spring and autumn;

[0009] Step 4: Heat the obtained medicinal oil to 90℃±5℃, add the treated litharge evenly, and heat while stirring until it foams and forms a black paste. Continue stirring during this process to dissipate the thick smoke.

[0010] Step 5: Pour the black paste into cold water and soak for 3 days, changing the water once a day to remove the fire toxins;

[0011] Step Six: Heat and melt the black ointment used to remove fire toxins, then add borneol, camphor, and dragon's blood powder and stir well.

[0012] Step 7: Spread the melted paste evenly on a thick cloth or kraft paper, then fold and store it.

[0013] Preferably, the temperature of the frying in step one is controlled at 100-150℃, and the frying time is based on the complete carbonization of the medicinal materials, which turn grayish-black.

[0014] Preferably, the stirring speed in step four is 50-100 rpm, and the reaction time until the black paste is formed is 30-60 minutes.

[0015] Preferably, in step five, the cold water soaking temperature is 5-25℃, and the amount of water changed each time is 5-10 times the volume of the black paste.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] (1) This invention uses a formula that combines various medicinal materials to treat the root cause and symptoms of orthopedic diseases. It has significant effects on various orthopedic conditions such as sprains, rheumatic bone pain, and bone hyperplasia. The preparation method strictly controls the process parameters such as soaking, frying, and mixing to ensure the full extraction and transformation of the effective components of the medicinal materials, while removing harmful substances, reducing the skin irritation of the plaster, and improving safety. The plaster matrix has moderate viscosity, making it easy to apply and remove. The matrix hardness can be adjusted according to the season to adapt to different environments and seasons. The finished plaster has good stability and is easy to store and transport. Moreover, the plaster is administered through the skin, which can avoid the stimulation of the gastrointestinal tract, liver, and kidneys caused by oral drugs, reduce adverse reactions, and is convenient to use with high patient compliance. Detailed Implementation

[0018] The present invention will now be further described in conjunction with specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0019] In the description of this invention, it should be noted that directional terms such as "center," "lateral," "longitudinal," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise" are used only to facilitate the description of this invention and to simplify the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and should not be construed as limiting the specific scope of protection of this invention.

[0020] It should be noted that the terms "first" and "second" in the specification and claims of this invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence.

[0021] One preferred embodiment of the present invention provides a formula and preparation method for a topical orthopedic plaster, comprising the following raw materials: 1-10 parts of whole scorpion, 1-10 parts of white-flowered snake, 1-10 parts of Clematis chinensis, 1-10 parts of safflower, 1-10 parts of earthworm, 1-10 parts of frankincense, 1-10 parts of myrrh, 1-10 parts of turmeric, 1-10 parts of Lycopodium clavatum, 1-10 parts of Clematis armandii, 1-10 parts of Angelica sinensis, 1-10 parts of Eucommia ulmoides, 1-10 parts of Ligusticum chuanxiong, 1-10 parts of Strychnos nux-vomica, 1-10 parts of borneol, 1-10 parts of camphor, 1-10 parts of dragon's blood, 1-10 parts of litharge, and 50-200 parts of sesame oil; the preparation method includes the following steps:

[0022] Step 1: Place the whole scorpion, white-flowered snake, clematis, safflower, earthworm, frankincense, myrrh, scutellaria, lindera, lycopodium, clematis root, angelica, eucommia bark, chuanxiong rhizome, and nux vomica in a container, pour in sesame oil and soak for two days. Then fry over low heat until the herbs turn grayish-black. After cooling, filter out the dregs and collect the oil for later use.

[0023] Step 2: Place the litharge in a container and stir-fry over a low flame until all the moisture has dissipated;

[0024] Step 3: Adjust the dosage of litharge according to the season: for every 500g of medicinal oil, add 250g of litharge in summer, 210g of litharge in winter, and 220g of litharge in spring and autumn;

[0025] Step 4: Heat the obtained medicinal oil to 90℃±5℃, add the treated litharge evenly, and heat while stirring until it foams and forms a black paste. Continue stirring during this process to dissipate the thick smoke.

[0026] Step 5: Pour the black paste into cold water and soak for 3 days, changing the water once a day to remove the fire toxins;

[0027] Step Six: Heat and melt the black ointment used to remove fire toxins, then add borneol, camphor, and dragon's blood powder and stir well.

[0028] Step 7: Spread the melted paste evenly on a thick cloth or kraft paper, then fold and store it.

[0029] Step 1: The temperature for frying over a low flame should be controlled at 100-150℃, and the frying time should be until the medicinal materials are completely charred and turn grayish-black.

[0030] Step four: Stir at 50-100 rpm until a black paste is formed. The reaction time is 30-60 minutes.

[0031] Step 5: Soak in cold water at a temperature of 5-25℃, and change the water each time by filling it 5-10 times the volume of the black paste.

[0032] Working principle:

[0033] When used, the formula contains ingredients such as scorpion and white-flowered snake, which have the effects of clearing the meridians and relieving pain, penetrating deep into the affected area to dredge the meridians and blood. Clematis chinensis, Lycopodium clavatum, and Clematis armandii dispel wind and dampness, relax muscles and tendons, and improve joint flexibility. Safflower, frankincense, myrrh, and Ligusticum chuanxiong invigorate blood and remove blood stasis, promote local blood circulation, and dissipate swelling and pain caused by blood stasis. Strychnos nux-vomica disperses nodules, reduces swelling, clears the meridians, and relieves pain, which can enhance the penetration of the medicine. Angelica sinensis and Eucommia ulmoides nourish the liver and kidneys, strengthen tendons and bones, and fundamentally regulate the bones. Borneol and camphor are highly volatile and can promote the transdermal absorption of the medicine. Dragon's blood promotes tissue regeneration and heals sores, accelerating the repair of damage. In the preparation process, sesame oil fully extracts the effective components of the medicinal materials, and litharge reacts chemically with the medicinal oil to form a stable ointment matrix. The amount of litharge is adjusted according to the season to ensure the viscosity and adhesion of the ointment at different temperatures. Soaking in cold water removes the fire toxicity and irritating substances from the ointment. Finished plasters are applied to the skin, allowing the active ingredients to penetrate the skin and reach the affected area directly, thus exerting therapeutic effects such as reducing swelling and pain, relaxing muscles and tendons, and strengthening bones and muscles.

[0034] The basic principles, main features, and advantages of this invention have been described above. Those skilled in the art should understand that this invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely principles of the invention. Various changes and modifications can be made without departing from the spirit and scope of the invention, and all such changes and modifications fall within the scope of the invention as claimed. The scope of protection claimed by this invention is defined by the appended claims and their equivalents.

Claims

1. A formula and preparation method for a topical orthopedic plaster, characterized in that, The raw materials include: 1-10 parts of whole scorpion, 1-10 parts of white-flowered snake, 1-10 parts of clematis root, 1-10 parts of safflower, 1-10 parts of earthworm, 1-10 parts of frankincense, 1-10 parts of myrrh, 1-10 parts of turmeric root, 1-10 parts of lindera root, 1-10 parts of lycopodium root, 1-10 parts of clematis root, 1-10 parts of angelica root, 1-10 parts of eucommia bark, 1-10 parts of chuanxiong rhizome, 1-10 parts of strychnos seed, 1-10 parts of borneol, 1-10 parts of camphor, 1-10 parts of dragon's blood, 1-10 parts of litharge, 50-200 parts of sesame oil, 1-10 parts of raw rehmannia root, and 1-10 parts of prepared rehmannia root; the preparation method includes the following steps: Step 1: Place the whole scorpion, white-flowered snake, clematis, safflower, earthworm, frankincense, myrrh, scutellaria, lindera, lycopodium, clematis root, angelica, eucommia bark, chuanxiong rhizome, strychnos nux-vomica, raw rehmannia root, and prepared rehmannia root into a container, pour in sesame oil and soak for two days. Then fry over low heat until the herbs turn grayish-black. After cooling, filter out the dregs and collect the oil for later use. Step 2: Place the litharge in a container and stir-fry over a low flame until all the moisture has dissipated; Step 3: Adjust the dosage of litharge according to the season: for every 500g of medicinal oil, add 250g of litharge in summer, 210g of litharge in winter, and 220g of litharge in spring and autumn; Step 4: Heat the obtained medicinal oil to 90℃±5℃, add the treated litharge evenly, and heat while stirring until it foams and forms a black paste. Continue stirring during this process to dissipate the thick smoke. Step 5: Pour the black paste into cold water and soak for 3 days, changing the water once a day to remove the fire toxins; Step Six: Heat and melt the black ointment used to remove fire toxins, then add borneol, camphor, and dragon's blood powder and stir well. Step 7: Spread the melted paste evenly on a thick cloth or kraft paper, then fold and store it.

2. The formulation and preparation method of a topical orthopedic plaster as described in claim 1, characterized in that: The temperature of the first step of frying over a low flame is controlled at 100-150℃, and the frying time is based on the complete carbonization of the medicinal materials, which turn grayish-black.

3. The formulation and preparation method of a topical orthopedic plaster as described in claim 1, characterized in that: The stirring speed in step four is 50-100 rpm, and the reaction time until the black paste is formed is 30-60 minutes.

4. The formulation and preparation method of a topical orthopedic plaster as described in claim 1, characterized in that: In step five, the cold water soaking temperature is 5-25℃, and the amount of water changed each time is 5-10 times the volume of the black paste.