Bilirubin extraction-based heating and cooling tank for biological pharmacy

Abstract

The invention relates to the technical field of bilirubin extraction, in particular to a bilirubin extraction-based heating and cooling tank for biological pharmacy, which comprises a tank body, a stirring mechanism is arranged in the tank body, one end of the top of the tank body is communicated with an exhaust pipe, and a plurality of uniformly distributed exhaust holes are formed in the top end of the exhaust pipe. A shielding seat is fixedly mounted at the top of the exhaust pipe, the exhaust pipe is fixedly sleeved with a collecting box, a defoaming mechanism and a pushing mechanism are arranged in the exhaust pipe, and a defoaming agent spraying mechanism is arranged in the collecting box. The device has the beneficial effects that the defoaming mechanism is arranged in the exhaust pipe, when the foam amount exceeds the processing capacity of a defoaming paddle and is sprayed out from the exhaust pipe, the two defoaming plates in the defoaming mechanism pierce and eliminate the foam, and in the process of extracting bilirubin through pig bile in biological pharmacy, the defoaming effect is good. And the problem of bilirubin loss caused by the fact that foam sprayed out of the exhaust pipe carries part of bilirubin is avoided.

Description

Technical Field

[0001] This invention relates to the field of bilirubin extraction technology, specifically to a heating and cooling tank for biopharmaceutical applications based on bilirubin extraction. Background Technology

[0002] Bilirubin is a compound containing multiple pyrrole rings (typical nitrogen-containing heterocyclic structures) linked by methenyl groups to form a chain molecule. In biopharmaceutical manufacturing, bilirubin is typically extracted from animal bile, such as bovine bile, poultry bile, or avian bile. The bilirubin extraction process usually utilizes a heating and cooling tank for the reaction. For example, patent publication CN214937130U, entitled "A Novel Heating and Cooling Tank for Bilirubin Extraction," relates to the field of bilirubin extraction equipment technology, and its main function is to complete the extraction process using a heating and cooling tank.

[0003] However, when extracting bilirubin from pig bile, although pig bile is readily available and has a high bilirubin content, it also contains high levels of mucoproteins and surfactants (such as bile salts). When acidified (pH drops to 3-4), it releases a large amount of CO2 (from carbonate decomposition), resulting in stubborn foam. Typically, heating and cooling tanks are equipped with stirring structures to ensure sufficient reaction of the raw materials. Patent publication CN214937130U also utilizes a combination of a stirring motor and a stirring rod for this purpose. However, mechanical stirring further exacerbates foam generation during bilirubin extraction from pig bile. In existing technologies, some stirring devices also include defoaming paddles to eliminate the generated foam. However, when the amount of foam exceeds the defoaming paddle's processing capacity, the foam is ejected through the exhaust pipe in the heating and cooling tank. This ejected foam carries some bilirubin, resulting in a loss of some bilirubin. Summary of the Invention

[0004] The purpose of this invention is to provide a heating and cooling tank for biopharmaceutical manufacturing based on bilirubin extraction, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a heating and cooling tank for manufacturing biopharmaceuticals based on bilirubin extraction, comprising a tank body, an internal stirring mechanism, an exhaust pipe connected to one end of the top of the tank body, a plurality of evenly distributed exhaust holes at the top of the exhaust pipe, a shielding seat fixedly installed at the top of the exhaust pipe, a collection box fixedly fitted on the outside of the exhaust pipe, a liquid outlet pipe connected to one end of the bottom of the collection box, an antifoaming mechanism and a pushing mechanism internally arranged in the exhaust pipe, and an antifoaming agent spraying mechanism internally arranged in the collection box.

[0006] Preferably, the bottom of the tank is connected to a discharge pipe, and the top of the tank away from the exhaust pipe is connected to an inlet pipe.

[0007] Preferably, the stirring mechanism includes a stirring motor, which is fixedly installed on the top of the tank. The output shaft of the stirring motor passes through the tank and extends into the interior of the tank. A spline shaft is fixedly installed on the output shaft of the stirring motor. A stirring rod is fixedly installed on the bottom of the spline shaft. A spline sleeve is slidably fitted on the outside of the spline shaft. Two defoaming paddles and two sets of floats are fixedly installed on the outside of the spline sleeve. The two defoaming paddles and the two sets of floats are symmetrically arranged on the outside of the spline shaft. The bottom of the two defoaming paddles is serrated.

[0008] Preferably, the defoaming mechanism includes a drive motor, which is fixedly installed on the top of the shielding seat. The output shaft of the drive motor passes through the shielding seat and extends into the interior of the exhaust pipe. A transmission shaft is fixedly installed on the output shaft of the drive motor. Defoaming plates are fixedly installed on both sides of the bottom of the transmission shaft. Multiple evenly distributed defoaming spikes are fixedly installed on both sides of the two defoaming plates.

[0009] Preferably, the pushing mechanism includes a foam pushing ring seat, a foam pushing plate, a cylinder, and a transmission assembly. The foam pushing ring seat is disposed inside the shielding seat. Guide rods are slidably sleeved at both ends of the foam pushing ring seat. Both guide rods are fixedly installed inside the shielding seat. Springs are sleeved on the outside of both guide rods. The foam pushing plate is disposed inside the exhaust pipe and sleeved on the outside of the transmission shaft. Push rods are fixedly installed at both ends of the top of the foam pushing plate. A connecting plate is fixedly installed on the top of both push rods. The cylinder is fixedly installed on the top of the tank. The telescopic shaft end of the cylinder is fixedly connected to the connecting plate.

[0010] Preferably, the transmission assembly includes two push rods, two push rods, and two guide rods. The two push rods are fixedly installed on one side of the two push rods, and the two push rods are fixedly connected to the two push rods. The bottom of the two guide rods is fixedly connected to the collection box. An annular plate is slidably sleeved on the outside of the two guide rods. A spring is sleeved on the outside of the two guide rods. Multiple evenly distributed strip rods are fixedly installed on the bottom of the annular plate. Multiple evenly distributed protrusions are fixedly installed on the side of the bottom of the multiple strip rods near the shielding seat. Through holes are opened at both ends of the top of the shielding seat, and the two through holes cooperate with the two push rods respectively.

[0011] Preferably, the defoamer spraying mechanism includes an annular pipe, which is fixedly installed at the bottom of the outside of the collection box. One side of the annular pipe is connected to a delivery pipe, and the inner side of the annular pipe is connected to multiple evenly distributed flexible hoses. The ends of the multiple flexible hoses away from the annular pipe are all connected to fan-shaped nozzles, and the exterior of the multiple fan-shaped nozzles is provided with adjustment components.

[0012] Preferably, the adjustment assembly includes a fixed plate, a rotating shaft is rotatably mounted inside the fixed plate, one side of the rotating shaft is fixedly connected to a fan-shaped nozzle, a torsion spring is sleeved on the outside of the end of the rotating shaft away from the fan-shaped nozzle, the two ends of the torsion spring are fixedly connected to the rotating shaft and one side of the fixed plate respectively, a flip plate is fixedly mounted on the side of the rotating shaft away from the fan-shaped nozzle, and a limit rod is fixedly mounted on the end of the fixed plate near the rotating shaft, the bottom of the limit rod is in contact with the surface of the flip plate.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] 1. By installing a defoaming mechanism inside the exhaust pipe, when the amount of foam generated exceeds the processing capacity of the defoaming paddle and is sprayed out of the exhaust pipe, the two defoaming plates in the defoaming mechanism will puncture and eliminate the foam. In the process of extracting bilirubin from pig bile in biopharmaceutical manufacturing, this avoids the problem of bilirubin loss caused by foam sprayed out through the exhaust pipe carrying some bilirubin.

[0015] 2. Through the defoamer spraying mechanism, the tiny foams that are not eliminated by the defoamer are discharged through multiple vents. The defoamer spraying mechanism then sprays out heterocyclic compound defoamers (such as pyrrolidone or imidazole), which can break the tiny foams. The bilirubin and defoamer remaining in the foam are left inside the collection box and discharged through the outlet pipe. After the defoamer is removed from the bilirubin, it is added back into the tank for subsequent reactions, thus avoiding the loss of bilirubin.

[0016] 3. The adjustment and transmission components can be used to push the foam inside the exhaust pipe and between the shield and the exhaust pipe downwards. Combined with the defoamer spraying mechanism, the foam can be eliminated, preventing the foam inside the exhaust pipe and between the shield and the exhaust pipe from solidifying and causing blockages. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 This is a schematic diagram of the stirring mechanism of the present invention;

[0019] Figure 3 This is a schematic diagram of the defoaming paddle structure of the present invention;

[0020] Figure 4 This is a schematic diagram of the top structure of the exhaust pipe of the present invention;

[0021] Figure 5 This is a partial cross-sectional view of the present invention;

[0022] Figure 6 This is a schematic diagram of the defoaming mechanism of the present invention;

[0023] Figure 7 This is a schematic diagram of the defoamer spraying mechanism and the driving mechanism of the present invention;

[0024] Figure 8 This is a schematic diagram of the bar structure of the present invention;

[0025] Figure 9 This is a schematic diagram of the adjustment component structure of the present invention;

[0026] Figure 10 This is a schematic diagram of the internal structure of the collection box of the present invention;

[0027] Figure 11 This is a schematic diagram of the bottom structure of the foam-driven ring seat of the present invention.

[0028] The components represented by each number in the attached diagram are listed below: 1. Tank body; 2. Exhaust pipe; 3. Discharge pipe; 4. Inlet pipe; 5. Exhaust port; 6. Stirring motor; 7. Splined shaft; 8. Stirring rod; 9. Splined sleeve; 10. Defoaming paddle; 11. Float; 12. Baffle seat; 13. Collection box; 14. Liquid outlet pipe; 15. Drive motor; 16. Transmission shaft; 17. Defoaming plate; 18. Defoaming spike; 19. Foam pushing ring seat; 20. Guide rod one; 21. Foam pusher plate; 22. Push rod; 23. Connecting plate; 24. Cylinder; 25. Push rod one; 26. Push rod two; 27. Guide rod two; 28. Annular plate; 29. ​​Spring two; 30. Strip rod; 31. Protrusion; 32. Through hole; 33. Annular pipe; 34. Delivery pipe; 35. Hose; 36. Fan-shaped nozzle; 37. Fixing plate; 38. Rotating shaft; 39. Torsion spring; 40. Flipping plate; 41. Limiting rod; 42. Spring one. Detailed Implementation

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] This invention provides a technical solution: such as Figures 1-11The heating and cooling tank for manufacturing biopharmaceuticals based on bilirubin extraction shown includes a tank body 1. A stirring mechanism is installed inside the tank body 1. One end of the top of the tank body 1 is connected to an exhaust pipe 2. Multiple evenly distributed exhaust holes 5 are opened at the top of the exhaust pipe 2. A shielding seat 12 is fixedly installed on the top of the exhaust pipe 2. A collection box 13 is fixedly fitted on the outside of the exhaust pipe 2. One end of the bottom of the collection box 13 is connected to a liquid outlet pipe 14. A defoaming mechanism and a pushing mechanism are installed inside the exhaust pipe 2. A defoaming agent spraying mechanism is installed inside the collection box 13.

[0031] The bottom of the tank 1 is connected to the discharge pipe 3, and the top of the tank 1, away from the exhaust pipe 2, is connected to the inlet pipe 4.

[0032] The stirring mechanism includes a stirring motor 6, which is fixedly installed on the top of the tank 1. The output shaft of the stirring motor 6 passes through the tank 1 and extends into the interior of the tank 1. A splined shaft 7 is fixedly installed on the output shaft of the stirring motor 6. A stirring rod 8 is fixedly installed on the bottom of the splined shaft 7. A splined sleeve 9 is slidably fitted on the outside of the splined shaft 7. Two defoaming paddles 10 and two sets of floats 11 are fixedly installed on the outside of the splined sleeve 9. The two defoaming paddles 10 and the two sets of floats 11 are symmetrically arranged on the outside of the splined shaft 7. The bottom of the two defoaming paddles 10 is serrated.

[0033] The defoaming mechanism includes a drive motor 15, which is fixedly installed on the top of the shielding seat 12. The output shaft of the drive motor 15 passes through the shielding seat 12 and extends into the interior of the exhaust pipe 2. A transmission shaft 16 is fixedly installed on the output shaft of the drive motor 15. Defoaming plates 17 are fixedly installed on both sides of the bottom of the transmission shaft 16. Multiple evenly distributed defoaming spikes 18 are fixedly installed on both sides of the two defoaming plates 17.

[0034] The driving mechanism includes a foam pushing ring seat 19, a foam pushing plate 21, a cylinder 24, and a transmission assembly. The foam pushing ring seat 19 is located inside the shielding seat 12. Guide rods 20 are slidably sleeved at both ends inside the foam pushing ring seat 19. Both guide rods 20 are fixedly installed inside the shielding seat 12. Springs 42 are sleeved on the outside of both guide rods 20. The foam pushing plate 21 is located inside the exhaust pipe 2. The foam pushing plate 21 is sleeved on the outside of the transmission shaft 16. Push rods 22 are fixedly installed at both ends of the top of the foam pushing plate 21. A connecting plate 23 is fixedly installed on the top of both push rods 22. The cylinder 24 is fixedly installed on the top of the tank 1. The telescopic shaft end of the cylinder 24 is fixedly connected to the connecting plate 23.

[0035] The transmission assembly includes two push rods 25, two push rods 26, and two guide rods 27. The two push rods 25 are fixedly installed on one side of the two push rods 22, and the two push rods 26 are fixedly connected to the two push rods 25. The bottom of the two guide rods 27 is fixedly connected to the collection box 13. The outer sides of the two guide rods 27 are slidably fitted with an annular plate 28. The outer sides of the two guide rods 27 are fitted with springs 29. The bottom of the annular plate 28 is fixedly installed with multiple evenly distributed strip rods 30. The bottom of the multiple strip rods 30 near the side of the shielding seat 12 is fixedly installed with multiple evenly distributed protrusions 31. The top of the shielding seat 12 has through holes 32 at both ends, and the two through holes 32 cooperate with the two push rods 25 respectively.

[0036] The defoamer spraying mechanism includes an annular pipe 33, which is fixedly installed at the bottom of the outside of the collection box 13. A delivery pipe 34 is connected to one side of the annular pipe 33, and multiple evenly distributed hoses 35 are connected to the inside of the annular pipe 33. Each hose 35 is connected to a fan-shaped nozzle 36 at the end away from the annular pipe 33, and an adjustment component is provided on the outside of each fan-shaped nozzle 36.

[0037] The adjustment assembly includes a fixed plate 37, a rotating shaft 38 is rotatably mounted inside the fixed plate 37, one side of the rotating shaft 38 is fixedly connected to the fan-shaped nozzle 36, a torsion spring 39 is sleeved on the outside of the end of the rotating shaft 38 away from the fan-shaped nozzle 36, the two ends of the torsion spring 39 are fixedly connected to the rotating shaft 38 and one side of the fixed plate 37 respectively, a flip plate 40 is fixedly mounted on the side of the rotating shaft 38 away from the fan-shaped nozzle 36, a limit rod 41 is fixedly mounted on the end of the fixed plate 37 near the rotating shaft 38, and the bottom of the limit rod 41 is in contact with the surface of the flip plate 40.

[0038] Working principle: Fresh pig bile is filtered to remove impurities and then fed into tank 1 through feed pipe 4. The pig bile is heated by the heating system in tank 1, and a certain amount of NaOH solution is slowly added. Then, the stirring motor 6 is started, driving the spline shaft 7 and stirring rod 8 to rotate and stir the raw materials inside tank 1. The conjugated bilirubin in the pig bile is hydrolyzed into free bilirubin. After the hydrolysis reaction is completed, the heating system is turned off and the cooling system is switched. A certain amount of hydrochloric acid is added into tank 1 for acidification, and the water-soluble sodium bilirubin salt is converted into water-insoluble free bilirubin. During the extraction process, the temperature during the bilirubin extraction process is strictly controlled by the heating and cooling systems to avoid bilirubin degradation. In addition, tank 1 is a light-proof container, which will not cause bilirubin isomerization or bond breaking degradation.

[0039] During the acidification reaction, foam will be generated. At this time, due to the operation of the stirring motor 6 and the cooperation of the spline shaft 7 and spline sleeve 9, the two defoaming paddles 10 rotate synchronously. Under the action of the two sets of floats 11, the two defoaming paddles 10 are always in contact with the liquid surface inside the tank 1, and the serrated bottom of the two defoaming paddles 10 will perform defoaming work.

[0040] When the foam generation capacity inside the tank 1 exceeds the processing capacity of the two defoaming paddles 10, the foam will enter the exhaust pipe 2. At this time, the drive motor 15 is started, which drives the transmission shaft 16 and the two defoaming plates 17 to rotate. The multiple defoaming spikes 18 in the two defoaming plates 17 puncture the foam and eliminate it. The two defoaming plates 17 are mainly effective at puncturing larger foams. Some small foams may continue to rise inside the exhaust pipe 2 and enter the collection box 13 through multiple exhaust holes 5. At this time, defoaming agent is delivered into the conveying pipe 34. The defoaming agent flows into multiple hoses 35 through the annular pipe 33 and is then sprayed onto the foam flowing out through multiple exhaust holes 5 through multiple fan-shaped nozzles 36. The defoaming agent reduces the surface tension of the foam liquid film, causing the small foams to break. The bilirubin and defoaming agent remaining in the foam remain inside the collection box 13 and are discharged through the liquid outlet pipe 14. After the staff removes the defoaming agent from the bilirubin, it is added back into the tank 1 for subsequent reactions.

[0041] When the foam inside the tank 1 stops being generated, the cylinder 24 is activated, driving the connecting plate 23 and the two push rods 22 to move downwards, which in turn drives the foam push plate 21 to move downwards. The foam push plate 21 pushes the residual foam in the inner wall of the exhaust pipe 2 downwards and accumulates. At this time, due to the continuous rotation of the two defoaming plates 17, the residual foam in the inner wall of the exhaust pipe 2 can be eliminated, avoiding the problem of foam solidification and blockage inside the exhaust pipe 2 due to prolonged lack of cleaning. At the same time, during the downward movement of the two push rods 22, the two top rods 1 25 and the two top rods 26 move downwards synchronously. The bottom of the two top rods 26 first touches the annular plate 28. The annular plate 28 slides downwards along the two guide rods 27 under force and squeezes the two springs 29. As the annular plate 28 moves downwards, the multiple strip rods 30 and multiple protrusions 31 at its bottom move downwards synchronously. At this time, the adjustment components in the multiple fan-shaped nozzles 36 move synchronously. The movement process of one of the adjustment components and the fan-shaped nozzles 36 is as follows: as the multiple protrusions 31 at its top move downwards... Moving downwards, when the bottommost protrusion 31 touches the flip plate 40, the flip plate 40 is forced to move the rotating shaft 38 synchronously, and the torsion spring 39 deforms accordingly. As the rotating shaft 38 rotates, the opening of the fan-shaped nozzle 36 moves upwards. When the protrusion 31 is misaligned with the flip plate 40, under the action of the torsion spring 39 and the limiting rod 41, the flip plate 40 drives the fan-shaped nozzle 36 to reset. When the flip plate 40 touches the next protrusion 31, the fan-shaped nozzle 36 rotates again, and so on, achieving the oscillating effect of the fan-shaped nozzle 36; The movement of the multiple fan-shaped nozzles 36 and the adjustment components is the same as described above. At the same time, during this process, the two push rods 25 act on the foam pushing ring seat 19 through the two through holes 32. The foam pushing ring seat 19 is forced to move downward along the two guide rods 20 and squeezes the two springs 42. The foam pushing ring seat 19 pushes the foam on the outside of the shield seat 12 and the exhaust pipe 2 downward. With the help of the multiple swinging fan-shaped nozzles 36, the foam at the bottom of the foam pushing ring seat 19 can be eliminated to avoid residue.

[0042] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0043] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A heating and cooling tank for biopharmaceutical applications based on bilirubin extraction, comprising a tank body (1), characterized in that: The tank (1) is equipped with a stirring mechanism inside. One end of the top of the tank (1) is connected to an exhaust pipe (2). The top of the exhaust pipe (2) has multiple evenly distributed exhaust holes (5). A shielding seat (12) is fixedly installed on the top of the exhaust pipe (2). A collection box (13) is fixedly fitted on the outside of the exhaust pipe (2). One end of the bottom of the collection box (13) is connected to a liquid outlet pipe (14). The exhaust pipe (2) is equipped with a defoaming mechanism and a pushing mechanism inside. The collection box (13) is equipped with a defoaming agent spraying mechanism inside.

2. The heating and cooling tank for biopharmaceutical extraction based on bilirubin as described in claim 1, characterized in that: The bottom of the tank (1) is connected to a discharge pipe (3), and the top of the tank (1) away from the exhaust pipe (2) is connected to an inlet pipe (4).

3. The heating and cooling tank for biopharmaceutical extraction based on bilirubin as described in claim 1, characterized in that: The stirring mechanism includes a stirring motor (6), which is fixedly installed on the top of the tank (1). The output shaft of the stirring motor (6) passes through the tank (1) and extends into the interior of the tank (1). A spline shaft (7) is fixedly installed on the output shaft of the stirring motor (6). A stirring rod (8) is fixedly installed on the bottom of the spline shaft (7). A spline sleeve (9) is slidably fitted on the outside of the spline shaft (7). Two defoaming paddles (10) and two sets of floats (11) are fixedly installed on the outside of the spline sleeve (9). The two defoaming paddles (10) and the two sets of floats (11) are symmetrically arranged on the outside of the spline shaft (7). The bottoms of the two defoaming paddles (10) are serrated.

4. A heating and cooling tank for biopharmaceutical extraction based on bilirubin, as described in claim 1, characterized in that: The defoaming mechanism includes a drive motor (15), which is fixedly installed on the top of the shielding seat (12). The output shaft of the drive motor (15) passes through the shielding seat (12) and extends into the interior of the exhaust pipe (2). A transmission shaft (16) is fixedly installed on the output shaft of the drive motor (15). Defoaming plates (17) are fixedly installed on both sides of the bottom of the transmission shaft (16). Multiple evenly distributed defoaming spikes (18) are fixedly installed on both sides of the two defoaming plates (17).

5. A heating and cooling tank for biopharmaceutical extraction based on bilirubin, as described in claim 1, characterized in that: The pushing mechanism includes a foam pushing ring seat (19), a foam pushing plate (21), a cylinder (24), and a transmission assembly. The foam pushing ring seat (19) is located inside the shielding seat (12). Guide rods (20) are slidably sleeved at both ends inside the foam pushing ring seat (19). Both guide rods (20) are fixedly installed inside the shielding seat (12). Springs (42) are sleeved on the outside of both guide rods (20). The foam pushing plate (21) is located inside the exhaust pipe (2). The foam pushing plate (21) is sleeved on the outside of the transmission shaft (16). Push rods (22) are fixedly installed at both ends of the top of the foam pushing plate (21). A connecting plate (23) is fixedly installed on the top of both push rods (22). The cylinder (24) is fixedly installed on the top of the tank (1). The telescopic shaft end of the cylinder (24) is fixedly connected to the connecting plate (23).

6. A heating and cooling tank for biopharmaceutical extraction based on bilirubin, as described in claim 5, characterized in that: The transmission assembly includes two push rods (25), two push rods (26), and two guide rods (27). The two push rods (25) are fixedly installed on one side of the two push rods (22), and the two push rods (26) are fixedly connected to the two push rods (25). The bottom of the two guide rods (27) is fixedly connected to the collection box (13), and an annular plate (28) is slidably sleeved on the outside of the two guide rods (27). Both guide rods 2 (27) are fitted with springs 2 (29). The bottom of the annular plate (28) is fixedly installed with multiple evenly distributed strip rods (30). The bottom of the multiple strip rods (30) near the shielding seat (12) is fixedly installed with multiple evenly distributed protrusions (31). The top of the shielding seat (12) is provided with through holes (32) at both ends. The two through holes (32) are respectively engaged with the two top rods 1 (25).

7. A heating and cooling tank for biopharmaceutical extraction based on bilirubin, as described in claim 1, characterized in that: The defoamer spraying mechanism includes an annular pipe (33), which is fixedly installed at the bottom of the outside of the collection box (13). One side of the annular pipe (33) is connected to a delivery pipe (34), and the inside of the annular pipe (33) is connected to multiple evenly distributed hoses (35). The ends of the multiple hoses (35) away from the annular pipe (33) are all connected to fan-shaped nozzles (36), and the outside of the multiple fan-shaped nozzles (36) is provided with adjustment components.

8. A heating and cooling tank for biopharmaceutical extraction based on bilirubin, as described in claim 7, characterized in that: The adjustment assembly includes a fixed plate (37), a rotating shaft (38) is rotatably mounted inside the fixed plate (37), one side of the rotating shaft (38) is fixedly connected to a fan-shaped nozzle (36), a torsion spring (39) is sleeved on the outside of the end of the rotating shaft (38) away from the fan-shaped nozzle (36), the two ends of the torsion spring (39) are fixedly connected to the rotating shaft (38) and one side of the fixed plate (37) respectively, a flip plate (40) is fixedly mounted on the side of the rotating shaft (38) away from the fan-shaped nozzle (36), a limit rod (41) is fixedly mounted on the end of the fixed plate (37) near the rotating shaft (38), and the bottom of the limit rod (41) is in contact with the surface of the flip plate (40).

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